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TDMS Study 05203-08 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:36:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                     RATS, FINAL#1; CORE STUDY                                                      
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 002    0 PPM                                                                         
                                       INCLUDE 003    625 PPM                                                                       
                                       INCLUDE 004    625 PPM                                                                       
                                       INCLUDE 005    1250 PPM                                                                      
                                       INCLUDE 006    1250 PPM                                                                      
                                       INCLUDE 007    2000 PPM                                                                      
                                       INCLUDE 008    2000 PPM                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:36:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  O-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
                                       Degeneration Fatty                                                                           
                                       Hyperplasia Diffuse                                                                          
                                       Hyperplasia Focal                                                                            
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Bone: Cranium                          Osteopetrosis                                                                                
Brain                                  Compression                                                                                  
Epididymis                             Atypia Cellular                                                                              
Eye                                    Cataract                                                                                     
Eye: Retina                            Degeneration                                                                                 
Heart                                  Cardiomyopathy                                                                               
Islets, Pancreatic                     Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Kidney                                 Cyst                                                                                         
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Degeneration Hyaline                                                                         
                                       Pigmentation                                                                                 
Liver                                  Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hemorrhage                                                                                   
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
                                       Necrosis Focal                                                                               
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Necrosis                                                                                     
Liver: Kupffer Cell                    Pigmentation                                                                                 
Lung                                   Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
                                       Pigmentation                                                                                 
Lymph Node, Mediastinal                Pigmentation                                                                                 
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
                                       Pigmentation                                                                                 
Mammary Gland                          Dilatation                                                                                   
Mesentery                              Accessory Spleen                                                                             
Nose                                   Foreign Body                                                                                 
                                       Inflammation Chronic                                                                         
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Pancreas                               Atrophy                                                                                      
Pancreas: Acinus                       Hyperplasia Focal                                                                            
Peritoneum: Mesothelium                Hyperplasia                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:36:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
Pituitary Gland: Pars Distalis         Angiectasis                                                                                  
                                       Cyst                                                                                         
                                       Cytoplasmic Alteration                                                                       
                                       Hyperplasia Focal                                                                            
Pituitary Gland: Pars Intermedia       Cyst                                                                                         
Preputial Gland                        Atrophy                                                                                      
                                       Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Prostate: Ventral                      Hyperplasia                                                                                  
Salivary Glands                        Atrophy                                                                                      
Spleen                                 Fibrosis                                                                                     
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Edema                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Erosion                                                                                      
                                       Ulcer                                                                                        
Testes                                 Angiectasis                                                                                  
Testes: Germinal Epithelium            Atrophy                                                                                      
Testes: Interstitial Cell              Hyperplasia                                                                                  
Thyroid Gland                          Ultimobranchial Cyst                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicle                Cyst                                                                                         
Urinary Bladder                        Fibrosis                                                                                     
                                       Inflammation Chronic                                                                         
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Hyperplasia Focal                                                                            
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Bone: Cranium                          Osteopetrosis                                                                                
Bone: Femur                            Osteopetrosis                                                                                
Clitoral Gland                         Atrophy                                                                                      
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
                                       Necrosis Focal                                                                               
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Liver: Kupffer Cell                    Pigmentation                                                                                 
Lung                                   Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
Mammary Gland                          Dilatation                                                                                   
                                       Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:36:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
Nose                                   Foreign Body                                                                                 
                                       Inflammation Chronic                                                                         
Ovary                                  Angiectasis                                                                                  
Pancreas                               Atrophy                                                                                      
Salivary Glands                        Atrophy                                                                                      
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Uterus                                 Hydrometra                                                                                   
===============================================================                                                                     
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   O-NITROTOLUENE 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/60 (22%)  12/60 (20%)  13/60 (22%)  10/60 (17%) |8/60 (13%)   10/60 (17%)  8/60 (13%)   10/59 (17%)  | 
|POLY-3 RATE (b)    |     13/54.52     12/45.64     13/39.21     10/27.12    |8/57.34      10/55.69     8/54.16      10/52.97     | 
|POLY-3 PERCENT (g) |     23.8%        26.3%        33.2%        36.9%       |14.0%        18.0%        14.8%        18.9%        | 
|TERMINAL (d)       |     9/39 (23%)   6/18 (33%)   2/3 (67%)    0/0 (0%)    |6/47 (13%)   10/47 (21%)  4/39 (10%)   6/32 (19%)   | 
|FIRST INCIDENCE    |     640          615          523          391         |620          729 (T)      685          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.086      P<0.001 **   P<0.001 **  |P=0.141      P=0.394      P=0.465      P=0.169      | 
|POLY 3             |     P=0.104      P=0.480      P=0.225      P=0.185     |P=0.328      P=0.373      P=0.558      P=0.330      | 
|POLY 1.5           |     P=0.339      P=0.568      P=0.367      P=0.467     |P=0.357      P=0.385      P=0.578      P=0.356      | 
|POLY 6             |     P=0.011 *    P=0.357      P=0.093      P=0.032 *   |P=0.284      P=0.359      P=0.533      P=0.288      | 
|LOGISTIC REGRESSION|     P=0.049 *    P=0.343      P=0.218      P=0.200     |P=0.297      P=0.376      P=0.570      P=0.338      | 
|COCH-ARM / FISHERS |     P=0.303N     P=0.500N     P=0.588N     P=0.322N    |P=0.389      P=0.399      P=0.605N     P=0.384      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/60 (27%)  10/60 (17%)  11/60 (18%)  4/60 (7%)   |13/60 (22%)  11/60 (18%)  17/60 (28%)  11/59 (19%)  | 
|POLY-3 RATE (b)    |     16/54.85     10/46.77     11/37.61     4/23.65     |13/57.31     11/55.97     17/54.55     11/53.70     | 
|POLY-3 PERCENT (g) |     29.2%        21.4%        29.3%        16.9%       |22.7%        19.7%        31.2%        20.5%        | 
|TERMINAL (d)       |     13/39 (33%)  1/18 (6%)    1/3 (33%)    0/0 (0%)    |10/47 (21%)  9/47 (19%)   11/39 (28%)  5/32 (16%)   | 
|FIRST INCIDENCE    |     537          378          519          391         |674          684          656          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.450      P<0.001 **   P=0.005 **  |P=0.202      P=0.423N     P=0.135      P=0.446      | 
|POLY 3             |     P=0.277N     P=0.251N     P=0.588      P=0.225N    |P=0.470      P=0.435N     P=0.212      P=0.480N     | 
|POLY 1.5           |     P=0.063N     P=0.191N     P=0.403N     P=0.046N*   |P=0.502      P=0.424N     P=0.233      P=0.454N     | 
|POLY 6             |     P=0.396      P=0.356N     P=0.331      P=0.539     |P=0.415      P=0.448N     P=0.188      P=0.525N     | 
|LOGISTIC REGRESSION|     P=0.301N     P=0.183N     P=0.385      P=0.490N    |P=0.455      P=0.435N     P=0.199      P=0.451N     | 
|COCH-ARM / FISHERS |     P=0.004N**   P=0.134N     P=0.191N     P=0.003N**  |P=0.530N     P=0.410N     P=0.264      P=0.428N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Diffuse                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    1/60 (2%)    3/60 (5%)   |3/60 (5%)    1/60 (2%)    0/60 (0%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      1/35.13      3/23.64     |3/56.86      1/55.92      0/53.74      1/52.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.9%         12.7%       |5.3%         1.8%         0.0%         1.9%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |3/47 (6%)    0/47 (0%)    0/39 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          628          439         |729 (T)      669          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   (e)          P=0.362      P=0.067     |P=0.196N     P=0.309N     P=0.156N     P=0.450N     | 
|POLY 3             |     P=0.016 *    (e)          P=0.418      P=0.038 *   |P=0.139N     P=0.312N     P=0.130N     P=0.336N     | 
|POLY 1.5           |     P=0.014 *    (e)          P=0.453      P=0.062     |P=0.136N     P=0.310N     P=0.126N     P=0.324N     | 
|POLY 6             |     P=0.033 *    (e)          P=0.371      P=0.022 *   |P=0.142N     P=0.314N     P=0.136N     P=0.357N     | 
|LOGISTIC REGRESSION|     P=0.094      (e)          P=0.536      P=0.646     |P=0.148N     P=0.308N     (e)          P=0.450N     | 
|COCH-ARM / FISHERS |     P=0.021 *    (e)          P=0.500      P=0.122     |P=0.133N     P=0.309N     P=0.122N     P=0.316N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/60 (10%)   2/60 (3%)    6/60 (10%)   3/60 (5%)   |9/60 (15%)   6/60 (10%)   14/60 (23%)  15/59 (25%)  | 
|POLY-3 RATE (b)    |     6/53.85      2/44.85      6/36.07      3/23.32     |9/57.10      6/56.48      14/54.43     15/54.35     | 
|POLY-3 PERCENT (g) |     11.1%        4.5%         16.6%        12.9%       |15.8%        10.6%        25.7%        27.6%        | 
|TERMINAL (d)       |     6/39 (15%)   0/18 (0%)    1/3 (33%)    0/0 (0%)    |7/47 (15%)   4/47 (9%)    11/39 (28%)  8/32 (25%)   | 
|FIRST INCIDENCE    |     729 (T)      589          502          404         |674          531          569          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.424N     P<0.001 **   P=0.012 *   |P=0.004 **   P=0.301N     P=0.085      P=0.032 *    | 
|POLY 3             |     P=0.348      P=0.202N     P=0.337      P=0.558     |P=0.021 *    P=0.298N     P=0.143      P=0.097      | 
|POLY 1.5           |     P=0.528      P=0.170N     P=0.458      P=0.493N    |P=0.024 *    P=0.295N     P=0.156      P=0.107      | 
|POLY 6             |     P=0.191      P=0.254N     P=0.194      P=0.302     |P=0.016 *    P=0.302N     P=0.126      P=0.082      | 
|LOGISTIC REGRESSION|     P=0.248      P=0.222N     P=0.122      P=0.595     |P=0.026 *    P=0.290N     P=0.135      P=0.118      | 
|COCH-ARM / FISHERS |     P=0.324N     P=0.136N     P=0.619N     P=0.245N    |P=0.028 *    P=0.291N     P=0.177      P=0.117      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    2/60 (3%)    2/60 (3%)    0/60 (0%)   |6/60 (10%)   7/60 (12%)   6/60 (10%)   7/59 (12%)   | 
|POLY-3 RATE (b)    |     3/54.09      2/44.41      2/35.74      0/21.46     |6/56.86      7/55.80      6/53.99      7/53.24      | 
|POLY-3 PERCENT (g) |     5.6%         4.5%         5.6%         0.0%        |10.6%        12.6%        11.1%        13.2%        | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |6/47 (13%)   6/47 (13%)   3/39 (8%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     674          658          519          ---         |729 (T)      702          707          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.368      P=0.594      P=0.342      P=1.000N    |P=0.215      P=0.498      P=0.492      P=0.266      | 
|POLY 3             |     P=0.374N     P=0.588N     P=0.670      P=0.352N    |P=0.409      P=0.486      P=0.583      P=0.450      | 
|POLY 1.5           |     P=0.204N     P=0.549N     P=0.603N     P=0.228N    |P=0.431      P=0.492      P=0.598      P=0.469      | 
|POLY 6             |     P=0.610      P=0.643N     P=0.557      P=0.520N    |P=0.372      P=0.479      P=0.564      P=0.416      | 
|LOGISTIC REGRESSION|     P=0.257N     P=0.609N     P=0.568N     P=0.804N    |P=0.398      P=0.470      P=0.541      P=0.478      | 
|COCH-ARM / FISHERS |     P=0.085N     P=0.500N     P=0.500N     P=0.122N    |P=0.453      P=0.500      P=0.619N     P=0.487      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/60 (12%)   4/60 (7%)    2/60 (3%)    0/59 (0%)   |8/60 (13%)   2/60 (3%)    3/60 (5%)    3/58 (5%)    | 
|POLY-3 RATE (b)    |     7/54.16      4/44.85      2/35.88      0/21.19     |8/57.12      2/55.80      3/53.91      3/52.12      | 
|POLY-3 PERCENT (g) |     12.9%        8.9%         5.6%         0.0%        |14.0%        3.6%         5.6%         5.8%         | 
|TERMINAL (d)       |     5/39 (13%)   3/18 (17%)   0/3 (0%)     0/0 (0%)    |5/47 (11%)   1/47 (2%)    1/39 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     674          428          519          ---         |691          702          706          708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.581N     P=0.565      P=0.533      P=1.000N    |P=0.178N     P=0.057N     P=0.171N     P=0.252N     | 
|POLY 3             |     P=0.054N     P=0.379N     P=0.226N     P=0.139N    |P=0.089N     P=0.051N     P=0.120N     P=0.133N     | 
|POLY 1.5           |     P=0.015N*    P=0.324N     P=0.150N     P=0.046N*   |P=0.085N     P=0.050N     P=0.112N     P=0.122N     | 
|POLY 6             |     P=0.214N     P=0.468N     P=0.367N     P=0.361N    |P=0.099N     P=0.053N     P=0.132N     P=0.153N     | 
|LOGISTIC REGRESSION|     P=0.032N*    P=0.378N     P=0.199N     P=0.714N    |P=0.106N     P=0.053N     P=0.125N     P=0.161N     | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.264N     P=0.081N     P=0.007N**  |P=0.081N     P=0.047N*    P=0.102N     P=0.113N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    25/60 (42%)  43/60 (72%)  45/60 (75%) |2/60 (3%)    7/60 (12%)   15/60 (25%)  24/60 (40%)  | 
|POLY-3 RATE (b)    |     2/53.85      25/53.76     43/51.12     45/49.76    |2/57.70      7/56.53      15/57.71     24/57.29     | 
|POLY-3 PERCENT (g) |     3.7%         46.5%        84.1%        90.4%       |3.5%         12.4%        26.0%        41.9%        | 
|TERMINAL (d)       |     2/39 (5%)    4/18 (22%)   3/3 (100%)   0/0 (0%)    |1/47 (2%)    5/47 (11%)   5/39 (13%)   9/33 (27%)   | 
