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TDMS Study 05201-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 10/07/97

EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 14:59:08
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000
                 

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Kidney
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 10/07/97     
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 14:59:08     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000  



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 FURFURYL ALCOHOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Kidney, Renal Tubule (Step Section)    Adenoma
                                       Carcinoma and Adenoma
                                       Hyperplasia
                                       Hyperplasia and Adenoma
                                       Hyperplasia, Carcinoma or Adenoma
Kidney, Renal Tubule (Step and Original Sections)
                                       Adenoma
                                       Carcinoma and Adenoma
                                       Hyperplasia
                                       Hyperplasia and Adenoma
                                       Hyperplasia, Carcinoma or Adenoma
Kidney: Renal Tubule                   Hyperplasia
                                       Hyperplasia and Adenoma
                                       Hyperplasia, Carcinoma or Adenoma
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Kidney, Renal Tubule (Step Section)    Hyperplasia
                                       Hyperplasia and Adenoma
                                       Hyperplasia, Carcinoma or Adenoma
Kidney, Renal Tubule (Step and Original Sections)
                                       Hyperplasia
                                       Hyperplasia and Adenoma
                                       Hyperplasia, Carcinoma or Adenoma
Kidney: Renal Tubule                   Adenoma
                                       Hyperplasia
                                       Hyperplasia and Adenoma
                                       Hyperplasia, Carcinoma or Adenoma
===============================================================
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     3.1%         3.1%         3.0%         13.9%       |0.0%         0.0%         5.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    2/22 (9%)    0/16 (0%)    |
|FIRST INCIDENCE    |     715          735 (T)      708          609         |---          ---          735 (T)      707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.685      P=0.734N     P=0.006 **  |P=0.300      (e)          P=0.201      P=0.440      |
|POLY 3             |     P=0.041 *    P=0.758      P=0.756N     P=0.137     |P=0.379      (e)          P=0.234      P=0.485      |
|POLY 1.5           |     P=0.049 *    P=0.761      P=0.756N     P=0.161     |P=0.399      (e)          P=0.236      P=0.493      |
|POLY 6             |     P=0.028 *    P=0.747      P=0.758N     P=0.092     |P=0.352      (e)          P=0.228      P=0.474      |
|LOGISTIC REGRESSION|     P=0.008 **   P=0.714      P=0.756N     P=0.074     |P=0.344      (e)          P=0.201      P=0.475      |
|COCH-ARM / FISHERS |     P=0.057      P=0.753N     P=0.753N     P=0.181     |P=0.422      (e)          P=0.242      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Carcinoma and Adenoma                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    1/49 (2%)    2/49 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     3.1%         3.1%         3.0%         13.9%       |0.0%         2.4%         5.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    2/22 (9%)    0/16 (0%)    |
|FIRST INCIDENCE    |     715          735 (T)      708          609         |---          677          735 (T)      707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.685      P=0.734N     P=0.006 **  |P=0.447      P=0.523      P=0.201      P=0.440      |
|POLY 3             |     P=0.041 *    P=0.758      P=0.756N     P=0.137     |P=0.524      P=0.506      P=0.234      P=0.485      |
|POLY 1.5           |     P=0.049 *    P=0.761      P=0.756N     P=0.161     |P=0.544      P=0.503      P=0.236      P=0.493      |
