TDMS Study 05201-05 Pathology Tables
NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 2 YEAR CHRONIC FINAL #2 Facility: Battelle Northwest Chemical CAS #: 0098-00-0000 Lock Date: 01/26/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Cyst | 4 | Degeneration, Fatty | 1 1 3 2 3 1 2 3| Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X | Infiltration Cellular, Histiocyte | | Mixed Cell Focus | X X X | Necrosis | 1 | Thrombosis | | Bile Duct, Hyperplasia | 2 1 2| Centrilobular, Necrosis | 1 1 1| __________________________________________________________________________| Mesentery | + + + + + + | Fat, Hemorrhage | | Fat, Necrosis | 2 2 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| Atrophy | 1 4 2 1 2 1 2| Basophilic Focus | X X | Hyperplasia | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Necrosis | 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Necrosis | | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | | Pulp, Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 2 1 2 2 2 1 1 1 2 2 | Atrium, Thrombosis | 1 3 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hyperplasia | 1 2 2 2 2 2 1 2 3 2 | Hypertrophy | | Necrosis | 2 | Vacuolization Cytoplasmic | 2 2 3 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 3 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 1 2 1 2 2 2 2 1 2 1 2 2 2 1 1 1 2 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + + + + + M + M + + + + + M + + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 3| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 3 3| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| Hyperplasia, Histiocytic | | __________________________________________________________________________| Lymph Node | +| __________________________________________________________________________| Lymph Node, Bronchial | + + M M + + M + + + + + + + + + + M + M M + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + M M| __________________________________________________________________________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| Fibrosis | 3 2 1 | Hematopoietic Cell Proliferation | 2 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 2| Hyperplasia, Focal | 3 | Inflammation, Granulomatous | 3 | Metaplasia, Lipocyte | 3 | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 1 3 3 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2| Inflammation, Granulomatous | 2 | Inflammation, Suppurative | | Alveolar Epithelium, Hyperplasia | 1 1 1 | Perivascular, Infiltration Cellular, | | Mononuclear Cell | 1 | __________________________________________________________________________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Thrombosis | 4 1 1 4| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 1 1 2 2 1 1 1 1 2 1 2 1 1 1 1 1| Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | Retina, Atrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2| Infiltration Cellular, Histiocyte | | Nephropathy | 2 2 1 2 2 1 2 2 2 2 3 2 2 2 2 1 2 2 2 3 2 3 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + I + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 2.3| Basophilic Focus | X X X X X X X X X X X X| 30 | Clear Cell Focus | X X X | 5 | Cyst | | 1 4.0| Degeneration, Fatty | 3 2 3 1 1 | 13 2.0| Eosinophilic Focus | X | 3 | Hepatodiaphragmatic Nodule | X X X | 4 | Infiltration Cellular, Histiocyte | 2 | 1 2.0| Mixed Cell Focus | X X X X X X | 9 | Necrosis | | 1 1.0| Thrombosis | 2 | 1 2.0| Bile Duct, Hyperplasia | 2 1 1 | 6 1.5| Centrilobular, Necrosis | 1 1 1 | 6 1.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 15 | Fat, Hemorrhage | 2 | 1 2.0| Fat, Necrosis | 3 2 2 2 2 3 2 | 13 2.2| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 1 3 | 10 1.8| Basophilic Focus | X X | 4 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Necrosis | 3 3 3 | 5 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | + | 1 | Pulp, Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 2 2 1 1 1 1 1 2| 29 1.3| Atrium, Thrombosis | | 3 1.7| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Hyperplasia | 1 2 2 2 1 1 2 2 2| 19 1.8| Hypertrophy | 1 2 | 2 1.5| Necrosis | 3 3 2 | 4 2.5| Vacuolization Cytoplasmic | 2 | 5 2.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 1 1 3 2 2 2 | 12 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + M + +| 46 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 1 3 1 4 | 8 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 2 1 1 1 1 1 2 2 1 2 2 1 3 1 1 1| 40 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + M| 44 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 2 | 2 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 3 3.3| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Histiocytic | 4 4| 2 4.0| __________________________________________________________________________|____________| Lymph Node | + + + | 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + + M + + + + + M + M + M + M + + + + M +| 37 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + M + + M + + + + + + + + + + M +| 46 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + + M + + + + + + + + M + + + M + + + +| 43 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 3 | 5 2.2| Hematopoietic Cell Proliferation | 3 | 2 2.5| Hemorrhage | | 1 2.0| Hyperplasia, Focal | | 1 3.0| Inflammation, Granulomatous | | 1 3.0| Metaplasia, Lipocyte | | 1 3.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + M +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 3 | 3 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 3 4 3 | 8 2.6| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epiglottis, Metaplasia, Squamous | 3 | 1 3.