|FIRST INCIDENCE    |     729 (T)      378          384          391         |401          505          370          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.086      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.076      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.078      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.075      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.090      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.081      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |2/60 (3%)    1/60 (2%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      0/21.46     |2/56.90      1/55.69      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |3.5%         1.8%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |719          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.509N     P=0.574N     P=0.326N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.145N     P=0.507N     P=0.520N     P=0.252N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.140N     P=0.504N     P=0.511N     P=0.245N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.152N     P=0.511N     P=0.531N     P=0.265N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.179N     P=0.513N     P=0.549N     P=0.282N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.135N     P=0.500N     P=0.500N     P=0.248N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |1/60 (2%)    0/60 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      0/21.46     |1/56.86      0/55.69      0/53.74      2/54.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |1.8%         0.0%         0.0%         3.7%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.258      P=0.500N     P=0.537N     P=0.456      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.280      P=0.504N     P=0.511N     P=0.484      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.283      P=0.502N     P=0.507N     P=0.492      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.275      P=0.506N     P=0.518N     P=0.469      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.303      (e)          (e)          P=0.523      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.287      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone: Cranium                                                                                                                    | 
|     Osteopetrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    0/60 (0%)    2/60 (3%)   |2/60 (3%)    6/60 (10%)   6/60 (10%)   10/60 (17%)  | 
|POLY-3 RATE (b)    |     0/53.85      1/44.05      0/34.77      2/22.37     |2/56.86      6/55.69      6/53.91      10/54.41     | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         8.9%        |3.5%         10.8%        11.1%        18.4%        | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    6/47 (13%)   4/39 (10%)   6/33 (18%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          581         |729 (T)      729 (T)      706          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.346      (e)          P=0.003 **  |P=0.002 **   P=0.135      P=0.089      P=0.004 **   | 
|POLY 3             |     P=0.122      P=0.460      (e)          P=0.111     |P=0.010 *    P=0.128      P=0.118      P=0.012 *    | 
|POLY 1.5           |     P=0.118      P=0.478      (e)          P=0.154     |P=0.011 *    P=0.132      P=0.125      P=0.013 *    | 
|POLY 6             |     P=0.166      P=0.435      (e)          P=0.078     |P=0.007 **   P=0.125      P=0.110      P=0.009 **   | 
|LOGISTIC REGRESSION|     P=0.031 *    P=0.346      (e)          P=0.139     |P=0.009 **   P=0.135      P=0.102      P=0.016 *    | 
|COCH-ARM / FISHERS |     P=0.146      P=0.500      (e)          P=0.248     |P=0.013 *    P=0.136      P=0.136      P=0.015 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone: Femur                                                                                                                      | 
|     Osteopetrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |8/60 (13%)   9/60 (15%)   13/60 (22%)  16/60 (27%)  | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      0/21.46     |8/58.22      9/55.69      13/54.05     16/55.76     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |13.7%        16.2%        24.1%        28.7%        | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |5/47 (11%)   9/47 (19%)   11/39 (28%)  9/33 (27%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |453          729 (T)      672          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.002 **   P=0.495      P=0.090      P=0.015 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.016 *    P=0.461      P=0.123      P=0.040 *    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.020 *    P=0.477      P=0.140      P=0.047 *    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.012 *    P=0.442      P=0.104      P=0.031 *    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.024 *    P=0.508      P=0.166      P=0.083      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.024 *    P=0.500      P=0.168      P=0.054      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/60 (10%)   3/60 (5%)    2/60 (3%)    1/60 (2%)   |6/60 (10%)   10/60 (17%)  5/60 (8%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     6/55.95      3/44.99      2/35.61      1/21.88     |6/56.98      10/56.79     5/54.34      3/53.36      | 
|POLY-3 PERCENT (g) |     10.7%        6.7%         5.6%         4.6%        |10.5%        17.6%        9.2%         5.6%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    1/3 (33%)    0/0 (0%)    |5/47 (11%)   5/47 (11%)   2/39 (5%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     441          639          391          608         |700          531          636          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.573      P=0.477N     P=0.591N     P=0.686     |P=0.246N     P=0.210      P=0.602N     P=0.435N     | 
|POLY 3             |     P=0.181N     P=0.361N     P=0.329N     P=0.367N    |P=0.130N     P=0.208      P=0.533N     P=0.277N     | 
|POLY 1.5           |     P=0.081N     P=0.308N     P=0.232N     P=0.186N    |P=0.116N     P=0.209      P=0.519N     P=0.261N     | 
|POLY 6             |     P=0.391N     P=0.440N     P=0.488N     P=0.613N    |P=0.157N     P=0.207      P=0.550N     P=0.306N     | 
|LOGISTIC REGRESSION|     P=0.006N**   P=0.094N     P=0.024N*    P=0.010N*   |P=0.109N     P=0.212      P=0.522N     P=0.369N     | 
|COCH-ARM / FISHERS |     P=0.026N*    P=0.245N     P=0.136N     P=0.057N    |P=0.102N     P=0.211      P=0.500N     P=0.245N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    1/60 (2%)    1/60 (2%)    2/60 (3%)   |2/60 (3%)    4/60 (7%)    0/60 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     3/54.87      1/44.05      1/35.61      2/23.01     |2/56.86      4/56.85      0/53.74      3/53.48      | 
|POLY-3 PERCENT (g) |     5.5%         2.3%         2.8%         8.7%        |3.5%         7.0%         0.0%         5.6%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    1/47 (2%)    0/39 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     533          729 (T)      391          421         |729 (T)      531          ---          691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.282      P=0.484N     P=0.579N     P=0.367     |P=0.483      P=0.332      P=0.280N     P=0.354      | 
|POLY 3             |     P=0.589N     P=0.388N     P=0.470N     P=0.492     |P=0.556N     P=0.338      P=0.250N     P=0.472      | 
|POLY 1.5           |     P=0.503N     P=0.350N     P=0.396N     P=0.654     |P=0.544N     P=0.338      P=0.245N     P=0.486      | 
|POLY 6             |     P=0.580      P=0.445N     P=0.578N     P=0.309     |P=0.553      P=0.338      P=0.258N     P=0.449      | 
|LOGISTIC REGRESSION|     P=0.091N     P=0.240N     P=0.076N     P=0.099N    |P=0.504N     P=0.356      (e)          P=0.427      | 
|COCH-ARM / FISHERS |     P=0.392N     P=0.309N     P=0.309N     P=0.500N    |P=0.529N     P=0.340      P=0.248N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/59 (2%)    3/57 (5%)    6/54 (11%)   25/53 (47%)  | 
|POLY-3 RATE (b)    |                                                        |1/55.90      3/53.54      6/49.21      25/48.82     | 
|POLY-3 PERCENT (g) |                                                        |1.8%         5.6%         12.2%        51.2%        | 
|TERMINAL (d)       |                                                        |0/46 (0%)    1/45 (2%)    2/36 (6%)    17/32 (53%)  | 
|FIRST INCIDENCE    |                                                        |719          582          569          603          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   P=0.293      P=0.041 *    P<0.001 **   | 
|POLY 3             |                                                        |P<0.001 **   P=0.291      P=0.039 *    P<0.001 **   | 
|POLY 1.5           |                                                        |P<0.001 **   P=0.292      P=0.041 *    P<0.001 **   | 
|POLY 6             |                                                        |P<0.001 **   P=0.290      P=0.037 *    P<0.001 **   | 
|LOGISTIC REGRESSION|                                                        |P<0.001 **   P=0.305      P=0.053      P<0.001 **   | 
|COCH-ARM / FISHERS |                                                        |P<0.001 **   P=0.296      P=0.044 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/59 (3%)    4/57 (7%)    4/54 (7%)    2/53 (4%)    | 
|POLY-3 RATE (b)    |                                                        |2/56.01      4/52.95      4/48.18      2/48.25      | 
|POLY-3 PERCENT (g) |                                                        |3.6%         7.6%         8.3%         4.2%         | 
|TERMINAL (d)       |                                                        |1/46 (2%)    3/45 (7%)    4/36 (11%)   1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |691          708          729 (T)      464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.404      P=0.326      P=0.242      P=0.609      | 
|POLY 3             |                                                        |P=0.489      P=0.313      P=0.271      P=0.639      | 
|POLY 1.5           |                                                        |P=0.506      P=0.317      P=0.282      P=0.647      | 
|POLY 6             |                                                        |P=0.460      P=0.308      P=0.258      P=0.624      | 
|LOGISTIC REGRESSION|                                                        |P=0.522      P=0.313      P=0.254      P=0.686      | 
|COCH-ARM / FISHERS |                                                        |P=0.520      P=0.323      P=0.298      P=0.649      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/59 (8%)    1/57 (2%)    4/54 (7%)    1/53 (2%)    | 
|POLY-3 RATE (b)    |                                                        |5/56.01      1/52.86      4/48.26      1/47.50      | 
|POLY-3 PERCENT (g) |                                                        |8.9%         1.9%         8.3%         2.1%         | 
|TERMINAL (d)       |                                                        |4/46 (9%)    1/45 (2%)    3/36 (8%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |691          729 (T)      708          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.255N     P=0.112N     P=0.635N     P=0.199N     | 
|POLY 3             |                                                        |P=0.183N     P=0.117N     P=0.592N     P=0.145N     | 
|POLY 1.5           |                                                        |P=0.175N     P=0.115N     P=0.577N     P=0.137N     | 
|POLY 6             |                                                        |P=0.197N     P=0.119N     P=0.610N     P=0.159N     | 
|LOGISTIC REGRESSION|                                                        |P=0.215N     P=0.118N     P=0.615N     P=0.163N     | 
|COCH-ARM / FISHERS |                                                        |P=0.167N     P=0.111N     P=0.556N     P=0.130N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/59 (7%)    4/57 (7%)    6/54 (11%)   5/53 (9%)    | 
|POLY-3 RATE (b)    |                                                        |4/56.13      4/52.86      6/49.51      5/47.98      | 
|POLY-3 PERCENT (g) |                                                        |7.1%         7.6%         12.1%        10.4%        | 
|TERMINAL (d)       |                                                        |2/46 (4%)    4/45 (9%)    2/36 (6%)    4/32 (13%)   | 
|FIRST INCIDENCE    |                                                        |691          729 (T)      523          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.186      P=0.624      P=0.287      P=0.324      | 
|POLY 3             |                                                        |P=0.251      P=0.609      P=0.295      P=0.403      | 
|POLY 1.5           |                                                        |P=0.265      P=0.615      P=0.304      P=0.418      | 
|POLY 6             |                                                        |P=0.227      P=0.602      P=0.283      P=0.379      | 
|LOGISTIC REGRESSION|                                                        |P=0.291      P=0.612      P=0.359      P=0.432      | 
|COCH-ARM / FISHERS |                                                        |P=0.279      P=0.622      P=0.316      P=0.432      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Atypia Cellular                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/60 (65%)  32/60 (53%)  27/59 (46%)  21/60 (35%) |                                                    | 
|POLY-3 RATE (b)    |     39/57.69     32/51.29     27/44.28     21/34.23    |                                                    | 
|POLY-3 PERCENT (g) |     67.6%        62.4%        61.0%        61.4%       |                                                    | 
|TERMINAL (d)       |     25/39 (64%)  14/18 (78%)  2/3 (67%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     533          378          384          404         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.031 *    P<0.001 **   P<0.001 **  |                                                    | 
|POLY 3             |     P=0.244N     P=0.350N     P=0.306N     P=0.347N    |                                                    | 
|POLY 1.5           |     P=0.029N*    P=0.230N     P=0.128N     P=0.044N*   |                                                    | 
|POLY 6             |     P=0.255      P=0.578N     P=0.534      P=0.242     |                                                    | 
|LOGISTIC REGRESSION|     P=0.137N     P=0.232N     P=0.195N     P=0.350N    |                                                    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.133N     P=0.027N*    P<0.001N**  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/59 (0%)    0/60 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/53.85      2/44.40      0/34.22      0/21.46     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          632          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443      P=0.127      (e)          (e)         |                                                    | 
|POLY 3             |     P=0.620      P=0.198      (e)          (e)         |                                                    | 
|POLY 1.5           |     P=0.565N     P=0.215      (e)          (e)         |                                                    | 
|POLY 6             |     P=0.429      P=0.175      (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.702      P=0.211      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.383N     P=0.248      (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     1/1 (100%)   1/2 (50%)    1/1 (100%)  |1/3 (33%)    2/3 (67%)    1/2 (50%)    1/1 (100%)   | 
|POLY-3 RATE (b)    |     0/2.00       1/1.00       1/1.15       1/1.00      |1/3.00       2/2.90       1/1.92       1/1.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       86.6%        100.0%      |33.3%        68.9%        52.1%        100.0%       | 
|TERMINAL (d)       |     0/2 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |1/3 (33%)    2/2 (100%)   0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          621          581          512         |729 (T)      729 (T)      672          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.357      P=0.376      P=0.186     |P=0.081      P=0.309      P=0.484      P=0.473      | 
|POLY 3             |     P=0.013 *    P=1.000N     P=0.362      P=1.000N    |P=0.300      P=0.486      P=0.661      P=0.500      | 
|POLY 1.5           |     P=0.045 *    P=1.000N     P=0.415      P=1.000N    |P=0.305      P=0.493      P=0.666      P=0.500      | 
|POLY 6             |     P=0.004 **   P=1.000N     P=0.325      P=1.000N    |P=0.290      P=0.472      P=0.653      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.119      (e)          P=0.651      (e)         |P=0.698      P=0.309      P=0.775N     (e)          | 
|COCH-ARM / FISHERS |     P=0.145      P=0.333      P=0.500      P=0.333     |P=0.273      P=0.500      P=0.700      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/2 (50%)    1/1 (100%)   1/2 (50%)    1/1 (100%)  |2/3 (67%)    2/3 (67%)    1/2 (50%)    1/1 (100%)   | 
|POLY-3 RATE (b)    |     1/2.00       1/1.00       1/1.15       1/1.00      |2/3.00       2/2.90       1/1.92       1/1.00       | 
|POLY-3 PERCENT (g) |     50.0%        100.0%       86.6%        100.0%      |66.7%        68.9%        52.1%        100.0%       | 
|TERMINAL (d)       |     1/2 (50%)    0/0 (0%)     0/0 (0%)     0/0 (0%)    |2/3 (67%)    2/2 (100%)   0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      621          581          512         |729 (T)      729 (T)      672          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.357      P=0.376      P=0.186     |P=0.117      P=0.581      P=0.484      P=0.473      | 
|POLY 3             |     P=0.406      P=0.614      P=0.658      P=0.614     |P=0.537      P=0.753      P=0.689N     P=0.691      | 
|POLY 1.5           |     P=0.421      P=0.614      P=0.703      P=0.614     |P=0.540      P=0.757      P=0.679N     P=0.691      | 
|POLY 6             |     P=0.401      P=0.614      P=0.625      P=0.614     |P=0.532      P=0.745      P=0.707N     P=0.691      | 
|LOGISTIC REGRESSION|     P=0.214      (e)          P=0.800      (e)         |P=0.606N     P=0.581      P=0.631N     (e)          | 
|COCH-ARM / FISHERS |     P=0.460      P=0.667      P=0.833N     P=0.667     |P=0.554      P=0.800N     P=0.700N     P=0.750      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     40/60 (67%)  43/60 (72%)  43/60 (72%)  37/60 (62%) |22/60 (37%)  16/60 (27%)  13/60 (22%)  13/60 (22%)  | 
|POLY-3 RATE (b)    |     40/57.01     43/54.24     43/51.92     37/45.30    |22/57.45     16/55.69     13/53.91     13/54.37     | 
|POLY-3 PERCENT (g) |     70.2%        79.3%        82.8%        81.7%       |38.3%        28.7%        24.1%        23.9%        | 
|TERMINAL (d)       |     27/39 (69%)  15/18 (83%)  3/3 (100%)   0/0 (0%)    |19/47 (40%)  16/47 (34%)  11/39 (28%)  8/33 (24%)   | 
|FIRST INCIDENCE    |     533          428          298          391         |620          729 (T)      706          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.244N     P=0.164N     P=0.162N     P=0.300N     | 
