Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4667

TDMS Study 05212-03 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/18/94   
EXP: 05212                        OXAZEPAM                     TIME: 10:10:23   
TEST: 03              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 62453    
CONT: N01-ES-85213                                             CAS: 604-75-1    
PATHOLOGIST: R. PERSING                                                         
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/18/94  
EXP: 05212                        OXAZEPAM                     TIME: 10:10:23  
TEST: 03              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 62453   
CONT: N01-ES-85213                                             CAS: 604-75-1   
PATHOLOGIST: R. PERSING                                                        

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 5      CENSORED DEATHS 10   TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      117   586   624   627   707                                               |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 125 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 6      CENSORED DEATHS 10   TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      453   508   527   625   701   715                                         |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 35     CENSORED DEATHS 10   TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      486   523   540   567   594   598   608   615   616   628                 |
 |      638   639   642   645   646   665   666   667   669   673                 |
 |      673   679   679   682   697   700   703   710   714   720                 |
 |      720   720   722   722   727                                               |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 ==================================================================================

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 50     CENSORED DEATHS 10   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      401   413   434   450   451   461   464   479   479   507                 |
 |      514   531   535   537   539   542   547   566   567   567                 |
 |      568   569   569   569   575   575   587   589   593   595                 |
 |      596   596   596   598   609   612   614   615   617   617                 |
 |      622   622   623   623   624   624   625   625   628   628                 |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 ==================================================================================

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0  98.3  98.3  98.3  98.3  98.3  98.3  96.3  92.3  90.3      |
 |           |                                                                    |
 |           |                                                                    |
 |125 PPM    |   100.0 100.0 100.0 100.0 100.0  98.3  94.3  94.3  92.3  88.3      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  88.0  68.0  30.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |   100.0 100.0 100.0 100.0  96.7  83.5  69.3  32.6   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        125 PPM      2500 PPM     5000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       90.3%        88.3%        30.0%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.987      P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       532.2        588.2        654.1        561.7    |
 |NATURAL DEATHS (C)      |       ( 106)       (44.2)       (10.2)       ( 8.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       667.8        670.1        640.5        544.8    |
 |(STANDARD ERROR)        |       (16.1)       (14.0)       (12.7)       ( 8.9)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      357   516   576   598   622   624   630   638   652   659                 |
 |      670                                                                       |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 125 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 9      CENSORED DEATHS 10   TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      391   471   490   492   649   662   701   714   732                       |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 48     CENSORED DEATHS 10   TERMINAL 2         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      393   396   470   575   596   614   615   622   630   634                 |
 |      635   636   638   642   644   645   648   663   664   665                 |
 |      666   667   677   689   691   692   699   700   701   702                 |
 |      706   706   710   711   711   712   712   712   712   712                 |
 |      719   719   719   719   719   719   719   719                             |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 ==================================================================================

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 50     CENSORED DEATHS 10   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      6     7     7     403   410   412   414   415   450   454                 |
 |      457   470   471   478   479   491   494   499   504   526                 |
 |      533   535   541   547   554   562   563   566   567   568                 |
 |      569   569   570   570   577   582   583   589   594   595                 |
 |      596   596   600   612   613   614   614   617   617   617                 |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 ==================================================================================

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.3  98.3  98.3  96.3  92.3  80.3  78.3      |
 |           |                                                                    |
 |           |                                                                    |
 |125 PPM    |   100.0 100.0 100.0 100.0  98.3  96.3  92.3  92.3  88.3  82.3      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0 100.0 100.0 100.0  96.7  94.7  94.7  90.6  60.4   4.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |    95.0  95.0  95.0  95.0  86.7  73.3  56.5  14.7   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        125 PPM      2500 PPM     5000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.3%        82.3%         4.0%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.761N     P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       594.7        589.1        661.8        505.5    |
 |NATURAL DEATHS (C)      |       (27.1)       (42.5)       (10.8)       (20.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       663.5        667.3        630.6        498.0    |
 |(STANDARD ERROR)        |       (14.5)       (15.1)       (13.2)       (16.9)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                              OXAZEPAM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        125 PPM          = 2
                                                        2500 PPM         = 3
                                                        5000 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                  1                                            4       2    3
      |                    1                                            44  4   2    3  2  32       1      1
      |                                                                     4   4          32 3  3         2
      |                                                                         44               3    3    1           1
   90 +                                                                          44                   33               1 2  1
      |                                                                           4 4                  33                2  2
      |                                                                                                 33
      |                                                                             4   44               3 3
   80 +                                                                                  4  4              3 3
      |                                                                                     44
      |                                                                                                      33
      |                                                                                      44
P  70 +                                                                                       44              3  3
E     |                                                                                        4 4               33
R     |
C     |                                                                                                           33
E  60 +                                                                                          44
N     |
T     |                                                                                                            33
      |                                                                                           44                3 3
S  50 +                                                                                            44
U     |                                                                                             4 4               33
R     |                                                                                                                33
V     |                                                                                                                 33
I  40 +                                                                                               44
V     |
A     |                                                                                                                  33
L     |                                                                                                44
   30 +                                                                                                 44                3 3
      |
      |                                                                                                  44
      |
   20 +
      |
      |
      |                                                                                                   44
   10 +
      |
      |
      |
    0 +                                                                                                    4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.

                                                              OXAZEPAM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        125 PPM          = 2
                                                        2500 PPM         = 3
                                                        5000 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 14                                                      1     23
      |                                                         1     23           2 2   1         1
      |  4                                                              4          3 22            1   1
      |                                                                 44            2            3   1  1   2
   90 +                                                                  44                            3 311  2  2
      |                                                                   4     4                        331 1   2     22
      |                                                                                                   33 1 1        2   2
      |                                                                         44 4                       33  1 1          2
   80 +                                                                                                          11
      |                                                                            44                       33    1         1
      |
      |                                                                             4 4
P  70 +                                                                               44                     33
E     |                                                                                                       3  3
R     |                                                                                4    4
C     |                                                                                     44
E  60 +                                                                                                          33
N     |                                                                                      444                  33
T     |                                                                                        44                  3 3
      |                                                                                         44
S  50 +
U     |                                                                                                              33
R     |                                                                                          44                   33
V     |
I  40 +
V     |                                                                                                                33
A     |
L     |                                                                                           444
   30 +
      |                                                                                             4 4
      |
      |
   20 +                                                                                               44                33
      |
      |                                                                                                4 4
      |
   10 +
      |                                                                                                  44
      |                                                                                                                  3  3
      |
    0 +                                                                                                   4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 12 obs hidden.