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 3 | 2 2.5| Inflammation, Granulomatous | | 1 2.0| Inflammation, Suppurative | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 2 2 1 1 3 | 9 1.4| Perivascular, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Mononuclear Cell | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 2 2 4 | 4 2.3| Thrombosis | 4 3 2 | 7 2.7| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 2 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.2| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 4 | 1 4.0| Retina, Atrophy | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 | 2 2.0| Infiltration Cellular, Histiocyte | 2 | 1 2.0| Nephropathy | 2 2 2 2 2 1 2 1 1 2 2 3 3 2 2 2 1 2 2 2 1 2 2 2| 47 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + A + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + A + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Degeneration, Fatty | 2 2 3 2 | Eosinophilic Focus | | Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X X X X X| Mixed Cell Focus | X X X X X X | Necrosis | | Regeneration | | Vacuolization Cytoplasmic, Focal | 2 | Bile Duct, Hyperplasia | | Centrilobular, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 1 | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Hyperplasia, Squamous | | __________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 1 2 2 2 2 2 2| Basophilic Focus | X | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 3 | Necrosis | 3 1 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 3 | Necrosis | 2 3 | __________________________________________________________________________| Tongue | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 2 | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 2 2 2 2 1 1 1 1 1 1 1| Artery, Mineralization | 2 | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | | Hyperplasia | 1 1 2 2 2 | Hypertrophy | 2 3 | Necrosis | 3 | Vacuolization Cytoplasmic | 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + A + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + M M + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 2 3 2| __________________________________________________________________________| Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 1 2 3 2 2 3 2 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + M + M + + + +| Hyperplasia | 1 3 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| Hyperplasia, Histiocytic | 4 | __________________________________________________________________________| Lymph Node | + + | Renal, Hemorrhage | 1 | __________________________________________________________________________| Lymph Node, Bronchial | M M + + M M + + + M + M M + + M + + M M + + M + +| __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + M M M + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + M M M + + + + + + M + + M + + + + + + + + M| __________________________________________________________________________| Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrosis | 3 | Hematopoietic Cell Proliferation | 4 4 | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + M M + + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 1 | Necrosis | 4 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 | Hyperostosis | 3 1 1 1 4 4 3| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 3 1 2 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Thrombosis | 4 | Lateral Wall, Hyperplasia | 1 1 1 1 2 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1| Lateral Wall, Metaplasia, Squamous | 1 | Olfactory Epithelium, Atrophy | 1 2 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 2 1 1 3 2 1 2 2 2 2 2 2 1 1 1 1 1 2 1 2 1 1 2| Olfactory Epithelium, Metaplasia | 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1| Respiratory Epithelium, Hyperplasia | 2 1 2 1 1 1 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Hydronephrosis | | Infarct | | Mineralization | 2 | Nephropathy | 2 2 1 3 4 1 1 3 1 1 2 2 1 2 2 1 2 2 1 2 2 2 3| __________________________________________________________________________| Urinary Bladder | + + + + + + + I + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +| 47 | Parasite Metazoan | X X| 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 | 2 1.0| Basophilic Focus | X X X X X X X X X X X X X X X X | 31 | Clear Cell Focus | X X | 6 | Degeneration, Fatty | 3 1 2 3 3 | 9 2.3| Eosinophilic Focus | X X | 2 | Hematopoietic Cell Proliferation | | 1 2.0| Hepatodiaphragmatic Nodule | X | 7 | Mixed Cell Focus | X X X X X X X | 13 | Necrosis | 3 | 1 3.0| Regeneration | 3 | 1 3.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| Bile Duct, Hyperplasia | 3 1 1 2 2 3 1| 7 1.9| Centrilobular, Necrosis | 1 1 2 1 1 | 6 1.2| __________________________________________________________________________|____________| Mesentery | + + + + + + | 8 | Fat, Necrosis | 2 3 2 1 2 2 | 7 1.9| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Hyperplasia, Squamous | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 2 | 11 1.8| Basophilic Focus | | 1 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | | 1 3.0| Necrosis | 3 1 | 6 2.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | | 2 2.0| Necrosis | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tongue | + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Mineralization | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 1 1 2 1 1 1 1 2| 24 1.3| Artery, Mineralization | | 1 2.0| Atrium, Thrombosis | 3 2 | 3 2.7| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 3 | 1 3.0| Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 1 2 2 1 2 3 | 22 1.8| Hypertrophy | 2 2| 4 2.3| Necrosis | | 1 3.0| Vacuolization Cytoplasmic | 2 | 3 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 3 2 | 7 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + M M + + + M + + + + + +| 43 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 2 2 2 3 3 | 10 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 1 2 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2| 41 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M + + M + + + + + + + + + M| 45 | Hyperplasia | 2 2 2 | 5 2.0| Inflammation, Chronic Active | 3 3 | 3 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1 1 3 | 5 2.2| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Hyperplasia, Histiocytic | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + | 5 | Renal, Hemorrhage | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M M M + + + + M + + + + + M M M + M + + + +| 30 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M + + + + + + M M + + + + M + + + + M + + +| 37 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 3 | 3 2.7| Hematopoietic Cell Proliferation | 4 3 | 4 3.8| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + M + + + + + + + + + + + + + M +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Galactocele | | 2 2.