|POLY 3             |     P=0.050      P=0.176      P=0.078      P=0.113     |P=0.045N*    P=0.189N     P=0.078N     P=0.073N     | 
|POLY 1.5           |     P=0.270      P=0.246      P=0.158      P=0.376     |P=0.038N*    P=0.177N     P=0.066N     P=0.062N     | 
|POLY 6             |     P<0.001 **   P=0.097      P=0.025 *    P=0.011 *   |P=0.059N     P=0.206N     P=0.097N     P=0.096N     | 
|LOGISTIC REGRESSION|     P=0.234      P=0.159      P=0.114      P=0.468     |P=0.082N     P=0.192N     P=0.100N     P=0.088N     | 
|COCH-ARM / FISHERS |     P=0.294N     P=0.346      P=0.346      P=0.352N    |P=0.032N*    P=0.163N     P=0.054N     P=0.054N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    2/60 (3%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/54.06      0/44.05      0/34.77      2/22.58     |0/56.86      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         0.0%         0.0%         8.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     674          ---          ---          519         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.074      P=0.392N     P=0.649N     P=0.036 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.607      P=0.286N     P=0.347N     P=0.380     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.564      P=0.264N     P=0.296N     P=0.521     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.607N     P=0.321N     P=0.425N     P=0.240     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.484      P=0.291N     P=0.420N     P=0.612     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.567      P=0.248N     P=0.248N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    0/60 (0%)    0/60 (0%)    2/60 (3%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/53.85      0/44.05      0/34.77      2/22.65     |0/56.86      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         0.0%         0.0%         8.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          483         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030 *    P=0.654N     P=0.952N     P=0.055     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.344      P=0.540N     P=0.583N     P=0.252     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.291      P=0.522N     P=0.548N     P=0.351     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.493      P=0.565N     P=0.632N     P=0.163     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.281      (e)          (e)          P=0.531     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.287      P=0.500N     P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    3/60 (5%)    2/60 (3%)   |0/60 (0%)    1/59 (2%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      1/44.05      3/35.98      2/22.60     |0/56.86      1/54.87      1/53.83      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         8.3%         8.9%        |0.0%         1.8%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      502          534         |---          729 (T)      707          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.346      P=0.029 *    P=0.048 *   |P=0.603      P=0.500      P=0.476      (e)          | 
|POLY 3             |     P=0.022 *    P=0.460      P=0.065      P=0.111     |P=0.635N     P=0.493      P=0.489      (e)          | 
|POLY 1.5           |     P=0.044 *    P=0.478      P=0.085      P=0.155     |P=0.626N     P=0.494      P=0.494      (e)          | 
|POLY 6             |     P=0.012 *    P=0.435      P=0.045 *    P=0.079     |P=0.611      P=0.491      P=0.483      (e)          | 
|LOGISTIC REGRESSION|     P=0.068      P=0.346      P=0.160      P=0.361     |P=0.638N     P=0.500      P=0.498      (e)          | 
|COCH-ARM / FISHERS |     P=0.111      P=0.500      P=0.122      P=0.248     |P=0.616N     P=0.496      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)   |2/60 (3%)    0/59 (0%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      1/22.20     |2/56.86      0/54.87      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |3.5%         0.0%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          464         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157      (e)          (e)          P=0.446     |P=0.215N     P=0.239N     P=0.565N     P=0.319N     | 
|POLY 3             |     P=0.270      (e)          (e)          P=0.349     |P=0.163N     P=0.246N     P=0.520N     P=0.252N     | 
|POLY 1.5           |     P=0.203      (e)          (e)          P=0.413     |P=0.160N     P=0.244N     P=0.511N     P=0.245N     | 
|POLY 6             |     P=0.454      (e)          (e)          P=0.286     |P=0.168N     P=0.247N     P=0.531N     P=0.265N     | 
|LOGISTIC REGRESSION|     P=0.366      (e)          (e)          P=0.944     |P=0.215N     (e)          P=0.565N     (e)          | 
|COCH-ARM / FISHERS |     P=0.188      (e)          (e)          P=0.500     |P=0.157N     P=0.252N     P=0.500N     P=0.248N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)   |2/60 (3%)    1/59 (2%)    1/60 (2%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/53.85      1/44.05      0/34.77      0/21.46     |2/56.86      1/54.87      1/53.74      1/53.86      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |3.5%         1.8%         1.9%         1.9%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    1/47 (2%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500      P=0.346      (e)          (e)         |P=0.453N     P=0.500N     P=0.565N     P=0.581N     | 
|POLY 3             |     P=0.710      P=0.460      (e)          (e)         |P=0.372N     P=0.512N     P=0.520N     P=0.519N     | 
|POLY 1.5           |     P=0.651N     P=0.478      (e)          (e)         |P=0.366N     P=0.510N     P=0.511N     P=0.509N     | 
|POLY 6             |     P=0.619      P=0.435      (e)          (e)         |P=0.384N     P=0.515N     P=0.531N     P=0.535N     | 
|LOGISTIC REGRESSION|     (e)          P=0.346      (e)          (e)         |P=0.350N     P=0.500N     P=0.565N     P=0.476N     | 
|COCH-ARM / FISHERS |     P=0.517N     P=0.500      (e)          (e)         |P=0.357N     P=0.506N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     56/60 (93%)  59/60 (98%)  56/60 (93%)  56/60 (93%) |53/60 (88%)  45/59 (76%)  48/60 (80%)  52/60 (87%)  | 
|POLY-3 RATE (b)    |     56/59.40     59/59.65     56/58.13     56/57.43    |53/59.05     45/58.03     48/58.04     52/57.51     | 
|POLY-3 PERCENT (g) |     94.3%        98.9%        96.3%        97.5%       |89.8%        77.6%        82.7%        90.4%        | 
|TERMINAL (d)       |     37/39 (95%)  18/18 (100%) 3/3 (100%)   0/0 (0%)    |43/47 (92%)  36/47 (77%)  34/39 (87%)  32/33 (97%)  | 
|FIRST INCIDENCE    |     441          378          298          359         |401          429          370          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.003 **   P=0.119N     P=0.327      P=0.008 **   | 
|POLY 3             |     P=0.281      P=0.167      P=0.460      P=0.320     |P=0.379      P=0.058N     P=0.191N     P=0.580      | 
|POLY 1.5           |     P=0.448      P=0.172      P=0.522      P=0.443     |P=0.452      P=0.060N     P=0.170N     P=0.591N     | 
|POLY 6             |     P=0.146      P=0.166      P=0.390      P=0.233     |P=0.271      P=0.058N     P=0.239N     P=0.452      | 
|LOGISTIC REGRESSION|     P=0.502      P=0.178      P=0.530      P=0.612     |P=0.459      P=0.073N     P=0.199N     P=0.613      | 
|COCH-ARM / FISHERS |     P=0.400N     P=0.182      P=0.641N     P=0.641N    |P=0.532      P=0.068N     P=0.159N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    3/60 (5%)    0/60 (0%)    1/60 (2%)   |9/60 (15%)   10/59 (17%)  4/60 (7%)    11/60 (18%)  | 
|POLY-3 RATE (b)    |     3/54.07      3/46.16      0/34.77      1/21.81     |9/57.02      10/55.10     4/54.17      11/53.64     | 
|POLY-3 PERCENT (g) |     5.6%         6.5%         0.0%         4.6%        |15.8%        18.2%        7.4%         20.5%        | 
|TERMINAL (d)       |     2/39 (5%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |7/47 (15%)   8/47 (17%)   2/39 (5%)    9/33 (27%)   | 
|FIRST INCIDENCE    |     673          378          ---          632         |691          695          636          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.595N     P=0.484      P=0.578N     P=0.046 *   |P=0.222      P=0.492      P=0.200N     P=0.144      | 
|POLY 3             |     P=0.295N     P=0.587      P=0.219N     P=0.629N    |P=0.456      P=0.467      P=0.139N     P=0.346      | 
|POLY 1.5           |     P=0.182N     P=0.622      P=0.170N     P=0.485N    |P=0.482      P=0.474      P=0.131N     P=0.374      | 
|POLY 6             |     P=0.487N     P=0.531      P=0.305N     P=0.544     |P=0.414      P=0.461      P=0.151N     P=0.300      | 
|LOGISTIC REGRESSION|     P=0.024N*    P=0.382N     P=0.333N     P=0.647     |P=0.390      P=0.459      P=0.141N     P=0.234      | 
|COCH-ARM / FISHERS |     P=0.095N     P=0.660N     P=0.122N     P=0.309N    |P=0.511      P=0.484      P=0.120N     P=0.404      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    3/60 (5%)    0/60 (0%)    2/60 (3%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/54.15      3/45.27      0/34.77      2/22.62     |0/56.86      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         6.6%         0.0%         8.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     649          465          ---          419         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.103      P=0.186      P=0.677N     P=0.060     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.341      P=0.245      P=0.584N     P=0.250     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.428      P=0.271      P=0.548N     P=0.351     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.259      P=0.210      P=0.633N     P=0.162     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.426N     P=0.465      P=0.512N     P=0.766     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.569      P=0.309      P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    1/60 (2%)    0/60 (0%)   |2/60 (3%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      1/44.07      1/34.97      0/21.46     |2/57.62      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.9%         0.0%        |3.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          726          676          ---         |453          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.080      P=0.372      P=0.273      (e)         |P=0.079N     P=0.240N     P=0.262N     P=0.276N     | 
|POLY 3             |     P=0.383      P=0.460      P=0.417      (e)         |P=0.066N     P=0.249N     P=0.254N     P=0.255N     | 
|POLY 1.5           |     P=0.502      P=0.478      P=0.453      (e)         |P=0.066N     P=0.246N     P=0.247N     P=0.247N     | 
|POLY 6             |     P=0.245      P=0.435      P=0.370      (e)         |P=0.065N     P=0.251N     P=0.262N     P=0.269N     | 
|LOGISTIC REGRESSION|     P=0.221      P=0.376      P=0.412      (e)         |P=0.052N     P=0.222N     P=0.173N     P=0.229N     | 
|COCH-ARM / FISHERS |     P=0.618N     P=0.500      P=0.500      (e)         |P=0.067N     P=0.252N     P=0.248N     P=0.248N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    12/60 (20%)  14/60 (23%)  9/60 (15%)  |9/60 (15%)   10/59 (17%)  7/60 (12%)   17/60 (28%)  | 
|POLY-3 RATE (b)    |     5/54.15      12/47.60     14/38.40     9/26.90     |9/57.47      10/55.18     7/54.34      17/53.97     | 
|POLY-3 PERCENT (g) |     9.2%         25.2%        36.5%        33.5%       |15.7%        18.1%        12.9%        31.5%        | 
|TERMINAL (d)       |     3/39 (8%)    3/18 (17%)   2/3 (67%)    0/0 (0%)    |6/47 (13%)   7/47 (15%)   4/39 (10%)   14/33 (42%)  | 
|FIRST INCIDENCE    |     673          428          527          463         |620          695          636          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P=0.008 **   P=0.488      P=0.527N     P=0.008 **   | 
|POLY 3             |     P<0.001 **   P=0.027 *    P<0.001 **   P=0.013 *   |P=0.039 *    P=0.462      P=0.441N     P=0.038 *    | 
|POLY 1.5           |     P=0.014 *    P=0.038 *    P=0.005 **   P=0.050     |P=0.047 *    P=0.471      P=0.422N     P=0.047 *    | 
|POLY 6             |     P<0.001 **   P=0.016 *    P<0.001 **   P=0.002 **  |P=0.029 *    P=0.452      P=0.467N     P=0.026 *    | 
|LOGISTIC REGRESSION|     P=0.014 *    P=0.077      P<0.001 **   P=0.136     |P=0.037 *    P=0.473      P=0.408N     P=0.034 *    | 
|COCH-ARM / FISHERS |     P=0.183      P=0.057      P=0.022 *    P=0.197     |P=0.059      P=0.484      P=0.395N     P=0.060      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    2/60 (3%)    2/60 (3%)   |2/60 (3%)    3/59 (5%)    4/60 (7%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     0/53.85      1/44.14      2/35.32      2/22.83     |2/56.86      3/54.92      4/53.74      4/53.75      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         5.7%         8.8%        |3.5%         5.5%         7.4%         7.4%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    2/47 (4%)    4/39 (10%)   1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          707          636          483         |729 (T)      716          729 (T)      663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.387      P=0.071      P=0.142     |P=0.114      P=0.495      P=0.255      P=0.225      | 
|POLY 3             |     P=0.039 *    P=0.461      P=0.159      P=0.112     |P=0.207      P=0.484      P=0.312      P=0.312      | 
|POLY 1.5           |     P=0.061      P=0.478      P=0.190      P=0.156     |P=0.221      P=0.488      P=0.323      P=0.325      | 
|POLY 6             |     P=0.030 *    P=0.435      P=0.125      P=0.079     |P=0.186      P=0.481      P=0.298      P=0.292      | 
|LOGISTIC REGRESSION|     P=0.089      P=0.431      P=0.176      P=0.658     |P=0.182      P=0.479      P=0.255      P=0.318      | 
|COCH-ARM / FISHERS |     P=0.123      P=0.500      P=0.248      P=0.248     |P=0.234      P=0.492      P=0.340      P=0.340      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    1/60 (2%)    1/60 (2%)    4/60 (7%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/53.94      1/44.45      1/34.92      4/24.16     |0/56.86      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         2.3%         2.9%         16.6%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     707          616          691          419         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.668      P=0.370      P=0.012 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.045 *    P=0.716      P=0.654      P=0.043 *   |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.051      P=0.736      P=0.704      P=0.083     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.054      P=0.684      P=0.579      P=0.019 *   |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.151      P=0.755N     P=0.596      P=0.543     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.080      P=0.752N     P=0.752N     P=0.182     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/60 (63%)  22/60 (37%)  21/60 (35%)  25/60 (42%) |51/60 (85%)  56/59 (95%)  60/60 (100%) 54/60 (90%)  | 
|POLY-3 RATE (b)    |     38/54.87     22/47.62     21/41.49     25/37.78    |51/58.27     56/57.66     60/60.00     54/58.46     | 
|POLY-3 PERCENT (g) |     69.3%        46.2%        50.6%        66.2%       |87.5%        97.1%        100.0%       92.4%        | 
|TERMINAL (d)       |     34/39 (87%)  12/18 (67%)  3/3 (100%)   0/0 (0%)    |44/47 (94%)  47/47 (100%) 39/39 (100%) 31/33 (94%)  | 
|FIRST INCIDENCE    |     441          428          483          391         |401          495          370          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.300      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.162      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.269N     P=0.010N*    P=0.037N*    P=0.463N    |P=0.130      P=0.042 *    P=0.004 **   P=0.275      | 
|POLY 1.5           |     P=0.088N     P=0.005N**   P=0.010N*    P=0.135N    |P=0.134      P=0.048 *    P=0.003 **   P=0.282      | 
|POLY 6             |     P=0.409      P=0.025N*    P=0.167N     P=0.238     |P=0.124      P=0.042 *    P=0.007 **   P=0.266      | 
|LOGISTIC REGRESSION|     P=0.296      P=0.089N     P=0.386N     P=0.516     |P=0.095      P=0.038 *    P<0.001 **   P=0.196      | 
|COCH-ARM / FISHERS |     P=0.015N*    P=0.003N**   P=0.002N**   P=0.014N*   |P=0.144      P=0.067      P<0.001 **   P=0.291      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/60 (48%)  29/60 (48%)  34/60 (57%)  31/60 (52%) |16/60 (27%)  30/59 (51%)  28/60 (47%)  33/60 (55%)  | 
|POLY-3 RATE (b)    |     29/54.06     29/49.14     34/48.88     31/41.29    |16/57.01     30/55.01     28/55.80     33/54.91     | 
|POLY-3 PERCENT (g) |     53.6%        59.0%        69.6%        75.1%       |28.1%        54.5%        50.2%        60.1%        | 
|TERMINAL (d)       |     26/39 (67%)  13/18 (72%)  2/3 (67%)    0/0 (0%)    |15/47 (32%)  28/47 (60%)  22/39 (56%)  22/33 (67%)  | 
|FIRST INCIDENCE    |     705          559          298          391         |691          708          432          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.006 **   P=0.003 **   P<0.001 **   | 
|POLY 3             |     P=0.006 **   P=0.357      P=0.060      P=0.018 *   |P<0.001 **   P=0.003 **   P=0.011 *    P<0.001 **   | 
|POLY 1.5           |     P=0.047 *    P=0.449      P=0.114      P=0.105     |P<0.001 **   P=0.004 **   P=0.014 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.248      P=0.020 *    P<0.001 **  |P<0.001 **   P=0.002 **   P=0.009 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.009 **   P=0.079      P=0.056      P=0.022 *   |P<0.001 **   P=0.003 **   P=0.012 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.295      P=0.572N     P=0.232      P=0.428     |P=0.003 **   P=0.006 **   P=0.018 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    3/60 (5%)    1/60 (2%)    2/60 (3%)   |0/60 (0%)    0/59 (0%)    1/60 (2%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     3/53.85      3/44.14      1/34.77      2/22.48     |0/56.86      0/54.87      1/53.74      2/53.58      | 
|POLY-3 PERCENT (g) |     5.6%         6.8%         2.9%         8.9%        |0.0%         0.0%         1.9%         3.7%         | 
|TERMINAL (d)       |     3/39 (8%)    2/18 (11%)   1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      707          729 (T)      502         |---          ---          729 (T)      687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.308      P=0.333      P=0.027 *   |P=0.041 *    (e)          P=0.463      P=0.193      | 
|POLY 3             |     P=0.572      P=0.567      P=0.472N     P=0.491     |P=0.057      (e)          P=0.489      P=0.225      | 
|POLY 1.5           |     P=0.458N     P=0.610      P=0.397N     P=0.653     |P=0.060      (e)          P=0.493      P=0.231      | 
|POLY 6             |     P=0.438      P=0.503      P=0.581N     P=0.306     |P=0.053      (e)          P=0.482      P=0.214      | 
|LOGISTIC REGRESSION|     P=0.117      P=0.369      P=0.333      P=0.393     |P=0.059      (e)          P=0.463      P=0.242      | 
|COCH-ARM / FISHERS |     P=0.288N     P=0.660N     P=0.309N     P=0.500N    |P=0.062      (e)          P=0.500      P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/60 (12%)   18/60 (30%)  29/60 (48%)  24/60 (40%) |5/60 (8%)    12/59 (20%)  25/60 (42%)  32/60 (53%)  | 
