Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/12075

TDMS Study 05203-08 Pathology Tables

NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00
Route: DOSED FEED                                                                                                 Time: 09:33:33

                                                   RATS, FINAL#1; CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:  88-72-2

       Lock Date:  12/10/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 PPM
                               Include 004    625 PPM
                               Include 006    1250 PPM
                               Include 008    2000 PPM
                               Include 001    0 PPM
                               Include 003    625 PPM
                               Include 005    1250 PPM
                               Include 007    2000 PPM




























                                                              Page   1


NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 3| 3| 3| 4| 3| 3| 5| 5| 5| 0| 5| 5| 5| 5| 9| 6| 1| 1| 1| 0| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Crypt, Diverticulum                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X  X                 X        X  X              X              X  X     X|             
      Eosinophilic Focus                   |                               X                                X         |             
      Hepatodiaphragmatic Nodule           |          X           X              X                    X               |             
      Infiltration Cellular, Mixed Cell    |       3              1        1        1                          3      |             
      Mixed Cell Focus                     | X                                                     X                  |             
      Regeneration, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia               | 1                    1                                                   |             
      Centrilobular, Necrosis              |          2                                   1                           |             
      Hepatocyte, Vacuolization Cytoplasmic|                3           3                                             |             
      Kupffer Cell, Pigmentation           |          2     2                                                         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +  +              +        +                                 |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |             3  3              3        3                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1                                                  2              1   |             
      Acinus, Hyperplasia, Focal           |                                                                         1|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 3| 3| 3| 4| 3| 3| 5| 5| 5| 0| 5| 5| 5| 5| 9| 6| 1| 1| 1| 0| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                1                                                         |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           3                              |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                           +  +                           |             
      Inflammation, Chronic                |                                           3                              |             
      Malformation                         |                                           X  X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1     2                 1                       1  2  2        1  2|             
      Myocardium, Fibrosis                 |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 3     3                 3  3        3                                3   |             
      Degeneration, Fatty                  |          1                                   1  3     3                  |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |       2  2                                                               |             
      Hypertrophy, Focal                   |                                        3              2                  |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3              1                           |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 3| 3| 3| 4| 3| 3| 5| 5| 5| 0| 5| 5| 5| 5| 9| 6| 1| 1| 1| 0| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    4                                                                     |             
      Pars Distalis, Cyst                  |    3     3     2        3  3  3              3  3              3     3  3|             
      Pars Distalis, Hyperplasia, Focal    |    2                                   2                                 |             
      Pars Intermedia, Cyst                |          3              3                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                  3                                       |             
      C-Cell, Hyperplasia                  | 2        1  1        2     3  1     1  2        2  1        3     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                         2     2                                          |             
      Inflammation, Chronic                |                               2                          3               |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3     3              3                                3              3   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Hydrometra                           |                               3                 3              3  3  3  2|             
      Hyperplasia, Cystic                  |                   1  2                             3  1           3      |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 3| 3| 3| 4| 3| 3| 5| 5| 5| 0| 5| 5| 5| 5| 9| 6| 1| 1| 1| 0| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                           4                              |             
      Myelofibrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +                 +                                       |             
      Mediastinal, Hemorrhage              |                                  2                                       |             
      Mediastinal, Pigmentation            |                3                 3                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                   2                                                  2   |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Pigmentation                         | 2              2  3     2     2  2     2     2  2  2  2     2  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     1                                    |             
      Hematopoietic Cell Proliferation     |       1           2              1              1           2            |             
      Necrosis                             |                                              4                           |             
      Pigmentation                         | 2  2  2     3     3  2  2     3  2     2  4     2     3     2  2  2  2  3|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       1  1  1     2  1           1     2        2     2     2        2  2|             
      Hyperplasia                          |    1                    1           2           2  3           2     1   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 3| 3| 3| 4| 3| 3| 5| 5| 5| 0| 5| 5| 5| 5| 9| 6| 1| 1| 1| 0| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
      Cranium, Osteopetrosis               | 3                                                                        |             
      Femur, Osteopetrosis                 | 2  2     3     3           3                                2            |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     2           2        4               |             
      Hydrocephalus                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                +                                                         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  3  3  1  3  1  2  2  1     1  1  1     1  1  1  2  2  1  1     1  1  2|             
      Alveolar Epithelium, Hyperplasia     |       1                                   2                              |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                          +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 3| 3| 3| 4| 3| 3| 5| 5| 5| 0| 5| 5| 5| 5| 9| 6| 1| 1| 1| 0| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 1                                                                        |             
      Inflammation, Chronic                |                                                    2                     |             
      Nephropathy                          | 1  1  1  1  1     1  1  1  1  1  1  1  1     1  1  1  1  1  1  1     1  1|             
      Renal Tubule, Degeneration, Hyaline  |             1                       2           2                        |             
      Renal Tubule, Necrosis               |                1                                                         |             
      Renal Tubule, Pigmentation           |          3                 4        1           1                        |             
      Transitional Epithelium, Hyperplasia |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 0| 1|             
                                           | 7| 4| 4| 4| 4| 3| 3| 3| 3| 3| 5| 1| 5| 1| 5| 5| 5| 5| 5| 2| 0| 0| 2| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Crypt, Diverticulum                  |             X                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X     X  X  X   |             
      Clear Cell Focus                     |    X        X        X  X        X                             X         |             
      Eosinophilic Focus                   |          X     X                                X                        |             
      Hepatodiaphragmatic Nodule           |             X                                X           X               |             
      Infiltration Cellular, Mixed Cell    |                2     3  2                 3  1  1                        |             
      Mixed Cell Focus                     |    X        X                                                  X         |             
      Regeneration, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia               |                1              1                                   2      |             
      Centrilobular, Necrosis              |                                        2                                 |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  4     4                                 |             
      Kupffer Cell, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +           +                    +     +              +            |             
      Accessory Spleen                     |                                              X              X            |             
      Fat, Necrosis                        |       2           2                    3                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                          2              1  1     1           2  1   |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 0| 1|             
                                           | 7| 4| 4| 4| 4| 3| 3| 3| 3| 3| 5| 1| 5| 1| 5| 5| 5| 5| 5| 2| 0| 0| 2| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                                        3            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |             3                                                            |             
      Epithelium, Hyperplasia              |       1     2                    2     3                    4            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |             2                          4                                 |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Malformation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3        2     1  1  1     1              1  2     1     1            |             
      Myocardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 3                                      3                                 |             
      Degeneration, Fatty                  |    4  3     3     1           1  4     3                                 |             
      Hyperplasia, Diffuse                 |    4        3                          3                                 |             
      Hyperplasia, Focal                   |          1                 1              2                       1      |             
      Hypertrophy, Focal                   |                   1                       2                              |             
      Necrosis                             |                                                                         3|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        3        1           3                 1                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 0| 1|             
                                           | 7| 4| 4| 4| 4| 3| 3| 3| 3| 3| 5| 1| 5| 1| 5| 5| 5| 5| 5| 2| 0| 0| 2| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                        4                          3      |             
      Pars Distalis, Cyst                  |          3     3              3  3           3              3     3  1   |             
      Pars Distalis, Hyperplasia, Focal    |          2        2           2     1  4                             1  1|             
      Pars Intermedia, Cyst                |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       2           1  2  1        1     1                    1  3  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                               3  4                                       |             
      Hyperplasia                          |                                  2                       1               |             
      Inflammation, Chronic                |                                  3              2                        |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                             3        3                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |          3                                                               |             
      Hyperplasia, Cystic                  |                                  2                                       |             
      Inflammation, Chronic                |                               4                                      4   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 0| 1|             
                                           | 7| 4| 4| 4| 4| 3| 3| 3| 3| 3| 5| 1| 5| 1| 5| 5| 5| 5| 5| 2| 0| 0| 2| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |       3                                                              3   |             
      Infiltration Cellular, Histiocyte    |          2                                                               |             
      Myelofibrosis                        |                         4                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +           +                    +     +     +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                            2           3                          2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                   2      |             
      Hemorrhage                           |       2                                                                  |             
      Hyperplasia, Lymphoid                | 2        2                                                               |             
      Pigmentation                         | 2  2           2  2  2  2     2     2     2  2     2  2  2               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    4        1                             2        1                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    3  1  1  2  1              1           2        1                 4   |             
      Necrosis                             |                                                                         3|             
      Pigmentation                         | 4  2           2              2     3        3  2  3  3  3     3         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  4  2  1  3  3  1     1  1  2  2  1  3  3           3  2  1  2  1  1  3|             
      Hyperplasia                          |             2  2     3        1           1                             2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 0| 1|             
                                           | 7| 4| 4| 4| 4| 3| 3| 3| 3| 3| 5| 1| 5| 1| 5| 5| 5| 5| 5| 2| 0| 0| 2| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
      Cranium, Osteopetrosis               |    2                                                                     |             
      Femur, Osteopetrosis                 |    3                                            3                        |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             3                                            3     3         |             
      Hydrocephalus                        |             2                          1                                 |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1                                                                     |             
      Infiltration Cellular, Histiocyte    | 1  2  2  2  2  1  2  2  2  2  2  1  1     2  2  2     1  1  4  1  2      |             
      Alveolar Epithelium, Hyperplasia     | 1              2                    1                       3            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                    X                     |             
      Inflammation, Chronic                |                                                    1                     |             
      Respiratory Epithelium, Hyperplasia  |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |             +     +                    +                                 |             
      Cataract                             |                   3                                                      |             
      Hemorrhage                           |                                        3                                 |             
      Inflammation, Chronic                |             4                                                            |             
      Retina, Degeneration                 |                   4                    3                                 |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 0| 1|             
                                           | 7| 4| 4| 4| 4| 3| 3| 3| 3| 3| 5| 1| 5| 1| 5| 5| 5| 5| 5| 2| 0| 0| 2| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                               2                                          |             
      Inflammation, Chronic                |             3                                                            |             
      Nephropathy                          | 2  4  1  1  4  1     1  1     1        1  1  1  1  1  1  1  3  1  1  1  1|             
      Renal Tubule, Degeneration, Hyaline  |                            1     3                    1        2         |             
      Renal Tubule, Necrosis               |                                        3                                 |             
      Renal Tubule, Pigmentation           |                1           1                                             |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|                                            |            |
                                           | 3| 3| 3| 3| 3| 1| 1| 1| 1| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Crypt, Diverticulum                  |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 3           1                                                            |      2  2.0|
      Basophilic Focus                     |    X  X  X  X  X  X  X  X                                                |     51     |
      Clear Cell Focus                     |    X                                                                     |     16     |
      Eosinophilic Focus                   |                                                                          |      5     |
      Hepatodiaphragmatic Nodule           | X                 X                                                      |      9     |
      Infiltration Cellular, Mixed Cell    | 3        1  1           1                                                |     15  1.8|
      Mixed Cell Focus                     |                         X                                                |      6     |
      Regeneration, Focal                  |                            3                                             |      1  3.0|
      Bile Duct, Hyperplasia               | 1                          2                                             |      7  1.3|
      Centrilobular, Necrosis              |                                                                          |      3  1.7|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      4  3.5|
      Kupffer Cell, Pigmentation           |                            3                                             |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Accessory Spleen                     |                                                                          |      2     |
      Fat, Necrosis                        |                                                                          |      7  2.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|                                            |            |
                                           | 3| 3| 3| 3| 3| 1| 1| 1| 1| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |          1           1                                                   |     13  1.4|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Malformation                         |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                1  1  1                                                   |     22  1.4|
      Myocardium, Fibrosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      8  3.0|
      Degeneration, Fatty                  |       1           1                                                      |     13  2.2|
      Hyperplasia, Diffuse                 |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|                                            |            |
                                           | 3| 3| 3| 3| 3| 1| 1| 1| 1| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia, Focal                   |       2        2        2                                                |      9  1.7|
      Hypertrophy, Focal                   | 2                 2                                                      |      6  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                            1                                             |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Pars Distalis, Angiectasis           |       2              2     1                                             |      6  2.7|
      Pars Distalis, Cyst                  |          3        3  3                                                   |     22  2.9|
      Pars Distalis, Hyperplasia, Focal    |       3              3     2                                             |     12  2.1|
      Pars Intermedia, Cyst                |                                                                          |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |                         2                                                |     22  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      2  3.5|
      Hyperplasia                          |                         2                                                |      5  1.8|
      Inflammation, Chronic                |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                3                                                         |      9  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|                                            |            |
