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TDMS Study 05210-03 Pathology Tables

NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49




       Facility:  I. I. T. Research Institute

       Chemical CAS #:  100-41-4

       Lock Date:  10/02/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1


NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|             
                                           | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Arteriole, Inflammation              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  A  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             
      Basophilic Focus                     |          1        1     2  2        2     2        1        2  1  1     1|             
      Clear Cell Focus                     |                                              1                           |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |             2                                                            |             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |    2        X                                                        X   |             
      Inflammation, Chronic                |    1                                         1                           |             
      Mixed Cell Focus                     |          1                                                              3|             
      Necrosis                             |                            2                                             |             
      Vacuolization Cytoplasmic            |       1  1                          2  3        1                        |             
      Centrilobular, Degeneration          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Necrosis                        |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|             
                                           | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation                         |                                                                         2|             
      Acinus, Atrophy                      |                2           2  1        2  2        2     2  1     2  2   |             
      Artery, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                2     3                                                   |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                      2                 2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
      Necrosis                             |                2                                         2               |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      2                       1                           |             
      Valve, Degeneration                  |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                  2           1         |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 | 2                                                                 2      |             
      Hemorrhage                           |                                     2                                3   |             
      Hyperplasia                          |                                                 2           2            |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    2  2                                                  2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|             
                                           | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1  1            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Hyperplasia                          |                2                                   1                     |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                                                         |             
      Infiltration Cellular, Mixed Cell    |                                        3                                 |             
      Necrosis                             |                                        3                                 |             
      Pars Distalis, Angiectasis           |                                              4                 2         |             
      Pars Distalis, Cyst                  |                            2                             3  2     2      |             
      Pars Distalis, Hyperplasia           |          2                          3           2           2  1     3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      C-Cell, Hyperplasia                  | 2  2                 2                                            1      |             
      C-Cell, Inflammation                 |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |          3                    3                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     2     2     3                        |             
      Corpus Luteum, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|             
                                           | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Hydrometra                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Hemorrhage                           |       2                                                                  |             
      Hyperplasia                          |                            1        2                    3               |             
      Myelofibrosis                        |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                                            +               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  M  M  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                3                                                        2|             
      Pigmentation                         |                         1                    1  1                       2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2              2                 4                                    |             
      Hyperplasia, Plasma Cell             |             3                                                            |             
      Infiltration Cellular, Histiocyte    |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                     3              3     3  2  1         |             
      Infiltration Cellular, Histiocyte    |                                        2                                 |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1                       3           3  2  2              3     1  2     2|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                                        2                                 |             
      Pigmentation                         | 2     2  1              2  1              2        1        1     2      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     3                    2  2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|             
                                           | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pigmentation                         |                                                                          |             
      Red Pulp, Atrophy                    |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Galactocele                          |    3  3              3                    2  2                    2      |             
      Hyperplasia                          |          2  2     2  3                 2     1     2           1         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         2                                                |             
      Ulcer                                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                              2              2            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                    3  2               |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|             
                                           | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                        2                                 |             
      Inflammation, Chronic                |                                        2                                 |             
      Inflammation, Granulomatous          |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |    1                                                                 2   |             
      Inflammation                         | 1  3                          2                             2        3   |             
      Thrombosis                           |                                        2                                 |             
      Nasolacrimal Duct, Inflammation      |                                              3        2                  |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                         3                                                |             
      Respiratory Epithelium, Hyperplasia  |    2                                                                 2   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                +        +|             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Lens, Cataract                       |                                                    2                     |             
      Retina, Degeneration                 |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             3            |             
      Infarct                              |                                                                          |             
      Mineralization                       |                1           1              1           1                  |             
      Nephropathy                          | 1  1  1  1  1  1  2     1  1  1     1        2  2  1     2  1     1  1  1|             
      Pigmentation                         |                3                                                     3   |             
      Arteriole, Inflammation              |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation                         |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Arteriole, Inflammation              | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +|  44        |
      Inflammation                         |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A|  41        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  A  +  +  A  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  A|  41        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                             1     1      |      3  1.0|
      Basophilic Focus                     | 2  1  1  1  1     2  2     1                    1     1           2  1   |     23  1.4|
      Clear Cell Focus                     |                      1              1                                    |      3  1.0|
      Congestion                           |                                                                2         |      1  2.0|
      Eosinophilic Focus                   |                3                                                         |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                            1                                             |      1  1.0|
      Hepatodiaphragmatic Nodule           |          3                                                               |      4  2.5|
      Inflammation, Chronic                |                                                          1               |      3  1.0|
      Mixed Cell Focus                     |          1           2              2                                    |      5  1.8|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                         3  2  3                             1     1  1   |     11  1.7|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                    +        +  +                          +     +      |   7        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Artery, Inflammation                 | 4                                                                        |      1  4.0|
      Fat, Necrosis                        |                      2        2  3                          2     3      |      6  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1                                                                        |      2  1.5|
      Acinus, Atrophy                      |                   1           1        2        2        1     2  2  1   |     18  1.7|
      Artery, Inflammation                 | 4                                                                        |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                         2        3                                       |      2  2.5|
      Hyperplasia                          |                                  3                                       |      3  2.7|
      Inflammation                         |                3                                                         |      1  3.0|
      Ulcer                                |                                  4                                       |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                         2                 2  2                           |      5  2.0|
      Pigmentation                         |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Aorta, Inflammation                  | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                   1                 1           1                    1   |      6  1.2|
      Valve, Degeneration                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      3  1.7|
      Cytoplasmic Alteration               |                      3                                                   |      1  3.0|
      Degeneration, Cystic                 |       1                                   2                          2   |      5  1.8|
      Hemorrhage                           |                         2                    4                           |      4  2.8|
      Hyperplasia                          |       2                                                                  |      3  2.0|
      Necrosis                             | 3                                                                        |      1  3.0|
      Vacuolization Cytoplasmic            | 2                             3  3  1     3           1           1  1  3|     12  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               2                    2                     |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          | 1                                                     2  1               |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  |                                                                         3|      5  2.4|
      Pars Distalis, Hyperplasia           |    3                 2     2     3              3                        |     11  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         | 3                                                                        |      1  3.0|
      C-Cell, Hyperplasia                  |                                                          1               |      5  1.6|
      C-Cell, Inflammation                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |    2  3                             2                 2                  |      4  2.3|
      Inflammation                         |                               3     2              3  2                  |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    3                                            2                        |      5  2.4|
      Corpus Luteum, Hyperplasia           |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Hemorrhage                           |                         4                    3                           |      3  3.0|
      Hyperplasia                          | 3                 2                       3                             3|      7  2.4|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                         +|   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  M  M  +  +  +  +  +|  37        |
      Atrophy                              |                                              2                           |      1  2.0|
      Hemorrhage                           |    2                                            2                        |      4  2.3|
      Pigmentation                         |    2                                                                 1   |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      3  2.7|
      Hyperplasia, Plasma Cell             |                         3                                                |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Amyloid Deposition                   |                               3                                          |      1  3.0|
      Atrophy                              |                                              3                           |      1  3.0|
      Hemorrhage                           |                                                    3     2        1      |      8  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation                         |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |    1  1  2                 1     2              2  3  2  1     2     2  2|     21  1.9|
      Hyperplasia, Plasma Cell             | 2                                                                        |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                  2                                       |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |    2  2  2     1     1     2  2     1     2              1  2     1  2   |     22  1.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 3                                         3                             2|      6  2.5|
      Pigmentation                         |                         4                                                |      1  4.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Galactocele                          |             2        2  1  2                                             |     10  2.2|
      Hyperplasia                          |             2                 2           2              1           2   |     13  1.8|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
      Hyperostosis                         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           1                              |      1  1.0|
      Necrosis                             | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Metaplasia, Squamous                 |                                                                1         |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                              2                 2         |      5  2.2|
      Fibrosis                             |       1                                                                  |      1  1.0|
      Hemorrhage                           |          2                                                               |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                             2            |      2  2.0|
      Inflammation, Chronic                |                               2                                          |      2  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                         3|      1  3.0|
      Foreign Body                         |                   2                                   1                  |      4  1.5|
      Inflammation                         |                   2  2     1                 1        1                  |     10  1.8|
      Thrombosis                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      2  2.5|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                   2  1     1                          1                  |      6  1.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1|            |
                                           | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    CONTROL                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   3        |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Infarct                              | 3                                                                        |      1  3.0|
      Mineralization                       |                                              1           1  1  2         |      8  1.1|
      Nephropathy                          | 2  1  2  2  2     1  1  1  2  1  1  2  1        1     1  1  1     2  1   |     38  1.3|
      Pigmentation                         |                               1                    3                     |      4  2.5|
      Arteriole, Inflammation              | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|             
                                           | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    1           1  1     1  2  1  1     1  1     1  3  1  2  1  1         |             
      Clear Cell Focus                     |                                        1                                 |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |                                     3                             2      |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   3        3                                             |             
      Inflammation, Chronic                |                                        1              3                  |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    1                                2              2     1  1            |             