|POLY-3 RATE (b)    |     7/53.98      18/46.38     29/44.55     24/35.61    |5/56.86      12/55.96     25/55.67     32/55.68     | 
|POLY-3 PERCENT (g) |     13.0%        38.8%        65.1%        67.4%       |8.8%         21.4%        44.9%        57.5%        | 
|TERMINAL (d)       |     5/39 (13%)   10/18 (56%)  2/3 (67%)    0/0 (0%)    |5/47 (11%)   7/47 (15%)   15/39 (39%)  18/33 (55%)  | 
|FIRST INCIDENCE    |     705          555          432          404         |729 (T)      505          569          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.062      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.052      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.052      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.052      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.053      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.053      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    6/60 (10%)   2/60 (3%)    2/60 (3%)   |0/60 (0%)    2/59 (3%)    1/60 (2%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     0/53.85      6/46.68      2/35.10      2/22.80     |0/56.86      2/55.54      1/54.22      3/53.81      | 
|POLY-3 PERCENT (g) |     0.0%         12.9%        5.7%         8.8%        |0.0%         3.6%         1.8%         5.6%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    1/3 (33%)    0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     ---          471          637          419         |---          505          586          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.019 *    P=0.008 **   P=0.016 *    P=0.088     |P=0.071      P=0.240      P=0.489      P=0.084      | 
|POLY 3             |     P=0.077      P=0.010 *    P=0.158      P=0.112     |P=0.089      P=0.232      P=0.491      P=0.110      | 
|POLY 1.5           |     P=0.202      P=0.012 *    P=0.189      P=0.156     |P=0.094      P=0.233      P=0.494      P=0.115      | 
|POLY 6             |     P=0.014 *    P=0.007 **   P=0.124      P=0.079     |P=0.081      P=0.232      P=0.485      P=0.102      | 
|LOGISTIC REGRESSION|     P=0.512N     P=0.057      P=0.102      P=0.668     |P=0.111      P=0.241      P=0.556      P=0.131      | 
|COCH-ARM / FISHERS |     P=0.467      P=0.014 *    P=0.248      P=0.248     |P=0.100      P=0.244      P=0.500      P=0.122      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    2/60 (3%)    2/60 (3%)   |0/60 (0%)    1/59 (2%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/53.85      0/44.05      2/35.71      2/22.80     |0/56.86      1/54.87      1/53.82      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         0.0%         5.6%         8.8%        |0.0%         1.8%         1.9%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          581          471         |---          729 (T)      709          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.025 *    P=0.420N     P=0.238      P=0.121     |P=0.591      P=0.500      P=0.461      (e)          | 
|POLY 3             |     P=0.291      P=0.285N     P=0.538      P=0.384     |P=0.635N     P=0.493      P=0.489      (e)          | 
|POLY 1.5           |     P=0.331      P=0.263N     P=0.608      P=0.523     |P=0.626N     P=0.494      P=0.494      (e)          | 
|POLY 6             |     P=0.293      P=0.319N     P=0.438      P=0.243     |P=0.612      P=0.491      P=0.483      (e)          | 
|LOGISTIC REGRESSION|     P=0.443      (e)          P=0.658      P=0.724     |P=0.641N     P=0.500      P=0.496      (e)          | 
|COCH-ARM / FISHERS |     P=0.431      P=0.248N     P=0.691N     P=0.691N    |P=0.616N     P=0.496      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    8/60 (13%)   8/60 (13%)   5/60 (8%)   |9/60 (15%)   13/59 (22%)  10/60 (17%)  7/60 (12%)   | 
|POLY-3 RATE (b)    |     5/54.30      8/45.26      8/38.20      5/24.50     |9/57.19      13/54.92     10/54.16     7/53.60      | 
|POLY-3 PERCENT (g) |     9.2%         17.7%        20.9%        20.4%       |15.7%        23.7%        18.5%        13.1%        | 
|TERMINAL (d)       |     3/39 (8%)    4/18 (22%)   0/3 (0%)     0/0 (0%)    |7/47 (15%)   12/47 (26%)  6/39 (15%)   5/33 (15%)   | 
|FIRST INCIDENCE    |     649          567          483          463         |674          716          685          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.041 *    P=0.005 **   P<0.001 **  |P=0.489      P=0.236      P=0.349      P=0.551      | 
|POLY 3             |     P=0.062      P=0.172      P=0.102      P=0.186     |P=0.315N     P=0.206      P=0.449      P=0.448N     | 
|POLY 1.5           |     P=0.209      P=0.216      P=0.163      P=0.360     |P=0.284N     P=0.215      P=0.470      P=0.422N     | 
|POLY 6             |     P=0.008 **   P=0.119      P=0.047 *    P=0.068     |P=0.371N     P=0.197      P=0.421      P=0.494N     | 
|LOGISTIC REGRESSION|     P=0.233      P=0.163      P=0.286      P=0.492     |P=0.389N     P=0.203      P=0.433      P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.521N     P=0.279      P=0.279      P=0.628N    |P=0.252N     P=0.226      P=0.500      P=0.395N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    5/60 (8%)    11/60 (18%)  20/60 (33%) |15/60 (25%)  11/59 (19%)  6/60 (10%)   12/60 (20%)  | 
|POLY-3 RATE (b)    |     1/53.85      5/44.90      11/39.75     20/33.67    |15/56.86     11/55.25     6/54.69      12/53.99     | 
|POLY-3 PERCENT (g) |     1.9%         11.1%        27.7%        59.4%       |26.4%        19.9%        11.0%        22.2%        | 
|TERMINAL (d)       |     1/39 (3%)    3/18 (17%)   0/3 (0%)     0/0 (0%)    |15/47 (32%)  8/47 (17%)   4/39 (10%)   8/33 (24%)   | 
|FIRST INCIDENCE    |     729 (T)      600          502          359         |729 (T)      669          370          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **  |P=0.519N     P=0.259N     P=0.067N     P=0.460      | 
|POLY 3             |     P<0.001 **   P=0.066      P<0.001 **   P<0.001 **  |P=0.219N     P=0.279N     P=0.031N*    P=0.387N     | 
|POLY 1.5           |     P<0.001 **   P=0.081      P<0.001 **   P<0.001 **  |P=0.203N     P=0.275N     P=0.028N*    P=0.359N     | 
|POLY 6             |     P<0.001 **   P=0.049 *    P<0.001 **   P<0.001 **  |P=0.249N     P=0.280N     P=0.036N*    P=0.435N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.066      P=0.009 **   P<0.001 **  |P=0.236N     P=0.294N     P=0.031N*    P=0.531N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.103      P=0.002 **   P<0.001 **  |P=0.188N     P=0.269N     P=0.026N*    P=0.331N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    7/60 (12%)   12/60 (20%)  6/60 (10%)  |6/60 (10%)   9/59 (15%)   11/60 (18%)  28/60 (47%)  | 
|POLY-3 RATE (b)    |     5/53.85      7/45.16      12/38.87     6/24.76     |6/56.86      9/54.87      11/53.92     28/54.73     | 
|POLY-3 PERCENT (g) |     9.3%         15.5%        30.9%        24.2%       |10.6%        16.4%        20.4%        51.2%        | 
|TERMINAL (d)       |     5/39 (13%)   4/18 (22%)   1/3 (33%)    0/0 (0%)    |6/47 (13%)   9/47 (19%)   9/39 (23%)   18/33 (55%)  | 
|FIRST INCIDENCE    |     729 (T)      600          523          519         |729 (T)      729 (T)      706          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.062      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.288      P=0.073      P<0.001 **   | 
|POLY 3             |     P=0.007 **   P=0.264      P=0.008 **   P=0.103     |P<0.001 **   P=0.265      P=0.119      P<0.001 **   | 
|POLY 1.5           |     P=0.053      P=0.313      P=0.020 *    P=0.237     |P<0.001 **   P=0.271      P=0.131      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.201      P=0.002 **   P=0.031 *   |P<0.001 **   P=0.259      P=0.106      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.009 **   P=0.193      P=0.012 *    P=0.066     |P<0.001 **   P=0.288      P=0.079      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.305      P=0.381      P=0.057      P=0.500     |P<0.001 **   P=0.279      P=0.148      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    4/60 (7%)    6/60 (10%)   6/60 (10%)  |0/60 (0%)    1/59 (2%)    3/60 (5%)    5/60 (8%)    | 
|POLY-3 RATE (b)    |     3/54.55      4/44.97      6/36.79      6/24.93     |0/56.86      1/54.87      3/54.61      5/53.90      | 
|POLY-3 PERCENT (g) |     5.5%         8.9%         16.3%        24.1%       |0.0%         1.8%         5.5%         9.3%         | 
|TERMINAL (d)       |     1/39 (3%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    2/39 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     537          603          581          421         |---          729 (T)      370          665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.260      P=0.011 *    P<0.001 **  |P=0.003 **   P=0.500      P=0.102      P=0.018 *    | 
|POLY 3             |     P=0.013 *    P=0.397      P=0.096      P=0.034 *   |P=0.006 **   P=0.493      P=0.113      P=0.027 *    | 
|POLY 1.5           |     P=0.040 *    P=0.442      P=0.147      P=0.090     |P=0.007 **   P=0.494      P=0.116      P=0.029 *    | 
|POLY 6             |     P=0.003 **   P=0.336      P=0.050      P=0.010 *   |P=0.005 **   P=0.491      P=0.108      P=0.024 *    | 
|LOGISTIC REGRESSION|     P=0.073      P=0.549      P=0.227      P=0.397     |P=0.009 **   P=0.500      P=0.156      P=0.035 *    | 
|COCH-ARM / FISHERS |     P=0.150      P=0.500      P=0.245      P=0.245     |P=0.008 **   P=0.496      P=0.122      P=0.029 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Regeneration Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |1/60 (2%)    2/59 (3%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      0/21.46     |1/56.88      2/54.96      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |1.8%         3.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |726          708          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.211N     P=0.493      P=0.541N     P=0.575N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.169N     P=0.488      P=0.511N     P=0.513N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.491      P=0.507N     P=0.507N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.177N     P=0.486      P=0.518N     P=0.523N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.177N     P=0.487      P=0.529N     P=0.554N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.157N     P=0.494      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     53/60 (88%)  37/60 (62%)  7/60 (12%)   0/60 (0%)   |7/60 (12%)   2/59 (3%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     53/58.86     37/50.92     7/36.67      0/21.46     |7/56.90      2/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     90.1%        72.7%        19.1%        0.0%        |12.3%        3.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     35/39 (90%)  16/18 (89%)  1/3 (33%)    0/0 (0%)    |5/47 (11%)   2/47 (4%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     441          428          519          ---         |722          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.224N     P=0.070      P=0.266N     P=0.169N    |P=0.002N**   P=0.087N     P=0.020N*    P=0.031N*    | 
|POLY 3             |     P<0.001N**   P=0.008N**   P<0.001N**   P<0.001N**  |P<0.001N**   P=0.090N     P=0.010N*    P=0.011N*    | 
|POLY 1.5           |     P<0.001N**   P=0.002N**   P<0.001N**   P<0.001N**  |P<0.001N**   P=0.088N     P=0.009N**   P=0.009N**   | 
|POLY 6             |     P<0.001N**   P=0.049N*    P<0.001N**   P<0.001N**  |P<0.001N**   P=0.092N     P=0.012N*    P=0.013N*    | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.013N*    P<0.001N**   P<0.001N**  |P=0.002N**   P=0.092N     P=0.017N*    P=0.025N*    | 
|COCH-ARM / FISHERS |     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P<0.001N**   P=0.085N     P=0.006N**   P=0.006N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    3/60 (5%)    8/60 (13%)   5/60 (8%)   |3/60 (5%)    0/59 (0%)    2/60 (3%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     1/53.86      3/44.97      8/37.93      5/24.77     |3/57.16      0/54.87      2/54.05      2/53.92      | 
|POLY-3 PERCENT (g) |     1.9%         6.7%         21.1%        20.2%       |5.3%         0.0%         3.7%         3.7%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     727          621          515          396         |674          ---          672          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.154      P<0.001 **   P=0.003 **  |P=0.561      P=0.131N     P=0.553N     P=0.579N     | 
|POLY 3             |     P<0.001 **   P=0.245      P=0.003 **   P=0.016 *   |P=0.531N     P=0.127N     P=0.525N     P=0.526N     | 
|POLY 1.5           |     P=0.005 **   P=0.271      P=0.007 **   P=0.038 *   |P=0.524N     P=0.125N     P=0.515N     P=0.513N     | 
|POLY 6             |     P<0.001 **   P=0.211      P<0.001 **   P=0.006 **  |P=0.543N     P=0.129N     P=0.539N     P=0.548N     | 
|LOGISTIC REGRESSION|     P=0.059      P=0.317      P=0.018 *    P=0.401     |P=0.495N     P=0.122N     P=0.490N     P=0.471N     | 
|COCH-ARM / FISHERS |     P=0.044 *    P=0.309      P=0.016 *    P=0.103     |P=0.517N     P=0.125N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    2/60 (3%)    1/60 (2%)    1/60 (2%)   |4/60 (7%)    2/59 (3%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     4/54.62      2/44.73      1/35.16      1/22.27     |4/58.16      2/55.71      1/53.86      0/53.33      | 
|POLY-3 PERCENT (g) |     7.3%         4.5%         2.8%         4.5%        |6.9%         3.6%         1.9%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     640          499          616          419         |453          531          698          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.499      P=0.586N     P=0.629N     P=0.530     |P=0.031N*    P=0.352N     P=0.217N     P=0.088N     | 
|POLY 3             |     P=0.260N     P=0.433N     P=0.340N     P=0.518N    |P=0.025N*    P=0.358N     P=0.204N     P=0.073N     | 
|POLY 1.5           |     P=0.159N     P=0.389N     P=0.263N     P=0.350N    |P=0.023N*    P=0.353N     P=0.194N     P=0.068N     | 
|POLY 6             |     P=0.425N     P=0.500N     P=0.462N     P=0.592     |P=0.029N*    P=0.363N     P=0.218N     P=0.083N     | 
|LOGISTIC REGRESSION|     P=0.054N     P=0.271N     P=0.221N     P=0.163N    |P=0.013N*    P=0.290N     P=0.124N     P=0.048N*    | 
|COCH-ARM / FISHERS |     P=0.082N     P=0.340N     P=0.182N     P=0.182N    |P=0.022N*    P=0.348N     P=0.182N     P=0.059N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    0/60 (0%)    1/60 (2%)    3/60 (5%)   |3/60 (5%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     4/54.70      0/44.05      1/34.92      3/23.54     |3/57.85      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     7.3%         0.0%         2.9%         12.7%       |5.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     533          ---          691          419         |453          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076      P=0.146N     P=0.719N     P=0.116     |P=0.031N*    P=0.128N     P=0.145N     P=0.155N     | 
|POLY 3             |     P=0.588N     P=0.094N     P=0.344N     P=0.386     |P=0.022N*    P=0.129N     P=0.134N     P=0.135N     | 
|POLY 1.5           |     P=0.546N     P=0.078N     P=0.265N     P=0.572     |P=0.022N*    P=0.127N     P=0.128N     P=0.128N     | 
|POLY 6             |     P=0.594N     P=0.123N     P=0.467N     P=0.203     |P=0.023N*    P=0.132N     P=0.141N     P=0.147N     | 
|LOGISTIC REGRESSION|     P=0.382N     P=0.047N*    P=0.246N     P=0.308N    |P=0.017N*    P=0.105N     P=0.079N     P=0.103N     | 
|COCH-ARM / FISHERS |     P=0.476N     P=0.059N     P=0.182N     P=0.500N    |P=0.024N*    P=0.125N     P=0.122N     P=0.122N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    0/60 (0%)    1/60 (2%)    0/60 (0%)   |2/60 (3%)    2/60 (3%)    2/60 (3%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     3/54.48      0/44.05      1/35.24      0/21.46     |2/56.95      2/55.69      2/54.37      1/53.33      | 
|POLY-3 PERCENT (g) |     5.5%         0.0%         2.8%         0.0%        |3.5%         3.6%         3.7%         1.9%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    2/47 (4%)    1/39 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     537          ---          589          ---         |707          729 (T)      525          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.405N     P=0.222N     P=0.723      P=0.699N    |P=0.482N     P=0.688      P=0.646      P=0.611N     | 
|POLY 3             |     P=0.154N     P=0.162N     P=0.472N     P=0.354N    |P=0.393N     P=0.685      P=0.677      P=0.523N     | 
|POLY 1.5           |     P=0.100N     P=0.142N     P=0.397N     P=0.229N    |P=0.381N     P=0.689      P=0.684      P=0.512N     | 
|POLY 6             |     P=0.252N     P=0.196N     P=0.577N     P=0.522N    |P=0.413N     P=0.681      P=0.666      P=0.542N     | 
|LOGISTIC REGRESSION|     P=0.063N     P=0.095N     P=0.276N     P=0.213N    |P=0.358N     P=0.684      P=0.662N     P=0.558N     | 
|COCH-ARM / FISHERS |     P=0.063N     P=0.122N     P=0.309N     P=0.122N    |P=0.367N     P=0.691N     P=0.691N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/60 (42%)  42/60 (70%)  40/60 (67%)  22/60 (37%) |52/60 (87%)  54/60 (90%)  53/60 (88%)  55/60 (92%)  | 
|POLY-3 RATE (b)    |     25/56.21     42/54.40     40/48.45     22/34.97    |52/58.74     54/58.37     53/57.43     55/58.34     | 
|POLY-3 PERCENT (g) |     44.5%        77.2%        82.6%        62.9%       |88.5%        92.5%        92.3%        94.3%        | 
|TERMINAL (d)       |     16/39 (41%)  12/18 (67%)  2/3 (67%)    0/0 (0%)    |42/47 (89%)  45/47 (96%)  38/39 (97%)  33/33 (100%) | 
|FIRST INCIDENCE    |     537          465          483          391         |453          495          370          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.393      P=0.053      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P=0.065     |P=0.155      P=0.331      P=0.346      P=0.205      | 
|POLY 1.5           |     P=0.086      P<0.001 **   P<0.001 **   P=0.306     |P=0.201      P=0.355      P=0.414      P=0.240      | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P=0.004 **  |P=0.100      P=0.305      P=0.263      P=0.155      | 
|LOGISTIC REGRESSION|     P=0.043 *    P<0.001 **   P<0.001 **   P=0.392     |P=0.150      P=0.325      P=0.339      P=0.187      | 
|COCH-ARM / FISHERS |     P=0.224N     P=0.002 **   P=0.005 **   P=0.354N    |P=0.259      P=0.389      P=0.500      P=0.279      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    8/60 (13%)   3/60 (5%)    7/60 (12%)  |6/60 (10%)   14/60 (23%)  16/60 (27%)  9/60 (15%)   | 
|POLY-3 RATE (b)    |     2/53.86      8/44.77      3/35.85      7/26.13     |6/57.38      14/55.77     16/54.23     9/54.15      | 
|POLY-3 PERCENT (g) |     3.7%         17.9%        8.4%         26.8%       |10.5%        25.1%        29.5%        16.6%        | 
|TERMINAL (d)       |     1/39 (3%)    4/18 (22%)   0/3 (0%)     0/0 (0%)    |3/47 (6%)    13/47 (28%)  14/39 (36%)  5/33 (15%)   | 
|FIRST INCIDENCE    |     727          589          589          421         |620          708          656          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.003 **   P=0.062      P<0.001 **  |P=0.063      P=0.044 *    P=0.006 **   P=0.139      | 
|POLY 3             |     P=0.014 *    P=0.022 *    P=0.325      P=0.007 **  |P=0.198      P=0.035 *    P=0.010 *    P=0.250      | 