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 1.0| Hyperostosis | 2 3 1 2 3 2 3 | 14 2.4| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 2 1 3 1 1 | 16 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 1 2.0| Thrombosis | 3 2 | 3 3.0| Lateral Wall, Hyperplasia | 2 1 1 1 2 2 2 1 2 1 2 1 1 1 1 1 1 2 1 | 39 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lateral Wall, Metaplasia, Squamous | | 1 1.0| Olfactory Epithelium, Atrophy | 1 1 2 | 6 1.3| Olfactory Epithelium, Degeneration, | | | Hyaline | 3 2 2 2 2 2 2 3 3 2 1 1 1 1 1 1 1 2 2 1 2 1 1 1 2| 50 1.6| Olfactory Epithelium, Metaplasia | 1 1 2 | 5 1.2| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 2 1 2 1 3 1 1 1 1 2 2 1 1 1 1| 39 1.2| Respiratory Epithelium, Hyperplasia | 1 1 2 1 2 2 2 2 1 1 | 18 1.4| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hydronephrosis | 1 | 1 1.0| Infarct | 1 | 1 1.0| Mineralization | | 1 2.0| Nephropathy | 1 1 2 2 2 1 2 1 3 2 2 2 2 2 2 2 2 3 2 2 2 2| 45 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + M M + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + A + +| Parasite Metazoan | X X X X X| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | X X X | Degeneration, Cystic | 2 | Degeneration, Fatty | 1 3 3 2 2 3 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X X | Inflammation, Granulomatous | 2 | Mixed Cell Focus | X | Bile Duct, Hyperplasia | 2 2 2 2 | Centrilobular, Necrosis | 1 1 1 1 2 1 | __________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis | 2 2 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Hyperplasia, Squamous | | __________________________________________________________________________| Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 1 1 2 2 1 | Basophilic Focus | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Inflammation, Acute | 2 | Necrosis | 2 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Necrosis | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 1 2 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +| Angiectasis | | Hyperplasia | 2 1 1 2 1 2 2 2 2 2 2 | Hypertrophy | 2 3 2| Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + A + +| Hyperplasia | 2 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + M + + + + + + + + + + + + M| Hyperplasia | 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| Cyst | | Pars Distalis, Angiectasis | 3 | Pars Distalis, Hyperplasia | 3 4 2 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + A + +| C-Cell, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 1 1 2 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + M + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Vagina | + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +| Hyperplasia, Histiocytic | | __________________________________________________________________________| Lymph Node | + + + + + + +| Renal, Hemorrhage | 2 | Renal, Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + + + + + M M + + + + + + + + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M + M + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrosis | 2 1 | Hematopoietic Cell Proliferation | 3 | Hemorrhage | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + I +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 3 2 4 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 2 2 | Alveolar Epithelium, Hyperplasia | 1 1 1 1 4 1 1 | __________________________________________________________________________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Thrombosis | 2 1 2 3 2 | Glands, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Lateral Wall, Hyperplasia | 2 2 2 2 2 3 2 2 2 2 2 2 2 1 2 2 3 3 2 2 2 2 2 2| Olfactory Epithelium, Atrophy | 2 2 2 2 2 2 1 2 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2| Olfactory Epithelium, Degeneration, | | Hyaline | 3 3 3 3 3 3 2 2 2 2 3 3 2 3 3 3 2 3 3 3 2 2 2| Olfactory Epithelium, Fibrosis | 2 2 1 1 2 1 1 2 | Olfactory Epithelium, Hyperplasia | 2 2 1 1 1 1 2 1 1 1 2 1 1 1 1 2 | Olfactory Epithelium, Metaplasia | 2 2 2 1 2 1 2 2 1 2 2 2 1 2 2 1 1 2 2 2| Respiratory Epithelium, Degeneration,| | Hyaline | 3 2 2 1 2 2 2 2 2 2 1 1 2 2 2 1 2 2 1 1 1| Respiratory Epithelium, Hyperplasia | 2 2 2 3 3 2 2 3 2 1 2 2 2 1 3 3 1 2 2 2 3 2| Respiratory Epithelium, Metaplasia, | | Squamous | 1 1 | __________________________________________________________________________| Trachea | + + + + + + A + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | Retina, Atrophy | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 1 1 2 3 2 2 2 2 1 2 2 2 1 2 2 2 1 1 3 1 1 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + + + + + + M + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I| 47 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | Parasite Metazoan | X X X | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 2 | 3 1.3| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 34 | Clear Cell Focus | X X X | 6 | Degeneration, Cystic | | 1 2.0| Degeneration, Fatty | 2 3 3 2 | 10 2.4| Eosinophilic Focus | X X X | 4 | Hepatodiaphragmatic Nodule | X X | 6 | Inflammation, Granulomatous | | 1 2.0| Mixed Cell Focus | X X X X X X X X| 9 | Bile Duct, Hyperplasia | 1 2 | 6 1.8| Centrilobular, Necrosis | 1 2 | 8 1.3| __________________________________________________________________________|____________| Mesentery | + + + + + | 11 | Fat, Necrosis | 3 3 1 2 1 | 11 2.0| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Hyperplasia, Squamous | 4 | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Atrophy | 2 3 1 1 | 11 1.6| Basophilic Focus | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Squamous | | 1 2.0| Inflammation, Acute | | 1 2.0| Necrosis | 2 3 | 5 2.6| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | | 1 1.0| Necrosis | 1 3 2 | 3 2.0| __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy | 1 1 1 1 1 2 2 2 2 1 1 2 2 1| 23 1.