      Portal Vein, Thrombosis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Necrosis                        |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1                    2     1     2        2     2        2  2  1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|             
                                           | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Ulcer                                |             3        4                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |             3        3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                1         |             
      Endocardium, Hyperplasia             |                                                       3                  |             
      Myocardium, Hypertrophy              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Cytoplasmic Alteration               |       1        2                                                         |             
      Degeneration, Cystic                 |                                  2     2                                 |             
      Hemorrhage                           |       1                                   1        2                     |             
      Hyperplasia                          | 1           3                                               2            |             
      Vacuolization Cytoplasmic            |          2                                                           3   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Pars Distalis, Angiectasis           | 3  1                          1        2  2  1              3            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Degeneration          |                                                                   4      |             
      Pars Distalis, Hemorrhage            |             1                                                     4      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|             
                                           | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Hyperplasia           |             2     2              1                 2     2               |             
      Pars Distalis, Pigmentation          |             2                                                     3      |             
      Pars Intermedia, Angiectasis         |                            3                                             |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      2     1           1                       2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
      Inflammation                         |                3              2                                2         |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                    2                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                              2                           |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                    +                     |             
      Fibrosis                             |                                                                          |             
      Arteriole, Degeneration              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Mast Cell               |                                                                          |             
      Hyperplasia                          |                                                 2  3                    2|             
      Myelostromal Proliferation           |                                        4                                 |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                                +                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|             
                                           | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hemorrhage                           | 1                             3        1                       1         |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Pigmentation                         | 2                          1  2                                1         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |       2                                                                  |             
      Hyperplasia, Plasma Cell             |                                  3  2                 2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                3              2           2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Edema                                |                                                                          |             
      Hemorrhage                           |    2  3                       2           1        2     2  1            |             
      Pigmentation                         | 1     1           1           2  2  2              2     2  1  2  2      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2                                               3                     |             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |          3                 2              2     3     3           2      |             
      Hyperplasia                          | 2     1     1     2        2        2     1  2                 2         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|             
                                           | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |    3              3                                   3                  |             
      Turbinate, Hyperostosis              |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                       2  2                                             |             
      Inflammation                         |                   1                                         2            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                             2            |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |             2                                                            |             
      Infiltration Cellular, Histiocyte    |                   2           2                                          |             
      Inflammation, Granulomatous          |       1                                                                  |             
      Alveolar Epithelium, Hyperplasia     |                   2           1                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation                         |          2        1                 3                    1               |             
      Glands, Hyperplasia                  |                                                                          |             
      Nasolacrimal Duct, Inflammation      | 3                                                                        |             
      Respiratory Epithelium, Hyperplasia  |                                     2                                    |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |          2                                                               |             
      Respiratory Epithelium, Ulcer        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|             
                                           | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |    1                             1                 1                 1  1|             
      Nephropathy                          | 1  1  2  2  1  1  2     2  1  1  1  3  1  1     2     2  1  1  1  1      |             
      Pigmentation                         |          2                                                               |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2  2  2     1  1     1  1        1                 1  1     1  2  1  1   |     29  1.3|
      Clear Cell Focus                     | 2                                                              1         |      3  1.3|
      Degeneration                         |                                                          3               |      1  3.0|
      Eosinophilic Focus                   |       1                                                                  |      3  2.0|
      Fibrosis                             |                                     1                                    |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                     4                                   2|      4  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Necrosis                             |                                                          3               |      1  3.0|
      Vacuolization Cytoplasmic            | 2                    1  1                    4  2        3     1         |     12  1.8|
      Portal Vein, Thrombosis              |                                                          4               |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                                      +                                +|   4        |
      Fat, Necrosis                        | 2                                      3                                3|      4  2.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 2  1                    2     1  1                 1  2           1     1|     18  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            3                                             |      1  3.0|
      Inflammation                         |                                                 3                        |      1  3.0|
      Ulcer                                |          4        4                                                      |      4  3.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |          2                 2                                             |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
      Endocardium, Hyperplasia             |                                                                          |      1  3.0|
      Myocardium, Hypertrophy              |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                    2                                                |      3  2.0|
      Cytoplasmic Alteration               |                                     3                                    |      3  2.0|
      Degeneration, Cystic                 |             2                                                            |      3  2.0|
      Hemorrhage                           |                   3                                      3               |      5  2.0|
      Hyperplasia                          |    1                                                                     |      4  1.8|
      Vacuolization Cytoplasmic            |                                              2              2           2|      5  2.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Necrosis                             |                   4                                                      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |          3        2                                                      |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |             3     2  3  3  2        4                 2  3              4|     16  2.4|
      Pars Distalis, Cyst                  | 2                                                                        |      1  2.0|
      Pars Distalis, Degeneration          |                                                                          |      1  4.0|
      Pars Distalis, Hemorrhage            |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           |       3     1  2                                               2         |      9  1.9|
      Pars Distalis, Pigmentation          |                                                                          |      2  2.5|
      Pars Intermedia, Angiectasis         |                                        3                                 |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                  2                                       |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                  2                       2               |      3  2.0|
      Inflammation                         |                                     2                          3         |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      3        2        4                          1      |      6  2.5|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |       2                                                                 2|      3  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                               +                          +               |   3        |
      Fibrosis                             |                                                          3               |      1  3.0|
      Arteriole, Degeneration              |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                     3                          2         |      2  2.5|
      Hyperplasia, Mast Cell               |       2                                                                  |      1  2.0|
      Hyperplasia                          |    2     2                       2           2           2               |      8  2.1|
      Myelostromal Proliferation           |                                                                          |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  M  +  M  M  M  +  M  M  +  +  +  M  +  +  M  +  +|  34        |
      Hemorrhage                           |                      2                                         2         |      6  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         |       1              2                          1                        |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                3                                                         |      1  3.0|
      Hemorrhage                           | 3                                                                        |      2  2.5|
      Hyperplasia, Plasma Cell             |    2        2                             2                       2  4  2|      9  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                          2        1      |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                          2               |      1  2.0|
      Hemorrhage                           |                         1           2  3           1     2     2  1  3   |     15  1.9|
      Pigmentation                         |    2  1                 1           1  3  1  2  2  1           2        1|     22  1.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                              2                           |      3  2.3|
      Hemorrhage                           |                                                                         3|      2  3.0|
      Hyperplasia, Lymphoid                |                                                          3               |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                           3                    2     3  3|     10  2.6|
      Hyperplasia                          |          2  2  1        1        2  2  2              2     2     2      |     19  1.7|
      Infiltration Cellular, Lymphocyte    |                                           4                              |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                           4                              |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |          3                                                               |      1  3.0|
      Hyperostosis                         |                3        4                                                |      5  3.2|
      Turbinate, Hyperostosis              |                         3                                                |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  M  +|  43        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
      Inflammation                         |                                                                          |      2  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                              2                           |      1  2.0|
      Fibrosis                             |                                              2                           |      1  2.0|
      Hemorrhage                           |                                                                      1   |      2  1.5|
      Infiltration Cellular, Histiocyte    |    1                                                                     |      3  1.7|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |             2           2     2                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                        1                                 |      1  1.0|
      Inflammation                         |          3  2  2                       2                          3  3   |     10  2.2|
      Glands, Hyperplasia                  |                                                                   2      |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |          2  2  2                    1  2                          2      |      7  1.9|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Respiratory Epithelium, Ulcer        |                                                                   1  2   |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             3                                                            |      1  3.0|
      Mineralization                       |    1                             1        2  1  1                 1      |     11  1.1|
      Nephropathy                          | 1     2  4  2  2  1  1  1     2  3  2  1  2  2  1  1     1  2  2  2  1  2|     42  1.6|
      Pigmentation                         |       2     1              3           1  1  1  1     2           1      |     10  1.5|
      Renal Tubule, Hyperplasia            |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3|            |
                                           | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    75 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|             
                                           | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
      Inflammation                         |                                                       4                  |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  1  2     1        2  1  1     1  1     2     1  1  1  1  1     1     1|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration                         |                                           2                              |             
      Eosinophilic Focus                   |                            2           2                          3      |             
      Hepatodiaphragmatic Nodule           |       X                    3                                      2      |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Inflammation, Chronic                |             1                    2                                       |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                           2                              |             
      Vacuolization Cytoplasmic            | 1     2                       1  3        2     1  1        1           3|             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +                                   +        +     +           +   |             
      Artery, Degeneration                 |       4                                                                  |             
      Artery, Inflammation                 |       3                                                                  |             
      Fat, Necrosis                        |                                           3        2     3           2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
      Acinus, Atrophy                      | 1  3  2           2              2  1  3              1     2     1  1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|             
                                           | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Arteriole, Inflammation              |       3                                                                  |             
      Artery, Inflammation                 |                                                                         2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                2                                                         |             
      Hyperplasia                          |                2                                                     3   |             
      Ulcer                                |                                           2                              |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Tongue                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |       4                                                                  |             
      Inflammation                         |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Atrium, Inflammation                 |                                                       3                  |             
      Endocardium, Hyperplasia             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2                    2                                                |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2                             2                                          |             
