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TDMS Study 05217-03 Pathology Tables

NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 06:47:05




       Facility:  Southern Research Institute

       Chemical CAS #:  1948-33-0

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70           70           70           70                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                40           31           41           33           36                        
    Natural Death                                     10            7            8            9            7                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           22           11           16           17                        
  Other                                                                                       2                                     

  Animals Examined Microscopically                    70           70           70           68           70                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (70)         (70)         (69)         (66)         (69)                      
   Intestine Large, Rectum                            (69)         (70)         (69)         (67)         (69)                      
   Intestine Large, Cecum                             (70)         (70)         (70)         (67)         (70)                      
   Intestine Small, Duodenum                          (69)         (70)         (70)         (67)         (70)                      
      Carcinoma                                                                               1 (1%)                                
   Intestine Small, Jejunum                           (69)         (70)         (69)         (66)         (70)                      
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Ileum                             (70)         (70)         (68)         (67)         (68)                      
      Leiomyosarcoma                                                                          1 (1%)                                
   Liver                                              (70)         (70)         (70)         (68)         (70)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (1%)                                                          
      Hepatocellular Adenoma                                                     1 (1%)       2 (3%)       1 (1%)                   
      Hepatocellular Adenoma, Multiple                                                                     1 (1%)                   
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
   Mesentery                                          (11)         (5)          (13)         (10)         (7)                       
      Sarcoma Stromal, Metastatic, Uterus              1 (9%)                                                                       
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (70)         (70)         (70)         (67)         (69)                      
      Sarcoma Stromal, Metastatic, Uterus              1 (1%)                                                                       
   Salivary Glands                                    (70)         (70)         (70)         (68)         (70)                      
      Carcinoma                                                     1 (1%)                                                          
   Stomach, Forestomach                               (70)         (70)         (70)         (67)         (69)                      
      Squamous Cell Papilloma                                                                 1 (1%)                                
   Stomach, Glandular                                 (70)         (70)         (70)         (67)         (70)                      
   Tongue                                             (1)          (1)          (1)          (4)          (1)                       
      Squamous Cell Carcinoma                                                                 1 (25%)                               
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)     1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (70)         (70)         (68)         (70)                      
      Schwannoma Benign                                                          1 (1%)                    1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (70)         (70)         (68)         (70)                      
      Adenoma                                          4 (6%)                    1 (1%)                                             
   Adrenal Medulla                                    (70)         (70)         (70)         (68)         (70)                      
      Pheochromocytoma Malignant                                    1 (1%)                                 1 (1%)                   
      Pheochromocytoma Benign                          2 (3%)       2 (3%)       2 (3%)       1 (1%)       3 (4%)                   
   Islets, Pancreatic                                 (70)         (70)         (69)         (67)         (69)                      
      Adenoma                                          2 (3%)       1 (1%)       1 (1%)       3 (4%)       2 (3%)                   
      Carcinoma                                                                               1 (1%)                                
   Parathyroid Gland                                  (62)         (64)         (65)         (63)         (62)                      
      Adenoma                                          2 (3%)       1 (2%)                                 1 (2%)                   
      Carcinoma, Metastatic, Thyroid Gland                                                                 1 (2%)                   
   Pituitary Gland                                    (70)         (69)         (70)         (67)         (70)                      
      Pars Distalis, Adenoma                          26 (37%)     31 (45%)     27 (39%)     34 (51%)     28 (40%)                  
      Pars Distalis, Carcinoma                         2 (3%)       2 (3%)       1 (1%)       1 (1%)       3 (4%)                   
   Thyroid Gland                                      (70)         (69)         (70)         (67)         (70)                      
      C-Cell, Adenoma                                  7 (10%)      6 (9%)       7 (10%)      7 (10%)      6 (9%)                   
      C-Cell, Carcinoma                                1 (1%)       2 (3%)                    2 (3%)       1 (1%)                   
      Follicular Cell, Adenoma                                                                1 (1%)                                
      Follicular Cell, Carcinoma                       1 (1%)       1 (1%)                    1 (1%)       2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (68)         (69)         (69)         (68)         (70)                      
      Adenoma                                          6 (9%)       3 (4%)       6 (9%)       5 (7%)       6 (9%)                   
      Adenoma, Multiple                                             1 (1%)                                 1 (1%)                   
      Carcinoma                                        6 (9%)       1 (1%)       4 (6%)       5 (7%)       8 (11%)                  
      Carcinoma, Multiple                                           1 (1%)                                                          
   Ovary                                              (70)         (70)         (70)         (67)         (70)                      
      Carcinoma                                                                               1 (1%)                                
      Granulosa Cell Tumor Malignant                                             1 (1%)                                             
      Granulosa Cell Tumor Benign                      1 (1%)                    1 (1%)                    1 (1%)                   
   Uterus                                             (70)         (70)         (70)         (68)         (70)                      
      Adenoma                                                                                 1 (1%)       1 (1%)                   
      Carcinoma                                                                                            1 (1%)                   

