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TDMS Study 05205-07 Pathology Tables

NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                             P-NITROTOLUENE                                            DATE: 03/13/00    
EXPERIMENT: 05205 TEST: 07                                                                                        TIME: 13:54:43    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C62537D     
CONT: N01-ES-55393                                                                                                CAS: 99-99-0      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39

LAB: SOUTHERN RESEARCH INSTITUTE                      P-NITROTOLUENE                                              DATE: 03/13/00


EXPERIMENT: 05205 TEST: 07                                                                                        TIME: 14:15:45



TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  62537D

CONT: N01-ES-55393                                                                                                CAS: 99-99-0
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
                                               CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE

==================================================================================================================================
        0       PPM                 1250    PPM                        2500    PPM                        5000    PPM
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------
                                          DOSE/                              DOSE/                              DOSE/
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==================================================================================================================================
  4    19.4   205.9      18.9    200.4    0.97      118     18.6    196.4    0.96      236     18.8    180.6    0.97      521
  8    18.1   281.5      18.1    273.1    1.00       83     17.8    269.6    0.98      165     17.9    246.1    0.99      363
 12    17.4   324.0      17.0    318.8    0.98       67     17.5    309.9    1.01      141     17.4    282.5    1.00      308
 16    18.4   352.2      17.8    342.0    0.97       65     18.1    336.4    0.98      135     18.0    303.4    0.98      297
 20    17.1   377.2      16.8    364.8    0.98       58     16.8    359.1    0.98      117     16.3    321.5    0.95      254
 24    17.8   390.4      17.0    380.8    0.96       56     16.8    368.3    0.94      114     16.0    334.7    0.90      239
 28    17.5   404.5      16.9    391.9    0.97       54     17.1    384.4    0.98      111     16.5    342.8    0.94      240
 32    16.5   421.3      16.1    404.3    0.98       50     17.0    393.6    1.03      108     16.4    352.4    0.99      233
 36    16.7   422.4      16.6    410.3    0.99       51     16.5    402.7    0.99      103     15.6    361.8    0.93      216
 40    17.0   425.7      16.7    413.7    0.98       51     16.3    405.1    0.96      100     15.9    361.3    0.94      220
 44    16.2   433.0      15.9    422.1    0.98       47     15.9    410.4    0.98       97     15.4    368.4    0.95      209
 48    15.9   436.0      15.2    425.8    0.96       45     15.3    417.9    0.96       92     14.1    370.1    0.89      191
 52    15.5   438.0      15.6    426.8    1.01       46     15.4    418.6    0.99       92     15.2    373.7    0.98      203
 56    17.4   434.9      16.6    423.4    0.95       49     16.6    415.0    0.95      100     15.5    373.3    0.89      208
 60    16.4   437.0      16.5    429.9    1.01       48     16.1    419.4    0.98       96     16.2    377.9    0.99      214
 64    16.6   439.5      16.1    431.5    0.97       47     16.0    424.5    0.96       94     14.9    381.0    0.90      196
 68    16.1   439.2      15.3    431.4    0.95       44     15.7    427.2    0.98       92     15.3    380.8    0.95      200
 72    16.0   437.5      15.6    427.9    0.98       46     16.1    424.5    1.01       95     16.2    384.9    1.01      211
 76    16.6   440.4      16.3    436.7    0.98       47     16.2    432.0    0.98       94     15.2    389.9    0.92      195
 80    15.9   443.8      15.9    436.5    1.00       45     15.5    432.6    0.97       89     15.2    389.6    0.96      196
 84    15.6   434.1      15.7    433.6    1.01       45     15.3    429.5    0.98       89     15.3    386.8    0.98      198
 88    15.3   431.5      15.0    428.0    0.98       44     14.6    423.7    0.95       86     14.4    384.7    0.94      187
 92    15.6   424.7      15.2    426.3    0.97       45     14.8    416.9    0.95       89     15.3    381.2    0.98      200
 96    16.2   419.4      15.9    419.5    0.98       47     15.5    412.1    0.96       94     15.6    379.9    0.96      205
100    13.7   410.4      15.3    415.4    1.12       46     14.1    408.9    1.03       86     14.6    373.7    1.07      195
104    14.5   402.1      14.6    409.0    1.01       44     14.0    402.0    0.97       87     13.8    366.0    0.95      189

1 TO 13 WEEKS 
----------------
MEAN   18.3   270.5      18.0    264.1    0.98       89     18.0    258.6    0.98      181     18.0    236.4    0.99      397
SD(D)   1.0               1.0             0.01       26      0.5             0.02       50      0.7             0.02      111
CV(E)   5.4               5.4             1.4      29.5      3.0             2.4      27.4      4.0             1.6      27.9

