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TDMS Study 05203-08 Pathology Tables

NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00
Route: DOSED FEED                                                                                                 Time: 09:26:43

                                                   RATS, FINAL#1; CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:  88-72-2

       Lock Date:  12/10/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 PPM
                               Include 004    625 PPM
                               Include 006    1250 PPM
                               Include 008    2000 PPM
                               Include 001    0 PPM
                               Include 003    625 PPM
                               Include 005    1250 PPM
                               Include 007    2000 PPM


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           11           19           22                                     
    Natural Death                                      3            2            2            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           46           39           33                                     
    Moribund Sacrifice                                 1            1                                                               
    Natural Death                                      1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (58)         (59)         (60)         (59)                                   
      Polyp Adenomatous                                             1 (2%)                    1 (2%)                                
   Intestine Large, Rectum                            (60)         (60)         (60)         (58)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Ileum                             (57)         (59)         (59)         (58)                                   
   Liver                                              (60)         (59)         (60)         (60)                                   
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)                    1 (2%)       5 (8%)                                
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
      Sarcoma                                                       1 (2%)                                                          
   Mesentery                                          (9)          (1)          (3)          (3)                                    
      Lipoma                                                                                  2 (67%)                               
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Acinus, Adenoma                                               1 (2%)       1 (2%)                                             
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (59)         (59)         (60)         (60)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Tongue                                                                       (1)          (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma Malignant                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (59)                                   
      Adenoma                                          2 (3%)                                 1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
   Adrenal Medulla                                    (60)         (60)         (60)         (58)                                   
      Pheochromocytoma Benign                          2 (3%)                                 1 (2%)                                
   Islets, Pancreatic                                 (60)         (59)         (60)         (60)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (59)         (60)         (60)         (60)                                   
      Pars Distalis, Adenoma                          19 (32%)     30 (50%)     26 (43%)     20 (33%)                               
      Pars Distalis, Adenoma, Multiple                              2 (3%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)                                             
      C-Cell, Adenoma                                  9 (15%)      5 (8%)       2 (3%)       5 (8%)                                
      C-Cell, Carcinoma                                1 (2%)       3 (5%)       3 (5%)       1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (57)         (54)         (53)                                   
      Adenoma                                         12 (20%)      8 (14%)      3 (6%)       3 (6%)                                
      Carcinoma                                        2 (3%)       4 (7%)       3 (6%)                                             
      Bilateral, Adenoma                                            1 (2%)                                                          
   Ovary                                              (60)         (59)         (60)         (60)                                   
      Granulosa Cell Tumor Malignant                                                          1 (2%)                                
      Granulosa-Theca Tumor Malignant                               1 (2%)                                                          
   Uterus                                             (60)         (59)         (60)         (60)                                   
      Hemangioma                                                                              1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal                                   11 (18%)      7 (12%)     15 (25%)     16 (27%)                               
      Sarcoma Stromal                                               1 (2%)                    1 (2%)                                
   Vagina                                             (2)          (1)          (3)          (6)                                    
      Fibroma                                                                    1 (33%)                                            
      Granular Cell Tumor Benign                                                              1 (17%)                               
      Hemangioma                                                                              1 (17%)                               
      Leiomyoma                                        1 (50%)                                                                      
      Leiomyosarcoma                                                                          1 (17%)                               
      Squamous Cell Papilloma                                                    1 (33%)      1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (8)          (4)          (4)          (4)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                          1 (25%)                                            
   Lymph Node, Mandibular                             (60)         (60)         (59)         (59)                                   
   Lymph Node, Mesenteric                             (59)         (58)         (59)         (59)                                   
   Spleen                                             (60)         (59)         (60)         (59)                                   
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
   Thymus                                             (57)         (55)         (58)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (59)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                                                  1 (2%)       1 (2%)                                
      Fibroadenoma                                    17 (28%)     12 (20%)     13 (22%)     14 (23%)                               
      Fibroadenoma, Multiple                           6 (10%)     35 (58%)     39 (66%)     42 (70%)                               
   Skin                                               (59)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Pinna, Melanoma Malignant                                     1 (2%)                                                          
      Pinna, Neural Crest Tumor                                                               1 (2%)                                
      Sebaceous Gland, Adenoma                                                                1 (2%)                                
      Subcutaneous Tissue, Fibroma                     3 (5%)       3 (5%)      18 (30%)     19 (32%)                               
      Subcutaneous Tissue, Fibroma, Multiple                                                  1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          4 (7%)       2 (3%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                             1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Neural Crest Tumor                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)          (1)                                    
      Lipoma                                           1 (100%)                                                                     
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                    3 (5%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Sarcoma, Metastatic, Liver                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (1)                       (3)                                    
      Adenoma                                          1 (50%)                                1 (33%)                               
      Carcinoma                                        1 (50%)      1 (100%)                  2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
   Urinary Bladder                                    (60)         (59)         (60)         (60)                                   
      Papilloma                                                                  1 (2%)       1 (2%)                                
      Squamous Cell Papilloma, Multiple                                                       1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            21 (35%)      6 (10%)      4 (7%)       5 (8%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
                                                                                                                                    