      Hypertrophy                          |                               2                                          |             
      Necrosis                             |          2                                                               |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                2              2        2                 2           3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|             
                                           | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2     1                                                         |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                1                             2                           |             
      Pars Distalis, Cyst                  |                                                       1                  |             
      Pars Distalis, Hyperplasia           |    3  2  3  2     2                       2                 3     1      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      C-Cell, Hyperplasia                  |                         1              1              1                  |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                    3              2  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                    2        2                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Inflammation                         |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|             
                                           | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3     2              2           3                  |             
      Myelostromal Proliferation           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                                                  +   |             
      Pancreatic, Hemorrhage               |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  M  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                3     2                                      1            |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2                                                           1            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                3                                                         |             
      Hyperplasia, Plasma Cell             |                                     2  2              2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      3                                3                  |             
      Hemorrhage                           |                2           2                    2                    3   |             
      Hyperplasia, Plasma Cell             |                                                       3                  |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1     3                 2     1     1     2        2  2                  |             
      Pigmentation                         | 1     1                 2     1  1  1     2        2        1  2  1     1|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           3           3                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|             
                                           | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Galactocele                          |                         2                    4                          2|             
      Hyperplasia                          | 2  2     2        2     2     2  2     1     2     2           2  1     1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                     2                                    |             
      Epidermis, Hyperplasia               |                                     2                                    |             
      Subcutaneous Tissue, Inflammation    |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2                       4              2                           |             
      Turbinate, Hyperostosis              |       2                       4                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                               3                                          |             
      Inflammation                         |                                        1                                 |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                      2                                                   |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             1            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|             
                                           | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation                         |    1                    1                             2                  |             
      Necrosis                             |                                                       2                  |             
      Glands, Cyst                         |                                                                          |             
      Glands, Hyperplasia                  |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |             +                                                  +         |             
      Lens, Cataract                       |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                              3                           |             
      Mineralization                       |    1        1  2                          1                    2         |             
      Necrosis                             |          4                                                               |             
      Nephropathy                          | 2  2  1  1  1  2  1     2  2  2  2  2  1  1     2  1     2  2  3  1  2  3|             
      Pigmentation                         |                                        1     2                           |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                          3               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    1     1     1  1  2     1  1     1     1  1  1  1  1  1  1     2      |     33  1.2|
      Clear Cell Focus                     |                                                                   1      |      1  1.0|
      Congestion                           |                                                          2               |      1  2.0|
      Degeneration                         |                                  3                                       |      2  2.5|
      Eosinophilic Focus                   |          1           2        2              2        1                  |      8  1.9|
      Hepatodiaphragmatic Nodule           |                                     2                                    |      4  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |             1                                                            |      3  1.3|
      Mixed Cell Focus                     |                            2                                             |      1  2.0|
      Necrosis                             |                                  2                                       |      2  2.0|
      Vacuolization Cytoplasmic            |                2     2           2     3  1                              |     14  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   6        |
      Artery, Degeneration                 |                                                                          |      1  4.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Fat, Necrosis                        |                         3                                                |      5  2.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 2              2                       2  1           1           2     2|     18  1.7|
      Arteriole, Inflammation              |                                                                          |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia                          |       3                                                                  |      3  2.7|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                  3                                       |      1  3.0|
      Atrium, Inflammation                 |                                                                          |      1  3.0|
      Endocardium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                                                                     |      4  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Cytoplasmic Alteration               |          3                                                               |      1  3.0|
      Degeneration, Cystic                 |          1                                               2               |      2  1.5|
      Hemorrhage                           |                2                 2                                       |      2  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Hypertrophy                          |    2     1                                                               |      3  1.7|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                  2                                       |      1  2.0|
      Vacuolization Cytoplasmic            |       2        3        2  3  1  2                       1               |     12  2.1|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  M  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +|  42        |
      Hyperplasia                          |                                     1                 2        2         |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |          3  3              2                                            2|      6  2.2|
      Pars Distalis, Cyst                  |                                                                   1  2   |      3  1.3|
      Pars Distalis, Hyperplasia           |    2                                      4  2     3           2  2      |     14  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1                                                            |      1  1.0|
      C-Cell, Hyperplasia                  |                2  1                                                      |      5  1.2|
      Follicle, Cyst                       |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hyperplasia                          |    2                                                                     |      1  2.0|
      Inflammation                         |                                        2                                 |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       1                             2                                    |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                                      3   |      1  3.0|
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2        3        3                                       |      7  2.6|
      Myelostromal Proliferation           |                                                    4                     |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                         +                                      +         |   4        |
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|  41        |
      Ectasia                              |                                  2                                       |      1  2.0|
      Hemorrhage                           |                            1     1                                       |      5  1.6|
      Infiltration Cellular, Histiocyte    |                                  3                                       |      1  3.0|
      Necrosis                             |                                  3                                       |      1  3.0|
      Pigmentation                         |          1  1        1     1                    1                        |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          2                                                               |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                      2                                                   |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                           1                              |      3  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hemorrhage                           |          1           2     1  3                                          |      8  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation                         |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   1                             1  2     2  2            |     13  1.7|
      Pigmentation                         |          1  2     2  2        1        1     1  2  2  1  1  1           1|     25  1.4|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                  2                                       |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          | 2        1     2     1        2                       1              2   |     10  1.9|
      Hyperplasia                          |                3  2     2  2     1  2     1           1                  |     21  1.8|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                3                                                         |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epidermis, Hyperplasia               |                                     2                                    |      2  2.0|
      Subcutaneous Tissue, Inflammation    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |             2     3                                                      |      5  2.6|
      Turbinate, Hyperostosis              |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                     1                                    |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                          2               |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Fibrosis                             |                      1                                                   |      1  1.0|
      Hemorrhage                           |                            1  1                                          |      2  1.0|
      Infiltration Cellular, Histiocyte    |          1                                                               |      1  1.0|
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
      Inflammation, Granulomatous          |                               1                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       2                  |      1  2.0|
      Inflammation                         | 2        1                                                               |      5  1.4|
      Necrosis                             |                                                                          |      1  2.0|
      Glands, Cyst                         |                         2                                                |      1  2.0|
      Glands, Hyperplasia                  | 2        2                                                               |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |          2     1     1        1                                          |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   3        |
      Lens, Cataract                       |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8|            |
                                           | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    250                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                           1                             1|      7  1.3|
      Necrosis                             |                                                                          |      1  4.0|
      Nephropathy                          | 2  2  1  2  1  1  1  2     2  2  2  2  2  2  2  1  1     2  2     2  2   |     43  1.7|
      Pigmentation                         |          1                 1     3  1           1                       3|      8  1.6|
      Renal Tubule, Degeneration           |                                  3                                       |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                    3        1            |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|             
                                           | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                        2           1     3               |             
      Basophilic Focus                     | 1        1  1     1     1  1  2           1  1  1     1           1  1  1|             
      Clear Cell Focus                     |          1                 1                                             |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   | 2                             3  2                                       |             
      Hepatodiaphragmatic Nodule           |                            2     3                                       |             
      Inflammation, Acute                  |                                                    1                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                     4                                    |             
      Vacuolization Cytoplasmic            | 3        1              1              2  1  1                    2     1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +                 +  +              +  +      |             
      Fat, Necrosis                        |                            2                 2  2              3  3      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Acinus, Atrophy                      |          1  1     1     2        1                                1      |             
      Arteriole, Inflammation              |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|             
                                           | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             
      Hyperplasia                          |                                        2                                3|             
      Inflammation                         |                                                                         1|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
      Glands, Cyst                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy                       | 2                       1  1        1                                    |             
      Fibrosis                             |                                                          3               |             
      Atrium, Thrombosis                   |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic                 |                         3                                                |             
      Degeneration                         |             2                                                            |             
      Hemorrhage                           |                      2                                                   |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                      1                                                   |             
      Vacuolization Cytoplasmic            |                      2  3                                3     1        1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|             
                                           | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          | 1                                      2                 1               |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           |    3                                                                    2|             
      Pars Distalis, Cyst                  |                      2                    2                              |             
      Pars Distalis, Hyperplasia           |          2     2           3              2     3        2           3  1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Bilateral, C-Cell, Hyperplasia       |                                                                          |             
      C-Cell, Hyperplasia                  |                                           3           2  1     2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                    2                     |             
      Inflammation                         |                                                          1           3   |             
      Bilateral, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                                  2        2  2           2               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hydrometra                           |          4                                2              3               |             
      Inflammation                         |          2                                                               |             
      Endometrium, Cyst                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              | 2                                                                        |             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|             
                                           | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |                               2        2        2              3  3      |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                       +           +               |             
      Pancreatic, Hemorrhage               |                      2                                                   |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                      3                                                   |             
