Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/12047

TDMS Study 05201-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 03/25/97       
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 21:43:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           CHRONIC STUDY                                                            
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 03/25/97      
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 21:43:46      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C      
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000   
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      385   465   484   497   537   547   567   567   597   651                 |
 |      661   687   692   697   712   721                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      270   287   433   497   574   577   582   590   598   601                 |
 |      632   665   693   715                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 8.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      287   317   400   455   471   471   488   497   502   532                 |
 |      548   576   582   630   651   665   665   666   669   712                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 32.0 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      382   413   582   582   590   637   646   707   707   709                 |
 |      716   724                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  98.0  94.0  90.0  82.0  78.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0 PPM    |   100.0 100.0  98.0  96.0  96.0  94.0  92.0  80.0  76.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 |8.0 PPM    |   100.0 100.0 100.0  96.0  94.0  88.0  80.0  74.0  66.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |32.0 PPM   |   100.0 100.0 100.0 100.0  96.0  96.0  96.0  90.0  86.0  76.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      2.0 PPM      8.0 PPM      32.0 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%        72.0%        60.0%        76.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.351N     P=0.838N     P=0.410      P=0.431N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       591.7        551.0        539.2        616.3    |
 |NATURAL DEATHS (C)      |       (25.4)       (36.4)       (26.8)       (33.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       687.8        682.0        655.5        705.0    |
 |(STANDARD ERROR)        |       (12.3)       (15.3)       (17.2)       (10.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      352   448   547   547   566   573   595   596   604   609                 |
 |      651   651   689   693   712   715                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 15     CENSORED DEATHS 1    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      261   441   448   457   497   525   600   601   646   649                 |
 |      684   687   721   721   730                                               |
 |  CENSORED DEATHS                                                               |
 |      681                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 8.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 1    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      411   413   469   582   604   617   621   632   637   637                 |
 |      665   665   666   684   693   693   698                                   |
 |  CENSORED DEATHS                                                               |
 |      639                                                                       |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 32.0 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      574   579   582   600   609   663   665   689   693   713                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  96.0  96.0  82.0  76.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0 PPM    |   100.0 100.0  98.0  98.0  98.0  91.8  87.8  83.7  79.6  69.1      |
 |           |                                                                    |
 |           |                                                                    |
 |8.0 PPM    |   100.0 100.0 100.0 100.0  96.0  94.0  94.0  90.0  75.9  65.6      |
 |           |                                                                    |
 |           |                                                                    |
 |32.0 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  92.0  86.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      2.0 PPM      8.0 PPM      32.0 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%        69.1%        65.6%        80.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.145N     P=1.000N     P=1.000      P=0.212N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       596.8        577.9        611.0        636.7    |
 |NATURAL DEATHS (C)      |       (24.1)       (35.0)       (22.5)       (16.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       690.1        685.1        690.3        714.5    |
 |(STANDARD ERROR)        |       (11.9)       (14.7)       (11.2)       ( 6.4)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          FURFURYL ALCOHOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2.0 PPM          = 2
                                                        8.0 PPM          = 3
                                                        32.0 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                          2 3               1
      |
      |                                            2 2     3         1   4        1
      |                                              2     3            34  2     1  1              4
   95 +
      |                                                                 3   2   3    11
      |                                                                         3  3  1      1    2 4 4
      |
P  90 +                                                                                      1 1  22  4     4
E     |
R     |                                                                            3 3         1 1 22       4 4
C     |                                                                              33             2 2       4        4
E  85 +
N     |                                                                               33         1    21
T     |                                                                                3    3          1      1        44
      |
S  80 +                                                                                     3  3       2    2 1  1      44
U     |
R     |                                                                                        3   3        2    1   1   44
V     |                                                                                            33            2   2    4 4
I  75 +
V     |                                                                                             3      3         11  2
A     |                                                                                                    3  3       1 12  2
L     |
   70 +                                                                                                       3  3      11
      |
      |                                                                                                                  1  1
      |                                                                                                          33
   65 +
      |
      |                                                                                                           3     3
      |
   60 +                                                                                                                 3   3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.
                                                          FURFURYL ALCOHOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2.0 PPM          = 2
                                                        8.0 PPM          = 3
                                                        32.0 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                         2             1        3                        4
      |
      |                                           2             1            21                   44
      |                                                                  3   21   3            1   44
   95 +
      |                                                                       2  23                 3  4
P     |                                                                                        1 1  3  43
E     |                                                                          2    2
R  90 +                                                                               2    2     11     3 3      4
C     |
E     |                                                                                    2      1   12
N     |                                                                                               11  3 3    4   4
T  85 +
      |                                                                                                11     2
S     |                                                                                                              4  4
U     |
R  80 +                                                                                                 1   3 1  3  2   4   4
V     |
I     |                                                                                                             22
V     |                                                                                                       1  33  1
A  75 +                                                                                                              2   2
L     |                                                                                                           3 3
      |                                                                                                              1  1
      |                                                                                                             33   2  2
   70 +                                                                                                                 11
      |                                                                                                                     2
      |                                                                                                              33  1  1
      |                                                                                                               3     3
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.