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https://ntp.niehs.nih.gov/go/4723

TDMS Study 05217-05 Pathology Tables

NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 08:56:45




       Facility:  Southern Research Institute

       Chemical CAS #:  1948-33-0

       Lock Date:  08/04/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                  9            8            9            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            7            6            6                                     
    Natural Death                                      2           10            5            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           35           40           42                                     
    Natural Death                                      1                                      1                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (58)         (56)         (60)                                   
      Cyst                                                                       1 (2%)                                             
   Intestine Small, Duodenum                          (60)         (59)         (57)         (59)                                   
      Erosion                                          1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (59)         (57)         (59)                                   
      Perforation, Chronic                                                       1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Intestine Small, Ileum                             (60)         (59)         (56)         (59)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)       1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      2 (3%)                                 1 (2%)                                
      Basophilic Focus                                 2 (3%)       1 (2%)       1 (2%)                                             
      Clear Cell Focus                                                           2 (3%)       2 (3%)                                
      Eosinophilic Focus                               4 (7%)       9 (15%)      9 (15%)     11 (18%)                               
      Eosinophilic Focus, Multiple                     3 (5%)       5 (8%)       1 (2%)       1 (2%)                                
      Fatty Change                                     4 (7%)       1 (2%)                                                          
      Fatty Change, Focal                              2 (3%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
      Hemorrhage, Focal                                                                       1 (2%)                                
      Hyperplasia, Focal, Lymphoid                                                            1 (2%)                                
      Infarct                                          1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Mixed Cell                2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Inflammation, Focal                              3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
      Mineralization, Focal                                                      1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       4 (7%)       2 (3%)       1 (2%)                                
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
      Necrosis, Focal                                  1 (2%)       1 (2%)                    2 (3%)                                
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                          1 (2%)                    1 (2%)       1 (2%)                                
   Mesentery                                          (10)         (13)         (7)          (9)                                    
      Hemorrhage                                                    1 (8%)                                                          
      Inflammation, Chronic                            1 (10%)      1 (8%)       3 (43%)      4 (44%)                               
      Fat, Necrosis                                    8 (80%)      5 (38%)      1 (14%)      2 (22%)                               
   Pancreas                                           (60)         (60)         (58)         (60)                                   
      Atrophy, Focal                                   1 (2%)       1 (2%)       2 (3%)                                             
      Duct, Cyst                                       1 (2%)                                                                       
   Salivary Glands                                    (60)         (60)         (60)         (58)                                   
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Erosion                                          3 (5%)                    1 (2%)                                             
      Inflammation, Chronic                            5 (8%)                    1 (2%)       3 (5%)                                
      Pigmentation, Focal                                                                     1 (2%)                                
      Ulcer                                            1 (2%)                                 2 (3%)                                
      Epithelium, Hyperplasia                          5 (8%)                    1 (2%)       4 (7%)                                
   Stomach, Glandular                                 (60)         (60)         (58)         (60)                                   
      Erosion                                          1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Pigmentation, Focal                                           1 (2%)                                                          
      Ulcer                                                                                   1 (2%)                                
      Glands, Degeneration, Cystic, Focal                                        1 (2%)                                             
   Tooth                                                           (2)          (4)          (1)                                    
      Incisor, Dysplasia                                            2 (100%)     4 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (59)         (60)         (60)         (60)                                   
      Mesenteric Artery, Inflammation, Chronic                                   1 (2%)                                             
   Heart                                              (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation, Chronic                                              2 (3%)                                             
      Myocardium, Mineralization, Focal                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (59)         (60)                                   
      Accessory Adrenal Cortical Nodule                2 (3%)       4 (7%)       1 (2%)       1 (2%)                                
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Capsule, Hyperplasia                             1 (2%)                                                                       
      Subcapsular, Hyperplasia, Focal                                                         2 (3%)                                
   Adrenal Medulla                                    (60)         (59)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)                                 4 (7%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (60)         (60)         (57)         (60)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (55)         (56)         (58)         (55)                                   
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (58)         (52)         (55)         (55)                                   
      Angiectasis                                      2 (3%)                    2 (4%)       1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Cytoplasmic Alteration, Focal     2 (3%)       3 (6%)       2 (4%)       1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                3 (5%)       3 (6%)       2 (4%)       1 (2%)                                