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant                                                         1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            54          58          60          60                                       
     Total Primary Neoplasms                          113         131         147         165                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          57          59          59                                       
     Total Benign Neoplasms                            88         112         126         143                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          16          18          20                                       
     Total Malignant Neoplasms                         25          19          20          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           1                                                   
     Total Metastatic Neoplasm                                      3           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1           1                                       
     Total Uncertain Neoplasms                                                  1           1                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          70           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           35           48           53                                     
    Natural Death                                      3            7            6            7                                     
    Accidently Killed                                                            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           18            3                                                  
    Natural Death                                      1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (60)         (60)                                   
      Polyp Adenomatous                                1 (2%)                                 1 (2%)                                
   Intestine Large, Cecum                             (60)         (60)         (60)         (58)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (59)         (60)         (58)         (53)                                   
   Intestine Small, Ileum                             (58)         (58)         (58)         (58)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Adenoma                           2 (3%)       2 (3%)       3 (5%)       7 (12%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Hepatocholangiocarcinoma                                      1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (16)         (6)          (5)          (4)                                    
      Fibroma                                                                    1 (20%)                                            
      Fibrosarcoma                                                  1 (17%)                                                         
      Lipoma                                                        1 (17%)                                                         
   Oral Mucosa                                                                  (1)          (1)                                    
      Hemangioma                                                                              1 (100%)                              
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Acinus, Adenoma                                                            1 (2%)                                             
      Islets, Pancreatic, Adenoma                      1 (2%)                                                                       
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                 1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
   Tongue                                             (1)                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (59)                                   
      Neuroblastoma                                                                           1 (2%)                                
      Pheochromocytoma Malignant                       2 (3%)                                                                       
      Pheochromocytoma Benign                          1 (2%)       4 (7%)       6 (10%)      2 (3%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          2 (3%)                                                                       
      Carcinoma                                                     2 (3%)                                                          
   Parathyroid Gland                                  (58)         (55)         (59)         (58)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (59)         (60)         (58)         (59)                                   
      Pars Distalis, Adenoma                          11 (19%)      9 (15%)      3 (5%)       9 (15%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                 1 (2%)                                                          
      Sarcoma, Metastatic, Salivary Glands                                       1 (2%)                                             
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  9 (15%)      6 (10%)                   1 (2%)                                
      C-Cell, Carcinoma                                             4 (7%)                    1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)          (21)         (33)         (46)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (60)         (59)         (58)         (56)                                   
      Adenoma                                          2 (3%)       3 (5%)       2 (3%)       1 (2%)                                
      Carcinoma                                        2 (3%)       2 (3%)                    1 (2%)                                
   Prostate                                           (60)         (59)         (60)         (60)                                   
      Ventral, Adenoma                                 2 (3%)                                                                       
   Testes                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           43 (72%)     34 (57%)     32 (53%)     17 (28%)                               
      Interstitial Cell, Adenoma                      12 (20%)     19 (32%)     19 (32%)     29 (48%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (16)         (14)         (4)          (9)                                    
   Lymph Node, Mandibular                             (58)         (59)         (58)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                 1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (58)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (56)         (54)         (55)         (55)                                   
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (47)         (46)         (43)                                   
      Fibroadenoma                                                  7 (15%)      9 (20%)      2 (5%)                                
      Fibroadenoma, Multiple                                                     1 (2%)                                             
      Hemangioma                                                    1 (2%)                                                          
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                               2 (3%)                                 1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Keratoacanthoma                                  5 (8%)       3 (5%)       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibroma                     4 (7%)      21 (35%)     13 (22%)     24 (40%)                               
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)      25 (42%)     39 (65%)     35 (58%)                               
      Subcutaneous Tissue, Fibrosarcoma                             7 (12%)     13 (22%)     15 (25%)                               
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                4 (7%)       5 (8%)                                
      Subcutaneous Tissue, Hemangioma                               2 (3%)                                                          
      Subcutaneous Tissue, Hemangiopericytoma                                                 1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                   4 (7%)      12 (20%)     13 (22%)                               
      Subcutaneous Tissue, Lipoma, Multiple                                      1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)                    1 (2%)                                
   Skeletal Muscle                                    (1)          (5)          (3)                                                 
      Rhabdomyosarcoma                                              1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
      Granular Cell Tumor Benign                                    1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                 1 (2%)                                                          
      Cranial Nerve, Schwannoma Malignant                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       5 (8%)       1 (2%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Nose                                               (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)          (1)                                    
      Schwannoma Malignant, Metastatic, Brain                                    1 (50%)                                            
   Harderian Gland                                                 (1)          (1)                                                 
      Schwannoma Malignant, Metastatic, Brain                                    1 (100%)                                           
   Zymbal's Gland                                                  (2)                       (2)                                    
      Carcinoma                                                     2 (100%)                  2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
   Urinary Bladder                                    (60)         (60)         (60)         (59)                                   
      Hemangioma                                                                              1 (2%)                                
      Papilloma                                        1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Transitional Epithelium, Papilloma                            2 (3%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (3%)                                                          
      Leukemia Mononuclear                            30 (50%)     21 (35%)      3 (5%)       3 (5%)                                
      Lymphoma Malignant                                                         1 (2%)                                             
      Mesothelioma Malignant                           2 (3%)      20 (33%)     29 (48%)     44 (73%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00  
Route: DOSED FEED                                                                                                 Time: 09:26:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      1250 PPM     2000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          60          57          60                                       
     Total Primary Neoplasms                          144         221         202         224                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 60          58          55          59                                       
     Total Benign Neoplasms                           102         154         147         148                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37          47          42          51                                       
     Total Malignant Neoplasms                         42          67          55          76                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          4           3           1                                       
     Total Metastatic Neoplasm                                      7           4           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
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