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TDMS Study 05217-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                               T-BUTYLHYDROQUINONE                                  DATE: 04/04/96       
EXPERIMENT: 05217 TEST: 05                                                                                     TIME: 09:19:12       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-85219                              ROUTE: DOSED FEED                                              NTP C#: C62157       
PATHOLOGIST: D.R. FARNELL                                                                                      CAS: 1948-33-0       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                               T-BUTYLHYDROQUINONE                                  DATE: 04/04/96       
EXPERIMENT: 05217 TEST: 05                                                                                     TIME: 09:19:12       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-85219                              ROUTE: DOSED FEED                                              NTP C#: C62157       
PATHOLOGIST: D.R. FARNELL                                                                                      CAS: 1948-33-0       




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                               T-BUTYLHYDROQUINONE                                  DATE: 04/04/96       
EXPERIMENT: 05217 TEST: 05                                                                                     TIME: 09:19:12       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-85219                              ROUTE: DOSED FEED                                              NTP C#: C62157       
PATHOLOGIST: D.R. FARNELL                                                                                      CAS: 1948-33-0       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF T-BUTYLHYDROQUINONE

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Spleen                        Hemangiosarcoma
              All Organs                    Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Benign Tumors

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              All Organs                    Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
                                             Cell Type
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    4/60 (7%)    1/59 (2%)    2/60 (3%)  |  0/60 (0%)    0/59 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.6%         8.7%         2.7%         4.8%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    4/46 (9%)    1/37 (3%)    2/42 (5%)  |  0/38 (0%)    0/35 (0%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      727 (T)      727 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.592N     P=0.233      P=0.750      P=0.526    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.592N     P=0.233      P=0.750      P=0.526    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.592N     P=0.233      P=0.750      P=0.526    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.595                                           |    (e)                                             |
|FISHER EXACT           |               P=0.182      P=0.748      P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    8/60 (13%)   4/60 (7%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    6/60 (10%)   1/60 (2%)  |
|ADJUSTED (b)           |   7.7%        17.4%        10.5%         7.0%      |   0.0%         0.0%        15.0%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  3/39 (8%)    8/46 (17%)   4/38 (11%)   2/42 (5%)  |  0/38 (0%)    0/35 (0%)    6/40 (15%)   1/43 (2%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      727 (T)      688       |   ---          ---          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.331N     P=0.159      P=0.486      P=0.631N   |  P=0.294        (e)        P=0.020 *    P=0.525    |
|INCIDENTAL TUMOR       |  P=0.357N     P=0.159      P=0.486      P=0.600    |  P=0.294        (e)        P=0.020 *    P=0.525    |
|LOGISTIC REGRESSION    |  P=0.351N     P=0.159      P=0.486      P=0.660N   |  P=0.294        (e)        P=0.020 *    P=0.525    |
|COCHRAN-ARMITAGE       |  P=0.339N                                          |  P=0.238                                           |
|FISHER EXACT           |               P=0.102      P=0.500      P=0.660N   |                 (e)        P=0.014 *    P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.3%         0.0%      |   0.0%         2.9%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    0/46 (0%)    2/38 (5%)    0/42 (0%)  |  0/38 (0%)    1/35 (3%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          727 (T)      ---       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.598        (e)        P=0.233        (e)      |  P=0.542N     P=0.484        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.598        (e)        P=0.233        (e)      |  P=0.542N     P=0.484        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.598        (e)        P=0.233        (e)      |  P=0.542N     P=0.484        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.595                                           |  P=0.567N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    8/60 (13%)   6/60 (10%)   3/60 (5%)  |  0/60 (0%)    1/60 (2%)    6/60 (10%)   1/60 (2%)  |