      Pars Intermedia, Hyperplasia, Focal                           1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (59)         (60)                                   
      Degeneration, Cystic, Focal                      1 (2%)                                 1 (2%)                                
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                                 2 (3%)                                
      C-Cell, Hyperplasia                              2 (3%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia                    12 (20%)     19 (32%)     24 (41%)     24 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (59)         (60)                                   
      Degeneration, Cystic                                          4 (7%)       2 (3%)       3 (5%)                                
   Ovary                                              (59)         (57)         (56)         (56)                                   
      Angiectasis                                      2 (3%)       2 (4%)                    3 (5%)                                
      Cyst                                            19 (32%)     10 (18%)     11 (20%)     12 (21%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Tubular                                                                    1 (2%)                                
      Inflammation, Suppurative                        2 (3%)       2 (4%)       2 (4%)       5 (9%)                                
      Thrombosis                                                                              1 (2%)                                
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
   Uterus                                             (60)         (60)         (59)         (60)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hydrometra                                      17 (28%)     12 (20%)     13 (22%)     16 (27%)                               
      Hyperplasia, Focal, Histiocytic                               1 (2%)                                                          
      Inflammation, Suppurative                        4 (7%)       2 (3%)                    3 (5%)                                
      Endometrium, Hyperplasia, Cystic                59 (98%)     60 (100%)    58 (98%)     57 (95%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)                                                                       
      Hyperplasia, Focal, Histiocytic                  1 (2%)                                                                       
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (7)          (8)          (12)         (9)                                    
      Hyperplasia, Cystic                              1 (14%)                                                                      
      Iliac, Hemorrhage                                1 (14%)                                                                      
      Iliac, Hyperplasia                               2 (29%)      1 (13%)                   1 (11%)                               
      Inguinal, Hyperplasia                                                      2 (17%)                                            
      Lumbar, Hyperplasia                                                                     1 (11%)                               
      Mediastinal, Hyperplasia                         1 (14%)      1 (13%)      2 (17%)      1 (11%)                               
      Mediastinal, Hyperplasia, Lymphoid               1 (14%)                                1 (11%)                               
      Mediastinal, Inflammation, Focal, Suppurative                                           1 (11%)                               
      Renal, Hemorrhage                                1 (14%)                                                                      
      Renal, Hyperplasia                               2 (29%)      2 (25%)      1 (8%)       3 (33%)                               
   Lymph Node, Mandibular                             (57)         (60)         (59)         (57)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)       2 (3%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (59)         (56)         (58)         (56)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (4%)                    1 (2%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            6 (10%)      3 (5%)       3 (5%)       1 (2%)                                
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Angiectasis                                                                             1 (2%)                                
      Congestion                                                    1 (2%)                                                          
      Fibrosis, Focal                                               1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                14 (23%)     14 (23%)     13 (22%)     13 (22%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            3 (5%)       8 (13%)      7 (12%)      7 (12%)                               
      Necrosis, Focal                                  1 (2%)                                                                       
   Thymus                                             (53)         (59)         (56)         (54)                                   
      Cyst                                                          1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (60)                                   
      Ectasia                                          3 (5%)       1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Skin                                               (60)         (60)         (60)         (60)                                   
      Alopecia, Focal                                                            1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Epidermis, Hyperplasia, Focal                                                           1 (2%)                                
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Inflammation, Suppurative                        1 (100%)     1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Atrophy, Focal                                   3 (5%)       4 (7%)       1 (2%)       1 (2%)                                
      Artery, Meninges, Inflammation, Chronic                                    1 (2%)                                             
      Meninges, Cyst                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                                          1 (2%)       2 (3%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    2 (3%)       2 (3%)                                
      Interstitium, Inflammation, Suppurative          2 (3%)                                 1 (2%)                                
      Mediastinum, Inflammation, Chronic                                                      1 (2%)                                
      Pleura, Mediastinum, Inflammation, Chronic                                 1 (2%)       1 (2%)                                
   Nose                                               (60)         (60)         (58)         (59)                                   
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
      Mucosa, Glands, Dilatation, Focal               16 (27%)     27 (45%)     16 (28%)     26 (44%)                               
      Nasolacrimal Duct, Cyst                                       1 (2%)                                                          
   Trachea                                            (60)         (60)         (59)         (60)                                   
      Artery, Peritracheal Tissue, Inflammation,                                                                                    
           Chronic                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (59)                                   
      Congestion                                                    2 (3%)                                                          
      Cyst                                                                                    1 (2%)                                