                                                             Page   3                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyoma                                        1 (1%)                    1 (1%)       1 (1%)                                
      Polyp Stromal                                    6 (9%)       9 (13%)     12 (17%)      5 (7%)       9 (13%)                  
      Polyp Stromal, Multiple                          1 (1%)                                                                       
      Sarcoma Stromal                                  2 (3%)       1 (1%)       1 (1%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (70)         (70)         (67)         (70)                      
   Lymph Node                                         (20)         (14)         (24)         (19)         (18)                      
      Pancreatic, Carcinoma, Metastatic, Ovary                                                1 (5%)                                
   Lymph Node, Mandibular                             (69)         (70)         (70)         (65)         (70)                      
   Lymph Node, Mesenteric                             (68)         (69)         (70)         (65)         (70)                      
      Carcinoma, Metastatic, Ovary                                                            1 (2%)                                
   Spleen                                             (70)         (70)         (70)         (67)         (70)                      
      Hemangiosarcoma                                  1 (1%)                                                                       
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
   Thymus                                             (66)         (66)         (70)         (67)         (67)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Thymoma Malignant                                                                       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (70)         (70)         (69)         (68)         (70)                      
      Adenoma                                          3 (4%)       3 (4%)                    1 (1%)       2 (3%)                   
      Carcinoma                                        8 (11%)      1 (1%)       6 (9%)       2 (3%)       3 (4%)                   
      Carcinoma, Multiple                                                                                  1 (1%)                   
      Fibroadenoma                                    28 (40%)     21 (30%)     16 (23%)     25 (37%)     20 (29%)                  
      Fibroadenoma, Multiple                          15 (21%)      2 (3%)      17 (25%)      9 (13%)      7 (10%)                  
   Skin                                               (70)         (69)         (70)         (67)         (70)                      
      Basal Cell Carcinoma                             1 (1%)                    1 (1%)                                             
      Keratoacanthoma                                               1 (1%)                    1 (1%)                                
      Squamous Cell Papilloma                                                                              2 (3%)                   
      Subcutaneous Tissue, Fibroma                     3 (4%)       2 (3%)       2 (3%)       1 (1%)       1 (1%)                   
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (1%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                                 1 (1%)       1 (1%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (1%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                                                 1 (1%)                   
      Subcutaneous Tissue, Lipoma                      1 (1%)                                                                       
      Subcutaneous Tissue, Sarcoma                                                                         1 (1%)                   
      Subcutaneous Tissue, Schwannoma Benign                        1 (1%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant                                                            1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (70)         (69)         (68)         (70)                      
      Osteosarcoma                                                                            1 (1%)                                
   Skeletal Muscle                                    (1)          (1)          (1)          (1)          (1)                       
      Fibrous Histiocytoma, Metastatic, Skin                        1 (100%)                                                        
      Sarcoma                                                                                              1 (100%)                 
      Sarcoma Stromal, Metastatic, Uterus              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (70)         (70)         (68)         (70)                      
      Carcinoma, Metastatic, Mammary Gland                                                                 1 (1%)                   
      Carcinoma, Metastatic, Pituitary Gland                        1 (1%)                                 1 (1%)                   
      Oligodendroglioma Malignant                      1 (1%)                                                                       
   Spinal Cord                                        (2)          (1)          (2)          (3)          (4)                       
      Astrocytoma Malignant                                                                                1 (25%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (70)         (70)         (68)         (70)                      
      Alveolar/Bronchiolar Adenoma                     2 (3%)                    2 (3%)       1 (1%)       1 (1%)                   
      Alveolar/Bronchiolar Carcinoma                                             1 (1%)                                             
      Carcinoma, Metastatic, Ovary                                                            1 (1%)                                
      Carcinoma, Metastatic, Thyroid Gland                                                                 1 (1%)                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (1%)                                                          
   Nose                                               (70)         (70)         (70)         (68)         (70)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)         (70)         (67)         (70)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (1%)                                                          
      Sarcoma Stromal, Metastatic, Uterus              1 (1%)                                                                       
      Renal Tubule, Adenoma                            1 (1%)                                                                       
   Urinary Bladder                                    (69)         (70)         (70)         (68)         (69)                      