|POLY 1.5           |     P=0.047 *    P=0.032 *    P=0.398      P=0.022 *   |P=0.229      P=0.038 *    P=0.012 *    P=0.270      | 
|POLY 6             |     P=0.002 **   P=0.013 *    P=0.236      P<0.001 **  |P=0.152      P=0.031 *    P=0.007 **   P=0.219      | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.009 **   P=0.365      P=0.341     |P=0.184      P=0.037 *    P=0.011 *    P=0.286      | 
|COCH-ARM / FISHERS |     P=0.172      P=0.047 *    P=0.500      P=0.081     |P=0.268      P=0.042 *    P=0.016 *    P=0.291      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/58 (3%)    0/59 (0%)    0/58 (0%)    0/59 (0%)   |1/60 (2%)    3/60 (5%)    0/59 (0%)    4/59 (7%)    | 
|POLY-3 RATE (b)    |     2/51.94      0/43.05      0/33.39      0/21.19     |1/56.89      3/55.69      0/52.74      4/52.68      | 
|POLY-3 PERCENT (g) |     3.9%         0.0%         0.0%         0.0%        |1.8%         5.4%         0.0%         7.6%         | 
|TERMINAL (d)       |     2/38 (5%)    0/17 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    3/47 (6%)    0/38 (0%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |722          729 (T)      ---          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.428N     P=0.835N     P=1.000N    |P=0.106      P=0.303      P=0.546N     P=0.104      | 
|POLY 3             |     P=0.102N     P=0.282N     P=0.347N     P=0.458N    |P=0.173      P=0.298      P=0.515N     P=0.157      | 
|POLY 1.5           |     P=0.078N     P=0.259N     P=0.296N     P=0.350N    |P=0.181      P=0.302      P=0.510N     P=0.166      | 
|POLY 6             |     P=0.149N     P=0.317N     P=0.425N     P=0.589N    |P=0.160      P=0.295      P=0.522N     P=0.144      | 
|LOGISTIC REGRESSION|     P=0.407N     (e)          (e)          (e)         |P=0.165      P=0.291      P=0.523N     P=0.166      | 
|COCH-ARM / FISHERS |     P=0.067N     P=0.244N     P=0.248N     P=0.244N    |P=0.192      P=0.309      P=0.504N     P=0.177      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/58 (3%)    2/59 (3%)    1/58 (2%)    1/59 (2%)   |4/60 (7%)    4/60 (7%)    1/59 (2%)    4/59 (7%)    | 
|POLY-3 RATE (b)    |     2/52.72      2/43.94      1/33.39      1/21.84     |4/56.86      4/56.01      1/52.96      4/52.50      | 
|POLY-3 PERCENT (g) |     3.8%         4.6%         3.0%         4.6%        |7.0%         7.1%         1.9%         7.6%         | 
|TERMINAL (d)       |     1/38 (3%)    0/17 (0%)    1/3 (33%)    0/0 (0%)    |4/47 (9%)    2/47 (4%)    0/38 (0%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     441          555          729 (T)      512         |729 (T)      669          672          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.572      P=0.577      P=0.657     |P=0.505      P=0.636      P=0.243N     P=0.440      | 
|POLY 3             |     P=0.608      P=0.626      P=0.650N     P=0.659     |P=0.469N     P=0.634      P=0.202N     P=0.598      | 
|POLY 1.5           |     P=0.461N     P=0.659      P=0.587N     P=0.647N    |P=0.455N     P=0.637      P=0.195N     P=0.615      | 
|POLY 6             |     P=0.482      P=0.577      P=0.690      P=0.497     |P=0.491N     P=0.631      P=0.212N     P=0.569      | 
|LOGISTIC REGRESSION|     P=0.199N     P=0.481N     P=0.461N     P=0.202N    |P=0.480N     P=0.633      P=0.204N     P=0.516      | 
|COCH-ARM / FISHERS |     P=0.297N     P=0.684N     P=0.500N     P=0.494N    |P=0.439N     P=0.641N     P=0.187N     P=0.632      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/58 (5%)    4/59 (7%)    3/58 (5%)    2/59 (3%)   |3/60 (5%)    5/60 (8%)    6/59 (10%)   15/59 (25%)  | 
|POLY-3 RATE (b)    |     3/52.26      4/44.04      3/35.12      2/22.54     |3/56.95      5/55.69      6/53.05      15/54.29     | 
|POLY-3 PERCENT (g) |     5.7%         9.1%         8.5%         8.9%        |5.3%         9.0%         11.3%        27.6%        | 
|TERMINAL (d)       |     2/38 (5%)    2/17 (12%)   0/3 (0%)     0/0 (0%)    |2/47 (4%)    5/47 (11%)   4/38 (11%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     640          534          391          359         |707          729 (T)      672          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.038 *    P=0.216      P=0.212      P=0.093     |P<0.001 **   P=0.354      P=0.170      P<0.001 **   | 
|POLY 3             |     P=0.351      P=0.408      P=0.471      P=0.502     |P<0.001 **   P=0.345      P=0.210      P<0.001 **   | 
|POLY 1.5           |     P=0.535      P=0.453      P=0.556      P=0.664     |P<0.001 **   P=0.351      P=0.221      P<0.001 **   | 
|POLY 6             |     P=0.173      P=0.344      P=0.354      P=0.314     |P<0.001 **   P=0.339      P=0.197      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.249N     P=0.501      P=0.543N     P=0.566N    |P<0.001 **   P=0.336      P=0.204      P=0.002 **   | 
|COCH-ARM / FISHERS |     P=0.340N     P=0.510      P=0.660N     P=0.492N    |P<0.001 **   P=0.359      P=0.237      P=0.002 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/58 (16%)   2/59 (3%)    6/58 (10%)   12/59 (20%) |31/60 (52%)  33/60 (55%)  30/59 (51%)  30/59 (51%)  | 
|POLY-3 RATE (b)    |     9/52.29      2/43.72      6/35.59      12/29.09    |31/57.80     33/58.76     30/56.46     30/54.77     | 
|POLY-3 PERCENT (g) |     17.2%        4.6%         16.9%        41.3%       |53.6%        56.2%        53.1%        54.8%        | 
|TERMINAL (d)       |     6/38 (16%)   0/17 (0%)    2/3 (67%)    0/0 (0%)    |28/47 (60%)  25/47 (53%)  19/38 (50%)  20/32 (63%)  | 
|FIRST INCIDENCE    |     673          616          483          404         |453          429          432          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.211N     P=0.019 *    P<0.001 **  |P=0.074      P=0.421      P=0.275      P=0.073      | 
|POLY 3             |     P=0.024 *    P=0.052N     P=0.594N     P=0.021 *   |P=0.520      P=0.465      P=0.554N     P=0.527      | 
|POLY 1.5           |     P=0.051      P=0.038N*    P=0.458N     P=0.092     |P=0.488N     P=0.451      P=0.548N     P=0.565      | 
|POLY 6             |     P=0.008 **   P=0.082N     P=0.432      P=0.002 **  |P=0.454      P=0.482      P=0.562N     P=0.465      | 
|LOGISTIC REGRESSION|     P=0.136      P=0.069N     P=0.609N     P=0.366     |P=0.444N     P=0.430      P=0.545N     P=0.506      | 
|COCH-ARM / FISHERS |     P=0.131      P=0.025N*    P=0.291N     P=0.331     |P=0.435N     P=0.427      P=0.537N     P=0.537N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    3/60 (5%)    1/60 (2%)    2/60 (3%)   |1/60 (2%)    1/60 (2%)    1/60 (2%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     2/54.21      3/45.38      1/35.03      2/22.93     |1/56.86      1/55.69      1/53.74      3/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         6.6%         2.9%         8.7%        |1.8%         1.8%         1.9%         5.6%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    1/39 (3%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     631          378          658          359         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.108      P=0.326      P=0.591      P=0.174     |P=0.094      P=0.761      P=0.720      P=0.189      | 
|POLY 3             |     P=0.403      P=0.420      P=0.644N     P=0.384     |P=0.160      P=0.756      P=0.748      P=0.283      | 
|POLY 1.5           |     P=0.521      P=0.456      P=0.583N     P=0.524     |P=0.167      P=0.758      P=0.753      P=0.294      | 
|POLY 6             |     P=0.285      P=0.368      P=0.698      P=0.242     |P=0.149      P=0.754      P=0.741      P=0.265      | 
|LOGISTIC REGRESSION|     P=0.206N     P=0.686N     P=0.630N     P=0.483N    |P=0.094      P=0.761      P=0.720      P=0.189      | 
|COCH-ARM / FISHERS |     P=0.452N     P=0.500      P=0.500N     P=0.691N    |P=0.173      P=0.752N     P=0.752N     P=0.309      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/60 (10%)   9/60 (15%)   3/60 (5%)    8/60 (13%)  |6/60 (10%)   1/60 (2%)    1/60 (2%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     6/54.93      9/46.72      3/35.57      8/26.15     |6/57.66      1/55.69      1/53.74      3/53.33      | 
|POLY-3 PERCENT (g) |     10.9%        19.3%        8.4%         30.6%       |10.4%        1.8%         1.9%         5.6%         | 
|TERMINAL (d)       |     1/39 (3%)    3/18 (17%)   0/3 (0%)     0/0 (0%)    |3/47 (6%)    1/47 (2%)    1/39 (3%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     631          378          637          359         |453          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.064      P=0.358      P<0.001 **  |P=0.277N     P=0.065N     P=0.096N     P=0.419N     | 
|POLY 3             |     P=0.107      P=0.184      P=0.490N     P=0.045 *   |P=0.168N     P=0.064N     P=0.070N     P=0.284N     | 
|POLY 1.5           |     P=0.246      P=0.230      P=0.376N     P=0.139     |P=0.163N     P=0.061N     P=0.065N     P=0.265N     | 
|POLY 6             |     P=0.026 *    P=0.127      P=0.615      P=0.009 **  |P=0.176N     P=0.066N     P=0.077N     P=0.315N     | 
|LOGISTIC REGRESSION|     P=0.462      P=0.415      P=0.412N     P=0.445     |P=0.158N     P=0.054N     P=0.050N     P=0.229N     | 
|COCH-ARM / FISHERS |     P=0.521      P=0.291      P=0.245N     P=0.389     |P=0.158N     P=0.057N     P=0.057N     P=0.245N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    0/60 (0%)    2/59 (3%)    1/58 (2%)   |0/59 (0%)    0/58 (0%)    0/59 (0%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     1/54.18      0/44.05      2/35.06      1/21.62     |0/55.98      0/53.87      0/52.74      0/52.53      | 
|POLY-3 PERCENT (g) |     1.9%         0.0%         5.7%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/46 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     640          ---          603          463         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.086      P=0.594N     P=0.265      P=0.481     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.251      P=0.541N     P=0.356      P=0.537     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.307      P=0.523N     P=0.414      P=0.640     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.223      P=0.567N     P=0.283      P=0.414     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.560      P=0.450N     P=0.574      P=0.649N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.422      P=0.500N     P=0.494      P=0.744     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    6/60 (10%)   3/59 (5%)    2/58 (3%)   |5/59 (8%)    3/58 (5%)    4/59 (7%)    5/59 (8%)    | 
|POLY-3 RATE (b)    |     2/54.46      6/47.12      3/34.76      2/22.29     |5/55.98      3/54.10      4/53.37      5/52.62      | 
|POLY-3 PERCENT (g) |     3.7%         12.7%        8.6%         9.0%        |8.9%         5.6%         7.5%         9.5%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    1/3 (33%)    0/0 (0%)    |5/47 (11%)   2/46 (4%)    3/38 (8%)    4/33 (12%)   | 
|FIRST INCIDENCE    |     537          378          603          439         |729 (T)      669          525          708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055      P=0.072      P=0.048 *    P=0.277     |P=0.295      P=0.369N     P=0.617N     P=0.407      | 
|POLY 3             |     P=0.198      P=0.093      P=0.310      P=0.374     |P=0.461      P=0.376N     P=0.530N     P=0.590      | 
|POLY 1.5           |     P=0.401      P=0.111      P=0.385      P=0.510     |P=0.480      P=0.373N     P=0.517N     P=0.609      | 
|POLY 6             |     P=0.054      P=0.071      P=0.219      P=0.237     |P=0.431      P=0.380N     P=0.548N     P=0.557      | 
|LOGISTIC REGRESSION|     P=0.158N     P=0.422      P=0.391      P=0.423N    |P=0.467      P=0.380N     P=0.506N     P=0.441      | 
|COCH-ARM / FISHERS |     P=0.410N     P=0.136      P=0.492      P=0.678     |P=0.499      P=0.368N     P=0.500N     P=0.629N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    3/60 (5%)    0/59 (0%)    0/58 (0%)   |0/59 (0%)    4/58 (7%)    1/59 (2%)    3/59 (5%)    | 
|POLY-3 RATE (b)    |     3/54.18      3/44.52      0/34.26      0/20.87     |0/55.98      4/54.19      1/52.74      3/53.10      | 
|POLY-3 PERCENT (g) |     5.5%         6.7%         0.0%         0.0%        |0.0%         7.4%         1.9%         5.7%         | 
|TERMINAL (d)       |     2/39 (5%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    2/46 (4%)    1/38 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     640          641          ---          ---         |---          669          729 (T)      639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.576N     P=0.356      P=0.551N     P=0.993N    |P=0.142      P=0.062      P=0.458      P=0.093      | 
|POLY 3             |     P=0.141N     P=0.568      P=0.223N     P=0.359N    |P=0.192      P=0.057      P=0.488      P=0.110      | 
|POLY 1.5           |     P=0.064N     P=0.611      P=0.174N     P=0.236N    |P=0.204      P=0.058      P=0.493      P=0.115      | 
|POLY 6             |     P=0.351N     P=0.506      P=0.308N     P=0.524N    |P=0.175      P=0.057      P=0.481      P=0.103      | 
|LOGISTIC REGRESSION|     P=0.182N     P=0.579      P=0.254N     P=0.647N    |P=0.220      P=0.061      P=0.458      P=0.132      | 
|COCH-ARM / FISHERS |     P=0.025N*    P=0.660N     P=0.125N     P=0.128N    |P=0.217      P=0.057      P=0.500      P=0.122      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/57 (5%)    10/47 (21%)  1/46 (2%)    1/43 (2%)   |40/60 (67%)  30/60 (50%)  29/59 (49%)  24/60 (40%)  | 
|POLY-3 RATE (b)    |     3/53.07      10/37.48     1/25.69      1/16.32     |40/58.61     30/57.85     29/56.30     24/55.71     | 
|POLY-3 PERCENT (g) |     5.7%         26.7%        3.9%         6.1%        |68.3%        51.9%        51.5%        43.1%        | 
|TERMINAL (d)       |     1/39 (3%)    2/16 (13%)   0/2 (0%)     0/0 (0%)    |32/47 (68%)  24/47 (51%)  19/39 (49%)  15/33 (46%)  | 
|FIRST INCIDENCE    |     441          378          676          655         |401          505          370          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126      P=0.004 **   P=0.708N     P=0.506     |P=0.204N     P=0.075N     P=0.246N     P=0.192N     | 
|POLY 3             |     P=0.390      P=0.005 **   P=0.577N     P=0.664     |P=0.005N**   P=0.050N     P=0.047N*    P=0.004N**   | 
|POLY 1.5           |     P=0.384N     P=0.008 **   P=0.496N     P=0.586N    |P=0.004N**   P=0.049N*    P=0.042N*    P=0.003N**   | 
|POLY 6             |     P=0.058      P=0.003 **   P=0.678N     P=0.504     |P=0.009N**   P=0.052N     P=0.056N     P=0.007N**   | 
|LOGISTIC REGRESSION|     P=0.153N     P=0.049 *    P=0.242N     P=0.293N    |P=0.004N**   P=0.050N     P=0.042N*    P=0.004N**   | 
|COCH-ARM / FISHERS |     P=0.100N     P=0.015 *    P=0.394N     P=0.422N    |P=0.003N**   P=0.048N*    P=0.040N*    P=0.003N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/57 (4%)    0/47 (0%)    0/46 (0%)    0/43 (0%)   |0/60 (0%)    1/60 (2%)    0/59 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/51.98      0/34.89      0/25.48      0/16.05     |0/56.86      1/55.69      0/53.53      0/53.33      | 
|POLY-3 PERCENT (g) |     3.9%         0.0%         0.0%         0.0%        |0.0%         1.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/16 (0%)    0/2 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     727          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.423N     P=0.431N     P=0.874N     P=1.000N    |P=0.573N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.145N     P=0.333N     P=0.413N     P=0.515N    |P=0.527N     P=0.496      (e)          (e)          | 
|POLY 1.5           |     P=0.109N     P=0.310N     P=0.356N     P=0.419N    |P=0.523N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.210N     P=0.366N     P=0.493N     P=0.622N    |P=0.533N     P=0.494      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.412N     P=0.425N     P=0.870N     (e)         |(e)          P=0.500      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.298N     P=0.304N     P=0.322N    |P=0.517N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/57 (11%)   2/47 (4%)    2/46 (4%)    2/43 (5%)   |14/60 (23%)  36/60 (60%)  30/59 (51%)  19/60 (32%)  | 
|POLY-3 RATE (b)    |     6/53.30      2/35.18      2/26.32      2/17.40     |14/56.90     36/57.70     30/55.17     19/54.26     | 
|POLY-3 PERCENT (g) |     11.3%        5.7%         7.6%         11.5%       |24.6%        62.4%        54.4%        35.0%        | 
|TERMINAL (d)       |     2/39 (5%)    1/16 (6%)    0/2 (0%)     0/0 (0%)    |13/47 (28%)  29/47 (62%)  23/39 (59%)  12/33 (36%)  | 
|FIRST INCIDENCE    |     533          650          597          419         |719          495          523          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.221      P=0.377N     P=0.633      P=0.383     |P=0.033 *    P<0.001 **   P<0.001 **   P=0.031 *    | 
|POLY 3             |     P=0.422N     P=0.307N     P=0.458N     P=0.631     |P=0.250      P<0.001 **   P<0.001 **   P=0.159      | 
|POLY 1.5           |     P=0.281N     P=0.261N     P=0.346N     P=0.467N    |P=0.304      P<0.001 **   P<0.001 **   P=0.181      | 
|POLY 6             |     P=0.594      P=0.376N     P=0.610N     P=0.412     |P=0.174      P<0.001 **   P<0.001 **   P=0.127      | 
|LOGISTIC REGRESSION|     P=0.129N     P=0.152N     P=0.158N     P=0.080N    |P=0.258      P<0.001 **   P<0.001 **   P=0.081      | 
|COCH-ARM / FISHERS |     P=0.147N     P=0.207N     P=0.216N     P=0.246N    |P=0.373      P<0.001 **   P=0.002 **   P=0.207      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/16 (19%)   0/6 (0%)     0/5 (0%)     3/4 (75%)   |2/9 (22%)    0/1 (0%)     1/3 (33%)    1/3 (33%)    | 
|POLY-3 RATE (b)    |     3/14.77      0/3.54       0/3.58       3/3.26      |2/8.24       0/1.00       1/3.00       1/3.00       | 
|POLY-3 PERCENT (g) |     20.3%        0.0%         0.0%         92.1%       |24.3%        0.0%         33.3%        33.3%        | 
|TERMINAL (d)       |     2/11 (18%)   0/0 (0%)     0/0 (0%)     0/0 (0%)    |1/7 (14%)    0/1 (0%)     1/3 (33%)    1/3 (33%)    | 
|FIRST INCIDENCE    |     586          ---          ---          404         |620          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.536N     P=0.590N     P=0.064     |P=0.556      P=0.421N     P=0.717N     P=0.735N     | 
|POLY 3             |     P=0.026 *    P=0.457N     P=0.451N     P=0.022 *   |P=0.463      P=0.754N     P=0.666      P=0.666      | 
|POLY 1.5           |     P=0.039 *    P=0.406N     P=0.415N     P=0.027 *   |P=0.451      P=0.758N     P=0.657      P=0.657      | 
|POLY 6             |     P=0.013 *    P=0.519N     P=0.514N     P=0.019 *   |P=0.471      P=0.751N     P=0.673      P=0.673      | 
|LOGISTIC REGRESSION|     P=0.330      P=0.359N     P=0.350N     P=0.648     |P=0.405      P=0.808N     P=0.645      P=0.645      | 
|COCH-ARM / FISHERS |     P=0.086      P=0.364N     P=0.421N     P=0.061     |P=0.420      P=0.800N     P=0.618      P=0.618      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/16 (19%)   0/6 (0%)     0/5 (0%)     0/4 (0%)    |0/9 (0%)     0/1 (0%)     0/3 (0%)     0/3 (0%)     | 
|POLY-3 RATE (b)    |     3/14.29      0/3.54       0/3.58       0/1.11      |0/7.86       0/1.00       0/3.00       0/3.00       | 
|POLY-3 PERCENT (g) |     21.0%        0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/11 (27%)   0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/7 (0%)     0/1 (0%)     0/3 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.201N     P=0.448N     P=0.441N     P=0.662N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.158N     P=0.400N     P=0.410N     P=0.580N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.271N     P=0.507N     P=0.502N     P=0.731N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=1.000N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.122N     P=0.364N     P=0.421N     P=0.491N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/16 (81%)  3/6 (50%)    5/5 (100%)   1/4 (25%)   |7/9 (78%)    1/1 (100%)   2/3 (67%)    0/3 (0%)     | 
|POLY-3 RATE (b)    |     13/16.00     3/4.45       5/5.00       1/1.86      |7/8.62       1/1.00       2/3.00       0/3.00       | 
|POLY-3 PERCENT (g) |     81.3%        67.5%        100.0%       53.9%       |81.3%        100.0%       66.7%        0.0%         | 
|TERMINAL (d)       |     8/11 (73%)   0/0 (0%)     0/0 (0%)     0/0 (0%)    |6/7 (86%)    1/1 (100%)   2/3 (67%)    0/3 (0%)     | 
|FIRST INCIDENCE    |     537          615          597          463         |453          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060      P=0.587N     P=0.086      P=0.579     |P=0.008N**   P=0.594N     P=0.318N     P=0.024N*    | 
|POLY 3             |     P=0.510      P=0.509N     P=0.380      P=0.525N    |P=0.007N**   P=0.822      P=0.608N     P=0.007N**   | 
|POLY 1.5           |     P=0.445N     P=0.376N     P=0.380      P=0.264N    |P=0.010N*    P=0.796      P=0.622N     P=0.010N*    | 
|POLY 6             |     P=0.332      P=0.611N     P=0.380      P=0.752N    |P=0.004N**   P=0.856      P=0.582N     P=0.003N**   | 
|LOGISTIC REGRESSION|     P=0.527N     P=0.344N     (e)          P=0.251N    |P=0.028N*    P=0.808      P=0.645N     P=0.051N     | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.176N     P=0.421      P=0.061N    |P=0.028N*    P=0.800      P=0.618N     P=0.045N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/60 (15%)   13/60 (22%)  10/60 (17%)  11/60 (18%) |2/60 (3%)    0/60 (0%)    0/60 (0%)    7/60 (12%)   | 
|POLY-3 RATE (b)    |     9/54.19      13/46.28     10/37.61     11/27.62    |2/56.86      0/55.69      0/53.74      7/53.42      | 
|POLY-3 PERCENT (g) |     16.6%        28.1%        26.6%        39.8%       |3.5%         0.0%         0.0%         13.1%        | 
|TERMINAL (d)       |     6/39 (15%)   5/18 (28%)   0/3 (0%)     0/0 (0%)    |2/47 (4%)    0/47 (0%)    0/39 (0%)    6/33 (18%)   | 
|FIRST INCIDENCE    |     691          567          299          439         |729 (T)      ---          ---          708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P=0.003 **   P=0.239N     P=0.280N     P=0.026 *    | 
|POLY 3             |     P=0.022 *    P=0.124      P=0.189      P=0.028 *   |P=0.010 *    P=0.242N     P=0.250N     P=0.067      | 
|POLY 1.5           |     P=0.116      P=0.169      P=0.310      P=0.118     |P=0.010 *    P=0.240N     P=0.245N     P=0.074      | 
|POLY 6             |     P<0.001 **   P=0.077      P=0.077      P=0.003 **  |P=0.009 **   P=0.245N     P=0.258N     P=0.056      | 
|LOGISTIC REGRESSION|     P=0.013 *    P=0.090      P=0.166      P=0.032 *   |P=0.004 **   (e)          (e)          P=0.029 *    | 
|COCH-ARM / FISHERS |     P=0.446      P=0.240      P=0.500      P=0.404     |P=0.012 *    P=0.248N     P=0.248N     P=0.081      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      2/36.63      0/21.46     |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          299          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.428      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.173      (e)          P=0.165      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.264      (e)          P=0.195      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.101      (e)          P=0.129      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.429      (e)          P=0.248      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/60 (15%)   9/60 (15%)   8/60 (13%)   9/60 (15%)  |2/60 (3%)    1/60 (2%)    2/60 (3%)    8/60 (13%)   | 
|POLY-3 RATE (b)    |     9/54.34      9/45.95      8/36.44      9/26.51     |2/56.86      1/55.69      2/53.96      8/54.10      | 
|POLY-3 PERCENT (g) |     16.6%        19.6%        22.0%        34.0%       |3.5%         1.8%         3.7%         14.8%        | 
|TERMINAL (d)       |     6/39 (15%)   3/18 (17%)   0/3 (0%)     0/0 (0%)    |2/47 (4%)    1/47 (2%)    1/39 (3%)    5/33 (15%)   | 
|FIRST INCIDENCE    |     663          615          576          432         |729 (T)      729 (T)      672          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.138      P<0.001 **   P<0.001 **  |P=0.003 **   P=0.500N     P=0.634      P=0.018 *    | 
|POLY 3             |     P=0.080      P=0.448      P=0.359      P=0.088     |P=0.007 **   P=0.507N     P=0.674      P=0.039 *    | 
|POLY 1.5           |     P=0.231      P=0.515      P=0.509      P=0.259     |P=0.007 **   P=0.504N     P=0.682      P=0.043 *    | 
|POLY 6             |     P=0.013 *    P=0.355      P=0.186      P=0.016 *   |P=0.006 **   P=0.511N     P=0.664      P=0.033 *    | 
|LOGISTIC REGRESSION|     P=0.023 *    P=0.439      P=0.131      P=0.109     |P=0.008 **   P=0.500N     P=0.679      P=0.044 *    | 
|COCH-ARM / FISHERS |     P=0.509N     P=0.601N     P=0.500N     P=0.601N    |P=0.009 **   P=0.500N     P=0.691N     P=0.047 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/60 (10%)   5/60 (8%)    7/60 (12%)   8/60 (13%)  |2/60 (3%)    0/60 (0%)    0/60 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     6/54.35      5/44.98      7/36.38      8/25.89     |2/56.86      0/55.69      0/53.74      3/53.42      | 
|POLY-3 PERCENT (g) |     11.0%        11.1%        19.2%        30.9%       |3.5%         0.0%         0.0%         5.6%         | 
|TERMINAL (d)       |     4/39 (10%)   3/18 (17%)   0/3 (0%)     0/0 (0%)    |2/47 (4%)    0/47 (0%)    0/39 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     631          567          576          432         |729 (T)      ---          ---          708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.348      P=0.002 **   P<0.001 **  |P=0.218      P=0.239N     P=0.280N     P=0.353      | 
|POLY 3             |     P=0.028 *    P=0.620      P=0.223      P=0.044 *   |P=0.307      P=0.242N     P=0.250N     P=0.472      | 
|POLY 1.5           |     P=0.082      P=0.572N     P=0.332      P=0.139     |P=0.312      P=0.240N     P=0.245N     P=0.486      | 
|POLY 6             |     P=0.006 **   P=0.537      P=0.113      P=0.008 **  |P=0.301      P=0.245N     P=0.258N     P=0.448      | 
|LOGISTIC REGRESSION|     P=0.014 *    P=0.620N     P=0.133      P=0.144     |P=0.248      (e)          (e)          P=0.393      | 
|COCH-ARM / FISHERS |     P=0.259      P=0.500N     P=0.500      P=0.389     |P=0.317      P=0.248N     P=0.248N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    1/60 (2%)    1/60 (2%)    1/60 (2%)   |0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     2/53.95      1/44.05      1/34.83      1/22.25     |0/56.86      0/55.69      1/53.74      1/53.68      | 
|POLY-3 PERCENT (g) |     3.7%         2.3%         2.9%         4.5%        |0.0%         0.0%         1.9%         1.9%         | 
|TERMINAL (d)       |     1/39 (3%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     705          729 (T)      714          432         |---          ---          729 (T)      632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.088      P=0.725      P=0.401      P=0.460     |P=0.157      (e)          P=0.463      P=0.496      | 
|POLY 3             |     P=0.597N     P=0.570N     P=0.644N     P=0.658     |P=0.175      (e)          P=0.489      P=0.489      | 
|POLY 1.5           |     P=0.486N     P=0.539N     P=0.583N     P=0.650N    |P=0.180      (e)          P=0.493      P=0.494      | 
|POLY 6             |     P=0.575      P=0.614N     P=0.697      P=0.496     |P=0.165      (e)          P=0.482      P=0.479      | 
|LOGISTIC REGRESSION|     P=0.542      P=0.683N     P=0.607      P=0.668N    |P=0.192      (e)          P=0.463      P=0.509      | 
|COCH-ARM / FISHERS |     P=0.359N     P=0.500N     P=0.500N     P=0.500N    |P=0.185      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/60 (0%)    0/59 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |                                                        |0/56.86      0/54.87      0/53.74      2/53.85      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         3.7%         | 
|TERMINAL (d)       |                                                        |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          603          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.046 *    (e)          (e)          P=0.210      | 
|POLY 3             |                                                        |P=0.050      (e)          (e)          P=0.226      | 
|POLY 1.5           |                                                        |P=0.052      (e)          (e)          P=0.232      | 
|POLY 6             |                                                        |P=0.049 *    (e)          (e)          P=0.216      | 
|LOGISTIC REGRESSION|                                                        |P=0.056      (e)          (e)          P=0.252      | 
|COCH-ARM / FISHERS |                                                        |P=0.054      (e)          (e)          P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/60 (15%)   8/59 (14%)   11/60 (18%)  6/60 (10%)   | 
|POLY-3 RATE (b)    |                                                        |9/56.86      8/54.87      11/54.11     6/53.51      | 
|POLY-3 PERCENT (g) |                                                        |15.8%        14.6%        20.3%        11.2%        | 
|TERMINAL (d)       |                                                        |9/47 (19%)   8/47 (17%)   9/39 (23%)   4/33 (12%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      656          706          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.430      P=0.500N     P=0.247      P=0.558N     | 
|POLY 3             |                                                        |P=0.379N     P=0.532N     P=0.356      P=0.334N     | 
|POLY 1.5           |                                                        |P=0.351N     P=0.525N     P=0.376      P=0.313N     | 
|POLY 6             |                                                        |P=0.429N     P=0.539N     P=0.332      P=0.372N     | 
|LOGISTIC REGRESSION|                                                        |P=0.525N     P=0.500N     P=0.296      P=0.501N     | 
|COCH-ARM / FISHERS |                                                        |P=0.321N     P=0.515N     P=0.404      P=0.291N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/60 (18%)  14/60 (23%)  7/60 (12%)   4/60 (7%)   |13/60 (22%)  10/59 (17%)  7/60 (12%)   4/60 (7%)    | 
|POLY-3 RATE (b)    |     11/54.55     14/47.68     7/37.42      4/24.34     |13/57.73     10/54.98     7/54.58      4/53.61      | 
|POLY-3 PERCENT (g) |     20.2%        29.4%        18.7%        16.4%       |22.5%        18.2%        12.8%        7.5%         | 
|TERMINAL (d)       |     9/39 (23%)   3/18 (17%)   1/3 (33%)    0/0 (0%)    |11/47 (23%)  9/47 (19%)   4/39 (10%)   2/33 (6%)    | 
|FIRST INCIDENCE    |     537          428          512          404         |401          702          569          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.028 *    P=0.024 *    P=0.048 *   |P=0.049N*    P=0.326N     P=0.210N     P=0.081N     | 
|POLY 3             |     P=0.435N     P=0.196      P=0.537N     P=0.472N    |P=0.012N*    P=0.369N     P=0.136N     P=0.024N*    | 
|POLY 1.5           |     P=0.135N     P=0.250      P=0.391N     P=0.213N    |P=0.010N*    P=0.358N     P=0.126N     P=0.020N*    | 
|POLY 6             |     P=0.226      P=0.134      P=0.467      P=0.386     |P=0.016N*    P=0.378N     P=0.149N     P=0.031N*    | 
|LOGISTIC REGRESSION|     P=0.085N     P=0.293      P=0.490N     P=0.221N    |P=0.010N*    P=0.343N     P=0.103N     P=0.018N*    | 
|COCH-ARM / FISHERS |     P=0.014N*    P=0.327      P=0.222N     P=0.048N*   |P=0.008N**   P=0.338N     P=0.110N     P=0.017N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    2/60 (3%)    3/60 (5%)    4/60 (7%)   |1/60 (2%)    1/59 (2%)    2/60 (3%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     1/53.85      2/44.45      3/35.94      4/23.50     |1/56.86      1/54.87      2/53.74      2/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         4.5%         8.4%         17.0%       |1.8%         1.8%         3.7%         3.8%         | 
|TERMINAL (d)       |     1/39 (3%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    2/39 (5%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      616          483          495         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.299      P=0.038 *    P<0.001 **  |P=0.188      P=0.761      P=0.435      P=0.378      | 
|POLY 3             |     P=0.021 *    P=0.434      P=0.183      P=0.041 *   |P=0.279      P=0.753      P=0.480      P=0.478      | 
|POLY 1.5           |     P=0.040 *    P=0.463      P=0.231      P=0.081     |P=0.291      P=0.754      P=0.489      P=0.489      | 
|POLY 6             |     P=0.013 *    P=0.392      P=0.128      P=0.018 *   |P=0.260      P=0.751      P=0.469      P=0.459      | 
|LOGISTIC REGRESSION|     P=0.034 *    P=0.439      P=0.311      P=0.064     |P=0.188      P=0.761      P=0.435      P=0.378      | 
|COCH-ARM / FISHERS |     P=0.100      P=0.500      P=0.309      P=0.182     |P=0.303      P=0.748      P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Peritoneum: Mesothelium                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/3 (33%)    1/21 (5%)    4/33 (12%)   2/46 (4%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     1/3.00       1/15.80      4/21.29      2/16.95     |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     33.3%        6.3%         18.8%        11.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/3 (33%)    1/6 (17%)    1/2 (50%)    0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      519          414         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.605N     P=0.054      P=0.167     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.566N     P=0.339N     P=0.584N     P=0.450N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.366N     P=0.313N     P=0.512N     P=0.301N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.652      P=0.387N     P=0.716N     P=0.771N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.494N     P=0.605N     P=0.609N     P=0.447N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.196N     P=0.239N     P=0.370N     P=0.176N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/59 (5%)    0/60 (0%)    7/58 (12%)   2/59 (3%)   |6/59 (10%)   5/60 (8%)    4/60 (7%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     3/53.10      0/44.05      7/35.67      2/21.91     |6/55.90      5/56.38      4/53.83      4/53.81      | 
|POLY-3 PERCENT (g) |     5.7%         0.0%         19.6%        9.1%        |10.7%        8.9%         7.4%         7.4%         | 
|TERMINAL (d)       |     3/39 (8%)    0/18 (0%)    1/3 (33%)    0/0 (0%)    |4/46 (9%)    4/47 (9%)    3/39 (8%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          502          562         |722          495          707          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.286N     P<0.001 **   P=0.010 *   |P=0.458N     P=0.492N     P=0.481N     P=0.560N     | 
|POLY 3             |     P=0.064      P=0.157N     P=0.048 *    P=0.487     |P=0.294N     P=0.494N     P=0.395N     P=0.395N     | 
|POLY 1.5           |     P=0.154      P=0.138N     P=0.082      P=0.651     |P=0.279N     P=0.491N     P=0.380N     P=0.378N     | 
|POLY 6             |     P=0.021 *    P=0.189N     P=0.021 *    P=0.304     |P=0.320N     P=0.498N     P=0.414N     P=0.423N     | 
|LOGISTIC REGRESSION|     P=0.068      (e)          P=0.069      P=0.300     |P=0.275N     P=0.486N     P=0.447N     P=0.406N     | 
|COCH-ARM / FISHERS |     P=0.377      P=0.119N     P=0.154      P=0.500N    |P=0.261N     P=0.488N     P=0.361N     P=0.361N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/59 (3%)    6/60 (10%)   3/58 (5%)    4/59 (7%)   |22/59 (37%)  20/60 (33%)  22/60 (37%)  24/60 (40%)  | 
|POLY-3 RATE (b)    |     2/53.10      6/45.99      3/34.37      4/23.65     |22/58.70     20/55.91     22/54.98     24/55.82     | 
|POLY-3 PERCENT (g) |     3.8%         13.1%        8.7%         16.9%       |37.5%        35.8%        40.0%        43.0%        | 
|TERMINAL (d)       |     2/39 (5%)    2/18 (11%)   0/3 (0%)     0/0 (0%)    |14/46 (30%)  18/47 (38%)  17/39 (44%)  15/33 (46%)  | 
|FIRST INCIDENCE    |     729 (T)      499          569          391         |401          695          569          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.035 *    P=0.051      P=0.012 *   |P=0.050      P=0.419N     P=0.350      P=0.120      | 
|POLY 3             |     P=0.075      P=0.093      P=0.315      P=0.092     |P=0.257      P=0.502N     P=0.466      P=0.340      | 
|POLY 1.5           |     P=0.177      P=0.112      P=0.388      P=0.173     |P=0.301      P=0.461N     P=0.520      P=0.390      | 
|POLY 6             |     P=0.021 *    P=0.069      P=0.226      P=0.040 *   |P=0.196      P=0.547N     P=0.402      P=0.270      | 
|LOGISTIC REGRESSION|     P=0.439      P=0.177      P=0.339      P=0.597     |P=0.339      P=0.389N     P=0.523N     P=0.552      | 
|COCH-ARM / FISHERS |     P=0.410      P=0.142      P=0.492      P=0.340     |P=0.357      P=0.398N     P=0.548N     P=0.454      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/59 (2%)    0/60 (0%)    1/58 (2%)    4/59 (7%)   |0/59 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/53.11      0/44.05      1/33.73      4/23.90     |0/55.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         0.0%         3.0%         16.7%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/46 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     727          ---          616          391         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.648N     P=0.446      P=0.026 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.034 *    P=0.537N     P=0.650      P=0.043 *   |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.031 *    P=0.519N     P=0.699      P=0.083     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.058      P=0.563N     P=0.575      P=0.019 *   |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.200      P=0.628N     P=0.716      P=0.773     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    P=0.496N     P=0.748      P=0.182     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/59 (15%)   13/60 (22%)  13/58 (22%)  10/59 (17%) |12/59 (20%)  6/60 (10%)   12/60 (20%)  9/60 (15%)   | 
|POLY-3 RATE (b)    |     9/54.07      13/47.89     13/37.46     10/26.80    |12/56.75     6/55.69      12/55.08     9/54.58      | 
|POLY-3 PERCENT (g) |     16.7%        27.2%        34.7%        37.3%       |21.2%        10.8%        21.8%        16.5%        | 
|TERMINAL (d)       |     5/39 (13%)   4/18 (22%)   0/3 (0%)     0/0 (0%)    |9/46 (20%)   6/47 (13%)   8/39 (21%)   4/33 (12%)   | 
|FIRST INCIDENCE    |     555          428          523          439         |401          729 (T)      569          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.029 *    P<0.001 **   P<0.001 **  |P=0.344      P=0.099N     P=0.430      P=0.585N     | 