                                           | 3| 3| 3| 3| 3| 1| 1| 1| 1| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |                                                                          |      7  2.9|
      Hyperplasia, Cystic                  | 2        1                                                               |      8  1.9|
      Inflammation, Chronic                |                                                                          |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   8        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                            3                                             |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |       2                                                                  |      4  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Pigmentation                         |             2           2                                                |     31  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |    1                                                                     |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |    2     1  1  2  1  2  2  2                                             |     22  1.6|
      Necrosis                             |                                                                          |      2  3.5|
      Pigmentation                         | 2     3  3  1  2     2  3                                                |     36  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|                                            |            |
                                           | 3| 3| 3| 3| 3| 1| 1| 1| 1| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           | 2  3     2  2  2        1  1                                             |     40  1.9|
      Hyperplasia                          |                1                                                         |     14  1.7|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               |                                                                          |      2  2.5|
      Femur, Osteopetrosis                 |                                                                          |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      6  2.8|
      Hydrocephalus                        |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|                                            |            |
                                           | 3| 3| 3| 3| 3| 1| 1| 1| 1| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hemorrhage                           |                                                                          |      2  1.0|
      Infiltration Cellular, Histiocyte    | 1  1  2     1  1  1  2  2  2                                             |     52  1.6|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |       X                                                                  |      2     |
      Inflammation, Chronic                |       2                                                                  |      2  1.5|
      Respiratory Epithelium, Hyperplasia  |       1                                                                  |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infarct                              |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1                                             |     53  1.2|
      Renal Tubule, Degeneration, Hyaline  |    2                       3                                             |      9  1.9|
      Renal Tubule, Necrosis               |                                                                          |      2  2.0|
      Renal Tubule, Pigmentation           |    1                    1  3                                             |      9  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 0| 9| 3|             
                                           | 4| 4| 2| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 9| 5| 6| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                       2            |             
      Basophilic Focus                     | X  X     X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X|             
      Clear Cell Focus                     |          X  X     X           X  X  X     X  X  X  X     X  X           X|             
      Eosinophilic Focus                   |    X           X        X  X                 X                    X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Hepatodiaphragmatic Nodule           |    X     X              X                          X     X  X            |             
      Infiltration Cellular, Mixed Cell    |                   1        1           1              2     3     1      |             
      Mixed Cell Focus                     |             X                 X                                X         |             
      Necrosis, Focal                      |          1                                                               |             
      Regeneration, Focal                  |                                              2                           |             
      Bile Duct, Hyperplasia               |                                                          1               |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                       3                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1        1              1  2                                    |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 0| 9| 3|             
                                           | 4| 4| 2| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 9| 5| 6| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                       1                  |             
      Epithelium, Hyperplasia              |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1                                2              1        1|             
      Myocardium, Fibrosis                 |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             3           3           3                                    |             
      Degeneration, Fatty                  |             2                                      1                     |             
      Hyperplasia, Diffuse                 |                                                       2                  |             
      Hyperplasia, Focal                   |          1                       1                 1                     |             
      Hypertrophy, Focal                   | 3           2                                                            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     3                                3   |             
      Pars Distalis, Cyst                  |                   3        3  3     3  3  3              3     3        3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 0| 9| 3|             
                                           | 4| 4| 2| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 9| 5| 6| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                               2                                         2|             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 2  1           2        1  1              1  2  1  1              2      |             
      Follicle, Cyst                       |                                  3                                3      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |       2              2                                                   |             
      Cyst                                 |                                                                         3|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                 3        3           3         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                         2     2                          3               |             
      Hyperplasia, Cystic                  |                                              3              1            |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                          2               |             
      Infiltration Cellular, Histiocyte    |                                                          4               |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 0| 9| 3|             
                                           | 4| 4| 2| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 9| 5| 6| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |    2                                                  1           3      |             
      Hyperplasia, Lymphoid                |    2                    2                 3              2               |             
      Pigmentation                         |    2     2     2     2  2     2  2              2     2     2  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       3                  |             
      Pigmentation                         |                               2                       2           2      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Hematopoietic Cell Proliferation     | 2  1     2  1  1  1  2     2     1        1  2  1  1  2  1           1  1|             
      Pigmentation                         |    2        1  1  2  3  3  1  1  3  2  2  3     3  2  3  2  2     3  2  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    1           3  3  3  3        2  2  1  1     3  2  2  2  3            |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 3  3        2           4  3  2  1  1  2     1  2     1  3     4  4  4   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                 2              3         |             
      Femur, Osteopetrosis                 |                               2                                3         |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 0| 9| 3|             
                                           | 4| 4| 2| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 9| 5| 6| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2                                            2     4     4     4      |             
      Hydrocephalus                        |                      3                                      3            |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +        +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                             +        +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 3                                                                        |             
      Infiltration Cellular, Histiocyte    | 2  1  2  2  1  1  1  1  2  2  2  1  1  2  1  1  2  2  1  2  1  2  2  1  1|             
      Alveolar Epithelium, Hyperplasia     |             3           3     1                    1                    1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +                                                                 +      |             
      Cataract                             | 3                                                                        |             
      Inflammation, Chronic                |                                                                   4      |             
      Retina, Degeneration                 | 4                                                                        |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                                                |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          |    1     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                1                 1              3                 1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 0| 9| 3|             
                                           | 4| 4| 2| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 9| 5| 6| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Renal Tubule, Pigmentation           |                                  1              1                 1      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3|             
                                           | 4| 5| 4| 4| 4| 1| 5| 5| 8| 5| 5| 5| 5| 9| 5| 1| 1| 1| 1| 1| 5| 4| 5| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          3               |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |          X  X           X  X        X        X  X        X  X     X  X   |             
      Eosinophilic Focus                   | X  X                    X                                            X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                 X              X  X                 X                  |             
      Infiltration Cellular, Mixed Cell    | 1     1                    1                    1        2               |             
      Mixed Cell Focus                     |          X           X        X                    X                     |             
      Necrosis, Focal                      |                                                                          |             
      Regeneration, Focal                  |                         3                                                |             
      Bile Duct, Hyperplasia               |                                                       1                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                                                         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Necrosis                        |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                            2     1               |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3|             
                                           | 4| 5| 4| 4| 4| 1| 5| 5| 8| 5| 5| 5| 5| 9| 5| 1| 1| 1| 1| 1| 5| 4| 5| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                    2|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                        X                                 |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                        4                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           1        1     1  1     2     2        1              2  2   |             
      Myocardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       3     3                             3  3              3        3   |             
      Degeneration, Fatty                  |                            3     3        2        1           1  1     2|             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                1                                      2        2         |             
      Hypertrophy, Focal                   |                            3     3                 2                    2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     4        4                       4   |             
      Pars Distalis, Cyst                  |    3  3  3              3  3        3           3                    3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3|             
                                           | 4| 5| 4| 4| 4| 1| 5| 5| 8| 5| 5| 5| 5| 9| 5| 1| 1| 1| 1| 1| 5| 4| 5| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 3     3           1           3                                          |             
      Pars Intermedia, Angiectasis         |                      3                       2                           |             
      Pars Intermedia, Cyst                |             3                                                            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                               3                                          |             
      C-Cell, Hyperplasia                  |          1           3  1        1  3              3     2           1   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                           2                              |             
      Cyst                                 |                   4     4                                                |             
      Hyperplasia                          |                                  2                                       |             
      Inflammation, Chronic                |                   2              2  2     2                              |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3  3                          3     3                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |             2                                         3           2      |             
      Hyperplasia, Cystic                  | 2     3                    2                                             |             
      Inflammation, Chronic                |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                        2     2         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +  +           +              M                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3|             
                                           | 4| 5| 4| 4| 4| 1| 5| 5| 8| 5| 5| 5| 5| 9| 5| 1| 1| 1| 1| 1| 5| 4| 5| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hemorrhage              |                            3                                             |             
      Mediastinal, Pigmentation            |                            3                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              2                          2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Pigmentation                         |       2        2  2  2        2  2     2  3  2  2  2                 2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   3                                                      |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 3     1  1     1  1  1        1     1     2  1           1        1  1   |             
      Pigmentation                         |       3  2     3  3  3     1  3     3     2  1  2  1  3     2  3  3      |             
      Lymphoid Follicle, Atrophy           |                                                                3         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2  1     3                    2     2  2     2  2  2        3  3   |             
      Galactocele                          |                                     4                                    |             
      Hyperplasia                          | 1  2        4  1     2  3     1  4           1        3     2  3     1  3|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |          3                       3                       3               |             
      Femur, Osteopetrosis                 |          2                    2           2     2        2               |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3|             
                                           | 4| 5| 4| 4| 4| 1| 5| 5| 8| 5| 5| 5| 5| 9| 5| 1| 1| 1| 1| 1| 5| 4| 5| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                4                          4                 3           3|             
      Hydrocephalus                        |                3                          2                              |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       1                  |             
      Infiltration Cellular, Histiocyte    | 2     2  2  2     1  1     1  1  2  1     1  2  2  2  2  2  1  1  1     1|             
      Alveolar Epithelium, Hyperplasia     |                      1  3  2                    1        3  2            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cataract                             |                                                       3                  |             
      Inflammation, Chronic                |                                                                          |             
      Retina, Degeneration                 |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 1     1  1  1  2  1  1  1  1  1     1  2  1     1     1     1     1  1  1|             
      Renal Tubule, Cytoplasmic Alteration |                         2                                                |             
      Renal Tubule, Degeneration, Hyaline  | 2  2                                      2                 2        2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3|             
                                           | 4| 5| 4| 4| 4| 1| 5| 5| 8| 5| 5| 5| 5| 9| 5| 1| 1| 1| 1| 1| 5| 4| 5| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Renal Tubule, Pigmentation           |    1     1              1                 2                 1        1  1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 0| 3| 3|                                            |            |
                                           | 1| 1| 1| 1| 1| 3| 2| 5| 3| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      3  2.3|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     56     |
      Clear Cell Focus                     | X     X  X  X           X  X                                             |     30     |
      Eosinophilic Focus                   |                   X  X                                                   |     12     |
      Hematopoietic Cell Proliferation     |                2     2                                                   |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X  X                                                                  |     13     |
      Infiltration Cellular, Mixed Cell    |                                                                          |     11  1.4|
      Mixed Cell Focus                     |       X  X                                                               |      9     |
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Regeneration, Focal                  |                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 0| 3| 3|                                            |            |
                                           | 1| 1| 1| 1| 1| 3| 2| 5| 3| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |       1     1     2                                                      |     10  1.4|
      Acinus, Hyperplasia, Focal           |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Perforation                          |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                2                                                         |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |          2              1                                                |     16  1.4|
      Myocardium, Fibrosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                            3                                             |     10  3.0|
      Degeneration, Fatty                  |       3           1                                                      |     11  1.8|
      Hyperplasia, Diffuse                 |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      6  1.3|
      Hypertrophy, Focal                   |                   1                                                      |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                   1                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 0| 3| 3|                                            |            |
                                           | 1| 1| 1| 1| 1| 3| 2| 5| 3| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      5  3.6|
      Pars Distalis, Cyst                  |    3        3  3                                                         |     20  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      6  2.3|
      Pars Intermedia, Angiectasis         |                                                                          |      2  2.5|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  | 2        1  1        1  3  1                                             |     24  1.6|
      Follicle, Cyst                       |                                                                          |      2  3.0|
      Follicular Cell, Hyperplasia         |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |                                                                          |      3  2.0|