                                                             Page   5                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Papilloma                                                                                            1 (1%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(70)        *(70)        *(70)        *(68)        *(70)                      
      Leukemia Mononuclear                            27 (39%)     25 (36%)     33 (47%)     22 (32%)     27 (39%)                  
      Mesothelioma Malignant                           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          54          59          56          59                           
     Total Primary Neoplasms                          164         121         147         145         148                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 52          45          51          49          50                           
     Total Benign Neoplasms                           112          84          99         100          95                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          32          39          38          38                           
     Total Malignant Neoplasms                         52          37          48          45          53                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                       2           4                           
     Total Metastatic Neoplasm                          5           6                       5           4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70           70           70           70                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                48           41           51           50           42                        
    Natural Death                                      4            7            2            7            4                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8           12            7            1           14                        
  Other                                                                                       2                                     

  Animals Examined Microscopically                    70           70           70           68           70                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (68)         (70)         (68)         (68)         (70)                      
      Leiomyosarcoma                                                             1 (1%)                                             
   Intestine Large, Rectum                            (69)         (68)         (70)         (68)         (69)                      
      Carcinoma                                                                               1 (1%)                                
   Intestine Large, Cecum                             (70)         (70)         (68)         (68)         (70)                      
   Intestine Small, Duodenum                          (69)         (70)         (70)         (68)         (70)                      
   Intestine Small, Jejunum                           (70)         (69)         (70)         (67)         (70)                      
      Carcinoma                                                                               1 (1%)                                
   Intestine Small, Ileum                             (70)         (69)         (69)         (68)         (69)                      
      Leiomyoma                                                                  1 (1%)                                             
   Liver                                              (70)         (70)         (70)         (68)         (70)                      
      Hemangiosarcoma                                               1 (1%)                                                          
      Hepatocellular Carcinoma                                                                             2 (3%)                   
      Hepatocellular Adenoma                           4 (6%)       1 (1%)       4 (6%)                    3 (4%)                   
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (1%)                                             
      Osteosarcoma, Metastatic, Mesentery                                                     1 (1%)                                
   Mesentery                                          (20)         (15)         (11)         (7)          (16)                      
      Histiocytic Sarcoma                              1 (5%)                                                                       
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (9%)                                             
      Osteosarcoma                                                                            1 (14%)                               
      Schwannoma Malignant                             1 (5%)                                                                       
   Oral Mucosa                                        (1)                       (2)          (2)                                    
      Squamous Cell Carcinoma                          1 (100%)                  1 (50%)      2 (100%)                              
      Squamous Cell Papilloma                                                    1 (50%)                                            
   Pancreas                                           (70)         (70)         (69)         (68)         (70)                      
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (1%)                                             

