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TDMS Study 05214-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL


NTP Experiment-Test: 05214-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: GAVAGE                                                                                                     Time: 12:55:03




       Facility:  TSI Mason Research

       Chemical CAS #:  1972-08-3

       Lock Date:  06/01/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10            5           13           14                                     
    Moribund Sacrifice                                 3            5            3            3                                     
    Accidently Killed                                                                         1                                     
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           50           44           41                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (59)                                   
      Perforation                                                                             1 (2%)                                
      Periesophageal Tissue, Inflammation, Subacute                                           1 (2%)                                
   Gallbladder                                        (53)         (59)         (54)         (54)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Epithelium, Ulcer, Chronic Active                             1 (2%)                                                          
   Intestine Large, Colon                             (57)         (60)         (58)         (57)                                   
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Intestine Large, Cecum                             (57)         (60)         (58)         (57)                                   
      Atrophy                                          1 (2%)                                                                       
   Intestine Small, Duodenum                          (57)         (60)         (57)         (54)                                   
      Dysplasia                                                     1 (2%)                                                          
   Intestine Small, Jejunum                           (57)         (60)         (57)         (55)                                   
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Liver                                              (60)         (60)         (59)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Basophilic Focus                                              2 (3%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                 1 (2%)       3 (5%)                                                          
      Congestion                                                                              1 (2%)                                
      Eosinophilic Focus                               9 (15%)                   1 (2%)       1 (2%)                                
      Fatty Change                                    13 (22%)      3 (5%)                    2 (3%)                                
      Hematopoietic Cell Proliferation                 6 (10%)      2 (3%)       2 (3%)       3 (5%)                                
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)       2 (3%)                                                          
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Mixed Cell Focus                                 2 (3%)       1 (2%)       2 (3%)                                             
      Necrosis                                         2 (3%)                                 1 (2%)                                
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Central Vein, Dilatation                                                   1 (2%)                                             
      Centrilobular, Fibrosis                                                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (11)         (1)          (1)          (3)                                    
      Inflammation, Chronic                                                                   2 (67%)                               
      Inflammation, Chronic Active                                  1 (100%)                                                        
      Fat, Necrosis                                    9 (82%)                   1 (100%)                                           
   Pancreas                                           (59)         (60)         (59)         (57)                                   
      Atrophy                                          1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Chronic                            4 (7%)       5 (8%)       3 (5%)       3 (5%)                                
      Arteriole, Infiltration Cellular, Lymphocyte     2 (3%)                                                                       
      Arteriole, Inflammation, Chronic                 1 (2%)                                                                       
      Duct, Ectasia                                    1 (2%)       2 (3%)                    3 (5%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy                                          2 (3%)                                 1 (2%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Stomach, Forestomach                               (58)         (60)         (58)         (57)                                   
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Squamous                           15 (26%)     11 (18%)     10 (17%)      9 (16%)                               
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Ulcer                                            2 (3%)       4 (7%)       6 (10%)      4 (7%)                                
   Stomach, Glandular                                 (58)         (60)         (58)         (57)                                   
      Dysplasia                                                                               1 (2%)                                
      Erosion                                          3 (5%)                    1 (2%)                                             
      Hyperplasia                                      3 (5%)                                 1 (2%)                                
      Mineralization                                   1 (2%)                    2 (3%)                                             
      Ulcer                                            1 (2%)                                                                       
      Glands, Dilatation                               1 (2%)                                                                       
   Tooth                                              (3)          (1)                       (3)                                    
      Abscess                                          1 (33%)                                1 (33%)                               
      Dysplasia                                        2 (67%)      1 (100%)                  2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                   6 (10%)      4 (7%)       5 (8%)       1 (2%)                                
      Degeneration                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)                    1 (2%)                                
      Atrium, Thrombosis                                                         1 (2%)                                             
      Epicardium, Inflammation, Acute                                                         1 (2%)                                
      Valve, Bacterium                                                           3 (5%)                                             
      Valve, Degeneration                              1 (2%)                                                                       
      Valve, Inflammation, Chronic                                               3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       3 (5%)       2 (3%)                                                          
      Capsule, Hyperplasia                            57 (97%)     60 (100%)    59 (98%)     57 (95%)                               
      Capsule, Inflammation, Chronic                   1 (2%)       1 (2%)                                                          
      Zona Reticularis, Hemorrhage                                               1 (2%)                                             
