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https://ntp.niehs.nih.gov/go/12029

TDMS Study 05201-05 Pathology Tables

NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25

                                                    2 YEAR CHRONIC FINAL #2




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0|             
                                           | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X        X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                         X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X           X              X  X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3        2         |             
      Basophilic Focus                     | X     X     X        X  X  X  X     X  X  X  X  X  X  X  X     X  X  X   |             
      Clear Cell Focus                     |    X                                   X                                 |             
      Cyst                                 |             4                                                            |             
      Degeneration, Fatty                  | 1     1  3     2                             3        1           2     3|             
      Eosinophilic Focus                   |                                     X                          X         |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Mixed Cell Focus                     |    X                    X     X                                          |             
      Necrosis                             |                1                                                         |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |          2  1                                                           2|             
      Centrilobular, Necrosis              |       1                          1                                      1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                 +                 +     +  +              +         |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |    2                 2                 2     2  2              2         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                          +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1     4  2              1                             2        1        2|             
      Basophilic Focus                     |             X                    X                                       |             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         1                                                |             
      Necrosis                             |          3                                   3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         1                                                |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0|             
                                           | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1        1  1  2  1     2  2  2  1  1     1        2     2   |             
      Atrium, Thrombosis                   |          1                       3                                      1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |             1        2        2     2  2  2        1  2  3     2         |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                            2                                             |             
      Vacuolization Cytoplasmic            |             2     2                                   3           2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  1  2                                3                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                2                          2              3              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  1  1  2  1  2  2  2     2  1  2  1  2  2  2  1  1  1     2  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                         3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     4                                3  3|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3           2                                         1                  |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0|             
                                           | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                         2|             
      Hyperplasia, Focal                   |                                                                3         |             
      Inflammation, Granulomatous          |                                     3                                    |             
      Metaplasia, Lipocyte                 |                                     3                                    |             
      Necrosis                             |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |          2              3                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       1     3                 3              2                 2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                         2|             
      Inflammation, Granulomatous          |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1                                1                          1   |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                        1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |          4                       1                       1              4|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                2  2  1  1     1  2  2  1  1  1  1  2  1  2  1  1  1  1  1|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                   1           1     1        1     1     1  1  1  1     1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0|             
                                           | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                         2|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Nephropathy                          | 2  2  1  2  2  1  2  2  2  2  3  2  2  2  2  1  2  2  2        3  2  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                          X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                 X                        |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      3  2.3|
      Basophilic Focus                     | X  X        X  X  X        X              X  X        X  X        X     X|     30     |
      Clear Cell Focus                     | X                          X              X                              |      5     |
      Cyst                                 |                                                                          |      1  4.0|
      Degeneration, Fatty                  |          3           2        3  1                 1                     |     13  2.0|
      Eosinophilic Focus                   | X                                                                        |      3     |
      Hepatodiaphragmatic Nodule           |                X        X                                X               |      4     |
      Infiltration Cellular, Histiocyte    |                      2                                                   |      1  2.0|
      Mixed Cell Focus                     |    X        X                       X  X  X     X                        |      9     |
      Necrosis                             |                                                                          |      1  1.0|
      Thrombosis                           |                                                 2                        |      1  2.0|
      Bile Duct, Hyperplasia               |                                                 2              1  1      |      6  1.5|
      Centrilobular, Necrosis              |                      1                          1              1         |      6  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +  +                          +     +        +  +  +  +      |  15        |
      Fat, Hemorrhage                      |                                                                2         |      1  2.0|
      Fat, Necrosis                        |             3  2                          2     2        2  3     2      |     13  2.2|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                1                       1                          3      |     10  1.8|
      Basophilic Focus                     |             X                       X                                    |      4     |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                      3        3     3                                    |      5  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                     1                                    |      2  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
      Pulp, Necrosis                       |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1           1     1        1  1     1  2  2  1  1  1        1        1  2|     29  1.3|
      Atrium, Thrombosis                   |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   2                                                      |      1  2.0|
      Hyperplasia                          | 1           2              2     2  1        1              2  2        2|     19  1.8|
      Hypertrophy                          |                1                                            2            |      2  1.5|
      Necrosis                             |          3                       3                 2                     |      4  2.5|
      Vacuolization Cytoplasmic            |                               2                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2        1     1        1  3                       2           2  2   |     12  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |          1     3                                         1        4      |      8  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2           2  1     1     1  1  1  2     2  1  2  2     1  3     1  1  1|     40  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|  44        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             |                                                                4        4|      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                    +                                   +      |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M  +  M  +  +  +  +  M  +|  37        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                          2     3         |      5  2.2|
      Hematopoietic Cell Proliferation     |                                                    3                     |      2  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Metaplasia, Lipocyte                 |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                              3                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                       3  4        3      |      8  2.6|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epiglottis, Metaplasia, Squamous     |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                      3                                                   |      2  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       2                                                                  |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1  2     2                             1  1  3                           |      9  1.4|
      Perivascular, Infiltration Cellular, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    1                 2                 2           4                     |      4  2.3|
      Thrombosis                           |          4           3                          2                        |      7  2.7|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  1  2  1  2  1  1  1     1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     43  1.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |       1  1  1  1  1  1        1  1        1           1     1  1  1      |     23  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
      Cataract                             |                                                                   4      |      1  4.0|
      Retina, Atrophy                      |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |          2                                                               |      2  2.0|
      Infiltration Cellular, Histiocyte    |                      2                                                   |      1  2.0|
      Nephropathy                          | 2  2  2  2  2  1  2  1     1  2  2  3  3  2  2  2  1  2  2  2  1  2  2  2|     47  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X     X     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                       X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     | X     X     X  X           X  X  X  X  X     X     X        X  X  X     X|             
      Clear Cell Focus                     |                            X     X                 X              X      |             
      Degeneration, Fatty                  |                2                          2     3        2               |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Hepatodiaphragmatic Nodule           |             X                    X  X        X                       X  X|             
      Mixed Cell Focus                     | X              X              X  X     X           X                     |             
      Necrosis                             |                                                                          |             