      Cyst                                 |                         3                                                |      4  3.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      8  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hydrometra                           |                                                                          |      6  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 0| 3| 3|                                            |            |
                                           | 1| 1| 1| 1| 1| 3| 2| 5| 3| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hyperplasia, Cystic                  |          1                                                               |      6  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                2     4                                                   |      7  2.4|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                         2                                                |      3  2.0|
      Hemorrhage                           |                         1                                                |      4  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.2|
      Pigmentation                         | 2  2  2  2        2        2                                             |     33  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |       3                                                                  |      3  3.0|
      Pigmentation                         |       2                                                                  |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 1  1  1     1  3  1  4     1                                             |     38  1.4|
      Pigmentation                         | 2  2  1  2  1     3     3  2                                             |     44  2.2|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 0| 3| 3|                                            |            |
                                           | 1| 1| 1| 1| 1| 3| 2| 5| 3| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |       2           3  2  1  1                                             |     30  2.1|
      Galactocele                          |                                                                          |      1  4.0|
      Hyperplasia                          | 1  2     4  1  3        1                                                |     36  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               | 2                                                                        |      6  2.7|
      Femur, Osteopetrosis                 | 3                       2                                                |      9  2.2|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                   4                                                      |     10  3.4|
      Hydrocephalus                        |                                                                          |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |    2  1  1  1  1  2  1  1  1                                             |     54  1.4|
      Alveolar Epithelium, Hyperplasia     |       4     2              2                                             |     14  2.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 0| 3| 3|                                            |            |
                                           | 1| 1| 1| 1| 1| 3| 2| 5| 3| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic                |             1                                                            |      1  1.0|
      Nephropathy                          |    1     1        1        1                                             |     45  1.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |     10  1.8|
      Renal Tubule, Pigmentation           |                                                                          |     10  1.1|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 3| 7| 7|             
                             DAY ON TEST   | 2| 0| 0| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 7| 3| 3|             
                                           | 5| 7| 7| 4| 4| 4| 4| 4| 4| 4| 8| 6| 4| 4| 4| 3| 3| 3| 6| 3| 7| 6| 0| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |       X  X     X        X  X     X        X     X                    X  X|             
      Degeneration, Cystic                 |                                        2                                 |             
      Eosinophilic Focus                   |    X  X     X              X        X  X        X        X  X  X         |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X  X                                      X        X               |             
      Infiltration Cellular, Mixed Cell    |                                                          3        2      |             
      Mixed Cell Focus                     |                      X  X                          X                     |             
      Necrosis, Focal                      |                      1                    1                       2      |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                               3                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                            3                                             |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                          2  1                 1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 3| 7| 7|             
                             DAY ON TEST   | 2| 0| 0| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 7| 3| 3|             
                                           | 5| 7| 7| 4| 4| 4| 4| 4| 4| 4| 8| 6| 4| 4| 4| 3| 3| 3| 6| 3| 7| 6| 0| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Hyperplasia, Focal           |                         3                                                |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                       2        3                  |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                       1                  |             
      Ulcer                                |                               2                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1           1     1              1                              |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    3           3                                3                        |             
      Degeneration, Fatty                  |                1  2        2  4              2  2              2         |             
      Hyperplasia, Focal                   |                   2                    2     2                           |             
      Hypertrophy, Focal                   |    2                                      2     2                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 3| 7| 7|             
                             DAY ON TEST   | 2| 0| 0| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 7| 3| 3|             
                                           | 5| 7| 7| 4| 4| 4| 4| 4| 4| 4| 8| 6| 4| 4| 4| 3| 3| 3| 6| 3| 7| 6| 0| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2                                2                                    |             
      Pars Distalis, Cyst                  |       3              3  3           3  3  3  3  3  3        3        3  3|             
      Pars Distalis, Hyperplasia, Focal    |    3           3                                2  3        2  2         |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       1        1  1        2  2                 1  1                     |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M|             
      Atrophy                              |             3                                      2  2                  |             
      Cyst                                 |             3                             4                              |             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Chronic                |                2                                                         |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3  3                 3     3     3  3|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                2                                                         |             
      Hyperplasia, Cystic                  |          1                    2                 2              4     2   |             
      Inflammation, Chronic                |                                                                   4      |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                               +                    +     +               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3        2                    4                 2        2  4  3      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 3| 7| 7|             
                             DAY ON TEST   | 2| 0| 0| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 7| 3| 3|             
                                           | 5| 7| 7| 4| 4| 4| 4| 4| 4| 4| 8| 6| 4| 4| 4| 3| 3| 3| 6| 3| 7| 6| 0| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                  +     +                 +               |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         2                                               2|             
      Pigmentation                         | 2        2     2        2        2  2  2     2     2        2            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2              1                          1                              |             
      Pigmentation                         |                                           2                              |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  1  2  2  1     2  2  2     4  2  1     2  1     3     2  4  3  1  3|             
      Pigmentation                         | 3  3     3     3     2  2  2        3  1  2  2  3     3              2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    1  2  2     2           2        3     1  1     1  1  1     3  1     1|             
      Hyperplasia                          |          1     1  3  1  3  1  3                       2  3           2   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                         2                                                |             
      Femur, Osteopetrosis                 |                         2              2                 3              4|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 3| 7| 7|             
                             DAY ON TEST   | 2| 0| 0| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 7| 3| 3|             
                                           | 5| 7| 7| 4| 4| 4| 4| 4| 4| 4| 8| 6| 4| 4| 4| 3| 3| 3| 6| 3| 7| 6| 0| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 4                                                                        |             
      Infiltration Cellular, Histiocyte    |    2  2  1  1  2  2  1  1  1  1  2  1  1  1  1     1  2  2  1     1  2  1|             
      Alveolar Epithelium, Hyperplasia     |          4           2     2                 1  1        2     2         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      3                                                   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                                  |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                                                    2                     |             
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1        1  1     1  1  1        1  1  1  1  1|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                     1     2           1                  |             
      Renal Tubule, Pigmentation           |                                     1  1  1           1                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 3| 7| 7|             
                             DAY ON TEST   | 2| 0| 0| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 7| 3| 3|             
                                           | 5| 7| 7| 4| 4| 4| 4| 4| 4| 4| 8| 6| 4| 4| 4| 3| 3| 3| 6| 3| 7| 6| 0| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                         2|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 0| 3| 3| 3| 0| 3| 3| 7| 3| 6| 3|             
                                           | 2| 3| 3| 3| 3| 5| 5| 5| 5| 5| 3| 1| 1| 8| 6| 1| 1| 1| 6| 1| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                3                       2           2|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X  X  X  X     X                 X  X  X     X  X  X  X  X           X  X|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                X           X     X        X        X              X  X  X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X        X           X            |             
      Infiltration Cellular, Mixed Cell    |             1           1                                         1      |             
      Mixed Cell Focus                     |             X              X     X     X        X     X     X            |             
      Necrosis, Focal                      |                                                                          |             
      Centrilobular, Necrosis              |                                           2                    3         |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                              +              +            |             
      Accessory Spleen                     |                                              X                           |             
      Fat, Necrosis                        |                                                             3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       1        1     1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 0| 3| 3| 3| 0| 3| 3| 7| 3| 6| 3|             
                                           | 2| 3| 3| 3| 3| 5| 5| 5| 5| 5| 3| 1| 1| 8| 6| 1| 1| 1| 6| 1| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                         2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2        2                             2                    2  2      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1     2  1                          1              1  1            |             
      Thrombosis                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   3                                                      |             
      Degeneration, Fatty                  |          2  1        2              3  2                    2            |             
      Hyperplasia, Focal                   |    1  2           1        1                                      2  2   |             
      Hypertrophy, Focal                   |                      2                 2                                 |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                          1                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 0| 3| 3| 3| 0| 3| 3| 7| 3| 6| 3|             
                                           | 2| 3| 3| 3| 3| 5| 5| 5| 5| 5| 3| 1| 1| 8| 6| 1| 1| 1| 6| 1| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       1                                                  4               |             
      Pars Distalis, Cyst                  |             3              3              3        3                 3   |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                              3  1|             
      Pars Intermedia, Angiectasis         |       2                                                                  |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                            3                                             |             
      C-Cell, Hyperplasia                  |    1  1  1  1  2     2  3  1     1  2                                   1|             
      Follicle, Cyst                       |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2              3   |             
      Cyst                                 |                            4                                      3      |             
      Hyperplasia                          |                                        2        2                        |             
      Inflammation, Chronic                |                               2        3              2              3   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  3              3     3                 3|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                1                 3     3           2                     |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2                    2     3  4                             2         |             
      Infiltration Cellular, Histiocyte    |                                                                   2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 0| 3| 3| 3| 0| 3| 3| 7| 3| 6| 3|             
                                           | 2| 3| 3| 3| 3| 5| 5| 5| 5| 5| 3| 1| 1| 8| 6| 1| 1| 1| 6| 1| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
      Mediastinal, Hemorrhage              |                                                    2                     |             
      Mediastinal, Pigmentation            |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                1         |             
      Hyperplasia, Lymphoid                |                                                       2        3  2      |             
      Pigmentation                         | 2  2  2  2        2        2  2        2  2  2  2  2  2  2  2  2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                1                                                         |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            3                                             |             
      Hematopoietic Cell Proliferation     | 2  2     2  2  1  1  1  3  2     4  2        2  1  1     2  1  4  1     1|             
      Pigmentation                         |    1  3  3  2  2  3  3  1  3        2  2  3  3     2     3  3     2  3  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                              3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   4  2  2     2  2     2  2  2     2  2  2     2  2      |             
      Hyperplasia                          |    3     2  2  2           1  2     4        2  3  3     3  2  3  3      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                      2              3     3  3                           |             
      Femur, Osteopetrosis                 |    2     4     2     2           2  4     3  2                 4         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 0| 3| 3| 3| 0| 3| 3| 7| 3| 6| 3|             
                                           | 2| 3| 3| 3| 3| 5| 5| 5| 5| 5| 3| 1| 1| 8| 6| 1| 1| 1| 6| 1| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   4                                   3           3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2  2  1  1  2  1  1  2  1     2  2  2  1  2  1  2  2  2  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |       1        1                    1                          2  1      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                1         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                3         |             
      Retina, Degeneration                 |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                   2      |             
      Infarct                              |                                                                   1      |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 1  1     1  1  1  1  1  1        1  1  1     1  1  1  1  1        1  1  1|             
      Renal Tubule, Cytoplasmic Alteration |                            1                                             |             
      Renal Tubule, Degeneration, Hyaline  |                                           1                              |             
      Renal Tubule, Pigmentation           |                            1              1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 0| 3| 3| 3| 0| 3| 3| 7| 3| 6| 3|             
                                           | 2| 3| 3| 3| 3| 5| 5| 5| 5| 5| 3| 1| 1| 8| 6| 1| 1| 1| 6| 1| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 8| 3| 3| 3| 0| 0| 3| 3| 0|                                            |            |
                                           | 8| 5| 0| 0| 0| 9| 9| 3| 3| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1250 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      4  2.3|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     60     |
      Clear Cell Focus                     |       X  X              X                                                |     28     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |    X     X     X  X  X  X  X                                             |     25     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                            3                                             |      1  3.0|
      Hepatodiaphragmatic Nodule           |    X        X  X                                                         |     10     |
      Infiltration Cellular, Mixed Cell    |                   3                                                      |      6  1.8|
      Mixed Cell Focus                     |             X                                                            |     11     |
      Necrosis, Focal                      |                                                                          |      3  1.3|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Accessory Spleen                     |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 8| 3| 3| 3| 0| 0| 3| 3| 0|                                            |            |
                                           | 8| 5| 0| 0| 0| 9| 9| 3| 3| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1250 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      7  1.3|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                      2                                                   |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |          3                                                               |      1  3.0|
      Epithelium, Hyperplasia              |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |       1                    2                                             |     13  1.2|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |    3           3  3     3                                                |      8  3.0|
      Degeneration, Fatty                  | 3  2           3        1                                                |     17  2.1|
      Hyperplasia, Focal                   | 3     1           2  3  2                                                |     14  1.9|
      Hypertrophy, Focal                   |                   1                                                      |      6  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 8| 3| 3| 3| 0| 0| 3| 3| 0|                                            |            |
                                           | 8| 5| 0| 0| 0| 9| 9| 3| 3| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1250 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                   2                                                      |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      4  2.3|
      Pars Distalis, Cyst                  |       3     3     3  3  3                                                |     22  3.0|
      Pars Distalis, Hyperplasia, Focal    |             2        2  2                                                |     12  2.3|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |       2  1  1              2                                             |     22  1.4|
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  M  +  +  +  +                                             |  54        |
      Atrophy                              |                            2                                             |      6  2.3|
      Cyst                                 |                                                                          |      4  3.5|
      Hyperplasia                          |       2                                                                  |      4  2.0|