                                                             Page   8                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Mixed Tumor Benign                                            1 (1%)                                                          
      Acinus, Adenoma                                  3 (4%)                                 1 (1%)                                
   Salivary Glands                                    (70)         (70)         (70)         (68)         (70)                      
      Carcinoma                                                                               1 (1%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (1%)                                
   Stomach, Forestomach                               (70)         (70)         (70)         (68)         (69)                      
      Squamous Cell Papilloma                                       2 (3%)                    1 (1%)       1 (1%)                   
   Stomach, Glandular                                 (70)         (70)         (69)         (68)         (70)                      
   Tongue                                             (1)          (2)          (2)          (1)          (4)                       
      Squamous Cell Carcinoma                          1 (100%)     1 (50%)                                                         
      Squamous Cell Papilloma                                                                              2 (50%)                  
   Tooth                                              (1)          (1)                       (2)          (1)                       
      Odontoma                                                                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (70)         (70)         (68)         (70)                      
      Schwannoma Malignant                             1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (70)         (70)         (68)         (70)                      
      Adenoma                                          1 (1%)       1 (1%)                                 1 (1%)                   
   Adrenal Medulla                                    (70)         (70)         (69)         (68)         (70)                      
      Pheochromocytoma Malignant                       1 (1%)       1 (1%)       3 (4%)       1 (1%)       3 (4%)                   
      Pheochromocytoma Complex                                      1 (1%)                                                          
      Pheochromocytoma Benign                         13 (19%)     11 (16%)     16 (23%)     11 (16%)     11 (16%)                  
      Pheochromocytoma Benign, Multiple                1 (1%)       1 (1%)       4 (6%)       4 (6%)       1 (1%)                   
   Islets, Pancreatic                                 (70)         (70)         (69)         (68)         (70)                      
      Adenoma                                          5 (7%)       2 (3%)       2 (3%)       1 (1%)       3 (4%)                   
      Carcinoma                                        1 (1%)                                                                       
   Pituitary Gland                                    (70)         (69)         (68)         (66)         (70)                      
      Pars Distalis, Adenoma                          19 (27%)     19 (28%)     16 (24%)     17 (26%)      6 (9%)                   
      Pars Distalis, Carcinoma                                      1 (1%)       1 (1%)       1 (2%)       1 (1%)                   
   Thyroid Gland                                      (70)         (70)         (70)         (68)         (70)                      
      C-Cell, Adenoma                                  5 (7%)       5 (7%)       2 (3%)       2 (3%)       4 (6%)                   
      C-Cell, Carcinoma                                             1 (1%)       1 (1%)                    2 (3%)                   
      Follicular Cell, Adenoma                                                   1 (1%)       1 (1%)                                
      Follicular Cell, Carcinoma                                                                           3 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                    (1)          (3)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (70)         (70)         (67)         (70)                      
   Preputial Gland                                    (70)         (70)         (70)         (68)         (70)                      
      Adenoma                                          5 (7%)                    3 (4%)       6 (9%)       3 (4%)                   
      Carcinoma                                        2 (3%)                    2 (3%)       1 (1%)       5 (7%)                   
      Carcinoma, Multiple                                                                     1 (1%)                                
   Prostate                                           (70)         (70)         (70)         (68)         (70)                      
      Adenoma                                          2 (3%)       3 (4%)       2 (3%)       1 (1%)       1 (1%)                   
   Seminal Vesicle                                    (70)         (70)         (70)         (68)         (70)                      
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (1%)                                             
   Testes                                             (70)         (70)         (70)         (67)         (70)                      
      Bilateral, Interstitial Cell, Adenoma           42 (60%)     53 (76%)     40 (57%)     45 (67%)     50 (71%)                  
      Interstitial Cell, Adenoma                      13 (19%)      5 (7%)       9 (13%)     11 (16%)      9 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (70)         (70)         (68)         (70)                      
   Lymph Node                                         (33)         (37)         (37)         (36)         (35)                      
      Mediastinal, Osteosarcoma, Metastatic,                                                                                        
          Mesentery                                                                           1 (3%)                                
   Lymph Node, Mandibular                             (70)         (69)         (70)         (68)         (70)                      
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (1%)                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (1%)                                
   Lymph Node, Mesenteric                             (70)         (68)         (68)         (67)         (70)                      
      Hemangioma                                                                                           1 (1%)                   
   Spleen                                             (70)         (70)         (70)         (68)         (70)                      
      Fibroma                                          2 (3%)       1 (1%)       1 (1%)                                             
      Hemangiosarcoma                                               1 (1%)                                                          
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (1%)                                             
      Osteosarcoma, Metastatic, Mesentery                                                     1 (1%)                                
      Sarcoma                                          1 (1%)                                 1 (1%)       1 (1%)                   
   Thymus                                             (68)         (65)         (65)         (64)         (66)                      
      Thymoma Malignant                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (67)         (68)         (67)         (66)         (68)                      
      Adenoma                                          1 (1%)       1 (1%)                    1 (2%)                                
      Fibroadenoma                                     9 (13%)      6 (9%)       4 (6%)       4 (6%)       6 (9%)                   