|POLY 3             |     P=0.012 *    P=0.146      P=0.042 *    P=0.050     |P=0.470N     P=0.106N     P=0.558      P=0.350N     | 
|POLY 1.5           |     P=0.091      P=0.189      P=0.093      P=0.176     |P=0.447N     P=0.101N     P=0.577      P=0.327N     | 
|POLY 6             |     P<0.001 **   P=0.098      P=0.011 *    P=0.007 **  |P=0.508N     P=0.111N     P=0.538      P=0.391N     | 
|LOGISTIC REGRESSION|     P=0.123      P=0.309      P=0.073      P=0.265     |P=0.414N     P=0.094N     P=0.554N     P=0.266N     | 
|COCH-ARM / FISHERS |     P=0.453      P=0.254      P=0.226      P=0.500     |P=0.424N     P=0.093N     P=0.572N     P=0.301N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    0/60 (0%)    0/58 (0%)    0/59 (0%)   |0/59 (0%)    2/60 (3%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.10      0/44.05      0/33.33      0/20.93     |0/55.86      2/55.69      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         3.6%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/46 (0%)    2/47 (4%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.581N     P=0.243      P=0.467      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.513N     P=0.237      P=0.492      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.500N     P=0.239      P=0.497      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.533N     P=0.235      P=0.486      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.243      P=0.467      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.486N     P=0.252      P=0.504      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    1/60 (2%)    1/58 (2%)    0/59 (0%)   |3/59 (5%)    1/60 (2%)    1/60 (2%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/53.10      1/44.05      1/33.33      0/20.93     |3/56.07      1/55.69      1/53.74      1/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         3.0%         0.0%        |5.4%         1.8%         1.9%         1.9%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    1/3 (33%)    0/0 (0%)    |2/46 (4%)    1/47 (2%)    1/39 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |674          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.025 *    P=0.346      P=0.048 *    (e)         |P=0.276N     P=0.305N     P=0.362N     P=0.413N     | 
|POLY 3             |     P=0.379      P=0.463      P=0.411      (e)         |P=0.200N     P=0.308N     P=0.321N     P=0.324N     | 
|POLY 1.5           |     P=0.498      P=0.481      P=0.448      (e)         |P=0.194N     P=0.305N     P=0.312N     P=0.312N     | 
|POLY 6             |     P=0.241      P=0.437      P=0.362      (e)         |P=0.209N     P=0.313N     P=0.334N     P=0.345N     | 
|LOGISTIC REGRESSION|     (e)          P=0.346      P=0.048 *    (e)         |P=0.217N     P=0.303N     P=0.316N     P=0.323N     | 
|COCH-ARM / FISHERS |     P=0.620N     P=0.504      P=0.496      (e)         |P=0.188N     P=0.303N     P=0.303N     P=0.303N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/60 (12%)   9/59 (15%)   35/58 (60%)  41/56 (73%) |                                                    | 
|POLY-3 RATE (b)    |     7/54.53      9/44.60      35/44.73     41/44.77    |                                                    | 
|POLY-3 PERCENT (g) |     12.8%        20.2%        78.2%        91.6%       |                                                    | 
|TERMINAL (d)       |     2/39 (5%)    1/17 (6%)    2/3 (67%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     663          615          384          391         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.069      P<0.001 **   P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.238      P<0.001 **   P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.298      P<0.001 **   P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.167      P<0.001 **   P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.234      P<0.001 **   P<0.001 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.381      P<0.001 **   P<0.001 **  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    4/59 (7%)    1/58 (2%)    0/56 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/54.18      4/44.16      1/33.09      0/19.41     |                                                    | 
|POLY-3 PERCENT (g) |     1.9%         9.1%         3.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    1/17 (6%)    0/3 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     640          569          714          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.257      P=0.071      P=0.447      P=0.993N    |                                                    | 
|POLY 3             |     P=0.536      P=0.124      P=0.640      P=0.668N    |                                                    | 
|POLY 1.5           |     P=0.425N     P=0.145      P=0.692      P=0.605N    |                                                    | 
|POLY 6             |     P=0.235      P=0.099      P=0.560      P=0.727N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.440N     P=0.221      P=0.688      P=0.723N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.189N     P=0.177      P=0.744      P=0.517N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     40/60 (67%)  43/59 (73%)  36/58 (62%)  27/56 (48%) |                                                    | 
|POLY-3 RATE (b)    |     40/56.29     43/54.04     36/48.32     27/36.46    |                                                    | 
|POLY-3 PERCENT (g) |     71.1%        79.6%        74.5%        74.1%       |                                                    | 
|TERMINAL (d)       |     29/39 (74%)  12/17 (71%)  1/3 (33%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     537          378          384          391         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |                                                    | 
|POLY 3             |     P=0.423      P=0.196      P=0.427      P=0.467     |                                                    | 
|POLY 1.5           |     P=0.214N     P=0.234      P=0.569      P=0.299N    |                                                    | 
|POLY 6             |     P=0.063      P=0.155      P=0.253      P=0.087     |                                                    | 
|LOGISTIC REGRESSION|     P=0.447N     P=0.115      P=0.387      P=0.239     |                                                    | 
|COCH-ARM / FISHERS |     P=0.011N*    P=0.295      P=0.371N     P=0.034N*   |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/60 (40%)  14/59 (24%)  18/60 (30%)  9/60 (15%)  |                                                    | 
|POLY-3 RATE (b)    |     24/57.24     14/47.02     18/42.91     9/26.13     |                                                    | 
|POLY-3 PERCENT (g) |     41.9%        29.8%        41.9%        34.4%       |                                                    | 
|TERMINAL (d)       |     16/39 (41%)  3/18 (17%)   1/3 (33%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     441          569          299          404         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.556      P<0.001 **   P<0.001 **  |                                                    | 
|POLY 3             |     P=0.387N     P=0.138N     P=0.581      P=0.356N    |                                                    | 
|POLY 1.5           |     P=0.092N     P=0.087N     P=0.384N     P=0.062N    |                                                    | 
|POLY 6             |     P=0.253      P=0.228N     P=0.315      P=0.291     |                                                    | 
|LOGISTIC REGRESSION|     P=0.028N*    P=0.040N*    P=0.084N     P=0.166N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.004N**   P=0.044N*    P=0.169N     P=0.002N**  |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Ventral                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/60 (30%)  3/59 (5%)    9/60 (15%)   1/60 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     18/54.46     3/43.99      9/36.50      1/22.10     |                                                    | 
|POLY-3 PERCENT (g) |     33.1%        6.8%         24.7%        4.5%        |                                                    | 
|TERMINAL (d)       |     15/39 (39%)  2/18 (11%)   2/3 (67%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     631          559          512          519         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.031 *    P=0.034N*    P<0.001 **   P=0.412     |                                                    | 
|POLY 3             |     P=0.009N**   P<0.001N**   P=0.269N     P=0.020N*   |                                                    | 
|POLY 1.5           |     P<0.001N**   P<0.001N**   P=0.130N     P<0.001N**  |                                                    | 
|POLY 6             |     P=0.083N     P=0.004N**   P=0.552N     P=0.234N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.293N     P=0.005N**   P=0.402      P=0.451N    |                                                    | 
|COCH-ARM / FISHERS |     P<0.001N**   P<0.001N**   P=0.040N*    P<0.001N**  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    18/59 (31%)  43/60 (72%) |2/60 (3%)    3/60 (5%)    9/60 (15%)   48/60 (80%)  | 
|POLY-3 RATE (b)    |     0/53.85      2/45.52      18/39.87     43/49.52    |2/57.25      3/56.31      9/54.39      48/56.66     | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         45.2%        86.8%       |3.5%         5.3%         16.6%        84.7%        | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    1/3 (33%)    0/0 (0%)    |1/47 (2%)    1/47 (2%)    6/39 (15%)   30/33 (91%)  | 
|FIRST INCIDENCE    |     ---          378          483          359         |620          582          636          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.234      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.489      P=0.017 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.202      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.493      P=0.021 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.218      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.496      P=0.024 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.181      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.489      P=0.019 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.560      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.519      P=0.028 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.248      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.027 *    P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/60 (10%)   6/60 (10%)   9/60 (15%)   7/60 (12%)  |1/60 (2%)    0/59 (0%)    1/60 (2%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     6/54.06      6/44.47      9/37.78      7/25.26     |1/56.86      0/54.87      1/53.74      0/52.53      | 
|POLY-3 PERCENT (g) |     11.1%        13.5%        23.8%        27.7%       |1.8%         0.0%         1.9%         0.0%         | 
|TERMINAL (d)       |     5/39 (13%)   3/18 (17%)   1/3 (33%)    0/0 (0%)    |1/47 (2%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     674          615          483          419         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.170      P<0.001 **   P<0.001 **  |P=0.456N     P=0.500N     P=0.720      P=0.571N     | 
|POLY 3             |     P=0.027 *    P=0.480      P=0.094      P=0.084     |P=0.393N     P=0.507N     P=0.748      P=0.516N     | 
|POLY 1.5           |     P=0.099      P=0.543      P=0.161      P=0.219     |P=0.389N     P=0.506N     P=0.753      P=0.510N     | 
|POLY 6             |     P=0.004 **   P=0.388      P=0.039 *    P=0.020 *   |P=0.401N     P=0.509N     P=0.741      P=0.526N     | 
|LOGISTIC REGRESSION|     P=0.011 *    P=0.310      P=0.109      P=0.091     |P=0.456N     (e)          P=0.720      (e)          | 
|COCH-ARM / FISHERS |     P=0.342      P=0.619N     P=0.291      P=0.500     |P=0.384N     P=0.504N     P=0.752N     P=0.504N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/60 (12%)   33/60 (55%)  38/60 (63%)  47/60 (78%) |22/60 (37%)  38/59 (64%)  48/60 (80%)  48/59 (81%)  | 
|POLY-3 RATE (b)    |     7/54.65      33/55.13     38/50.69     47/51.81    |22/57.71     38/57.66     48/57.83     48/57.03     | 
|POLY-3 PERCENT (g) |     12.8%        59.9%        75.0%        90.7%       |38.1%        65.9%        83.0%        84.2%        | 
|TERMINAL (d)       |     2/39 (5%)    7/18 (39%)   2/3 (67%)    0/0 (0%)    |20/47 (43%)  32/47 (68%)  34/39 (87%)  27/33 (82%)  | 
|FIRST INCIDENCE    |     537          378          384          391         |401          495          370          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      2/45.20      0/34.77      0/21.46     |0/56.86      0/54.87      0/53.74      0/52.53      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          428          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.578N     P=0.199      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.622      P=0.201      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.563N     P=0.217      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.429      P=0.179      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.142N     P=0.447      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.382N     P=0.248      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |2/60 (3%)    0/59 (0%)    0/60 (0%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      0/21.46     |2/57.00      0/54.87      0/53.74      0/52.53      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |3.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |706          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.090N     P=0.258N     P=0.281N     P=0.315N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.067N     P=0.246N     P=0.251N     P=0.256N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.067N     P=0.244N     P=0.245N     P=0.249N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.067N     P=0.248N     P=0.259N     P=0.269N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.070N     P=0.243N     P=0.244N     P=0.249N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.068N     P=0.252N     P=0.248N     P=0.252N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/60 (15%)   8/60 (13%)   13/60 (22%)  16/60 (27%) |36/60 (60%)  44/59 (75%)  43/60 (72%)  46/59 (78%)  | 
|POLY-3 RATE (b)    |     9/55.67      8/45.57      13/40.79     16/31.89    |36/56.99     44/57.32     43/55.99     46/57.01     | 
|POLY-3 PERCENT (g) |     16.2%        17.6%        31.9%        50.2%       |63.2%        76.8%        76.8%        80.7%        | 
|TERMINAL (d)       |     4/39 (10%)   4/18 (22%)   1/3 (33%)    0/0 (0%)    |34/47 (72%)  36/47 (77%)  32/39 (82%)  26/33 (79%)  | 
|FIRST INCIDENCE    |     441          378          298          359         |707          495          525          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.240      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.087      P=0.007 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.532      P=0.058      P<0.001 **  |P=0.023 *    P=0.079      P=0.077      P=0.026 *    | 
|POLY 1.5           |     P=0.003 **   P=0.598N     P=0.117      P=0.009 **  |P=0.026 *    P=0.072      P=0.093      P=0.026 *    | 
|POLY 6             |     P<0.001 **   P=0.419      P=0.017 *    P<0.001 **  |P=0.020 *    P=0.093      P=0.063      P=0.026 *    | 
|LOGISTIC REGRESSION|     P=0.295      P=0.428N     P=0.574N     P=0.581N    |P=0.011 *    P=0.046 *    P=0.033 *    P=0.010 *    | 
|COCH-ARM / FISHERS |     P=0.033 *    P=0.500N     P=0.240      P=0.088     |P=0.032 *    P=0.067      P=0.124      P=0.027 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/59 (7%)    2/60 (3%)    0/60 (0%)    1/60 (2%)   |0/59 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     4/54.87      2/44.75      0/34.77      1/21.93     |0/56.07      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     7.3%         4.5%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     533          499          ---          589         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.333N     P=0.457N     P=0.146N     P=0.673     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.149N     P=0.435N     P=0.146N     P=0.524N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.091N     P=0.388N     P=0.100N     P=0.352N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.261N     P=0.506N     P=0.234N     P=0.584     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.005N**   P=0.101N     P=0.004N**   P=0.012N*   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.049N*    P=0.332N     P=0.057N     P=0.177N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/59 (3%)    2/60 (3%)    1/60 (2%)    1/60 (2%)   |1/59 (2%)    1/59 (2%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     2/53.49      2/44.75      1/34.97      1/22.27     |1/56.07      1/55.10      0/53.74      1/53.67      | 
|POLY-3 PERCENT (g) |     3.7%         4.5%         2.9%         4.5%        |1.8%         1.8%         0.0%         1.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     640          499          676          421         |729 (T)      669          ---          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.291      P=0.539      P=0.658      P=0.520     |P=0.578N     P=0.758      P=0.537N     P=0.717      | 
|POLY 3             |     P=0.601N     P=0.628      P=0.640N     P=0.660     |P=0.535N     P=0.757      P=0.508N     P=0.751      | 
|POLY 1.5           |     P=0.455N     P=0.661      P=0.578N     P=0.646N    |P=0.530N     P=0.758      P=0.503N     P=0.757      | 
|POLY 6             |     P=0.491      P=0.576      P=0.700      P=0.496     |P=0.541N     P=0.755      P=0.515N     P=0.739      | 
|LOGISTIC REGRESSION|     P=0.194N     P=0.574N     P=0.536N     P=0.243N    |P=0.507N     P=0.759N     (e)          P=0.745N     | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.684N     P=0.494N     P=0.494N    |P=0.524N     P=0.752N     P=0.496N     P=0.748N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/59 (10%)   2/60 (3%)    1/60 (2%)    2/60 (3%)   |5/59 (8%)    3/59 (5%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     6/55.74      2/44.75      1/35.20      2/23.11     |5/56.61      3/55.89      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     10.8%        4.5%         2.8%         8.7%        |8.8%         5.4%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |3/47 (6%)    1/47 (2%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     533          499          603          391         |620          429          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.416N     P=0.237N     P=0.193N     P=0.652     |P=0.017N*    P=0.368N     P=0.148N     P=0.064N     | 
|POLY 3             |     P=0.181N     P=0.218N     P=0.176N     P=0.543N    |P=0.009N**   P=0.365N     P=0.115N     P=0.037N*    | 
|POLY 1.5           |     P=0.109N     P=0.175N     P=0.110N     P=0.330N    |P=0.008N**   P=0.361N     P=0.108N     P=0.034N*    | 
|POLY 6             |     P=0.300N     P=0.290N     P=0.302N     P=0.461     |P=0.011N*    P=0.370N     P=0.126N     P=0.044N*    | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.015N*    P=0.003N**   P<0.001N**  |P=0.006N**   P=0.326N     P=0.099N     P=0.030N*    | 