      Regeneration                         |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       2                                                                  |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Necrosis              |                               1                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +              +                                    |             
      Fat, Necrosis                        |                                     1                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Hyperplasia, Squamous    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2           2        1  2  2                    2     2           2  2|             
      Basophilic Focus                     |                               X                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                          3               |             
      Necrosis                             |                3        1                 3     3                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1              3                                                         |             
      Necrosis                             |                         2                 3                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                   +                    +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
      Aorta, Mineralization                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  2     2           2     2           1     1     1  1     1  1  1|             
      Artery, Mineralization               |                2                                                         |             
      Atrium, Thrombosis                   |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |             1                          1           2     2           2   |             
      Hypertrophy                          |       2                                               3                  |             
      Necrosis                             |                3                                                         |             
      Vacuolization Cytoplasmic            |                         2                                               2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1     1        2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                  3  2                             3     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1     2     1     1     1  1  1  2  1  1  2  3  2  2  3  2  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
      Hyperplasia                          |                                     1     3                              |             
      Inflammation, Chronic Active         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3                 3         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +                       +      |             
      Renal, Hemorrhage                    |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  M  M  +  +  +  M  +  M  M  +  +  M  +  +  M  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                          3               |             
      Hematopoietic Cell Proliferation     |                         4     4                                          |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |             3                                                  1         |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2                                            3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                1                                                         |             
      Hyperostosis                         |                3                    1  1  1        4     4              3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                3                                                         |             
      Alveolar Epithelium, Hyperplasia     |    2  1     1  1  1              3  1  2                       1        1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                         4                                                |             
      Lateral Wall, Hyperplasia            | 1  1     1  1  2     2  1  1  2  1  1  1  1     2     1  1  1  1  1     1|             
      Lateral Wall, Metaplasia, Squamous   |                                                             1            |             
      Olfactory Epithelium, Atrophy        |       1        2                                   1                     |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  2  1  1  3  2  1  2  2  2  2  2  2  1  1  1  1  1  2  1  2  1  1  2|             
      Olfactory Epithelium, Metaplasia     |       1                                            1                     |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1     1     1  1  1  1  1  1  2  1  1  1  1  1  1  1     2  1  1  1     1|             
      Respiratory Epithelium, Hyperplasia  | 2  1           2     1  1                             1     1  2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                2                                                         |             
      Nephropathy                          | 2  2  1     3  4  1     1  3  1  1  2  2  1  2  2  1  2  2  1  2  2  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3|            |
                                           | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  47        |
      Parasite Metazoan                    |                         X                                               X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                       X           X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                 1                        |      2  1.0|
      Basophilic Focus                     | X     X  X  X  X  X     X  X        X  X  X  X  X  X  X     X            |     31     |
      Clear Cell Focus                     |       X                          X                                       |      6     |
      Degeneration, Fatty                  |                      3              1        2           3           3   |      9  2.3|
      Eosinophilic Focus                   |                                                       X     X            |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                           X                              |      7     |
      Mixed Cell Focus                     |    X     X  X                          X        X     X     X            |     13     |
      Necrosis                             |                                           3                              |      1  3.0|
      Regeneration                         |                            3                                             |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                            3     1                    1  2        2  3  1|      7  1.9|
      Centrilobular, Necrosis              | 1              1           2                 1                       1   |      6  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                 +     +        +  +  +                        |   8        |
      Fat, Necrosis                        |          2                 3     2        1  2  2                        |      7  1.9|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                   +                                                      |   1        |
      Pharyngeal, Hyperplasia, Squamous    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             1                                         2                  |     11  1.8|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Necrosis                             |                                                          3     1         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3|            |
                                           | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                  +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1        2  1              1  2     1           1     1  1        2|     24  1.3|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                      3                                               2   |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                   3      |      1  3.0|
      Hyperplasia                          | 2  1        2     2  2  2  2     2  2  2     2  1  2  2  1  2  3         |     22  1.8|
      Hypertrophy                          |                   2                                                     2|      4  2.3|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                     2                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                          2                 3                 2   |      7  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +|  43        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           | 2                    2  2  2     3                    3                  |     10  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2  1  2  1     3  1  1  1  1  1  1  1  1     1  1  1  2     1  1     1  2|     41  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M|  45        |
      Hyperplasia                          |                                                    2  2  2               |      5  2.0|
      Inflammation, Chronic Active         |          3                 3                                             |      3  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       1                       1                             3            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3|            |
                                           | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                              +                    +  +   |   5        |
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  M  M  +  +  +  +  M  +  +  +  +  +  M  M  M  +  M  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  M  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                      2                                               3   |      3  2.7|
      Hematopoietic Cell Proliferation     |                4                          3                              |      4  3.8|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|
      Hyperostosis                         |             2        3     1           2  3        2  3                  |     14  2.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |             2              2     1  3  1        1                        |     16  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                      2   |      1  2.0|
      Thrombosis                           |                      3                                               2   |      3  3.0|
      Lateral Wall, Hyperplasia            | 2  1     1        1  2  2  2  1  2  1  2  1  1        1  1  1  1  2  1   |     39  1.3|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3|            |
                                           | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lateral Wall, Metaplasia, Squamous   |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |    1  1                                2                                 |      6  1.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 3  2  2  2  2  2  2  3  3  2  1  1  1  1  1  1  1  2  2  1  2  1  1  1  2|     50  1.6|
      Olfactory Epithelium, Metaplasia     |    1  1                                2                                 |      5  1.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  1     1  2  1  2  1  3  1  1              1  1  2  2     1     1  1  1|     39  1.2|
      Respiratory Epithelium, Hyperplasia  | 1        1           2  1  2     2  2  2              1     1            |     18  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                               1                                          |      1  1.0|
      Infarct                              |             1                                                            |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  2  2     2  1  2  1  3     2  2  2     2  2  2  2  2  3  2  2  2  2|     45  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  17                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3|             
                                           | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |          X                    X  X                       X              X|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Basophilic Focus                     | X  X  X  X  X        X  X     X  X        X  X        X        X     X  X|             
      Clear Cell Focus                     |       X     X                                X                           |             
      Degeneration, Cystic                 |             2                                                            |             
      Degeneration, Fatty                  |                         1  3        3     2        2  3                  |             
      Eosinophilic Focus                   |                                           X                              |             
      Hepatodiaphragmatic Nodule           |          X                    X                    X              X      |             
      Inflammation, Granulomatous          |                   2                                                      |             
      Mixed Cell Focus                     |                                                 X                        |             
