Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/12590

TDMS Study 05203-09 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:12:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           MICE, FINAL#1                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:12:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  O-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Cytoplasmic Alteration Focal                                                                 
Heart                                  Infiltration Cellular Mixed Cell                                                             
                                       Inflammation Chronic Focal                                                                   
                                       Mineralization                                                                               
Kidney                                 Congestion                                                                                   
                                       Cyst                                                                                         
                                       Inflammation                                                                                 
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Accumulation, Hyaline Droplet                                                                
                                       Dilatation                                                                                   
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Infiltration Cellular Mixed Cell                                                             
                                       Necrosis                                                                                     
Liver: Hepatocyte                      Fatty Change Diffuse                                                                         
                                       Syncytial Alteration Focal                                                                   
                                       Vacuolization Cytoplasmic Diffuse                                                            
                                       Vacuolization Cytoplasmic Focal                                                              
Liver: Hepatocyte, Centrilobular       Depletion Glycogen                                                                           
                                       Fatty Change                                                                                 
Liver: Oval Cell                       Hyperplasia                                                                                  
Lung                                   Congestion                                                                                   
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Infiltration Cellular Mixed Cell                                                             
Lymph Node, Mediastinal                Hemorrhage                                                                                   
Mesentery                              Inflammation Chronic                                                                         
Mesentery: Artery                      Inflammation Chronic                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Preputial Gland                        Degeneration Cystic                                                                          
                                       Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Skeletal Muscle                        Hemorrhage Focal                                                                             
Skin: Subcutaneous Tissue              Edema                                                                                        
                                       Hemorrhage Focal                                                                             
                                       Inflammation Chronic Focal                                                                   
Spleen                                 Depletion Cellular                                                                           
                                       Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Inflammation Focal                                                                           
                                       Ulcer                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Erosion                                                                                      
                                       Inflammation Focal                                                                           
Thymus                                 Atrophy                                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:12:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
                                       Cyst                                                                                         
Thyroid Gland                          Degeneration Cystic Focal                                                                    
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone                                   Hyperostosis                                                                                 
Clitoral Gland                         Degeneration Cystic                                                                          
                                       Inflammation Chronic                                                                         
Heart                                  Inflammation Chronic Focal                                                                   
Kidney                                 Hyperplasia Lymphoid                                                                         
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Accumulation, Hyaline Droplet                                                                
                                       Casts Protein                                                                                
                                       Pigmentation                                                                                 
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
Liver: Hepatocyte                      Necrosis Focal                                                                               
                                       Vacuolization Cytoplasmic Focal                                                              
Liver: Oval Cell                       Hyperplasia                                                                                  
Lung                                   Infiltration Cellular Mixed Cell                                                             
Lymph Node, Mediastinal                Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Lymph Node, Mesenteric                 Hyperplasia                                                                                  
Lymph Node: Renal                      Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Nose: Mucosa, Glands                   Dilatation Focal                                                                             
Ovary                                  Cyst                                                                                         
Skin: Subcutaneous Tissue              Edema                                                                                        
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia Lymphoid                                                                         
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Inflammation Focal                                                                           
Thymus                                 Hyperplasia Lymphoid                                                                         
Thyroid Gland                          Degeneration Cystic Focal                                                                    
Thyroid Gland: Follicle                Cyst                                                                                         
Uterus                                 Hydrometra                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   O-NITROTOLUENE      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    0/58 (0%)    0/60 (0%)   |2/59 (3%)    0/59 (0%)    1/58 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/49.97      0/22.81      0/9.13      |2/56.26      0/53.27      1/55.51      0/39.77      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         0.0%         0.0%        |3.6%         0.0%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          641          ---          ---         |299          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.814      P=0.460      (e)          (e)         |P=0.331N     P=0.255N     P=0.523N     P=0.439N     | 
|POLY 3             |     P=0.603      P=0.474      (e)          (e)         |P=0.207N     P=0.250N     P=0.505N     P=0.322N     | 
|POLY 1.5           |     P=0.702      P=0.485      (e)          (e)         |P=0.199N     P=0.246N     P=0.504N     P=0.279N     | 
|POLY 6             |     P=0.485      P=0.460      (e)          (e)         |P=0.238N     P=0.254N     P=0.509N     P=0.396N     | 
|LOGISTIC REGRESSION|     P=0.911N     P=0.537      (e)          (e)         |P=0.144N     P=0.170N     P=0.734N     P=0.142N     | 
|COCH-ARM / FISHERS |     P=0.568N     P=0.500      (e)          (e)         |P=0.187N     P=0.248N     P=0.506N     P=0.244N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    0/59 (0%)    2/58 (3%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      2/49.65      0/22.81      0/9.13      |0/55.32      0/53.27      2/55.51      0/39.77      | 
|POLY-3 PERCENT (g) |     0.0%         4.0%         0.0%         0.0%        |0.0%         0.0%         3.6%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    2/34 (6%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.380      P=0.151      (e)          (e)         |P=0.265      (e)          P=0.217      (e)          | 
|POLY 3             |     P=0.392      P=0.208      (e)          (e)         |P=0.383      (e)          P=0.238      (e)          | 
|POLY 1.5           |     P=0.631      P=0.221      (e)          (e)         |P=0.489      (e)          P=0.238      (e)          | 
|POLY 6             |     P=0.166      P=0.194      (e)          (e)         |P=0.255      (e)          P=0.236      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.151      (e)          (e)         |(e)          (e)          P=0.217      (e)          | 
|COCH-ARM / FISHERS |     P=0.406N     P=0.248      (e)          (e)         |P=0.598      (e)          P=0.244      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/60 (12%)   2/60 (3%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    1/59 (2%)    0/58 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     7/56.99      2/49.65      0/22.81      0/9.13      |0/55.32      1/53.27      0/55.51      0/39.77      | 
|POLY-3 PERCENT (g) |     12.3%        4.0%         0.0%         0.0%        |0.0%         1.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     7/52 (14%)   2/34 (6%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.345N     P=0.224N     P=1.000N     P=1.000N    |P=0.830N     P=0.476      (e)          (e)          | 
|POLY 3             |     P=0.019N*    P=0.119N     P=0.133N     P=0.381N    |P=0.562N     P=0.492      (e)          (e)          | 
|POLY 1.5           |     P=0.006N**   P=0.101N     P=0.046N*    P=0.136N    |P=0.568N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.052N     P=0.145N     P=0.348N     P=0.573N    |P=0.595N     P=0.489      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.345N     P=0.224N     (e)          (e)         |(e)          P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.002N**   P=0.081N     P=0.007N**   P=0.006N**  |P=0.565N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/56 (0%)    0/60 (0%)   |2/59 (3%)    0/57 (0%)    0/58 (0%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/22.24      0/9.13      |2/55.32      0/51.53      0/55.51      0/38.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |3.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    0/45 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.206N     P=0.271N     P=0.261N     P=0.793N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.091N     P=0.254N     P=0.237N     P=0.323N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.104N     P=0.251N     P=0.237N     P=0.280N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.083N     P=0.257N     P=0.240N     P=0.397N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.206N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.257N     P=0.252N     P=0.248N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/57.18      2/40.62      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.024 *    (e)          (e)          P=0.163      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.038 *    (e)          (e)          P=0.174      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.202      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.138      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.079      (e)          (e)          P=0.316      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    1/60 (2%)    0/60 (0%)   |0/60 (0%)    0/58 (0%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      2/50.17      1/24.00      0/9.13      |0/56.31      0/53.22      1/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |     0.0%         4.0%         4.2%         0.0%        |0.0%         0.0%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          572          569          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.098      P=0.179      P=0.217      (e)         |P=0.527      (e)          P=0.480      (e)          | 
|POLY 3             |     P=0.199      P=0.211      P=0.352      (e)         |P=0.518      (e)          P=0.503      (e)          | 
|POLY 1.5           |     P=0.429      P=0.222      P=0.414      (e)         |P=0.609      (e)          P=0.503      (e)          | 
|POLY 6             |     P=0.101      P=0.197      P=0.288      (e)         |P=0.413      (e)          P=0.500      (e)          | 
|LOGISTIC REGRESSION|     P=0.800      P=0.273      P=0.656      (e)         |(e)          (e)          P=0.480      (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.248      P=0.500      (e)         |P=0.695      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    3/60 (5%)    2/60 (3%)    0/60 (0%)   |1/60 (2%)    0/58 (0%)    2/60 (3%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      3/50.40      2/25.02      0/9.13      |1/56.85      0/53.22      2/57.82      2/40.51      | 
|POLY-3 PERCENT (g) |     0.0%         6.0%         8.0%         0.0%        |1.8%         0.0%         3.5%         4.9%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          542          410          ---         |562          ---          553          583          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.081      P=0.211      (e)         |P=0.128      P=0.507N     P=0.497      P=0.379      | 
|POLY 3             |     P=0.075      P=0.099      P=0.115      (e)         |P=0.162      P=0.513N     P=0.506      P=0.386      | 
|POLY 1.5           |     P=0.301      P=0.108      P=0.159      (e)         |P=0.199      P=0.510N     P=0.506      P=0.439      | 
|POLY 6             |     P=0.022 *    P=0.090      P=0.081      (e)         |P=0.132      P=0.517N     P=0.501      P=0.309      | 
|LOGISTIC REGRESSION|     P=0.279N     P=0.148      P=0.586      (e)         |P=0.387      P=0.498N     P=0.321      P=0.632      | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.122      P=0.248      (e)         |P=0.250      P=0.508N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    2/58 (3%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      2/53.22      0/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         3.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.735N     P=0.212      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.443N     P=0.225      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.427N     P=0.228      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.498N     P=0.222      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.212      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.403N     P=0.239      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |11/58 (19%)  4/57 (7%)    5/57 (9%)    2/58 (3%)    | 
|POLY-3 RATE (b)    |                                                        |11/54.31     4/51.20      5/54.26      2/38.56      | 
|POLY-3 PERCENT (g) |                                                        |20.3%        7.8%         9.2%         5.2%         | 
|TERMINAL (d)       |                                                        |11/50 (22%)  4/44 (9%)    5/45 (11%)   0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.425N     P=0.078N     P=0.128N     P=0.461      | 
|POLY 3             |                                                        |P=0.024N*    P=0.059N     P=0.087N     P=0.041N*    | 
