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https://ntp.niehs.nih.gov/go/4625

TDMS Study 05706-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


NTP Experiment-Test: 05706-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 23:48:55




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           14           16                                                  
    Dead                                               5            3            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           32           33                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (8)          (50)                                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (8)          (50)                                                
      Mineralization                                                1 (13%)                                                         
      Parasite Metazoan                                4 (8%)                                                                       
   Intestine Large, Rectum                            (49)         (8)          (50)                                                
      Mineralization                                                1 (13%)                                                         
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (42)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       7 (14%)                                            
      Congestion                                       2 (4%)       3 (7%)                                                          
      Cytologic Alterations                            1 (2%)       3 (7%)       3 (6%)                                             
      Cytologic Alterations, Multiple                 23 (46%)     12 (29%)     22 (44%)                                            
      Fibrosis, Focal                                               1 (2%)                                                          
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                      16 (32%)     10 (24%)      8 (16%)                                            
      Hyperplasia, Focal                               5 (10%)      4 (10%)      4 (8%)                                             
      Hyperplasia, Multifocal                                       2 (5%)                                                          
      Inflammation, Chronic                           13 (26%)     12 (29%)     13 (26%)                                            
      Mitotic Alteration                               1 (2%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                                                       
      Pigmentation                                                               1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia                          19 (38%)     14 (33%)     16 (32%)                                            
      Centrilobular, Necrosis                          1 (2%)       2 (5%)       1 (2%)                                             
      Centrilobular, Vacuolization Cytoplasmic         5 (10%)      1 (2%)       4 (8%)                                             
   Mesentery                                          (2)          (2)          (3)                                                 
      Hyperplasia, Lymphoid                                                      1 (33%)                                            
      Fat, Necrosis                                    2 (100%)     2 (100%)     2 (67%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (49)         (8)          (50)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Acinus, Atrophy, Diffuse                         1 (2%)                                                                       
      Acinus, Atrophy, Focal                          13 (27%)      1 (13%)     23 (46%)                                            
      Acinus, Hyperplasia, Focal                                                 1 (2%)                                             
      Artery, Inflammation, Chronic                                              2 (4%)                                             
      Artery, Inflammation, Subacute                                             1 (2%)                                             
   Pharynx                                                                      (1)                                                 
      Palate, Inflammation, Acute                                                1 (100%)                                           
   Salivary Glands                                    (49)         (8)          (50)                                                
      Atrophy, Focal                                   1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
   Stomach, Forestomach                               (50)         (10)         (50)                                                
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Inflammation, Chronic                                         1 (10%)                                                         
      Ulcer                                                         1 (10%)      4 (8%)                                             
      Epithelium, Hyperplasia                          2 (4%)                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (10)         (50)                                                
      Edema                                            1 (2%)                                                                       
      Erosion                                          1 (2%)       2 (20%)      1 (2%)                                             
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)       1 (10%)                                                         
      Pigmentation                                     2 (4%)                                                                       
      Ulcer                                                                      2 (4%)                                             
   Tongue                                             (2)                                                                           
      Epithelium, Hyperplasia                          2 (100%)                                                                     
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)          (1)                                                 
      Aorta, Mineralization                                         1 (100%)                                                        
      Artery, Inflammation, Chronic                                              1 (100%)                                           
   Heart                                              (50)         (8)          (50)                                                
      Cardiomyopathy                                  25 (50%)      4 (50%)     28 (56%)                                            
      Mineralization                                   1 (2%)       1 (13%)                                                         
      Atrium, Thrombosis                               2 (4%)                    4 (8%)                                             
      Myocardium, Necrosis                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)                                                
      Amyloid Deposition                                            1 (2%)       1 (2%)                                             
      Congestion                                       2 (4%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Focal                                                         1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)                                                          
      Necrosis, Focal                                  2 (4%)       2 (4%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 6 (12%)      8 (16%)      9 (18%)                                            