      Bile Duct, Hyperplasia               |                                        2  2           2     2            |             
      Centrilobular, Necrosis              |                1           1           1           1  2     1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +  +                 +                    +  +                  |             
      Fat, Necrosis                        |       2  2  2                 2                    2  2                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Hyperplasia, Squamous    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     2           1     1  2        2  1                              |             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                             2            |             
      Inflammation, Acute                  |                         2                                                |             
      Necrosis                             |                            2              3           3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1                                                   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     1     1        1  1     2                          1        1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3|             
                                           | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 2  1  1  2     1        2        2              2        2  2  2         |             
      Hypertrophy                          |                                                                2     3  2|             
      Vacuolization Cytoplasmic            |          2                 2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |                2                          2                    1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                    2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |       3                                                                  |             
      Pars Distalis, Hyperplasia           |       3                       4  2     2           2        2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      C-Cell, Hyperplasia                  | 1  1     2  1  1     1  1  1  2  1  1  1     2     2  1  1     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                4                                   2        2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                    +     +  +     +           +        +|             
      Renal, Hemorrhage                    |                                     2                                    |             
      Renal, Pigmentation                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                            X                 X                           |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3|             
                                           | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                2                                      1                  |             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                            2           3        2  4        2     2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                     2                          2         |             
      Alveolar Epithelium, Hyperplasia     | 1     1                          1  1     4                 1  1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                            2           1           2  3     2            |             
      Glands, Hyperplasia                  |    1  1     1  1     1  1        1     1        1  1  1  1     1  1  1   |             
      Lateral Wall, Hyperplasia            | 2  2  2  2  2  3     2  2  2  2  2  2  2  1  2  2  3  3  2  2  2  2  2  2|             
      Olfactory Epithelium, Atrophy        |    2  2  2  2  2     2  1  2  2  2  1  2  2  2  1  2  2  1  2  2  2  2  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  3  3  3  3  3     2  2  2     2  3  3  2  3  3  3  2  3  3  3  2  2  2|             
      Olfactory Epithelium, Fibrosis       |    2  2  1  1                 2                          1  1     2      |             
      Olfactory Epithelium, Hyperplasia    |    2  2  1  1  1     1        2  1           1  1  2  1  1  1  1  2      |             
      Olfactory Epithelium, Metaplasia     |    2  2  2  1        2  1     2  2  1  2  2  2  1  2  2  1     1  2  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 3  2  2  1  2  2     2  2  2  2        1  1  2  2  2  1  2  2  1     1  1|             
      Respiratory Epithelium, Hyperplasia  |    2  2  2  3  3     2  2  3  2  1  2  2     2  1  3  3  1  2  2  2  3  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                1                                      1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3|             
                                           | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  1  1  2  3  2  2  2  2  1  2  2  2  1  2  2  2  1  1  3        1  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +     +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Parasite Metazoan                    |                                     X                                    |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  I|  47        |
      Parasite Metazoan                    |                            X                          X        X         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +  +|  46        |
      Parasite Metazoan                    | X           X                                            X               |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Angiectasis                          |                   1                       2                              |      3  1.3|
      Basophilic Focus                     |    X     X  X  X  X  X     X  X  X  X  X     X     X  X  X     X  X  X  X|     34     |
      Clear Cell Focus                     |          X        X        X                                             |      6     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Degeneration, Fatty                  | 2     3                 3                 2                              |     10  2.4|
      Eosinophilic Focus                   |                X  X                    X                                 |      4     |
      Hepatodiaphragmatic Nodule           |             X                       X                                    |      6     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Mixed Cell Focus                     |             X                 X  X  X        X  X     X                 X|      9     |
      Bile Duct, Hyperplasia               | 1     2                                                                  |      6  1.8|
      Centrilobular, Necrosis              | 1                                         2                              |      8  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +        +        +           +               |  11        |
      Fat, Necrosis                        |       3                    3        1        2           1               |     11  2.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                +                                                         |   1        |
      Pharyngeal, Hyperplasia, Squamous    |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Atrophy                              |       2  3     1                    1                                    |     11  1.6|
      Basophilic Focus                     |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis                             |       2                                   3                              |      5  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |       1                                   3  2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  22                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Cardiomyopathy                       |    1                 1     1  1  1  2        2  2  2  1  1     2     2  1|     23  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Angiectasis                          |                                                    2                     |      1  2.0|
      Hyperplasia                          |    1     2     2           2     2           2        2  2        3  2   |     21  1.9|
      Hypertrophy                          |                                  2  2                 2                  |      6  2.2|
      Vacuolization Cytoplasmic            |                                     2                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Hyperplasia                          | 2  1  1  2                          2        3                    3      |     10  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +|  44        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Cyst                                 |                                                                   3      |      1  3.0|
      Pars Distalis, Angiectasis           |       4  3                                                               |      3  3.3|
      Pars Distalis, Hyperplasia           |                            2                                             |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  47        |
      C-Cell, Hyperplasia                  | 2  1  2  3  1  1  2  1  1        1  2     1  1     1     2        1  1  1|     35  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  46        |
      Hyperplasia                          |                                     3                 2                  |      2  2.5|
      Inflammation, Chronic Active         |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Cyst                                 |                         2                                3     3         |      6  2.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                              +                           |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Hyperplasia, Histiocytic             |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +                                                |   8        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  23                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M     +  +  +  M|  40        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Hemorrhage                           |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +|  45        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Accessory Spleen                     |                                                                          |      2     |
      Fibrosis                             |                2                                                         |      3  1.7|
      Hematopoietic Cell Proliferation     |          3                                                               |      2  3.0|
      Hemorrhage                           |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  M  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Galactocele                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Hyperostosis                         | 3     4  2              4                 3                       2      |     12  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |    1  1                    1           1        2                    1   |     13  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Inflammation, Suppurative            |          2                             1  2  1           1               |      5  1.4|
      Thrombosis                           |       3                                                                  |      6  2.2|
      Glands, Hyperplasia                  | 1        1  1  1           1  1                          1     1  1      |     24  1.0|
      Lateral Wall, Hyperplasia            | 2  2  3  2  2  3  2  2  2  2  2  1  2  1  3  2  3  2  2  2     2  1  2  2|     48  2.1|
      Olfactory Epithelium, Atrophy        | 2  1  2  1  2  1  2  2  2  2  2  1  1  1  2  2  1  2  1        1        2|     44  1.7|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  24                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Hyaline                         | 3  3  3  3  4  3  3  3  3  3  3  3  3  2  3  4  2  3  2  3     3  3  2  2|     47  2.7|
      Olfactory Epithelium, Fibrosis       |       1  1        1     1        1     1     1                       1   |     16  1.3|
      Olfactory Epithelium, Hyperplasia    |       1  1     1  1  1  1  1     1     1  1  1     1     1        1  1   |     31  1.2|
      Olfactory Epithelium, Metaplasia     | 1     2  1  1  1  1  1  2  2  1  1  1  1     2     2  1                 1|     37  1.5|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2  2  2  1  2  2  2  3  1  3  2  2  2  1  2  2  2  2  2  4     3  3  2  2|     45  1.9|
      Respiratory Epithelium, Hyperplasia  | 2  2  3     2  1  1  2  2  3  2     2     3  2  3        2     2     2  2|     40  2.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Cataract                             |             3                                                            |      1  3.0|
      Retina, Atrophy                      |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Nephropathy                          | 2  3  2  2  1  2  2  1  2  2  2  3  3  2  2  2  2  2  2  3     2  2  3  2|     47  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Transitional Epithelium, Hyperplasia |                                                          3               |      2  2.5|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  25                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3|             