|POLY 1.5           |                                                        |P=0.015N*    P=0.056N     P=0.087N     P=0.019N*    | 
|POLY 6             |                                                        |P=0.041N*    P=0.064N     P=0.092N     P=0.113N     | 
|LOGISTIC REGRESSION|                                                        |P=0.199N     P=0.078N     P=0.128N     P=0.437N     | 
|COCH-ARM / FISHERS |                                                        |P=0.009N**   P=0.051N     P=0.095N     P=0.008N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/58 (5%)    2/57 (4%)    0/57 (0%)    0/58 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/54.31      2/51.20      0/54.26      0/38.28      | 
|POLY-3 PERCENT (g) |                                                        |5.5%         3.9%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |3/50 (6%)    2/44 (5%)    0/45 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.140N     P=0.558N     P=0.141N     P=0.679N     | 
|POLY 3             |                                                        |P=0.044N*    P=0.527N     P=0.120N     P=0.195N     | 
|POLY 1.5           |                                                        |P=0.042N*    P=0.520N     P=0.120N     P=0.155N     | 
|POLY 6             |                                                        |P=0.049N*    P=0.535N     P=0.122N     P=0.272N     | 
|LOGISTIC REGRESSION|                                                        |P=0.140N     P=0.558N     (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.040N*    P=0.508N     P=0.125N     P=0.122N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/58 (5%)    2/57 (4%)    0/57 (0%)    1/58 (2%)    | 
|POLY-3 RATE (b)    |                                                        |3/54.31      2/51.20      0/54.26      1/38.39      | 
|POLY-3 PERCENT (g) |                                                        |5.5%         3.9%         0.0%         2.6%         | 
|TERMINAL (d)       |                                                        |3/50 (6%)    2/44 (5%)    0/45 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.583N     P=0.558N     P=0.141N     P=0.452      | 
|POLY 3             |                                                        |P=0.174N     P=0.527N     P=0.120N     P=0.438N     | 
|POLY 1.5           |                                                        |P=0.173N     P=0.520N     P=0.120N     P=0.373N     | 
|POLY 6             |                                                        |P=0.176N     P=0.535N     P=0.122N     P=0.542N     | 
|LOGISTIC REGRESSION|                                                        |P=0.413N     P=0.558N     (e)          P=0.715      | 
|COCH-ARM / FISHERS |                                                        |P=0.164N     P=0.508N     P=0.125N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    3/60 (5%)    1/60 (2%)   |0/60 (0%)    1/60 (2%)    1/59 (2%)    0/58 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/49.65      3/25.42      1/9.97      |0/56.31      1/54.01      1/56.26      0/38.16      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         11.8%        10.0%       |0.0%         1.9%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      492          391         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.415      P=0.060      P=0.396     |P=0.539      P=0.476      P=0.480      (e)          | 
|POLY 3             |     P=0.031 *    P=0.473      P=0.039 *    P=0.280     |P=0.600      P=0.492      P=0.500      (e)          | 
|POLY 1.5           |     P=0.069      P=0.484      P=0.063      P=0.349     |P=0.646N     P=0.495      P=0.500      (e)          | 
|POLY 6             |     P=0.060      P=0.458      P=0.023 *    P=0.246     |P=0.498      P=0.488      P=0.497      (e)          | 
|LOGISTIC REGRESSION|     P=0.618      P=0.415      P=0.351      P=0.945     |(e)          P=0.476      P=0.480      (e)          | 
|COCH-ARM / FISHERS |     P=0.351      P=0.500      P=0.122      P=0.500     |P=0.603N     P=0.500      P=0.496      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    0/60 (0%)    4/60 (7%)    1/60 (2%)   |0/60 (0%)    0/60 (0%)    0/59 (0%)    2/58 (3%)    | 
|POLY-3 RATE (b)    |     1/56.99      0/49.65      4/26.06      1/10.01     |0/56.31      0/54.01      0/56.26      2/38.84      | 
|POLY-3 PERCENT (g) |     1.8%         0.0%         15.4%        10.0%       |0.0%         0.0%         0.0%         5.2%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          410          358         |---          ---          ---          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009 **   P=0.585N     P=0.017 *    P=0.467     |P=0.014 *    (e)          (e)          P=0.100      | 
|POLY 3             |     P=0.071      P=0.527N     P=0.044 *    P=0.407     |P=0.037 *    (e)          (e)          P=0.166      | 
|POLY 1.5           |     P=0.113      P=0.516N     P=0.085      P=0.543     |P=0.039 *    (e)          (e)          P=0.194      | 
|POLY 6             |     P=0.184      P=0.542N     P=0.020 *    P=0.330     |P=0.046 *    (e)          (e)          P=0.131      | 
|LOGISTIC REGRESSION|     P=0.447N     (e)          P=0.451      P=0.983N    |P=0.071      (e)          (e)          P=0.282      | 
|COCH-ARM / FISHERS |     P=0.444      P=0.500N     P=0.182      P=0.752N    |P=0.044 *    (e)          (e)          P=0.239      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    2/60 (3%)    1/60 (2%)   |0/60 (0%)    0/60 (0%)    0/59 (0%)    0/58 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      2/24.86      1/10.01     |0/56.31      0/54.01      0/56.26      0/38.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.1%         10.0%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          410          358         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          P=0.143      P=0.467     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.081      (e)          P=0.115      P=0.280     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.077      (e)          P=0.158      P=0.349     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.262      (e)          P=0.080      P=0.246     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.586N     (e)          P=0.553      P=0.952     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.248      P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    2/59 (3%)    0/58 (0%)    0/60 (0%)   |2/59 (3%)    1/56 (2%)    0/58 (0%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/55.68      2/49.71      0/22.83      0/9.13      |2/55.85      1/52.43      0/55.37      0/38.93      | 
|POLY-3 PERCENT (g) |     0.0%         4.0%         0.0%         0.0%        |3.6%         1.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          641          ---          ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.432      P=0.174      (e)          (e)         |P=0.238N     P=0.543N     P=0.261N     P=0.793N     | 
|POLY 3             |     P=0.397      P=0.213      (e)          (e)         |P=0.100N     P=0.522N     P=0.240N     P=0.326N     | 
|POLY 1.5           |     P=0.637      P=0.225      (e)          (e)         |P=0.102N     P=0.519N     P=0.239N     P=0.282N     | 
|POLY 6             |     P=0.169      P=0.199      (e)          (e)         |P=0.105N     P=0.527N     P=0.244N     P=0.401N     | 
|LOGISTIC REGRESSION|     P=0.776      P=0.250      (e)          (e)         |P=0.238N     P=0.543N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.400N     P=0.252      (e)          (e)         |P=0.101N     P=0.520N     P=0.252N     P=0.248N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/58 (9%)    3/59 (5%)    0/58 (0%)    0/60 (0%)   |2/59 (3%)    3/56 (5%)    3/58 (5%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     5/55.68      3/49.39      0/22.83      0/9.13      |2/55.85      3/52.43      3/55.37      1/39.11      | 
|POLY-3 PERCENT (g) |     9.0%         6.1%         0.0%         0.0%        |3.6%         5.7%         5.4%         2.6%         | 
|TERMINAL (d)       |     5/52 (10%)   3/34 (9%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    3/46 (7%)    3/47 (6%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.736N     P=0.600N     P=1.000N     P=1.000N    |P=0.232      P=0.444      P=0.454      P=0.447      | 
|POLY 3             |     P=0.131N     P=0.425N     P=0.207N     P=0.439N    |P=0.500N     P=0.471      P=0.496      P=0.619N     | 
|POLY 1.5           |     P=0.036N*    P=0.390N     P=0.097N     P=0.208N    |P=0.426N     P=0.475      P=0.498      P=0.564N     | 
|POLY 6             |     P=0.359N     P=0.470N     P=0.413N     P=0.597N    |P=0.511      P=0.465      P=0.488      P=0.698N     | 
|LOGISTIC REGRESSION|     P=0.736N     P=0.600N     (e)          (e)         |P=0.428      P=0.444      P=0.454      P=0.724      | 
|COCH-ARM / FISHERS |     P=0.007N**   P=0.349N     P=0.029N*    P=0.026N*   |P=0.338N     P=0.475      P=0.492      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/58 (3%)    4/59 (7%)    1/58 (2%)    1/60 (2%)   |2/59 (3%)    0/56 (0%)    2/58 (3%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     2/55.68      4/49.39      1/23.22      1/9.97      |2/55.93      0/52.43      2/55.37      1/39.46      | 
|POLY-3 PERCENT (g) |     3.6%         8.1%         4.3%         10.0%       |3.6%         0.0%         3.6%         2.5%         | 
|TERMINAL (d)       |     2/52 (4%)    4/34 (12%)   0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      619          392         |710          ---          729 (T)      567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.166      P=0.041 *    P=0.378     |P=0.348      P=0.266N     P=0.655      P=0.620      | 
|POLY 3             |     P=0.315      P=0.285      P=0.661      P=0.483     |P=0.580      P=0.252N     P=0.690      P=0.617N     | 
|POLY 1.5           |     P=0.570      P=0.311      P=0.648N     P=0.663     |P=0.571N     P=0.250N     P=0.691      P=0.562N     | 
|POLY 6             |     P=0.165      P=0.252      P=0.499      P=0.374     |P=0.516      P=0.256N     P=0.683      P=0.695N     | 
|LOGISTIC REGRESSION|     P=0.120      P=0.166      P=0.631      P=0.986     |P=0.549N     P=0.251N     P=0.687      P=0.509N     | 
|COCH-ARM / FISHERS |     P=0.224N     P=0.348      P=0.500N     P=0.487N    |P=0.525N     P=0.261N     P=0.684      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    2/59 (3%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    1/56 (2%)    0/58 (0%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/55.68      2/50.01      0/22.83      0/9.13      |0/55.85      1/52.43      0/55.37      0/38.93      | 
|POLY-3 PERCENT (g) |     0.0%         4.0%         0.0%         0.0%        |0.0%         1.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          526          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.601      P=0.187      (e)          (e)         |P=0.830N     P=0.476      (e)          (e)          | 
|POLY 3             |     P=0.397      P=0.215      (e)          (e)         |P=0.561N     P=0.487      (e)          (e)          | 
|POLY 1.5           |     P=0.637      P=0.226      (e)          (e)         |P=0.566N     P=0.489      (e)          (e)          | 
|POLY 6             |     P=0.170      P=0.200      (e)          (e)         |P=0.600N     P=0.484      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.676N     P=0.284      (e)          (e)         |(e)          P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.400N     P=0.252      (e)          (e)         |P=0.565N     P=0.487      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/58 (2%)    3/59 (5%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    4/56 (7%)    1/58 (2%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     1/55.68      3/49.39      0/22.83      0/9.13      |0/55.85      4/52.43      1/55.37      0/38.93      | 
|POLY-3 PERCENT (g) |     1.8%         6.1%         0.0%         0.0%        |0.0%         7.6%         1.8%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    3/34 (9%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    4/46 (9%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331      P=0.169      P=1.000N     P=1.000N    |P=0.561      P=0.049 *    P=0.480      (e)          | 
|POLY 3             |     P=0.535      P=0.265      P=0.650N     P=0.719N    |P=0.424N     P=0.054      P=0.498      (e)          | 
|POLY 1.5           |     P=0.422N     P=0.285      P=0.587N     P=0.649N    |P=0.360N     P=0.055      P=0.499      (e)          | 
|POLY 6             |     P=0.235      P=0.239      P=0.714N     P=0.753N    |P=0.550N     P=0.052      P=0.495      (e)          | 
|LOGISTIC REGRESSION|     P=0.331      P=0.169      (e)          (e)         |(e)          P=0.049 *    P=0.480      (e)          | 
|COCH-ARM / FISHERS |     P=0.149N     P=0.316      P=0.500N     P=0.492N    |P=0.293N     P=0.053      P=0.496      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    1/59 (2%)    3/58 (5%)    0/60 (0%)   |0/59 (0%)    0/56 (0%)    0/58 (0%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     0/55.68      1/49.43      3/24.80      0/9.13      |0/55.85      0/52.43      0/55.37      1/39.35      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         12.1%        0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          717          410          ---         |---          ---          ---          608          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.428      P=0.026 *    (e)         |P=0.152      (e)          (e)          P=0.431      | 
|POLY 3             |     P=0.056      P=0.476      P=0.039 *    (e)         |P=0.164      (e)          (e)          P=0.432      | 
|POLY 1.5           |     P=0.173      P=0.488      P=0.063      (e)         |P=0.180      (e)          (e)          P=0.464      | 
|POLY 6             |     P=0.063      P=0.461      P=0.023 *    (e)         |P=0.180      (e)          (e)          P=0.385      | 
|LOGISTIC REGRESSION|     P=0.554N     P=0.467      P=0.390      (e)         |P=0.277      (e)          (e)          P=0.575      | 
|COCH-ARM / FISHERS |     P=0.625N     P=0.504      P=0.122      (e)         |P=0.202      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     56/58 (97%)  53/59 (90%)  34/58 (59%)  18/60 (30%) |9/59 (15%)   14/56 (25%)  10/58 (17%)  11/59 (19%)  | 
|POLY-3 RATE (b)    |     56/56.97     53/55.78     34/42.74     18/24.25    |9/55.85      14/55.01     10/56.60     11/43.33     | 
|POLY-3 PERCENT (g) |     98.3%        95.0%        79.5%        74.2%       |16.1%        25.5%        17.7%        25.4%        | 
|TERMINAL (d)       |     52/52 (100%) 34/34 (100%) 0/0 (0%)     0/0 (0%)    |9/52 (17%)   10/46 (22%)  6/47 (13%)   0/5 (0%)     | 
|FIRST INCIDENCE    |     592          451          303          345         |729 (T)      312          553          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.002 **   P=0.120      P=0.430      P<0.001 **   | 
|POLY 3             |     P<0.001N**   P=0.289N     P<0.001N**   P<0.001N**  |P=0.262      P=0.164      P=0.513      P=0.189      | 
|POLY 1.5           |     P<0.001N**   P=0.168N     P<0.001N**   P<0.001N**  |P=0.368      P=0.159      P=0.508      P=0.282      | 
|POLY 6             |     P=0.014N*    P=0.618N     P=0.018N*    P=0.463N    |P=0.150      P=0.164      P=0.508      P=0.087      | 
|LOGISTIC REGRESSION|     P=0.428N     P=0.560N     P=0.067N     P=0.759N    |P=0.300N     P=0.139      P=0.479      P=0.452      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.141N     P<0.001N**   P<0.001N**  |P=0.517      P=0.142      P=0.484      P=0.403      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Artery                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/58 (3%)    0/59 (0%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    0/56 (0%)    0/58 (0%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     2/56.14      0/49.39      0/22.83      0/9.13      |0/55.85      0/52.43      0/55.37      1/39.26      | 
|POLY-3 PERCENT (g) |     3.6%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     592          ---          ---          ---         |---          ---          ---          640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.536N     P=0.308N     P=0.921N     P=1.000N    |P=0.127      (e)          (e)          P=0.386      | 
|POLY 3             |     P=0.152N     P=0.267N     P=0.459N     P=0.600N    |P=0.164      (e)          (e)          P=0.432      | 
|POLY 1.5           |     P=0.116N     P=0.252N     P=0.353N     P=0.458N    |P=0.180      (e)          (e)          P=0.464      | 
|POLY 6             |     P=0.199N     P=0.288N     P=0.588N     P=0.677N    |P=0.180      (e)          (e)          P=0.384      | 
|LOGISTIC REGRESSION|     P=0.108N     P=0.200N     P=0.285N     P=0.822N    |P=0.257      (e)          (e)          P=0.546      | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.244N     P=0.248N     P=0.239N    |P=0.202      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    0/59 (0%)    2/58 (3%)    0/60 (0%)   |0/59 (0%)    1/56 (2%)    0/58 (0%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     0/55.68      0/49.39      2/24.24      0/9.13      |0/55.85      1/52.99      0/55.37      1/39.11      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.3%         0.0%        |0.0%         1.9%         0.0%         2.6%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          410          ---         |---          553          ---          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225      (e)          P=0.165      (e)         |P=0.298      P=0.500      (e)          P=0.278      | 