|ADJUSTED (b)           |   7.7%        17.4%        15.8%         7.0%      |   0.0%         2.9%        15.0%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  3/39 (8%)    8/46 (17%)   6/38 (16%)   2/42 (5%)  |  0/38 (0%)    1/35 (3%)    6/40 (15%)   1/43 (2%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      727 (T)      688       |   ---          734 (T)      734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.367N     P=0.159      P=0.228      P=0.631N   |  P=0.379      P=0.484      P=0.020 *    P=0.525    |
|INCIDENTAL TUMOR       |  P=0.392N     P=0.159      P=0.228      P=0.600    |  P=0.379      P=0.484      P=0.020 *    P=0.525    |
|LOGISTIC REGRESSION    |  P=0.389N     P=0.159      P=0.228      P=0.660N   |  P=0.379      P=0.484      P=0.020 *    P=0.525    |
|COCHRAN-ARMITAGE       |  P=0.376N                                          |  P=0.313                                           |
|FISHER EXACT           |               P=0.102      P=0.245      P=0.660N   |               P=0.500      P=0.014 *    P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    3/60 (5%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         2.2%         7.3%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    1/46 (2%)    2/38 (5%)    0/42 (0%)  |  0/38 (0%)    0/35 (0%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          727 (T)      654          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.632N     P=0.533      P=0.123        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.580      P=0.533      P=0.120        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.629      P=0.533      P=0.118        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.633                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.122        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    3/60 (5%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.6%         2.2%         7.3%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    1/46 (2%)    2/38 (5%)    0/42 (0%)  |  0/38 (0%)    0/35 (0%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      654          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.407N     P=0.724N     P=0.304      P=0.485N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.459N     P=0.724N     P=0.300      P=0.485N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.415N     P=0.724N     P=0.298      P=0.485N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.409N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.752N     P=0.309      P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/60 (0%)    2/60 (3%)  |  1/60 (2%)    0/60 (0%)    1/57 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.6%         2.1%         0.0%         4.8%      |   2.4%         0.0%         2.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    0/46 (0%)    0/38 (0%)    2/42 (5%)  |  0/38 (0%)    0/35 (0%)    1/40 (3%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      710          ---          727 (T)   |   667          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.368      P=0.727N     P=0.505N     P=0.526    |  P=0.376N     P=0.505N     P=0.749N     P=0.473N   |
|INCIDENTAL TUMOR       |  P=0.308      P=0.647      P=0.505N     P=0.526    |  P=0.385N     P=0.388N     P=0.730N     P=0.455N   |
|LOGISTIC REGRESSION    |  P=0.359      P=0.749N     P=0.505N     P=0.526    |  P=0.396N     P=0.501N     P=0.760      P=0.500N   |
|COCHRAN-ARMITAGE       |  P=0.367                                           |  P=0.407N                                          |
|FISHER EXACT           |               P=0.752N     P=0.500N     P=0.500    |               P=0.500N     P=0.739      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   7.1%         2.2%         2.6%         4.3%      |   2.0%         0.0%         0.0%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  2/39 (5%)    1/46 (2%)    1/38 (3%)    1/42 (2%)  |  0/38 (0%)    0/35 (0%)    0/40 (0%)    1/43 (2%)  |
|FIRST INCIDENCE (DAYS) |   595          727 (T)      727 (T)      589       |   461          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.471N     P=0.262N     P=0.317N     P=0.478N   |  P=0.610      P=0.500N     P=0.504N     P=0.747N   |
|INCIDENTAL TUMOR       |  P=0.330N     P=0.264N     P=0.278N     P=0.294N   |  P=0.654      P=0.227N     P=0.500N     P=0.630N   |
|LOGISTIC REGRESSION    |  P=0.479N     P=0.298N     P=0.310N     P=0.501N   |  P=0.601      P=0.478N     P=0.467N     P=0.758N   |
|COCHRAN-ARMITAGE       |  P=0.474N                                          |  P=0.595                                           |
|FISHER EXACT           |               P=0.309N     P=0.309N     P=0.500N   |               P=0.500N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/60 (48%)  23/60 (38%)  23/60 (38%)  14/60 (23%) |  9/60 (15%)  20/60 (33%)  17/60 (28%)   5/60 (8%)  |
|ADJUSTED (b)           |  61.2%        48.7%        53.8%        31.7%      |  22.7%        51.0%        38.1%        11.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   1/9 (11%)    0/9 (0%)   |  0/9 (0%)     0/8 (0%)     1/9 (11%)    0/6 (0%)   |
|TERMINAL (d)           | 21/39 (54%)  22/46 (48%)  19/38 (50%)  12/42 (29%) |  8/38 (21%)  16/35 (46%)  13/40 (33%)   5/43 (12%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      409          630       |   582          598          457 (I)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003N**   P=0.055N     P=0.221N     P=0.003N** |  P=0.026N*    P=0.008 **   P=0.079      P=0.135N   |