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Hyperplasia                                      9 (18%)      5 (10%)      7 (14%)                                            
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (8)          (50)                                                
      Hyperplasia                                                                2 (4%)                                             
   Parathyroid Gland                                  (47)         (7)          (48)                                                
      Hyperplasia                                                   1 (14%)                                                         
   Pituitary Gland                                    (50)         (37)         (49)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Angiectasis                      15 (30%)      9 (24%)     15 (31%)                                            
      Pars Distalis, Cyst                              7 (14%)      2 (5%)       3 (6%)                                             
      Pars Distalis, Cyst, Multiple                                              1 (2%)                                             
      Pars Distalis, Hyperplasia                       9 (18%)      6 (16%)      9 (18%)                                            
      Pars Distalis, Infarct                                                     1 (2%)                                             
      Pars Distalis, Pigmentation                                   1 (3%)                                                          
      Pars Nervosa, Cyst                               1 (2%)                                                                       
      Pars Nervosa, Ectopic Tissue                                  1 (3%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (10)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              8 (16%)                   5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (13)         (46)                                                
      Dilatation                                       1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Acute                              6 (13%)      1 (8%)       2 (4%)                                             
   Ovary                                              (50)         (8)          (50)                                                
      Cyst                                            10 (20%)                   3 (6%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                                1 (13%)                                                         
   Uterus                                             (50)         (22)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Angiectasis                                                                1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Cervix, Inflammation, Acute                                   1 (5%)                                                          
      Endometrium, Hyperplasia, Cystic                 5 (10%)      3 (14%)      4 (8%)                                             
   Vagina                                             (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (8)          (50)                                                
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Hyperplasia                                                   2 (25%)      1 (2%)                                             
   Lymph Node                                         (50)         (27)         (49)                                                
      Axillary, Hemorrhage                                                       1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                                            2 (4%)                                             
      Bronchial, Hemorrhage                            1 (2%)                                                                       
      Iliac, Cyst                                      1 (2%)       1 (4%)                                                          
      Iliac, Hemorrhage                                             1 (4%)                                                          
      Iliac, Hyperplasia, Lymphoid                                  2 (7%)                                                          
      Inguinal, Hyperplasia, Lymphoid                               1 (4%)                                                          
      Lymphocyte, Mandibular, Necrosis                                           1 (2%)                                             
      Mandibular, Cyst                                 4 (8%)                    1 (2%)                                             
      Mandibular, Hemorrhage                           5 (10%)                   4 (8%)                                             
      Mediastinal, Hemorrhage                          7 (14%)      7 (26%)     14 (29%)                                            
      Mediastinal, Pigmentation                        1 (2%)                    1 (2%)                                             
      Mediastinal, Lymphocyte, Necrosis                                          1 (2%)                                             
      Prefemoral, Hyperplasia, Lymphoid                             1 (4%)                                                          
   Lymph Node, Mesenteric                             (50)         (8)          (49)                                                
      Hemorrhage                                       4 (8%)       1 (13%)      4 (8%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Spleen                                             (49)         (22)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Fibrosis, Focal                                  1 (2%)       1 (5%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       3 (14%)      2 (4%)                                             
      Hemorrhage                                                    1 (5%)                                                          
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Necrosis, Focal                                  1 (2%)       1 (5%)                                                          
      Pigmentation                                     2 (4%)       2 (9%)       1 (2%)                                             
   Thymus                                             (48)         (8)          (49)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (47)         (50)                                                
      Dilatation                                       6 (12%)      4 (9%)       1 (2%)                                             
      Hyperplasia                                      4 (8%)       1 (2%)       3 (6%)                                             
   Skin                                               (50)         (8)          (50)                                                
      Cyst                                             1 (2%)                                                                       
      Subcutaneous Tissue, Abscess                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
      Subcutaneous Tissue, Thrombosis, Multiple        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (8)          (50)                                                
      Osteoporosis                                                  1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (8)          (50)                                                
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (33)                      (38)                                                
      Inflammation, Chronic                            1 (3%)                                                                       
   Lung                                               (50)         (29)         (50)                                                