|POLY 6             |     P=0.028 *    P=0.747      P=0.758N     P=0.092     |P=0.496      P=0.511      P=0.228      P=0.474      |
|LOGISTIC REGRESSION|     P=0.008 **   P=0.714      P=0.756N     P=0.074     |P=0.511      P=0.496      P=0.201      P=0.475      |
|COCH-ARM / FISHERS |     P=0.057      P=0.753N     P=0.753N     P=0.181     |P=0.566      P=0.495      P=0.242      P=0.500      |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   7/50 (14%)   23/50 (46%) |2/50 (4%)    1/49 (2%)    3/49 (6%)    9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     20.5%        15.5%        20.7%        63.3%       |4.9%         2.4%         7.5%         23.4%        |
|TERMINAL (d)       |     1/8 (13%)    2/5 (40%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    2/22 (9%)    2/16 (13%)   |
|FIRST INCIDENCE    |     581          637          666          526         |599          735 (T)      628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.558N     P=0.552N     P<0.001 **  |P<0.001 **   P=0.500N     P=0.453      P=0.012 *    |
|POLY 3             |     P<0.001 **   P=0.415N     P=0.614      P<0.001 **  |P<0.001 **   P=0.495N     P=0.494      P=0.018 *    |
|POLY 1.5           |     P<0.001 **   P=0.389N     P=0.611N     P<0.001 **  |P<0.001 **   P=0.498N     P=0.498      P=0.021 *    |
|POLY 6             |     P<0.001 **   P=0.481N     P=0.587      P<0.001 **  |P<0.001 **   P=0.491N     P=0.483      P=0.015 *    |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.436N     P=0.598N     P<0.001 **  |P<0.001 **   P=0.499N     P=0.496      P=0.020 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.380N     P=0.613N     P<0.001 **  |P<0.001 **   P=0.508N     P=0.490      P=0.026 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Hyperplasia and Adenoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   7/50 (14%)   24/50 (48%) |2/50 (4%)    1/49 (2%)    4/49 (8%)    10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     20.5%        15.5%        20.7%        65.2%       |4.9%         2.4%         10.0%        25.9%        |
|TERMINAL (d)       |     1/8 (13%)    2/5 (40%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    3/22 (14%)   2/16 (13%)   |
|FIRST INCIDENCE    |     581          637          666          526         |599          735 (T)      628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.558N     P=0.552N     P<0.001 **  |P<0.001 **   P=0.500N     P=0.287      P=0.006 **   |
|POLY 3             |     P<0.001 **   P=0.415N     P=0.614      P<0.001 **  |P<0.001 **   P=0.495N     P=0.330      P=0.009 **   |
|POLY 1.5           |     P<0.001 **   P=0.389N     P=0.611N     P<0.001 **  |P<0.001 **   P=0.498N     P=0.335      P=0.011 *    |
|POLY 6             |     P<0.001 **   P=0.481N     P=0.587      P<0.001 **  |P<0.001 **   P=0.491N     P=0.318      P=0.007 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.436N     P=0.598N     P<0.001 **  |P<0.001 **   P=0.499N     P=0.331      P=0.011 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.380N     P=0.613N     P<0.001 **  |P<0.001 **   P=0.508N     P=0.329      P=0.014 *    |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Hyperplasia, Carcinoma or Adenoma                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   7/50 (14%)   24/50 (48%) |2/50 (4%)    2/49 (4%)    4/49 (8%)    10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     20.5%        15.5%        20.7%        65.2%       |4.9%         4.8%         10.0%        25.9%        |
|TERMINAL (d)       |     1/8 (13%)    2/5 (40%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    3/22 (14%)   2/16 (13%)   |
|FIRST INCIDENCE    |     581          637          666          526         |599          677          628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.558N     P=0.552N     P<0.001 **  |P<0.001 **   P=0.682N     P=0.287      P=0.006 **   |
|POLY 3             |     P<0.001 **   P=0.415N     P=0.614      P<0.001 **  |P<0.001 **   P=0.687N     P=0.330      P=0.009 **   |
|POLY 1.5           |     P<0.001 **   P=0.389N     P=0.611N     P<0.001 **  |P<0.001 **   P=0.691N     P=0.335      P=0.011 *    |