|INCIDENTAL TUMOR       |  P=0.004N**   P=0.140N     P=0.167N     P=0.004N** |  P=0.044N*    P=0.010 **   P=0.061      P=0.183N   |
|LOGISTIC REGRESSION    |  P=0.003N**   P=0.128N     P=0.189N     P=0.003N** |  P=0.031N*    P=0.011 *    P=0.068      P=0.140N   |
|COCHRAN-ARMITAGE       |  P=0.004N**                                        |  P=0.064N                                          |
|FISHER EXACT           |               P=0.179N     P=0.179N     P=0.004N** |               P=0.016 *    P=0.060      P=0.197N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)  11/60 (18%)  12/60 (20%)   9/60 (15%) |  8/60 (13%)   9/60 (15%)   8/60 (13%)   5/60 (8%)  |
|ADJUSTED (b)           |  19.1%        22.8%        25.8%        19.0%      |  18.4%        20.6%        17.6%        11.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     1/9 (11%)  |  0/9 (0%)     1/8 (13%)    0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  6/39 (15%)   9/46 (20%)   6/38 (16%)   5/42 (12%) |  4/38 (11%)   4/35 (11%)   4/40 (10%)   5/43 (12%) |
|FIRST INCIDENCE (DAYS) |   619          619          409          456 (I)   |   461          457 (I)      548          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.495      P=0.437      P=0.224      P=0.532    |  P=0.142N     P=0.459      P=0.561N     P=0.216N   |
|INCIDENTAL TUMOR       |  P=0.476N     P=0.358      P=0.314      P=0.571    |  P=0.272N     P=0.574      P=0.589      P=0.304N   |
|LOGISTIC REGRESSION    |  P=0.529      P=0.342      P=0.228      P=0.496    |  P=0.336N     P=0.502      P=0.485      P=0.259N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.196N                                          |
|FISHER EXACT           |               P=0.309      P=0.232      P=0.500    |               P=0.500      P=0.605N     P=0.279N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)  11/60 (18%)  12/60 (20%)   9/60 (15%) |  8/60 (13%)   9/60 (15%)   9/60 (15%)   5/60 (8%)  |
|ADJUSTED (b)           |  19.1%        22.8%        25.8%        19.0%      |  18.4%        20.6%        19.9%        11.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     1/9 (11%)  |  0/9 (0%)     1/8 (13%)    0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  6/39 (15%)   9/46 (20%)   6/38 (16%)   5/42 (12%) |  4/38 (11%)   4/35 (11%)   5/40 (13%)   5/43 (12%) |
|FIRST INCIDENCE (DAYS) |   619          619          409          456 (I)   |   461          457 (I)      548          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.495      P=0.437      P=0.224      P=0.532    |  P=0.150N     P=0.459      P=0.543      P=0.216N   |
|INCIDENTAL TUMOR       |  P=0.476N     P=0.358      P=0.314      P=0.571    |  P=0.283N     P=0.574      P=0.482      P=0.304N   |
|LOGISTIC REGRESSION    |  P=0.529      P=0.342      P=0.228      P=0.496    |  P=0.345N     P=0.502      P=0.383      P=0.259N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.208N                                          |
|FISHER EXACT           |               P=0.309      P=0.232      P=0.500    |               P=0.500      P=0.500      P=0.279N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/60 (53%)  29/60 (48%)  30/60 (50%)  18/60 (30%) | 17/60 (28%)  29/60 (48%)  24/60 (40%)  10/60 (17%) |
|ADJUSTED (b)           |  66.4%        59.0%        64.3%        38.7%      |  38.9%        65.3%        49.6%        23.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   1/9 (11%)    1/9 (11%)  |  0/9 (0%)     1/8 (13%)    1/9 (11%)    0/6 (0%)   |
|TERMINAL (d)           | 23/39 (59%)  26/46 (57%)  22/38 (58%)  14/42 (33%) | 12/38 (32%)  20/35 (57%)  16/40 (40%)  10/43 (23%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      409          456 (I)   |   461          457 (I)      457 (I)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.008N**   P=0.133N     P=0.489N     P=0.007N** |  P=0.007N**   P=0.014 *    P=0.185      P=0.050N   |
|INCIDENTAL TUMOR       |  P=0.003N**   P=0.311N     P=0.366N     P=0.008N** |  P=0.021N*    P=0.017 *    P=0.112      P=0.094N   |
|LOGISTIC REGRESSION    |  P=0.005N**   P=0.391N     P=0.454N     P=0.007N** |  P=0.021N*    P=0.014 *    P=0.090      P=0.065N   |
|COCHRAN-ARMITAGE       |  P=0.006N**                                        |  P=0.021N*                                         |
|FISHER EXACT           |               P=0.358N     P=0.428N     P=0.008N** |               P=0.019 *    P=0.124      P=0.095N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/60 (53%)  29/60 (48%)  30/60 (50%)  18/60 (30%) | 17/60 (28%)  29/60 (48%)  24/60 (40%)  10/60 (17%) |
|ADJUSTED (b)           |  66.4%        59.0%        64.3%        38.7%      |  38.9%        65.3%        49.6%        23.3%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   1/9 (11%)    1/9 (11%)  |  0/9 (0%)     1/8 (13%)    1/9 (11%)    0/6 (0%)   |
|TERMINAL (d)           | 23/39 (59%)  26/46 (57%)  22/38 (58%)  14/42 (33%) | 12/38 (32%)  20/35 (57%)  16/40 (40%)  10/43 (23%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      409          456 (I)   |   461          457 (I)      457 (I)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.008N**   P=0.133N     P=0.489N     P=0.007N** |  P=0.007N**   P=0.014 *    P=0.185      P=0.050N   |
|INCIDENTAL TUMOR       |  P=0.003N**   P=0.311N     P=0.366N     P=0.008N** |  P=0.021N*    P=0.017 *    P=0.112      P=0.094N   |
|LOGISTIC REGRESSION    |  P=0.005N**   P=0.391N     P=0.454N     P=0.007N** |  P=0.021N*    P=0.014 *    P=0.090      P=0.065N   |