      Hydronephrosis                                   1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            2 (3%)                                 1 (2%)                                
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Nephropathy                                     30 (50%)     32 (53%)     35 (59%)     28 (47%)                               
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Renal Tubule, Casts                                                                     1 (2%)                                
      Renal Tubule, Dilatation, Focal                                            2 (3%)                                             
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
      Renal Tubule, Pigmentation, Hemoglobin                                                  1 (2%)                                
   Urinary Bladder                                    (60)         (59)         (59)         (59)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      2 (3%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10            9            9                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            1            6            2                                     
    Moribund Sacrifice                                 6            3            7            7                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           46           38           42                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (60)         (60)         (57)         (59)                                   
      Perforation                                                                1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid                          2 (3%)       1 (2%)       1 (2%)                                
   Intestine Small, Ileum                             (59)         (59)         (58)         (58)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      2 (3%)       1 (2%)                    1 (2%)                                
      Basophilic Focus                                 5 (8%)       2 (3%)       2 (3%)       5 (8%)                                
      Clear Cell Focus                                 4 (7%)       3 (5%)       7 (12%)      3 (5%)                                
      Clear Cell Focus, Multiple                       2 (3%)       4 (7%)       2 (3%)       1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Eosinophilic Focus                               7 (12%)      4 (7%)       4 (7%)       3 (5%)                                
      Eosinophilic Focus, Multiple                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Fatty Change                                     1 (2%)                                                                       
      Fatty Change, Focal                              7 (12%)      8 (13%)      6 (10%)      3 (5%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                                    1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Inflammation, Focal                              2 (3%)                    1 (2%)                                             
      Mixed Cell Focus                                 5 (8%)       8 (13%)      4 (7%)       5 (8%)                                
      Mixed Cell Focus, Multiple                                                              3 (5%)                                
      Necrosis, Focal                                  2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Pigmentation, Focal                              1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                                        1 (2%)                                                          
      Centrilobular, Necrosis                                                    1 (2%)                                             
      Oval Cell, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                          (2)          (7)          (15)         (1)                                    
      Inflammation, Chronic                                         1 (14%)      3 (20%)                                            
      Artery, Inflammation, Chronic                    1 (50%)                   1 (7%)                                             
      Fat, Necrosis                                                 5 (71%)      7 (47%)      1 (100%)                              

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Atrophy, Diffuse                                 1 (2%)       1 (2%)                                                          
      Atrophy, Focal                                                             2 (3%)                                             
      Duct, Cyst                                       1 (2%)       2 (3%)                                                          
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
      Edema                                                                      1 (2%)                                             
      Erosion                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            3 (5%)       2 (3%)       1 (2%)                                             
      Epithelium, Hyperplasia                          4 (7%)       2 (3%)       1 (2%)                                             
   Stomach, Glandular                                 (59)         (60)         (60)         (59)                                   
      Edema                                                                      1 (2%)                                             
      Erosion                                          1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Pigmentation, Focal                                                        1 (2%)                                             
      Epithelium, Hyperplasia, Cystic                               1 (2%)                                                          
   Tooth                                              (29)         (27)         (18)         (28)                                   
      Incisor, Dysplasia                              29 (100%)    27 (100%)    18 (100%)    28 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic, Focal                     2 (3%)                                                                       
      Artery, Degeneration                                                                    1 (2%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (59)         (60)                                   
      Accessory Adrenal Cortical Nodule                3 (5%)       1 (2%)                    2 (3%)                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)       3 (5%)       2 (3%)                                             
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Subcapsular, Hyperplasia                                      1 (2%)                    2 (3%)                                
      Subcapsular, Hyperplasia, Focal                  5 (8%)       4 (7%)       6 (10%)      8 (13%)                               
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                                                1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (59)         (56)         (58)         (53)                                   
      Cyst                                             2 (3%)       2 (4%)                                                          
   Pituitary Gland                                    (55)         (52)         (53)         (57)                                   
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             1 (2%)       2 (4%)       3 (6%)       3 (5%)                                
   Thyroid Gland                                      (60)         (60)         (59)         (60)                                   
      Degeneration, Cystic, Focal                      7 (12%)      5 (8%)       6 (10%)      6 (10%)                               