                                           | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X  X                                                           X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                       X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2        1  2     1                    1                           |             
      Basophilic Focus                     | X        X     X  X     X  X     X  X        X        X     X     X  X  X|             
      Clear Cell Focus                     |                            X                 X                           |             
      Degeneration, Cystic                 |                                                                         2|             
      Degeneration, Fatty                  |    3  2     2        1           3        3        4        3            |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X  X           X                                                   |             
      Mixed Cell Focus                     | X                 X                 X                          X  X      |             
      Necrosis                             |                                                                2         |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |                                        2  2                       1      |             
      Centrilobular, Necrosis              |                                  1     1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                       +  +            |             
      Fat, Necrosis                        |                            2     2                       2  2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1           3           1        2              1               |             
      Basophilic Focus                     |                                                                          |             
      Metaplasia, Hepatocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |    4  4     3     2                       3        3     3  3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |    1  1        1                 3                 3        3            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +        +            |             
      Hyperplasia, Squamous                |                                                             3            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3|             
                                           | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1     1        1  2     1  2        1        1  1                 1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2     2        2        2     2  2        2  1  1           2  2     2|             
      Hypertrophy                          |                                                                         2|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |       3     2                          2     2                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  2                          2        3  2  2              2        3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                            2           2     2           3  3     3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  1     1  1  1     4  4     2  1  1     2     1  1     1  2  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +|             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          1  2  3         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +              +  +                       +            |             
      Renal, Ectasia                       |                                     2                                    |             
      Renal, Hemorrhage                    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  +  M  +  +  +  +  +  +  +  M  M  M  M  +  M  M  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |             2     2                       2                          2   |             
      Hematopoietic Cell Proliferation     |                                                       3  3               |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3|             
                                           | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                2  2                 2     2                              |             
      Hyperplasia, Atypical                |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                           3                              |             
      Tail, Hyperkeratosis                 |                                                       1                  |             
      Tail, Inflammation, Chronic Active   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   1                                                      |             
      Hyperostosis                         | 3           2                    3                                       |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Granulomatous          |                            2                                         2   |             
      Alveolar Epithelium, Hyperplasia     | 1     1  1        1                                2  1        2  1      |             
      Mediastinum, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1     1     2     2  1  2  1     1  3     2              2  2           2|             
      Thrombosis                           |                                                          3               |             
      Glands, Hyperplasia                  | 1  3  3     1  3  3  3  2  3     1  1     1  2  4  1  3  3  2  2  3  3  1|             
      Lateral Wall, Hyperplasia            | 2  4  3  3  4  4  3  4  3  3     4  3  4  3  3  4  2  3  3  4  3  3  3  3|             
      Lateral Wall, Metaplasia, Squamous   |          1  1        1  1        1  1                          1         |             
      Olfactory Epithelium, Atrophy        | 2  2  2  2  2  2  2  3  2  3     2  2  3  2  2  2  2  2  3  2  2  3  2  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  4  3  2  2  3  3  3  4  4     3  3  2  3  3  4  4  4  4  3  4  4  4  3|             
      Olfactory Epithelium, Fibrosis       | 1     2        2           2     1           2  2     2  2  2     1  1   |             
      Olfactory Epithelium, Hyperplasia    | 1  1  2     1  1  1     2  2     1  1  1  1  1  2     2  2  1  1  1  1  1|             
      Olfactory Epithelium, Metaplasia     | 2  2  2  2  2  2  2  2  2  3     2  2  2  1  2  2  2  2  3  2  2  3  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                         2                 2                              |             
      Respiratory Epithelium, Hyperplasia  | 2  3  4  3  3  4  2  4  3  3     4  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3|             
                                           | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Squamous                        |    1  1                                            2     1              1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 3  4  4  2  3  3  4  2  3  3  2  3  3  1  3  2  3  3  2  2  1  3  2  3  3|             
      Renal Tubule, Hyperplasia            |                         2                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                3         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6|            |
                             DAY ON TEST   | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5|            |
                                           | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    X                                                                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |             X           X                                                |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      5  1.4|
      Basophilic Focus                     |    X        X  X                          X  X  X        X              X|     22     |
      Clear Cell Focus                     |             X                                                            |      3     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Degeneration, Fatty                  | 3                          1  1  1     2           3  2     3     1      |     17  2.2|
      Eosinophilic Focus                   |          X                                                               |      1     |
      Hepatodiaphragmatic Nodule           |                                     X                                    |      4     |
      Mixed Cell Focus                     |                X                                X        X               |      8     |
      Necrosis                             |                                                          2               |      2  2.0|
      Regeneration                         |          4                                                               |      1  4.0|
      Bile Duct, Hyperplasia               |          2                    2        1                             2   |      7  1.7|
      Centrilobular, Necrosis              |       1  1                    1  1     1                    1        1   |      9  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +                                         +            |   7        |
      Fat, Necrosis                        |             2                                               3            |      6  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      2              1     1        2           2        1|     11  1.5|
      Basophilic Focus                     |                                                                   X      |      1     |
      Metaplasia, Hepatocyte               |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Necrosis                             |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             | 3                             3     4              3                     |     12  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                      1   |      1  1.0|
      Necrosis                             |                                                                         3|      7  2.1|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   3        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  30                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6|            |
                             DAY ON TEST   | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5|            |
                                           | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
      Degeneration                         |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1     1                    1        1  2           1        1  1   |     19  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2     2     2              2  2     2              2     1           2  2|     23  1.8|
      Hypertrophy                          |             2                                                            |      2  2.0|
      Necrosis                             |                                                             2            |      1  2.0|
      Vacuolization Cytoplasmic            |                            2     3  3                                   2|      8  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       3     2        2              3                 3              1   |     14  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |    2     3                                                     2         |      9  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 1     2  1  1  1     1  1  1  1     1  1  1     1  1  1  1  2     1  1  1|     39  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  45        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 3        1           2                 2                                 |      7  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                 +  +  +                 +     +   |  11        |
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  +  M  +  +  M  M  +  +  M  M  +  +  M  +  M  M  +  M  M  +|  25        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  31                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6|            |
                             DAY ON TEST   | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5|            |
                                           | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +|  40        |
      Hemorrhage                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                             X            |      1     |
      Fibrosis                             |                               3                                          |      5  2.2|
      Hematopoietic Cell Proliferation     |    3              4                                      3               |      5  3.2|
      Inflammation, Granulomatous          |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                        2                                 |      5  2.0|
      Hyperplasia, Atypical                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                             3            |      1  3.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  3.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  1.0|