|POLY 6             |     P<0.001 **   P=0.481N     P=0.587      P<0.001 **  |P<0.001 **   P=0.682N     P=0.318      P=0.007 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.436N     P=0.598N     P<0.001 **  |P<0.001 **   P=0.695      P=0.331      P=0.011 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.380N     P=0.613N     P<0.001 **  |P<0.001 **   P=0.684      P=0.329      P=0.014 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.3%         8.9%         13.9%       |0.0%         0.0%         5.0%         5.3%         |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    2/22 (9%)    0/16 (0%)    |
|FIRST INCIDENCE    |     681          726          700          609         |---          ---          735 (T)      686          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.588      P=0.549      P=0.014 *   |P=0.081      (e)          P=0.201      P=0.190      |
|POLY 3             |     P=0.186      P=0.687      P=0.514      P=0.273     |P=0.130      (e)          P=0.234      P=0.221      |
|POLY 1.5           |     P=0.218      P=0.694      P=0.511      P=0.311     |P=0.141      (e)          P=0.236      P=0.229      |
|POLY 6             |     P=0.127      P=0.667      P=0.514      P=0.195     |P=0.116      (e)          P=0.228      P=0.211      |
|LOGISTIC REGRESSION|     P=0.033 *    P=0.630      P=0.515      P=0.150     |P=0.110      (e)          P=0.201      P=0.217      |
|COCH-ARM / FISHERS |     P=0.244      P=0.691N     P=0.500      P=0.339     |P=0.155      (e)          P=0.242      P=0.247      |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Carcinoma and Adenoma                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |0/50 (0%)    1/49 (2%)    2/49 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.3%         8.9%         13.9%       |0.0%         2.4%         5.0%         5.3%         |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    2/22 (9%)    0/16 (0%)    |
|FIRST INCIDENCE    |     681          726          700          609         |---          677          735 (T)      686          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.588      P=0.549      P=0.014 *   |P=0.168      P=0.523      P=0.201      P=0.190      |
|POLY 3             |     P=0.186      P=0.687      P=0.514      P=0.273     |P=0.238      P=0.506      P=0.234      P=0.221      |
|POLY 1.5           |     P=0.218      P=0.694      P=0.511      P=0.311     |P=0.253      P=0.503      P=0.236      P=0.229      |
|POLY 6             |     P=0.127      P=0.667      P=0.514      P=0.195     |P=0.217      P=0.511      P=0.228      P=0.211      |
|LOGISTIC REGRESSION|     P=0.033 *    P=0.630      P=0.515      P=0.150     |P=0.221      P=0.496      P=0.201      P=0.217      |
|COCH-ARM / FISHERS |     P=0.244      P=0.691N     P=0.500      P=0.339     |P=0.271      P=0.495      P=0.242      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  7/50 (14%)   7/50 (14%)   25/50 (50%) |2/50 (4%)    1/49 (2%)    3/49 (6%)    11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     29.2%        21.4%        20.7%        67.0%       |4.9%         2.4%         7.5%         28.4%        |
|TERMINAL (d)       |     2/8 (25%)    2/5 (40%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    2/22 (9%)    3/16 (19%)   |
|FIRST INCIDENCE    |     581          609          666          526         |599          735 (T)      628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.504N     P=0.245N     P<0.001 **  |P<0.001 **   P=0.500N     P=0.453      P=0.003 **   |
|POLY 3             |     P<0.001 **   P=0.320N     P=0.293N     P<0.001 **  |P<0.001 **   P=0.495N     P=0.494      P=0.004 **   |
|POLY 1.5           |     P<0.001 **   P=0.299N     P=0.286N     P<0.001 **  |P<0.001 **   P=0.498N     P=0.498      P=0.005 **   |
|POLY 6             |     P<0.001 **   P=0.380N     P=0.322N     P<0.001 **  |P<0.001 **   P=0.491N     P=0.483      P=0.003 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.363N     P=0.264N     P<0.001 **  |P<0.001 **   P=0.499N     P=0.496      P=0.006 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.298N     P=0.298N     P=0.002 **  |P<0.001 **   P=0.508N     P=0.490      P=0.007 **   |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Hyperplasia and Adenoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  7/50 (14%)   9/50 (18%)   25/50 (50%) |2/50 (4%)    1/49 (2%)    4/49 (8%)    12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     31.9%        21.4%        26.4%        67.0%       |4.9%         2.4%         10.0%        30.9%        |