      Fibroadenoma, Multiple                           1 (1%)                                              1 (1%)                   
   Skin                                               (70)         (70)         (70)         (67)         (70)                      
      Basal Cell Carcinoma                             1 (1%)                                                                       
      Hemangioma                                                    1 (1%)                                                          
      Keratoacanthoma                                  3 (4%)       2 (3%)       4 (6%)       4 (6%)       4 (6%)                   
      Keratoacanthoma, Multiple                        1 (1%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Tongue                   1 (1%)                                                          
      Squamous Cell Papilloma                          2 (3%)       1 (1%)       1 (1%)                    2 (3%)                   
      Squamous Cell Papilloma, Multiple                                          1 (1%)                                             
      Trichoepithelioma                                2 (3%)       1 (1%)       1 (1%)                    1 (1%)                   
      Sebaceous Gland, Adenoma                         1 (1%)                    1 (1%)                                             
      Subcutaneous Tissue, Fibroma                     3 (4%)       7 (10%)      8 (11%)      6 (9%)       6 (9%)                   
      Subcutaneous Tissue, Fibroma, Multiple           1 (1%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)       3 (4%)       1 (1%)       1 (1%)       1 (1%)                   
      Subcutaneous Tissue, Hemangioma                  1 (1%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (1%)                                                                       
      Subcutaneous Tissue, Schwannoma Benign           1 (1%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (1%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (70)         (70)         (68)         (70)                      
      Osteosarcoma                                                                            1 (1%)                                
   Skeletal Muscle                                                              (2)          (2)                                    
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (50%)                                            
      Osteosarcoma, Metastatic, Mesentery                                                     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (70)         (70)         (68)         (70)                      
      Astrocytoma Malignant                            1 (1%)                    1 (1%)                                             
      Carcinoma, Metastatic, Pituitary Gland                        1 (1%)                                                          
      Oligodendroglioma Malignant                      1 (1%)                                                                       
   Spinal Cord                                        (2)                       (3)          (1)          (1)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  11                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (70)         (70)         (68)         (70)                      
      Alveolar/Bronchiolar Adenoma                     3 (4%)       2 (3%)       2 (3%)       1 (1%)       1 (1%)                   
      Alveolar/Bronchiolar Carcinoma                                3 (4%)                                 1 (1%)                   
      Carcinoma, Metastatic, Salivary Glands                                                  1 (1%)                                
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (1%)                                
   Nose                                               (70)         (70)         (70)         (68)         (70)                      
      Squamous Cell Carcinoma                                                    1 (1%)                                             
      Squamous Cell Papilloma                          1 (1%)                                                                       
   Pleura                                                                                    (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (1)          (1)                                    
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Eye                                                (4)          (4)          (2)          (1)          (2)                       
      Carcinoma, Metastatic, Salivary Glands                                                  1 (100%)                              
      Schwannoma Malignant                                          1 (25%)                                                         
   Zymbal's Gland                                     (2)          (1)          (1)          (3)          (4)                       
      Adenoma                                                                                              1 (25%)                  
      Carcinoma                                        2 (100%)     1 (100%)     1 (100%)     3 (100%)     3 (75%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)         (70)         (68)         (70)                      
      Lipoma                                           1 (1%)                                                                       
      Osteosarcoma, Metastatic, Mesentery                                                     1 (1%)                                
      Renal Tubule, Adenoma                            2 (3%)                                 1 (1%)       1 (1%)                   
      Transitional Epithelium, Carcinoma               1 (1%)                                                                       
   Urinary Bladder                                    (70)         (70)         (70)         (68)         (70)                      
      Papilloma                                                                               1 (1%)       1 (1%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(70)        *(70)        *(70)        *(68)        *(70)                      
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leukemia Mononuclear                            39 (56%)     45 (64%)     47 (67%)     40 (59%)     32 (46%)                  
      Lymphoma Malignant                               1 (1%)                                                                       
      Mesothelioma Malignant                           1 (1%)                                 1 (1%)       3 (4%)                   
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  12                                                               
NTP Experiment-Test: 05217-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 06:47:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.0%         0.125%       0.25%        0.5%                         
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          60          59          57          60                           
     Total Primary Neoplasms                          207         186         185         178         179                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 60          59          56          56          59                           
     Total Benign Neoplasms                           148         126         125         120         120                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              51          51          53          50          47                           
     Total Malignant Neoplasms                         59          60          60          58          59                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           1           5           2                           
     Total Metastatic Neoplasm                                      2           6          11           2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  13                                                               
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