14 TO 52 WEEKS
----------------
MEAN   16.9   410.1      16.5    398.2    0.98       52     16.5    389.6    0.98      107     16.0    349.0    0.95      230
SD(D)   0.9               0.8             0.02        6      0.8             0.02       13      1.0             0.03       30
CV(E)   5.1               4.7             1.7      12.0      5.1             2.4      12.3      6.3             3.6      13.1

> 52 WEEKS    
----------------
MEAN   15.8   430.4      15.7    426.9    0.99       46     15.4    420.6    0.97       92     15.2    380.7    0.96      199
SD(D)   1.0               0.6             0.04        2      0.8             0.02        4      0.7             0.05        8
CV(E)   6.0               3.9             4.2       3.4      5.4             2.3       4.7      4.4             4.9       4.1
==================================================================================================================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
                                               CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE

==================================================================================================================================
        0       PPM                 1250    PPM                        2500    PPM                        5000    PPM
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------
                                           DOSE/                              DOSE/                              DOSE/
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==================================================================================================================================
  4    12.4   143.6      12.4    140.5     1.00     110     12.0    140.4     0.97     214     12.4    134.3     1.00     462
  8    11.5   167.9      11.6    165.6     1.01      88     11.5    163.7     1.00     176     11.5    155.5     1.00     370
 12    10.6   181.9      10.6    179.0     1.00      74     10.7    176.3     1.01     152     11.2    166.6     1.06     336
 16    11.5   192.3      11.1    187.7     0.97      74     11.3    184.9     0.98     153     11.3    173.2     0.98     327
 20    10.7   197.5      10.3    194.1     0.96      66     10.2    191.3     0.95     134     10.5    181.8     0.98     289
 24    10.1   203.9      10.4    200.4     1.03      65      9.8    196.3     0.97     125     10.2    184.6     1.01     276
 28    10.8   210.9      10.6    206.5     0.98      64     10.2    201.4     0.94     127     10.2    188.9     0.94     269
 32    10.6   219.6      10.0    208.7     0.94      60      9.8    206.2     0.92     118     10.3    193.6     0.97     266
 36    10.6   222.6      10.0    215.6     0.94      58     10.2    212.1     0.96     120      9.8    198.2     0.92     247
 40    10.9   224.2      10.5    215.7     0.96      61     10.1    212.8     0.93     119      9.8    195.6     0.90     252
 44    10.5   231.6       9.9    221.5     0.94      56      9.9    215.9     0.94     115      9.6    198.2     0.91     243
 48    10.1   234.0       9.6    224.4     0.95      53      9.0    217.6     0.89     103      8.4    197.9     0.83     211
 52    11.2   235.7      10.3    227.0     0.92      57     10.0    219.7     0.89     114      9.7    200.7     0.87     242
 56    11.4   243.4      10.9    231.0     0.96      59     10.6    224.5     0.93     118      9.9    200.7     0.87     248
 60    10.9   249.6      11.0    235.6     1.01      58     10.7    225.8     0.98     118     10.1    201.6     0.93     251
 64    11.5   257.9      11.0    239.4     0.96      57     10.5    231.9     0.91     113      9.8    202.8     0.85     242
 68    11.4   263.2      11.0    249.0     0.96      55     10.9    237.9     0.96     114      9.8    205.5     0.86     237
 72    12.1   270.3      11.3    253.0     0.93      56     10.8    241.0     0.89     112      9.9    207.0     0.82     240
 76    11.7   276.6      11.3    260.4     0.97      54     11.3    249.0     0.97     113      9.6    207.8     0.82     231
 80    12.2   284.6      11.5    267.4     0.94      54     11.4    257.4     0.93     110     10.0    212.7     0.82     236
 84    12.3   288.3      11.7    268.2     0.95      55     11.0    261.0     0.89     106     10.2    211.5     0.83     241
 88    12.0   293.1      11.0    268.6     0.92      51     10.9    261.6     0.91     104      9.9    210.2     0.83     235
 92    11.3   295.2      11.1    271.7     0.98      51     10.5    261.6     0.93     101     10.3    211.6     0.91     243
 96    12.8   293.1      11.9    269.2     0.93      55     11.6    261.8     0.91     111     10.2    210.8     0.80     241
100    11.6   293.0      11.8    272.1     1.02      54     11.6    266.2     1.00     109      9.5    211.9     0.82     225
104    11.7   293.8      11.2    271.5     0.96      51     11.4    267.2     0.97     107      9.6    209.8     0.82     230

1 TO 13 WEEKS 
----------------
MEAN   11.5   164.5      11.5    161.7     1.00      91     11.4    160.1     0.99     181     11.7    152.2     1.02     389
SD(D)   0.9               0.9              0.01      18      0.7              0.02      32      0.6              0.03      65
CV(E)   7.9               7.9              0.5     20.2      6.0              2.2     17.5      5.4              3.2     16.8