      Zona Reticularis, Necrosis                                                              1 (2%)                                
   Adrenal Medulla                                    (59)         (60)         (60)         (60)                                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
   Islets, Pancreatic                                 (59)         (60)         (59)         (56)                                   
      Hyperplasia                                     29 (49%)     33 (55%)     19 (32%)      9 (16%)                               
   Parathyroid Gland                                  (49)         (54)         (49)         (51)                                   
      Cyst                                             1 (2%)       1 (2%)       4 (8%)                                             
   Pituitary Gland                                    (55)         (58)         (58)         (57)                                   
      Pars Distalis, Cyst                              3 (5%)       2 (3%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                      25 (45%)     19 (33%)     10 (17%)      8 (14%)                               
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Lymphocyte                             3 (5%)       2 (3%)                                             
      Infiltration Cellular, Polymorphonuclear                                                1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Follicular Cell, Hyperplasia                    28 (47%)     46 (77%)     40 (67%)     33 (55%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (59)         (56)         (54)                                   
      Abscess                                                                    1 (2%)       1 (2%)                                
      Atrophy                                          1 (2%)                                                                       
      Dilatation                                                    3 (5%)                                                          
      Hyperplasia, Squamous                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
   Ovary                                              (59)         (59)         (60)         (59)                                   
      Abscess                                          2 (3%)       2 (3%)                    1 (2%)                                
      Angiectasis                                      2 (3%)                    1 (2%)                                             
      Cyst                                             3 (5%)       1 (2%)       2 (3%)       6 (10%)                               
      Hemorrhage                                       2 (3%)       1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                                 1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            1 (2%)       2 (3%)                    1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Periovarian Tissue, Cyst                         3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
      Periovarian Tissue, Inflammation, Chronic                                               1 (2%)                                
      Periovarian Tissue, Necrosis                     1 (2%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Dilatation                                      10 (17%)      4 (7%)       5 (8%)       7 (12%)                               
      Inflammation, Acute                              2 (3%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Endometrium, Atrophy                             1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                52 (87%)     53 (88%)     52 (87%)     39 (65%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Myelofibrosis                                   35 (59%)     40 (67%)     31 (52%)     23 (38%)                               
      Proliferation                                    2 (3%)       1 (2%)                                                          
   Lymph Node                                         (6)          (3)          (1)          (2)                                    
      Bronchial, Amyloid Deposition                                                           1 (50%)                               
      Lumbar, Cyst                                     1 (17%)                                                                      
      Pancreatic, Hyperplasia, Lymphoid                             1 (33%)                                                         
   Lymph Node, Mandibular                             (56)         (59)         (59)         (57)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            6 (11%)      2 (3%)                    2 (4%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Lymph Node, Mesenteric                             (57)         (60)         (57)         (53)                                   
      Angiectasis                                      1 (2%)       2 (3%)       1 (2%)       2 (4%)                                
      Atrophy                                                                    1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia, Lymphoid                            3 (5%)       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Spleen                                             (59)         (60)         (60)         (59)                                   
      Angiectasis                                      1 (2%)                                                                       
      Lymphoid Follicle, Atrophy                       9 (15%)      1 (2%)       2 (3%)       4 (7%)                                
      Lymphoid Follicle, Hyperplasia, Lymphoid        30 (51%)     18 (30%)     17 (28%)     19 (32%)                               
      Red Pulp, Hematopoietic Cell Proliferation      53 (90%)     37 (62%)     28 (47%)     23 (39%)                               
   Thymus                                             (59)         (58)         (56)         (58)                                   
      Abscess                                                                                 1 (2%)                                
      Cyst                                             6 (10%)      9 (16%)      6 (11%)      8 (14%)                               
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (59)         (60)         (59)                                   
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Abscess                                                       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Degeneration                                     6 (10%)      3 (5%)       3 (5%)       3 (5%)                                
      Infiltration Cellular, Lymphocyte                7 (12%)      1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)         (60)                                   
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                  32 (53%)     27 (45%)     25 (43%)     23 (38%)                               
      Hippocampus, Neuron, Necrosis                                 1 (2%)                                                          
   Peripheral Nerve                                   (60)         (60)         (60)         (59)                                   
      Degeneration                                     1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                    2 (3%)                                
      Perineural, Inflammation, Chronic                1 (2%)                                                                       
   Spinal Cord                                        (60)         (60)         (60)         (59)                                   
      Meninges, Inflammation, Acute                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)         (60)         (60)                                   
      Abscess                                                                                 1 (2%)                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                       3 (5%)       8 (13%)      2 (3%)       8 (13%)                               
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (3%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte                   1 (2%)                    1 (2%)                                
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
