TDMS Study 05203-08 Pathology Tables
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
RATS, FINAL#1; CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 88-72-2
Lock Date: 12/10/98
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 004 625 PPM
Include 006 1250 PPM
Include 008 2000 PPM
Include 001 0 PPM
Include 003 625 PPM
Include 005 1250 PPM
Include 007 2000 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Moribund Sacrifice 10 11 19 22
Natural Death 3 2 2 5
Survivors
Terminal Sacrifice 45 46 39 33
Moribund Sacrifice 1 1
Natural Death 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (58) (59) (60) (59)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Large, Rectum (60) (60) (60) (58)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (57) (59) (59) (58)
Liver (60) (59) (60) (60)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 5 (8%)
Hepatocellular Adenoma, Multiple 1 (2%)
Sarcoma 1 (2%)
Mesentery (9) (1) (3) (3)
Lipoma 2 (67%)
Pancreas (60) (59) (60) (60)
Acinus, Adenoma 1 (2%) 1 (2%)
Salivary Glands (60) (60) (60) (60)
Stomach, Forestomach (59) (59) (60) (60)
Squamous Cell Papilloma 1 (2%)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (59)
Adenoma 2 (3%) 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (60) (60) (60) (58)
Pheochromocytoma Benign 2 (3%) 1 (2%)
Islets, Pancreatic (60) (59) (60) (60)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (59) (60) (60) (60)
Pars Distalis, Adenoma 19 (32%) 30 (50%) 26 (43%) 20 (33%)
Pars Distalis, Adenoma, Multiple 2 (3%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (60) (60)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 9 (15%) 5 (8%) 2 (3%) 5 (8%)
C-Cell, Carcinoma 1 (2%) 3 (5%) 3 (5%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (57) (54) (53)
Adenoma 12 (20%) 8 (14%) 3 (6%) 3 (6%)
Carcinoma 2 (3%) 4 (7%) 3 (6%)
Bilateral, Adenoma 1 (2%)
Ovary (60) (59) (60) (60)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Uterus (60) (59) (60) (60)
Hemangioma 1 (2%)
Page 3
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Polyp Stromal 11 (18%) 7 (12%) 15 (25%) 16 (27%)
Sarcoma Stromal 1 (2%) 1 (2%)
Vagina (2) (1) (3) (6)
Fibroma 1 (33%)
Granular Cell Tumor Benign 1 (17%)
Hemangioma 1 (17%)
Leiomyoma 1 (50%)
Leiomyosarcoma 1 (17%)
Squamous Cell Papilloma 1 (33%) 1 (17%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (8) (4) (4) (4)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (25%)
Lymph Node, Mandibular (60) (60) (59) (59)
Lymph Node, Mesenteric (59) (58) (59) (59)
Spleen (60) (59) (60) (59)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Thymus (57) (55) (58) (58)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (59) (60)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 17 (28%) 12 (20%) 13 (22%) 14 (23%)
Fibroadenoma, Multiple 6 (10%) 35 (58%) 39 (66%) 42 (70%)
Skin (59) (60) (60) (60)
Basal Cell Adenoma 1 (2%)
Pinna, Melanoma Malignant 1 (2%)
Pinna, Neural Crest Tumor 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (5%) 3 (5%) 18 (30%) 19 (32%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 4 (7%) 2 (3%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Neural Crest Tumor 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (1) (1)
Lipoma 1 (100%)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 3 (5%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Sarcoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1) (3)
Adenoma 1 (50%) 1 (33%)
Carcinoma 1 (50%) 1 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (60)
Urinary Bladder (60) (59) (60) (60)
Papilloma 1 (2%) 1 (2%)
Squamous Cell Papilloma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 21 (35%) 6 (10%) 4 (7%) 5 (8%)
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(60) *(60) *(60) *(60)
Lymphoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 54 58 60 60
Total Primary Neoplasms 113 131 147 165
Total Animals with Benign Neoplasms 47 57 59 59
Total Benign Neoplasms 88 112 126 143
Total Animals with Malignant Neoplasms 24 16 18 20
Total Malignant Neoplasms 25 19 20 21
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 60 60 60
Early Deaths
Moribund Sacrifice 18 35 48 53
Natural Death 3 7 6 7
Accidently Killed 3
Survivors
Terminal Sacrifice 38 18 3
Natural Death 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (59) (60) (60)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Large, Cecum (60) (60) (60) (58)
Leiomyosarcoma 1 (2%)
Intestine Small, Jejunum (59) (60) (58) (53)