|COCHRAN-ARMITAGE       |  P=0.006N**                                        |  P=0.021N*                                         |
|FISHER EXACT           |               P=0.358N     P=0.428N     P=0.008N** |               P=0.019 *    P=0.124      P=0.095N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/60 (20%)  11/58 (19%)  11/60 (18%)  10/60 (17%) |  4/60 (7%)    2/60 (3%)    4/60 (7%)    3/60 (5%)  |
|ADJUSTED (b)           |  28.1%        23.3%        24.7%        21.4%      |   9.5%         5.3%        10.0%         7.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   2/9 (22%)    1/9 (11%)  |  1/9 (11%)    0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  9/39 (23%)   9/44 (20%)   7/38 (18%)   7/42 (17%) |  3/38 (8%)    1/35 (3%)    4/40 (10%)   3/43 (7%)  |
|FIRST INCIDENCE (DAYS) |   647          456 (I)      456 (I)      456 (I)   |   457 (I)      706          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.365N     P=0.393N     P=0.536N     P=0.364N   |  P=0.451N     P=0.374N     P=0.618N     P=0.473N   |
|INCIDENTAL TUMOR       |  P=0.312N     P=0.568N     P=0.510N     P=0.428N   |  P=0.456N     P=0.331N     P=0.618N     P=0.473N   |
|LOGISTIC REGRESSION    |  P=0.365N     P=0.508N     P=0.511N     P=0.410N   |  P=0.476N     P=0.341N     P=0.631N     P=0.484N   |
|COCHRAN-ARMITAGE       |  P=0.356N                                          |  P=0.519N                                          |
|FISHER EXACT           |               P=0.536N     P=0.500N     P=0.407N   |               P=0.340N     P=0.641N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    5/58 (9%)    3/60 (5%)    6/60 (10%) |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   7.0%        11.0%         7.2%        13.3%      |   5.3%         0.0%         2.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    4/44 (9%)    1/38 (3%)    4/42 (10%) |  2/38 (5%)    0/35 (0%)    1/40 (3%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          654          666          595       |   734 (T)      ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.242      P=0.418      P=0.648      P=0.266    |  P=0.166N     P=0.257N     P=0.482N     P=0.212N   |
|INCIDENTAL TUMOR       |  P=0.191      P=0.158      P=0.666      P=0.226    |  P=0.166N     P=0.257N     P=0.482N     P=0.212N   |
|LOGISTIC REGRESSION    |  P=0.234      P=0.355      P=0.657      P=0.242    |  P=0.166N     P=0.257N     P=0.482N     P=0.212N   |
|COCHRAN-ARMITAGE       |  P=0.241                                           |  P=0.188N                                          |
|FISHER EXACT           |               P=0.340      P=0.660N     P=0.245    |               P=0.248N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  16/58 (28%)  13/60 (22%)  15/60 (25%) |  6/60 (10%)   2/60 (3%)    5/60 (8%)    3/60 (5%)  |
|ADJUSTED (b)           |  33.7%        33.5%        28.8%        31.2%      |  14.6%         5.3%        12.5%         7.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   2/9 (22%)    1/9 (11%)  |  1/9 (11%)    0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           | 10/39 (26%)  13/44 (30%)   8/38 (21%)  10/42 (24%) |  5/38 (13%)   1/35 (3%)    5/40 (13%)   3/43 (7%)  |
|FIRST INCIDENCE (DAYS) |   647          456 (I)      456 (I)      456 (I)   |   457 (I)      706          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.484N     P=0.531N     P=0.456N     P=0.529N   |  P=0.235N     P=0.164N     P=0.467N     P=0.212N   |
|INCIDENTAL TUMOR       |  P=0.444N     P=0.312      P=0.426N     P=0.562    |  P=0.238N     P=0.139N     P=0.467N     P=0.212N   |
|LOGISTIC REGRESSION    |  P=0.454N     P=0.364      P=0.427N     P=0.582    |  P=0.252N     P=0.139N     P=0.477N     P=0.221N   |
|COCHRAN-ARMITAGE       |  P=0.475N                                          |  P=0.300N                                          |
|FISHER EXACT           |               P=0.456      P=0.415N     P=0.583N   |               P=0.136N     P=0.500N     P=0.245N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/59 (3%)    2/57 (4%)    4/56 (7%)    2/56 (4%)  |
|ADJUSTED (b)           |                                                    |   5.4%         5.3%         9.5%         5.1%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/9 (0%)     0/8 (0%)     1/9 (11%)    0/6 (0%)   |
|TERMINAL (d)           |                                                    |  2/37 (5%)    1/34 (3%)    3/38 (8%)    2/39 (5%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   734 (T)      654          457 (I)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.566      P=0.671      P=0.348      P=0.676N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.567      P=0.691      P=0.348      P=0.676N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.542      P=0.676      P=0.319      P=0.676N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.521                                           |
|FISHER EXACT           |                                                    |               P=0.678      P=0.315      P=0.671    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/55 (2%)    0/52 (0%)    0/53 (0%)    0/57 (0%)  |  5/58 (9%)    5/52 (10%)   5/55 (9%)    4/55 (7%)  |
|ADJUSTED (b)           |   2.5%         0.0%         0.0%         0.0%      |  12.3%        16.1%        13.2%        10.5%      |
|INTERIM SACRIFICE 1 (c)|  0/9 (0%)     0/10 (0%)    0/8 (0%)     0/8 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/36 (0%)    0/39 (0%)    0/33 (0%)    0/40 (0%)  |  3/36 (8%)    5/31 (16%)   5/38 (13%)   4/38 (11%) |
|FIRST INCIDENCE (DAYS) |   723          ---          ---          ---       |   567          734 (T)      734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.306N     P=0.472N     P=0.505N     P=0.490N   |  P=0.351N     P=0.550      P=0.600N     P=0.465N   |
|INCIDENTAL TUMOR       |  P=0.382N     P=0.872N     P=0.473N     P=0.748N   |  P=0.467N     P=0.481      P=0.514      P=0.602    |
|LOGISTIC REGRESSION    |  P=0.302N     P=0.501N     P=0.514N     P=0.489N   |  P=0.369N     P=0.549      P=0.627      P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.302N                                          |  P=0.437N                                          |
|FISHER EXACT           |               P=0.514N     P=0.509N     P=0.491N   |               P=0.558      P=0.595      P=0.534N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/55 (2%)    0/52 (0%)    0/53 (0%)    0/57 (0%)  |  5/58 (9%)    6/52 (12%)   5/55 (9%)    4/55 (7%)  |
|ADJUSTED (b)           |   2.5%         0.0%         0.0%         0.0%      |  12.3%        18.0%        13.2%        10.5%      |
|INTERIM SACRIFICE 1 (c)|  0/9 (0%)     0/10 (0%)    0/8 (0%)     0/8 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/36 (0%)    0/39 (0%)    0/33 (0%)    0/40 (0%)  |  3/36 (8%)    5/31 (16%)   5/38 (13%)   4/38 (11%) |
|FIRST INCIDENCE (DAYS) |   723          ---          ---          ---       |   567          598          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.306N     P=0.472N     P=0.505N     P=0.490N   |  P=0.310N     P=0.423      P=0.600N     P=0.465N   |
|INCIDENTAL TUMOR       |  P=0.382N     P=0.872N     P=0.473N     P=0.748N   |  P=0.476N     P=0.322      P=0.514      P=0.602    |
|LOGISTIC REGRESSION    |  P=0.302N     P=0.501N     P=0.514N     P=0.489N   |  P=0.338N     P=0.413      P=0.627      P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.302N                                          |  P=0.393N                                          |
|FISHER EXACT           |               P=0.514N     P=0.509N     P=0.491N   |               P=0.423      P=0.595      P=0.534N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.3%         5.1%         5.0%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    0/46 (0%)    0/38 (0%)    0/42 (0%)  |  2/38 (5%)    1/35 (3%)    2/40 (5%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   734 (T)      623          734 (T)      703       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.315N     P=0.675      P=0.676N     P=0.450N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.405N     P=0.641      P=0.676N     P=0.446N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.340N     P=0.690      P=0.676N     P=0.463N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.373N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.691N     P=0.691N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.3%         5.1%         5.0%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    0/46 (0%)    0/38 (0%)    0/42 (0%)  |  2/38 (5%)    1/35 (3%)    2/40 (5%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   734 (T)      623          734 (T)      703       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.315N     P=0.675      P=0.676N     P=0.450N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.405N     P=0.641      P=0.676N     P=0.446N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.340N     P=0.690      P=0.676N     P=0.463N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.373N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.691N     P=0.691N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.6%         2.2%         2.6%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    1/46 (2%)    1/38 (3%)    0/42 (0%)  |  0/38 (0%)    0/35 (0%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   619          727 (T)      727 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.154N     P=0.457N     P=0.508N     P=0.236N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.105N     P=0.462N     P=0.460N     P=0.123N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.155N     P=0.494N     P=0.504N     P=0.238N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.153N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    2/60 (3%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.3%         5.1%         2.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    0/46 (0%)    0/38 (0%)    0/42 (0%)  |  2/38 (5%)    1/35 (3%)    1/40 (3%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   734 (T)      623          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.105N     P=0.675      P=0.482N     P=0.212N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.150N     P=0.641      P=0.482N     P=0.212N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.113N     P=0.690      P=0.482N     P=0.212N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.126N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.691N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    1/59 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   9.7%         2.2%         0.0%         0.0%      |   0.0%         0.0%         2.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  3/39 (8%)    1/46 (2%)    0/38 (0%)    0/42 (0%)  |  0/38 (0%)    0/35 (0%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   647          727 (T)      ---          ---       |   ---          ---          723          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.020N*    P=0.144N     P=0.068N     P=0.060N   |  P=0.713        (e)        P=0.515        (e)      |
|INCIDENTAL TUMOR       |  P=0.024N*    P=0.207N     P=0.067N     P=0.092N   |  P=0.705        (e)        P=0.545        (e)      |
|LOGISTIC REGRESSION    |  P=0.020N*    P=0.166N     P=0.066N     P=0.063N   |  P=0.708        (e)        P=0.509        (e)      |
|COCHRAN-ARMITAGE       |  P=0.020N*                                         |  P=0.694                                           |
|FISHER EXACT           |               P=0.182N     P=0.059N     P=0.059N   |                 (e)        P=0.496        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         2.2%         2.6%         4.7%      |   2.6%         2.0%         0.0%         4.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    1/46 (2%)    1/38 (3%)    1/42 (2%)  |  1/38 (3%)    0/35 (0%)    0/40 (0%)    2/43 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          727 (T)      727 (T)      688       |   734 (T)      494          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.155      P=0.533      P=0.495      P=0.251    |  P=0.405      P=0.751      P=0.490N     P=0.543    |
|INCIDENTAL TUMOR       |  P=0.114      P=0.533      P=0.495      P=0.111    |  P=0.436      P=0.635N     P=0.490N     P=0.543    |
|LOGISTIC REGRESSION    |  P=0.148      P=0.533      P=0.495      P=0.238    |  P=0.369      P=0.759N     P=0.490N     P=0.543    |
|COCHRAN-ARMITAGE       |  P=0.153                                           |  P=0.367                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.248    |               P=0.752N     P=0.500N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         2.2%         2.6%         4.7%      |   2.6%         0.0%         0.0%         4.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    1/46 (2%)    1/38 (3%)    1/42 (2%)  |  1/38 (3%)    0/35 (0%)    0/40 (0%)    2/43 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          727 (T)      727 (T)      688       |   734 (T)      ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.155      P=0.533      P=0.495      P=0.251    |  P=0.284      P=0.516N     P=0.490N     P=0.543    |
|INCIDENTAL TUMOR       |  P=0.114      P=0.533      P=0.495      P=0.111    |  P=0.284      P=0.516N     P=0.490N     P=0.543    |
|LOGISTIC REGRESSION    |  P=0.148      P=0.533      P=0.495      P=0.238    |  P=0.284      P=0.516N     P=0.490N     P=0.543    |
|COCHRAN-ARMITAGE       |  P=0.153                                           |  P=0.246                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.248    |               P=0.500N     P=0.500N     P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    2/59 (3%)    0/60 (0%)  |  1/60 (2%)    3/59 (5%)    2/59 (3%)    5/60 (8%)  |
|ADJUSTED (b)           |   2.6%         2.2%         4.3%         0.0%      |   2.6%         8.0%         5.1%        11.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/9 (11%)    0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    1/46 (2%)    1/38 (3%)    0/42 (0%)  |  1/38 (3%)    2/34 (6%)    2/39 (5%)    4/43 (9%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      456 (I)      ---       |   734 (T)      612          734 (T)      728       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372N     P=0.724N     P=0.482      P=0.485N   |  P=0.120      P=0.276      P=0.509      P=0.137    |
|INCIDENTAL TUMOR       |  P=0.372N     P=0.724N     P=0.482      P=0.485N   |  P=0.080      P=0.249      P=0.509      P=0.140    |
|LOGISTIC REGRESSION    |  P=0.365N     P=0.724N     P=0.499      P=0.485N   |  P=0.108      P=0.293      P=0.509      P=0.142    |
|COCHRAN-ARMITAGE       |  P=0.367N                                          |  P=0.081                                           |
|FISHER EXACT           |               P=0.752N     P=0.494      P=0.500N   |               P=0.303      P=0.494      P=0.103    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    2/59 (3%)    1/60 (2%)  |  1/60 (2%)    3/59 (5%)    2/59 (3%)    5/60 (8%)  |
|ADJUSTED (b)           |   2.6%         2.2%         4.3%         2.4%      |   2.6%         8.0%         5.1%        11.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/9 (11%)    0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  1/39 (3%)    1/46 (2%)    1/38 (3%)    1/42 (2%)  |  1/38 (3%)    2/34 (6%)    2/39 (5%)    4/43 (9%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      456 (I)      727 (T)   |   734 (T)      612          734 (T)      728       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.586      P=0.724N     P=0.482      P=0.745N   |  P=0.120      P=0.276      P=0.509      P=0.137    |
|INCIDENTAL TUMOR       |  P=0.586      P=0.724N     P=0.482      P=0.745N   |  P=0.080      P=0.249      P=0.509      P=0.140    |
|LOGISTIC REGRESSION    |  P=0.589      P=0.724N     P=0.499      P=0.745N   |  P=0.108      P=0.293      P=0.509      P=0.142    |
|COCHRAN-ARMITAGE       |  P=0.590                                           |  P=0.081                                           |
|FISHER EXACT           |               P=0.752N     P=0.494      P=0.752N   |               P=0.303      P=0.494      P=0.103    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/60 (0%)    0/60 (0%)    3/60 (5%)    1/60 (2%)  |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%         7.5%         2.3%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |                                                    |  0/38 (0%)    0/35 (0%)    3/40 (8%)    1/43 (2%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.291        (e)        P=0.130      P=0.525    |
|INCIDENTAL TUMOR       |                                                    |  P=0.291        (e)        P=0.130      P=0.525    |
|LOGISTIC REGRESSION    |                                                    |  P=0.291        (e)        P=0.130      P=0.525    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.248                                           |
|FISHER EXACT           |                                                    |                 (e)        P=0.122      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.1%         0.0%         2.6%         0.0%      |   0.0%         2.9%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  2/39 (5%)    0/46 (0%)    1/38 (3%)    0/42 (0%)  |  0/38 (0%)    1/35 (3%)    0/40 (0%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          727 (T)      ---       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.186N     P=0.203N     P=0.509N     P=0.222N   |  P=0.542N     P=0.484        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.186N     P=0.203N     P=0.509N     P=0.222N   |  P=0.542N     P=0.484        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.186N     P=0.203N     P=0.509N     P=0.222N   |  P=0.542N     P=0.484        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.188N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.248N     P=0.500N     P=0.248N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)   3/60 (5%)    2/60 (3%)    2/60 (3%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  15.8%         6.5%         5.3%         4.3%      |   4.6%         0.0%         2.4%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  4/39 (10%)   3/46 (7%)    2/38 (5%)    1/42 (2%)  |  1/38 (3%)    0/35 (0%)    0/40 (0%)    1/43 (2%)  |
|FIRST INCIDENCE (DAYS) |   595          727 (T)      727 (T)      589       |   461          ---          723          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.058N     P=0.120N     P=0.093N     P=0.081N   |  P=0.463N     P=0.249N     P=0.488N     P=0.471N   |
|INCIDENTAL TUMOR       |  P=0.027N*    P=0.153N     P=0.064N     P=0.027N*  |  P=0.439N     P=0.112N     P=0.448N     P=0.353N   |
|LOGISTIC REGRESSION    |  P=0.048N*    P=0.151N     P=0.085N     P=0.067N   |  P=0.500N     P=0.232N     P=0.503N     P=0.502N   |
|COCHRAN-ARMITAGE       |  P=0.057N                                          |  P=0.500N                                          |
|FISHER EXACT           |               P=0.161N     P=0.081N     P=0.081N   |               P=0.248N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/60 (15%)   3/60 (5%)    3/60 (5%)    2/60 (3%)  |  2/60 (3%)    1/60 (2%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  20.6%         6.5%         7.9%         4.3%      |   4.6%         2.9%         2.4%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  6/39 (15%)   3/46 (7%)    3/38 (8%)    1/42 (2%)  |  1/38 (3%)    1/35 (3%)    0/40 (0%)    1/43 (2%)  |
|FIRST INCIDENCE (DAYS) |   595          727 (T)      727 (T)      589       |   461          734 (T)      723          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.023N*    P=0.041N*    P=0.073N     P=0.027N*  |  P=0.370N     P=0.519N     P=0.488N     P=0.471N   |
|INCIDENTAL TUMOR       |  P=0.010N*    P=0.053N     P=0.051N     P=0.008N** |  P=0.348N     P=0.374N     P=0.448N     P=0.353N   |
|LOGISTIC REGRESSION    |  P=0.020N*    P=0.057N     P=0.067N     P=0.023N*  |  P=0.405N     P=0.498N     P=0.503N     P=0.502N   |
|COCHRAN-ARMITAGE       |  P=0.023N*                                         |  P=0.409N                                          |
|FISHER EXACT           |               P=0.063N     P=0.063N     P=0.027N*  |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |  2/60 (3%)    2/60 (3%)    3/60 (5%)    4/60 (7%)  |
|ADJUSTED (b)           |   0.0%         2.2%         4.7%         2.4%      |   5.0%         4.9%         6.8%         8.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  0/39 (0%)    1/46 (2%)    0/38 (0%)    1/42 (2%)  |  1/38 (3%)    1/35 (3%)    1/40 (3%)    2/43 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          727 (T)      657          727 (T)   |   673          562          618          418       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.366      P=0.533      P=0.240      P=0.515    |  P=0.277      P=0.673      P=0.526      P=0.393    |
|INCIDENTAL TUMOR       |  P=0.244      P=0.533      P=0.232      P=0.515    |  P=0.155      P=0.690N     P=0.510      P=0.484    |
|LOGISTIC REGRESSION    |  P=0.361      P=0.533      P=0.236      P=0.515    |  P=0.219      P=0.693      P=0.509      P=0.338    |
|COCHRAN-ARMITAGE       |  P=0.367                                           |  P=0.217                                           |
|FISHER EXACT           |               P=0.500      P=0.248      P=0.500    |               P=0.691N     P=0.500      P=0.340    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    2/60 (3%)    6/60 (10%)   4/60 (7%)  |  3/60 (5%)    9/60 (15%)  10/60 (17%)   8/60 (13%) |
|ADJUSTED (b)           |  10.3%         4.3%        14.9%         8.7%      |   7.1%        22.7%        24.3%        18.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     1/9 (11%)  |  0/9 (0%)     0/8 (0%)     0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           |  4/39 (10%)   2/46 (4%)    4/38 (11%)   3/42 (7%)  |  1/38 (3%)    5/35 (14%)   9/40 (23%)   7/43 (16%) |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      673          456 (I)   |   582          668          718          728       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.433      P=0.264N     P=0.356      P=0.614N   |  P=0.271      P=0.061      P=0.050 *    P=0.150    |
|INCIDENTAL TUMOR       |  P=0.370      P=0.264N     P=0.357      P=0.614N   |  P=0.200      P=0.092      P=0.044 *    P=0.095    |
|LOGISTIC REGRESSION    |  P=0.420      P=0.264N     P=0.352      P=0.641    |  P=0.229      P=0.060      P=0.044 *    P=0.125    |
|COCHRAN-ARMITAGE       |  P=0.431                                           |  P=0.161                                           |
|FISHER EXACT           |               P=0.340N     P=0.372      P=0.641N   |               P=0.063      P=0.037 *    P=0.102    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  18
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 34/60 (57%)  39/60 (65%)  34/60 (57%)  27/60 (45%) | 23/60 (38%)  26/60 (43%)  27/60 (45%)  19/60 (32%) |
|ADJUSTED (b)           |  70.5%        77.8%        73.1%        56.0%      |  52.7%        63.1%        59.5%        43.2%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   3/9 (33%)    1/9 (11%)  |  1/9 (11%)    0/8 (0%)     2/9 (22%)    0/6 (0%)   |
|TERMINAL (d)           | 25/39 (64%)  35/46 (76%)  26/38 (68%)  21/42 (50%) | 18/38 (47%)  20/35 (57%)  22/40 (55%)  18/43 (42%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      409          456 (I)   |   457 (I)      598          457 (I)      728       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.058N     P=0.553N     P=0.500      P=0.101N   |  P=0.069N     P=0.247      P=0.365      P=0.152N   |
|INCIDENTAL TUMOR       |  P=0.045N*    P=0.248      P=0.571N     P=0.143N   |  P=0.147N     P=0.270      P=0.283      P=0.270N   |
|LOGISTIC REGRESSION    |  P=0.052N     P=0.273      P=0.544      P=0.121N   |  P=0.100N     P=0.320      P=0.321      P=0.182N   |
|COCHRAN-ARMITAGE       |  P=0.052N                                          |  P=0.205N                                          |
|FISHER EXACT           |               P=0.227      P=0.573N     P=0.137N   |               P=0.355      P=0.289      P=0.283N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/60 (35%)  23/60 (38%)  25/60 (42%)  21/60 (35%) | 18/60 (30%)  23/60 (38%)  22/60 (37%)  22/60 (37%) |
|ADJUSTED (b)           |  47.1%        46.9%        49.8%        41.4%      |  39.6%        48.1%        45.8%        44.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     2/9 (22%)  |  0/9 (0%)     1/8 (13%)    0/9 (0%)     0/6 (0%)   |
|TERMINAL (d)           | 16/39 (41%)  20/46 (43%)  13/38 (34%)  13/42 (31%) | 11/38 (29%)  11/35 (31%)  14/40 (35%)  16/43 (37%) |
|FIRST INCIDENCE (DAYS) |   595          619          409          456 (I)   |   461          457 (I)      548          418       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.519N     P=0.488N     P=0.278      P=0.509N   |  P=0.514N     P=0.198      P=0.366      P=0.458    |
|INCIDENTAL TUMOR       |  P=0.461N     P=0.463      P=0.348      P=0.412N   |  P=0.225      P=0.327      P=0.290      P=0.292    |
|LOGISTIC REGRESSION    |  P=0.484N     P=0.326      P=0.275      P=0.566    |  P=0.165      P=0.186      P=0.189      P=0.332    |
|COCHRAN-ARMITAGE       |  P=0.518N                                          |  P=0.316                                           |
|FISHER EXACT           |               P=0.425      P=0.287      P=0.576N   |               P=0.221      P=0.281      P=0.281    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 05                                                 PAGE  19
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   UNTREATD     0.125%       0.25%        0.5%      |   UNTREATD     0.125%       0.25%        0.5%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/60 (67%)  46/60 (77%)  45/60 (75%)  39/60 (65%) | 33/60 (55%)  42/60 (70%)  38/60 (63%)  33/60 (55%) |
|ADJUSTED (b)           |  81.5%        88.4%        84.7%        74.8%      |  67.2%        83.9%        74.4%        65.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   3/9 (33%)    3/9 (33%)  |  1/9 (11%)    1/8 (13%)    2/9 (22%)    0/6 (0%)   |
|TERMINAL (d)           | 30/39 (77%)  40/46 (87%)  30/38 (79%)  29/42 (69%) | 22/38 (58%)  27/35 (77%)  27/40 (68%)  26/43 (60%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      409          456 (I)   |   457 (I)      457 (I)      457 (I)       82       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.358N     P=0.560N     P=0.200      P=0.375N   |  P=0.120N     P=0.058      P=0.359      P=0.333N   |
|INCIDENTAL TUMOR       |  P=0.358N     P=0.121      P=0.213      P=0.493N   |  P=0.365N     P=0.063      P=0.208      P=0.542N   |
|LOGISTIC REGRESSION    |  P=0.331N     P=0.091      P=0.159      P=0.520N   |  P=0.247N     P=0.033 *    P=0.154      P=0.515N   |
|COCHRAN-ARMITAGE       |  P=0.333N                                          |  P=0.344N                                          |
|FISHER EXACT           |               P=0.156      P=0.211      P=0.500N   |               P=0.066      P=0.229      P=0.573N   |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).