      Renal, Hemorrhage                    |                                              3                           |             
      Renal, Pigmentation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +     +  +  +  +|             
      Hemorrhage                           | 1                                                                        |             
      Pigmentation                         | 1                                1           2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Hyperplasia, Plasma Cell             |                                              2                           |             
      Pigmentation                         |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           | 2                    2  1     3                 3                        |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           | 1        1  2        2        2  2           2     3                 2   |             
      Pigmentation                         | 2        2  2  2  2           2     1  2  1  2        1           2  2  1|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
      Necrosis                             |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Galactocele                          | 2           2                             2           2  1        3     2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|             
                                           | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |    2                       2  3        2     1  2  2  2        2     1  3|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Ulcer                                |                                                 2     2                  |             
      Epidermis, Hyperplasia               |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Turbinate, Hyperostosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +     +  +  +  +|             
      Inflammation                         |                                  2                                1      |             
      Respiratory Epithelium, Hyperplasia  |                                  2                                       |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 2        2               |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                  1                                       |             
      Inflammation, Chronic                |             1                             1                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
      Inflammation                         |                                                                          |             
      Glands, Hyperplasia                  |                               3                                          |             
      Goblet Cell, Hyperplasia             |                2                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|             
                                           | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation                         |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                      2                                                   |             
      Nephropathy                          | 3  3  1  2  2  1  2  1  3  3  1  4  4  3  2  4  1  1  2  3     2  3  2  4|             
      Pigmentation                         |                               1                                          |             
      Renal Tubule, Hyperplasia            |                                  1                                      1|             
      Transitional Epithelium, Hyperplasia |                                                          1               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 2           1  3                                                         |      6  2.0|
      Basophilic Focus                     |          1  1     1  1     1  1  1     2     2  1  2  2  1        1  1   |     29  1.2|
      Clear Cell Focus                     |          1                                   1                           |      4  1.0|
      Congestion                           |                                                          2               |      1  2.0|
      Eosinophilic Focus                   |                                        2                                2|      5  2.2|
      Hepatodiaphragmatic Nodule           |          X                 X                                      1      |      5  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                   2                                                     2|      2  2.0|
      Necrosis                             |                                                                         1|      2  2.5|
      Vacuolization Cytoplasmic            |       1     2           1  1  1        3                                 |     14  1.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                 +                       +|   7        |
      Fat, Necrosis                        |                                                 2                       2|      7  2.3|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      | 2     2  1  2  1  1              1  2     4     2           2        1  1|     19  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Arteriole, Inflammation              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          | 3        1     3                    3  3                 2               |      8  2.5|
      Inflammation                         | 2              3                    2  2                 2               |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                 2                        |      1  2.0|
      Inflammation                         | 1                                      1                                 |      2  1.0|
      Necrosis                             |                                                             2            |      1  2.0|
      Ulcer                                |                                                             2            |      1  2.0|
      Glands, Cyst                         |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       |       2                             2                                    |      6  1.5|
      Fibrosis                             |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                    1              1  1   |      3  1.0|
      Degeneration, Cystic                 |                                           1  2        2                  |      4  2.0|
      Degeneration                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          |                                              1  2  1                     |      3  1.3|
      Necrosis                             |       2                                                                  |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                        2                                 |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2                       2                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 2                                                  1                     |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Cyst                  |                                     2                                    |      3  2.0|
      Pars Distalis, Hyperplasia           |                   1  3     1                 2  2  2  2        3     1   |     17  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, C-Cell, Hyperplasia       |                                                                         2|      1  2.0|
      C-Cell, Hyperplasia                  |                                     1                                    |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 | 4                                                                        |      1  4.0|
      Hyperplasia                          |                2                 2                                       |      3  2.0|
      Inflammation                         | 2              2                                                         |      4  2.0|
      Bilateral, Hyperplasia               |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                            2                                             |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydrometra                           |                            2                                             |      4  2.8|
      Inflammation                         |                                                                          |      1  2.0|
      Endometrium, Cyst                    |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Hemorrhage                           |       4                                                                  |      1  4.0|
      Hyperplasia                          |                   2                                   2        2         |      8  2.3|
      Erythroid Cell, Hyperplasia          |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   4        |
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Renal, Hemorrhage                    | 2                                                                        |      2  2.5|
      Renal, Pigmentation                  | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  M  +  +  +  M  +  +  M|  38        |
      Hemorrhage                           |                      3                                            2      |      3  2.0|
      Pigmentation                         |                1        1                                                |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                2                                                        1|      3  1.3|
      Hyperplasia, Plasma Cell             |       2        2                                                         |      3  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                           3           2                  |      7  2.3|
      Hyperplasia                          |                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |          1  2  2  2  1  3              3  1  2     2  2                 1|     21  1.9|
      Pigmentation                         |          1  2  2     1  2     1           1  2  2              1  1  1  2|     27  1.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                 2        2               |      3  2.3|
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                     2                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                            2           3        4                    3   |     11  2.4|
      Hyperplasia                          |                3                 1        3     2     1  2        2      |     18  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      2  2.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperostosis                         |                               2                                          |      1  2.0|
      Turbinate, Hyperostosis              |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                         2|      1  2.0|
      Hydrocephalus                        |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation                         |                                                                          |      2  1.5|
      Respiratory Epithelium, Hyperplasia  |                                        2                                 |      2  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Histiocyte    | 2                                                  1                     |      3  1.3|
      Inflammation, Chronic                |                                                                      1   |      3  1.0|
      Inflammation, Granulomatous          |                                        2                          2      |      2  2.0|
      Alveolar Epithelium, Hyperplasia     | 2                       2                    1     2                     |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                   1      |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation                         |                                                                   2      |      1  2.0|
      Glands, Hyperplasia                  |                                                                          |      1  3.0|
      Goblet Cell, Hyperplasia             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   1        |
      Lens, Cataract                       |                                                                      2   |      1  2.0|
      Retina, Degeneration                 |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3|            |
                                           | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    750                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                           2              2              3|      4  2.3|
      Nephropathy                          | 4        1  2  3  2  2  2  2  2  2     4  3  2  1  2  1  4  2  2  2  3  3|     46  2.3|
      Pigmentation                         |                                                                   2  2   |      3  1.7|
      Renal Tubule, Hyperplasia            |                                        2                                 |      3  1.3|
      Transitional Epithelium, Hyperplasia | 1                                                                        |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1              2           1              1     1                        |             
      Clear Cell Focus                     |                                                    1                     |             
      Degeneration, Cystic                 |          2        2           1                    1  1  3     2  2      |             
      Degeneration                         |                                        3                                 |             
      Eosinophilic Focus                   |                                                 1        2               |             
      Inflammation, Chronic                |       1                                                                  |             
      Mixed Cell Focus                     |                                                    2                     |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |       1        2                       2           1                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Necrosis                        |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                               2  2        2     2  2  1  2  3        2  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Hyperplasia                  |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                      2   |             
      Hyperplasia                          |    2           2              3     2                                   2|             
      Inflammation                         |                                                                      3   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |    4  3        4     3                                               2   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      2                                               2   |             
      Mineralization                       |                2                                2                        |             
      Necrosis                             |          1                    2                                   2      |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1        1  2  1  2              2        3  1  2  2     2     1   |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |    3                             3  3                                    |             
      Valve, Fibrosis                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                           2                              |             
      Hyperplasia                          |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |    3  2                       1        1           1        2  2     2   |             
      Bilateral, Atrophy                   |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2  2        1     2        2            |             
      Bilateral, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |       1        3  1        1                    4        2               |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            3                    4                        |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                            3        1              2     2     3         |             
      Pars Distalis, Pigmentation          |                                              2                           |             
      Pars Intermedia, Angiectasis         |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                             2                           |             
      Follicle, Cyst                       |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |    4           3  2        2        2        4              3           3|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
      Inflammation                         |       3              2  3  2     4              3     2                  |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3           3              2        3                                 |             
      Hemorrhage                           |                   2                                                      |             
      Bilateral, Atrophy                   | 3                                3              3                 4  3   |             
      Interstitial Cell, Hyperplasia       | 1           1                 1        2        1     1     1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                              2                           |             
      Hyperplasia                          |                                        2        2     1  1               |             
      Myelofibrosis                        |                                     3  2        3                        |             
      Myeloid Cell, Atrophy                |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +     +                    +  +              +              +         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Hemorrhage                           |                                     1           2     3                  |             
      Pigmentation                         |                1                          1                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         1|             
      Hyperplasia, Plasma Cell             |                                              3              2            |             
      Pigmentation                         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                             2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     3                                    |             
      Hemorrhage                           |       2     2  2  2                 3              3  3              1   |             
      Hyperplasia, Plasma Cell             |                                  2                                       |             
      Infiltration Cellular, Histiocyte    |                                        3                                 |             
      Pigmentation                         |       2        2  1        1                                            2|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Congestion                           |                   3                                                      |             
      Fibrosis                             |                            3                                             |             
      Hematopoietic Cell Proliferation     |                                        4                                 |             
      Necrosis                             |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       2              3                 2  1                          2  2|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                 2                        |             
      Pigmentation                         |                                                                2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                             4            |             
      Hyperkeratosis                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Fibrous Osteodystrophy               |                                                                          |             
      Turbinate, Hyperostosis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                  2                             2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                 2                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                        3                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              2     1                     |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Foreign Body                         |                                                             2            |             