      Inflammation, Chronic                |       3                                                                  |      6  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |          3                                                               |     11  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 8| 3| 3| 3| 0| 0| 3| 3| 0|                                            |            |
                                           | 8| 5| 0| 0| 0| 9| 9| 3| 3| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1250 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                                                                          |      1  2.0|
      Hyperplasia, Cystic                  |                                                                          |      9  2.2|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 2                          3                                             |     15  2.7|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      6  2.2|
      Pigmentation                         |    2  2     2  2                                                         |     30  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      4  1.3|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 1  2  1  1  2  2  1  1  1  2                                             |     48  1.9|
      Pigmentation                         | 1  3  2  3  3  3  1  3  2  1                                             |     43  2.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 8| 3| 3| 3| 0| 0| 3| 3| 0|                                            |            |
                                           | 8| 5| 0| 0| 0| 9| 9| 3| 3| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1250 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |       2              2                                                   |     29  1.9|
      Hyperplasia                          |    4  3     2     2     2  2                                             |     30  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                            3                                             |      1  3.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               |                   2                                                      |      6  2.5|
      Femur, Osteopetrosis                 |                                                                          |     13  2.8|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |    4                                                                     |      5  3.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |          2                                                               |      2  3.0|
      Infiltration Cellular, Histiocyte    |       2  1  1  2  1  1  2  2                                             |     53  1.4|
      Alveolar Epithelium, Hyperplasia     |          3  1        1  3                                                |     16  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 8| 3| 3| 3| 0| 0| 3| 3| 0|                                            |            |
                                           | 8| 5| 0| 0| 0| 9| 9| 3| 3| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1250 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  3.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          |    1  1  1  1  1  1  1  1  1                                             |     48  1.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  1.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      4  1.3|
      Renal Tubule, Pigmentation           |    1                                                                     |      7  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 8| 3| 8| 8| 0| 0| 0| 3| 3| 3| 3| 6| 9| 6| 8| 3| 7| 3| 3| 0| 3| 3| 3| 0| 6|             
                                           | 5| 4| 6| 5| 8| 8| 2| 3| 3| 3| 4| 3| 1| 5| 7| 4| 6| 4| 4| 8| 4| 4| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1  3                 1                                       |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X     X  X        X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X  X     X  X  X  X              X           X     X  X  X        X      |             
      Degeneration, Cystic                 |                                           2                              |             
      Eosinophilic Focus                   |    X     X  X     X     X  X        X     X           X  X  X  X  X  X  X|             
      Hematopoietic Cell Proliferation     |       3                       2                                1         |             
      Hepatodiaphragmatic Nodule           |                   X  X        X           X                              |             
      Infiltration Cellular, Mixed Cell    |                            1        2                    1  2        1   |             
      Mixed Cell Focus                     |    X     X  X  X  X  X                                X  X  X  X         |             
      Necrosis, Focal                      |                1              4        3  2                          1   |             
      Regeneration, Diffuse                |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Accessory Spleen                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                 1                                                      |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  3  2  2  2     2  2  3  2  2     3  3  3     2  3  2  3  2  2  2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 8| 3| 8| 8| 0| 0| 0| 3| 3| 3| 3| 6| 9| 6| 8| 3| 7| 3| 3| 0| 3| 3| 3| 0| 6|             
                                           | 5| 4| 6| 5| 8| 8| 2| 3| 3| 3| 4| 3| 1| 5| 7| 4| 6| 4| 4| 8| 4| 4| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               1     2  2                                 |             
      Ulcer                                |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1           1                       1               |             
      Myocardium, Fibrosis                 |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             3                                                            |             
      Degeneration, Fatty                  |                      3        3  3  2  1                 2              4|             
      Hyperplasia, Diffuse                 |                               3                                          |             
      Hyperplasia, Focal                   |          1           3     2           1                    2  2        4|             
      Hypertrophy, Focal                   |                         4                                2               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     4                                    |             
      Pars Distalis, Cyst                  |       3  3        3     3  3  3  3     3           3  3              3   |             
      Pars Distalis, Hyperplasia, Focal    |          1  1        3     1              1              2  3            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 8| 3| 8| 8| 0| 0| 0| 3| 3| 3| 3| 6| 9| 6| 8| 3| 7| 3| 3| 0| 3| 3| 3| 0| 6|             
                                           | 5| 4| 6| 5| 8| 8| 2| 3| 3| 3| 4| 3| 1| 5| 7| 4| 6| 4| 4| 8| 4| 4| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1        1                                               1|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |    3        3        2     3  3     3        2                 3         |             
      Cyst                                 |                                                       3                  |             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Chronic                |       2              2                                         3         |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    3                 3                                   3               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydrometra                           |                                        3                                 |             
      Hyperplasia, Cystic                  |       1                                      2                           |             
      Epithelium, Hyperplasia              |                                                             3            |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                      +                 +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  3     3     2  2        4  3     3        3        3               |             
      Myelofibrosis                        |                                                                         3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                                                                  |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 8| 3| 8| 8| 0| 0| 0| 3| 3| 3| 3| 6| 9| 6| 8| 3| 7| 3| 3| 0| 3| 3| 3| 0| 6|             
                                           | 5| 4| 6| 5| 8| 8| 2| 3| 3| 3| 4| 3| 1| 5| 7| 4| 6| 4| 4| 8| 4| 4| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Renal, Hemorrhage                    |       3                                                                  |             
      Renal, Pigmentation                  |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia                              |                                                             2            |             
      Hemorrhage                           |          3              1                                   1            |             
      Hyperplasia, Lymphoid                |                3                 2                             3     2   |             
      Pigmentation                         | 2  3  2              2  2  2        2  2     2        2     2     2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1        1           2                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  3  4  2  2  1  2  2     2  4  3     4     2     1  2  3  1  3  2  3   |             
      Pigmentation                         | 2  2  3  2  1  3  1  2     1     2  3  3     3     3  2           3  1   |             
      Lymphoid Follicle, Atrophy           |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2                             1  1  1           1  2     1|             
      Hyperplasia                          | 2  3           1              2           2                              |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |    3  3                    2                          2  2           3   |             
      Femur, Osteopetrosis                 |    3  3                                            2     2     3     3  3|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 8| 3| 8| 8| 0| 0| 0| 3| 3| 3| 3| 6| 9| 6| 8| 3| 7| 3| 3| 0| 3| 3| 3| 0| 6|             
                                           | 5| 4| 6| 5| 8| 8| 2| 3| 3| 3| 4| 3| 1| 5| 7| 4| 6| 4| 4| 8| 4| 4| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3                                                                     |             
      Hydrocephalus                        |    2                                3                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Infiltration Cellular, Histiocyte    | 1  1     2     1     1  1  1  1     1  1  1  1  1  2  1  2  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |          4                                                               |             
      Alveolar Epithelium, Hyperplasia     |    3                             1  1                    2  1  1         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             1                                                            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
      Retina, Degeneration                 |                                                                         4|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
      Nephropathy                          | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|             
      Renal Tubule, Degeneration, Hyaline  |    1                    1           1     3                 1            |             
      Renal Tubule, Pigmentation           |    1                    1           2     3                 1            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 8| 3| 8| 8| 0| 0| 0| 3| 3| 3| 3| 6| 9| 6| 8| 3| 7| 3| 3| 0| 3| 3| 3| 0| 6|             
                                           | 5| 4| 6| 5| 8| 8| 2| 3| 3| 3| 4| 3| 1| 5| 7| 4| 6| 4| 4| 8| 4| 4| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                         3|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 0| 3| 3| 8| 3| 3| 3| 9| 6| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 8| 3| 6| 6| 4| 3| 2| 6| 3| 4| 9| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X  X     X  X  X        X  X  X           X  X     X  X        X  X  X  X|             
      Degeneration, Cystic                 |          1                                                               |             
      Eosinophilic Focus                   | X  X  X     X  X     X     X  X        X     X     X        X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Infiltration Cellular, Mixed Cell    |       2     1                                   2                        |             
      Mixed Cell Focus                     | X  X  X     X  X     X                 X           X        X  X     X  X|             
      Necrosis, Focal                      |                                                                          |             
      Regeneration, Diffuse                |                                                                          |             
      Centrilobular, Necrosis              |                                  3  3                                    |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Accessory Spleen                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Acinus, Hyperplasia, Focal           | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2  3  2  3     2  2  2  2        2  2  2  2     3     2  3  3  3  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 0| 3| 3| 8| 3| 3| 3| 9| 6| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 8| 3| 6| 6| 4| 3| 2| 6| 3| 4| 9| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                2           1  1  1  2        1                           |             
      Myocardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       3                 3  3  3        3           3  3           3      |             
      Degeneration, Fatty                  |       4                       2              1                           |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |    1  3                 1           3              2        3  1  1      |             
      Hypertrophy, Focal                   |                   4           3              1                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           3                                                   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2  2                             3                                       |             
      Pars Distalis, Cyst                  | 3  3                 3  3  3                 3     3  3  3           3   |             
      Pars Distalis, Hyperplasia, Focal    |                                              3           2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 0| 3| 3| 8| 3| 3| 3| 9| 6| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 8| 3| 6| 6| 4| 3| 2| 6| 3| 4| 9| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3                                      1  1  2        1                  |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |    3  2     2  2        2     2        2  3  3              2           3|             
      Cyst                                 |                                                          3               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                           4                              |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          4                                                               |             
      Cyst                                 |                3                       3                                 |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydrometra                           |                                                                      3   |             
      Hyperplasia, Cystic                  |                2           1                                             |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +           +     +     +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  3                       3  3  3     2  4  3     3  2        2  2|             
      Myelofibrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
      Mediastinal, Hemorrhage              |                         4                                                |             
      Mediastinal, Pigmentation            |                         3                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 0| 3| 3| 8| 3| 3| 3| 9| 6| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 8| 3| 6| 6| 4| 3| 2| 6| 3| 4| 9| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         2                       3                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 3  3  3                             3  2     2  4  3        2            |             
      Pigmentation                         | 2  2           2        2  2  3  2  2     2                       2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Pigmentation                         |                                                             3            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3  2  3  1  2     2  2  2  2  3  4  2  2  2  3  2     2  2  1     2  2|             
      Pigmentation                         | 2  1        3  2     1  2  3  3  3  3  1  2     2  2  3  1  2  3  3     2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2  1        2  1  1              3  1  2                 1  1        2|             
      Hyperplasia                          | 1  3  1  2  3           2  2     1     3              2           1  3   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                         3                                                |             
      Femur, Osteopetrosis                 |          2           2  4  2                             3        2      |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 0| 3| 3| 8| 3| 3| 3| 9| 6| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 8| 3| 6| 6| 4| 3| 2| 6| 3| 4| 9| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            2                                             |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  1  1  1  2  1  1  2  2  1  1  1  1  2  1  1  2  2     1  1  2  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       3                                            3                    1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          X     X        X                    X                           |             
      Inflammation, Chronic                |          2     1        2                    1  3  2                     |             
      Respiratory Epithelium, Hyperplasia  |                1                                                         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |       +                                         +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 1  1  1  1  1  1     1  1  1  1           1  1  1  1  1  1  1  1  1     1|             
      Renal Tubule, Degeneration, Hyaline  | 1                          1                 1                 1         |             
      Renal Tubule, Pigmentation           | 1                    1  1  1                 1              1  1     1  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 0| 3| 3| 8| 3| 3| 3| 9| 6| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 8| 3| 6| 6| 4| 3| 2| 6| 3| 4| 9| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2000 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 3| 1| 1| 1| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  I  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                   2                                                      |      4  1.8|
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X                                             |     54     |
      Clear Cell Focus                     |             X  X  X  X  X                                                |     33     |
      Degeneration, Cystic                 |                                                                          |      2  1.5|
      Eosinophilic Focus                   | X     X  X           X     X                                             |     32     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Hepatodiaphragmatic Nodule           |                         X  X                                             |      7     |
      Infiltration Cellular, Mixed Cell    |       2  1        2  2                                                   |     12  1.6|
      Mixed Cell Focus                     | X     X  X     X  X     X                                                |     28     |
      Necrosis, Focal                      |                                                                          |      5  2.2|
      Regeneration, Diffuse                |    4                                                                     |      1  4.0|
      Centrilobular, Necrosis              |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Accessory Spleen                     |          X                                                               |      1     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                   1                                                      |      4  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 3| 1| 1| 1| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Acinus, Hyperplasia, Focal           |             2                                                            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 2  3  3  3  2  2        2                                                |     48  2.4|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      3  1.7|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |       2  2  1     1                                                      |     13  1.3|
      Myocardium, Fibrosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  M  +  +  +  +  +  +                                             |  59        |
      Accessory Adrenal Cortical Nodule    |                   3                                                      |     10  3.0|
      Degeneration, Fatty                  |                         4                                                |     11  2.6|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |     15  2.0|
      Hypertrophy, Focal                   |                      1  3                                                |      7  2.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                            1                                             |      3  1.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 3| 1| 1| 1| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      4  2.8|
      Pars Distalis, Cyst                  |       3        3        3                                                |     24  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      9  1.9|
      Pars Intermedia, Cyst                |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |       1                                                                  |      9  1.3|
      Follicle, Cyst                       |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Atrophy                              | 2  2  3     1           2  1                                             |     25  2.4|
      Cyst                                 |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic                |                         2                                                |      5  2.6|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |    3                                                                     |      2  3.5|
