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TDMS Study 05211-06 Pathology Tables

NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98
Route: DOSED FEED                                                                                                 Time: 10:33:41

                                                        CORE STUDY MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  518-82-1

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            9            2            7                                     
    Natural Death                                      6            2            7            7                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           39           40           36                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (49)         (48)         (48)                                   
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
   Intestine Large, Rectum                            (47)         (49)         (48)         (47)                                   
   Intestine Large, Cecum                             (47)         (49)         (47)         (45)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Jejunum                           (45)         (48)         (45)         (46)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Ileum                             (48)         (49)         (47)         (46)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatocellular Carcinoma                         3 (6%)       6 (12%)      8 (16%)      1 (2%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Hepatocellular Adenoma                           8 (16%)      6 (12%)     10 (20%)      7 (14%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       4 (8%)       2 (4%)                                
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
   Mesentery                                          (14)         (16)         (15)         (11)                                   
      Hemangiosarcoma                                  1 (7%)                    1 (7%)       1 (9%)                                
      Histiocytic Sarcoma                              1 (7%)       2 (13%)      1 (7%)       1 (9%)                                
      Leiomyosarcoma, Metastatic, Uterus               1 (7%)                                                                       
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                                            1 (9%)                                
      Sarcoma                                          1 (7%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (7%)                                                                       
   Pancreas                                           (48)         (49)         (49)         (48)                                   
      Acinus, Adenoma                                               1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (48)         (49)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (50)         (49)         (48)         (48)                                   
   Tooth                                                                        (2)                                                 
      Adamantinoma Malignant                                                     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Rhabdomyosarcoma                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Capsule, Adenoma                                                                        1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Pituitary Gland                                    (46)         (45)         (46)         (44)                                   
      Pars Distalis, Adenoma                           4 (9%)       4 (9%)       9 (20%)      8 (18%)                               
      Pars Intermedia, Adenoma                                                                1 (2%)                                
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (48)                                   
      C-Cell, Adenoma                                                            1 (2%)                                             
      Follicular Cell, Adenoma                         2 (4%)       5 (10%)      2 (4%)       2 (4%)                                
      Follicular Cell, Adenoma, Multiple                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)                                                                           
      Sarcoma, Metastatic, Mesentery                   1 (50%)                                                                      
   Tissue NOS                                         (2)          (3)                       (1)                                    
      Abdominal, Leiomyosarcoma, Metastatic,                                                                                        
          Intestine Small, Jejunum                                                            1 (100%)                              
      Abdominal, Rhabdomyosarcoma, Metastatic,                                                                                      
           Heart                                                    1 (33%)                                                         
      Abdominal, Schwannoma Malignant                               1 (33%)                                                         
      Pelvic, Fibrosarcoma                             1 (50%)                                                                      
      Thoracic, Rhabdomyosarcoma                       1 (50%)      1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (44)         (48)         (48)                                   
      Cystadenoma                                      1 (2%)       2 (5%)       2 (4%)       1 (2%)                                
      Histiocytic Sarcoma                                           2 (5%)                                                          
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
      Luteoma                                                                                 1 (2%)                                
   Oviduct                                            (1)          (1)                       (1)                                    
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                   1 (2%)                                                                       
      Endometrium, Polyp Stromal                       2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
   Vagina                                                          (1)                                                              
      Histiocytic Sarcoma                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node                                         (8)          (7)          (9)          (7)                                    
      Histiocytic Sarcoma                                           1 (14%)                                                         
      Axillary, Histiocytic Sarcoma                                 1 (14%)                                                         
      Bronchial, Histiocytic Sarcoma                                1 (14%)                                                         
      Deep Cervical, Histiocytic Sarcoma                            1 (14%)                                                         
      Iliac, Histiocytic Sarcoma                                    1 (14%)      2 (22%)                                            
      Inguinal, Histiocytic Sarcoma                                 1 (14%)                                                         
      Mediastinal, Histiocytic Sarcoma                              1 (14%)      1 (11%)      1 (14%)                               
      Mediastinal, Leiomyosarcoma, Metastatic,                                                                                      
           Uterus                                      1 (13%)                                                                      
      Mediastinal, Sarcoma, Metastatic, Peritoneum     1 (13%)                                                                      
      Pancreatic, Histiocytic Sarcoma                               1 (14%)      1 (11%)                                            
      Popliteal, Histiocytic Sarcoma                                1 (14%)                                                         
      Renal, Histiocytic Sarcoma                                                 1 (11%)      1 (14%)                               
   Lymph Node, Mandibular                             (48)         (46)         (47)         (47)                                   
      Histiocytic Sarcoma                                           2 (4%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (48)         (50)         (49)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       4 (8%)       1 (2%)                                
      Rhabdomyosarcoma, Metastatic, Heart                           1 (2%)                                                          
   Spleen                                             (48)         (49)         (49)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)       1 (2%)                                
   Thymus                                             (49)         (49)         (46)         (48)                                   
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (49)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Myoepithelioma                                   1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Sebaceous Gland, Carcinoma                       1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Rhabdomyosarcoma,                                                                                        
          Metastatic, Heart                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                               1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (2)                       (2)          (3)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (33%)                               
      Hemangiosarcoma                                                                         1 (33%)                               
      Leiomyosarcoma, Metastatic, Uterus               1 (50%)                                                                      
      Rhabdomyosarcoma                                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                    3 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                    1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       2 (4%)                                