      Inflammation                         |                3           1                                2     4      |             
      Goblet Cell, Hyperplasia             |                                                             2            |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                2                                                         |             
      Respiratory Epithelium, Inflammation |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                   3      |             
      Respiratory Epithelium, Ulcer        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|             
                                           | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Infarct                              |          2                       2                                       |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                              2                           |             
      Nephropathy                          | 2  3  2     3  3  3  2  2  3  1  2  2  2  2  1  4  2  1  2  1  2  1  4  2|             
      Pigmentation                         |    2     3                       2  2  3                       2  2      |             
      Renal Tubule, Hyperplasia            |                                                       4                  |             
      Transitional Epithelium, Hyperplasia |                   1                    2        1        1               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                 2                        |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Inflammation                         |       4                                                                  |      1  4.0|
      Ulcer                                |                                                       4                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Mineralization                       |                                                             1            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  A  +  +  A  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                  1                                       |      6  1.2|
      Clear Cell Focus                     |                            1                                             |      2  1.0|
      Degeneration, Cystic                 | 2     2              1  3                    2  2                    2   |     15  1.9|
      Degeneration                         |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                2                 1        2                              |      5  1.6|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis                             |       2                                3                                 |      2  2.5|
      Pigmentation                         |       1                                                                  |      1  1.0|
      Vacuolization Cytoplasmic            |          1                          2           1              3         |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                          +                             +   |   4        |
      Fat, Necrosis                        |             2                                                        2   |      3  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Oral Mucosa                             |                                                                      +   |   2        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1     2     2  2  1  2     1     1     2        3  2  2        2        2|     24  1.8|
      Acinus, Hyperplasia                  |          2                                                  2  2         |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia                          |             2     3                                                     3|      8  2.4|
      Inflammation                         |                                                                          |      1  3.0|
      Mineralization                       |                      2                                      4            |      2  3.0|
      Ulcer                                |             2     3                 4                                   3|      9  3.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  2.0|
      Mineralization                       |                      3                                      2            |      4  2.3|
      Necrosis                             |                                              2                          2|      5  1.8|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                      4                                      4            |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1        1     2     3  3  1     2        2  3  2           3  2     2  2|     26  1.9|
      Mineralization                       |                      2                                      2            |      2  2.0|
      Atrium, Thrombosis                   |       4                                            3                     |      5  3.2|
      Valve, Fibrosis                      |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |                   1                                                      |      1  1.0|
      Pigmentation                         |                                              2                           |      1  2.0|
      Vacuolization Cytoplasmic            |                         2     2                    2  3        2         |     13  1.9|
      Bilateral, Atrophy                   |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1     2                             2  2        2                  |     10  1.8|
      Bilateral, Hyperplasia               |                      2                                      2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Hyperplasia                          |                      4  3        2                    2     4        2   |     12  2.4|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                  3                 2  3                  |      5  3.0|
      Pars Distalis, Cyst                  |                               1                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |       3              1                 2  2        3        2           2|     12  2.2|
      Pars Distalis, Pigmentation          |                                                                          |      1  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          1                    1                    2           1         |      6  1.3|
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2                                                              3         |      2  2.5|
      Inflammation                         | 2  3     2              3     3     2     2     2     2  4        3      |     19  2.7|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |                         3        2                    2     1            |     11  2.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3     4           4              3           3              4            |     10  3.2|
      Hemorrhage                           |                                                                          |      1  2.0|
      Bilateral, Atrophy                   |                                     4                 2  3              2|      9  3.0|
      Interstitial Cell, Hyperplasia       |          1                    2        2                 2  2     2     2|     14  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                2     2                                      3            |      7  1.9|
      Myelofibrosis                        |                                                                          |      3  2.7|
      Myeloid Cell, Atrophy                |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +        +                                                            |   9        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  44        |
      Hemorrhage                           |       1              1                 4           1                     |      7  1.9|
      Pigmentation                         |                      1                                                   |      3  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Plasma Cell             |                2                                               2         |      4  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                             1            |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |       2                    3           4        1                        |     12  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                             3            |      2  3.0|
      Pigmentation                         |          1                       1              1           1            |      9  1.3|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                  2                                   3   |      3  2.7|
      Hematopoietic Cell Proliferation     |                      2                                      3            |      3  3.0|
      Necrosis                             |                                                                         3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|  46        |
      Galactocele                          |    2     2                       3  1                 4                  |     11  2.2|
      Hyperplasia                          | 2                                               2  2                     |      3  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                                                             2            |      1  2.0|
      Turbinate, Hyperostosis              |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |          2                                                               |      1  2.0|
      Necrosis                             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +  M  +  M|  40        |
      Infiltration Cellular, Lymphocyte    |                                                                3         |      1  3.0|
      Inflammation                         |                         1                                                |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                   2      |      1  2.0|
      Edema                                |       3                                                                  |      1  3.0|
      Infiltration Cellular, Histiocyte    |       2                                                                  |      2  2.5|
      Inflammation, Chronic                |                                                       1                  |      1  1.0|
      Inflammation, Chronic Active         |                      3                                      2            |      2  2.5|
      Inflammation, Granulomatous          | 2                                                                        |      1  2.0|
      Mineralization                       |                                                             2            |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         | 1                                                                        |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5|            |
                             DAY ON TEST   | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8|            |
                                           | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation                         |                         2        2  2     1                              |      8  2.1|
      Goblet Cell, Hyperplasia             | 2                                                                        |      2  2.0|
      Nasolacrimal Duct, Inflammation      |                               2                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |    1                 2  1        2  2           2        1     1         |      9  1.6|
      Respiratory Epithelium, Inflammation |                                                          1               |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
      Respiratory Epithelium, Ulcer        |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                         +|   1        |
      Lens, Cataract                       |                                                                         4|      1  4.0|
      Retina, Degeneration                 |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      2  2.0|
      Mineralization                       |                      1                                                   |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Nephropathy                          | 3     2  3  2  2  3  4  4  2  1  3  1  1  3  2  3  3  2  2  4  2     2  2|     47  2.3|
      Pigmentation                         |             2                                                           3|      9  2.3|
      Renal Tubule, Hyperplasia            |                                                             2            |      2  3.0|
      Transitional Epithelium, Hyperplasia | 1                    3  2        2        1     2  1        3            |     12  1.7|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hemorrhage                           |                         3                                                |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Inflammation                         |                   4                                                      |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                                                                    2   |             
      Necrosis                             |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  A  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                 1        1               |             
      Clear Cell Focus                     |                            2           1                                 |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |    2                       2           2                 2               |             
      Eosinophilic Focus                   |                            2           2                 2               |             
      Fibrosis                             |                      1                                   1               |             
      Hemorrhage                           |             1                                                        3   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Inflammation, Chronic Active         |                                                                3         |             
      Mixed Cell Focus                     |                                                          2               |             
      Necrosis                             |             1                                                  2  2  4   |             
      Vacuolization Cytoplasmic            |          1  1                          1                             2   |             
      Bile Duct, Inflammation, Suppurative |                                                                3         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                             +  +         |             
      Inflammation                         |                                                                4         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis                        |                                                             3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      4                                         4         |             
      Acinus, Atrophy                      |          1  1              3        2           2  3  1     2        2   |             
      Artery, Degeneration                 |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2     2            |             
      Inflammation                         |                      2                                                   |             
      Mineralization                       |                                                                          |             
      Ulcer                                | 1                                3                    3     2            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                         2|             
      Necrosis                             |                                                       1                  |             
      Ulcer                                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             2  1                       2  2        2     1     2  3  2   |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                   3                                   2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                            2                                             |             
      Degeneration, Cystic                 |                                     2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic            | 2                 1     2  1  2        2              2  1  2     2  1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2  2                          1           3      |             
      Bilateral, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                4                          3                 2            |             
      Pars Distalis, Cyst                  |    3  3        2                                               2         |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 1                 2                                         1            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                            2                                         2   |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                              3                           |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                                 |             
      Inflammation                         |          3                                                  3     3     2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Hyperplasia                          |                                     1                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |    3                 4  4  2  1  4  2  2     3  2  3  2  2        2  4  3|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      4   |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2  3           3|             
      Degeneration                         |                                                                          |             
      Arteriole, Inflammation              |                                                                          |             
      Bilateral, Atrophy                   |          3                                   3                    3      |             
      Interstitial Cell, Hyperplasia       |          1  1        1  1                 1  2  1     1     1     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                 3           3  2           3        2        4  4   |             
      Inflammation                         |                                                                3         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                  +                    +     +        +  +|             
      Lumbar, Hemorrhage                   |                                                                      3   |             
      Lumbar, Hyperplasia, Plasma Cell     |                                  4                                       |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  M  M  +  M  +  +  M  +  +  +  M  +  M  +  M  +  +  +  M  +|             
      Hemorrhage                           |                                                                   1      |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                            1           1                             4   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         2                                                |             
      Hemorrhage                           |                      3                    2                       1  4   |             
      Hyperplasia, Plasma Cell             |                                  2                                       |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                2                       2  1                              |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Depletion Cellular                   |                            2                                             |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 3                                               3                 3      |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                2                 2        3  2                    1     3|             
      Hyperplasia                          |                2                    2  2                                 |             
      Inflammation                         |                                                    2                     |             
      Pigmentation                         |                                                             2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |          X                                         3              3     X|             
      Inflammation, Granulomatous          |                                                    3                     |             
      Subcutaneous Tissue, Inflammation    |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Turbinate, Hyperostosis              | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |             2                             2                              |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                                 2                    4   |             
      Necrosis                             |                                                                      3   |             
      Respiratory Epithelium, Hyperplasia  |                                                             2            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |    1                                                                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                1                                                         |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |             
      Interstitium, Fibrosis               |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   2     2|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                               1     3                             2     2|             
      Glands, Cyst                         |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                                    2                     |             
      Respiratory Epithelium, Hyperplasia  |                                     2     1                             2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|             
                             DAY ON TEST   | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|             
                                           | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         2                                2               |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                1         |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  3     2  2  2  1     3  2     3  2  3  2  3  2  2  1  2        2  1  2|             
      Pigmentation                         |                                                       3     3            |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |    2                    2        3           1     2     1               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
      Inflammation                         |                                  3                                   2   |             
      Necrosis                             |                                                                      2   |             
      Transitional Epithelium, Hyperplasia |                                                                         2|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  4.0|
      Mineralization                       |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Inflammation                         |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +  A  +  +  +  +  +  +  A|  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                         1     1                                1         |      5  1.0|
      Clear Cell Focus                     |                               1                                          |      3  1.3|
      Cyst                                 |                                     3                                    |      1  3.0|
      Degeneration, Cystic                 | 1  1           1  2     2  1              1  2                           |     12  1.6|
      Eosinophilic Focus                   | 2                       2     2              2     1     2     2  2      |     11  1.9|
      Fibrosis                             |                         1                                                |      3  1.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      1     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                               2                                          |      2  2.0|
      Necrosis                             |                                                                          |      4  2.3|
      Vacuolization Cytoplasmic            |          1        1     1     1  4                                2      |     10  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Inflammation, Suppurative |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +           +                                         +                  |   5        |
      Inflammation                         |                                                                          |      1  4.0|
      Fat, Necrosis                        | 3           3                                         3                  |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      2  4.0|
      Acinus, Atrophy                      |       2     1  2     2        2        2  2  1  1           1  3  3      |     21  1.9|
      Artery, Degeneration                 |                   4                                                      |      1  4.0|
      Artery, Inflammation                 |                   3                                                      |      1  3.0|
      Artery, Mineralization               |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  3        2     2                        |      5  2.2|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                   3                                                      |      1  3.0|
      Ulcer                                |    3  3     3                    4        2                              |      9  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |             2                                                            |      1  2.0|
      Mineralization                       |                   3                          1              2            |      4  2.0|
      Necrosis                             |                                                 2                        |      2  1.5|
      Ulcer                                |                                           4                              |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                   4                          3                           |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2           2  2  3     3     2              3  2  2     2     2     2   |     21  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Mineralization                       |                   3                                                      |      1  3.0|
      Atrium, Thrombosis                   |       3                 4  3           3                 3               |      7  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                              2                           |      2  2.0|
      Vacuolization Cytoplasmic            |             3     2                 2        1  2           3  1         |     18  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           1     2                 1      |      7  1.7|
      Bilateral, Hyperplasia               |                                                          2  3            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3           2  2                                2                        |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |             3     4                          3              3  1         |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 3     2              3        2     2                 4  2  3            |     11  2.7|
      Pars Distalis, Cyst                  |       2                                                        1         |      6  2.2|
      Pars Distalis, Hemorrhage            | 3                                                                        |      1  3.0|
      Pars Distalis, Hyperplasia           | 2           3                 3     3              2     3     1  3      |     11  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                3         |      1  3.0|
      C-Cell, Hyperplasia                  |                            1  1           2                              |      5  1.6|
      Follicle, Cyst                       |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Inflammation                         |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              3                           |      2  3.0|
      Inflammation                         |       3                                                  2  4            |      7  2.9|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                    2                     |      1  2.0|
      Inflammation                         |    3  3     3  4     2           2     2  2        1  4        2  3     2|     29  2.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3                    2              4  2                           |      7  2.7|
      Degeneration                         |                                  1                                       |      1  1.0|
      Arteriole, Inflammation              |                   2                                                      |      1  2.0|
      Bilateral, Atrophy                   |          2  3                          3                                2|      7  2.7|
      Interstitial Cell, Hyperplasia       |             1  1  1        2     1  1  1        2                    1   |     19  1.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2           4     3           2                       3  4     3  3      |     16  2.9|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                +              +        +                                 |   8        |
      Lumbar, Hemorrhage                   |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  4.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
          Histiocyte                       |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  +  +  +|  34        |
      Hemorrhage                           |                   2              3                             1         |      4  1.8|
      Pigmentation                         |                   2              2                             1         |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Atrophy                              |                            3                                             |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            3                                             |      1  3.0|
      Hemorrhage                           |          2                                               3               |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           | 2     2           3           2  1                                      4|     10  2.4|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                         1                                                |      1  1.0|
      Pigmentation                         |       1     2     2           2              1                           |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  3.0|
      Depletion Cellular                   |             3                                                            |      2  2.5|
      Fibrosis                             |                                                    2                     |      1  2.0|
      Hematopoietic Cell Proliferation     |             3                                                            |      4  3.0|
      Pigmentation                         |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M|  44        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Galactocele                          |       2     2  2     3           2                                       |     11  2.2|
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation                         |                               2                                          |      2  2.0|
      Pigmentation                         |       2                       2                          2               |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      4  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation    |                                                          4               |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   3                                                      |      1  3.0|
      Turbinate, Hyperostosis              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      1                                                   |      1  1.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
      Necrosis                             |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M|  44        |
      Infiltration Cellular, Lymphocyte    |                                                          3               |      1  3.0|
      Inflammation                         |             2                                                            |      3  2.7|
      Necrosis                             |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |             2        2                                2                  |      4  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   3                          2                           |      2  2.5|
      Hemorrhage                           |                                              1                           |      2  1.0|
      Infiltration Cellular, Histiocyte    |       2                                                                  |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |          1              2                    1                           |      3  1.3|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mineralization                       |                   2                                                      |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                          1               |      2  1.5|
      Interstitium, Fibrosis               |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                    2                     |      1  2.0|
      Inflammation                         |       2        1     2                       2                           |      8  1.9|
      Glands, Cyst                         |                                                                   2      |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  | 1                    1                       1  2                        |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       3                                                     2            |      4  2.3|
      Hemorrhage                           |                                                    3                     |      1  3.0|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |                   3                                                      |      1  3.0|
      Nephropathy                          | 2  1  4  2  4  2  4  2  2  2  3  4     2  1  4  3  3  2  2  4  3  3  2   |     43  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3|            |
                             DAY ON TEST   | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5|            |
                                           | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Pigmentation                         |                2           1           3        3                        |      6  2.5|
      Renal Tubule, Hyperplasia            |                                                             2     2      |      2  2.0|
      Transitional Epithelium, Hyperplasia |       1     1  1  3           1        1     1                    1      |     14  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                              3                           |      2  2.5|
      Inflammation                         |                4                                                         |      3  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                3                                                         |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1                                                                     |             
      Basophilic Focus                     |                                        1                                 |             
      Clear Cell Focus                     |    1        2                                                            |             
      Degeneration, Cystic                 | 3                    2     1  2  2        2  1     1        1            |             
      Eosinophilic Focus                   |    2        2              2                                             |             
      Inflammation, Chronic                |                                                 2                        |             
      Thrombosis                           |                                                 2                        |             
      Vacuolization Cytoplasmic            |                                                       4              2   |             
      Kupffer Cell, Hyperplasia            |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Necrosis                        |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             
      Acinus, Atrophy                      | 1     1        1     2     2     2  3              1        1  1  3      |             
      Acinus, Hyperplasia                  |                                                    2                     |             
      Artery, Degeneration                 |                                                                      3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                      2   |             
      Hyperplasia                          |                3                          2                          2   |             
      Inflammation                         |                               2                 2                    2   |             
      Mineralization                       | 3                                                                        |             
      Ulcer                                |          3     3                          3           4                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                              3                           |             
      Inflammation                         |                                                 1                        |             
      Mineralization                       | 3                                            2                           |             
      Necrosis                             |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                                 1                        |             
      Aorta, Mineralization                | 2                                            3                           |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2        2  2     3     1     1  2              3  2              2   |             
      Inflammation                         |                                                 3                        |             
      Atrium, Thrombosis                   |          3     3  4                                      3     3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                            2                                             |             
      Degeneration                         |                                              2                           |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |          2                                                               |             
      Vacuolization Cytoplasmic            |          3     2                    1  3  2  3        3  3  1        2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                      2     2        1  2        2        2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Bilateral, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2                 2                                             |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 3              1  1  2  1              2  4  3  2                    2   |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    1        4            |             
      Pars Distalis, Cyst                  |             1              1           1           2                     |             
      Pars Distalis, Degeneration          |                                                 3                        |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2           2  2  2        2  2        2     1     2           2         |             
      Pars Distalis, Necrosis              |                                                 2                        |             
      Pars Distalis, Pigmentation          |                                                 3                 2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2                 1                                            1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |       3                                                                  |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         |                1                                2        4           2  2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
      Inflammation                         |    2  2  4  3  3        1           3  2  4     2     3              2   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2              3     2                                               2   |             
      Arteriole, Inflammation              |                                                             1            |             
      Bilateral, Atrophy                   |                   3                       2  3                    3      |             
      Bilateral, Necrosis                  |          4                                                               |             
      Interstitial Cell, Hyperplasia       |       1                 2                 1     2     1     1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 4                        |             
      Hemorrhage                           |                      2                          4                        |             
      Hyperplasia                          | 3     3  3  2                 2        3     2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +           +           +        +        +     +     +|             
      Hemorrhage                           |                               2                                          |             
      Pancreatic, Fibrosis                 |                   4                                                      |             
      Pancreatic, Pigmentation             |                   3                                                      |             
      Renal, Ectasia                       |                               3                             2            |             
      Renal, Hemorrhage                    |                                                             1            |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           | 2                                   2        2                           |             
      Infiltration Cellular, Histiocyte    |                                              2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
      Hemorrhage                           |                                              1                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Inflammation                         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 3  1        1  1                                2                        |             
      Inflammation                         |                                                 3                        |             
      Pigmentation                         |       2     1  2              2     1                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                             2            |             
      Fibrosis                             |    2                 1           2                                       |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Inflammation, Chronic                |                                                 2                        |             
      Red Pulp, Depletion Cellular         |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
      Fibrosis                             |                                              2                           |             
      Galactocele                          |       2        2              3           2           3     4            |             
      Hyperplasia                          |                      3                 2                                 |             
      Inflammation                         |                                                                   3      |             
      Pigmentation                         |                   3                          2                           |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Epidermis, Hyperplasia               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 3                    1                       2                           |             
      Hyperostosis                         |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                           3                    2  2      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M|             
      Foreign Body                         |             2                                                            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |             3                                   3                        |             
      Respiratory Epithelium, Hyperplasia  |    2                                                                     |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 1                                                                        |             
      Foreign Body                         |                                                 2                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                              2                           |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2                                               3                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Foreign Body                         |                                                          1               |             
      Inflammation                         | 1     3           2                          2           3           2   |             
      Goblet Cell, Hyperplasia             |                                                 2                        |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                   1        1                 1           2           2   |             
      Respiratory Epithelium, Ulcer        |                                                          1               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|             
                                           | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              2                           |             
      Mineralization                       |                                              2                           |             
      Nephropathy                          | 4  2  1  2  2  2  2  4     2  3  2  2  3  4  4  3  2  2  3  3  1  1  4  2|             
      Pigmentation                         |                3        3                                      3  3      |             
      Renal Tubule, Hyperplasia            |                      1              1  1                                 |             
      Transitional Epithelium, Hyperplasia | 3           1        2     1     1     1  2  1              1            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             
      Transitional Epithelium, Hyperplasia |                                     1                                    |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Thrombosis                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |                                                                         1|      2  1.0|
      Clear Cell Focus                     |                                                                2         |      3  1.7|
      Degeneration, Cystic                 |    2              2  1  3  2           2     3        1           2     1|     19  1.8|
      Eosinophilic Focus                   |                                                                         2|      4  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |             4     2              2              2  3                     |      7  2.7|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                        +                                +|   3        |
      Fat, Necrosis                        |                                        2                                 |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 3     3              2     2              2           2     2  2  2      |     20  1.9|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Artery, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia                          | 2           2                                   3           2     3      |      8  2.4|
      Inflammation                         |                                                                          |      3  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |             4                                2  3  4              3      |      9  3.2|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation                         |             2                    2                                       |      3  1.7|
      Mineralization                       |                                              2                           |      3  2.3|
      Necrosis                             |                                                             2            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation                  |                                                                          |      1  1.0|
      Aorta, Mineralization                |                            3                 2                           |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                            2     2                    2        2         |     15  2.1|
      Inflammation                         |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                      3  3                                                |      7  3.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                         2|      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1     2     1  3                                   3              2      |     16  2.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1        2     2        2  2                 2        2                  |     13  1.8|
      Bilateral, Hyperplasia               |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      3                                                   |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Fibrosis                             |                                              3                           |      1  3.0|
      Hyperplasia                          | 2           2              4              1  4                 2         |     16  2.3|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                   4                                2  4                  |      5  3.0|
      Pars Distalis, Cyst                  |                                           2                              |      5  1.4|
      Pars Distalis, Degeneration          |                                                                          |      1  3.0|
      Pars Distalis, Hemorrhage            |                                                                         2|      1  2.0|
      Pars Distalis, Hyperplasia           |       2        2                                                         |     12  1.9|
      Pars Distalis, Necrosis              |                                                                          |      1  2.0|
      Pars Distalis, Pigmentation          |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1                                                                       2|      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Inflammation                         |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                      4   |      1  4.0|
      Inflammation                         |                               2        2        2                        |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |    2           2  2  4  2     2     2  2  3                    1         |     22  2.4|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3              2  3  3                 2     2                  |     10  2.4|
      Arteriole, Inflammation              |                                                                          |      1  1.0|
      Bilateral, Atrophy                   |                                                                      3   |      5  2.8|
      Bilateral, Necrosis                  |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       | 1           1        2        2  1                          1            |     12  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia                          |                            2                                            3|      9  2.6|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                      +                                 |   9        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pancreatic, Fibrosis                 |                                                                          |      1  4.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
      Renal, Ectasia                       |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Hyperplasia, Plasma Cell      | 2                                                                        |      1  2.0|
      Renal, Pigmentation                  | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  M  M  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  M  +|  39        |
      Ectasia                              | 2                                                                        |      1  2.0|
      Hemorrhage                           |                                                                1         |      4  1.8|
      Infiltration Cellular, Histiocyte    | 2                                                                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Plasma Cell             | 2                                                                        |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |             1              3                       2                     |      4  1.8|
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             1                    2                 1           2        2|     10  1.6|
      Inflammation                         |                                                                          |      1  3.0|
      Pigmentation                         |                                  1                    1                  |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |    2                                                           2         |      3  2.0|
      Fibrosis                             |                                              2                           |      4  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Red Pulp, Depletion Cellular         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Mammary Gland                           | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Fibrosis                             |                                                                          |      1  2.0|
      Galactocele                          | 3           1        2                          2           3            |     11  2.5|
      Hyperplasia                          |                2                                               2         |      4  2.3|
      Inflammation                         |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                           X                              |      2     |
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                            2                 2                           |      5  2.0|
      Hyperostosis                         |                                           4                              |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                 3                        |      1  3.0|
      Mineralization                       |                1                                                         |      1  1.0|
      Necrosis                             |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                   +     +|   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                   +  +  +|   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +|  41        |
      Foreign Body                         |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                              2                           |      1  2.0|
      Inflammation                         |             1                                                            |      3  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                1         |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      1  2.0|
      Goblet Cell, Hyperplasia             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         3                                                |      1  3.0|
      Foreign Body                         |                      2                                                   |      2  1.5|
      Inflammation                         |                      2                 2        2                        |      9  2.1|
      Goblet Cell, Hyperplasia             |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                    2                     |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                      1                 2  1     1                        |      9  1.3|
      Respiratory Epithelium, Ulcer        |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8|            |
                                           | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 2  2  1  1  4  2  2  1  2  4  1        1  2  4  2  3  2  2  2  3  2  1  3|     47  2.3|
      Pigmentation                         |       1        2     2  2                                         2      |      9  2.3|
      Renal Tubule, Hyperplasia            |                                                                2         |      4  1.3|
      Transitional Epithelium, Hyperplasia |                2     2     2  1                       1        2         |     15  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +|             
      Inflammation                         |                                     2                                    |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  A  A  A  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  A  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +|             
      Inflammation                         |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       1                                               1                  |             
      Degeneration, Cystic                 | 2  1  1  2  2              2  2  2     2  2  2  1  2  2  2  1     2  1  1|             
      Eosinophilic Focus                   |       1     2  1     2                                1           2      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mineralization                       |                                                       2                  |             
      Necrosis                             |             2        1        2     2                             1      |             
      Vacuolization Cytoplasmic            |                   4                                                      |             
      Bile Duct, Hyperplasia               |                                                                         2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                    +                                          |             
      Fat, Necrosis                        |          3                    3                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     4                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Atrophy                      | 2           1              2     2     2        2  2  2  1  1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  2     2           2  2                       3               |             
      Inflammation                         |          1  2                             2                              |             
      Mineralization                       |                                        2                                 |             
      Ulcer                                |                   3                                3  4  4  3            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2                                                                        |             
      Inflammation                         |                                                                          |             
      Mineralization                       |          2     3        2              2        2  2  3           2  4  2|             
      Ulcer                                |                   2                                         3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Aorta, Inflammation                  | 2                                                                        |             
      Aorta, Mineralization                | 3              3                       3        3                 3  3  3|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  2  2  3     3  2        2     3  2     3  2           2  3  2   |             
      Mineralization                       |          1     2     2                                3              2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                            2                                             |             
      Necrosis                             |                                     4                                    |             
      Vacuolization Cytoplasmic            |          2              1                    2           3        2     1|             
      Capsule, Inflammation                |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |          1                                            1  1        1     2|             