      Cyst                                 |                         3                                                |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |             4                                                            |      1  4.0|
      Hydrometra                           |                         3                                                |      3  3.0|
      Hyperplasia, Cystic                  |          1     2     2  3                                                |      8  1.8|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 3| 1| 1| 1| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |       2              2                                                   |     24  2.7|
      Myelofibrosis                        |    3                                                                     |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    M     +                 +                                             |   4        |
      Mediastinal, Hemorrhage              |          2                 3                                             |      3  3.0|
      Mediastinal, Pigmentation            |          2                 3                                             |      3  2.7|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |       4                                                                  |      4  2.8|
      Hemorrhage                           |                1                                                         |      4  1.5|
      Hyperplasia, Lymphoid                | 2     4                                                                  |     15  2.7|
      Pigmentation                         |          3           2  2  2                                             |     30  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                2           3                                             |      5  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |          2                                                               |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     | 1     1     1  2        1  2                                             |     48  2.1|
      Pigmentation                         | 3     2  3  3  2  3  4  3  2                                             |     46  2.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |       3  3                                                               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 3| 1| 1| 1| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           | 2        1  1     1  1     2                                             |     24  1.4|
      Hyperplasia                          |       3        2                                                         |     19  2.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               |    2  2        3                                                         |     10  2.5|
      Femur, Osteopetrosis                 |    2     3     3                                                         |     16  2.6|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          | 3                                                                        |      3  2.7|
      Hydrocephalus                        |                      2                                                   |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  2  1  1  1  2  1  2                                             |     55  1.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      9  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |       X  X              X                                                |      7     |
      Inflammation, Chronic                |       2  2                                                               |      8  1.9|
      Respiratory Epithelium, Hyperplasia  |          1                                                               |      3  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 3| 1| 1| 1| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2000 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  2  1  1  1  1  1  1                                             |     52  1.0|
      Renal Tubule, Degeneration, Hyaline  |          2           1                                                   |     11  1.3|
      Renal Tubule, Pigmentation           |          2           1  1                                                |     17  1.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 2| 4| 2| 2| 2| 2| 2| 2| 2| 3| 4| 3| 3| 3| 3| 2| 2| 0| 4| 3| 3| 3|             
                                           | 1| 0| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 3| 0| 9| 9| 5| 1| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |    X  X  X     X  X  X  X  X  X  X  X     X        X     X  X  X  X  X  X|             
      Clear Cell Focus                     |          X     X  X     X  X  X  X  X     X  X        X     X     X  X   |             
      Degeneration, Cystic                 |                2                                                         |             
      Eosinophilic Focus                   |                               X              X                           |             
      Hemorrhage                           |                                                                         3|             
      Hepatodiaphragmatic Nodule           | X                          X                                             |             
      Infiltration Cellular, Mixed Cell    |       1                                                                  |             
      Mixed Cell Focus                     |                      X                             X                    X|             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  3  1  2  2  2     2  2  2  2  2  2  1     3  1  3  2  3  2  1  2  2  2|             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic| 3                                      4                                 |             
      Kupffer Cell, Pigmentation           | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +        +        +     +              +                           |             
      Accessory Spleen                     |                X                                                         |             
      Congestion                           |                         3                                                |             
      Fat, Necrosis                        |       3                 2     3              2                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 2| 4| 2| 2| 2| 2| 2| 2| 2| 3| 4| 3| 3| 3| 3| 2| 2| 0| 4| 3| 3| 3|             
                                           | 1| 0| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 3| 0| 9| 9| 5| 1| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Atrophy                              |                                  2  3     2        2                     |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        3        3                        |             
      Ulcer                                |             2                          4                                 |             
      Epithelium, Hyperplasia              |             2                          3        3                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                              2                          1|             
      Infiltration Cellular, Lymphoid      |       3                                                                  |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
      Epithelium, Hyperplasia              |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2     3  3           2  1  1  1     2     1  3  3     2     1      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             3  3              3  3     3              3                 3|             
      Degeneration, Fatty                  | 2  2  1  2     2     1           2        1        1     1              1|             
      Hyperplasia, Focal                   |                1              1  3        2        2              2      |             
      Hypertrophy, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              1           1               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 2| 4| 2| 2| 2| 2| 2| 2| 2| 3| 4| 3| 3| 3| 3| 2| 2| 0| 4| 3| 3| 3|             
                                           | 1| 0| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 3| 0| 9| 9| 5| 1| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Pigmentation                         |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                     3                                   3|             
      Pars Distalis, Cytoplasmic Alteration|                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 1           2        3           2                                2     3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                    1                 2                       2   |             
      Follicle, Cyst                       |    3                                      3                              |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |    2  3  3  3  2  4  2  3     3           3        3  3     2        3   |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                                               2      |             
      Cyst                                 |                                        3                                 |             
      Inflammation, Chronic                | 2  3     2  2           2  2     3        3  2     2  2  2  2     2  2  2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2  2        2  2        2        2  3  2     3              3         |             
      Ventral, Hyperplasia                 |          1     1                          1           2           3  1   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 2| 4| 2| 2| 2| 2| 2| 2| 2| 3| 4| 3| 3| 3| 3| 2| 2| 0| 4| 3| 3| 3|             
                                           | 1| 0| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 3| 0| 9| 9| 5| 1| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Germinal Epithelium, Atrophy         |                   4                    1                       4         |             
      Interstitial Cell, Hyperplasia       |                                        1        1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +           +                                      +                     |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                    3                     |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   3                                                      |             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia, Lymphoid                |                   2                    2                                 |             
      Pigmentation                         |          2                       2                 2  2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                   2     2              2                                 |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2                                3              2     3               |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Pigmentation                         |                                        4        2              3         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        1                       1         |             
      Galactocele                          |       1                                                                  |             
      Hyperplasia                          |                   3                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 2| 4| 2| 2| 2| 2| 2| 2| 2| 3| 4| 3| 3| 3| 3| 2| 2| 0| 4| 3| 3| 3|             
                                           | 1| 0| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 3| 0| 9| 9| 5| 1| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        3        4              3         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                        2        2                        |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Infiltration Cellular, Histiocyte    |    1  1     1                 1        2  1        1                 1   |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X     X                 X                                   X        X   |             
      Inflammation, Chronic                | 1                                                           3        1   |             
      Respiratory Epithelium, Hyperplasia  | 1                                                                    1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                   1                                         3            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 2| 4| 2| 2| 2| 2| 2| 2| 2| 3| 4| 3| 3| 3| 3| 2| 2| 0| 4| 3| 3| 3|             
                                           | 1| 0| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 3| 0| 9| 9| 5| 1| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Atrophy                              |    3                                                                     |             
      Inflammation, Chronic                |    3                                                                     |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1     1  2  1  1  1  1  1  1  3  1  1  1  1  1     1  1  1  1  1|             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |                                                          3               |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 2| 2| 2| 0| 2| 8| 1| 3| 3| 3| 2| 0| 7| 2| 2| 5| 3| 2|             
                                           | 0| 0| 0| 0| 1| 9| 3| 9| 2| 9| 5| 7| 6| 4| 0| 0| 0| 0| 7| 3| 9| 9| 5| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
      Basophilic Focus                     | X  X  X  X           X     X           X  X  X        X     X  X        X|             
      Clear Cell Focus                     | X  X  X  X              X  X              X  X        X                 X|             
      Degeneration, Cystic                 | 1                                                              2         |             
      Eosinophilic Focus                   |                         X     X           X                 X  X         |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                                             |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mixed Cell Focus                     |          X                                                               |             
      Necrosis, Focal                      |                               3                                      4   |             
      Bile Duct, Hyperplasia               | 2  2  2  3  3  3     3  3     2  2  3  1  1  2  3  3  2  3  3  3  3     2|             
      Centrilobular, Necrosis              |                                  2                                       |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                                                       4                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +        +        +     +           +     +        +   |             
      Accessory Spleen                     |                                     X                                    |             
      Congestion                           |                            3                                             |             
      Fat, Necrosis                        |                   3                 3     2           2     2        4   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 2| 2| 2| 0| 2| 8| 1| 3| 3| 3| 2| 0| 7| 2| 2| 5| 3| 2|             
                                           | 0| 0| 0| 0| 1| 9| 3| 9| 2| 9| 5| 7| 6| 4| 0| 0| 0| 0| 7| 3| 9| 9| 5| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Atrophy                              |                            2  1              2              1        1   |             
      Acinus, Hyperplasia, Focal           |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Edema                                |                                     3                                    |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                     2                             1      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                    2                     |             
      Infiltration Cellular, Lymphoid      |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     3  2  2  2  2  1        3     2  1  3  2  2  1     2     2        2|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       3                 3        3                          3           3|             
      Degeneration, Fatty                  |                   1                          2                       2  1|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                         2                    2                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                    1        2                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 2| 2| 2| 0| 2| 8| 1| 3| 3| 3| 2| 0| 7| 2| 2| 5| 3| 2|             
                                           | 0| 0| 0| 0| 1| 9| 3| 9| 2| 9| 5| 7| 6| 4| 0| 0| 0| 0| 7| 3| 9| 9| 5| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |                                           1                              |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3                                                                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic Alteration|                                  3                                       |             
      Pars Distalis, Hyperplasia, Focal    |                                        2           2              1      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                 2                             1              1|             
      Follicle, Cyst                       |                                                                         3|             
      Follicular Cell, Hyperplasia         |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                           +                    +         |             
      Mesothelium, Hyperplasia             |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |    3     3        3  3  3  3  3     2  3  2  3  3  2     3  3  3  3  2   |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2           2                    2  2  2               |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                | 3     3  2  2  3     3  2  2  2           3  2  2     2  2  3  3     2  3|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3     2                             3     3  2  2     3     4        3   |             
      Ventral, Hyperplasia                 | 2     1     4     1        1     1        1  3                           |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 2| 2| 2| 0| 2| 8| 1| 3| 3| 3| 2| 0| 7| 2| 2| 5| 3| 2|             
                                           | 0| 0| 0| 0| 1| 9| 3| 9| 2| 9| 5| 7| 6| 4| 0| 0| 0| 0| 7| 3| 9| 9| 5| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Germinal Epithelium, Atrophy         |             1                 3  4        3              3     4  2      |             
      Interstitial Cell, Hyperplasia       |             1     2           2     1     2                    2  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +  +  +  +  +        +  +           +  +     +        +      |             
      Mediastinal, Hemorrhage              |             2                    4                                       |             
      Mediastinal, Pigmentation            |             2                    2                       3               |             
      Pancreatic, Pigmentation             |                      2                                                   |             
      Renal, Pigmentation                  |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +|             
      Ectasia                              |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                               2                    2     2     2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                  1                                   2   |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                4         |             
      Hematopoietic Cell Proliferation     |                         2        3     4                             4   |             
      Pigmentation                         |    2  2                       3  2        2                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           3                              |             
      Galactocele                          |                                  1                                       |             
      Hyperplasia                          |                3                                   2  1              2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 2| 2| 2| 0| 2| 8| 1| 3| 3| 3| 2| 0| 7| 2| 2| 5| 3| 2|             
                                           | 0| 0| 0| 0| 1| 9| 3| 9| 2| 9| 5| 7| 6| 4| 0| 0| 0| 0| 7| 3| 9| 9| 5| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
      Atrophy                              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                           2           2                  |             
      Hemorrhage                           |                                                                      2   |             
      Hydrocephalus                        |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                         +     +                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                         +     +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                            4   |             
      Infiltration Cellular, Histiocyte    |       1  1        1        1        1  1           1  2  1  1        3   |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  4                          2            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    X                          X              X              X            |             
      Inflammation, Chronic                |    2  2           1                                         1            |             
      Respiratory Epithelium, Hyperplasia  |    2  1     1                                                            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 2| 2| 2| 0| 2| 8| 1| 3| 3| 3| 2| 0| 7| 2| 2| 5| 3| 2|             
                                           | 0| 0| 0| 0| 1| 9| 3| 9| 2| 9| 5| 7| 6| 4| 0| 0| 0| 0| 7| 3| 9| 9| 5| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Retina, Degeneration                 |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  1  1|             
      Renal Tubule, Degeneration, Hyaline  |                                                          1  1            |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |                                                       2  3  1            |             
      Transitional Epithelium, Hyperplasia |                                                             1            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  3.0|
      Basophilic Focus                     |       X  X     X     X  X  X                                             |     38     |
      Clear Cell Focus                     |          X     X     X  X  X                                             |     29     |
      Degeneration, Cystic                 |                                                                          |      3  1.7|
      Eosinophilic Focus                   |                                                                          |      7     |
      Hemorrhage                           |                            2                                             |      2  2.5|