   Nose                                               (59)         (60)         (60)         (60)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Acute                              4 (7%)       5 (8%)       6 (10%)      1 (2%)                                
      Inflammation, Chronic                           24 (41%)     22 (37%)     19 (32%)     18 (30%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Lumen, Exudate                                   2 (3%)                                                                       
      Nasolacrimal Duct, Hyperplasia                   2 (3%)                    1 (2%)                                             
      Olfactory Epithelium, Hyperplasia                1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
      Respiratory Epithelium, Hyperplasia              1 (2%)                                                                       
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                                                              
      Middle Ear, Inflammation, Chronic Active                      1 (100%)                                                        
      Mucosa, Middle Ear, Hyperplasia                               1 (100%)                                                        
   Eye                                                                                       (1)                                    
      Cornea, Inflammation, Chronic                                                           1 (100%)                              
      Lens, Cataract                                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)                                
      Metaplasia, Osseous                                           1 (2%)                                                          
      Mineralization                                  27 (45%)     17 (28%)      6 (10%)      3 (5%)                                
      Nephropathy                                     39 (65%)     22 (37%)     15 (25%)     38 (63%)                               
      Glomerulus, Amyloid Deposition                   1 (2%)                                                                       
      Pelvis, Inflammation, Chronic                                              1 (2%)       1 (2%)                                
      Renal Tubule, Bacterium                                                                 1 (2%)                                
      Renal Tubule, Degeneration, Hyaline              1 (2%)                                                                       
      Renal Tubule, Necrosis                           2 (3%)                                 2 (3%)                                
   Urinary Bladder                                    (59)         (60)         (60)         (59)                                   
      Dilatation                                       1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                             3 (5%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)       2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)       2 (3%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           60           70           70                                     
  Scheduled Sacrifice                                 18                         9           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9            5           11           21                                     
    Moribund Sacrifice                                 3            2            3            4                                     
    Accidently Killed                                                            2                                                  
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                50           53           45           33                                     
    Natural Death                                                                             1                                     
  Animals Examined Microscopically                    80           60           70           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (62)         (60)         (61)         (59)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Subacute                                                                  1 (2%)                                
      Perforation                                                                             1 (2%)                                
   Gallbladder                                        (57)         (56)         (54)         (53)                                   
      Dilatation                                                                              2 (4%)                                
   Intestine Large, Cecum                             (60)         (57)         (56)         (55)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid                        1 (2%)       3 (5%)                                             
   Intestine Small, Duodenum                          (60)         (57)         (54)         (54)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Ileum                             (60)         (57)         (54)         (54)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid           1 (2%)                                 1 (2%)                                
   Liver                                              (62)         (60)         (61)         (57)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Basophilic Focus                                 2 (3%)       2 (3%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                 7 (11%)      1 (2%)                                                          
      Eosinophilic Focus                              18 (29%)      1 (2%)                                                          
      Fatty Change                                    20 (32%)     11 (18%)      1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          2 (3%)                                                                       
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                         4 (7%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mixed Cell Focus                                              1 (2%)       2 (3%)       1 (2%)                                
      Necrosis                                         2 (3%)                                 2 (4%)                                
      Regeneration                                     1 (2%)                                                                       
      Bile Duct, Dilatation                                                      1 (2%)                                             
   Mesentery                                          (7)          (1)          (1)          (2)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                                                            1 (50%)                               
      Fat, Necrosis                                    6 (86%)                                                                      
   Pancreas                                           (62)         (59)         (61)         (57)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)       2 (3%)       1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Arteriole, Inflammation, Chronic                                           1 (2%)                                             
      Arteriole, Mineralization                                                  1 (2%)                                             
      Duct, Hyperplasia                                1 (2%)                                                                       
   Salivary Glands                                    (62)         (60)         (61)         (58)                                   
      Duct, Dilatation                                              1 (2%)                                                          
   Stomach, Forestomach                               (62)         (58)         (58)         (56)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Squamous                            7 (11%)     33 (57%)     38 (66%)     18 (32%)                               
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Ulcer                                            5 (8%)      17 (29%)     14 (24%)      8 (14%)                               
   Stomach, Glandular                                 (62)         (58)         (57)         (56)                                   