      Fibrosis, Focal                                  1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      Follicle, Hypertrophy, Focal                                  1 (2%)                                                          
      Follicular Cell, Hyperplasia                     6 (10%)     12 (20%)      6 (10%)      6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (3)                                    
      Pelvic, Inflammation, Chronic                                                           2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (4)          (6)          (2)          (1)                                    
      Inflammation, Chronic                                                                   1 (100%)                              
   Epididymis                                         (60)         (60)         (60)         (59)                                   
      Spermatocele                                                                            1 (2%)                                
   Preputial Gland                                    (60)         (59)         (59)         (59)                                   
      Degeneration, Cystic                            22 (37%)     30 (51%)     33 (56%)     29 (49%)                               
      Inflammation, Chronic                            8 (13%)      5 (8%)       8 (14%)      5 (8%)                                
   Prostate                                           (59)         (60)         (60)         (60)                                   
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)                    2 (3%)       1 (2%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
      Fibrosis                                                                                1 (2%)                                
      Granuloma Sperm                                  1 (2%)                                                                       
      Mineralization, Focal                                         1 (2%)                    1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Germinal Epithelium, Degeneration                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (3)          (3)          (6)          (3)                                    
      Bronchial, Hyperplasia                                                     1 (17%)                                            
      Iliac, Hemorrhage                                                          1 (17%)                                            
      Inguinal, Hyperplasia                            2 (67%)      1 (33%)                                                         
      Inguinal, Hyperplasia, Lymphoid                               1 (33%)      1 (17%)                                            
      Inguinal, Pigmentation                                        1 (33%)                                                         
      Mediastinal, Hyperplasia                                      1 (33%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hyperplasia, Lymphoid               1 (33%)                                                                      
      Renal, Hemorrhage                                                          1 (17%)                                            
   Lymph Node, Mandibular                             (58)         (58)         (58)         (60)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (58)         (60)         (60)                                   
      Ectasia                                          2 (3%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)       2 (3%)                                             
      Hemorrhage                                      12 (20%)     11 (19%)      9 (15%)      9 (15%)                               
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Histiocytic                                      1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            2 (3%)       3 (5%)       2 (3%)       1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Accessory Spleen                                 1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 8 (13%)     12 (20%)     17 (28%)     11 (18%)                               
      Hyperplasia, Lymphoid                                         2 (3%)       1 (2%)       1 (2%)                                
   Thymus                                             (53)         (48)         (52)         (51)                                   
      Cyst                                             4 (8%)       8 (17%)      5 (10%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Alopecia                                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                     2 (3%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                                 2 (3%)       1 (2%)                                
      Subcutaneous Tissue, Mineralization, Focal                    1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Necrosis, Focal                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                       (1)          (1)                                    
      Mineralization, Focal                            1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Atrophy, Focal                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05217-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:45  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (58)         (60)         (60)                                   
      Congestion                                                    1 (2%)       1 (2%)                                             
      Hemorrhage                                                    2 (3%)                                                          
      Hyperplasia, Histiocytic                         2 (3%)       4 (7%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       1 (2%)                                
      Thrombosis, Multiple                                                       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 4 (7%)       5 (9%)       4 (7%)       9 (15%)                               
      Interstitium, Edema                                                                     1 (2%)                                
      Mediastinum, Edema                                                         1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Suppurative                        2 (3%)       2 (3%)                                                          
      Mucosa, Cyst                                                                            1 (2%)                                
      Mucosa, Polyp, Inflammatory                                   1 (2%)                                                          
      Mucosa, Glands, Dilatation, Focal                9 (15%)     18 (30%)     10 (17%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (9)          (6)          (3)                                    
      Hyperplasia, Focal                                            1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hydronephrosis                                                1 (2%)                    1 (2%)                                
      Hyperplasia, Focal                                                                      1 (2%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Nephropathy                                     50 (83%)     47 (78%)     48 (80%)     50 (83%)                               
      Pelvis, Inflammation, Suppurative                                                       1 (2%)                                
      Renal Tubule, Dilatation, Diffuse                1 (2%)                                                                       
      Renal Tubule, Dilatation, Focal                               1 (2%)                    1 (2%)                                
      Renal Tubule, Hyperplasia, Focal                 1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Calculus Micro Observation Only                               1 (2%)                                                          
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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