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TDMS Study 05205-07 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                             P-NITROTOLUENE                                            DATE: 03/13/00    
EXPERIMENT: 05205 TEST: 07                                                                                        TIME: 13:55:08    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C62537D     
CONT: N01-ES-55393                                                                                                CAS: 99-99-0      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: SOUTHERN RESEARCH INSTITUTE                      P-NITROTOLUENE                                              DATE: 03/13/00


EXPERIMENT: 05205 TEST: 07                                                                                        TIME: 14:05:09


SPECIES: RATS, FISCHER 344                             


TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  62537D


CONT: N01-ES-55393                                                                                                CAS: 99-99-0

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
                                TWO YEAR DOSED FEED STUDY OF P-NITROTOLUENE

==========================================================================================================
WEEK     0       PPM            1250    PPM              2500    PPM              5000    PPM
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B       102.4       50       102.2     99.8    50     102.8    100.4    50     101.2     98.8    50
  1       102.4       50       102.2     99.8    50     102.8    100.4    50     101.2     98.8    50
  4       205.9       50       200.4     97.3    50     196.4     95.4    50     180.6     87.7    50
  8       281.5       50       273.1     97.0    50     269.6     95.8    50     246.1     87.4    50
 12       324.0       50       318.8     98.4    50     309.9     95.6    50     282.5     87.2    50
 16       352.2       50       342.0     97.1    50     336.4     95.5    50     303.4     86.1    50
 20       377.2       50       364.8     96.7    50     359.1     95.2    50     321.5     85.2    50
 24       390.4       50       380.8     97.5    50     368.3     94.3    50     334.7     85.7    50
 28       404.5       50       391.9     96.9    50     384.4     95.0    50     342.8     84.7    50
 32       421.3       50       404.3     96.0    50     393.6     93.4    50     352.4     83.6    50
 36       422.4       50       410.3     97.1    50     402.7     95.3    50     361.8     85.7    50
 40       425.7       50       413.7     97.2    50     405.1     95.2    50     361.3     84.9    50
 44       433.0       50       422.1     97.5    50     410.4     94.8    50     368.4     85.1    50
 48       436.0       50       425.8     97.7    50     417.9     95.8    50     370.1     84.9    50
 52       438.0       50       426.8     97.4    50     418.6     95.6    50     373.7     85.3    50
 56       434.9       49       423.4     97.4    50     415.0     95.4    50     373.3     85.8    50
 60       437.0       49       429.9     98.4    50     419.4     96.0    50     377.9     86.5    50
 64       439.5       49       431.5     98.2    50     424.5     96.6    50     381.0     86.7    50
 68       439.2       49       431.4     98.2    50     427.2     97.3    50     380.8     86.7    50
 72       437.5       49       427.9     97.8    49     424.5     97.0    50     384.9     88.0    48
 76       440.4       48       436.7     99.2    47     432.0     98.1    49     389.9     88.5    48
 80       443.8       48       436.5     98.4    47     432.6     97.5    49     389.6     87.8    48
 84       434.1       48       433.6     99.9    46     429.5     98.9    49     386.8     89.1    48
 88       431.5       45       428.0     99.2    44     423.7     98.2    49     384.7     89.2    46
 92       424.7       43       426.3    100.4    41     416.9     98.2    47     381.2     89.8    45
 96       419.4       41       419.5    100.0    40     412.1     98.3    46     379.9     90.6    45
100       410.4       37       415.4    101.2    39     408.9     99.6    42     373.7     91.1    41
104       402.1       33       409.0    101.7    39     402.0    100.0    41     366.0     91.0    40

TERM. SAC.            31                         38                       38                       40


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
                                TWO YEAR DOSED FEED STUDY OF P-NITROTOLUENE

==========================================================================================================
WEEK     0       PPM            1250    PPM              2500    PPM              5000    PPM
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        91.4       50        90.2     98.7    50      91.3     99.9    50      92.0    100.7    50
  1        91.4       50        90.2     98.7    50      91.3     99.9    50      92.0    100.7    50
  4       143.6       50       140.5     97.8    50     140.4     97.8    50     134.3     93.5    50
  8       167.9       50       165.6     98.6    50     163.7     97.5    50     155.5     92.6    50
 12       181.9       50       179.0     98.4    50     176.3     96.9    50     166.6     91.6    50
 16       192.3       50       187.7     97.6    50     184.9     96.2    50     173.2     90.1    50
 20       197.5       50       194.1     98.3    50     191.3     96.9    50     181.8     92.1    50
 24       203.9       50       200.4     98.3    50     196.3     96.3    50     184.6     90.5    50
 28       210.9       50       206.5     97.9    50     201.4     95.5    50     188.9     89.6    50
 32       219.6       50       208.7     95.0    50     206.2     93.9    50     193.6     88.2    50
 36       222.6       50       215.6     96.9    50     212.1     95.3    50     198.2     89.0    50
 40       224.2       50       215.7     96.2    50     212.8     94.9    50     195.6     87.2    50
 44       231.6       50       221.5     95.6    50     215.9     93.2    50     198.2     85.6    50
 48       234.0       50       224.4     95.9    50     217.6     93.0    50     197.9     84.6    50
 52       235.7       50       227.0     96.3    50     219.7     93.2    50     200.7     85.2    50
 56       243.4       49       231.0     94.9    49     224.5     92.2    49     200.7     82.5    50
 60       249.6       49       235.6     94.4    49     225.8     90.5    49     201.6     80.8    50
 64       257.9       49       239.4     92.8    49     231.9     89.9    49     202.8     78.6    50
 68       263.2       49       249.0     94.6    49     237.9     90.4    49     205.5     78.1    50
 72       270.3       48       253.0     93.6    49     241.0     89.2    49     207.0     76.6    50
 76       276.6       47       260.4     94.1    48     249.0     90.0    49     207.8     75.1    50
 80       284.6       47       267.4     94.0    48     257.4     90.4    49     212.7     74.7    49
 84       288.3       46       268.2     93.0    47     261.0     90.5    49     211.5     73.4    49
 88       293.1       45       268.6     91.6    47     261.6     89.3    49     210.2     71.7    49
 92       295.2       45       271.7     92.0    44     261.6     88.6    47     211.6     71.7    47
 96       293.1       44       269.2     91.8    43     261.8     89.3    46     210.8     71.9    47
100       293.0       41       272.1     92.9    42     266.2     90.9    40     211.9     72.3    44
104       293.8       39       271.5     92.4    38     267.2     90.9    39     209.8     71.4    42

TERM. SAC.            39                         37                       39                       41


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.