|COCH-ARM / FISHERS |     P=0.055N     P=0.131N     P=0.054N     P=0.131N    |P=0.008N**   P=0.358N     P=0.100N     P=0.027N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/59 (7%)    2/60 (3%)    7/60 (12%)   7/60 (12%)  |1/60 (2%)    1/59 (2%)    1/60 (2%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     4/52.89      2/45.66      7/37.75      7/25.69     |1/56.90      1/55.05      1/54.08      3/53.72      | 
|POLY-3 PERCENT (g) |     7.6%         4.4%         18.5%        27.3%       |1.8%         1.8%         1.9%         5.6%         | 
|TERMINAL (d)       |     3/38 (8%)    0/18 (0%)    1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     720          378          502          463         |719          684          636          665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.571N     P=0.002 **   P<0.001 **  |P=0.126      P=0.747      P=0.724      P=0.216      | 
|POLY 3             |     P=0.010 *    P=0.407N     P=0.109      P=0.034 *   |P=0.163      P=0.753      P=0.749      P=0.286      | 
|POLY 1.5           |     P=0.026 *    P=0.371N     P=0.168      P=0.097     |P=0.169      P=0.754      P=0.754      P=0.296      | 
|POLY 6             |     P=0.003 **   P=0.465N     P=0.054      P=0.008 **  |P=0.153      P=0.752      P=0.743      P=0.269      | 
|LOGISTIC REGRESSION|     P=0.255      P=0.179N     P=0.246      P=0.173     |P=0.185      P=0.761      P=0.746N     P=0.309      | 
|COCH-ARM / FISHERS |     P=0.094      P=0.332N     P=0.274      P=0.274     |P=0.175      P=0.748      P=0.752N     P=0.309      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/59 (2%)    2/60 (3%)    0/60 (0%)    3/60 (5%)   |2/60 (3%)    0/59 (0%)    1/60 (2%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     1/53.15      2/45.20      0/34.77      3/23.41     |2/56.86      0/54.87      1/53.86      1/53.57      | 
|POLY-3 PERCENT (g) |     1.9%         4.4%         0.0%         12.8%       |3.5%         0.0%         1.9%         1.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     649          428          ---          421         |729 (T)      ---          698          665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.050      P=0.404      P=0.677N     P=0.030 *   |P=0.514N     P=0.239N     P=0.554N     P=0.596N     | 
|POLY 3             |     P=0.183      P=0.444      P=0.581N     P=0.109     |P=0.440N     P=0.246N     P=0.519N     P=0.521N     | 
|POLY 1.5           |     P=0.208      P=0.472      P=0.545N     P=0.179     |P=0.436N     P=0.244N     P=0.511N     P=0.511N     | 
|POLY 6             |     P=0.184      P=0.403      P=0.630N     P=0.059     |P=0.447N     P=0.247N     P=0.529N     P=0.538N     | 
|LOGISTIC REGRESSION|     P=0.542N     P=0.742      P=0.510N     P=0.697     |P=0.434N     (e)          P=0.524N     P=0.506N     | 
|COCH-ARM / FISHERS |     P=0.281      P=0.506      P=0.496N     P=0.316     |P=0.431N     P=0.252N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)   |                                                    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      2/22.78     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         8.8%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          404         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    (e)          (e)          P=0.081     |                                                    | 
|POLY 3             |     P=0.085      (e)          (e)          P=0.112     |                                                    | 
|POLY 1.5           |     P=0.057      (e)          (e)          P=0.156     |                                                    | 
|POLY 6             |     P=0.197      (e)          (e)          P=0.079     |                                                    | 
|LOGISTIC REGRESSION|     P=0.148      (e)          (e)          P=0.676     |                                                    | 
|COCH-ARM / FISHERS |     P=0.053      (e)          (e)          P=0.248     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 51      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/60 (22%)  21/60 (35%)  12/60 (20%)  19/60 (32%) |                                                    | 
|POLY-3 RATE (b)    |     13/56.48     21/50.73     12/38.79     19/33.26    |                                                    | 
|POLY-3 PERCENT (g) |     23.0%        41.4%        30.9%        57.1%       |                                                    | 
|TERMINAL (d)       |     5/39 (13%)   5/18 (28%)   1/3 (33%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     441          471          502          391         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P=0.006 **   P<0.001 **  |                                                    | 
|POLY 3             |     P=0.003 **   P=0.031 *    P=0.270      P<0.001 **  |                                                    | 
|POLY 1.5           |     P=0.037 *    P=0.046 *    P=0.434      P=0.015 *   |                                                    | 
|POLY 6             |     P<0.001 **   P=0.017 *    P=0.114      P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P=0.346      P=0.221      P=0.570N     P=0.523     |                                                    | 
|COCH-ARM / FISHERS |     P=0.293      P=0.078      P=0.500N     P=0.151     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/60 (17%)  14/60 (23%)  13/60 (22%)  31/60 (52%) |                                                    | 
|POLY-3 RATE (b)    |     10/57.13     14/49.66     13/42.49     31/42.05    |                                                    | 
|POLY-3 PERCENT (g) |     17.5%        28.2%        30.6%        73.7%       |                                                    | 
|TERMINAL (d)       |     2/39 (5%)    2/18 (11%)   0/3 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     533          428          384          391         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.071      P=0.032 *    P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.138      P=0.099      P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.181      P=0.174      P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.090      P=0.038 *    P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P=0.292      P=0.490N     P=0.172N     P=0.578     |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.247      P=0.322      P<0.001 **  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 52      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/56 (0%)    0/54 (0%)    0/55 (0%)    0/55 (0%)   |1/57 (2%)    0/55 (0%)    2/58 (3%)    2/58 (3%)    | 
|POLY-3 RATE (b)    |     0/50.79      0/39.13      0/31.66      0/19.60     |1/54.00      0/52.04      2/51.74      2/51.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |1.9%         0.0%         3.9%         3.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/16 (0%)    0/3 (0%)     0/0 (0%)    |0/45 (0%)    0/44 (0%)    2/37 (5%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |706          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.136      P=0.516N     P=0.443      P=0.385      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.206      P=0.507N     P=0.485      P=0.482      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.216      P=0.507N     P=0.494      P=0.494      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.191      P=0.508N     P=0.473      P=0.462      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.164      P=0.508N     P=0.473      P=0.446      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.226      P=0.509N     P=0.507      P=0.507      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    1/60 (2%)    2/60 (3%)    3/60 (5%)   |1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/52.85      1/44.23      2/35.43      3/23.44     |1/56.86      1/55.69      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         5.6%         12.8%       |1.8%         1.8%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          684          581          471         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.397      P=0.091      P=0.037 *   |P=0.387N     P=0.761      P=0.720      P=0.571N     | 
|POLY 3             |     P=0.016 *    P=0.465      P=0.163      P=0.039 *   |P=0.320N     P=0.756      P=0.748      P=0.513N     | 
|POLY 1.5           |     P=0.024 *    P=0.482      P=0.193      P=0.064     |P=0.313N     P=0.758      P=0.753      P=0.507N     | 
|POLY 6             |     P=0.015 *    P=0.440      P=0.128      P=0.023 *   |P=0.333N     P=0.754      P=0.741      P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.066      P=0.482      P=0.230      P=0.422     |P=0.387N     P=0.761      P=0.720      (e)          | 
|COCH-ARM / FISHERS |     P=0.052      P=0.504      P=0.252      P=0.125     |P=0.304N     P=0.752N     P=0.752N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 53      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/59 (17%)  11/60 (18%)  9/60 (15%)   7/60 (12%)  |22/60 (37%)  24/60 (40%)  22/60 (37%)  9/60 (15%)   | 
|POLY-3 RATE (b)    |     10/53.36     11/47.38     9/37.48      7/26.22     |22/58.02     24/56.54     22/54.03     9/54.03      | 
|POLY-3 PERCENT (g) |     18.7%        23.2%        24.0%        26.7%       |37.9%        42.5%        40.7%        16.7%        | 
|TERMINAL (d)       |     8/38 (21%)   3/18 (17%)   1/3 (33%)    0/0 (0%)    |17/47 (36%)  21/47 (45%)  19/39 (49%)  6/33 (18%)   | 
|FIRST INCIDENCE    |     649          499          384          404         |620          505          698          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.101      P<0.001 **   P<0.001 **  |P=0.104N     P=0.417      P=0.297      P=0.068N     | 
|POLY 3             |     P=0.234      P=0.380      P=0.367      P=0.318     |P=0.010N*    P=0.381      P=0.456      P=0.009N**   | 
|POLY 1.5           |     P=0.516      P=0.440      P=0.517      P=0.589     |P=0.007N**   P=0.401      P=0.508      P=0.007N**   | 
|POLY 6             |     P=0.047 *    P=0.298      P=0.189      P=0.094     |P=0.020N*    P=0.352      P=0.387      P=0.015N*    | 
|LOGISTIC REGRESSION|     P=0.464N     P=0.495      P=0.332      P=0.565N    |P=0.012N*    P=0.403      P=0.449      P=0.008N**   | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.517      P=0.484N     P=0.288N    |P=0.005N**   P=0.426      P=0.575N     P=0.006N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/59 (5%)    2/60 (3%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    2/60 (3%)    1/60 (2%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     3/52.85      2/44.05      0/34.77      0/21.46     |0/56.86      2/55.79      1/53.74      1/53.33      | 
|POLY-3 PERCENT (g) |     5.7%         4.5%         0.0%         0.0%        |0.0%         3.6%         1.9%         1.9%         | 
|TERMINAL (d)       |     3/38 (8%)    2/18 (11%)   0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    1/39 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          705          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.673N     P=0.542      P=0.738N     P=1.000N    |P=0.334      P=0.233      P=0.463      P=0.429      | 
|POLY 3             |     P=0.100N     P=0.582N     P=0.213N     P=0.346N    |P=0.402      P=0.233      P=0.489      P=0.487      | 
|POLY 1.5           |     P=0.051N     P=0.542N     P=0.165N     P=0.223N    |P=0.417      P=0.235      P=0.493      P=0.493      | 
|POLY 6             |     P=0.237N     P=0.638N     P=0.297N     P=0.516N    |P=0.378      P=0.232      P=0.482      P=0.477      | 
|LOGISTIC REGRESSION|     P=0.673N     P=0.542      (e)          (e)         |P=0.378      P=0.234      P=0.463      P=0.429      | 
|COCH-ARM / FISHERS |     P=0.024N*    P=0.492N     P=0.119N     P=0.119N    |P=0.433      P=0.248      P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 54      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)  |2/2 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/0.00       1/1.00      |2/2.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         100.0%      |100.0%       0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          544         |706          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    1/60 (2%)    2/59 (3%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      1/35.30      2/21.50     |0/56.86      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.8%         9.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          564          581         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.446      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.049 *    (e)          P=0.419      P=0.107     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          P=0.454      P=0.150     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.089      (e)          P=0.372      P=0.075     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.030 *    (e)          P=0.660      P=0.051     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.060      (e)          P=0.500      P=0.244     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 55      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    2/60 (3%)    0/59 (0%)   |0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      2/35.22      0/20.74     |0/56.86      0/54.87      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          597          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030 *    (e)          P=0.030 *    (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.174      (e)          P=0.159      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.263      (e)          P=0.190      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.105      (e)          P=0.124      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.165      (e)          P=0.154      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.425      (e)          P=0.248      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    2/60 (3%)    3/59 (5%)   |0/60 (0%)    0/59 (0%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      2/44.07      2/35.16      3/22.48     |0/56.86      0/54.87      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         5.7%         13.4%       |0.0%         0.0%         1.9%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          726          616          439         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.103      P=0.024 *    P=0.010 *   |P=0.496      (e)          P=0.463      (e)          | 
|POLY 3             |     P=0.020 *    P=0.196      P=0.159      P=0.035 *   |P=0.528      (e)          P=0.489      (e)          | 
|POLY 1.5           |     P=0.036 *    P=0.214      P=0.189      P=0.059     |P=0.540      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.014 *    P=0.172      P=0.124      P=0.021 *   |P=0.506      (e)          P=0.482      (e)          | 
|LOGISTIC REGRESSION|     P=0.014 *    P=0.109      P=0.130      P=0.278     |(e)          (e)          P=0.463      (e)          | 
|COCH-ARM / FISHERS |     P=0.087      P=0.248      P=0.248      P=0.119     |P=0.551      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 56      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |7/60 (12%)   6/59 (10%)   1/60 (2%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |                                                        |7/56.86      6/54.87      1/53.74      3/53.57      | 
|POLY-3 PERCENT (g) |                                                        |12.3%        10.9%        1.9%         5.6%         | 
|TERMINAL (d)       |                                                        |7/47 (15%)   6/47 (13%)   1/39 (3%)    2/33 (6%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.113N     P=0.500N     P=0.057N     P=0.324N     | 
|POLY 3             |                                                        |P=0.049N*    P=0.527N     P=0.038N*    P=0.185N     | 
|POLY 1.5           |                                                        |P=0.045N*    P=0.521N     P=0.035N*    P=0.173N     | 
|POLY 6             |                                                        |P=0.055N     P=0.533N     P=0.042N*    P=0.207N     | 
|LOGISTIC REGRESSION|                                                        |P=0.081N     P=0.500N     P=0.057N     P=0.237N     | 
|COCH-ARM / FISHERS |                                                        |P=0.041N*    P=0.513N     P=0.031N*    P=0.161N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |8/60 (13%)   6/59 (10%)   9/60 (15%)   8/60 (13%)   | 
|POLY-3 RATE (b)    |                                                        |8/57.01      6/54.92      9/54.22      8/53.81      | 
|POLY-3 PERCENT (g) |                                                        |14.0%        10.9%        16.6%        14.9%        | 
|TERMINAL (d)       |                                                        |7/47 (15%)   5/47 (11%)   6/39 (15%)   7/33 (21%)   | 
|FIRST INCIDENCE    |                                                        |691          716          656          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.182      P=0.395N     P=0.357      P=0.334      | 
|POLY 3             |                                                        |P=0.391      P=0.417N     P=0.455      P=0.558      | 
|POLY 1.5           |                                                        |P=0.417      P=0.410N     P=0.474      P=0.581      | 
|POLY 6             |                                                        |P=0.347      P=0.424N     P=0.432      P=0.515      | 
|LOGISTIC REGRESSION|                                                        |P=0.349      P=0.422N     P=0.435      P=0.523      | 
|COCH-ARM / FISHERS |                                                        |P=0.443      P=0.402N     P=0.500      P=0.605N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 57      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
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|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
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|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
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|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/60 (3%)    1/59 (2%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/57.70      1/54.87      1/54.61      0/53.33      | 
|POLY-3 PERCENT (g) |                                                        |3.5%         1.8%         1.8%         0.0%         | 
|TERMINAL (d)       |                                                        |1/47 (2%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |                                                        |401          729 (T)      370          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.165N     P=0.500N     P=0.523N     P=0.278N     | 
|POLY 3             |                                                        |P=0.145N     P=0.517N     P=0.519N     P=0.256N     | 
|POLY 1.5           |                                                        |P=0.140N     P=0.513N     P=0.511N     P=0.247N     | 
|POLY 6             |                                                        |P=0.153N     P=0.521N     P=0.530N     P=0.269N     | 
|LOGISTIC REGRESSION|                                                        |P=0.102N     P=0.484N     P=0.340N     P=0.235N     | 
|COCH-ARM / FISHERS |                                                        |P=0.134N     P=0.506N     P=0.500N     P=0.248N     | 
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(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).