14 TO 52 WEEKS
----------------
MEAN   10.7   217.2      10.3    210.2     0.96      61     10.1    205.8     0.94     123     10.0    191.3     0.93     262
SD(D)   0.4               0.4              0.03       6      0.6              0.03      13      0.8              0.06      31
CV(E)   3.9               4.2              3.1      9.9      5.7              3.3     10.9      7.6              6.1     12.0

> 52 WEEKS    
----------------
MEAN   11.8   277.1      11.3    258.3     0.96      55     11.0    249.7     0.94     110      9.9    208.0     0.84     238
SD(D)   0.5               0.4              0.03       3      0.4              0.04       5      0.2              0.04       7
CV(E)   4.2               3.1              3.0      4.7      3.6              3.7      4.7      2.4              4.6      3.0
==================================================================================================================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
                                 DIAGNOSTIC TRAILER REPORT
                                 FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
                                 CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE
=========================================================================================================
        0       PPM              1250    PPM              2500    PPM              5000    PPM
     ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS
==========================================================================================================
  B              102.4  50                102.2  50                102.8  50                101.2  50
  1              102.4  50                102.2  50                102.8  50                101.2  50
  4  19.4  7965  205.9  50    18.9  7914  200.4  50    18.6  7871  196.4  50    18.8  7724  180.6  50
  8  18.1  7778  281.5  50    18.1  7889  273.1  50    17.8  7840  269.6  50    17.9  7708  246.1  50
 12  17.4  7342  324.0  50    17.0  8037  318.8  50    17.5  7873  309.9  50    17.4  7773  282.5  50
 16  18.4  7856  352.2  50    17.8  7719  342.0  50    18.1  7590  336.4  50    18.0  7531  303.4  50
 20  17.1  8262  377.2  50    16.8  8266  364.8  50    16.8  8245  359.1  50    16.3  8036  321.5  50
 24  17.8  5881  390.4  50    17.0  5726  380.8  50    16.8  5869  368.3  50    16.0  5863  334.7  50
 28  17.5  8077  404.5  50    16.9  7486  391.9  50    17.1  7923  384.4  50    16.5  7884  342.8  50
 32  16.5  8097  421.3  50    16.1  8085  404.3  50    17.0  8071  393.6  50    16.4  8049  352.4  50
 36  16.7  8080  422.4  50    16.6  8214  410.3  50    16.5  8189  402.7  50    15.6  8184  361.8  50
 40  17.0  8190  425.7  50    16.7  8137  413.7  50    16.3  8158  405.1  50    15.9  7915  361.3  50
 44  16.2  8227  433.0  50    15.9  8100  422.1  50    15.9  8085  410.4  50    15.4  8065  368.4  50
 48  15.9  8142  436.0  50    15.2  8069  425.8  50    15.3  8237  417.9  50    14.1  8250  370.1  50
 52  15.5  8264  438.0  50    15.6  8254  426.8  50    15.4  8246  418.6  50    15.2  8237  373.7  50
 56  17.4  7366  434.9  49    16.6  7847  423.4  50    16.6  8112  415.0  50    15.5  7964  373.3  50
 60  16.4  8038  437.0  49    16.5  8219  429.9  50    16.1  8038  419.4  50    16.2  8101  377.9  50
 64  16.6  7909  439.5  49    16.1  8272  431.5  50    16.0  7903  424.5  50    14.9  8147  381.0  50
 68  16.1  8097  439.2  49    15.3  8249  431.4  50    15.7  8239  427.2  50    15.3  8211  380.8  50
 72  16.0  8138  437.5  49    15.6  8101  427.9  49    16.1  8265  424.5  50    16.2  7836  384.9  48
 76  16.6  8092  440.4  48    16.3  7900  436.7  47    16.2  8232  432.0  49    15.2  8049  389.9  48
 80  15.9  7979  443.8  48    15.9  7788  436.5  47    15.5  8117  432.6  49    15.2  7926  389.6  48
 84  15.6  7812  434.1  48    15.7  7474  433.6  46    15.3  7933  429.5  49    15.3  7748  386.8  48
 88  15.3  7432  431.5  45    15.0  7093  428.0  44    14.6  8070  423.7  49    14.4  7365  384.7  46
 92  15.6  6718  424.7  43    15.2  6618  426.3  41    14.8  7382  416.9  47    15.3  7259  381.2  45
 96  16.2  6685  419.4  41    15.9  6397  419.5  40    15.5  7254  412.1  46    15.6  7315  379.9  45
100  13.7  5685  410.4  37    15.3  6472  415.4  39    14.1  6150  408.9  42    14.6  6473  373.7  41
104  14.5  5309  402.1  33    14.6  6245  409.0  39    14.0  6368  402.0  41    13.8  6487  366.0  40