      Tail, Inflammation, Chronic Active   |             3                                         2  1           3   |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|
      Hyperostosis                         | 2                    4        3                                          |      6  2.8|
      Inflammation, Chronic                |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                         X|      1     |
      Inflammation, Granulomatous          |                                                                         4|      3  2.7|
      Alveolar Epithelium, Hyperplasia     |                1     1                    2                          2   |     12  1.3|
      Mediastinum, Inflammation,           |                                                                          |            |
          Granulomatous                    |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  32                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6|            |
                             DAY ON TEST   | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5|            |
                                           | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            | 3                       2     1  2     1        1     1     2        3  2|     23  1.7|
      Thrombosis                           | 3                             4        2                    3            |      5  3.0|
      Glands, Hyperplasia                  | 2  2  2  1  3  3  1  2     2  2  2  3  1  3  2  2  3  3  2  4  3  2  2  2|     46  2.2|
      Lateral Wall, Hyperplasia            | 4  3  3  3  3  4  3  3  3  4  4  4  4  3  2  3  4  3  3  4  4  3  3  4  2|     49  3.3|
      Lateral Wall, Metaplasia, Squamous   | 1  1     1  1  1     1     1     1     1     1  1     1  2  1  1  1  1   |     24  1.0|
      Olfactory Epithelium, Atrophy        | 2  3  2  2  3  2  2  3  2  2  2  3  2  2  2  2  2  3  3  3  3  3  2  2  2|     49  2.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 4     3  3  4  3  3  3  3  4  2  3  3  3  3  4  4  4  4  3  4  4  4  2  3|     48  3.3|
      Olfactory Epithelium, Fibrosis       |    1  1     2  2     3     1  2  2  2     2  2     2  1  2  1  2  1  2  2|     31  1.7|
      Olfactory Epithelium, Hyperplasia    |    2  2  1  2  2           1  2  2  2  1  2  2  2  2  1  2     3  2  2  1|     41  1.5|
      Olfactory Epithelium, Metaplasia     | 2  3  2  1  3  2     3  2  2  2  3  2  2  2  2  2  3  3  3  3  3  2  2  2|     48  2.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    3     1                                      1  3                     |      6  2.0|
      Respiratory Epithelium, Hyperplasia  | 4  4  4  3  4  4  3  3  3  4  4  4  4  3  3  2  3  3  3  3  3  3  3  4  3|     49  3.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             1        1           2  1                    1               |     10  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     3                                    |      1  3.0|
      Nephropathy                          | 1  1  1  1  3  2  2  3     3  2  2  4  3  2  2  3  2     2  1     3  2  3|     47  2.4|
      Renal Tubule, Hyperplasia            |                                                                         3|      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  33                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6|             
                             DAY ON TEST   | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9|             
                                           | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                        X                          X      |             
      Clear Cell Focus                     |                                           X              X               |             
      Degeneration, Cystic                 | 2                                2  3  2                                1|             
      Degeneration, Fatty                  |          4              1                                            1   |             
      Eosinophilic Focus                   |                                                                          |             
      Regeneration                         |                            3                                             |             
      Vacuolization Cytoplasmic, Focal     |                                  2                                       |             
      Bile Duct, Hyperplasia               | 3           2  2  2  1     3           1           1  4     2  1  2     3|             
      Centrilobular, Necrosis              | 2  1     1           1  1  3                                1           2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +     +     +              +              +        +     +|             
      Fat, Necrosis                        |                3     2     2              2              2        2     2|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2        2     2  1                 1              2  1  1  2         |             
      Basophilic Focus                     |                            X                                             |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    4     4                       3                             3  3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             | 2                    2  2        3                             2        2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6|             
                             DAY ON TEST   | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9|             
                                           | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3     2  3              2  1  2  3  1  2     1  3  2  2           1  2|             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   | 4                                                        2        4      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2              2     2              2         |             
      Hypertrophy                          |                                                    1                     |             
      Vacuolization Cytoplasmic            |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     3  3     2  2     1  2     3     2  3        2        1  2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2  2                    1               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        1  1                             1        3  1        2  1  1  1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2     2               |             
      Inflammation, Chronic Active         |             4              3                       3  2              4   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                 1                        |             
      Interstitial Cell, Hyperplasia       |       1                       1                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +  +     +                                   +        +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6|             
                             DAY ON TEST   | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9|             
                                           | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  M  +  M  M  +  +  M  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                         X|             
      Fibrosis                             | 2                                   2              2     2        2      |             
      Hematopoietic Cell Proliferation     |                                           3                              |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis                             |                   4        3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  M  M  M  +  M  M  +  M  M  M  +  +  +  +  M  M  M  +  M|             
      Degeneration                         |                                     3                                    |             
      Galactocele                          | 2              2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   3      |             
      Tail, Hyperkeratosis                 |                            3                                             |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                           1                              |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          2                 1                             1     3     1   |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
      Thrombosis                           | 3                 2  2     2                          2     1     2      |             
      Lateral Wall, Hyperplasia            |                                                                          |             
      Lateral Wall, Metaplasia, Squamous   |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6|             
                             DAY ON TEST   | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9|             
                                           | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lateral Wall, Necrosis               |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                1  1  1  1  1  1  2     1  1  1  1  1  1  1  1  2  1  2  1|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                         1  1              1     1           1  1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         2|             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 3  4  2  4  3  2  2  3  2  3  1  4  4  2  4  2  3  4  2  3  1  3  3  3  3|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                    1           2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    4                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6|            |
                             DAY ON TEST   | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0|            |
                                           | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |          X        X                                            X         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |    X                             X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1  2        1                 1           1           1               |      6  1.2|
      Basophilic Focus                     |          X              X  X  X  X                    X  X               |      9     |
      Clear Cell Focus                     |                      X                                X                 X|      5     |
      Degeneration, Cystic                 |    2     3     1                 2     2  1        2                     |     12  1.9|
      Degeneration, Fatty                  | 4              1                                                         |      5  2.2|
      Eosinophilic Focus                   |       X     X                                X     X                     |      4     |
      Regeneration                         |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  3  1  1     2     2        2     2           3        2  2  1  3  1|     28  2.0|
      Centrilobular, Necrosis              |    1                                               1     2  1            |     12  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +           +  +                           |  11        |
      Fat, Necrosis                        |                               2           2  2                           |     10  2.1|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   1        |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1  2  3  1              1     2        2  2  1     2  1     2         |     22  1.6|
      Basophilic Focus                     |       X              X                                                   |      3     |
      Hyperplasia                          |                         3                 2              2     2  1      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                               2                                          |      1  2.0|
      Mineralization                       |                   2                                                      |      1  2.0|
      Necrosis                             | 1                                      3  2        2                     |      9  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                   4                       2                              |      2  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  38                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6|            |
                             DAY ON TEST   | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0|            |
                                           | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                    2                     |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +                       +                              |   2        |
      Aorta, Mineralization                |                   4                       1                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     1  3  3  2  3  3  2  2  1  3     2  2  3  3  1  3  3  1  2  2     1|     38  2.1|
      Artery, Mineralization               |                   4                       2                              |      2  3.0|
      Atrium, Thrombosis                   |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2     1  2     1        2  2  2           2        2              2  2|     15  1.9|
      Hypertrophy                          |                         2                                3               |      3  2.0|