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 2 | 1 2.0| Hyperplasia | 1 2 2 2 2 2 2 2 3 2 | 21 1.9| Hypertrophy | 2 2 2 | 6 2.2| Vacuolization Cytoplasmic | 2 | 3 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 1 1 2 2 3 3 | 10 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + +| 44 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Cyst | 3 | 1 3.0| Pars Distalis, Angiectasis | 4 3 | 3 3.3| Pars Distalis, Hyperplasia | 2 | 7 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | C-Cell, Hyperplasia | 2 1 2 3 1 1 2 1 1 1 2 1 1 1 2 1 1 1| 35 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + +| 46 | Hyperplasia | 3 2 | 2 2.5| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 2 3 3 | 6 2.7| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Vagina | + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Histiocytic | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Hemorrhage | | 1 2.0| Renal, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + M + + + + + + + + + M + + + M + + + M| 40 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + M + + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + M + + + + + +| 45 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Accessory Spleen | | 2 | Fibrosis | 2 | 3 1.7| Hematopoietic Cell Proliferation | 3 | 2 3.0| Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + M + + + + + + + M + + + + + + + + + + + M + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Galactocele | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperostosis | 3 4 2 4 3 2 | 12 2.8| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Granulomatous | | 2 2.0| Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 1 | 13 1.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Suppurative | 2 1 2 1 1 | 5 1.4| Thrombosis | 3 | 6 2.2| Glands, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 24 1.0| Lateral Wall, Hyperplasia | 2 2 3 2 2 3 2 2 2 2 2 1 2 1 3 2 3 2 2 2 2 1 2 2| 48 2.1| Olfactory Epithelium, Atrophy | 2 1 2 1 2 1 2 2 2 2 2 1 1 1 2 2 1 2 1 1 2| 44 1.7| Olfactory Epithelium, Degeneration, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hyaline | 3 3 3 3 4 3 3 3 3 3 3 3 3 2 3 4 2 3 2 3 3 3 2 2| 47 2.7| Olfactory Epithelium, Fibrosis | 1 1 1 1 1 1 1 1 | 16 1.3| Olfactory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.2| Olfactory Epithelium, Metaplasia | 1 2 1 1 1 1 1 2 2 1 1 1 1 2 2 1 1| 37 1.5| Respiratory Epithelium, Degeneration,| | | Hyaline | 2 2 2 1 2 2 2 3 1 3 2 2 2 1 2 2 2 2 2 4 3 3 2 2| 45 1.9| Respiratory Epithelium, Hyperplasia | 2 2 3 2 1 1 2 2 3 2 2 3 2 3 2 2 2 2| 40 2.1| Respiratory Epithelium, Metaplasia, | | | Squamous | | 2 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 3 | 1 3.0| Retina, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy | 2 3 2 2 1 2 2 1 2 2 2 3 3 2 2 2 2 2 2 3 2 2 3 2| 47 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Transitional Epithelium, Hyperplasia | 3 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 2 1 1 | Basophilic Focus | X X X X X X X X X X X X X X| Clear Cell Focus | X X | Degeneration, Cystic | 2| Degeneration, Fatty | 3 2 2 1 3 3 4 3 | Eosinophilic Focus | | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X X X X X | Necrosis | 2 | Regeneration | | Bile Duct, Hyperplasia | 2 2 1 | Centrilobular, Necrosis | 1 1 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 3 1 2 1 | Basophilic Focus | | Metaplasia, Hepatocyte | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Necrosis | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 4 3 2 3 3 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | 1 1 1 3 3 3 | __________________________________________________________________________| Tongue | + + | Hyperplasia, Squamous | 3 | __________________________________________________________________________| Tooth | | Degeneration | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 1 1 1 2 1 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 2 2 2 2 1 1 2 2 2| Hypertrophy | 2| Necrosis | | Vacuolization Cytoplasmic | 3 2 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 3 2 2 2 3| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 2 3 3 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 1 1 1 4 4 2 1 1 2 1 1 1 2 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + M + M + + +| Hyperplasia | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 2 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + | Renal, Ectasia | 2 | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M M M + M + + + + + + + M M M M + M M + M M M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + M M + M + + + + + + + + + + + + + M + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + M M + + + + + + + + + M + + + + M + + + + + M| Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Fibrosis | 2 2 2 2 | Hematopoietic Cell Proliferation | 3 3 | Inflammation, Granulomatous | | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + M + + + + M + + + + + M| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 2 2 2 2 | Hyperplasia, Atypical | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Subcutaneous Tissue, Necrosis | 3 | Tail, Hyperkeratosis | 1 | Tail, Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 | Hyperostosis | 3 2 3 | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Inflammation, Granulomatous | 2 2 | Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 1 2 1 | Mediastinum, Inflammation, | | Granulomatous | | __________________________________________________________________________| Nose | + + + + + + + + + + A + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 2 2 1 2 1 1 3 2 2 2 2| Thrombosis | 3 | Glands, Hyperplasia | 1 3 3 1 3 3 3 2 3 1 1 1 2 4 1 3 3 2 2 3 3 1| Lateral Wall, Hyperplasia | 2 4 3 3 4 4 3 4 3 3 4 3 4 3 3 4 2 3 3 4 3 3 3 3| Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 1 1 | Olfactory Epithelium, Atrophy | 2 2 2 2 2 2 2 3 2 3 2 2 3 2 2 2 2 2 3 2 2 3 2 2| Olfactory Epithelium, Degeneration, | | Hyaline | 3 4 3 2 2 3 3 3 4 4 3 3 2 3 3 4 4 4 4 3 4 4 4 3| Olfactory Epithelium, Fibrosis | 1 2 2 2 1 2 2 2 2 2 1 1 | Olfactory Epithelium, Hyperplasia | 1 1 2 1 1 1 2 2 1 1 1 1 1 2 2 2 1 1 1 1 1| Olfactory Epithelium, Metaplasia | 2 2 2 2 2 2 2 2 2 3 2 2 2 1 2 2 2 2 3 2 2 3 2 2| Respiratory Epithelium, Degeneration,| | Hyaline | 2 2 | Respiratory Epithelium, Hyperplasia | 2 3 4 3 3 4 2 4 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3| Respiratory Epithelium, Metaplasia, | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Squamous | 1 1 2 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy | 3 4 4 2 3 3 4 2 3 3 2 3 3 1 3 2 3 3 2 2 1 3 2 3 3| Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 5 1.4| Basophilic Focus | X X X X X X X X| 22 | Clear Cell Focus | X | 3 | Degeneration, Cystic | | 1 2.0| Degeneration, Fatty | 3 1 1 1 2 3 2 3 1 | 17 2.2| Eosinophilic Focus | X | 1 | Hepatodiaphragmatic Nodule | X | 4 | Mixed Cell Focus | X X X | 8 | Necrosis | 2 | 2 2.0| Regeneration | 4 | 1 4.0| Bile Duct, Hyperplasia | 2 2 1 2 | 7 1.7| Centrilobular, Necrosis | 1 1 1 1 1 1 1 | 9 1.0| __________________________________________________________________________|____________| Mesentery | + + + | 7 | Fat, Necrosis | 2 3 | 6 2.