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                      12 (24%)     13 (45%)      4 (8%)                                             
      Hyperplasia, Adenomatous                         2 (4%)       3 (10%)      1 (2%)                                             
      Infiltration Cellular, Histiocyte                7 (14%)      2 (7%)       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Interstitium, Inflammation, Chronic              3 (6%)                   10 (20%)                                            
   Nose                                               (49)         (8)          (50)                                                
      Metaplasia, Squamous                                          1 (13%)                                                         
      Nasolacrimal Duct, Fungus                        1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)       1 (13%)      1 (2%)                                             
      Sinus, Foreign Body                              1 (2%)                                                                       
      Sinus, Fungus                                    1 (2%)       1 (13%)      1 (2%)                                             
      Sinus, Inflammation, Acute                       3 (6%)       2 (25%)      1 (2%)                                             
      Turbinate, Inflammation, Chronic                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (5)          (2)                                                 
      Cornea, Inflammation, Chronic                                 1 (20%)                                                         
      Iris, Inflammation, Chronic                      1 (33%)                                                                      
      Lens Capsule, Cataract                           1 (33%)      5 (100%)     2 (100%)                                           
      Retina, Atrophy                                  1 (33%)      5 (100%)     2 (100%)                                           
      Sclera, Metaplasia, Osseous                      1 (33%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Fibrosis, Focal                                               1 (2%)                                                          
      Inflammation, Acute                                                        3 (6%)                                             
      Nephropathy                                     46 (92%)     47 (94%)     47 (94%)                                            
      Pigmentation                                     1 (2%)       3 (6%)       3 (6%)                                             
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Inflammation, Acute                      1 (2%)       1 (2%)                                                          
      Pelvis, Inflammation, Subacute                   1 (2%)                                                                       
      Pelvis, Mineralization                           8 (16%)     30 (60%)     37 (74%)                                            
      Pelvis, Epithelium, Hyperplasia                               1 (2%)                                                          
   Urinary Bladder                                    (50)         (9)          (50)                                                
      Hemorrhage                                                    1 (11%)                                                         
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          21           24           20                                                  
    Dead                                               7            6            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           20           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (15)         (48)                                                
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (7%)                                                          
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (47)         (14)         (49)                                                
      Mineralization                                                1 (7%)                                                          
      Parasite Metazoan                                4 (9%)                                                                       
   Intestine Large, Rectum                            (47)         (14)         (48)                                                
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Small, Duodenum                          (48)         (12)         (49)                                                
      Inflammation, Acute                                           1 (8%)                                                          
   Intestine Small, Jejunum                           (47)         (11)         (48)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (50)         (49)         (50)                                                
      Angiectasis                                     11 (22%)     16 (33%)     17 (34%)                                            
      Congestion                                       1 (2%)       4 (8%)       2 (4%)                                             
      Cyst                                             1 (2%)                                                                       
      Cytologic Alterations                            5 (10%)     13 (27%)      1 (2%)                                             
      Cytologic Alterations, Multiple                 11 (22%)      5 (10%)     12 (24%)                                            
      Fibrosis                                                      1 (2%)                                                          
      Fibrosis, Focal                                  2 (4%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       8 (16%)      4 (8%)       7 (14%)                                            
      Hyperplasia, Focal                              10 (20%)      8 (16%)      8 (16%)                                            
      Hyperplasia, Multifocal                                       1 (2%)       1 (2%)                                             
      Hyperplasia, Nodular                             3 (6%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis, Focal                                                            2 (4%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
      Bile Duct, Hyperplasia                          38 (76%)     39 (80%)     44 (88%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia, Cystic                                1 (2%)                                                          
      Centrilobular, Degeneration                      1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                    2 (4%)                                             
      Centrilobular, Vacuolization Cytoplasmic         2 (4%)       3 (6%)       6 (12%)                                            
      Periportal, Vacuolization Cytoplasmic            1 (2%)                                                                       
   Mesentery                                          (5)          (2)          (5)                                                 
      Inflammation, Acute                              1 (20%)                                                                      
      Inflammation, Chronic                            1 (20%)                                                                      
      Fat, Inflammation, Acute                         2 (40%)                                                                      
      Fat, Necrosis                                    1 (20%)      2 (100%)     1 (20%)                                            
   Pancreas                                           (49)         (16)         (49)                                                