      Edema                                                                                   1 (2%)                                
      Erosion                                          3 (5%)       1 (2%)                    1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (3%)       2 (4%)       3 (5%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
   Tongue                                             (1)          (3)          (3)                                                 
      Dysplasia                                                                  1 (33%)                                            
      Epithelium, Hyperplasia, Squamous                1 (100%)                                                                     
   Tooth                                              (48)         (48)         (43)         (23)                                   
      Abscess                                          3 (6%)       2 (4%)                    2 (9%)                                
      Dysplasia                                       46 (96%)     47 (98%)     42 (98%)     23 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (62)         (60)         (61)         (60)                                   
      Bacterium                                                     1 (2%)                                                          
      Cardiomyopathy                                   6 (10%)      9 (15%)      6 (10%)      6 (10%)                               
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)       3 (5%)                                
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Atrium, Thrombosis                                                         1 (2%)                                             
      Endothelium, Hyperplasia                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (62)         (59)         (61)         (59)                                   
      Focal Cellular Change                                                                   1 (2%)                                
      Hyperplasia                                     14 (23%)      8 (14%)      5 (8%)       1 (2%)                                
      Hypertrophy                                     10 (16%)      6 (10%)      7 (11%)      3 (5%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Capsule, Hyperplasia                            52 (84%)     50 (85%)     51 (84%)     45 (76%)                               
      Capsule, Inflammation, Chronic Active                                                   1 (2%)                                
   Adrenal Medulla                                    (61)         (59)         (61)         (58)                                   
      Hyperplasia                                                                             1 (2%)                                
   Islets, Pancreatic                                 (62)         (59)         (61)         (55)                                   
      Hyperplasia                                     41 (66%)     27 (46%)     17 (28%)      6 (11%)                               
   Parathyroid Gland                                  (50)         (47)         (50)         (49)                                   
      Cyst                                                          5 (11%)                   1 (2%)                                
   Pituitary Gland                                    (59)         (57)         (59)         (53)                                   
      Pars Distalis, Cyst                              2 (3%)       4 (7%)       4 (7%)       2 (4%)                                
      Pars Distalis, Hyperplasia                       9 (15%)      2 (4%)       1 (2%)       4 (8%)                                
   Thyroid Gland                                      (62)         (60)         (61)         (57)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Follicle, Cyst                                                1 (2%)                                                          
      Follicular Cell, Hyperplasia                    16 (26%)     48 (80%)     45 (74%)     27 (47%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Abscess                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (60)         (70)         (69)                                   
      Granuloma Sperm                                  1 (1%)       2 (3%)       1 (1%)                                             
      Inflammation, Chronic                            1 (1%)                                                                       
   Preputial Gland                                    (62)         (59)         (60)         (59)                                   
      Abscess                                          1 (2%)       1 (2%)       1 (2%)                                             
      Atrophy                                         46 (74%)     37 (63%)     25 (42%)     17 (29%)                               
      Dilatation                                       3 (5%)                    1 (2%)                                             
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
      Inflammation, Chronic                           36 (58%)     43 (73%)     35 (58%)     23 (39%)                               
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
   Prostate                                           (62)         (60)         (62)         (60)                                   
      Abscess                                                                    1 (2%)       1 (2%)                                
      Concretion                                       4 (6%)       1 (2%)                    7 (12%)                               
      Congestion                                                                              1 (2%)                                
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
      Inflammation, Acute                                                        2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         1 (2%)                    3 (5%)                                
      Inflammation, Chronic Active                                                            2 (3%)                                
   Seminal Vesicle                                    (62)         (60)         (62)         (57)                                   
      Dilatation                                       7 (11%)      1 (2%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                                             2 (4%)                                
   Testes                                             (80)         (60)         (70)         (69)                                   
      Atrophy                                          1 (1%)                                                                       
      Degeneration                                     3 (4%)                                                                       
      Granuloma Sperm                                  1 (1%)                    1 (1%)                                             
      Inflammation, Chronic                            1 (1%)                                                                       
      Mineralization                                   1 (1%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (62)         (60)         (60)         (58)                                   
      Hyperplasia, Megakaryocyte                       1 (2%)                                                                       
      Myelofibrosis                                                              1 (2%)                                             
      Proliferation                                    8 (13%)      4 (7%)       5 (8%)       6 (10%)                               
      Myeloid Cell, Proliferation                                                             1 (2%)                                
   Lymph Node, Mandibular                             (54)         (50)         (54)         (53)                                   
      Atrophy                                                                    3 (6%)       1 (2%)                                
      Congestion                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)                                                          
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (59)         (55)         (57)         (54)                                   
      Angiectasis                                      5 (8%)       2 (4%)                    2 (4%)                                