      Hepatodiaphragmatic Nodule           |             X        X                                                   |      5     |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                         X                                                |      5     |
      Necrosis, Focal                      |                   3                                                      |      3  3.3|
      Bile Duct, Hyperplasia               | 4  4  1        2  1  2  2  2                                             |     53  2.2|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|             3     3                                                      |      4  3.3|
      Kupffer Cell, Pigmentation           |    2                    4                                                |      4  3.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +     +           +  +                                             |  16        |
      Accessory Spleen                     |                            X                                             |      3     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Congestion                           |                         3                                                |      3  3.0|
      Fat, Necrosis                        |       3     4           1                                                |     13  2.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |       3           3                                                      |     11  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |    2                                                                     |      4  2.8|
      Ulcer                                |                                                                          |      2  3.0|
      Epithelium, Hyperplasia              |    1                                                                     |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                   3                                                      |      4  2.0|
      Infiltration Cellular, Lymphoid      |                                                                          |      1  3.0|
      Ulcer                                |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1     1     2  2  3  2  2  2                                             |     40  1.9|
      Thrombosis                           |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                   3                                                      |     13  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Degeneration, Fatty                  |       2                                                                  |     16  1.5|
      Hyperplasia, Focal                   |                                                                          |      6  1.8|
      Hypertrophy, Focal                   | 2                                                                        |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 3     2                                                                  |      7  1.6|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 2                                                                        |      2  1.5|
      Pigmentation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |       3                 1                                                |      3  2.3|
      Pars Distalis, Cyst                  |                                                                          |      2  3.0|
      Pars Distalis, Cytoplasmic Alteration|                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                            1                                             |     10  1.9|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |       2     1                                                            |     10  1.5|
      Follicle, Cyst                       |                                                                          |      3  3.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                   +                                                      |   3        |
      Mesothelium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      | 3  2  2  2  2  3     3                                                   |     39  2.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      7  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic                | 2     2     2  2     2     2                                             |     40  2.3|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                | 2     2     4  2        2                                                |     24  2.5|
      Ventral, Hyperplasia                 |       2           1     1  3                                             |     18  1.7|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Germinal Epithelium, Atrophy         |             1        3     4                                             |     13  2.8|
      Interstitial Cell, Hyperplasia       |    1                                                                     |     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |       3           4                                                      |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +           +                                                            |  16        |
      Mediastinal, Hemorrhage              |                                                                          |      2  3.0|
      Mediastinal, Pigmentation            | 4           2                                                            |      6  2.7|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                                                                          |      2  3.0|
      Hemorrhage                           |                1                                                         |      2  2.0|
      Hyperplasia, Lymphoid                |                            3                                             |      3  2.3|
      Pigmentation                         |                2                                                         |      9  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hemorrhage                           |                                                                          |      2  1.5|
      Pigmentation                         |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             | 3                                                                        |      6  2.8|
      Hematopoietic Cell Proliferation     |       2           4                                                      |      7  2.9|
      Pigmentation                         |                            3                                             |      9  2.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Dilatation                           |                                                                          |      3  1.7|
      Galactocele                          |                                                                          |      2  1.0|
      Hyperplasia                          |    2                                                                     |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |             3                                                            |      6  2.8|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      3  2.7|
      Infiltration Cellular, Histiocyte    |          1     1  1  1  1  1                                             |     25  1.2|
      Metaplasia, Osseous                  |             1                                                            |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      9     |
      Inflammation, Chronic                |                         1  1                                             |      9  1.4|
      Respiratory Epithelium, Hyperplasia  |                            1                                             |      6  1.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy                          | 1  1  2  1     1     1  1  1                                             |     56  1.1|
      Renal Tubule, Degeneration, Hyaline  |                   3                                                      |      3  1.7|
      Renal Tubule, Dilatation             |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 2| 2| 4| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 3| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 PPM                                  | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Renal Tubule, Pigmentation           |                   3                                                      |      5  2.4|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 6| 4| 5| 5| 6| 4| 6| 6| 4|             
                             DAY ON TEST   | 1| 1| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2| 0| 3| 2| 5| 8| 2| 6| 6| 1| 7| 1| 3| 6|             
                                           | 5| 6| 0| 0| 0| 0| 9| 9| 2| 7| 9| 9| 0| 6| 1| 6| 4| 8| 7| 7| 5| 1| 6| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |    4                                                                     |             
      Basophilic Focus                     |       X     X  X  X  X        X  X  X              X  X     X            |             
      Clear Cell Focus                     | X     X     X  X  X              X  X  X        X     X  X  X            |             
      Degeneration, Cystic                 |       2                                                                  |             
      Eosinophilic Focus                   |    X  X              X  X     X  X     X                                 |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                                2              1     2         |             
      Hepatodiaphragmatic Nodule           |       X                             X           X     X                  |             
      Infiltration Cellular, Mixed Cell    |       1                             1                       1            |             
      Mixed Cell Focus                     | X              X                 X  X                                    |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2     1  1  1     2  1  3  4  3  3        1  2     2  1  1           3   |             
      Centrilobular, Necrosis              |                                           2                              |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                               +                        |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        | 2                                               3                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                 1  2                 2     1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 6| 4| 5| 5| 6| 4| 6| 6| 4|             
                             DAY ON TEST   | 1| 1| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2| 0| 3| 2| 5| 8| 2| 6| 6| 1| 7| 1| 3| 6|             
                                           | 5| 6| 0| 0| 0| 0| 9| 9| 2| 7| 9| 9| 0| 6| 1| 6| 4| 8| 7| 7| 5| 1| 6| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         2|             
      Ulcer                                |                         3                          3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  1  2  3  3  3  3  1  2  3  3     1  2     3     3  1     1  1  1|             
      Thrombosis                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 3           3     3                             3                        |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2              3                 2                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 6| 4| 5| 5| 6| 4| 6| 6| 4|             
                             DAY ON TEST   | 1| 1| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2| 0| 3| 2| 5| 8| 2| 6| 6| 1| 7| 1| 3| 6|             
                                           | 5| 6| 0| 0| 0| 0| 9| 9| 2| 7| 9| 9| 0| 6| 1| 6| 4| 8| 7| 7| 5| 1| 6| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         3                                3               |             
      Pars Distalis, Hyperplasia, Focal    | 1                 2                    2  1     2  1        3     2      |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1                 1  2        1           1           1  1  1            |             
      Follicle, Cyst                       |                   3           3                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                +  +                 +     +  +     +                     |             
      Mesothelium, Hyperplasia             |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |             +                                                            |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |       3        3  2  3  4  2  2  3  3     3     2              2  2     3|             
      Fibrosis                             |          3              3                                                |             
      Inflammation, Chronic                |                               2                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                       3  2                                             |             
      Cyst                                 |          3                                                               |             
      Hyperplasia                          |                                                       3                  |             
      Inflammation, Chronic                | 3     3  2     2  2     2  2  2     3  2  2  2  3     2  2  3     2  2   |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1     2                    2           2                          3   |             
      Ventral, Hyperplasia                 |             1                                                            |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 6| 4| 5| 5| 6| 4| 6| 6| 4|             
                             DAY ON TEST   | 1| 1| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2| 0| 3| 2| 5| 8| 2| 6| 6| 1| 7| 1| 3| 6|             
                                           | 5| 6| 0| 0| 0| 0| 9| 9| 2| 7| 9| 9| 0| 6| 1| 6| 4| 8| 7| 7| 5| 1| 6| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                   1  4              4  3     4        2  4     2     3   |             
      Interstitial Cell, Hyperplasia       |    1              1  3                 2           1     2  1  2     1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4           2  4              3  4     2  3  3  4  2  4     2   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +                          +  +                          +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                2                          4  3                           |             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Pigmentation                         |                                              2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2  1                    2                          1                     |             
      Pigmentation                         |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 4              3           3  2                                          |             
      Hematopoietic Cell Proliferation     | 2  2     4              2        1     1  4     2  3  2  4     4     3   |             
      Hemorrhage                           |                         2                          4                     |             
      Pigmentation                         |                2  2        3     2                                   3   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  +  M  +  M|             
      Dilatation                           |                   1     1  1        1        1                       2   |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 6| 4| 5| 5| 6| 4| 6| 6| 4|             
                             DAY ON TEST   | 1| 1| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2| 0| 3| 2| 5| 8| 2| 6| 6| 1| 7| 1| 3| 6|             
                                           | 5| 6| 0| 0| 0| 0| 9| 9| 2| 7| 9| 9| 0| 6| 1| 6| 4| 8| 7| 7| 5| 1| 6| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst                                 |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                 +   |             
      Hemorrhage                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      3   |             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +                                                                    +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +                                                                    +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2           1  1  1     2     1  1     1  1  1     1           1     2|             
      Metaplasia, Osseous                  |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |       1     3     2                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    X  X              X     X     X              X     X     X     X      |             
      Inflammation, Chronic                |    3  2              1                                      1     1      |             
      Respiratory Epithelium, Hyperplasia  |       1              1                                1     1            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 6| 4| 5| 5| 6| 4| 6| 6| 4|             
                             DAY ON TEST   | 1| 1| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2| 0| 3| 2| 5| 8| 2| 6| 6| 1| 7| 1| 3| 6|             
                                           | 5| 6| 0| 0| 0| 0| 9| 9| 2| 7| 9| 9| 0| 6| 1| 6| 4| 8| 7| 7| 5| 1| 6| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                         +                                                |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cataract                             |                                           4                              |             
      Retina, Degeneration                 |                                           3                              |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 1  1  1  1  1  2  1  2     1  1  1  1  1  1  1  1  1  2  1  1  1  1  2  1|             
      Renal Tubule, Degeneration, Hyaline  |                                     2              3                     |             
      Renal Tubule, Dilatation             |                                                                      3  2|             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                      1        1           2  2     1                 1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 2| 2| 3| 6| 2| 3| 5| 0| 3| 5| 2| 3| 1| 3| 1| 9| 3| 2| 3| 1| 5| 0|             
                                           | 4| 9| 9| 9| 9| 0| 9| 6| 0| 6| 3| 0| 5| 1| 0| 4| 0| 6| 1| 0| 9| 6| 3| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |       X  X                                X     X           X     X  X  X|             
      Clear Cell Focus                     |       X  X     X        X     X  X        X     X  X  X        X  X     X|             
      Degeneration, Cystic                 |                                                          1              2|             
      Eosinophilic Focus                   |       X  X     X           X        X        X  X           X           X|             
      Fibrosis                             |                                                 3                        |             
      Hematopoietic Cell Proliferation     | 2                                      2                                 |             
      Hepatodiaphragmatic Nodule           |       X                          X           X  X                        |             
      Infiltration Cellular, Mixed Cell    |                                  1                                       |             
      Mixed Cell Focus                     |          X              X                                                |             
      Necrosis, Focal                      |                               1  1                    4        1         |             
      Bile Duct, Hyperplasia               |       1  3  2  3     4           1  1  2  1  3  1  1     3  2  1  2      |             
      Centrilobular, Necrosis              |                                        3              2                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |                                                                3         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2              3     1  1     3                                1        2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 2| 2| 3| 6| 2| 3| 5| 0| 3| 5| 2| 3| 1| 3| 1| 9| 3| 2| 3| 1| 5| 0|             
                                           | 4| 9| 9| 9| 9| 0| 9| 6| 0| 6| 3| 0| 5| 1| 0| 4| 0| 6| 1| 0| 9| 6| 3| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Hyperplasia, Focal           |                         3                          2                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  3  2  3     3     3  3  1  1           2     2  3     2  2  3  1|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       3        3                                         3     3  3  3   |             
      Degeneration, Fatty                  |                      1                    2           2                 2|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                         3|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  I  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 2| 2| 3| 6| 2| 3| 5| 0| 3| 5| 2| 3| 1| 3| 1| 9| 3| 2| 3| 1| 5| 0|             
                                           | 4| 9| 9| 9| 9| 0| 9| 6| 0| 6| 3| 0| 5| 1| 0| 4| 0| 6| 1| 0| 9| 6| 3| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          3                             3                                 |             
      Pars Distalis, Hyperplasia, Focal    |       2                                   1        1        2            |             
      Pars Intermedia, Cyst                |          3                                                               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      3                             1                     |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |          +     +        +  +  +        +     +              +  +  +     +|             
      Mesothelium, Hyperplasia             |                                                             1            |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 2     3     3  3     2  3        3           3  3  2  3  2  4        3   |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2  2  3                          2                  |             
      Cyst                                 |    3                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 3  4  2           2  3  3     2  3  2     3  3        2  2  3  3  2     2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2     2                 2                       3                 3   |             
      Ventral, Hyperplasia                 |                         2                                                |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 2| 2| 3| 6| 2| 3| 5| 0| 3| 5| 2| 3| 1| 3| 1| 9| 3| 2| 3| 1| 5| 0|             
                                           | 4| 9| 9| 9| 9| 0| 9| 6| 0| 6| 3| 0| 5| 1| 0| 4| 0| 6| 1| 0| 9| 6| 3| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |    2           3  2        4           4              3     4  4         |             
      Interstitial Cell, Hyperplasia       | 1  2                                                  2        2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3        2              3  4        4        2  1     2     3         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +     +     +                 +     +                           |             
      Mediastinal, Hemorrhage              |                                        2                                 |             