      Rhabdomyosarcoma, Metastatic, Heart                           1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Tissue NOS                  1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (2%)                                                                       
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (2%)                                
      Mediastinum, Histiocytic Sarcoma                                           1 (2%)       2 (4%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Pleura                                             (1)                                                                           
      Sarcoma, Metastatic, Mesentery                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (4)          (3)                                    
      Adenoma                                                       3 (100%)     3 (75%)      1 (33%)                               
      Carcinoma                                        1 (100%)                               2 (67%)                               
      Bilateral, Carcinoma                                                       1 (25%)                                            
   Zymbal's Gland                                                  (1)          (1)                                                 
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)       2 (4%)       1 (2%)                                
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (49)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       5 (10%)      3 (6%)                                
      Lymphoma Malignant                               9 (18%)     10 (20%)      8 (16%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   6                                                               
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34          33          43          37                                       
     Total Primary Neoplasms                           54          52          64          59                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          23          25          19                                       
     Total Benign Neoplasms                            25          27          34          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          22          25          25                                       
     Total Malignant Neoplasms                         29          25          30          33                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2                       4                                       
     Total Metastatic Neoplasm                         12           5                       6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            7            4                                                  
    Moribund Sacrifice                                 4            6            6            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           37           40           43                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (46)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (49)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Duodenum                          (47)         (49)         (50)         (50)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (46)         (49)         (50)                                   
      Carcinoma                                                                  4 (8%)                                             
      Leiomyosarcoma                                   1 (2%)                    1 (2%)                                             
   Intestine Small, Ileum                             (48)         (49)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)                    1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatoblastoma                                   1 (2%)                                                                       
      Hepatocellular Carcinoma                        13 (26%)     15 (30%)     17 (34%)     12 (24%)                               
      Hepatocellular Carcinoma, Multiple               7 (14%)     10 (20%)      5 (10%)      4 (8%)                                
      Hepatocellular Adenoma                           7 (14%)      5 (10%)      5 (10%)      7 (14%)                               
      Hepatocellular Adenoma, Multiple                 2 (4%)       5 (10%)      7 (14%)      4 (8%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (2%)                                             
   Mesentery                                          (2)          (4)          (6)          (5)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (25%)                                                         
      Carcinoma, Metastatic, Pancreas                                                         1 (20%)                               
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (17%)      1 (20%)                               
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (17%)                                            
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
           Jejunum                                                               1 (2%)                                             
      Duct, Carcinoma                                                                         1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Capsule, Adenoma                                 1 (2%)       5 (10%)      4 (8%)       2 (4%)                                
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
   Parathyroid Gland                                  (44)         (47)         (46)         (45)                                   
      Carcinoma                                                                               1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)       4 (8%)                                                          
      Follicular Cell, Adenoma, Multiple                            1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
   Lymph Node                                         (6)          (3)          (4)          (1)                                    
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (33%)                                                         
      Pancreatic, Hepatocellular Carcinoma,                                                                                         
          Metastatic, Liver                            1 (17%)                                                                      
   Lymph Node, Mandibular                             (49)         (49)         (50)         (48)                                   
   Lymph Node, Mesenteric                             (49)         (46)         (50)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
   Thymus                                             (42)         (45)         (46)         (39)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Pinna, Fibrosarcoma                              1 (2%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Hepatocellular                                                                                           
          Carcinoma, Metastatic, Liver                                           1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (3)          (1)          (2)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (33%)                                                         
      Carcinoma, Metastatic, Pancreas                                                         1 (50%)                               
      Hemangiosarcoma, Metastatic, Liver                                                      1 (50%)                               
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     9 (18%)      9 (18%)      5 (10%)      7 (14%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   9 (18%)      6 (12%)      6 (12%)      5 (10%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       3 (6%)                                                          
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       3 (6%)       5 (10%)      3 (6%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                     1 (2%)                                                                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
      Mediastinum, Leiomyosarcoma, Metastatic,                                                                                      
           Intestine Small, Jejunum                    1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      External Ear, Histiocytic Sarcoma                             1 (100%)                                                        
   Harderian Gland                                    (4)          (3)          (4)          (7)                                    
      Adenoma                                          4 (100%)     2 (67%)      3 (75%)      4 (57%)                               
      Carcinoma                                                     1 (33%)      1 (25%)      3 (43%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Renal Tubule, Adenoma                                         1 (2%)       1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)       1 (2%)                                
   Urethra                                                         (1)                                                              
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant                               5 (10%)      3 (6%)       3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  11                                                               
NTP Experiment-Test: 05211-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:33:41  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          46          43          37                                       
     Total Primary Neoplasms                           74          76          71          56                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          27          24          22                                       
     Total Benign Neoplasms                            29          36          30          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          33          32          26                                       
     Total Malignant Neoplasms                         45          40          41          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           6           5                                       
     Total Metastatic Neoplasm                          5          11          11          10                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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