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 1 1 2 2 1| 11 1.5| Basophilic Focus | X | 1 | Metaplasia, Hepatocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3 3 4 3 | 12 3.2| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 1 1.0| Necrosis | 3| 7 2.1| __________________________________________________________________________|____________| Tongue | + | 3 | Hyperplasia, Squamous | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | + | 1 | Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 2 1 1 1 | 19 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 1 2 2| 23 1.8| Hypertrophy | 2 | 2 2.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 3 3 2| 8 2.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 3 3 1 | 14 2.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + M + + + + M + + + + + + + +| 46 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 2 3 2 | 9 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 39 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 45 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 1 2 2 | 7 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + | 11 | Renal, Ectasia | | 1 2.0| Renal, Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M + M + + M M + + M M + + M + M M + M M +| 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + M M + +| 42 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M + M + + + + + M + M + + + M + + + +| 40 | Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | X | 1 | Fibrosis | 3 | 5 2.2| Hematopoietic Cell Proliferation | 3 4 3 | 5 3.2| Inflammation, Granulomatous | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + M + + + M + M| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 2 | 5 2.0| Hyperplasia, Atypical | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 3 | 1 3.0| Subcutaneous Tissue, Necrosis | | 1 3.0| Tail, Hyperkeratosis | | 1 1.0| Tail, Inflammation, Chronic Active | 3 2 1 3 | 5 2.4| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 1.0| Hyperostosis | 2 4 3 | 6 2.8| Inflammation, Chronic | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X| 1 | Inflammation, Granulomatous | 4| 3 2.7| Alveolar Epithelium, Hyperplasia | 1 1 2 2 | 12 1.3| Mediastinum, Inflammation, | | | Granulomatous | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Suppurative | 3 2 1 2 1 1 1 2 3 2| 23 1.7| Thrombosis | 3 4 2 3 | 5 3.0| Glands, Hyperplasia | 2 2 2 1 3 3 1 2 2 2 2 3 1 3 2 2 3 3 2 4 3 2 2 2| 46 2.2| Lateral Wall, Hyperplasia | 4 3 3 3 3 4 3 3 3 4 4 4 4 3 2 3 4 3 3 4 4 3 3 4 2| 49 3.3| Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 24 1.0| Olfactory Epithelium, Atrophy | 2 3 2 2 3 2 2 3 2 2 2 3 2 2 2 2 2 3 3 3 3 3 2 2 2| 49 2.3| Olfactory Epithelium, Degeneration, | | | Hyaline | 4 3 3 4 3 3 3 3 4 2 3 3 3 3 4 4 4 4 3 4 4 4 2 3| 48 3.3| Olfactory Epithelium, Fibrosis | 1 1 2 2 3 1 2 2 2 2 2 2 1 2 1 2 1 2 2| 31 1.7| Olfactory Epithelium, Hyperplasia | 2 2 1 2 2 1 2 2 2 1 2 2 2 2 1 2 3 2 2 1| 41 1.5| Olfactory Epithelium, Metaplasia | 2 3 2 1 3 2 3 2 2 2 3 2 2 2 2 2 3 3 3 3 3 2 2 2| 48 2.2| Respiratory Epithelium, Degeneration,| | | Hyaline | 3 1 1 3 | 6 2.0| Respiratory Epithelium, Hyperplasia | 4 4 4 3 4 4 3 3 3 4 4 4 4 3 3 2 3 3 3 3 3 3 3 4 3| 49 3.2| Respiratory Epithelium, Metaplasia, | | | Squamous | 1 1 2 1 1 | 10 1.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Nephropathy | 1 1 1 1 3 2 2 3 3 2 2 4 3 2 2 3 2 2 1 3 2 3| 47 2.4| Renal Tubule, Hyperplasia | 3| 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + A + + + I + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + A + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X | Clear Cell Focus | X X | Degeneration, Cystic | 2 2 3 2 1| Degeneration, Fatty | 4 1 1 | Eosinophilic Focus | | Regeneration | 3 | Vacuolization Cytoplasmic, Focal | 2 | Bile Duct, Hyperplasia | 3 2 2 2 1 3 1 1 4 2 1 2 3| Centrilobular, Necrosis | 2 1 1 1 1 3 1 2| __________________________________________________________________________| Mesentery | + + + + + + + +| Fat, Necrosis | 3 2 2 2 2 2 2| __________________________________________________________________________| Oral Mucosa | | Gingival, Inflammation, Chronic | | Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 2 1 1 2 1 1 2 | Basophilic Focus | X | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + M + +| Atrophy | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | Necrosis | 4 4 3 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | 2 2 2 3 2 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 3 2 1 2 3 1 2 1 3 2 2 1 2| Artery, Mineralization | | Atrium, Thrombosis | 4 2 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 | Hypertrophy | 1 | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 2 2 1 2 3 2 3 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 3 1 2 1 1 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | Inflammation, Chronic Active | 4 3 3 2 4 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Artery, Inflammation, Chronic Active | 1 | Interstitial Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Hemorrhage | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + M M + M M + + M + M + + + + + + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + M + M M + + + + + + + M + +| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M M + M + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X| Fibrosis | 2 2 2 2 2 | Hematopoietic Cell Proliferation | 3 | Hyperplasia, Focal | | Necrosis | 4 3 | __________________________________________________________________________| Thymus | + M + + + + + + + + + M + + M + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + M M M + M M + M M M + + + + M M M + M| Degeneration | 3 | Galactocele | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Tail, Hyperkeratosis | 3 | Tail, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 | Mineralization | | Alveolar Epithelium, Hyperplasia | 2 1 1 3 1 | Artery, Mediastinum, Mineralization | | Mediastinum, Inflammation, | | Suppurative | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Thrombosis | 3 2 2 2 2 1 2 | Lateral Wall, Hyperplasia | | Lateral Wall, Metaplasia, Squamous | 1 | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lateral Wall, Necrosis | | Olfactory Epithelium, Atrophy | | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 2 1| Olfactory Epithelium, Metaplasia | | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2| Infarct | | Mineralization | | Nephropathy | 3 4 2 4 3 2 2 3 2 3 1 4 4 2 4 2 3 4 2 3 1 3 3 3 3| Papilla, Necrosis | | Renal Tubule, Hyperplasia | 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Necrosis | | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + A + + + + + + + + + + + + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2 1 1 1 1 | 6 1.2| Basophilic Focus | X X X X X X X | 9 | Clear Cell Focus | X X X| 5 | Degeneration, Cystic | 2 3 1 2 2 1 2 | 12 1.9| Degeneration, Fatty | 4 1 | 5 2.2| Eosinophilic Focus | X X X X | 4 | Regeneration | | 1 3.