      Atrophy                                          3 (5%)       1 (2%)       5 (9%)       1 (2%)                                
      Congestion                                       1 (2%)                                                                       
      Ectasia                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 3 (5%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
   Spleen                                             (62)         (59)         (61)         (59)                                   
      Angiectasis                                      1 (2%)                                                                       
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
      Lymphoid Follicle, Atrophy                       4 (6%)       1 (2%)       2 (3%)       7 (12%)                               
      Lymphoid Follicle, Hyperplasia, Lymphoid        17 (27%)     20 (34%)     11 (18%)      5 (8%)                                
      Red Pulp, Atrophy                                                                       1 (2%)                                
      Red Pulp, Hematopoietic Cell Proliferation      33 (53%)     14 (24%)     17 (28%)     13 (22%)                               
   Thymus                                             (58)         (50)         (55)         (52)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            17 (29%)     12 (24%)      6 (11%)      4 (8%)                                
      Ectopic Parathyroid Gland                                                               1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Chronic                                                                   1 (2%)                                
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (62)         (60)         (61)         (61)                                   
      Abscess                                                       1 (2%)       1 (2%)                                             
      Acanthosis                                                    1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Abscess                                                            1 (2%)                                
      Subcutaneous Tissue, Foreign Body                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (62)         (60)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Skeletal Muscle                                    (62)         (60)         (61)         (60)                                   
      Degeneration                                    10 (16%)      7 (12%)      8 (13%)      7 (12%)                               
      Infiltration Cellular, Lymphocyte                1 (2%)       3 (5%)       2 (3%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (62)         (60)         (61)         (59)                                   
      Mineralization                                  42 (68%)     33 (55%)     28 (46%)     23 (39%)                               
      Cerebrum, Neuron, Necrosis                       1 (2%)                                                                       
      Thalamus, Neuron, Necrosis                       1 (2%)                                                                       
   Peripheral Nerve                                   (60)         (60)         (61)         (60)                                   
      Degeneration                                     2 (3%)                                                                       
   Spinal Cord                                        (62)         (60)         (61)         (59)                                   
      Degeneration                                                               1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (62)         (60)         (61)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Edema                                            2 (3%)                                                                       
      Hemorrhage                                       3 (5%)       4 (7%)       6 (10%)      6 (10%)                               
      Inflammation, Chronic                            2 (3%)                    2 (3%)       3 (5%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Leukocytosis                                                  1 (2%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)       1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte      5 (8%)                                 2 (3%)                                
      Bronchiole, Hyperplasia                          1 (2%)       2 (3%)                                                          
   Nose                                               (62)         (59)         (61)         (58)                                   
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                           26 (42%)     23 (39%)     14 (23%)     13 (22%)                               
      Glands, Hyperplasia, Glandular                                                          1 (2%)                                
      Lumen, Foreign Body                              2 (3%)                                                                       
      Nasolacrimal Duct, Hyperplasia                   1 (2%)       2 (3%)                    3 (5%)                                
      Nasolacrimal Duct, Inflammation, Chronic         2 (3%)                                                                       
      Olfactory Epithelium, Hyperplasia                4 (6%)       1 (2%)       3 (5%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)          (1)                                    
      Cataract                                                                   1 (100%)                                           
      Phthisis Bulbi                                                1 (100%)                                                        
      Cornea, Fibrosis                                 1 (100%)                                                                     
   Harderian Gland                                    (2)          (4)          (5)          (2)                                    
      Hyperplasia                                                   1 (25%)                   2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (62)         (60)         (61)         (60)                                   
      Bacterium                                                     2 (3%)       2 (3%)       1 (2%)                                
      Cyst                                            12 (19%)      2 (3%)       3 (5%)       7 (12%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hydronephrosis                                                                          1 (2%)                                
      Inflammation, Chronic Active                                  2 (3%)       3 (5%)       6 (10%)                               
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                  55 (89%)     56 (93%)     45 (74%)     32 (53%)                               
      Nephropathy                                     61 (98%)     50 (83%)     43 (70%)     42 (70%)                               
      Pelvis, Inflammation, Chronic                    1 (2%)       2 (3%)       5 (8%)      12 (20%)                               
      Pelvis, Transitional Epithelium, Hyperplasia                               1 (2%)                                             
      Renal Tubule, Bacterium                                                    1 (2%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Pigmentation                       1 (2%)                                                                       
   Urinary Bladder                                    (62)         (60)         (62)         (58)                                   
      Dilatation                                       6 (10%)      1 (2%)       2 (3%)       7 (12%)                               
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic                                                      4 (6%)       9 (16%)                               
      Transitional Epithelium, Bacterium                                         1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05214-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                       2 (3%)       8 (14%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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