MEAN BODY WGT FOR WEEKS
1 TO 13          228.5                    223.6                    219.7                    202.6
14 TO 52         410.1                    398.2                    389.6                    349.0
 > 52            430.4                    426.9                    420.6                    380.7
=========================================================================================================

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
                                 DIAGNOSTIC TRAILER REPORT
                                 FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
                                 CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE
=========================================================================================================
        0       PPM              1250    PPM              2500    PPM              5000    PPM
     ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS
==========================================================================================================
  B               91.4  50                 90.2  50                 91.3  50                 92.0  50
  1               91.4  50                 90.2  50                 91.3  50                 92.0  50
  4  12.4  7994  143.6  50    12.4  7924  140.5  50    12.0  7820  140.4  50    12.4  7648  134.3  50
  8  11.5  7898  167.9  50    11.6  7845  165.6  50    11.5  7868  163.7  50    11.5  7740  155.5  50
 12  10.6  8101  181.9  50    10.6  8061  179.0  50    10.7  7708  176.3  50    11.2  7853  166.6  50
 16  11.5  6988  192.3  50    11.1  7701  187.7  50    11.3  7573  184.9  50    11.3  7496  173.2  50
 20  10.7  8263  197.5  50    10.3  8264  194.1  50    10.2  8257  191.3  50    10.5  8142  181.8  50
 24  10.1  5862  203.9  50    10.4  5840  200.4  50     9.8  5849  196.3  50    10.2  5838  184.6  50
 28  10.8  8053  210.9  50    10.6  7942  206.5  50    10.2  7920  201.4  50    10.2  7805  188.9  50
 32  10.6  8106  219.6  50    10.0  8079  208.7  50     9.8  8081  206.2  50    10.3  8060  193.6  50
 36  10.6  8234  222.6  50    10.0  8209  215.6  50    10.2  8189  212.1  50     9.8  8178  198.2  50
 40  10.9  8170  224.2  50    10.5  8157  215.7  50    10.1  8090  212.8  50     9.8  8146  195.6  50
 44  10.5  7862  231.6  50     9.9  8087  221.5  50     9.9  8077  215.9  50     9.6  8056  198.2  50
 48  10.1  7919  234.0  50     9.6  7754  224.4  50     9.0  8223  217.6  50     8.4  8249  197.9  50
 52  11.2  8266  235.7  50    10.3  8256  227.0  50    10.0  8235  219.7  50     9.7  8228  200.7  50
 56  11.4  7999  243.4  49    10.9  8007  231.0  49    10.6  7991  224.5  49     9.9  8088  200.7  50
 60  10.9  8198  249.6  49    11.0  7908  235.6  49    10.7  7851  225.8  49    10.1  8309  201.6  50
 64  11.5  8125  257.9  49    11.0  7823  239.4  49    10.5  8084  231.9  49     9.8  8252  202.8  50
 68  11.4  7846  263.2  49    11.0  8068  249.0  49    10.9  8064  237.9  49     9.8  8218  205.5  50
 72  12.1  7958  270.3  48    11.3  8114  253.0  49    10.8  8082  241.0  49     9.9  8205  207.0  50
 76  11.7  7810  276.6  47    11.3  8141  260.4  48    11.3  8227  249.0  49     9.6  8395  207.8  50
 80  12.2  7812  284.6  47    11.5  7921  267.4  48    11.4  8107  257.4  49    10.0  8081  212.7  49
 84  12.3  7502  288.3  46    11.7  7442  268.2  47    11.0  7950  261.0  49    10.2  7908  211.5  49
 88  12.0  7434  293.1  45    11.0  7062  268.6  47    10.9  8079  261.6  49     9.9  8045  210.2  49
 92  11.3  7255  295.2  45    11.1  7189  271.7  44    10.5  7635  261.6  47    10.3  7650  211.6  47
 96  12.8  7171  293.1  44    11.9  7010  269.2  43    11.6  7490  261.8  46    10.2  7659  210.8  47
100  11.6  6859  293.0  41    11.8  5677  272.1  42    11.6  6626  266.2  40     9.5  6613  211.9  44
104  11.7  6337  293.8  39    11.2  6304  271.5  38    11.4  6334  267.2  39     9.6  6907  209.8  42

MEAN BODY WGT FOR WEEKS
1 TO 13          146.2                    143.8                    142.9                    137.1
14 TO 52         217.2                    210.2                    205.8                    191.3
 > 52            277.1                    258.3                    249.7                    208.0
=========================================================================================================

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.