      Accessory Spleen                                              1 (6%)                                                          
      Acinus, Atrophy, Diffuse                                                   2 (4%)                                             
      Acinus, Atrophy, Focal                          14 (29%)      1 (6%)      17 (35%)                                            
      Acinus, Hyperplasia, Focal                                                 1 (2%)                                             
      Artery, Inflammation, Chronic                    3 (6%)                                                                       
   Salivary Glands                                    (50)         (14)         (50)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Stomach, Forestomach                               (49)         (21)         (49)                                                
      Edema                                            1 (2%)       1 (5%)       1 (2%)                                             
      Erosion                                                       1 (5%)                                                          
      Inflammation, Acute                              1 (2%)       1 (5%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                   1 (2%)       1 (5%)                                                          
      Ulcer                                                         4 (19%)      1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Epithelium, Hyperplasia                                       3 (14%)      1 (2%)                                             
   Stomach, Glandular                                 (48)         (21)         (50)                                                
      Amyloid Deposition                                            1 (5%)                                                          
      Erosion                                          4 (8%)       5 (24%)      3 (6%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                   2 (4%)       1 (5%)                                                          
      Pigmentation                                                               1 (2%)                                             
      Ulcer                                            1 (2%)       1 (5%)       4 (8%)                                             
   Tongue                                                                       (3)                                                 
      Inflammation, Chronic                                                      1 (33%)                                            
      Epithelium, Hyperplasia                                                    2 (67%)                                            
   Tooth                                              (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (1)                                                              
      Aorta, Inflammation, Chronic                     1 (50%)                                                                      
      Aorta, Mineralization                            1 (50%)      1 (100%)                                                        
   Heart                                              (50)         (20)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Cardiomyopathy                                  38 (76%)     16 (80%)     40 (80%)                                            
      Mineralization                                                1 (5%)                                                          
      Atrium, Thrombosis                               6 (12%)      5 (25%)      4 (8%)                                             
      Endocardium, Thrombosis                                       1 (5%)                                                          
      Epicardium, Fibrosis, Focal                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Subacute                                        1 (2%)                                                          
      Necrosis, Focal                                                            1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 2 (4%)       2 (4%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (50)         (50)                                                
      Hyperplasia                                     17 (35%)     21 (42%)     13 (26%)                                            
   Islets, Pancreatic                                 (49)         (16)         (49)                                                
      Hyperplasia                                      4 (8%)       1 (6%)       3 (6%)                                             
   Parathyroid Gland                                  (49)         (15)         (45)                                                
      Hyperplasia                                      3 (6%)       1 (7%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Angiectasis                       3 (6%)       3 (6%)       2 (4%)                                             
      Pars Distalis, Cyst                              1 (2%)       2 (4%)       7 (14%)                                            
      Pars Distalis, Hyperplasia                       3 (6%)       9 (18%)      8 (16%)                                            
      Pars Nervosa, Ectopic Tissue                                  1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (18)         (50)                                                
      Cyst                                             2 (4%)                                                                       
      C-Cell, Hyperplasia                              5 (10%)                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (20)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
      Inflammation, Acute                             11 (22%)      2 (10%)      8 (16%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
   Prostate                                           (50)         (14)         (49)                                                
      Hyperplasia, Focal                               6 (12%)                   5 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Acute                             17 (34%)      1 (7%)       8 (16%)                                            
      Inflammation, Chronic                            2 (4%)                                                                       
   Seminal Vesicle                                    (48)         (37)         (47)                                                
      Atrophy                                         25 (52%)     15 (41%)     25 (53%)                                            
      Inflammation, Acute                                                        1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                         15 (30%)     14 (28%)     24 (48%)                                            
      Interstitial Cell, Hyperplasia                   2 (4%)       5 (10%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (14)         (50)                                                
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       5 (36%)      2 (4%)                                             
   Lymph Node                                         (50)         (33)         (50)                                                
      Axillary, Hyperplasia, Lymphoid                               1 (3%)                                                          
      Iliac, Cyst                                                   1 (3%)                                                          
      Inguinal, Cyst                                   1 (2%)                    1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  2 (4%)       1 (3%)       2 (4%)                                             