|POLY 3             |     P=0.167      (e)          P=0.114      (e)         |P=0.328      P=0.490      (e)          P=0.431      | 
|POLY 1.5           |     P=0.236      (e)          P=0.158      (e)         |P=0.364      P=0.490      (e)          P=0.463      | 
|POLY 6             |     P=0.317      (e)          P=0.080      (e)         |P=0.317      P=0.488      (e)          P=0.383      | 
|LOGISTIC REGRESSION|     P=0.425N     (e)          P=0.563      (e)         |P=0.512      P=0.463      (e)          P=0.446      | 
|COCH-ARM / FISHERS |     P=0.600      (e)          P=0.248      (e)         |P=0.409      P=0.487      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/58 (2%)    2/59 (3%)    5/58 (9%)    3/60 (5%)   |1/59 (2%)    3/56 (5%)    2/58 (3%)    10/59 (17%)  | 
|POLY-3 RATE (b)    |     1/55.68      2/49.40      5/25.11      3/11.71     |1/55.85      3/53.25      2/55.86      10/42.75     | 
|POLY-3 PERCENT (g) |     1.8%         4.1%         19.9%        25.6%       |1.8%         5.6%         3.6%         23.4%        | 
|TERMINAL (d)       |     1/52 (2%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      726          526          368         |729 (T)      553          624          444          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.361      P<0.001 **   P=0.070     |P<0.001 **   P=0.280      P=0.486      P<0.001 **   | 
|POLY 3             |     P=0.007 **   P=0.459      P=0.016 *    P=0.057     |P<0.001 **   P=0.289      P=0.500      P<0.001 **   | 
|POLY 1.5           |     P=0.022 *    P=0.479      P=0.037 *    P=0.111     |P<0.001 **   P=0.289      P=0.500      P=0.002 **   | 
|POLY 6             |     P=0.013 *    P=0.432      P=0.006 **   P=0.038 *   |P<0.001 **   P=0.287      P=0.496      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.087      P=0.382      P=0.026 *    P=0.859     |P=0.011 *    P=0.280      P=0.460      P=0.017 *    | 
|COCH-ARM / FISHERS |     P=0.229      P=0.506      P=0.103      P=0.322     |P<0.001 **   P=0.290      P=0.494      P=0.004 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Casts Protein                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    0/59 (0%)    0/58 (0%)    0/60 (0%)   |6/59 (10%)   8/56 (14%)   7/58 (12%)   6/59 (10%)   | 
|POLY-3 RATE (b)    |     0/55.68      0/49.39      0/22.83      0/9.13      |6/55.85      8/52.43      7/55.59      6/42.55      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |10.7%        15.3%        12.6%        14.1%        | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |6/52 (12%)   8/46 (17%)   6/47 (13%)   0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      673          403          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.014 *    P=0.297      P=0.428      P=0.061      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.411      P=0.340      P=0.496      P=0.425      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.514      P=0.346      P=0.498      P=0.520      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.276      P=0.330      P=0.485      P=0.282      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.400N     P=0.297      P=0.479      P=0.400N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.474N     P=0.348      P=0.487      P=0.619N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    1/59 (2%)    4/58 (7%)    0/60 (0%)   |0/59 (0%)    0/56 (0%)    0/58 (0%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     0/55.68      1/50.09      4/25.36      0/9.13      |0/55.85      0/52.43      0/55.37      1/39.60      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         15.8%        0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          485          497          ---         |---          ---          ---          507          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.490      P=0.020 *    (e)         |P=0.194      (e)          (e)          P=0.493      | 
|POLY 3             |     P=0.024 *    P=0.479      P=0.013 *    (e)         |P=0.164      (e)          (e)          P=0.433      | 
|POLY 1.5           |     P=0.110      P=0.490      P=0.025 *    (e)         |P=0.180      (e)          (e)          P=0.465      | 
|POLY 6             |     P=0.028 *    P=0.465      P=0.006 **   (e)         |P=0.178      (e)          (e)          P=0.386      | 
|LOGISTIC REGRESSION|     P=0.213N     P=0.489      P=0.238      (e)         |P=0.267      (e)          (e)          P=0.576      | 
|COCH-ARM / FISHERS |     P=0.600      P=0.504      P=0.059      (e)         |P=0.202      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/58 (0%)    1/59 (2%)    0/58 (0%)    2/60 (3%)   |0/59 (0%)    0/56 (0%)    1/58 (2%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/55.68      1/49.43      0/22.83      2/10.89     |0/55.85      0/52.43      1/55.43      0/38.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         0.0%         18.4%       |0.0%         0.0%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          717          ---          297         |---          ---          715          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.428      (e)          P=0.133     |P=0.540      (e)          P=0.480      (e)          | 
|POLY 3             |     P=0.118      P=0.476      (e)          P=0.079     |P=0.510      (e)          P=0.498      (e)          | 
|POLY 1.5           |     P=0.082      P=0.488      (e)          P=0.115     |P=0.604      (e)          P=0.499      (e)          | 
|POLY 6             |     P=0.237      P=0.461      (e)          P=0.065     |P=0.407      (e)          P=0.495      (e)          | 
|LOGISTIC REGRESSION|     P=0.477      P=0.467      (e)          P=0.838     |P=0.655      (e)          P=0.498      (e)          | 
|COCH-ARM / FISHERS |     P=0.145      P=0.504      (e)          P=0.256     |P=0.695      (e)          P=0.496      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/58 (2%)    6/59 (10%)   32/58 (55%)  35/60 (58%) |0/59 (0%)    1/56 (2%)    3/58 (5%)    35/59 (59%)  | 
|POLY-3 RATE (b)    |     1/56.01      6/50.19      32/41.46     35/38.67    |0/55.85      1/52.45      3/55.97      35/50.78     | 
|POLY-3 PERCENT (g) |     1.8%         12.0%        77.2%        90.5%       |0.0%         1.9%         5.4%         68.9%        | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     637          641          365          297         |---          723          624          444          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.027 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.476      P=0.122      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.042 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.487      P=0.120      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.049 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.489      P=0.120      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.034 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.485      P=0.118      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.068      P<0.001 **   P=0.014 *   |P<0.001 **   P=0.486      P=0.087      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.060      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.487      P=0.119      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    0/59 (0%)    2/57 (4%)    1/60 (2%)   |0/60 (0%)    1/59 (2%)    0/59 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     1/56.99      0/49.39      2/23.64      1/9.98      |0/56.31      1/53.32      0/56.29      3/40.47      | 
|POLY-3 PERCENT (g) |     1.8%         0.0%         8.5%         10.0%       |0.0%         1.9%         0.0%         7.4%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    0/47 (0%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          569          386         |---          729 (T)      ---          590          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009 **   P=0.585N     P=0.002 **   P=0.401     |P=0.002 **   P=0.476      (e)          P=0.010 *    | 
|POLY 3             |     P=0.266      P=0.528N     P=0.247      P=0.406     |P=0.033 *    P=0.489      (e)          P=0.072      | 
|POLY 1.5           |     P=0.252      P=0.517N     P=0.343      P=0.542     |P=0.037 *    P=0.492      (e)          P=0.092      | 
|POLY 6             |     P=0.532      P=0.542N     P=0.161      P=0.330     |P=0.037 *    P=0.486      (e)          P=0.050      | 
|LOGISTIC REGRESSION|     P=0.437      (e)          P=0.230      P=0.982     |P=0.043 *    P=0.476      (e)          P=0.103      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.504N     P=0.481      P=0.752N    |P=0.045 *    P=0.496      (e)          P=0.122      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    6/59 (10%)   4/57 (7%)    0/60 (0%)   |1/60 (2%)    6/59 (10%)   2/59 (3%)    6/60 (10%)   | 
|POLY-3 RATE (b)    |     0/56.99      6/49.39      4/24.68      0/9.13      |1/56.31      6/53.32      2/56.82      6/41.81      | 
|POLY-3 PERCENT (g) |     0.0%         12.2%        16.2%        0.0%        |1.8%         11.3%        3.5%         14.4%        | 
|TERMINAL (d)       |     0/52 (0%)    6/34 (18%)   0/0 (0%)     0/0 (0%)    |1/52 (2%)    6/46 (13%)   0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      553          ---         |729 (T)      729 (T)      624          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P<0.001 **   (e)         |P<0.001 **   P=0.042 *    P=0.490      P=0.003 **   | 
|POLY 3             |     P=0.007 **   P=0.010 *    P=0.011 *    (e)         |P=0.056      P=0.049 *    P=0.503      P=0.023 *    | 
|POLY 1.5           |     P=0.163      P=0.012 *    P=0.023 *    (e)         |P=0.076      P=0.051      P=0.502      P=0.036 *    | 
|POLY 6             |     P<0.001 **   P=0.008 **   P=0.006 **   (e)         |P=0.039 *    P=0.047 *    P=0.500      P=0.011 *    | 
|LOGISTIC REGRESSION|     P=0.010 *    P=0.004 **   P=0.050      (e)         |P=0.117      P=0.042 *    P=0.453      P=0.076      | 
|COCH-ARM / FISHERS |     P=0.294N     P=0.013 *    P=0.053      (e)         |P=0.114      P=0.054      P=0.494      P=0.057      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    2/59 (3%)    0/57 (0%)    0/60 (0%)   |1/60 (2%)    0/59 (0%)    2/59 (3%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     3/56.99      2/49.39      0/22.81      0/9.13      |1/56.31      0/53.32      2/56.29      4/40.49      | 
|POLY-3 PERCENT (g) |     5.3%         4.1%         0.0%         0.0%        |1.8%         0.0%         3.6%         9.9%         | 
|TERMINAL (d)       |     3/52 (6%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    2/47 (4%)    2/5 (40%)    | 
|FIRST INCIDENCE    |     729 (T)      728          ---          ---         |729 (T)      ---          729 (T)      567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.819      P=0.673      P=1.000N     P=1.000N    |P<0.001 **   P=0.524N     P=0.465      P<0.001 **   | 
|POLY 3             |     P=0.278N     P=0.564N     P=0.348N     P=0.533N    |P=0.023 *    P=0.511N     P=0.500      P=0.099      | 
|POLY 1.5           |     P=0.115N     P=0.540N     P=0.232N     P=0.350N    |P=0.029 *    P=0.508N     P=0.500      P=0.133      | 
|POLY 6             |     P=0.540N     P=0.596N     P=0.513N     P=0.641N    |P=0.019 *    P=0.514N     P=0.495      P=0.061      | 
|LOGISTIC REGRESSION|     P=0.815N     P=0.668N     (e)          (e)         |P=0.015 *    (e)          P=0.465      P=0.077      | 
|COCH-ARM / FISHERS |     P=0.041N*    P=0.508N     P=0.132N     P=0.122N    |P=0.041 *    P=0.504N     P=0.494      P=0.182      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Congestion Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    1/59 (2%)    0/57 (0%)    0/60 (0%)   |1/60 (2%)    2/59 (3%)    1/59 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/57.46      1/49.85      0/22.81      0/9.13      |1/56.31      2/53.34      1/56.29      0/39.77      | 
|POLY-3 PERCENT (g) |     3.5%         2.0%         0.0%         0.0%        |1.8%         3.8%         1.8%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    1/46 (2%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     592          592          ---          ---         |729 (T)      723          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.709N     P=0.591N     P=0.921N     P=1.000N    |P=0.644N     P=0.458      P=0.739      P=0.927N     | 
|POLY 3             |     P=0.328N     P=0.549N     P=0.464N     P=0.603N    |P=0.324N     P=0.481      P=0.760      P=0.567N     | 
|POLY 1.5           |     P=0.179N     P=0.530N     P=0.361N     P=0.464N    |P=0.289N     P=0.486      P=0.760N     P=0.536N     | 
|POLY 6             |     P=0.531N     P=0.573N     P=0.590N     P=0.679N    |P=0.401N     P=0.476      P=0.757      P=0.615N     | 
|LOGISTIC REGRESSION|     P=0.067N     P=0.442N     P=0.296N     P=0.826N    |P=0.575N     P=0.469      P=0.739      (e)          | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.506N     P=0.261N     P=0.248N    |P=0.248N     P=0.494      P=0.748      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    14/59 (24%)  1/57 (2%)    1/60 (2%)   |2/60 (3%)    3/59 (5%)    6/59 (10%)   28/60 (47%)  | 
|POLY-3 RATE (b)    |     3/57.33      14/50.61     1/23.34      1/9.93      |2/56.31      3/53.32      6/56.51      28/46.93     | 
|POLY-3 PERCENT (g) |     5.2%         27.7%        4.3%         10.1%       |3.6%         5.6%         10.6%        59.7%        | 
|TERMINAL (d)       |     2/52 (4%)    10/34 (29%)  0/0 (0%)     0/0 (0%)    |2/52 (4%)    3/46 (7%)    5/47 (11%)   3/5 (60%)    | 
|FIRST INCIDENCE    |     637          559          564          427         |729 (T)      729 (T)      673          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P=0.308      P=0.058     |P<0.001 **   P=0.444      P=0.111      P<0.001 **   | 
|POLY 3             |     P=0.052      P<0.001 **   P=0.628N     P=0.530     |P<0.001 **   P=0.475      P=0.136      P<0.001 **   | 
|POLY 1.5           |     P=0.514N     P=0.002 **   P=0.491N     P=0.626N    |P<0.001 **   P=0.481      P=0.136      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P=0.554      P=0.400     |P<0.001 **   P=0.468      P=0.132      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.073      P=0.002 **   P=0.685N     P=0.968N    |P<0.001 **   P=0.444      P=0.134      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.025N*    P=0.003 **   P=0.329N     P=0.309N    |P<0.001 **   P=0.492      P=0.131      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Focal Lymphoid                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/59 (0%)    0/57 (0%)    0/60 (0%)   |2/60 (3%)    5/59 (8%)    2/59 (3%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.39      0/22.81      0/9.13      |2/56.31      5/53.32      2/56.29      1/39.88      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |3.6%         9.4%         3.6%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    5/46 (11%)   2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.341      P=0.171      P=0.658      P=0.375      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.349N     P=0.196      P=0.693      P=0.616N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.288N     P=0.201      P=0.693N     P=0.562N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.454N     P=0.190      P=0.688      P=0.694N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.503      P=0.171      P=0.658      P=0.646      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.222N     P=0.213      P=0.684      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/60 (75%)  40/59 (68%)  24/57 (42%)  29/60 (48%) |45/60 (75%)  38/59 (64%)  37/59 (63%)  43/60 (72%)  | 
|POLY-3 RATE (b)    |     45/58.16     40/54.36     24/36.94     29/33.58    |45/56.92     38/55.59     37/57.30     43/52.85     | 
|POLY-3 PERCENT (g) |     77.4%        73.6%        65.0%        86.4%       |79.1%        68.4%        64.6%        81.4%        | 
|TERMINAL (d)       |     41/52 (79%)  27/34 (79%)  0/0 (0%)     0/0 (0%)    |42/52 (81%)  33/46 (72%)  32/47 (68%)  4/5 (80%)    | 
|FIRST INCIDENCE    |     592          451          365          312         |592          312          624          403          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.037 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.407N     P=0.273N     P<0.001 **   | 
|POLY 3             |     P=0.345      P=0.399N     P=0.121N     P=0.211     |P=0.371      P=0.136N     P=0.061N     P=0.473      | 
|POLY 1.5           |     P=0.139N     P=0.321N     P=0.009N**   P=0.338N    |P=0.482      P=0.134N     P=0.068N     P=0.570N     | 
|POLY 6             |     P=0.024 *    P=0.510N     P=0.512      P=0.024 *   |P=0.229      P=0.152N     P=0.066N     P=0.257      | 
|LOGISTIC REGRESSION|     P=0.189      P=0.481N     P=0.377N     P=0.311     |P=0.190      P=0.189N     P=0.070N     P=0.178      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.253N     P<0.001N**   P=0.002N**  |P=0.478N     P=0.145N     P=0.106N     P=0.418N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/59 (0%)    0/57 (0%)    0/60 (0%)   |0/60 (0%)    0/59 (0%)    1/59 (2%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     2/57.33      0/49.39      0/22.81      0/9.13      |0/56.31      0/53.32      1/56.45      3/40.20      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         1.8%         7.5%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     637          ---          ---          ---         |---          ---          690          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570N     P=0.312N     P=0.995N     P=1.000N    |P<0.001 **   (e)          P=0.493      P=0.004 **   | 