      Mediastinal, Pigmentation            |          3     3                       3                                 |             
      Pancreatic, Pigmentation             |          3                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     1                                    |             
      Hyperplasia, Lymphoid                | 3                                2              3                        |             
      Pigmentation                         |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                4     3                                                   |             
      Hematopoietic Cell Proliferation     | 4  3  2     3           2  3  3  2     3  1        1  4  3     2  2  2   |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Dilatation                           |                                  2                                       |             
      Hyperplasia                          |       2                                                              1   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 2| 2| 3| 6| 2| 3| 5| 0| 3| 5| 2| 3| 1| 3| 1| 9| 3| 2| 3| 1| 5| 0|             
                                           | 4| 9| 9| 9| 9| 0| 9| 6| 0| 6| 3| 0| 5| 1| 0| 4| 0| 6| 1| 0| 9| 6| 3| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                2                                                         |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                   +  +                                         +         |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      3   |             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                                                             2            |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                   +                                                      |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Infiltration Cellular, Histiocyte    | 1  1     1  1  1  1  2  1  1     2  1  2  1  3     1     1  1  1  1  2  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      4           3           3                           |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                 X     X  X               |             
      Inflammation, Chronic                |                                        1        3     2                  |             
      Respiratory Epithelium, Hyperplasia  |                                                 2                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 2| 2| 3| 6| 2| 3| 5| 0| 3| 5| 2| 3| 1| 3| 1| 9| 3| 2| 3| 1| 5| 0|             
                                           | 4| 9| 9| 9| 9| 0| 9| 6| 0| 6| 3| 0| 5| 1| 0| 4| 0| 6| 1| 0| 9| 6| 3| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                   +                                                      |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +                                                                 +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                         2                                                |             
      Nephropathy                          | 1  1  1  1  1  2  1  1  1  1  1  2  1  1  1  1  1  1  2  2  1  1  1  3  1|             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Dilatation             |                                                       2                  |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                               2  1     3                                 |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                2     2                                                   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                                                                          |      1  4.0|
      Basophilic Focus                     | X                    X     X                                             |     22     |
      Clear Cell Focus                     | X        X     X     X                                                   |     29     |
      Degeneration, Cystic                 |                                                                          |      3  1.7|
      Eosinophilic Focus                   |    X           X                                                         |     18     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      6  1.8|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Infiltration Cellular, Mixed Cell    |                2                                                         |      5  1.2|
      Mixed Cell Focus                     |    X                                                                     |      7     |
      Necrosis, Focal                      |                                                                          |      4  1.8|
      Bile Duct, Hyperplasia               |    3     1     3     2     2                                             |     37  2.0|
      Centrilobular, Necrosis              |                                                                          |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                3  4                                                      |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +     +     +                                                      |   6        |
      Hemorrhage                           |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 1        3                                                               |     14  1.8|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |             2                                                            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |       3           3                                                      |      2  3.0|
      Ulcer                                |       4           4                                                      |      2  4.0|
      Epithelium, Hyperplasia              |       3           3                                                      |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |             2                                                            |      2  2.0|
      Ulcer                                |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2     3        2  3  3  3                                                |     43  2.2|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                3           3                                             |     12  3.0|
      Degeneration, Fatty                  |    3  3  3  3     3     3                                                |     10  2.5|
      Hyperplasia, Focal                   |                         2  2                                             |      2  2.0|
      Hypertrophy, Focal                   |    3                                                                     |      2  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Cyst                  |                3  3                                                      |      6  3.0|
      Pars Distalis, Hyperplasia, Focal    | 1                                                                        |     13  1.6|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |          3                                                               |      1  3.0|
      C-Cell, Hyperplasia                  |                   1                                                      |     11  1.3|
      Follicle, Cyst                       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +     +        +                                                      |  21        |
      Mesothelium, Hyperplasia             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      | 3           3  3        2                                                |     32  2.7|
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |    3                 2                                                   |      9  2.3|
      Cyst                                 |    3                       3                                             |      4  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                | 2  2     2  2  2  3  2  2                                                |     43  2.4|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |    2  3                    3                                             |     14  2.3|
      Ventral, Hyperplasia                 | 2                                                                        |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Germinal Epithelium, Atrophy         |          4     3  4     3                                                |     21  3.2|
      Interstitial Cell, Hyperplasia       |                         2                                                |     14  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 3        4  4                                                            |     25  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +     +     +  +  +                                                |  14        |
      Mediastinal, Hemorrhage              |             1        2                                                   |      3  1.7|
      Mediastinal, Pigmentation            |             3     3  4                                                   |      9  3.1|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.5|
      Pigmentation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |    3        1                                                            |      6  1.7|
      Pigmentation                         |                            2                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      6  3.2|
      Hematopoietic Cell Proliferation     | 2        3  3           3                                                |     33  2.6|
      Hemorrhage                           |                                                                          |      2  3.0|
      Pigmentation                         |             2              4                                             |      8  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  M  +  +  +  +                                             |  54        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +                                             |  47        |
      Dilatation                           |       2     1              3                                             |     10  1.5|
      Hyperplasia                          |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   5        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                            3                                             |      3  3.0|
      Gliosis                              |                2                                                         |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1  1     1     1     2  1  1                                             |     42  1.3|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |          2              1                                                |      8  2.4|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |          X                                                               |     13     |
      Inflammation, Chronic                |          1                                                               |      9  1.7|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      5  1.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 3| 7| 4| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 8| 7| 2| 9| 0| 8| 4|                                            |            |
                                           | 9| 8| 6| 4| 8| 9| 9| 7| 9| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  3  1  1  2  1  1  1  1                                             |     59  1.2|
      Renal Tubule, Degeneration, Hyaline  |             2                                                            |      3  2.3|
      Renal Tubule, Dilatation             |                                                                          |      3  2.3|
      Renal Tubule, Necrosis               |       3                                                                  |      1  3.0|
      Renal Tubule, Pigmentation           |    3  1           3                                                      |     12  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 3| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 7| 6| 6| 7| 5| 6| 6|             
                             DAY ON TEST   | 9| 2| 1| 7| 3| 3| 8| 9| 8| 9| 5| 1| 1| 8| 5| 8| 3| 5| 1| 1| 0| 0| 1| 5| 3|             
                                           | 7| 7| 4| 3| 6| 7| 5| 1| 1| 1| 8| 5| 4| 5| 6| 5| 0| 6| 4| 6| 3| 6| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3  2                                                            |             
      Atrophy                              |                            4                                             |             
      Basophilic Focus                     | X     X                             X  X        X        X              X|             
      Clear Cell Focus                     |       X  X        X  X  X                 X  X  X     X        X  X     X|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   | X     X     X  X              X  X  X           X  X  X        X     X   |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hemorrhage                           | 4                                                                        |             
      Hepatodiaphragmatic Nodule           |                X                             X                           |             
      Infiltration Cellular, Mixed Cell    |    2                    2           1     2              1               |             
      Mixed Cell Focus                     |             X  X                 X                    X        X         |             
      Necrosis, Focal                      | 3                 1                                         4  2         |             
      Bile Duct, Hyperplasia               |                            2           2           1                     |             
      Centrilobular, Necrosis              |                3              1  1     2                          3  1   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                          3               |             
      Kupffer Cell, Pigmentation           |                            4                                             |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +                       +     +               |             
      Fat, Necrosis                        |                            3                       3     3               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Hyperplasia                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 3| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 7| 6| 6| 7| 5| 6| 6|             
                             DAY ON TEST   | 9| 2| 1| 7| 3| 3| 8| 9| 8| 9| 5| 1| 1| 8| 5| 8| 3| 5| 1| 1| 0| 0| 1| 5| 3|             
                                           | 7| 7| 4| 3| 6| 7| 5| 1| 1| 1| 8| 5| 4| 5| 6| 5| 0| 6| 4| 6| 3| 6| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           1                              |             
      Acinus, Hyperplasia, Focal           |                                  3  3                                    |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3     2                    2        2              2     3  2         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                             2            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    3        3                          3                          3      |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  3  3  3  1     1  2  2  1  3  3  2  2  2  1        2  3  1      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                3                    3           3           3           3|             
      Degeneration, Fatty                  |                            3  1              1  2  1           2        3|             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                                                 2              3         |             
      Hypertrophy, Focal                   |                                                                         3|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 3| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 7| 6| 6| 7| 5| 6| 6|             
                             DAY ON TEST   | 9| 2| 1| 7| 3| 3| 8| 9| 8| 9| 5| 1| 1| 8| 5| 8| 3| 5| 1| 1| 0| 0| 1| 5| 3|             
                                           | 7| 7| 4| 3| 6| 7| 5| 1| 1| 1| 8| 5| 4| 5| 6| 5| 0| 6| 4| 6| 3| 6| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Angiectasis           |    2                       2                          2  1  3            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic Alteration|                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    1  3        3           3           3           1  3              1  2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   3     3                                                |             
      C-Cell, Hyperplasia                  |          2        1              3              1              3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                +  +     +     +     +  +  +  +  +           +     +  +  +|             
      Mesothelium, Hyperplasia             |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |    2           2           3     3  3        2        2  3  2  3  2     3|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              | 2  1  2  3  3  2  2     2  2  3  2        2  2     2  2  2  2        3  3|             
      Cyst                                 |                                                       3                  |             
      Inflammation, Chronic                |       3  2     2  2  3  2     3  3  3     2     2  2  3  3  3           2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3     4        2  2  2     3  2     2                                 |             
      Ventral, Hyperplasia                 |       2  1                 1                    1     3                  |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |             3           2                       4  4        3            |             
      Interstitial Cell, Hyperplasia       |             1           2                                   2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 3| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 7| 6| 6| 7| 5| 6| 6|             
                             DAY ON TEST   | 9| 2| 1| 7| 3| 3| 8| 9| 8| 9| 5| 1| 1| 8| 5| 8| 3| 5| 1| 1| 0| 0| 1| 5| 3|             
                                           | 7| 7| 4| 3| 6| 7| 5| 1| 1| 1| 8| 5| 4| 5| 6| 5| 0| 6| 4| 6| 3| 6| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     2  4  3  3  2  3     4  3  4  2  3  4  2  4  4     3     3  3  3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +              +                                          |             
      Mediastinal, Hemorrhage              |                               1                                          |             
      Mediastinal, Pigmentation            |                4              3                                          |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Lymphoid                |                      2                                      2            |             
      Pigmentation                         |                                                 3        2        2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Hemorrhage                           |                                                       1     2            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               3                 4        3              3|             
      Hematopoietic Cell Proliferation     | 1  2  1  3     3  2  2     4  3  4     4  3     3  4  1  3        4  2   |             
      Pigmentation                         |    2  2     3        2                                   3  2        3   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  M  M  M  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 3| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 7| 6| 6| 7| 5| 6| 6|             
                             DAY ON TEST   | 9| 2| 1| 7| 3| 3| 8| 9| 8| 9| 5| 1| 1| 8| 5| 8| 3| 5| 1| 1| 0| 0| 1| 5| 3|             
                                           | 7| 7| 4| 3| 6| 7| 5| 1| 1| 1| 8| 5| 4| 5| 6| 5| 0| 6| 4| 6| 3| 6| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      4                                                   |             
      Hydrocephalus                        |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1  1  1  2  1        1     1  1  1     2  2  1  1  1  1        2  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       X  X                    X     X                                   X|             
      Inflammation, Chronic                |       3  1                          2                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |       2  2                          1                                    |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 3| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 7| 6| 6| 7| 5| 6| 6|             
                             DAY ON TEST   | 9| 2| 1| 7| 3| 3| 8| 9| 8| 9| 5| 1| 1| 8| 5| 8| 3| 5| 1| 1| 0| 0| 1| 5| 3|             
                                           | 7| 7| 4| 3| 6| 7| 5| 1| 1| 1| 8| 5| 4| 5| 6| 5| 0| 6| 4| 6| 3| 6| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                3         |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  3  1  3        1  1  1  1  1  1  1  3  1  1  1     1  1  1  1  1  1  1|             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |    1  2        3  1        1           3     1              1            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                | 2                                                                        |             
      Transitional Epithelium, Hyperplasia |                                                          1               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 6| 5| 6| 6| 4| 5| 4| 3| 5| 5| 7| 4| 7| 5| 5| 4| 6| 6| 5| 6| 5|             
                             DAY ON TEST   | 2| 2| 6| 6| 3| 0| 3| 9| 8| 6| 3| 8| 0| 7| 2| 8| 1| 8| 3| 8| 1| 7| 1| 5| 1|             
                                           | 8| 9| 4| 7| 2| 2| 7| 1| 3| 9| 2| 4| 2| 6| 9| 3| 4| 1| 1| 3| 6| 6| 9| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |    X           X  X  X     X        X     X     X        X  X            |             
      Clear Cell Focus                     |    X              X  X  X     X        X     X  X  X  X  X  X     X  X  X|             
      Degeneration, Cystic                 |                                           1                              |             
      Eosinophilic Focus                   | X           X        X     X  X     X  X  X     X  X     X  X            |             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hemorrhage                           |                                                    3                     |             
      Hepatodiaphragmatic Nodule           |                                     X              X     X               |             
      Infiltration Cellular, Mixed Cell    | 2              1                    2                             2     1|             
      Mixed Cell Focus                     |    X     X  X              X                                X            |             
      Necrosis, Focal                      |                                                    4                     |             
      Bile Duct, Hyperplasia               |                                           1                    2  1      |             
      Centrilobular, Necrosis              |       2                    2                                             |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                   +      |             