      Vacuolization Cytoplasmic            |                2        2        2                                       |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3  2  2  3  3        2  2     2     2  3  2  3  3  2     2  4     2   |     30  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                3  3     2                    2  2        2               |      9  2.1|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                   2                                                      |      1  2.0|
      Pars Distalis, Hemorrhage            |                                                          4               |      1  4.0|
      Pars Distalis, Hyperplasia           |       3                                            3                 2   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          1  2        3  1  1  2  1  1  1     1     1  1  1     1  1  1  1|     27  1.3|
      Follicular Cell, Hyperplasia         |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                          2               |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2                                      3        2              2  1|      7  2.0|
      Inflammation, Chronic Active         |             2  3  3                       3                              |      9  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  39                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6|            |
                             DAY ON TEST   | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0|            |
                                           | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                3         |      1  3.0|
      Artery, Inflammation, Chronic Active |                         2  2                                             |      3  1.7|
      Interstitial Cell, Hyperplasia       |                                                 1                 1      |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                     +              +  +     +            |  10        |
      Renal, Hemorrhage                    |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Infiltration Cellular, Plasma Cell   |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                             X        X   |      3     |
      Fibrosis                             |       2           2              2              2  2  2  2  2           1|     14  1.9|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                              4                           |      1  4.0|
      Necrosis                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  M  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  M  +|  30        |
      Degeneration                         |                                                                          |      1  3.0|
      Galactocele                          |                               2  2           3                 3         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  3.0|
      Tail, Inflammation, Chronic Active   |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   3                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  40                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6|            |
                             DAY ON TEST   | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0|            |
                                           | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                   4                                                      |      1  4.0|
      Alveolar Epithelium, Hyperplasia     | 1     2                    1     1                 3  3        1         |     12  1.7|
      Artery, Mediastinum, Mineralization  |                   3                                                      |      1  3.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         1                 1                              |      3  1.0|
      Thrombosis                           |                                     2                          1     1   |     10  1.8|
      Lateral Wall, Hyperplasia            |                   1                                                      |      1  1.0|
      Lateral Wall, Metaplasia, Squamous   |                                                                          |      1  1.0|
      Lateral Wall, Necrosis               |                   2                                                      |      1  2.0|
      Olfactory Epithelium, Atrophy        |                         1                                                |      1  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  2  1  1  1  1  1  2  2  2  1  2  1  2     2  2     2  2  1  1  1  1  1|     42  1.3|
      Olfactory Epithelium, Metaplasia     |                         1                                                |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |          1        1                 1           1              1     1   |     12  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                                             2            |      1  2.0|
      Mineralization                       |                   3                       3                              |      2  3.0|
      Nephropathy                          | 4  3  2  4  3  4  4  4  4  3  3  4  2  2  3  3  3  2  4  4  2  3  3  2  2|     50  2.9|
      Papilla, Necrosis                    |                                           3                              |      1  3.0|
      Renal Tubule, Hyperplasia            |          3     4  4                                                      |      5  2.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis                             |                                           4                              |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  41                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9|             
                                           | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2  1   |             
      Basophilic Focus                     | X                    X        X                             X     X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |    3     2  2           2     2     2              2              1      |             
      Degeneration, Fatty                  |                      2     2           1           1                    3|             
      Eosinophilic Focus                   |                      X     X                                             |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Mixed Cell Focus                     | X                                                                        |             
      Necrosis                             |                                                 2                        |             
      Regeneration                         | 4                                   2              2                     |             
      Bile Duct, Hyperplasia               | 3  2  2  2  3        1  1     2     3     2  2  1  3  3  2               |             
      Centrilobular, Necrosis              |       2  1  2                       1     2  2     1  1  1               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                    +  +           +                             +      |             
      Artery, Mineralization               |                      4                                                   |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        | 3                       2           2                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     3     3     1        1  1  2     1  1        2  3  2  2  1         |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
      Inflammation, Chronic Active         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                      3                                                   |             
      Necrosis                             |                      4  3  4                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9|             
                                           | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
      Aorta, Mineralization                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  1  2        3  3  1  1        2        1  2        1  1  2  1   |             
      Artery, Mineralization               |                      3                                                   |             
      Atrium, Thrombosis                   |    1  3     3        3                       2        2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        2           2        2           2     2  2  2  2     2      |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                      2                                2                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2           2           1     2     3  3        3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4                 4  2     3                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 3  2                                         3     3     3        3      |             
      Pars Intermedia, Hyperplasia         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1     1  1  1  1  1     1  1  1  1  1     1  1  1     1  1  2     1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Chronic Active         |                   4     3        2              4                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                      2                                                   |             
      Interstitial Cell, Hyperplasia       |                   1                    2                       2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9|             
                                           | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                  +     +              +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  M  M  +  M  +  +  +  M  +  +  +  +  M  +  +  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2  2     2     1     3                             2  2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  M  M  +  +  +|             
      Cyst                                 |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  +  +  +  M  M  +  M  M  M  M  +  +  +  +  M  M  +  M  M|             
      Galactocele                          |                      3                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |    X                                                                     |             
      Inflammation, Acute                  |                                        4                                 |             
      Inflammation, Chronic Active         |    3                             4                                       |             
      Necrosis                             |                                  4                                       |             
      Subcutaneous Tissue, Edema           |    3                                                                     |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2                 4  1                                                |             
      Hyperostosis                         |       1                       3                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Granulomatous          |                                                 2                        |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9|             
                                           | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                      3                                                   |             
      Thrombosis                           |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia     |             1     1     1                                            1   |             
      Artery, Mediastinum, Mineralization  |                      4                                                   |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                                            1      |             
      Thrombosis                           |       3  1  3                             3  3        4     3            |             
      Lateral Wall, Hyperplasia            | 2  2  2  2  1  1  1  2  1  1  1  1  1  1  2  2  1  2  2  2  2  1  1  1  1|             
      Lateral Wall, Metaplasia, Squamous   |                      1                                                   |             
      Olfactory Epithelium, Atrophy        |    1  1           1                    1  1                 1            |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    2  1  1  2  2  2  1  1  1  1  2  1  1  1  1  1  2  2  1  1  1  2  1  1|             
      Olfactory Epithelium, Fibrosis       |                                        1                                 |             
      Olfactory Epithelium, Hyperplasia    |                                        1                                 |             
      Olfactory Epithelium, Metaplasia     | 2                    1                    1                 1            |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |             1  1  1              1  1     1           1           1      |             
      Respiratory Epithelium, Hyperplasia  | 2  2  2  2     1     3                       2  1     2  2  2        1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +              +     +                                 |             
      Cataract                             |                   4                                                      |             
      Inflammation, Chronic Active         |                                  4     4                                 |             
      Retina, Atrophy                      |                   4                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
      Inflammation, Chronic Active         |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2  3                                                |             
      Infarct                              |             2                                2                           |             
      Mineralization                       |                      4                                                   |             
      Nephropathy                          | 2  4  3  2  3  3  3  4  4  2  4  2  3  2  3  3  4  3  4  2  3  3  4  4   |             
      Renal Tubule, Hyperplasia            |                      1        2                          2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   3                                                      |             
      Transitional Epithelium, Hyperplasia |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7|            |
                             DAY ON TEST   | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3|            |
                                           | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                                X                                    |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                       X                                             |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                       X                  |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |                                  X  X           X  X                    X|     12     |
      Clear Cell Focus                     |                                     X                                    |      1     |
      Degeneration, Cystic                 |                2  1           2  3  2        4  2     2           1  1   |     18  2.0|
      Degeneration, Fatty                  | 1     1     4                    1                                       |      9  1.8|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                    3                     |      2  2.5|
      Regeneration                         |                                                                          |      3  2.7|
      Bile Duct, Hyperplasia               | 1     1  3           2  1  2  4        2  2  2  3     3  3  3     2     2|     31  2.2|
      Centrilobular, Necrosis              |          1           1     1           1              2  1  1     1      |     17  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                 +        +           +        +  +  +      |  13        |
      Artery, Mineralization               |                                                    3                     |      2  3.5|
      Fat, Hemorrhage                      |          2                                                        2      |      2  2.0|
      Fat, Necrosis                        |             2                          3                       2         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1        2                          2  1        3  2     1        1|     22  1.8|
      Basophilic Focus                     |                                                                         X|      1     |
      Hyperplasia                          |                                                          2        2      |      2  2.0|
      Artery, Inflammation                 |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                             1            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  46                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7|            |
                             DAY ON TEST   | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3|            |
                                           | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
      Mineralization                       |                                                    2                     |      2  2.5|
      Necrosis                             |                   3                             3              4         |      6  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                    3                     |      2  3.5|
      Necrosis                             |                                                       1  3               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                    +                     |   2        |
      Aorta, Mineralization                |                                                    3                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2  2  1        2  2  2  2  3  2           2  3  1  2     1        2|     32  1.7|
      Artery, Mineralization               |                                                    4                     |      2  3.5|
      Atrium, Thrombosis                   |                                                                          |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2  1        2           2              2  2           2     2  2|     19  1.9|
      Hypertrophy                          |          2        2                             2                        |      3  2.0|
      Vacuolization Cytoplasmic            |                                                                3         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3  2  3           3        2     2           4     2     1  3|     17  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +|  45        |
      Hyperplasia                          |                                                 2                        |      5  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                      2                 2                                 |      8  2.6|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 1  1  1     1     1              1  1  2  1  1  1        1  1     1      |     33  1.1|
      Follicular Cell, Hyperplasia         |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  47                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7|            |
                             DAY ON TEST   | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3|            |
                                           | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     1                    2               |      3  1.7|
      Inflammation, Chronic Active         |                3                 3                       3           3   |      8  3.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                2         |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |             1  1           2                                             |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                       3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +                                +     +                  |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  M  +  +  M  M  +  M  +  +  M  M  +  M  +  +  +  M  M|  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  42        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                      2                 2        4     2     4     2      |     13  2.3|
      Hematopoietic Cell Proliferation     |    2                                2                                    |      2  2.0|
      Necrosis                             |                               4                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|  40        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  +  +  +  M  M  M  +  M  +  M  M  +  +  +  +  M  +  +  +  +  M|  25        |
      Galactocele                          |                                                                2         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                          X               |      2     |
      Inflammation, Acute                  |                                        2                                 |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Necrosis                             |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Tail, Inflammation, Chronic Active   |             3     2                                                      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  48                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7|            |
                             DAY ON TEST   | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3|            |
                                           | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |                                                 1  3                     |      5  2.2|
      Hyperostosis                         |                               3        3                    2            |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                       2           3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                      X   |      1     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                      4   |      1  4.0|
      Metaplasia, Squamous                 |                               2                                          |      1  2.0|
      Mineralization                       |                                                    3                     |      2  3.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          1                                   1                 1         |      7  1.0|
      Artery, Mediastinum, Mineralization  |                                                    3                     |      2  3.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          2           1                          2  1                     |      6  1.5|
      Thrombosis                           |          1           2        4        3     3        2  4  1            |     15  2.7|
      Lateral Wall, Hyperplasia            | 1     1  2  1  1  2  2  1  2  3  1  1  2  1  2  1  1  2  2  2  1  3  1  1|     49  1.5|
      Lateral Wall, Metaplasia, Squamous   |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        | 1     2  1  1        1                                      1            |     12  1.1|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |    2  2  1  2  2  2  2  2  2  2  1  2  2  1  2  2  1  2  1  2  1  2  1  1|     48  1.5|
      Olfactory Epithelium, Fibrosis       |                                                                          |      1  1.0|
      Olfactory Epithelium, Hyperplasia    |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |       2     1        1                                      1            |      8  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                      1  1  1  1  1                                      1|     14  1.0|
      Respiratory Epithelium, Hyperplasia  |       1  1  1     2  2  1  2  2        2     2        2  2  2     3      |     26  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  49                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7|            |
                             DAY ON TEST   | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3|            |
                                           | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 2                                                                        |      3  2.3|
      Infarct                              |                                                                          |      2  2.0|
      Mineralization                       |                                                    2                     |      2  3.0|
      Nephropathy                          | 3  1  2  3  4  2  2  3  2  2  3  3  2  2  2  3  4  4  3  3  2  4  3  3  3|     49  2.9|
      Renal Tubule, Hyperplasia            |                      3                             2                     |      5  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  50                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8|             
                                           | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                   X                                            X     X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X  X  X                          X                       X        X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              3           2        2      |             
      Basophilic Focus                     | X  X  X        X  X     X  X     X  X  X  X        X     X     X  X  X   |             
      Clear Cell Focus                     | X  X                                                                     |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |       1     3  3  1                          2        3        2         |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |       X                                      X        X                  |             
      Hepatodiaphragmatic Nodule           |       X           X                       X                              |             
      Mixed Cell Focus                     |                                                       X                  |             
      Regeneration                         |                                                                   3      |             
      Tension Lipidosis                    |          X                                                               |             