|POLY 3             |     P=0.157N     P=0.272N     P=0.464N     P=0.603N    |P=0.012 *    (e)          P=0.500      P=0.072      | 
|POLY 1.5           |     P=0.120N     P=0.258N     P=0.360N     P=0.464N    |P=0.015 *    (e)          P=0.500      P=0.092      | 
|POLY 6             |     P=0.204N     P=0.291N     P=0.590N     P=0.679N    |P=0.012 *    (e)          P=0.498      P=0.049 *    | 
|LOGISTIC REGRESSION|     P=0.222N     P=0.224N     P=0.531N     P=0.985N    |P=0.012 *    (e)          P=0.481      P=0.040 *    | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.252N     P=0.261N     P=0.248N    |P=0.021 *    (e)          P=0.496      P=0.122      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    15/59 (25%)  27/57 (47%)  30/60 (50%) |3/60 (5%)    0/59 (0%)    2/59 (3%)    13/60 (22%)  | 
|POLY-3 RATE (b)    |     1/56.99      15/52.33     27/38.30     30/34.75    |3/56.77      0/53.32      2/56.29      13/44.33     | 
|POLY-3 PERCENT (g) |     1.8%         28.7%        70.5%        86.3%       |5.3%         0.0%         3.6%         29.3%        | 
|TERMINAL (d)       |     1/52 (2%)    4/34 (12%)   0/0 (0%)     0/0 (0%)    |2/52 (4%)    0/46 (0%)    2/47 (4%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     729 (T)      526          419          297         |592          ---          729 (T)      444          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.139N     P=0.532N     P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.131N     P=0.504N     P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.128N     P=0.502N     P=0.002 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.135N     P=0.513N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.004 **   P<0.001 **   P<0.001 **   P=0.110     |P<0.001 **   P=0.119N     P=0.522N     P=0.021 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.125N     P=0.508N     P=0.007 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/59 (0%)    0/57 (0%)    0/60 (0%)   |0/60 (0%)    2/59 (3%)    0/59 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/57.95      0/49.39      0/22.81      0/9.13      |0/56.31      2/54.68      0/56.29      0/39.77      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |0.0%         3.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     263          ---          ---          ---         |---          266          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232N     P=0.286N     P=0.503N     P=0.500N    |P=0.443N     P=0.238      (e)          (e)          | 
|POLY 3             |     P=0.159N     P=0.275N     P=0.466N     P=0.604N    |P=0.444N     P=0.231      (e)          (e)          | 
|POLY 1.5           |     P=0.121N     P=0.261N     P=0.363N     P=0.466N    |P=0.428N     P=0.233      (e)          (e)          | 
|POLY 6             |     P=0.206N     P=0.293N     P=0.591N     P=0.679N    |P=0.499N     P=0.229      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.187N     P=0.033N*    P<0.001N**  |P=0.419N     P=0.307      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.252N     P=0.261N     P=0.248N    |P=0.405N     P=0.244      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/59 (0%)    0/57 (0%)    0/60 (0%)   |0/60 (0%)    0/59 (0%)    0/59 (0%)    6/60 (10%)   | 
|POLY-3 RATE (b)    |     2/56.99      0/49.39      0/22.81      0/9.13      |0/56.31      0/53.32      0/56.29      6/41.82      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         14.4%        | 
|TERMINAL (d)       |     2/52 (4%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.620N     P=0.336N     P=1.000      P=1.000N    |P<0.001 **   (e)          (e)          P=0.003 **   | 
|POLY 3             |     P=0.156N     P=0.271N     P=0.462N     P=0.602N    |P<0.001 **   (e)          (e)          P=0.006 **   | 
|POLY 1.5           |     P=0.120N     P=0.258N     P=0.359N     P=0.463N    |P<0.001 **   (e)          (e)          P=0.009 **   | 
|POLY 6             |     P=0.201N     P=0.288N     P=0.589N     P=0.679N    |P<0.001 **   (e)          (e)          P=0.003 **   | 
|LOGISTIC REGRESSION|     P=0.620N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          P=0.029 *    | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.252N     P=0.261N     P=0.248N    |P<0.001 **   (e)          (e)          P=0.014 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Syncytial Alteration Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/60 (27%)  26/59 (44%)  43/57 (75%)  39/60 (65%) |0/60 (0%)    0/59 (0%)    0/59 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     16/57.33     26/52.31     43/48.12     39/42.22    |0/56.31      0/53.32      0/56.29      0/39.77      | 
|POLY-3 PERCENT (g) |     27.9%        49.7%        89.4%        92.4%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     15/52 (29%)  18/34 (53%)  0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     637          463          303          277         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.018 *    P<0.001 **   P=0.088     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.036 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic Diffuse                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/60 (17%)  4/59 (7%)    0/57 (0%)    0/60 (0%)   |0/60 (0%)    2/59 (3%)    0/59 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     10/56.99     4/49.39      0/22.81      0/9.13      |0/56.31      2/53.32      0/56.29      0/39.77      | 
|POLY-3 PERCENT (g) |     17.6%        8.1%         0.0%         0.0%        |0.0%         3.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     10/52 (19%)  4/34 (12%)   0/0 (0%)     0/0 (0%)    |0/52 (0%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375N     P=0.269N     P=1.000N     P=1.000N    |P=0.735N     P=0.212      (e)          (e)          | 
|POLY 3             |     P=0.010N*    P=0.125N     P=0.065N     P=0.311N    |P=0.446N     P=0.226      (e)          (e)          | 
|POLY 1.5           |     P=0.002N**   P=0.104N     P=0.013N*    P=0.068N    |P=0.430N     P=0.229      (e)          (e)          | 
|POLY 6             |     P=0.050N     P=0.157N     P=0.271N     P=0.548N    |P=0.502N     P=0.222      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.375N     P=0.269N     (e)          (e)         |(e)          P=0.212      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.081N     P<0.001N**   P<0.001N**  |P=0.405N     P=0.244      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    5/59 (8%)    2/57 (4%)    1/60 (2%)   |1/60 (2%)    2/59 (3%)    2/59 (3%)    9/60 (15%)   | 
|POLY-3 RATE (b)    |     4/57.45      5/49.39      2/23.87      1/9.97      |1/56.31      2/53.32      2/56.51      9/43.00      | 
|POLY-3 PERCENT (g) |     7.0%         10.1%        8.4%         10.0%       |1.8%         3.8%         3.5%         20.9%        | 
|TERMINAL (d)       |     3/52 (6%)    5/34 (15%)   0/0 (0%)     0/0 (0%)    |1/52 (2%)    2/46 (4%)    1/47 (2%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     596          729 (T)      560          393         |729 (T)      729 (T)      673          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.266      P=0.057      P=0.358     |P<0.001 **   P=0.457      P=0.475      P<0.001 **   | 
|POLY 3             |     P=0.410      P=0.407      P=0.582      P=0.572     |P<0.001 **   P=0.481      P=0.501      P=0.002 **   | 
|POLY 1.5           |     P=0.424N     P=0.443      P=0.568N     P=0.518N    |P<0.001 **   P=0.486      P=0.501      P=0.004 **   | 
|POLY 6             |     P=0.226      P=0.362      P=0.369      P=0.421     |P<0.001 **   P=0.475      P=0.497      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.444      P=0.398      P=0.672N     P=0.807N    |P=0.003 **   P=0.457      P=0.493      P=0.021 *    | 
|COCH-ARM / FISHERS |     P=0.082N     P=0.489      P=0.364N     P=0.182N    |P<0.001 **   P=0.494      P=0.494      P=0.008 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Depletion Glycogen                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/59 (2%)    0/57 (0%)    3/60 (5%)   |0/60 (0%)    0/59 (0%)    0/59 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/49.39      0/22.81      3/11.81     |0/56.31      0/53.32      0/56.29      1/40.30      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         0.0%         25.4%       |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          277         |---          ---          ---          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.415      (e)          P=0.093     |P=0.186      (e)          (e)          P=0.481      | 
|POLY 3             |     P=0.043 *    P=0.472      (e)          P=0.022 *   |P=0.165      (e)          (e)          P=0.435      | 
|POLY 1.5           |     P=0.023 *    P=0.483      (e)          P=0.038 *   |P=0.180      (e)          (e)          P=0.466      | 
|POLY 6             |     P=0.121      P=0.457      (e)          P=0.016 *   |P=0.177      (e)          (e)          P=0.388      | 
|LOGISTIC REGRESSION|     P=0.475      P=0.415      (e)          P=0.675     |P=0.252      (e)          (e)          P=0.584      | 
|COCH-ARM / FISHERS |     P=0.045 *    P=0.496      (e)          P=0.122     |P=0.200      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    2/59 (3%)    5/57 (9%)    2/60 (3%)   |2/60 (3%)    0/59 (0%)    2/59 (3%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/57.04      2/50.32      5/25.85      2/10.85     |2/57.56      0/53.32      2/56.35      0/39.77      | 
|POLY-3 PERCENT (g) |     1.8%         4.0%         19.3%        18.4%       |3.5%         0.0%         3.6%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     719          542          451          358         |483          ---          715          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.423      P=0.002 **   P=0.149     |P=0.405N     P=0.246N     P=0.680      P=0.256N     | 
|POLY 3             |     P=0.013 *    P=0.457      P=0.015 *    P=0.158     |P=0.322N     P=0.255N     P=0.686      P=0.328N     | 
|POLY 1.5           |     P=0.045 *    P=0.473      P=0.035 *    P=0.252     |P=0.287N     P=0.250N     P=0.689      P=0.283N     | 
|POLY 6             |     P=0.019 *    P=0.436      P=0.006 **   P=0.117     |P=0.404N     P=0.261N     P=0.678      P=0.403N     | 
|LOGISTIC REGRESSION|     P=0.363N     P=0.561      P=0.306      P=0.933     |P=0.186N     P=0.175N     P=0.543      P=0.143N     | 
|COCH-ARM / FISHERS |     P=0.373      P=0.494      P=0.092      P=0.500     |P=0.248N     P=0.252N     P=0.684      P=0.248N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/59 (0%)    0/57 (0%)    2/60 (3%)   |0/60 (0%)    0/59 (0%)    0/59 (0%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.39      0/22.81      2/10.89     |0/56.31      0/53.32      0/56.29      4/41.83      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         18.4%       |0.0%         0.0%         0.0%         9.6%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          354         |---          ---          ---          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.034 *    (e)          (e)          P=0.202     |P=0.002 **   (e)          (e)          P=0.044 *    | 
|POLY 3             |     P=0.149      (e)          (e)          P=0.077     |P=0.002 **   (e)          (e)          P=0.033 *    | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.112     |P=0.002 **   (e)          (e)          P=0.044 *    | 
|POLY 6             |     P=0.506      (e)          (e)          P=0.063     |P=0.003 **   (e)          (e)          P=0.020 *    | 
|LOGISTIC REGRESSION|     P=0.446      (e)          (e)          P=0.845     |P=0.011 *    (e)          (e)          P=0.127      | 
|COCH-ARM / FISHERS |     P=0.048 *    (e)          (e)          P=0.248     |P=0.003 **   (e)          (e)          P=0.059      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    1/60 (2%)    1/60 (2%)   |1/60 (2%)    2/60 (3%)    1/59 (2%)    1/57 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/50.40      1/24.12      1/9.96      |1/56.31      2/54.68      1/56.37      1/37.60      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         4.2%         10.0%       |1.8%         3.7%         1.8%         2.7%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          463          517          405         |729 (T)      608          701          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    P=0.497      P=0.417      P=0.304     |P=0.412      P=0.477      P=0.743      P=0.300      | 
|POLY 3             |     P=0.139      P=0.476      P=0.353      P=0.280     |P=0.563      P=0.490      P=0.760N     P=0.663      | 
|POLY 1.5           |     P=0.163      P=0.486      P=0.415      P=0.348     |P=0.590N     P=0.493      P=0.760N     P=0.706      | 
|POLY 6             |     P=0.221      P=0.462      P=0.288      P=0.246     |P=0.504      P=0.486      P=0.758      P=0.591      | 
|LOGISTIC REGRESSION|     P=0.466N     P=0.482      P=0.736      P=0.940     |P=0.528N     P=0.518      P=0.761      P=0.585      | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.549N     P=0.500      P=0.748      P=0.739      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    0/60 (0%)    1/60 (2%)    5/60 (8%)   |2/60 (3%)    1/60 (2%)    1/59 (2%)    2/57 (4%)    | 
|POLY-3 RATE (b)    |     1/57.95      0/49.65      1/24.35      5/13.49     |2/56.32      1/54.01      1/56.26      2/37.88      | 
|POLY-3 PERCENT (g) |     1.7%         0.0%         4.1%         37.1%       |3.6%         1.9%         1.8%         5.3%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    1/46 (2%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     263          ---          365          277         |725          729 (T)      729 (T)      671          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.500N     P=0.758      P=0.034 *   |P=0.124      P=0.545N     P=0.537N     P=0.158      | 
|POLY 3             |     P=0.014 *    P=0.531N     P=0.548      P=0.005 **  |P=0.450      P=0.515N     P=0.500N     P=0.543      | 
|POLY 1.5           |     P=0.005 **   P=0.518N     P=0.650      P=0.016 *   |P=0.487      P=0.509N     P=0.500N     P=0.607      | 
|POLY 6             |     P=0.077      P=0.546N     P=0.422      P=0.003 **  |P=0.432      P=0.522N     P=0.506N     P=0.443      | 
|LOGISTIC REGRESSION|     P=0.446N     (e)          P=0.602N     P=0.532N    |P=0.374      P=0.533N     P=0.526N     P=0.482      | 
|COCH-ARM / FISHERS |     P=0.012 *    P=0.500N     P=0.752N     P=0.103     |P=0.536      P=0.500N     P=0.506N     P=0.671      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    1/60 (2%)   |1/60 (2%)    0/60 (0%)    0/59 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      2/49.65      0/23.48      1/10.00     |1/56.31      0/54.01      0/56.26      0/37.46      | 
|POLY-3 PERCENT (g) |     0.0%         4.0%         0.0%         10.0%       |1.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    2/34 (6%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          371         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047 *    P=0.151      (e)          P=0.441     |P=0.473N     P=0.524N     P=0.520N     P=0.927N     | 
|POLY 3             |     P=0.201      P=0.208      (e)          P=0.280     |P=0.250N     P=0.508N     P=0.500N     P=0.578N     | 
|POLY 1.5           |     P=0.288      P=0.221      (e)          P=0.349     |P=0.282N     P=0.505N     P=0.500N     P=0.547N     | 
|POLY 6             |     P=0.150      P=0.194      (e)          P=0.246     |P=0.236N     P=0.512N     P=0.503N     P=0.625N     | 
|LOGISTIC REGRESSION|     P=0.273      P=0.151      (e)          P=0.950     |P=0.473N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.248      (e)          P=0.500     |P=0.312N     P=0.500N     P=0.504N     P=0.513N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    2/60 (3%)    0/59 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      2/54.01      0/56.26      0/37.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         3.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.735N     P=0.212      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.455N     P=0.228      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.440N     P=0.232      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.512N     P=0.224      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.212      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.416N     P=0.248      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |1/60 (2%)    1/60 (2%)    2/59 (3%)    1/57 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |1/56.38      1/54.01      2/56.26      1/37.66      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |1.8%         1.9%         3.6%         2.7%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |710          729 (T)      729 (T)      677          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.158      P=0.734      P=0.463      P=0.435      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.416      P=0.751      P=0.499      P=0.663      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.489      P=0.754      P=0.500      P=0.706      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.337      P=0.746      P=0.493      P=0.592      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.381      P=0.753      P=0.497      P=0.697      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.573      P=0.752N     P=0.494      P=0.739      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    4/60 (7%)    9/60 (15%)   3/60 (5%)   |0/60 (0%)    0/60 (0%)    0/59 (0%)    9/57 (16%)   | 
|POLY-3 RATE (b)    |     0/56.99      4/50.86      9/28.99      3/11.56     |0/56.31      0/54.01      0/56.26      9/40.48      | 
|POLY-3 PERCENT (g) |     0.0%         7.9%         31.1%        26.0%       |0.0%         0.0%         0.0%         22.2%        | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          526          410          391         |---          ---          ---          507          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.042 *    P<0.001 **   P=0.004 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.048 *    P<0.001 **   P=0.021 *   |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 1.5           |     P=0.002 **   P=0.054      P<0.001 **   P=0.037 *   |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.043 *    P<0.001 **   P=0.016 *   |P<0.001 **   (e)          (e)          P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.559      P=0.088      P=0.035 *    P=0.541     |P<0.001 **   (e)          (e)          P=0.005 **   | 
|COCH-ARM / FISHERS |     P=0.191      P=0.059      P<0.001 **   P=0.122     |P<0.001 **   (e)          (e)          P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    3/60 (5%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/59 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      3/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/56.26      0/37.46      | 
|POLY-3 PERCENT (g) |     0.0%         6.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    3/34 (9%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.165      P=0.058      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.276      P=0.097      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.599      P=0.106      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.058      P=0.086      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.058      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.312N     P=0.122      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    1/60 (2%)    3/60 (5%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     1/57.04      1/49.65      3/25.25      0/9.13      |0/56.31      0/54.01      0/57.18      3/40.79      | 
|POLY-3 PERCENT (g) |     1.8%         2.0%         11.9%        0.0%        |0.0%         0.0%         0.0%         7.4%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     719          729 (T)      523          ---         |---          ---          ---          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.667      P=0.031 *    P=1.000N    |P=0.002 **   (e)          (e)          P=0.039 *    | 
|POLY 3             |     P=0.191      P=0.729      P=0.110      P=0.721N    |P=0.010 *    (e)          (e)          P=0.073      | 
|POLY 1.5           |     P=0.371      P=0.743      P=0.178      P=0.654N    |P=0.010 *    (e)          (e)          P=0.093      | 
|POLY 6             |     P=0.212      P=0.710      P=0.060      P=0.754N    |P=0.012 *    (e)          (e)          P=0.051      | 
|LOGISTIC REGRESSION|     P=0.748      P=0.703      P=0.441      (e)         |P=0.024 *    (e)          (e)          P=0.156      | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.752N     P=0.309      P=0.500N    |P=0.012 *    (e)          (e)          P=0.122      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/57.18      2/40.20      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          629          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.005 **   (e)          (e)          P=0.049 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.038 *    (e)          (e)          P=0.172      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.201      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.136      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.051      (e)          (e)          P=0.202      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.248      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    2/55 (4%)    0/56 (0%)    0/53 (0%)   |0/53 (0%)    0/58 (0%)    1/57 (2%)    1/57 (2%)    | 
|POLY-3 RATE (b)    |     1/56.99      2/46.32      0/21.95      0/7.99      |0/50.24      0/53.22      1/54.43      1/38.05      | 
|POLY-3 PERCENT (g) |     1.8%         4.3%         0.0%         0.0%        |0.0%         0.0%         1.8%         2.6%         | 
|TERMINAL (d)       |     1/52 (2%)    2/32 (6%)    0/0 (0%)     0/0 (0%)    |0/46 (0%)    0/46 (0%)    0/46 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          715          640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.568      P=0.334      P=1.000N     P=1.000N    |P=0.075      (e)          P=0.480      P=0.386      | 
|POLY 3             |     P=0.649      P=0.428      P=0.659N     P=0.733N    |P=0.157      (e)          P=0.516      P=0.446      | 
|POLY 1.5           |     P=0.432N     P=0.446      P=0.599N     P=0.671N    |P=0.194      (e)          P=0.516      P=0.478      | 
|POLY 6             |     P=0.442      P=0.406      P=0.720N     P=0.762N    |P=0.130      (e)          P=0.513      P=0.398      | 
|LOGISTIC REGRESSION|     P=0.568      P=0.334      (e)          (e)         |P=0.253      (e)          P=0.515      P=0.574      | 
|COCH-ARM / FISHERS |     P=0.206N     P=0.467      P=0.517N     P=0.531N    |P=0.243      (e)          P=0.518      P=0.518      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/55 (0%)    1/56 (2%)    0/53 (0%)   |3/53 (6%)    1/58 (2%)    2/57 (4%)    4/57 (7%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/46.32      1/22.67      0/7.99      |3/50.70      1/53.22      2/54.37      4/38.36      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |5.9%         1.9%         3.7%         10.4%        | 
|TERMINAL (d)       |     0/52 (0%)    0/32 (0%)    0/0 (0%)     0/0 (0%)    |2/46 (4%)    1/46 (2%)    2/46 (4%)    2/5 (40%)    | 
|FIRST INCIDENCE    |     ---          ---          476          ---         |592          729 (T)      729 (T)      583          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.463      (e)          P=0.455      (e)         |P=0.011 *    P=0.309N     P=0.495N     P=0.018 *    | 
|POLY 3             |     P=0.411      (e)          P=0.343      (e)         |P=0.227      P=0.288N     P=0.468N     P=0.353      | 
|POLY 1.5           |     P=0.406      (e)          P=0.403      (e)         |P=0.260      P=0.283N     P=0.466N     P=0.438      | 
|POLY 6             |     P=0.634      (e)          P=0.282      (e)         |P=0.210      P=0.295N     P=0.477N     P=0.239      | 
|LOGISTIC REGRESSION|     P=0.674N     (e)          P=0.757      (e)         |P=0.228      P=0.266N     P=0.483N     P=0.404      | 
|COCH-ARM / FISHERS |     P=0.681      (e)          P=0.483      (e)         |P=0.313      P=0.276N     P=0.465N     P=0.541      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/55 (2%)    0/56 (0%)    0/53 (0%)   |6/53 (11%)   2/58 (3%)    2/57 (4%)    2/57 (4%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/46.32      0/21.95      0/7.99      |6/50.24      2/53.41      2/54.37      2/37.96      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |11.9%        3.7%         3.7%         5.3%         | 
|TERMINAL (d)       |     0/52 (0%)    1/32 (3%)    0/0 (0%)     0/0 (0%)    |6/46 (13%)   1/46 (2%)    2/46 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      679          729 (T)      688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.784      P=0.403      (e)          (e)         |P=0.573      P=0.141N     P=0.135N     P=0.262      | 
|POLY 3             |     P=0.587      P=0.459      (e)          (e)         |P=0.137N     P=0.115N     P=0.110N     P=0.245N     | 
|POLY 1.5           |     P=0.690      P=0.469      (e)          (e)         |P=0.122N     P=0.113N     P=0.110N     P=0.174N     | 
|POLY 6             |     P=0.467      P=0.446      (e)          (e)         |P=0.156N     P=0.118N     P=0.114N     P=0.382N     | 
|LOGISTIC REGRESSION|     (e)          P=0.403      (e)          (e)         |P=0.316N     P=0.119N     P=0.135N     P=0.662      | 
|COCH-ARM / FISHERS |     P=0.583N     P=0.478      (e)          (e)         |P=0.101N     P=0.108N     P=0.113N     P=0.113N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/3 (0%)     0/4 (0%)     0/7 (0%)     0/1 (0%)    |0/6 (0%)     0/3 (0%)     2/10 (20%)   0/11 (0%)    | 
|POLY-3 RATE (b)    |     0/2.88       0/3.68       0/2.49       0/0.16      |0/5.98       0/2.59       2/9.43       0/7.61       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         21.2%        0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/5 (0%)     0/2 (0%)     1/5 (20%)    0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          624          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.382      (e)          P=0.246      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.586      (e)          P=0.335      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.665N     (e)          P=0.343      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.438      (e)          P=0.321      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.567N     (e)          P=0.658      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.601N     (e)          P=0.375      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/3 (0%)     0/4 (0%)     0/7 (0%)     0/1 (0%)    |0/6 (0%)     0/3 (0%)     2/10 (20%)   1/11 (9%)    | 
|POLY-3 RATE (b)    |     0/2.88       0/3.68       0/2.49       0/0.16      |0/5.98       0/2.59       2/9.05       1/8.10       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         22.1%        12.3%        | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/5 (0%)     0/2 (0%)     2/5 (40%)    0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      583          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.031 *    (e)          P=0.227      P=0.421      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.321      (e)          P=0.323      P=0.562      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.384      (e)          P=0.337      P=0.590      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.228      (e)          P=0.301      P=0.511      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.479      (e)          P=0.227      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.452      (e)          P=0.375      P=0.647      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/12 (25%)   2/12 (17%)   2/42 (5%)    0/38 (0%)   |1/11 (9%)    0/9 (0%)     0/9 (0%)     2/34 (6%)    | 
|POLY-3 RATE (b)    |     3/11.54      2/10.90      2/18.55      0/6.18      |1/10.98      0/7.77       0/7.77       2/24.95      | 
|POLY-3 PERCENT (g) |     26.0%        18.4%        10.8%        0.0%        |9.1%         0.0%         0.0%         8.0%         | 
|TERMINAL (d)       |     3/11 (27%)   1/7 (14%)    0/0 (0%)     0/0 (0%)    |1/10 (10%)   0/6 (0%)     0/5 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      717          492          ---         |729 (T)      ---          ---          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198      P=0.675      P=0.160      P=1.000N    |P=0.169      P=0.602N     P=0.638N     P=0.366      | 
|POLY 3             |     P=0.107N     P=0.528N     P=0.255N     P=0.272N    |P=0.545      P=0.568N     P=0.568N     P=0.716N     | 
|POLY 1.5           |     P=0.014N*    P=0.515N     P=0.122N     P=0.048N*   |P=0.576      P=0.556N     P=0.556N     P=0.673N     | 
|POLY 6             |     P=0.507N     P=0.550N     P=0.576N     P=0.580N    |P=0.492      P=0.584N     P=0.586N     P=0.716      | 
|LOGISTIC REGRESSION|     P=0.359N     P=0.634N     P=0.432N     (e)         |P=0.392N     (e)          (e)          P=0.294N     | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.500N     P=0.067N     P=0.011N*   |P=0.609      P=0.550N     P=0.550N     P=0.578N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/12 (25%)   1/12 (8%)    0/42 (0%)    0/38 (0%)   |0/11 (0%)    0/9 (0%)     1/9 (11%)    0/34 (0%)    | 
|POLY-3 RATE (b)    |     3/12.00      1/10.85      0/17.23      0/6.18      |0/10.98      0/7.77       1/7.77       0/23.82      | 
|POLY-3 PERCENT (g) |     25.0%        9.2%         0.0%         0.0%        |0.0%         0.0%         12.9%        0.0%         | 
|TERMINAL (d)       |     2/11 (18%)   1/7 (14%)    0/0 (0%)     0/0 (0%)    |0/10 (0%)    0/6 (0%)     1/5 (20%)    0/4 (0%)     | 
|FIRST INCIDENCE    |     592          729 (T)      ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.626N     P=0.451N     P=0.942N     P=1.000N    |P=0.579      (e)          P=0.362      (e)          | 
|POLY 3             |     P=0.008N**   P=0.333N     P=0.035N*    P=0.286N    |P=0.678N     (e)          P=0.431      (e)          | 
|POLY 1.5           |     P<0.001N**   P=0.316N     P=0.008N**   P=0.052N    |P=0.642N     (e)          P=0.444      (e)          | 
|POLY 6             |     P=0.086N     P=0.362N     P=0.212N     P=0.583N    |P=0.627      (e)          P=0.412      (e)          | 
|LOGISTIC REGRESSION|     P=0.126N     P=0.245N     P=0.138N     P=0.823N    |(e)          (e)          P=0.362      (e)          | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.295N     P=0.009N**   P=0.011N*   |P=0.601N     (e)          P=0.450      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/12 (50%)   1/12 (8%)    1/42 (2%)    0/38 (0%)   |6/11 (55%)   5/9 (56%)    4/9 (44%)    0/34 (0%)    | 
|POLY-3 RATE (b)    |     6/11.54      1/11.00      1/17.81      0/6.18      |6/10.98      5/7.77       4/8.70       0/23.82      | 
|POLY-3 PERCENT (g) |     52.0%        9.1%         5.6%         0.0%        |54.6%        64.4%        46.0%        0.0%         | 
|TERMINAL (d)       |     6/11 (55%)   0/7 (0%)     0/0 (0%)     0/0 (0%)    |6/10 (60%)   5/6 (83%)    2/5 (40%)    0/4 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      690          544          ---         |729 (T)      729 (T)      553          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.628N     P=0.131N     P=0.358      P=1.000N    |P=0.076N     P=0.343      P=0.566      P=0.081N     | 
|POLY 3             |     P<0.001N**   P=0.029N*    P<0.001N**   P=0.060N    |P<0.001N**   P=0.521      P=0.527N     P<0.001N**   | 
|POLY 1.5           |     P<0.001N**   P=0.028N*    P<0.001N**   P<0.001N**  |P<0.001N**   P=0.581      P=0.514N     P<0.001N**   | 
|POLY 6             |     P<0.001N**   P=0.033N*    P=0.062N     P=0.497N    |P<0.001N**   P=0.432      P=0.551N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.076N     P=0.052N     P=0.491N     (e)         |P<0.001N**   P=0.343      P=0.298N     (e)          | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.034N*    P<0.001N**   P<0.001N**  |P<0.001N**   P=0.658      P=0.500N     P<0.001N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Mucosa, Glands                                                                                                             | 
|     Dilatation Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    3/59 (5%)    1/57 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      3/56.29      1/38.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         0.0%         0.0%        |0.0%         0.0%         5.3%         2.6%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    3/47 (6%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          729 (T)      690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.791      P=0.415      (e)          (e)         |P=0.012 *    (e)          P=0.104      P=0.230      | 
|POLY 3             |     P=0.604      P=0.473      (e)          (e)         |P=0.107      (e)          P=0.120      P=0.424      | 
|POLY 1.5           |     P=0.705      P=0.484      (e)          (e)         |P=0.159      (e)          P=0.120      P=0.455      | 
|POLY 6             |     P=0.483      P=0.458      (e)          (e)         |P=0.060      (e)          P=0.117      P=0.379      | 
|LOGISTIC REGRESSION|     (e)          P=0.415      (e)          (e)         |P=0.061      (e)          P=0.104      P=0.423      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.234      (e)          P=0.119      P=0.487      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/59 (5%)    2/56 (4%)    1/56 (2%)    0/56 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/55.31      2/51.28      1/53.29      0/36.99      | 
|POLY-3 PERCENT (g) |                                                        |5.4%         3.9%         1.9%         0.0%         | 
|TERMINAL (d)       |                                                        |3/51 (6%)    1/45 (2%)    1/44 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      721          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.283N     P=0.554N     P=0.360N     P=0.684N     | 
|POLY 3             |                                                        |P=0.094N     P=0.534N     P=0.319N     P=0.208N     | 
|POLY 1.5           |                                                        |P=0.082N     P=0.529N     P=0.319N     P=0.167N     | 
|POLY 6             |                                                        |P=0.122N     P=0.541N     P=0.325N     P=0.285N     | 