      Hyperplasia                          |                                                                   3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 6| 5| 6| 6| 4| 5| 4| 3| 5| 5| 7| 4| 7| 5| 5| 4| 6| 6| 5| 6| 5|             
                             DAY ON TEST   | 2| 2| 6| 6| 3| 0| 3| 9| 8| 6| 3| 8| 0| 7| 2| 8| 1| 8| 3| 8| 1| 7| 1| 5| 1|             
                                           | 8| 9| 4| 7| 2| 2| 7| 1| 3| 9| 2| 4| 2| 6| 9| 3| 4| 1| 1| 3| 6| 6| 9| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1        4                          2           1                     |             
      Acinus, Hyperplasia, Focal           |                                              1                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2           2     2              2        2  2           2     2   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                2         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1                             2     3                              |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3     3  1  1  3     3  1  3  2     2  3  2  3  1  2  2  2  1        2|             
      Thrombosis                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                           3           3     3        3   |             
      Degeneration, Fatty                  |          1        2                             2                 2      |             
      Hyperplasia, Diffuse                 | 3                                                                        |             
      Hyperplasia, Focal                   |                   2  2              1           2                        |             
      Hypertrophy, Focal                   |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 6| 5| 6| 6| 4| 5| 4| 3| 5| 5| 7| 4| 7| 5| 5| 4| 6| 6| 5| 6| 5|             
                             DAY ON TEST   | 2| 2| 6| 6| 3| 0| 3| 9| 8| 6| 3| 8| 0| 7| 2| 8| 1| 8| 3| 8| 1| 7| 1| 5| 1|             
                                           | 8| 9| 4| 7| 2| 2| 7| 1| 3| 9| 2| 4| 2| 6| 9| 3| 4| 1| 1| 3| 6| 6| 9| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2           2                                                         |             
      Pars Distalis, Cyst                  | 3                    3     1                                             |             
      Pars Distalis, Cytoplasmic Alteration|                                                             1            |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
      Pars Intermedia, Cyst                |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      2           1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |    +     +  +     +  +     +  +     +  +     +     +  +  +     +  +  +  +|             
      Mesothelium, Hyperplasia             |    1                                               1                    2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 2  3  2  2                       2        2     2        2  2  3  3     3|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2  3     3        2     2     2  3  2  3        2           3     2   |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                | 3     2  2     3     2     3  2  2  2  2     3     2  3              2  2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2        3                                2           2  2        2      |             
      Ventral, Hyperplasia                 |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                   4                 4  2        2              2     4   |             
      Interstitial Cell, Hyperplasia       |          1     1              1  1  1  3     1        2                 1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 6| 5| 6| 6| 4| 5| 4| 3| 5| 5| 7| 4| 7| 5| 5| 4| 6| 6| 5| 6| 5|             
                             DAY ON TEST   | 2| 2| 6| 6| 3| 0| 3| 9| 8| 6| 3| 8| 0| 7| 2| 8| 1| 8| 3| 8| 1| 7| 1| 5| 1|             
                                           | 8| 9| 4| 7| 2| 2| 7| 1| 3| 9| 2| 4| 2| 6| 9| 3| 4| 1| 1| 3| 6| 6| 9| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3  2  3     3     3  3  2  4     2  2  3     2  1  3  3        4   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                2         |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                         2                 2                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                                                        |             
      Hemorrhage                           |    1                                                                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             2                                   4        3               |             
      Hematopoietic Cell Proliferation     | 1  3  4  2  2           3  3  2  3     2     2     1     2  3        4  1|             
      Pigmentation                         |                                     3     3     3                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +|             
      Dilatation                           |                                                                3         |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                                                     |             
      Subcutaneous Tissue, Edema           |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 6| 5| 6| 6| 4| 5| 4| 3| 5| 5| 7| 4| 7| 5| 5| 4| 6| 6| 5| 6| 5|             
                             DAY ON TEST   | 2| 2| 6| 6| 3| 0| 3| 9| 8| 6| 3| 8| 0| 7| 2| 8| 1| 8| 3| 8| 1| 7| 1| 5| 1|             
                                           | 8| 9| 4| 7| 2| 2| 7| 1| 3| 9| 2| 4| 2| 6| 9| 3| 4| 1| 1| 3| 6| 6| 9| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                   +  +                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                           2                              |             
      Hydrocephalus                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2        1  1  1  1  1              1     1  1  2     1  1  1  1  1  3  1|             
      Metaplasia, Osseous                  |          2                                                               |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      X                 X        X                    X   |             
      Inflammation, Chronic                | 1                    3                 1        3                    2   |             
      Inflammation, Suppurative            |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 1                    2                 2                             2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Cataract                             |                                                    3                     |             
      Retina, Degeneration                 |                                                    4                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 6| 5| 6| 6| 4| 5| 4| 3| 5| 5| 7| 4| 7| 5| 5| 4| 6| 6| 5| 6| 5|             
                             DAY ON TEST   | 2| 2| 6| 6| 3| 0| 3| 9| 8| 6| 3| 8| 0| 7| 2| 8| 1| 8| 3| 8| 1| 7| 1| 5| 1|             
                                           | 8| 9| 4| 7| 2| 2| 7| 1| 3| 9| 2| 4| 2| 6| 9| 3| 4| 1| 1| 3| 6| 6| 9| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                4                                                         |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Renal Tubule, Necrosis               |                                                                2         |             
      Renal Tubule, Pigmentation           |    1        2        1     3           1  1                              |             
      Transitional Epithelium, Hyperplasia |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       4                                                                  |             
      Inflammation, Chronic                |    3                                                                     |             
      Transitional Epithelium, Hyperplasia |    3                                                                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.5|
      Atrophy                              |                                                                          |      1  4.0|
      Basophilic Focus                     |       X  X           X  X                                                |     21     |
      Clear Cell Focus                     | X     X  X  X        X  X  X                                             |     34     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   | X     X              X  X  X                                             |     29     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      2  3.5|
      Hepatodiaphragmatic Nodule           | X     X                 X                                                |      8     |
      Infiltration Cellular, Mixed Cell    |       1                                                                  |     11  1.5|
      Mixed Cell Focus                     |                         X  X                                             |     12     |
      Necrosis, Focal                      |    3                                                                     |      6  2.8|
      Bile Duct, Hyperplasia               |                      1                                                   |      7  1.4|
      Centrilobular, Necrosis              |                                                                          |      8  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        | 3                                                                        |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    2     1                                                               |      7  1.7|
      Acinus, Hyperplasia, Focal           |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                            2                                             |     18  2.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      7  2.6|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  1     2  1        2     1                                             |     43  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | 3                    3  3  3                                             |     13  3.0|
      Degeneration, Fatty                  |                                                                          |     11  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      6  2.0|
      Hypertrophy, Focal                   |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                      1                                                   |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Pars Distalis, Angiectasis           |                                                                          |      7  2.0|
      Pars Distalis, Cyst                  |                                                                          |      3  2.3|
      Pars Distalis, Cytoplasmic Alteration|                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |       1                 1  2                                             |     13  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      2  3.0|
      C-Cell, Hyperplasia                  |    2                    2                                                |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |       +  +              +                                                |  33        |
      Mesothelium, Hyperplasia             |                                                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Atypia Cellular                      |       3  2                 3                                             |     27  2.4|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 2     3              2                                                   |     35  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic                | 3     2  2           3     3                                             |     36  2.4|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |    3  2  1     2                                                         |     18  2.3|
      Ventral, Hyperplasia                 | 2     2  2                                                               |      9  1.8|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Germinal Epithelium, Atrophy         |                         4                                                |     12  3.2|
      Interstitial Cell, Hyperplasia       |                      2                                                   |     13  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 3  2  2  3              4                                                |     43  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                         +                                                |   4        |
      Mediastinal, Hemorrhage              |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                                                                          |      3  3.0|
      Renal, Ectasia                       |                         3                                                |      1  3.0|
      Renal, Pigmentation                  |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                         3                                                |      3  2.3|
      Pigmentation                         | 2                                                                        |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Fibrosis                             | 2                       3                                                |      9  3.0|
      Hematopoietic Cell Proliferation     | 1  1     1              2                                                |     38  2.4|
      Pigmentation                         | 2           3  3                                                         |     13  2.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  +  +  +  +  +                                             |  46        |
      Dilatation                           |                                                                          |      1  3.0|
      Hyperplasia                          |    4                    1                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                      1                                                   |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1              1                                                |     40  1.2|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                X                                                         |     10     |
      Inflammation, Chronic                |                                                                          |      8  2.0|
      Inflammation, Suppurative            |                4  2                                                      |      2  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      7  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                         3                                                |      3  3.3|
      Mineralization                       |                            1                                             |      1  1.0|
      Nephropathy                          | 1  1  1  1  1  1     1  1  1                                             |     56  1.1|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |     14  1.6|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 2| 2| 2| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 2| 9| 1| 9| 9| 9| 8| 9| 2|                                            |            |
                                           | 7| 1| 1| 2| 8| 9| 9| 9| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 4| 5| 5| 5| 5| 6| 5| 5| 6| 4| 6| 4| 3| 5| 4| 5| 4| 5| 4| 4| 4|             
                             DAY ON TEST   | 3| 6| 4| 1| 0| 0| 3| 8| 4| 3| 4| 8| 5| 7| 0| 9| 9| 6| 6| 4| 1| 2| 1| 0| 7|             
                                           | 9| 9| 0| 9| 4| 2| 4| 9| 4| 2| 4| 6| 6| 9| 3| 5| 6| 7| 4| 4| 9| 3| 9| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2000 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                             3            |             
      Basophilic Focus                     |    X  X  X  X  X  X     X                 X                 X  X  X  X   |             
      Clear Cell Focus                     |       X  X     X  X  X     X  X        X     X           X     X  X  X  X|             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                2           1                                             |             
      Eosinophilic Focus                   |                   X        X  X     X     X  X     X  X  X     X     X   |             
      Hematopoietic Cell Proliferation     |    1                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                         X                                      X         |             
      Infiltration Cellular, Mixed Cell    |          2  2     1  3  1  3     2                       2     1         |             
      Mixed Cell Focus                     |    X     X                                X                    X         |             
      Necrosis, Focal                      |                      1     2                                             |             
      Centrilobular, Necrosis              |                      2                 1        1                        |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                             3            |             
      Kupffer Cell, Pigmentation           |                                                             4            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Accessory Spleen                     |                                                                      X   |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 4| 5| 5| 5| 5| 6| 5| 5| 6| 4| 6| 4| 3| 5| 4| 5| 4| 5| 4| 4| 4|             
                             DAY ON TEST   | 3| 6| 4| 1| 0| 0| 3| 8| 4| 3| 4| 8| 5| 7| 0| 9| 9| 6| 6| 4| 1| 2| 1| 0| 7|             
                                           | 9| 9| 0| 9| 4| 2| 4| 9| 4| 2| 4| 6| 6| 9| 3| 5| 6| 7| 4| 4| 9| 3| 9| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2000 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                2                                   1   |             
      Acinus, Hyperplasia, Focal           |                   2                 2        2                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     2        3  2  3  2  2  2  2  2        2  2  2  3  2  2  2     2  2|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2                                                   |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
      Erosion                              |                      3                 2                                 |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Malformation                         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2        2        2     1  2  2  1  1  2  1  2  3  2     1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 3                 3  3        3     3     3                             3|             
      Degeneration, Fatty                  |                                     1                                    |             
      Hyperplasia, Diffuse                 | 3                                                                        |             
      Hyperplasia, Focal                   |                                           1                          2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 4| 5| 5| 5| 5| 6| 5| 5| 6| 4| 6| 4| 3| 5| 4| 5| 4| 5| 4| 4| 4|             
                             DAY ON TEST   | 3| 6| 4| 1| 0| 0| 3| 8| 4| 3| 4| 8| 5| 7| 0| 9| 9| 6| 6| 4| 1| 2| 1| 0| 7|             
                                           | 9| 9| 0| 9| 4| 2| 4| 9| 4| 2| 4| 6| 6| 9| 3| 5| 6| 7| 4| 4| 9| 3| 9| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2000 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                       2                                       |             
      Pigmentation                         |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                           2                              |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic Alteration|                                                          2           1   |             
      Pars Distalis, Hyperplasia, Focal    |                            2  1                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       2  3  1           2                                   1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +           +  +  +  +        +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                         3  2  2                          4           2   |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3     3     3     3  3  3  2  2     3  2        3  3  2     2     1   |             
      Inflammation, Chronic                |    3  2  2        2              3        2           2  2     2  2     2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                       2                 3                  |             
      Ventral, Hyperplasia                 |          1                                                               |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             4                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 133                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 4| 5| 5| 5| 5| 6| 5| 5| 6| 4| 6| 4| 3| 5| 4| 5| 4| 5| 4| 4| 4|             
                             DAY ON TEST   | 3| 6| 4| 1| 0| 0| 3| 8| 4| 3| 4| 8| 5| 7| 0| 9| 9| 6| 6| 4| 1| 2| 1| 0| 7|             
                                           | 9| 9| 0| 9| 4| 2| 4| 9| 4| 2| 4| 6| 6| 9| 3| 5| 6| 7| 4| 4| 9| 3| 9| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2000 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Germinal Epithelium, Atrophy         |       4        4        1           4  4     3           4               |             
      Interstitial Cell, Hyperplasia       | 1     1  1  1     2     1     2     2        2           2  1     2     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  3     2  3  1  2  3  4  2  2  3  4  3  4  3  3  3        2     3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +                    +     +                                       |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Atrophy                 |                                                                          |             
      Mediastinal, Hemorrhage              |       1                                                                  |             
      Mediastinal, Pigmentation            |    4  3                    4     4                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Pigmentation                         |                2  3           2           2                    2  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                3         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         1           3     3                              |             
      Hematopoietic Cell Proliferation     | 4  2  2     2  2  2  4  2  2  3  1  2  3     3  2  2  2     2  2  1  2  3|             
      Pigmentation                         |                         2                 3     3        2  2            |             
      Capsule, Fibrosis                    |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                   2      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 134                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:33:33    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 4| 5| 5| 5| 5| 6| 5| 5| 6| 4| 6| 4| 3| 5| 4| 5| 4| 5| 4| 4| 4|             
                             DAY ON TEST   | 3| 6| 4| 1| 0| 0| 3| 8| 4| 3| 4| 8| 5| 7| 0| 9| 9| 6| 6| 4| 1| 2| 1| 0| 7|             
                                           | 9| 9| 0| 9| 4| 2| 4| 9| 4| 2| 4| 6| 6| 9| 3| 5| 6| 7| 4| 4| 9| 3| 9| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2000 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain