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TDMS Study 05211-05 Pathology Tables


NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01
Route: DOSED FEED                                                                                                 Time: 12:57:56

                                                       FINAL#3;REVISION#1




       Facility:  Southern Research Institute

       Chemical CAS #:  518-82-1

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            8           11           15                                     
    Natural Death                                      5            3            4            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           39           35           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (48)         (50)         (49)         (50)                                   
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
   Pancreas                                           (49)         (50)         (49)         (50)                                   
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                               1 (2%)                                
   Adrenal Medulla                                    (47)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          1 (2%)                    4 (8%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Pars Distalis, Adenoma                          15 (31%)     21 (42%)     25 (51%)     25 (51%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Intermedia, Adenoma                         1 (2%)                                 1 (2%)                                
      Pars Intermedia, Carcinoma                                    1 (2%)                                                          
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  4 (8%)       5 (10%)      4 (8%)       3 (6%)                                
      C-Cell, Carcinoma                                2 (4%)       2 (4%)                    3 (6%)                                
      Follicular Cell, Adenoma                                      1 (2%)                    1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (49)         (49)                                   
      Adenoma                                         10 (20%)     10 (20%)      8 (16%)      9 (18%)                               
      Carcinoma                                        2 (4%)       3 (6%)       2 (4%)                                             
      Bilateral, Adenoma                                            2 (4%)                    1 (2%)                                
   Ovary                                              (49)         (50)         (50)         (50)                                   
      Bilateral, Granulosa Cell Tumor Benign                        1 (2%)                                                          
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                   10 (20%)      7 (14%)      7 (14%)     10 (20%)                               
      Polyp Stromal, Multiple                                       1 (2%)                                                          
      Sarcoma Stromal                                  1 (2%)                                                                       
   Vagina                                             (2)          (3)          (3)          (5)                                    
      Granular Cell Tumor Benign                                                 1 (33%)                                            
      Squamous Cell Papilloma                                                    1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
   Lymph Node                                         (5)          (3)          (4)          (3)                                    
   Lymph Node, Mandibular                             (49)         (50)         (50)         (50)                                   
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Thymus                                             (47)         (49)         (49)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Thymoma Benign                                   1 (2%)                    1 (2%)                                             
      Thymoma Malignant                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)         (50)                                   
      Carcinoma                                                                               2 (4%)                                
      Fibroadenoma                                    18 (37%)     13 (26%)     20 (40%)     16 (32%)                               
      Fibroadenoma, Multiple                           5 (10%)      5 (10%)                   1 (2%)                                
   Skin                                               (49)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                  1 (2%)                                                                       
      Schwannoma Malignant                             1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Glioma Malignant                                                           1 (2%)                                             
      Granular Cell Tumor Malignant                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Adrenal Cortex                                                   1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Lacrimal Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
   Zymbal's Gland                                                                            (3)                                    
      Carcinoma                                                                               3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (49)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            14 (28%)     17 (34%)     16 (32%)      3 (6%)                                
      Mesothelioma Malignant                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          47          48          43                                       
     Total Primary Neoplasms                           94          99          98          85                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          39          41          37                                       
     Total Benign Neoplasms                            70          70          75          70                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          24          22          15                                       
     Total Malignant Neoplasms                         24          29          23          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1           2                                       
     Total Metastatic Neoplasm                          2           1           1           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           26           27           16                                     
    Natural Death                                      3            3            2            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           21           21           30                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (50)         (50)         (49)                                   
   Intestine Small, Duodenum                          (48)         (50)         (49)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (48)         (50)         (49)                                   
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Intestine Small, Ileum                             (50)         (50)         (48)         (49)                                   
      Sarcoma                                                                                 1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                                                      1 (2%)                                
      Fibrosarcoma, Metastatic, Spleen                                           1 (2%)                                             
      Hepatocellular Carcinoma                                      3 (6%)       3 (6%)                                             
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Mesentery                                          (8)          (7)          (13)         (15)                                   
      Sarcoma                                                                                 2 (13%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                                           1 (2%)                                             
      Mixed Tumor Benign                               2 (4%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Schwannoma Malignant                                                       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (49)         (48)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (49)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                          6 (12%)     11 (22%)      5 (10%)      9 (18%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)       2 (4%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          2 (4%)       5 (10%)      1 (2%)       1 (2%)                                
      Carcinoma                                        3 (6%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (48)         (45)         (45)         (47)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (48)         (50)                                   
      Pars Distalis, Adenoma                          15 (31%)      9 (18%)     10 (21%)     13 (26%)                               
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  3 (6%)       5 (10%)      3 (6%)       3 (6%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
      Follicular Cell, Carcinoma                                    2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)          (1)          (3)          (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          5 (10%)      1 (2%)       2 (4%)       3 (6%)                                
      Carcinoma                                        3 (6%)       2 (4%)       1 (2%)       3 (6%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)       3 (6%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     30 (60%)     37 (74%)     35 (70%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Interstitial Cell, Adenoma                       7 (14%)     13 (26%)      7 (14%)     13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Lymph Node                                         (12)         (21)         (18)         (11)                                   
   Lymph Node, Mandibular                             (49)         (50)         (48)         (50)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Thymus                                             (46)         (47)         (48)         (48)                                   
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (47)         (49)         (49)                                   
      Fibroadenoma                                     1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
   Skin                                               (50)         (50)         (49)         (49)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                                          1 (2%)                    1 (2%)                                
      Keratoacanthoma                                  3 (6%)       3 (6%)       3 (6%)       3 (6%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                    2 (4%)                                
      Trichoepithelioma                                1 (2%)                                 1 (2%)                                
      Sebaceous Gland, Adenoma                         1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (6%)       2 (4%)       5 (10%)                               
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiopericytoma          1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                               1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (1)                                    (2)                                    
      Schwannoma Malignant, Metastatic, Skin                                                  1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            2 (4%)       1 (2%)                                                          
      Oligodendroglioma Malignant                                   1 (2%)                                                          
      Pineal Gland, Meningioma Malignant                            1 (2%)                                                          
   Spinal Cord                                        (2)          (5)          (8)          (3)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 2 (4%)                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                       (1)                                    
      Carcinoma                                                     1 (100%)                  1 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Renal Tubule, Stromal Nephroma                                1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
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         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leukemia Mononuclear                            28 (56%)     31 (62%)     29 (58%)     18 (36%)                               
      Mesothelioma Malignant                           2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01  
Route: DOSED FEED                                                                                                 Time: 12:57:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          131         141         124         133                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          46          47          49                                       
     Total Benign Neoplasms                            87          91          79          98                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          38          36          28                                       
     Total Malignant Neoplasms                         44          50          45          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1           2                                       
     Total Metastatic Neoplasm                                                  2           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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