|TERMINAL (d)       |     2/8 (25%)    2/5 (40%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    3/22 (14%)   3/16 (19%)   |
|FIRST INCIDENCE    |     581          609          666          526         |599          735 (T)      628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.417N     P=0.333N     P<0.001 **  |P<0.001 **   P=0.500N     P=0.287      P=0.002 **   |
|POLY 3             |     P<0.001 **   P=0.235N     P=0.404N     P<0.001 **  |P<0.001 **   P=0.495N     P=0.330      P=0.002 **   |
|POLY 1.5           |     P<0.001 **   P=0.217N     P=0.392N     P=0.002 **  |P<0.001 **   P=0.498N     P=0.335      P=0.003 **   |
|POLY 6             |     P<0.001 **   P=0.290N     P=0.446N     P<0.001 **  |P<0.001 **   P=0.491N     P=0.318      P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.269N     P=0.368N     P<0.001 **  |P<0.001 **   P=0.499N     P=0.331      P=0.003 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.218N     P=0.402N     P=0.003 **  |P<0.001 **   P=0.508N     P=0.329      P=0.004 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Hyperplasia, Carcinoma or Adenoma                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  7/50 (14%)   9/50 (18%)   25/50 (50%) |2/50 (4%)    2/49 (4%)    4/49 (8%)    12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     31.9%        21.4%        26.4%        67.0%       |4.9%         4.8%         10.0%        30.9%        |
|TERMINAL (d)       |     2/8 (25%)    2/5 (40%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    3/22 (14%)   3/16 (19%)   |
|FIRST INCIDENCE    |     581          609          666          526         |599          677          628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.417N     P=0.333N     P<0.001 **  |P<0.001 **   P=0.682N     P=0.287      P=0.002 **   |
|POLY 3             |     P<0.001 **   P=0.235N     P=0.404N     P<0.001 **  |P<0.001 **   P=0.687N     P=0.330      P=0.002 **   |
|POLY 1.5           |     P<0.001 **   P=0.217N     P=0.392N     P=0.002 **  |P<0.001 **   P=0.691N     P=0.335      P=0.003 **   |
|POLY 6             |     P<0.001 **   P=0.290N     P=0.446N     P<0.001 **  |P<0.001 **   P=0.682N     P=0.318      P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.269N     P=0.368N     P<0.001 **  |P<0.001 **   P=0.695      P=0.331      P=0.003 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.218N     P=0.402N     P=0.003 **  |P<0.001 **   P=0.684      P=0.329      P=0.004 **   |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     3.1%         3.1%         6.0%         0.0%        |0.0%         0.0%         0.0%         5.3%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     681          726          700          ---         |---          ---          ---          686          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.852      P=0.708      P=0.536      P=0.872N    |P=0.026 *    (e)          (e)          P=0.190      |
|POLY 3             |     P=0.373N     P=0.757      P=0.510      P=0.535N    |P=0.037 *    (e)          (e)          P=0.221      |
|POLY 1.5           |     P=0.341N     P=0.761      P=0.509      P=0.514N    |P=0.039 *    (e)          (e)          P=0.229      |
|POLY 6             |     P=0.448N     P=0.746      P=0.510      P=0.584N    |P=0.035 *    (e)          (e)          P=0.211      |
|LOGISTIC REGRESSION|     P=0.634N     P=0.732      P=0.510      P=0.697N    |P=0.035 *    (e)          (e)          P=0.217      |
|COCH-ARM / FISHERS |     P=0.317N     P=0.753N     P=0.500      P=0.500N    |P=0.043 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     3.1%         3.1%         6.0%         0.0%        |0.0%         2.4%         0.0%         5.3%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     681          726          700          ---         |---          677          ---          686          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.852      P=0.708      P=0.536      P=0.872N    |P=0.109      P=0.523      (e)          P=0.190      |
|POLY 3             |     P=0.373N     P=0.757      P=0.510      P=0.535N    |P=0.142      P=0.506      (e)          P=0.221      |
|POLY 1.5           |     P=0.341N     P=0.761      P=0.509      P=0.514N    |P=0.148      P=0.503      (e)          P=0.229      |
|POLY 6             |     P=0.448N     P=0.746      P=0.510      P=0.584N    |P=0.134      P=0.511      (e)          P=0.211      |