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| Bile Duct, Hyperplasia | 2 2 3 1 1 2 2 2 2 3 2 2 1 3 1| 28 2.0| Centrilobular, Necrosis | 1 1 2 1 | 12 1.4| __________________________________________________________________________|____________| Mesentery | + + + | 11 | Fat, Necrosis | 2 2 2 | 10 2.1| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Gingival, Inflammation, Chronic | | | Active | 4 | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 3 1 1 2 2 2 1 2 1 2 | 22 1.6| Basophilic Focus | X X | 3 | Hyperplasia | 3 2 2 2 1 | 5 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | 2 | 1 2.0| Mineralization | 2 | 1 2.0| Necrosis | 1 3 2 2 | 9 2.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 4 2 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | 2 | 7 2.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + | 2 | Aorta, Mineralization | 4 1 | 2 2.5| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 3 3 2 3 3 2 2 1 3 2 2 3 3 1 3 3 1 2 2 1| 38 2.1| Artery, Mineralization | 4 2 | 2 3.0| Atrium, Thrombosis | | 3 3.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 1 2 2 2 2 2 2 2| 15 1.9| Hypertrophy | 2 3 | 3 2.0| Vacuolization Cytoplasmic | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 3 3 2 2 2 2 3 2 3 3 2 2 4 2 | 30 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 3 2 2 2 2 | 9 2.1| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 1 2.0| Pars Distalis, Hemorrhage | 4 | 1 4.0| Pars Distalis, Hyperplasia | 3 3 2 | 4 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 2 3 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 27 1.3| Follicular Cell, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 2 2 1| 7 2.0| Inflammation, Chronic Active | 2 3 3 3 | 9 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 3 | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Artery, Inflammation, Chronic Active | 2 2 | 3 1.7| Interstitial Cell, Hyperplasia | 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + | 10 | Renal, Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + + + M + + + M + + + + + + + + + +| 39 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 44 | Infiltration Cellular, Plasma Cell | 3| 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + M + + M + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | X X | 3 | Fibrosis | 2 2 2 2 2 2 2 2 1| 14 1.9| Hematopoietic Cell Proliferation | | 1 3.0| Hyperplasia, Focal | 4 | 1 4.0| Necrosis | | 2 3.5| __________________________________________________________________________|____________| Thymus | + M + + + + + M + + + + + M + + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + M + M + + + + M + + M + + + + + M M +| 30 | Degeneration | | 1 3.0| Galactocele | 2 2 3 3 | 6 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| Tail, Hyperkeratosis | | 1 3.0| Tail, Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | | 1 1.0| Mineralization | 4 | 1 4.0| Alveolar Epithelium, Hyperplasia | 1 2 1 1 3 3 1 | 12 1.7| Artery, Mediastinum, Mineralization | 3 | 1 3.0| Mediastinum, Inflammation, | | | Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 | 3 1.0| Thrombosis | 2 1 1 | 10 1.8| Lateral Wall, Hyperplasia | 1 | 1 1.0| Lateral Wall, Metaplasia, Squamous | | 1 1.0| Lateral Wall, Necrosis | 2 | 1 2.0| Olfactory Epithelium, Atrophy | 1 | 1 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 2 1 1 1 1 1 2 2 2 1 2 1 2 2 2 2 2 1 1 1 1 1| 42 1.3| Olfactory Epithelium, Metaplasia | 1 | 1 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1 | 12 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | +| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Infarct | 2 | 1 2.0| Mineralization | 3 3 | 2 3.0| Nephropathy | 4 3 2 4 3 4 4 4 4 3 3 4 2 2 3 3 3 2 4 4 2 3 3 2 2| 50 2.9| Papilla, Necrosis | 3 | 1 3.0| Renal Tubule, Hyperplasia | 3 4 4 | 5 2.8| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + M + + + + + + M + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 | Basophilic Focus | X X X X X X X| Clear Cell Focus | | Degeneration, Cystic | 3 2 2 2 2 2 2 1 | Degeneration, Fatty | 2 2 1 1 3| Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X | Necrosis | 2 | Regeneration | 4 2 2 | Bile Duct, Hyperplasia | 3 2 2 2 3 1 1 2 3 2 2 1 3 3 2 | Centrilobular, Necrosis | 2 1 2 1 2 2 1 1 1 | __________________________________________________________________________| Mesentery | + + + + + | Artery, Mineralization | 4 | Fat, Hemorrhage | | Fat, Necrosis | 3 2 2 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 3 1 1 1 2 1 1 2 3 2 2 1 | Basophilic Focus | | Hyperplasia | | Artery, Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Acute | | Mineralization | 3 | Necrosis | 4 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 4 | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Necrosis | 2 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 2 3 3 1 1 2 1 2 1 1 2 1 | Artery, Mineralization | 3 | Atrium, Thrombosis | 1 3 3 3 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | Hypertrophy | | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 3 3 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 4 4 2 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 2 3 3 3 3 | Pars Intermedia, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 4 3 2 4 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Artery, Inflammation, Chronic Active | 2 | Interstitial Cell, Hyperplasia | 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 3 | __________________________________________________________________________| Lymph Node | + + + +| __________________________________________________________________________| Lymph Node, Bronchial | + M + + M M M + M + + + M + + + + M + + M + M M M| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + + + M + + + + M + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + M + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 1 3 2 2 | Hematopoietic Cell Proliferation | | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + M M M + + M M + + +| Cyst | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M M M + + + M M + M M M M + + + + M M + M M| Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation, Acute | 4 | Inflammation, Chronic Active | 3 4 | Necrosis | 4 | Subcutaneous Tissue, Edema | 3 | Tail, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 4 1 | Hyperostosis | 1 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Inflammation, Granulomatous | 2 | Inflammation, Suppurative | | Metaplasia, Squamous | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Mineralization | 3 | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | 1 1 1 1 | Artery, Mediastinum, Mineralization | 4 | Perivascular, Infiltration Cellular, | | Mononuclear Cell | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 | Thrombosis | 3 1 3 3 3 4 3 | Lateral Wall, Hyperplasia | 2 2 2 2 1 1 1 2 1 1 1 1 1 1 2 2 1 2 2 2 2 1 1 1 1| Lateral Wall, Metaplasia, Squamous | 1 | Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 1 2 2 2 1 1 1 1 2 1 1 1 1 1 2 2 1 1 1 2 1 1| Olfactory Epithelium, Fibrosis | 1 | Olfactory Epithelium, Hyperplasia | 1 | Olfactory Epithelium, Metaplasia | 2 1 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 1 1 1 | Respiratory Epithelium, Hyperplasia | 2 2 2 2 1 3 2 1 2 2 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Cataract | 4 | Inflammation, Chronic Active | 4 4 | Retina, Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 | Infarct | 2 2 | Mineralization | 4 | Nephropathy | 2 4 3 2 3 3 3 4 4 2 4 2 3 2 3 3 4 3 4 2 3 3 4 4 | Renal Tubule, Hyperplasia | 1 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 1.5| Basophilic Focus | X X X X X| 12 | Clear Cell Focus | X | 1 | Degeneration, Cystic | 2 1 2 3 2 4 2 2 1 1 | 18 2.0| Degeneration, Fatty | 1 1 4 1 | 9 1.8| Eosinophilic Focus | | 2 | Hepatodiaphragmatic Nodule | | 1 | Mixed Cell Focus | | 1 | Necrosis | 3 | 2 2.5| Regeneration | | 3 2.7| Bile Duct, Hyperplasia | 1 1 3 2 1 2 4 2 2 2 3 3 3 3 2 2| 31 2.2| Centrilobular, Necrosis | 1 1 1 1 2 1 1 1 | 17 1.3| __________________________________________________________________________|____________| Mesentery | + + + + + + + + | 13 | Artery, Mineralization | 3 | 2 3.5| Fat, Hemorrhage | 2 2 | 2 2.0| Fat, Necrosis | 2 3 2 | 6 2.3| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 2 1 3 2 1 1| 22 1.8| Basophilic Focus | X| 1 | Hyperplasia | 2 2 | 2 2.0| Artery, Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Acute | 2 | 1 2.0| Mineralization | 2 | 2 2.5| Necrosis | 3 3 4 | 6 3.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 3 | 2 3.5| Necrosis | 1 3 | 3 2.0| __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Aorta, Mineralization | 3 | 2 3.5| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 1 2 2 2 2 3 2 2 3 1 2 1 2| 32 1.7| Artery, Mineralization | 4 | 2 3.5| Atrium, Thrombosis | | 6 2.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 2 2 2 2 2 2| 19 1.9| Hypertrophy | 2 2 2 | 3 2.0| Vacuolization Cytoplasmic | 3 | 3 2.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 3 3 2 2 4 2 1 3| 17 2.4| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + M + M M + + + +| 45 | Hyperplasia | 2 | 5 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 2 2 | 8 2.6| Pars Intermedia, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + I + + + + + + +| 49 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 33 1.1| Follicular Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 | 3 1.7| Inflammation, Chronic Active | 3 3 3 3 | 8 3.1| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Artery, Inflammation, Chronic Active | | 1 2.0| Interstitial Cell, Hyperplasia | 1 1 2 | 6 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + M M + + M M + M + + M M + M + + + M M| 28 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + M M + + + + + + + + + + + + M +| 42 | Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 4 2 4 2 | 13 2.3| Hematopoietic Cell Proliferation | 2 2 | 2 2.0| Necrosis | 4 | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + M + + M + + + + M + + + + + + + + M + + +| 40 | Cyst | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M M + + + + M M M + M + M M + + + + M + + + + M| 25 | Galactocele | 2 | 2 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 2 | Inflammation, Acute | 2 | 2 3.0| Inflammation, Chronic Active | | 2 3.5| Necrosis | | 1 4.0| Subcutaneous Tissue, Edema | | 1 3.0| Tail, Inflammation, Chronic Active | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Fibrous Osteodystrophy | 1 3 | 5 2.2| Hyperostosis | 3 3 2 | 5 2.4| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 3 | 2 2.5| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X | 1 | Inflammation, Granulomatous | | 1 2.0| Inflammation, Suppurative | 4 | 1 4.0| Metaplasia, Squamous | 2 | 1 2.0| Mineralization | 3 | 2 3.0| Thrombosis | | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 1 1 | 7 1.0| Artery, Mediastinum, Mineralization | 3 | 2 3.5| Perivascular, Infiltration Cellular, | | | Mononuclear Cell | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 1 2 1 | 6 1.5| Thrombosis | 1 2 4 3 3 2 4 1 | 15 2.7| Lateral Wall, Hyperplasia | 1 1 2 1 1 2 2 1 2 3 1 1 2 1 2 1 1 2 2 2 1 3 1 1| 49 1.5| Lateral Wall, Metaplasia, Squamous | | 1 1.0| Olfactory Epithelium, Atrophy | 1 2 1 1 1 1 | 12 1.1| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 1 2 1 2 1 2 1 1| 48 1.5| Olfactory Epithelium, Fibrosis | | 1 1.0| Olfactory Epithelium, Hyperplasia | | 1 1.0| Olfactory Epithelium, Metaplasia | 2 1 1 1 | 8 1.3| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1| 14 1.0| Respiratory Epithelium, Hyperplasia | 1 1 1 2 2 1 2 2 2 2 2 2 2 3 | 26 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Cataract | | 1 4.0| Inflammation, Chronic Active | | 2 4.0| Retina, Atrophy | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 3 2.3| Infarct | | 2 2.0| Mineralization | 2 | 2 3.0| Nephropathy | 3 1 2 3 4 2 2 3 2 2 3 3 2 2 2 3 4 4 3 3 2 4 3 3 3| 49 2.9| Renal Tubule, Hyperplasia | 3 2 | 5 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 2 | Basophilic Focus | X X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Cyst | | Degeneration, Cystic | 1 3 3 1 2 3 2 | Degeneration, Fatty | | Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X | Regeneration | 3 | Tension Lipidosis | X | Bile Duct, Hyperplasia | 2 1 1 2 3 1 1 2 2 2 3 2 3 1 2 3 2 3 2| Centrilobular, Necrosis | 3 2 2 1 1 2 2| __________________________________________________________________________| Mesentery | + + + + + | Pigmentation | 4 | Fat, Hemorrhage | 2 | Fat, Necrosis | 3 2 3 | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Hyperplasia | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 2 2 1 2 1 2 3 1 3 3 | Basophilic Focus | X X | Artery, Mineralization | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Necrosis | 4 4 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 4 | Necrosis | 2 3 2 2 | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + | Aorta, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 1 3 2 2 3 4 3 3 3 2 2 2 1 2 1 2 2 1 | Artery, Mineralization | 4 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 1 3 2 2 2 2 2 2| Hypertrophy | | Necrosis | 3 3 | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 3 3 1 3 2 3 3 2 2 2 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 4 3 2 2 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| Pars Distalis, Hyperplasia | 4 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 3 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Artery, Inflammation, Chronic Active | 1 3 2 | Interstitial Cell, Hyperplasia | 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + +| Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M M + + + + + + M + + M M + M M + M + M + + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Fibrosis | 2 2 3 3 2| Hematopoietic Cell Proliferation | | Hyperplasia, Focal | 4 | Necrosis | 2 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + M + + + M M + + + + + + M + + + + + M +| Degeneration | | Galactocele | 2 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 3 | Inflammation, Granulomatous | 4 | Tail, Inflammation, Chronic Active | 3 3 3 3 3 | Tail, Subcutaneous Tissue, Thrombosis| 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 2 2 4 2 | Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mineralization | 4 | Alveolar Epithelium, Hyperplasia | 1 3 1 | Artery, Mediastinum, Mineralization | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 1 2 2 2 1 2 2 2 1 | Thrombosis | 3 3 1 4 2 4| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Glands, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1| Lateral Wall, Hyperplasia | 2 3 3 2 2 2 2 2 3 2 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2| Lateral Wall, Metaplasia, Squamous | 1 1 | Nasopharyngeal Duct, Inflammation, | | Acute | | Olfactory Epithelium, Atrophy | 1 1 2 1 2 2 2 1 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2| Olfactory Epithelium, Degeneration, | | Hyaline | 3 3 2 3 2 2 3 3 3 2 2 2 3 3 3 3 3 2 2 3 3 3 2 2 3| Olfactory Epithelium, Fibrosis | 1 1 1 1 2 1 1 1 1 1 | Olfactory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Olfactory Epithelium, Metaplasia | 1 1 1 1 2 2 1 1 2 2 2 2 2 1 1 1 2 1 2 1 1| Respiratory Epithelium, Degeneration,| | Hyaline | 1 2 2 2 1 2 2 2 2 1 2 1 2 1 2 2 2 2 2 2 1 1 1 1 1| Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 3 2 3 2 2 2 2 3 2 3 3 3 3 3 3 2 2 2 3 2| Respiratory Epithelium, Metaplasia, | | Squamous | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 2 2 | Mineralization | 4 | Nephropathy | 3 3 3 2 4 4 4 4 4 4 2 4 4 4 2 3 4 4 4 2 2 4 4 2 2| STROMAL HYPERPLASIA | 3 | Renal Tubule, Hyperplasia | 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Mineralization | 3 | 1 3.0| Parasite Metazoan | X X X | 6 | __________________________________________________________________________|____________| Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + A + + A + + + + + + + + + + + A + + A + +| 44 | Parasite Metazoan | X X | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + A + + A + + + + + + + + + + + A + + A + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + A + + A + + + + + + + + + + + A + + A + +| 43 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 3 2.3| Basophilic Focus | X X X X X X X X X X X| 27 | Clear Cell Focus | X X| 4 | Cyst | 2 2 | 2 2.0| Degeneration, Cystic | 1 3 2 2 3 | 12 2.2| Degeneration, Fatty | 2 1 2| 3 1.7| Eosinophilic Focus | | 3 | Hepatodiaphragmatic Nodule | X | 4 | Mixed Cell Focus | X | 2 | Regeneration | 4 | 2 3.5| Tension Lipidosis | | 1 | Bile Duct, Hyperplasia | 2 3 1 2 2 2 3 3 2 3 1 | 30 2.1| Centrilobular, Necrosis | 2 1 1 1 1 1 1 1 | 15 1.5| __________________________________________________________________________|____________| Mesentery | + + + +| 9 | Pigmentation | | 1 4.0| Fat, Hemorrhage | | 1 2.0| Fat, Necrosis | 2 2 2 2| 7 2.3| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 1 1 2 1 3 2 1 2 2 3| 23 2.0| Basophilic Focus | | 2 | Artery, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | 3 | 2 3.0| Necrosis | 3 3 2 2 2 2 2| 10 2.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 4 | 3 3.7| Necrosis | | 4 2.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 3 | Aorta, Mineralization | 4 | 2 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 2 2 2 2 1 1 1 1 2 1 1 2 2 3 2 2| 40 1.9| Artery, Mineralization | 4 | 2 4.0| Atrium, Thrombosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 1 3 2 2 2 2| 20 2.1| Hypertrophy | 2 | 1 2.0| Necrosis | | 2 3.0| Vacuolization Cytoplasmic | 1 3 | 4 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 2 2 2 2 2 4 2 2| 24 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 3 3 2| 12 2.4| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Pars Distalis, Hyperplasia | 2 | 3 2.7| __________________________________________________________________________|____________| Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1| 30 1.1| Follicular Cell, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05201-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:16:25 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 5 2.2| Inflammation, Chronic Active | 3 1 | 3 2.3| __________________________________________________________________________|____________| Seminal Vesicle | + + A + A + + + + + + + + + + + + + + A + + M + +| 46 | Mineralization | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 3 | 3 3.0| Artery, Inflammation, Chronic Active | 3 | 4 2.3| Interstitial Cel