      Mandibular, Cyst                                 7 (14%)                   3 (6%)                                             
      Mandibular, Hemorrhage                                                     1 (2%)                                             
      Mandibular, Hyperplasia, Lymphoid                             1 (3%)       2 (4%)                                             
      Mediastinal, Cyst                                1 (2%)                                                                       
      Mediastinal, Hemorrhage                          9 (18%)      8 (24%)     10 (20%)                                            
      Mediastinal, Pigmentation                                                  3 (6%)                                             
      Pancreatic, Hemorrhage                                                     1 (2%)                                             
      Renal, Hemorrhage                                             1 (3%)                                                          
      Renal, Inflammation, Chronic                                               1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (18)         (50)                                                
      Cyst                                             1 (2%)       2 (11%)      1 (2%)                                             
      Edema                                            1 (2%)                    1 (2%)                                             
      Hemorrhage                                       3 (6%)       4 (22%)      1 (2%)                                             
   Spleen                                             (49)         (49)         (50)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Congestion                                       3 (6%)       1 (2%)       2 (4%)                                             
      Depletion Lymphoid                                                         1 (2%)                                             
      Fibrosis, Focal                                  8 (16%)      5 (10%)      7 (14%)                                            
      Hematopoietic Cell Proliferation                 2 (4%)       5 (10%)      5 (10%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Necrosis                                         2 (4%)       1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Capsule, Fibrosis, Focal                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (18)         (50)                                                
      Dilatation                                       1 (2%)       2 (11%)      2 (4%)                                             
      Hyperplasia                                                                1 (2%)                                             
   Skin                                               (49)         (21)         (50)                                                
      Cyst                                                          1 (5%)                                                          
      Edema                                            1 (2%)       1 (5%)                                                          
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Acute                              2 (4%)                                                                       
      Inflammation, Chronic                                         1 (5%)                                                          
      Epithelium, Lip, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (14)         (50)                                                
      Hyperostosis                                     1 (2%)                                                                       
      Osteomalacia                                     1 (2%)       1 (7%)                                                          
      Tarsal, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (50)                                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Thrombosis                                       2 (4%)                    6 (12%)                                            
      Thrombosis, Multiple                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (26)                      (27)                                                
      Inflammation, Subacute                           1 (4%)                                                                       
      Ulcer                                            1 (4%)                                                                       
   Lung                                               (50)         (30)         (50)                                                
      Congestion                                       1 (2%)       1 (3%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage                                       2 (4%)       1 (3%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Adenomatous                         4 (8%)       4 (13%)      2 (4%)                                             
      Infiltration Cellular, Histiocyte                4 (8%)       1 (3%)       1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
      Interstitium, Inflammation, Chronic              1 (2%)       2 (7%)       5 (10%)                                            
   Nose                                               (49)         (14)         (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05706-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                    2 (4%)                                             
      Sinus, Foreign Body                                           1 (7%)       2 (4%)                                             
      Sinus, Fungus                                    4 (8%)       2 (14%)      3 (6%)                                             
      Sinus, Inflammation, Acute                       8 (16%)      4 (29%)      9 (18%)                                            
      Turbinate, Inflammation, Chronic                 5 (10%)                                                                      
      Turbinate, Inflammation, Subacute                1 (2%)                                                                       
      Turbinate, Thrombosis                                         1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)                                                 
      Lens Capsule, Cataract                           2 (100%)                                                                     
      Retina, Atrophy                                  2 (100%)                                                                     
      Sclera, Metaplasia, Osseous                                                1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (45)         (50)                                                
      Cyst                                             3 (6%)       2 (4%)       3 (6%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis, Focal                                               1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Nephropathy                                     48 (96%)     42 (93%)     46 (92%)                                            
      Pigmentation                                                  1 (2%)                                                          
      Pelvis, Dilatation                                                         1 (2%)                                             
      Pelvis, Mineralization                           1 (2%)                    3 (6%)                                             
      Renal Tubule, Degeneration                       1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (50)         (14)         (49)                                                
      Hemorrhage                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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