|LOGISTIC REGRESSION|                                                        |P=0.231N     P=0.552N     P=0.360N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.067N     P=0.525N     P=0.329N     P=0.132N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/59 (20%)  18/56 (32%)  13/56 (23%)  11/56 (20%)  | 
|POLY-3 RATE (b)    |                                                        |12/55.77     18/51.50     13/53.94     11/40.00     | 
|POLY-3 PERCENT (g) |                                                        |21.5%        35.0%        24.1%        27.5%        | 
|TERMINAL (d)       |                                                        |11/51 (22%)  17/45 (38%)  10/44 (23%)  1/5 (20%)    | 
|FIRST INCIDENCE    |                                                        |592          660          671          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   P=0.073      P=0.368      P<0.001 **   | 
|POLY 3             |                                                        |P=0.425      P=0.090      P=0.462      P=0.335      | 
|POLY 1.5           |                                                        |P=0.501N     P=0.098      P=0.462      P=0.471      | 
|POLY 6             |                                                        |P=0.242      P=0.080      P=0.450      P=0.168      | 
|LOGISTIC REGRESSION|                                                        |P=0.381      P=0.090      P=0.455      P=0.378      | 
|COCH-ARM / FISHERS |                                                        |P=0.327N     P=0.110      P=0.441      P=0.556N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/59 (2%)    2/56 (4%)    0/56 (0%)    1/56 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/55.31      2/52.40      0/53.29      1/37.40      | 
|POLY-3 PERCENT (g) |                                                        |1.8%         3.8%         0.0%         2.7%         | 
|TERMINAL (d)       |                                                        |1/51 (2%)    0/45 (0%)    0/44 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      343          ---          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.620      P=0.475      P=0.529N     P=0.489      | 
|POLY 3             |                                                        |P=0.535N     P=0.481      P=0.507N     P=0.666      | 
|POLY 1.5           |                                                        |P=0.530N     P=0.483      P=0.507N     P=0.707      | 
|POLY 6             |                                                        |P=0.548N     P=0.478      P=0.511N     P=0.598      | 
|LOGISTIC REGRESSION|                                                        |P=0.380N     P=0.499      (e)          P=0.767      | 
|COCH-ARM / FISHERS |                                                        |P=0.513N     P=0.480      P=0.513N     P=0.739      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Interstitial Cell                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/59 (0%)    0/56 (0%)    2/56 (4%)    0/56 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/55.31      0/51.25      2/53.29      0/36.99      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         3.8%         0.0%         | 
|TERMINAL (d)       |                                                        |0/51 (0%)    0/45 (0%)    2/44 (5%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.260      (e)          P=0.207      (e)          | 
|POLY 3             |                                                        |P=0.367      (e)          P=0.229      (e)          | 
|POLY 1.5           |                                                        |P=0.474      (e)          P=0.230      (e)          | 
|POLY 6             |                                                        |P=0.245      (e)          P=0.226      (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.207      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.586      (e)          P=0.235      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Diffuse                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    0/59 (0%)    0/59 (0%)    0/58 (0%)   |0/60 (0%)    2/57 (4%)    1/58 (2%)    1/57 (2%)    | 
|POLY-3 RATE (b)    |     0/56.29      0/49.39      0/23.21      0/8.80      |0/56.31      2/52.86      1/55.63      1/38.14      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         3.8%         1.8%         2.6%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          660          661          610          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.275      P=0.223      P=0.507      P=0.421      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.347      P=0.224      P=0.498      P=0.424      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.411      P=0.225      P=0.497      P=0.455      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.280      P=0.222      P=0.496      P=0.379      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.559      P=0.229      P=0.449      P=0.560      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.488      P=0.235      P=0.492      P=0.487      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/59 (2%)    1/59 (2%)    0/59 (0%)    0/58 (0%)   |2/60 (3%)    1/57 (2%)    0/58 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     1/56.29      1/49.54      0/23.21      0/8.80      |2/56.31      1/52.60      0/55.37      0/37.73      | 
|POLY-3 PERCENT (g) |     1.8%         2.0%         0.0%         0.0%        |3.6%         1.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      690          ---          ---         |729 (T)      712          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.880      P=0.678      P=1.000N     P=1.000N    |P=0.235N     P=0.537N     P=0.261N     P=0.793N     | 
|POLY 3             |     P=0.605N     P=0.731      P=0.650N     P=0.723N    |P=0.103N     P=0.524N     P=0.241N     P=0.335N     | 
|POLY 1.5           |     P=0.369N     P=0.744      P=0.587N     P=0.656N    |P=0.106N     P=0.521N     P=0.241N     P=0.292N     | 
|POLY 6             |     P=0.802      P=0.714      P=0.714N     P=0.756N    |P=0.106N     P=0.527N     P=0.244N     P=0.408N     | 
|LOGISTIC REGRESSION|     P=0.875N     P=0.745      (e)          (e)         |P=0.160N     P=0.527N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.238N     P=0.752N     P=0.500N     P=0.504N    |P=0.105N     P=0.519N     P=0.256N     P=0.261N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    1/59 (2%)    0/59 (0%)    0/58 (0%)   |2/60 (3%)    0/57 (0%)    0/58 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     0/56.29      1/49.54      0/23.21      0/8.80      |2/56.31      0/52.53      0/55.37      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         0.0%         0.0%        |3.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          690          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.804      P=0.440      (e)          (e)         |P=0.205N     P=0.266N     P=0.261N     P=0.793N     | 
|POLY 3             |     P=0.605      P=0.475      (e)          (e)         |P=0.095N     P=0.253N     P=0.241N     P=0.335N     | 
|POLY 1.5           |     P=0.703      P=0.486      (e)          (e)         |P=0.108N     P=0.251N     P=0.241N     P=0.292N     | 
|POLY 6             |     P=0.485      P=0.460      (e)          (e)         |P=0.086N     P=0.256N     P=0.244N     P=0.408N     | 
|LOGISTIC REGRESSION|     P=0.914      P=0.506      (e)          (e)         |P=0.205N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.570N     P=0.500      (e)          (e)         |P=0.119N     P=0.261N     P=0.256N     P=0.261N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/53 (4%)    1/50 (2%)    0/50 (0%)    0/46 (0%)   |0/58 (0%)    1/58 (2%)    0/53 (0%)    0/53 (0%)    | 
|POLY-3 RATE (b)    |     2/51.28      1/41.29      0/19.25      0/6.89      |0/55.19      1/53.17      0/50.37      0/35.53      | 
|POLY-3 PERCENT (g) |     3.9%         2.4%         0.0%         0.0%        |0.0%         1.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/47 (4%)    1/29 (3%)    0/0 (0%)     0/0 (0%)    |0/51 (0%)    1/46 (2%)    0/42 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.849N     P=0.666N     P=1.000N     P=1.000N    |P=0.836N     P=0.479      (e)          (e)          | 
|POLY 3             |     P=0.359N     P=0.575N     P=0.476N     P=0.622N    |P=0.580N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.197N     P=0.553N     P=0.369N     P=0.497N    |P=0.585N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.574N     P=0.599N     P=0.603N     P=0.688N    |P=0.613N     P=0.489      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.849N     P=0.666N     (e)          (e)         |(e)          P=0.479      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.114N     P=0.522N     P=0.262N     P=0.284N    |P=0.583N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/53 (0%)    0/50 (0%)    0/50 (0%)    0/46 (0%)   |1/58 (2%)    4/58 (7%)    3/53 (6%)    0/53 (0%)    | 
|POLY-3 RATE (b)    |     0/51.28      0/41.29      0/19.25      0/6.89      |1/55.19      4/53.17      3/50.48      0/35.53      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |1.8%         7.5%         5.9%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    0/29 (0%)    0/0 (0%)     0/0 (0%)    |1/51 (2%)    4/46 (9%)    2/42 (5%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.421      P=0.151      P=0.251      P=0.925N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.449N     P=0.169      P=0.274      P=0.585N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.361N     P=0.173      P=0.276      P=0.554N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.538      P=0.164      P=0.269      P=0.628N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.587      P=0.151      P=0.271      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.266N     P=0.182      P=0.276      P=0.523N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/53 (0%)    0/50 (0%)    0/50 (0%)    1/46 (2%)   |1/58 (2%)    1/58 (2%)    2/53 (4%)    0/53 (0%)    | 
|POLY-3 RATE (b)    |     0/51.28      0/41.29      0/19.25      1/7.80      |1/55.19      1/53.17      2/50.37      0/35.53      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         12.8%       |1.8%         1.9%         4.0%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    0/29 (0%)    0/0 (0%)     0/0 (0%)    |1/51 (2%)    1/46 (2%)    2/42 (5%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          326         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.188      (e)          (e)          P=0.486     |P=0.534      P=0.738      P=0.432      P=0.925N     | 
|POLY 3             |     P=0.404      (e)          (e)          P=0.267     |P=0.514N     P=0.752      P=0.468      P=0.585N     | 
|POLY 1.5           |     P=0.182      (e)          (e)          P=0.327     |P=0.460N     P=0.755      P=0.470      P=0.554N     | 
|POLY 6             |     P=0.775      (e)          (e)          P=0.237     |P=0.578      P=0.748      P=0.462      P=0.628N     | 
|LOGISTIC REGRESSION|     P=0.881      (e)          (e)          (e)         |P=0.534      P=0.738      P=0.432      (e)          | 
|COCH-ARM / FISHERS |     P=0.182      (e)          (e)          P=0.465     |P=0.395N     P=0.752N     P=0.466      P=0.523N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/60 (47%)  27/59 (46%)  16/59 (27%)  1/60 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     28/57.40     27/53.68     16/31.46     1/9.95      |                                                    | 
|POLY-3 PERCENT (g) |     48.8%        50.3%        50.9%        10.1%       |                                                    | 
|TERMINAL (d)       |     26/52 (50%)  16/34 (47%)  0/0 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     637          460          451          414         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.082      P<0.001 **   P=0.189     |                                                    | 
|POLY 3             |     P=0.385N     P=0.512      P=0.513      P=0.119N    |                                                    | 
|POLY 1.5           |     P=0.003N**   P=0.559      P=0.237N     P<0.001N**  |                                                    | 
|POLY 6             |     P=0.125      P=0.452      P=0.091      P=0.545N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.192N     P=0.526      P=0.103      P=0.916     |                                                    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.534N     P=0.021N*    P<0.001N**  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    5/59 (8%)    1/59 (2%)    0/60 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/56.99      5/49.73      1/23.64      0/9.13      |                                                    | 
|POLY-3 PERCENT (g) |     1.8%         10.1%        4.2%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/52 (2%)    2/34 (6%)    0/0 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     729 (T)      641          517          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.036 *    P=0.045 *    P=0.417      P=1.000N    |                                                    | 
|POLY 3             |     P=0.196      P=0.075      P=0.545      P=0.721N    |                                                    | 
|POLY 1.5           |     P=0.583N     P=0.085      P=0.647      P=0.654N    |                                                    | 
|POLY 6             |     P=0.029 *    P=0.064      P=0.421      P=0.754N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.435      P=0.077      P=0.867      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.135N     P=0.100      P=0.748      P=0.500N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/59 (2%)    7/57 (12%)   4/58 (7%)   |                                                    | 
|POLY-3 RATE (b)    |     0/56.99      1/48.73      7/25.95      4/12.11     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         27.0%        33.0%       |                                                    | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      410          403         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.415      P<0.001 **   P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.469      P<0.001 **   P=0.005 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.481      P<0.001 **   P=0.011 *   |                                                    | 
|POLY 6             |     P<0.001 **   P=0.454      P<0.001 **   P=0.004 **  |                                                    | 
|LOGISTIC REGRESSION|     P=0.281      P=0.415      P=0.085      P=0.376     |                                                    | 
|COCH-ARM / FISHERS |     P=0.032 *    P=0.496      P=0.005 **   P=0.055     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    1/60 (2%)    1/60 (2%)    0/60 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/56.99      1/49.66      1/24.29      0/9.13      |                                                    | 
|POLY-3 PERCENT (g) |     3.5%         2.0%         4.1%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/52 (4%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     729 (T)      728          419          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.593      P=0.642N     P=0.490      P=1.000N    |                                                    | 
|POLY 3             |     P=0.555N     P=0.548N     P=0.667      P=0.602N    |                                                    | 
|POLY 1.5           |     P=0.338N     P=0.527N     P=0.645N     P=0.463N    |                                                    | 
|POLY 6             |     P=0.690N     P=0.573N     P=0.504      P=0.679N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.407N     P=0.627N     P=0.569N     (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.153N     P=0.500N     P=0.500N     P=0.248N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/6 (0%)     2/35 (6%)    2/47 (4%)   |0/2 (0%)     0/3 (0%)     0/3 (0%)     0/18 (0%)    | 
|POLY-3 RATE (b)    |     0/1.00       0/4.38       2/16.35      2/8.91      |0/1.98       0/2.44       0/2.14       0/12.26      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         12.2%        22.4%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/1 (0%)     0/2 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          556          376         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.011 *    P=0.139     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.328      (e)          P=0.959      P=0.940     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.400      (e)          P=0.968      P=0.981     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.371      (e)          P=0.917      P=0.534     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.608      (e)          P=0.862      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.652      (e)          P=0.944      P=0.958     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Artery, Subcutaneous Tissue                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/57.46      0/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     592          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.536N     P=0.308N     P=0.921N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.155N     P=0.272N     P=0.458N     P=0.603N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.118N     P=0.257N     P=0.352N     P=0.464N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.203N     P=0.291N     P=0.587N     P=0.679N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.120N     P=0.204N     P=0.301N     P=0.826N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.248N     P=0.248N     P=0.248N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    3/60 (5%)    14/60 (23%)  22/60 (37%) |0/60 (0%)    1/60 (2%)    2/60 (3%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     0/56.99      3/50.60      14/31.58     22/27.65    |0/56.31      1/54.26      2/57.29      4/41.32      | 