      Bile Duct, Hyperplasia               | 2  1  1     2     3     1  1  2     2     2  3     2  3  1  2  3  2  3  2|             
      Centrilobular, Necrosis              |                      3        2           2           1     1        2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +                 +  +           +                     |             
      Pigmentation                         |                   4                                                      |             
      Fat, Hemorrhage                      |             2                                                            |             
      Fat, Necrosis                        |                                     3  2           3                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                          +               |             
      Pharyngeal, Hyperplasia              |                                                          4               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     2           2  2     1        2  1     2        3     1     3  3   |             
      Basophilic Focus                     |          X                       X                                       |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            3                                             |             
      Necrosis                             |             4  4                                4                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             3              4                                             |             
      Necrosis                             |       2     3        2                                         2         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8|             
                                           | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +           +                                 |             
      Aorta, Mineralization                |                            4                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  1  3  2  2     3  4     3  3  3  2  2     2  1  2  1  2  2  1   |             
      Artery, Mineralization               |                            4                                             |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3           1  3     2        2     2           2  2                 2|             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                            3                    3                        |             
      Vacuolization Cytoplasmic            |             2                    2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2        3     3  1  3  2     3  3  2  2              2        3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2           2  4                    3  2  2        2         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                           4                             2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     1  1        1  1        1     2  1  1  1  1  2  1  1     1     1|             
      Follicular Cell, Hyperplasia         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                3        3                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 2                 2        2                    3      |             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
      Artery, Inflammation, Chronic Active |             1  3                       2                                 |             
      Interstitial Cell, Hyperplasia       |          2                    1                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8|             
                                           | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +           +     +     +           +              +  +|             
      Renal, Hemorrhage                    |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  +  +  +  +  M  +  +  M  M  +  M  M  +  M  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |             2                    2                    3        3        2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                      4   |             
      Necrosis                             |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Degeneration                         |                                                                          |             
      Galactocele                          |                                     2                 2           3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            1                          3                  |             
      Inflammation, Granulomatous          |       4                                                                  |             
      Tail, Inflammation, Chronic Active   | 3                 3                 3                             3  3   |             
      Tail, Subcutaneous Tissue, Thrombosis|                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             2  2        2  4                    2                        |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                            4                                             |             
      Alveolar Epithelium, Hyperplasia     |                   1                    3                          1      |             
      Artery, Mediastinum, Mineralization  |                            4                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1        1  1        2  2  2  1     2  2  2           1   |             
      Thrombosis                           |                               3           3  1              4        2  4|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  53                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8|             
                                           | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Hyperplasia                  |          1  1     1  1              1              1  1  1  1  1        1|             
      Lateral Wall, Hyperplasia            | 2  3  3  2  2  2  2  2  3  2  3  3  3  3  3  3  2  2  2  2  2  2  2  2  2|             
      Lateral Wall, Metaplasia, Squamous   |                      1                          1                        |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Atrophy        | 1  1     2  1     2  2  2  1  2  2  2  2  2  2  2  1  1  2  2  2  2  2  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  3  2  3  2  2  3  3  3  2  2  2  3  3  3  3  3  2  2  3  3  3  2  2  3|             
      Olfactory Epithelium, Fibrosis       |       1  1  1     1  2  1        1  1           1                    1   |             
      Olfactory Epithelium, Hyperplasia    | 1  1  1  1  1     1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1   |             
      Olfactory Epithelium, Metaplasia     | 1  1     1        1  2  2  1  1  2  2  2  2  2  1     1  1  2  1  2  1  1|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1  2  2  2  1  2  2  2  2  1  2  1  2  1  2  2  2  2  2  2  1  1  1  1  1|             
      Respiratory Epithelium, Hyperplasia  | 2  2  2  2  2  3  2  3  2  2  2  2  3  2  3  3  3  3  3  3  2  2  2  3  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |             2                                                  2         |             
      Mineralization                       |                            4                                             |             
      Nephropathy                          | 3  3  3  2  4  4  4  4  4  4  2  4  4  4  2  3  4  4  4  2  2  4  4  2  2|             
      STROMAL HYPERPLASIA                  |       3                                                                  |             
      Renal Tubule, Hyperplasia            |             1  2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  54                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3|            |
                                           | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                   3      |      1  3.0|
      Parasite Metazoan                    | X              X                       X                                 |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                X                                            X        X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  44        |
      Parasite Metazoan                    |                   X                                                  X   |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  43        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      3  2.3|
      Basophilic Focus                     |    X  X              X  X        X              X           X  X  X  X  X|     27     |
      Clear Cell Focus                     |                                                                   X     X|      4     |
      Cyst                                 | 2                                   2                                    |      2  2.0|
      Degeneration, Cystic                 |       1                                         3  2     2        3      |     12  2.2|
      Degeneration, Fatty                  |          2                 1                                            2|      3  1.7|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                                                                   X      |      4     |
      Mixed Cell Focus                     |                            X                                             |      2     |
      Regeneration                         |                                                 4                        |      2  3.5|
      Tension Lipidosis                    |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2  3  1                       2     2     2     3  3  2        3     1   |     30  2.1|
      Centrilobular, Necrosis              | 2                                1  1     1     1  1  1        1         |     15  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +        +        +           +|   9        |
      Pigmentation                         |                                                                          |      1  4.0|
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                           2        2        2           2|      7  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2  1  1                 2  1           3  2  1        2     2  3|     23  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Artery, Mineralization               |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  55                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3|            |
                                           | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                   3      |      2  3.0|
      Necrosis                             |       3                    3     2  2                    2        2     2|     10  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                   4      |      3  3.7|
      Necrosis                             |                                                                          |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                   +      |   3        |
      Aorta, Mineralization                |                                                                   4      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1  2  2  2  2  2  2  1     1  1  1           2  1  1  2  2  3  2  2|     40  1.9|
      Artery, Mineralization               |                                                                   4      |      2  4.0|
      Atrium, Thrombosis                   |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2     2  2        2           1              3  2  2  2  2|     20  2.1|
      Hypertrophy                          |                                                    2                     |      1  2.0|
      Necrosis                             |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic            |                                           1     3                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2        1              2  2              2  2  2     2     4        2  2|     24  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                             2                    3     3     2|     12  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Pars Distalis, Hyperplasia           |                   2                                                      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |    1     1              1  1     2  1  1  1  1     1  1        1        1|     30  1.1|
      Follicular Cell, Hyperplasia         |                                                             2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  56                                                               
NTP Experiment-Test: 05201-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:16:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3|            |
                                           | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      5  2.2|
      Inflammation, Chronic Active         |          3              1                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +|  46        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               3                                      3   |      3  3.0|
      Artery, Inflammation, Chronic Active |                                                                      3   |      4  2.3|
      Interstitial Cel