|LOGISTIC REGRESSION|     P=0.634N     P=0.732      P=0.510      P=0.697N    |P=0.139      P=0.496      (e)          P=0.217      |
|COCH-ARM / FISHERS |     P=0.317N     P=0.753N     P=0.500      P=0.500N    |P=0.155      P=0.495      (e)          P=0.247      |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   2/50 (4%)    6/50 (12%)  |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     15.1%        15.3%        6.0%         20.6%       |0.0%         0.0%         0.0%         5.3%         |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     617          609          688          580         |---          ---          ---          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.486      P=0.188N     P<0.001 **  |P=0.022 *    (e)          (e)          P=0.178      |
|POLY 3             |     P=0.290      P=0.628      P=0.203N     P=0.407     |P=0.037 *    (e)          (e)          P=0.221      |
|POLY 1.5           |     P=0.334      P=0.630N     P=0.206N     P=0.464     |P=0.039 *    (e)          (e)          P=0.229      |
|POLY 6             |     P=0.209      P=0.607      P=0.204N     P=0.279     |P=0.034 *    (e)          (e)          P=0.210      |
|LOGISTIC REGRESSION|     P=0.082      P=0.568      P=0.199N     P=0.106     |P=0.035 *    (e)          (e)          P=0.217      |
|COCH-ARM / FISHERS |     P=0.371      P=0.630N     P=0.218N     P=0.500     |P=0.043 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia and Adenoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   4/50 (8%)    6/50 (12%)  |0/50 (0%)    0/49 (0%)    0/49 (0%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     18.0%        15.3%        11.8%        20.6%       |0.0%         0.0%         0.0%         10.6%        |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     617          609          688          580         |---          ---          ---          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.595      P=0.317N     P=0.002 **  |P<0.001 **   (e)          (e)          P=0.038 *    |
|POLY 3             |     P=0.390      P=0.513N     P=0.353N     P=0.527     |P<0.001 **   (e)          (e)          P=0.052      |
|POLY 1.5           |     P=0.445      P=0.499N     P=0.355N     P=0.585     |P<0.001 **   (e)          (e)          P=0.056      |
|POLY 6             |     P=0.281      P=0.550N     P=0.357N     P=0.383     |P<0.001 **   (e)          (e)          P=0.047 *    |
|LOGISTIC REGRESSION|     P=0.114      P=0.572N     P=0.347N     P=0.168     |P<0.001 **   (e)          (e)          P=0.051      |
|COCH-ARM / FISHERS |     P=0.489      P=0.500N     P=0.370N     P=0.620N    |P=0.002 **   (e)          (e)          P=0.059      |
|=================================================================================================================================|
       Date:  10/07/97                           EXPERIMENT: 05201 TEST: 05                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia, Carcinoma or Adenoma                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   4/50 (8%)    6/50 (12%)  |0/50 (0%)    1/49 (2%)    0/49 (0%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     18.0%        15.3%        11.8%        20.6%       |0.0%         2.4%         0.0%         10.6%        |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     617          609          688          580         |---          677          ---          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.595      P=0.317N     P=0.002 **  |P=0.004 **   P=0.523      (e)          P=0.038 *    |
|POLY 3             |     P=0.390      P=0.513N     P=0.353N     P=0.527     |P=0.008 **   P=0.506      (e)          P=0.052      |
|POLY 1.5           |     P=0.445      P=0.499N     P=0.355N     P=0.585     |P=0.009 **   P=0.503      (e)          P=0.056      |
|POLY 6             |     P=0.281      P=0.550N     P=0.357N     P=0.383     |P=0.007 **   P=0.511      (e)          P=0.047 *    |
|LOGISTIC REGRESSION|     P=0.114      P=0.572N     P=0.347N     P=0.168     |P=0.007 **   P=0.496      (e)          P=0.051      |
|COCH-ARM / FISHERS |     P=0.489      P=0.500N     P=0.370N     P=0.620N    |P=0.011 *    P=0.495      (e)          P=0.059      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).