|POLY-3 PERCENT (g) |     0.0%         5.9%         44.3%        79.6%       |0.0%         1.8%         3.5%         9.7%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          542          451          277         |---          660          701          548          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.088      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.485      P=0.223      P=0.022 *    | 
|POLY 3             |     P<0.001 **   P=0.100      P<0.001 **   P<0.001 **  |P=0.010 *    P=0.493      P=0.242      P=0.032 *    | 
|POLY 1.5           |     P<0.001 **   P=0.108      P<0.001 **   P<0.001 **  |P=0.014 *    P=0.495      P=0.242      P=0.044 *    | 
|POLY 6             |     P<0.001 **   P=0.091      P<0.001 **   P<0.001 **  |P=0.007 **   P=0.489      P=0.238      P=0.019 *    | 
|LOGISTIC REGRESSION|     P=0.006 **   P=0.156      P=0.002 **   P=0.046 *   |P=0.042 *    P=0.512      P=0.240      P=0.106      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.122      P<0.001 **   P<0.001 **  |P=0.022 *    P=0.500      P=0.248      P=0.059      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)   |1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      1/24.01      2/10.80     |1/57.02      0/54.01      0/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.2%         18.5%       |1.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          566          391         |483          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   (e)          P=0.254      P=0.093     |P=0.308N     P=0.503N     P=0.493N     P=0.507N     | 
|POLY 3             |     P=0.073      (e)          P=0.352      P=0.077     |P=0.247N     P=0.511N     P=0.499N     P=0.570N     | 
|POLY 1.5           |     P=0.034 *    (e)          P=0.414      P=0.112     |P=0.278N     P=0.507N     P=0.498N     P=0.537N     | 
|POLY 6             |     P=0.311      (e)          P=0.288      P=0.063     |P=0.234N     P=0.516N     P=0.503N     P=0.618N     | 
|LOGISTIC REGRESSION|     P=0.341      (e)          P=0.663      P=0.787     |P=0.297N     P=0.432N     P=0.802N     P=0.447N     | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.248     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    1/60 (2%)    2/60 (3%)   |2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/49.70      1/24.29      2/10.79     |2/57.02      0/54.01      0/57.18      1/39.84      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         4.1%         18.5%       |3.5%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          717          419          392         |483          ---          ---          710          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.428      P=0.490      P=0.057     |P=0.675      P=0.255N     P=0.247N     P=0.628      | 
|POLY 3             |     P=0.061      P=0.473      P=0.353      P=0.077     |P=0.412N     P=0.250N     P=0.237N     P=0.620N     | 
|POLY 1.5           |     P=0.056      P=0.485      P=0.416      P=0.112     |P=0.441N     P=0.246N     P=0.236N     P=0.564N     | 
|POLY 6             |     P=0.145      P=0.458      P=0.289      P=0.063     |P=0.375N     P=0.255N     P=0.241N     P=0.699N     | 
|LOGISTIC REGRESSION|     P=0.517      P=0.461      P=0.783      P=0.777     |P=0.393N     P=0.204N     P=0.334N     P=0.426N     | 
|COCH-ARM / FISHERS |     P=0.153      P=0.500      P=0.500      P=0.248     |P=0.461N     P=0.248N     P=0.248N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    0/57 (0%)    2/58 (3%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/22.92      0/9.13      |0/55.32      0/53.12      2/55.37      0/37.66      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         3.6%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.265      (e)          P=0.217      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.370      (e)          P=0.238      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.477      (e)          P=0.238      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.246      (e)          P=0.235      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.217      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.590      (e)          P=0.244      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    7/60 (12%)   2/58 (3%)    0/60 (0%)   |0/59 (0%)    0/57 (0%)    0/58 (0%)    1/57 (2%)    | 
|POLY-3 RATE (b)    |     1/57.46      7/54.11      2/24.17      0/9.13      |0/55.32      0/53.12      0/55.37      1/38.44      | 
|POLY-3 PERCENT (g) |     1.7%         12.9%        8.3%         0.0%        |0.0%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     592          460          492          ---         |---          ---          ---          444          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.178      P=0.029 *    P=0.178      P=1.000N    |P=0.199      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.071      P=0.025 *    P=0.251      P=0.722N    |P=0.161      (e)          (e)          P=0.429      | 
|POLY 1.5           |     P=0.463      P=0.028 *    P=0.346      P=0.654N    |P=0.176      (e)          (e)          P=0.460      | 
|POLY 6             |     P=0.005 **   P=0.022 *    P=0.164      P=0.754N    |P=0.173      (e)          (e)          P=0.383      | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.179      P=0.748N     P=0.816N    |P=0.211      (e)          (e)          P=0.508      | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.031 *    P=0.487      P=0.500N    |P=0.196      (e)          (e)          P=0.491      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/60 (22%)  24/60 (40%)  49/58 (84%)  60/60 (100%)|11/59 (19%)  19/57 (33%)  21/58 (36%)  54/57 (95%)  | 
|POLY-3 RATE (b)    |     13/57.88     24/53.66     49/51.53     60/60.00    |11/56.65     19/55.13     21/57.18     54/54.87     | 
|POLY-3 PERCENT (g) |     22.5%        44.7%        95.1%        100.0%      |19.4%        34.5%        36.7%        98.4%        | 
|TERMINAL (d)       |     10/52 (19%)  11/34 (32%)  0/0 (0%)     0/0 (0%)    |8/52 (15%)   14/46 (30%)  15/47 (32%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     596          451          365          277         |483          497          553          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.044 *    P=0.025 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.056      P=0.031 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.056      P=0.030 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.054      P=0.030 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.026 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.054      P=0.019 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.024 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.055      P=0.027 *    P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    3/60 (5%)    0/58 (0%)    0/60 (0%)   |8/59 (14%)   5/57 (9%)    4/58 (7%)    2/57 (4%)    | 
|POLY-3 RATE (b)    |     2/56.99      3/49.65      0/22.92      0/9.13      |8/55.40      5/53.12      4/55.37      2/37.66      | 
|POLY-3 PERCENT (g) |     3.5%         6.0%         0.0%         0.0%        |14.4%        9.4%         7.2%         5.3%         | 
|TERMINAL (d)       |     2/52 (4%)    3/34 (9%)    0/0 (0%)     0/0 (0%)    |7/52 (14%)   5/46 (11%)   4/47 (9%)    2/5 (40%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |710          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491      P=0.312      P=1.000N     P=1.000N    |P=0.532      P=0.361N     P=0.234N     P=0.254      | 
|POLY 3             |     P=0.589N     P=0.438      P=0.461N     P=0.602N    |P=0.085N     P=0.306N     P=0.180N     P=0.152N     | 
|POLY 1.5           |     P=0.252N     P=0.465      P=0.358N     P=0.463N    |P=0.061N     P=0.301N     P=0.180N     P=0.095N     | 
|POLY 6             |     P=0.461      P=0.405      P=0.588N     P=0.679N    |P=0.131N     P=0.316N     P=0.187N     P=0.284N     | 
|LOGISTIC REGRESSION|     P=0.491      P=0.312      (e)          (e)         |P=0.535N     P=0.328N     P=0.205N     P=0.490      | 
|COCH-ARM / FISHERS |     P=0.075N     P=0.500      P=0.256N     P=0.248N    |P=0.038N*    P=0.302N     P=0.189N     P=0.053N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    3/58 (5%)    1/60 (2%)   |1/60 (2%)    2/58 (3%)    1/58 (2%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/50.39      3/24.43      1/10.06     |1/56.85      2/53.22      1/55.63      0/38.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         12.3%        9.9%        |1.8%         3.8%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          469          492          297         |562          729 (T)      661          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.493      P=0.019 *    P=0.497     |P=0.457N     P=0.468      P=0.753N     P=0.522N     | 
|POLY 3             |     P=0.031 *    P=0.475      P=0.036 *    P=0.281     |P=0.331N     P=0.477      P=0.756      P=0.573N     | 
|POLY 1.5           |     P=0.068      P=0.486      P=0.059      P=0.349     |P=0.295N     P=0.482      P=0.756      P=0.540N     | 
|POLY 6             |     P=0.063      P=0.462      P=0.022 *    P=0.246     |P=0.413N     P=0.470      P=0.752      P=0.621N     | 
|LOGISTIC REGRESSION|     P=0.324N     P=0.487      P=0.267      P=0.734     |P=0.209N     P=0.494      P=0.665      P=0.418N     | 
|COCH-ARM / FISHERS |     P=0.351      P=0.500      P=0.116      P=0.500     |P=0.251N     P=0.487      P=0.744      P=0.504N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    3/58 (5%)    1/60 (2%)   |1/60 (2%)    1/58 (2%)    1/58 (2%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      1/49.65      3/24.55      1/10.06     |1/56.85      1/53.22      1/55.59      0/38.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.0%         12.2%        9.9%        |1.8%         1.9%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          729 (T)      470          302         |562          729 (T)      673          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.415      P=0.023 *    P=0.493     |P=0.480N     P=0.743      P=0.758N     P=0.522N     | 
|POLY 3             |     P=0.031 *    P=0.473      P=0.036 *    P=0.281     |P=0.380N     P=0.746      P=0.755      P=0.573N     | 
|POLY 1.5           |     P=0.068      P=0.484      P=0.060      P=0.349     |P=0.352N     P=0.749      P=0.756      P=0.540N     | 
|POLY 6             |     P=0.060      P=0.458      P=0.022 *    P=0.246     |P=0.451N     P=0.741      P=0.752      P=0.621N     | 
|LOGISTIC REGRESSION|     P=0.666N     P=0.415      P=0.332      P=0.765     |P=0.258N     P=0.762      P=0.672      P=0.418N     | 
|COCH-ARM / FISHERS |     P=0.351      P=0.500      P=0.116      P=0.500     |P=0.315N     P=0.744      P=0.744      P=0.504N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    5/60 (8%)    6/58 (10%)   3/60 (5%)   |1/60 (2%)    4/58 (7%)    6/58 (10%)   1/59 (2%)    | 
|POLY-3 RATE (b)    |     2/56.99      5/50.71      6/26.13      3/11.83     |1/56.85      4/53.22      6/55.84      1/39.09      | 
|POLY-3 PERCENT (g) |     3.5%         9.9%         23.0%        25.4%       |1.8%         7.5%         10.7%        2.6%         | 
|TERMINAL (d)       |     2/52 (4%)    2/34 (6%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    4/46 (9%)    4/47 (9%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      469          497          297         |562          729 (T)      661          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.111      P<0.001 **   P=0.080     |P=0.101      P=0.152      P=0.056      P=0.608      | 
|POLY 3             |     P=0.007 **   P=0.173      P=0.016 *    P=0.098     |P=0.344      P=0.161      P=0.055      P=0.670      | 
|POLY 1.5           |     P=0.053      P=0.192      P=0.041 *    P=0.198     |P=0.489      P=0.165      P=0.055      P=0.713      | 
|POLY 6             |     P=0.003 **   P=0.152      P=0.005 **   P=0.061     |P=0.176      P=0.155      P=0.053      P=0.597      | 
|LOGISTIC REGRESSION|     P=0.585N     P=0.242      P=0.166      P=0.692N    |P=0.545      P=0.172      P=0.039 *    P=0.710N     | 
|COCH-ARM / FISHERS |     P=0.498      P=0.219      P=0.125      P=0.500     |P=0.505N     P=0.172      P=0.052      P=0.748      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/57 (0%)    0/54 (0%)    2/53 (4%)    0/55 (0%)   |1/58 (2%)    0/57 (0%)    0/57 (0%)    0/52 (0%)    | 
|POLY-3 RATE (b)    |     0/54.72      0/45.09      2/22.05      0/8.47      |1/55.73      0/53.12      0/54.48      0/34.63      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         9.1%         0.0%        |1.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          539          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          P=0.032 *    (e)         |P=0.473N     P=0.524N     P=0.520N     P=0.927N     | 
|POLY 3             |     P=0.163      (e)          P=0.105      (e)         |P=0.254N     P=0.510N     P=0.505N     P=0.591N     | 
|POLY 1.5           |     P=0.229      (e)          P=0.145      (e)         |P=0.287N     P=0.507N     P=0.503N     P=0.559N     | 
|POLY 6             |     P=0.307      (e)          P=0.075      (e)         |P=0.242N     P=0.514N     P=0.508N     P=0.636N     | 
|LOGISTIC REGRESSION|     P=0.738      (e)          P=0.340      (e)         |P=0.473N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.589      (e)          P=0.230      (e)         |P=0.317N     P=0.504N     P=0.504N     P=0.527N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/57 (0%)    1/54 (2%)    0/53 (0%)    1/55 (2%)   |0/58 (0%)    0/57 (0%)    0/57 (0%)    2/52 (4%)    | 
|POLY-3 RATE (b)    |     0/54.72      1/45.72      0/20.99      1/9.27      |0/55.73      0/53.12      0/54.48      2/35.27      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         10.8%       |0.0%         0.0%         0.0%         5.7%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          526          ---          422         |---          ---          ---          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    P=0.486      (e)          P=0.100     |P=0.012 *    (e)          (e)          P=0.093      | 
|POLY 3             |     P=0.272      P=0.464      (e)          P=0.277     |P=0.033 *    (e)          (e)          P=0.152      | 
|POLY 1.5           |     P=0.250      P=0.475      (e)          P=0.343     |P=0.034 *    (e)          (e)          P=0.178      | 
|POLY 6             |     P=0.358      P=0.451      (e)          P=0.244     |P=0.042 *    (e)          (e)          P=0.120      | 
|LOGISTIC REGRESSION|     P=0.718N     P=0.517      (e)          P=0.922     |P=0.078      (e)          (e)          P=0.274      | 
|COCH-ARM / FISHERS |     P=0.400      P=0.486      (e)          P=0.491     |P=0.039 *    (e)          (e)          P=0.221      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/57 (0%)    0/54 (0%)    0/53 (0%)    0/55 (0%)   |0/58 (0%)    1/57 (2%)    2/57 (4%)    1/52 (2%)    | 
|POLY-3 RATE (b)    |     0/54.72      0/45.09      0/20.99      0/8.47      |0/55.73      1/53.14      2/54.75      1/35.12      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         1.9%         3.7%         2.9%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          723          673          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.113      P=0.476      P=0.227      P=0.461      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.192      P=0.491      P=0.234      P=0.411      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.253      P=0.493      P=0.235      P=0.442      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.134      P=0.487      P=0.230      P=0.367      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.401      P=0.489      P=0.219      P=0.592      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.335      P=0.496      P=0.243      P=0.473      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/57 (0%)    0/54 (0%)    0/53 (0%)    0/55 (0%)   |0/58 (0%)    0/57 (0%)    2/57 (4%)    0/52 (0%)    | 
|POLY-3 RATE (b)    |     0/54.72      0/45.09      0/20.99      0/8.47      |0/55.73      0/53.12      2/54.86      0/34.63      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         3.7%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          624          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.403      (e)          P=0.234      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.349      (e)          P=0.234      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.456      (e)          P=0.235      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.235      (e)          P=0.231      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.620      (e)          P=0.201      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.574      (e)          P=0.243      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/57 (0%)    3/52 (6%)    3/45 (7%)    6/54 (11%)  |1/57 (2%)    0/56 (0%)    0/55 (0%)    1/44 (2%)    | 