      Necrosis                             |                                     4                                    |             
      Bilateral, Hyperplasia               |                                        2                       2     2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3     3  2  4     1  2     1  4     3        2  3  4  2     2  3  4  2|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Angiectasis           |    3        2                       1                 4                  |             
      Pars Distalis, Cyst                  |                                                                         2|             
      Pars Distalis, Hyperplasia           | 2  2        2     1     2  2     2                 2  2     3           2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 2              4              2           3           2           2     4|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2     3     1  2  2  3     2     2     2        2  4  2  3     4         |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                 3              3                    1           2  4   |             
      Degeneration                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Mineralization                       |                2                                                     2   |             
      Bilateral, Atrophy                   |                               3                          3              2|             
      Interstitial Cell, Hyperplasia       |                               1           1              1     1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Hemorrhage                           |                                                                2         |             
      Hyperplasia                          |       2        2  3           3  2  4  2                 2        2  2   |             
      Myelofibrosis                        |                                                    2  2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                       +           +  +     +     +  +           +|             
      Renal, Ectasia                       |       3                                                                  |             
      Renal, Hemorrhage                    |       2                       1                    3     4               |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                               2                                          |             
      Renal, Pigmentation                  |       2                       2                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  M  +  +  M  M  M  +  +  +  M  +  M  M  +  M  M  M  +|             
      Hemorrhage                           |          3              2                                                |             
      Pigmentation                         | 2        2  1                                      1                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                     3  2                       2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                    2                 2     2               |             
      Inflammation                         |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2                                                            |             
      Hemorrhage                           |                                  2     2           4  3           2      |             
      Infiltration Cellular, Histiocyte    |                   2                                                      |             
      Pigmentation                         | 2           1                                                     1      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Atrophy                              |                                                                          |             
      Depletion Cellular                   | 2                                                     2        3         |             
      Fibrosis                             |             2                                                            |             
      Hematopoietic Cell Proliferation     |                                     2  2                                 |             
      Necrosis                             |                                                             4     2      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |          2                    1                       1        1  3      |             
      Hyperplasia                          |       2                                                                  |             
      Mineralization                       |                                                                      2   |             
      Pigmentation                         |                2        2                                               3|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                        2                                 |             
      Inflammation                         |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2  1                                   2              2           2  3  3|             
      Turbinate, Hyperostosis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  M  +  M  +  +  +  M  +  +  M  +  M  +  +  +  +  +  M  M  +  +  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |    1                                                                     |             
      Respiratory Epithelium, Hyperplasia  |                                                                   2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                           2         |             
      Edema                                |    3                                   2                       1         |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                        1                          2      |             
      Inflammation, Acute                  |                         2                                                |             
      Inflammation, Chronic                |                      2                                         1         |             
      Inflammation, Chronic Active         | 1                                      3                             1   |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1     2                                                         |             
      Artery, Mineralization               |                                                                          |             
      Interstitium, Inflammation           |                2                                                         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation                         |                                                                3  1      |             
      Necrosis                             |                                                                3         |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2                                            1  1                        |             
      Respiratory Epithelium, Inflammation |                                        2        1                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|             
                                           | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                                                 3  3   |             
      Infarct                              |                                           3                              |             
      Mineralization                       |                      2  2              2        2                    2  3|             
      Necrosis                             |                                     4                                    |             
      Nephropathy                          | 4  4  3  4  4  4  4  4  4  3  2  4     4  3  2  4  4  4  4  2  3  4  4  4|             
      Pigmentation                         |                                                                          |             
      Renal Tubule, Hyperplasia            |          2     2        2  2                                   1  2      |             
      Transitional Epithelium, Hyperplasia | 2  2  2  2  2     1     2  1  1  2           2  2  2  2  2        2  2  1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  A  +  A  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  39        |
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  A  A  +  +  A  +  A  +  A  +  +  +  A  +  +  A  +  +  +  A  +  +  +|  34        |
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  A  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  +  +  +|  37        |
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                  1                                       |      1  1.0|
      Basophilic Focus                     |                                  2        1                              |      4  1.3|
      Degeneration, Cystic                 | 1     3           2           2  2     2                 2  2     3  1  1|     30  1.8|
      Eosinophilic Focus                   |                   2                 4  1                                 |      9  1.8|
      Hepatodiaphragmatic Nodule           |                                                       X                  |      1     |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             | 2                                      2                 3               |      8  1.9|
      Vacuolization Cytoplasmic            |                                  2  1                 1                  |      4  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   3        |
      Fat, Necrosis                        |                                  2                                       |      3  2.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Oral Mucosa                             |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|
      Acinus, Atrophy                      |    2        2                                      2     1  2  2  2     2|     18  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                            2                           |      8  2.1|
      Inflammation                         |                                                                          |      3  1.7|
      Mineralization                       |    3                    2              2  2                              |      5  2.2|
      Ulcer                                | 2                          2     4              3                    2   |     10  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Inflammation                         |                                  2                                       |      1  2.0|
      Mineralization                       |    2              2     3              3  2              3        2     3|     18  2.4|
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    3                                                                     |      1  3.0|
      Aorta, Inflammation                  |                                                                          |      1  2.0|
      Aorta, Mineralization                |                   3     2              2  2              3        3     4|     14  2.9|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  3  1           2     3     2  2     1  1  3           3  2     2     3|     30  2.2|
      Mineralization                       |    2                                                     3               |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Degeneration, Cystic                 |             3     2                          1                           |      3  2.0|
      Hyperplasia                          |                      2              1                                    |      2  1.5|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                2         |      2  3.0|
      Vacuolization Cytoplasmic            |                      2     3        1           2                       1|     11  1.8|
      Capsule, Inflammation                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                         2                                         1     2|      8  1.4|
      Necrosis                             |                                                                          |      1  4.0|
      Bilateral, Hyperplasia               |                2                                                         |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          | 3  3  3     2  2  3     4  3        3  4  4     3        4  3     3  2  4|     35  2.9|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Angiectasis           |                                                                          |      4  2.5|
      Pars Distalis, Cyst                  |             3  1        2                                                |      4  2.0|
      Pars Distalis, Hyperplasia           |             3                                                            |     12  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |             4                             2                              |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                              2                           |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                   2      |      1  2.0|
      Inflammation                         |                                                       3  4        4      |     10  3.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    2              3        4  2  3        2  1  3     3  3     4         |     25  2.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      6  2.7|
      Degeneration                         |                                                                2         |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Bilateral, Atrophy                   |             3                                                            |      4  2.8|
      Interstitial Cell, Hyperplasia       |    1     1                 2                                   1         |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hemorrhage                           |                   3                    3                          1      |      4  2.3|
      Hyperplasia                          |             2        3     2     1              2        3  2        4  2|     19  2.4|
      Myelofibrosis                        |                         2                                         2     2|      5  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +              +     +                    +                 +        +   |  14        |
      Renal, Ectasia                       |                                                                          |      1  3.0|
      Renal, Hemorrhage                    | 2                    2                    3                 2            |      8  2.4|
      Renal, Hyperplasia, Lymphoid         |                                                             2            |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  +  +  M  M  M  M  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +|  28        |
      Hemorrhage                           |                               1        2                    2  3        1|      7  2.0|
      Pigmentation                         |                                                             1            |      5  1.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                          1               |      1  1.0|
      Hyperplasia, Plasma Cell             |                                                                      2   |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   2                 1        3                    1      |      8  1.9|
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |                   2                                            2         |      3  2.0|
      Hemorrhage                           |             2     2  3              1  1  3              2  4  2  2  1  2|     17  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Pigmentation                         |                      1              1           1           1            |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                    3                                                |      2  3.0|
      Depletion Cellular                   |             3                                                            |      4  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Cyst                                 |    2                                                                     |      1  2.0|
      Hemorrhage                           |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                   2        3        1                 1                  |      9  1.7|
      Hyperplasia                          |                                     1     2                              |      3  1.7|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         |                2                                2        2               |      6  2.2|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                           2              3               |      9  2.2|
      Turbinate, Hyperostosis              |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  M  +  +  +  M  +|  35        |
      Infiltration Cellular, Lymphocyte    |                               2                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                             2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    3  3                       3                             3            |      6  2.8|
      Edema                                |    3  2                                                                 2|      6  2.2|
      Fibrosis                             |                                                                   2      |      1  2.0|
      Hemorrhage                           |                         2     2                          2  3     2     2|      8  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |    2           2                                                  2     1|      7  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Mineralization                       |    1                                                              1     1|      3  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Artery, Mineralization               |                         2                                                |      1  2.0|
      Interstitium, Inflammation           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                             4            |      1  4.0|
      Foreign Body                         |                                                             1            |      1  1.0|
      Inflammation                         |             1     2     2              2  2                 1        3   |      9  1.9|
      Necrosis                             |                                                                          |      1  3.0|
      Olfactory Epithelium, Inflammation   |                                                 1                        |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                 2                        |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |          2  1                                                        2   |      6  1.5|
      Respiratory Epithelium, Inflammation |                                                                1         |      3  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                     +                                    |   1        |
      Cyst                                 |                                     4                                    |      1  4.0|
      Hyperplasia                          |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    2        3                          2  3     3        2        3      |     10  2.7|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |    2                                                     2              2|      9  2.1|
      Necrosis                             |                                                                          |      1  4.0|
      Nephropathy                          | 4  4  4     4  3  4  3  4  3  2  3  4  4  4  4  4  2  2  4  3  2  4  2  4|     48  3.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 05210-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            ETHYLBENZENE                                       Date: 01/27/05    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5|            |
                             DAY ON TEST   | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3|            |
                                           | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    750                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Pigmentation                         |                2                                               3         |      2  2.5|
      Renal Tubule, Hyperplasia            |       1     1        1           2              2                 3      |     12  1.8|
      Transitional Epithelium, Hyperplasia | 2  2  2     2  1  2  2  2  1        2  2        2  1     3        1     2|     34  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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