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TDMS Study 05211-07 Pathology Tables

NTP Experiment-Test: 05211-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99
Route: DOSED FEED                                                                                                 Time: 10:50:55

                                                   53 WEEK SPECIAL STUDY RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  518-82-1

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05211-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:50:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                           5            5            5            5                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            5            5            5                                     

  Animals Examined Microscopically                     5            5            5            5                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (5)          (5)          (5)          (5)                                    
      Basophilic Focus                                 4 (80%)      1 (20%)      2 (40%)      4 (80%)                               
      Infiltration Cellular, Mixed Cell                             1 (20%)      1 (20%)      1 (20%)                               
      Bile Duct, Hyperplasia                           1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:50:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)          (5)          (5)                                    
      Nephropathy                                      3 (60%)      3 (60%)      4 (80%)      4 (80%)                               
      Renal Tubule, Hyaline Droplet                    3 (60%)      5 (100%)     5 (100%)     5 (100%)                              
      Renal Tubule, Pigmentation                       5 (100%)     5 (100%)     5 (100%)     5 (100%)                              
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:50:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                           5            5            5            5                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            5            5            5                                     

  Animals Examined Microscopically                     5            5            5            5                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (5)          (5)          (5)          (5)                                    
      Basophilic Focus                                 1 (20%)                   1 (20%)      1 (20%)                               
      Infiltration Cellular, Mixed Cell                2 (40%)                   1 (20%)      1 (20%)                               
      Mixed Cell Focus                                                                        1 (20%)                               
      Bile Duct, Hyperplasia                           1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:50:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)          (5)          (5)                                    
      Inflammation, Chronic                            1 (20%)                                1 (20%)                               
      Nephropathy                                      5 (100%)     5 (100%)     5 (100%)     5 (100%)                              
      Renal Tubule, Hyaline Droplet                                 5 (100%)     5 (100%)     5 (100%)                              
      Renal Tubule, Pigmentation                       5 (100%)     5 (100%)     5 (100%)     4 (80%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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                             ----------              END OF REPORT             ----------                                           
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