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TDMS Study 05201-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 09/09/97

EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 16:22:52
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Kidney
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 09/09/97     
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 16:22:52     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000  



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 FURFURYL ALCOHOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Kidney, Renal Tubule (Step Section)    Carcinoma and Adenoma
Kidney, Renal Tubule (Step and Original Sections)
                                       Adenoma
                                       Carcinoma
                                       Carcinoma and Adenoma
Kidney: Renal Tubule                   Adenoma
                                       Carcinoma
                                       Carcinoma or Adenoma
===============================================================
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Carcinoma and Adenoma                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/49 (10%)   3/49 (6%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     6.9%         11.7%        7.7%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/34 (6%)    5/36 (14%)   3/30 (10%)   2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     697          733 (T)      733 (T)      733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.227N     P=0.384      P=0.599      P=0.446N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.237N     P=0.350      P=0.614      P=0.474N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.251N     P=0.348      P=0.628      P=0.485N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.222N     P=0.353      P=0.598      P=0.462N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.218N     P=0.360      P=0.595      P=0.456N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.271N     P=0.346      P=0.651      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Hyperplasia and Adenoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/49 (10%)   3/49 (6%)    3/50 (6%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     6.9%         11.7%        7.7%         6.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/34 (6%)    5/36 (14%)   3/30 (10%)   3/38 (8%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     697          733 (T)      733 (T)      733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.389N     P=0.384      P=0.599      P=0.607N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.407N     P=0.350      P=0.614      P=0.636N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.425N     P=0.348      P=0.628      P=0.647N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.388N     P=0.353      P=0.598      P=0.624N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.376N     P=0.360      P=0.595      P=0.617N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.450N     P=0.346      P=0.651      P=0.661N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step Section)                                                                                              |
|     Hyperplasia, Carcinoma or Adenoma                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/49 (10%)   3/49 (6%)    4/50 (8%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     6.9%         11.7%        7.7%         8.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/34 (6%)    5/36 (14%)   3/30 (10%)   4/38 (11%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     697          733 (T)      733 (T)      733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.561N     P=0.384      P=0.599      P=0.563     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.585N     P=0.350      P=0.614      P=0.531     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.596      P=0.348      P=0.628      P=0.518     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.565N     P=0.353      P=0.598      P=0.545     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.547N     P=0.360      P=0.595      P=0.557     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.569      P=0.346      P=0.651      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         6.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    3/38 (8%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.013 *    (e)          (e)          P=0.141     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.009 **   (e)          (e)          P=0.130     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.009 **   (e)          (e)          P=0.125     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.010 *    (e)          (e)          P=0.135     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.141     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.009 **   (e)          (e)          P=0.121     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Carcinoma and Adenoma                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    5/50 (10%)  |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         10.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    5/38 (13%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.043 *   |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   (e)          (e)          P=0.036 *   |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.034 *   |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   (e)          (e)          P=0.038 *   |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.043 *   |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          (e)          P=0.028 *   |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    8/49 (16%)   3/49 (6%)    5/50 (10%)  |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     9.3%         18.7%        7.7%         10.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/34 (9%)    8/36 (22%)   3/30 (10%)   4/38 (11%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     697          733 (T)      733 (T)      646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.430N     P=0.202      P=0.572N     P=0.568     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.447N     P=0.170      P=0.557N     P=0.540     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.471N     P=0.169      P=0.540N     P=0.523     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.418N     P=0.171      P=0.574N     P=0.559     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.421N     P=0.179      P=0.582N     P=0.545     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.507N     P=0.168      P=0.511N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Hyperplasia and Adenoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    8/49 (16%)   3/49 (6%)    6/50 (12%)  |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     9.3%         18.7%        7.7%         13.0%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/34 (9%)    8/36 (22%)   3/30 (10%)   5/38 (13%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     697          733 (T)      733 (T)      646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.577N     P=0.202      P=0.572N     P=0.442     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.573      P=0.170      P=0.557N     P=0.410     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.548      P=0.169      P=0.540N     P=0.393     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.571N     P=0.171      P=0.574N     P=0.430     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.568N     P=0.179      P=0.582N     P=0.417     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.512      P=0.168      P=0.511N     P=0.370     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney, Renal Tubule (Step and Original Sections)                                                                                |
|     Hyperplasia, Carcinoma or Adenoma                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    8/49 (16%)   3/49 (6%)    8/50 (16%)  |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     9.3%         18.7%        7.7%         17.4%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/34 (9%)    8/36 (22%)   3/30 (10%)   7/38 (18%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     697          733 (T)      733 (T)      646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.312      P=0.202      P=0.572N     P=0.238     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.287      P=0.170      P=0.557N     P=0.209     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.266      P=0.169      P=0.540N     P=0.195     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.314      P=0.171      P=0.574N     P=0.225     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.322      P=0.179      P=0.582N     P=0.218     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.238      P=0.168      P=0.511N     P=0.178     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    4/50 (8%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         8.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    4/38 (11%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.003 **   (e)          (e)          P=0.078     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.002 **   (e)          (e)          P=0.068     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.065     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.002 **   (e)          (e)          P=0.072     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.078     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.002 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         7.0%         0.0%         6.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.358      P=0.325      P=0.525N     P=0.343     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.346      P=0.303      P=0.520N     P=0.330     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.332      P=0.300      P=0.514N     P=0.319     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.363      P=0.305      P=0.526N     P=0.342     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.355      P=0.325      (e)          P=0.320     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.314      P=0.301      P=0.505N     P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/09/97                           EXPERIMENT: 05201 TEST: 06                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia and Adenoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         7.0%         0.0%         6.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.358      P=0.325      P=0.525N     P=0.343     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.346      P=0.303      P=0.520N     P=0.330     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.332      P=0.300      P=0.514N     P=0.319     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.363      P=0.305      P=0.526N     P=0.342     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.355      P=0.325      (e)          P=0.320     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.314      P=0.301      P=0.505N     P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia, Carcinoma or Adenoma                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/49 (0%)    5/50 (10%)  |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         7.0%         0.0%         10.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    0/30 (0%)    4/38 (11%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.080      P=0.325      P=0.525N     P=0.130     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.068      P=0.303      P=0.520N     P=0.117     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.063      P=0.300      P=0.514N     P=0.111     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.075      P=0.305      P=0.526N     P=0.126     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.080      P=0.325      (e)          P=0.118     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.058      P=0.301      P=0.505N     P=0.102     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).