Intestine Small, Ileum (58) (58) (58) (58)
Liver (60) (60) (60) (60)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 2 (3%) 2 (3%) 3 (5%) 7 (12%)
Hepatocellular Adenoma, Multiple 1 (2%)
Hepatocholangiocarcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (16) (6) (5) (4)
Fibroma 1 (20%)
Fibrosarcoma 1 (17%)
Lipoma 1 (17%)
Oral Mucosa (1) (1)
Hemangioma 1 (100%)
Pancreas (60) (60) (60) (60)
Acinus, Adenoma 1 (2%)
Islets, Pancreatic, Adenoma 1 (2%)
Salivary Glands (60) (60) (59) (60)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Page 8
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Forestomach (59) (60) (60) (60)
Stomach, Glandular (59) (60) (60) (60)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 1 (2%)
Adrenal Medulla (60) (60) (60) (59)
Neuroblastoma 1 (2%)
Pheochromocytoma Malignant 2 (3%)
Pheochromocytoma Benign 1 (2%) 4 (7%) 6 (10%) 2 (3%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (60) (60) (60)
Adenoma 2 (3%)
Carcinoma 2 (3%)
Parathyroid Gland (58) (55) (59) (58)
Adenoma 1 (2%)
Pituitary Gland (59) (60) (58) (59)
Pars Distalis, Adenoma 11 (19%) 9 (15%) 3 (5%) 9 (15%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (59) (60) (60) (60)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Sarcoma, Metastatic, Salivary Glands 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 9 (15%) 6 (10%) 1 (2%)
C-Cell, Carcinoma 4 (7%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3) (21) (33) (46)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (60) (59) (58) (56)
Adenoma 2 (3%) 3 (5%) 2 (3%) 1 (2%)
Carcinoma 2 (3%) 2 (3%) 1 (2%)
Prostate (60) (59) (60) (60)
Ventral, Adenoma 2 (3%)
Testes (60) (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 43 (72%) 34 (57%) 32 (53%) 17 (28%)
Interstitial Cell, Adenoma 12 (20%) 19 (32%) 19 (32%) 29 (48%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Histiocytic Sarcoma 1 (2%)
Lymph Node (16) (14) (4) (9)
Lymph Node, Mandibular (58) (59) (58) (59)
Histiocytic Sarcoma 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Lymph Node, Mesenteric (60) (60) (59) (58)
Spleen (60) (60) (60) (60)
Fibrosarcoma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (56) (54) (55) (55)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (47) (46) (43)
Fibroadenoma 7 (15%) 9 (20%) 2 (5%)
Fibroadenoma, Multiple 1 (2%)
Hemangioma 1 (2%)
Skin (60) (60) (60) (60)
Basal Cell Adenoma 2 (3%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 5 (8%) 3 (5%) 1 (2%)
Page 10
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibroma 4 (7%) 21 (35%) 13 (22%) 24 (40%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%) 25 (42%) 39 (65%) 35 (58%)
Subcutaneous Tissue, Fibrosarcoma 7 (12%) 13 (22%) 15 (25%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 4 (7%) 5 (8%)
Subcutaneous Tissue, Hemangioma 2 (3%)
Subcutaneous Tissue, Hemangiopericytoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 4 (7%) 12 (20%) 13 (22%)
Subcutaneous Tissue, Lipoma, Multiple 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (1) (5) (3)
Rhabdomyosarcoma 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Granular Cell Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Cranial Nerve, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 5 (8%) 1 (2%) 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Nose (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2) (1)
Schwannoma Malignant, Metastatic, Brain 1 (50%)
Harderian Gland (1) (1)
Schwannoma Malignant, Metastatic, Brain 1 (100%)
Zymbal's Gland (2) (2)
Carcinoma 2 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Urinary Bladder (60) (60) (60) (59)
Hemangioma 1 (2%)
Papilloma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Transitional Epithelium, Papilloma 2 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%) 2 (3%)
Leukemia Mononuclear 30 (50%) 21 (35%) 3 (5%) 3 (5%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 2 (3%) 20 (33%) 29 (48%) 44 (73%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:26:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 60 57 60
Total Primary Neoplasms 144 221 202 224
Total Animals with Benign Neoplasms 60 58 55 59
Total Benign Neoplasms 102 154 147 148
Total Animals with Malignant Neoplasms 37 47 42 51
Total Malignant Neoplasms 42 67 55 76
Total Animals with Metastatic Neoplasms 4 3 1
Total Metastatic Neoplasm 7 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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