|POLY-3 RATE (b)    |     0/54.72      3/44.32      3/19.41      6/13.03     |1/54.56      0/50.95      0/53.44      1/30.20      | 
|POLY-3 PERCENT (g) |     0.0%         6.8%         15.5%        46.0%       |1.8%         0.0%         0.0%         3.3%         | 
|TERMINAL (d)       |     0/51 (0%)    0/29 (0%)    0/0 (0%)     0/0 (0%)    |0/50 (0%)    0/44 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          469          410          368         |562          ---          ---          610          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.113      P=0.025 *    P<0.001 **  |P=0.552      P=0.507N     P=0.493N     P=0.704      | 
|POLY 3             |     P<0.001 **   P=0.086      P=0.024 *    P<0.001 **  |P=0.522      P=0.514N     P=0.504N     P=0.618      | 
|POLY 1.5           |     P<0.001 **   P=0.093      P=0.040 *    P<0.001 **  |P=0.531      P=0.510N     P=0.504N     P=0.658      | 
|POLY 6             |     P<0.001 **   P=0.077      P=0.015 *    P<0.001 **  |P=0.550      P=0.518N     P=0.506N     P=0.557      | 
|LOGISTIC REGRESSION|     P=0.477N     P=0.138      P=0.315      P=0.429     |P=0.609      P=0.458N     P=0.692N     P=0.726N     | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.105      P=0.083      P=0.011 *   |P=0.545      P=0.504N     P=0.509N     P=0.684      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/57 (7%)    3/52 (6%)    1/45 (2%)    0/54 (0%)   |1/57 (2%)    0/56 (0%)    0/55 (0%)    0/44 (0%)    | 
|POLY-3 RATE (b)    |     4/54.72      3/42.49      1/18.06      0/7.95      |1/54.02      0/50.95      0/53.44      0/29.79      | 
|POLY-3 PERCENT (g) |     7.3%         7.1%         5.5%         0.0%        |1.9%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/51 (8%)    1/29 (3%)    0/0 (0%)     0/0 (0%)    |1/50 (2%)    0/44 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      690          556          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.343      P=0.547      P=0.321      P=1.000N    |P=0.467N     P=0.525N     P=0.512N     P=0.923N     | 
|POLY 3             |     P=0.480N     P=0.634N     P=0.589N     P=0.498N    |P=0.263N     P=0.512N     P=0.502N     P=0.613N     | 
|POLY 1.5           |     P=0.189N     P=0.598N     P=0.439N     P=0.292N    |P=0.298N     P=0.509N     P=0.503N     P=0.585N     | 
|POLY 6             |     P=0.605      P=0.626      P=0.561      P=0.622N    |P=0.243N     P=0.515N     P=0.504N     P=0.652N     | 
|LOGISTIC REGRESSION|     P=0.741      P=0.617      P=0.851      (e)         |P=0.467N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.033N*    P=0.552N     P=0.264N     P=0.066N    |P=0.333N     P=0.504N     P=0.509N     P=0.564N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/57 (2%)    0/52 (0%)    0/45 (0%)    0/54 (0%)   |5/57 (9%)    0/56 (0%)    2/55 (4%)    1/44 (2%)    | 
|POLY-3 RATE (b)    |     1/54.72      0/42.29      0/17.51      0/7.95      |5/54.09      0/50.95      2/53.44      1/29.87      | 
|POLY-3 PERCENT (g) |     1.8%         0.0%         0.0%         0.0%        |9.2%         0.0%         3.7%         3.4%         | 
|TERMINAL (d)       |     1/51 (2%)    0/29 (0%)    0/0 (0%)     0/0 (0%)    |4/50 (8%)    0/44 (0%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |710          ---          729 (T)      710          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.908N     P=0.613N     P=1.000N     P=1.000N    |P=0.535N     P=0.047N*    P=0.248N     P=0.577      | 
|POLY 3             |     P=0.431N     P=0.551N     P=0.685N     P=0.728N    |P=0.177N     P=0.037N*    P=0.223N     P=0.297N     | 
|POLY 1.5           |     P=0.322N     P=0.537N     P=0.630N     P=0.664N    |P=0.171N     P=0.035N*    P=0.224N     P=0.234N     | 
|POLY 6             |     P=0.555N     P=0.568N     P=0.737N     P=0.758N    |P=0.187N     P=0.039N*    P=0.226N     P=0.404N     | 
|LOGISTIC REGRESSION|     P=0.908N     (e)          (e)          (e)         |P=0.362N     P=0.040N*    P=0.227N     P=0.643N     | 
|COCH-ARM / FISHERS |     P=0.317N     P=0.523N     P=0.559N     P=0.514N    |P=0.161N     P=0.030N*    P=0.234N     P=0.174N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/59 (17%)  11/59 (19%)  3/59 (5%)    0/59 (0%)   |14/60 (23%)  16/59 (27%)  16/58 (28%)  13/53 (25%)  | 
|POLY-3 RATE (b)    |     10/56.49     11/50.78     3/24.59      0/9.00      |14/56.77     16/53.03     16/56.04     13/37.85     | 
|POLY-3 PERCENT (g) |     17.7%        21.7%        12.2%        0.0%        |24.7%        30.2%        28.6%        34.3%        | 
|TERMINAL (d)       |     9/52 (17%)   6/33 (18%)   0/0 (0%)     0/0 (0%)    |13/52 (25%)  15/45 (33%)  12/46 (26%)  2/5 (40%)    | 
|FIRST INCIDENCE    |     596          485          548          ---         |592          723          624          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    P=0.179      P=0.007 **   P=1.000N    |P<0.001 **   P=0.255      P=0.300      P<0.001 **   | 
|POLY 3             |     P=0.413N     P=0.393      P=0.401N     P=0.312N    |P=0.212      P=0.333      P=0.400      P=0.218      | 
|POLY 1.5           |     P=0.040N*    P=0.439      P=0.172N     P=0.068N    |P=0.334      P=0.356      P=0.398      P=0.352      | 
|POLY 6             |     P=0.286      P=0.338      P=0.479      P=0.548N    |P=0.099      P=0.304      P=0.388      P=0.085      | 
|LOGISTIC REGRESSION|     P=0.163N     P=0.510      P=0.682N     P=0.873N    |P=0.074      P=0.319      P=0.391      P=0.087      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500      P=0.037N*    P<0.001N**  |P=0.511      P=0.396      P=0.375      P=0.528      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    0/59 (0%)    0/59 (0%)    0/59 (0%)   |2/60 (3%)    1/59 (2%)    0/58 (0%)    0/53 (0%)    | 
|POLY-3 RATE (b)    |     0/56.04      0/48.65      0/23.02      0/9.00      |2/57.02      1/53.01      0/55.26      0/35.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |3.5%         1.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/33 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    1/45 (2%)    0/46 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |483          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.178N     P=0.535N     P=0.249N     P=0.445N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.525N     P=0.245N     P=0.353N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.518N     P=0.243N     P=0.311N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.534N     P=0.249N     P=0.423N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.091N     P=0.477N     P=0.341N     P=0.182N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.112N     P=0.506N     P=0.256N     P=0.280N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    0/59 (0%)    0/59 (0%)    0/59 (0%)   |0/60 (0%)    1/59 (2%)    0/58 (0%)    2/53 (4%)    | 
|POLY-3 RATE (b)    |     0/56.04      0/48.65      0/23.02      0/9.00      |0/56.31      1/53.01      0/55.26      2/36.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         1.9%         0.0%         5.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/33 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/45 (2%)    0/46 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          610          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.032 *    P=0.471      (e)          P=0.129      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.095      P=0.488      (e)          P=0.153      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.104      P=0.491      (e)          P=0.178      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.098      P=0.484      (e)          P=0.122      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.141      P=0.471      (e)          P=0.254      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.119      P=0.496      (e)          P=0.218      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/14 (36%)   0/9 (0%)     0/2 (0%)     0/0 (0%)    |0/8 (0%)     0/4 (0%)     0/0 (0%)     0/2 (0%)     | 
|POLY-3 RATE (b)    |     5/13.46      0/8.83       0/0.81       0/0.00      |0/8.00       0/4.00       0/0.00       0/1.86       | 
|POLY-3 PERCENT (g) |     37.2%        0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/12 (42%)   0/8 (0%)     0/0 (0%)     0/0 (0%)    |0/8 (0%)     0/4 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152N     P=0.062N     P=1.000N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          P=0.051N     P=0.632N     (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          P=0.053N     P=0.550N     (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          P=0.049N*    P=0.714N     (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.152N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.106N     P=0.059N     P=0.458N     P=1.000     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 51      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/14 (71%)  9/9 (100%)   1/2 (50%)    0/0 (0%)    |8/8 (100%)   4/4 (100%)   0/0 (0%)     2/2 (100%)   | 
|POLY-3 RATE (b)    |     10/14.00     9/9.00       1/1.27       0/0.00      |8/8.00       4/4.00       0/0.00       2/2.00       | 
|POLY-3 PERCENT (g) |     71.4%        100.0%       79.0%        0.0%        |100.0%       100.0%       0.0%         100.0%       | 
|TERMINAL (d)       |     8/12 (67%)   8/8 (100%)   0/0 (0%)     0/0 (0%)    |8/8 (100%)   4/4 (100%)   0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     592          686          596          ---         |729 (T)      729 (T)      ---          702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.097      P=0.249      P=0.118      P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          P=0.109      P=0.749      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          P=0.109      P=0.753N     (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          P=0.109      P=0.678      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.356      (e)          P=0.903N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.623      P=0.113      P=0.542N     P=1.000     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urethra                                                                                                                          | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     1/1 (100%)   2/2 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       1/1.00       2/2.00      |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         100.0%       100.0%      |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          522          368         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 52      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/60 (2%)    0/59 (0%)    2/60 (3%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/56.31      0/53.96      2/57.40      1/39.06      | 
|POLY-3 PERCENT (g) |                                                        |1.8%         0.0%         3.5%         2.6%         | 
|TERMINAL (d)       |                                                        |1/52 (2%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          673          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.138      P=0.524N     P=0.475      P=0.300      | 
|POLY 3             |                                                        |P=0.353      P=0.509N     P=0.507      P=0.672      | 
|POLY 1.5           |                                                        |P=0.419      P=0.506N     P=0.507      P=0.715      | 
|POLY 6             |                                                        |P=0.287      P=0.512N     P=0.502      P=0.600      | 
|LOGISTIC REGRESSION|                                                        |P=0.383      (e)          P=0.499      P=0.577      | 
|COCH-ARM / FISHERS |                                                        |P=0.497      P=0.504N     P=0.500      P=0.748      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/60 (2%)    1/59 (2%)    3/60 (5%)    0/59 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/56.31      1/53.96      3/57.18      0/38.93      | 
|POLY-3 PERCENT (g) |                                                        |1.8%         1.9%         5.3%         0.0%         | 
|TERMINAL (d)       |                                                        |1/52 (2%)    1/46 (2%)    3/47 (6%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.379      P=0.734      P=0.271      P=0.927N     | 
|POLY 3             |                                                        |P=0.573N     P=0.751      P=0.312      P=0.571N     | 
|POLY 1.5           |                                                        |P=0.498N     P=0.754      P=0.312      P=0.539N     | 
|POLY 6             |                                                        |P=0.463      P=0.747      P=0.306      P=0.619N     | 
|LOGISTIC REGRESSION|                                                        |P=0.379      P=0.734      P=0.271      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.413N     P=0.748      P=0.309      P=0.504N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 53      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |24/60 (40%)  24/59 (41%)  22/60 (37%)  15/59 (25%)  | 
|POLY-3 RATE (b)    |                                                        |24/56.46     24/54.03     22/57.56     15/42.49     | 
|POLY-3 PERCENT (g) |                                                        |42.5%        44.4%        38.2%        35.3%        | 
|TERMINAL (d)       |                                                        |22/52 (42%)  23/46 (50%)  19/47 (40%)  4/5 (80%)    | 
|FIRST INCIDENCE    |                                                        |710          712          690          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   P=0.358      P=0.554      P<0.001 **   | 
|POLY 3             |                                                        |P=0.218N     P=0.496      P=0.392N     P=0.301N     | 
|POLY 1.5           |                                                        |P=0.109N     P=0.519      P=0.393N     P=0.158N     | 
|POLY 6             |                                                        |P=0.441N     P=0.458      P=0.412N     P=0.569      | 
|LOGISTIC REGRESSION|                                                        |P=0.369      P=0.398      P=0.462N     P=0.505      | 
|COCH-ARM / FISHERS |                                                        |P=0.039N*    P=0.544      P=0.426N     P=0.067N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/60 (3%)    1/59 (2%)    1/60 (2%)    2/59 (3%)    | 
|POLY-3 RATE (b)    |                                                        |2/56.85      1/53.98      1/57.29      2/39.89      | 
|POLY-3 PERCENT (g) |                                                        |3.5%         1.9%         1.8%         5.0%         | 
|TERMINAL (d)       |                                                        |1/52 (2%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |562          723          701          583          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.282      P=0.532N     P=0.514N     P=0.471      | 
|POLY 3             |                                                        |P=0.463      P=0.518N     P=0.497N     P=0.560      | 
|POLY 1.5           |                                                        |P=0.501      P=0.513N     P=0.496N     P=0.622      | 
|POLY 6             |                                                        |P=0.439      P=0.526N     P=0.504N     P=0.460      | 
|LOGISTIC REGRESSION|                                                        |P=0.554N     P=0.499N     P=0.570N     P=0.580N     | 
|COCH-ARM / FISHERS |                                                        |P=0.551      P=0.506N     P=0.500N     P=0.684      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 54      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   O-NITROTOLUENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |54/60 (90%)  51/59 (86%)  53/60 (88%)  37/59 (63%)  | 
|POLY-3 RATE (b)    |                                                        |54/56.94     51/55.39     53/59.01     37/49.73     | 
|POLY-3 PERCENT (g) |                                                        |94.8%        92.1%        89.8%        74.4%        | 
|TERMINAL (d)       |                                                        |50/52 (96%)  45/46 (98%)  46/47 (98%)  5/5 (100%)   | 
|FIRST INCIDENCE    |                                                        |592          553          553          403          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   P=0.270      P=0.208      P<0.001 **   | 
|POLY 3             |                                                        |P<0.001N**   P=0.407N     P=0.236N     P<0.001N**   | 
|POLY 1.5           |                                                        |P<0.001N**   P=0.378N     P=0.301N     P<0.001N**   | 
|POLY 6             |                                                        |P=0.003N**   P=0.482N     P=0.230N     P=0.006N**   | 
|LOGISTIC REGRESSION|                                                        |P=0.076N     P=0.483N     P=0.255N     P=0.058N     | 
|COCH-ARM / FISHERS |                                                        |P<0.001N**   P=0.376N     P=0.500N     P<0.001N**   | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).