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TDMS Study 05706-02 Pathology Tables

NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97
Route: DOSED FEED                                                                                                 Time: 07:53:32




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X        X     X  X        X        X              X  X              X|             
      Neoplastic Nodule                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leiomyosarcoma                       |                                                                          |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +  +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                         X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X        X                 X              X  X               |             
      Pheochromocytoma Benign              |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X                                                           X         |             
      Pars Distalis, Leukemia Mononuclear  |                   X  X                 X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      C-Cell, Adenoma                      |                                                       X                  |             
      C-Cell, Carcinoma                    |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +  M  +  M  +  +  +        +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                      X               |             
      Cervix, Carcinoma                    |                               X                                          |             
      Cervix, Leiomyosarcoma               |                                                                          |             
      Endometrium, Polyp Stromal           |    X           X        X                                X  X            |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Axillary, Leukemia Mononuclear       |                   X                                                      |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                  X                                       |             
      Iliac, Leukemia Mononuclear          |                   X                                   X                  |             
      Inguinal, Leukemia Mononuclear       |                   X                                   X                  |             
      Mandibular, Leukemia Mononuclear     |                   X                                   X  X               |             
      Mediastinal, Leukemia Mononuclear    |                   X                                                      |             
      Pancreatic, Leukemia Mononuclear     |                   X                                      X               |             
      Renal, Leukemia Mononuclear          |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X                                      X               |             
      Axillary, Mediastinal,               |                                                                          |             
          Adenocarcinoma, Metastatic, Skin |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X        X     X  X        X        X              X  X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  M  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                            X                                             |             
      Fibroadenoma                         | X                 X                 X                 X                  |             
      Fibroadenoma, Multiple               |                                                             X            |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Sebaceous Gland, Adenocarcinoma      |       X                                                                  |             
      Subcutaneous Tissue, Fibroma         |                                                                X         |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Glioma Benign                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +        +  +  +     +  +  +  +        +           +  +  +           +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Adenocarcinoma, Metastatic, Skin     |       X                                                                  |             
      Leukemia Mononuclear                 |             X     X  X        X        X              X  X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +     +                                                |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
      Squamous Cell Carcinoma              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X        X     X  X        X        X              X  X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 | X           X              X  X                 X        X               |             
      Neoplastic Nodule                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leiomyosarcoma                       |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X                                          |             
      Pheochromocytoma Benign              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Pars Distalis, Adenoma               |    X        X  X        X  X     X     X  X        X           X     X   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      C-Cell, Adenoma                      |                                              X                           |             
      C-Cell, Carcinoma                    |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  M  +  +|             
      Adenoma                              |                                        X        X              X         |             
      Bilateral, Adenoma                   | X                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Cervix, Carcinoma                    |                                                                          |             
      Cervix, Leiomyosarcoma               |                                                                          |             
      Endometrium, Polyp Stromal           | X     X                                X     X                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Iliac, Leukemia Mononuclear          | X                                                                        |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |             X                                                            |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Axillary, Mediastinal,               |                                                                          |             
          Adenocarcinoma, Metastatic, Skin |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 | X           X              X  X                 X        X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Thymoma Benign                       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Adenocarcinoma                       |                            X                                             |             
      Adenoma                              |                                                          X               |             
      Fibroadenoma                         |    X  X     X                                                        X   |             
      Fibroadenoma, Multiple               |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Sebaceous Gland, Adenocarcinoma      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Glioma Benign                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +        +  +  +  +           +     +  +  +     +     +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Adenocarcinoma, Metastatic, Skin     |                                                                          |             
      Leukemia Mononuclear                 | X           X                 X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
      Squamous Cell Carcinoma              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Leukemia Mononuclear                 | X           X              X  X                 X        X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |         16 |
      Neoplastic Nodule                    | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +     +  +  +  +  +                                             |  49        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |          X        X                                                      |         15 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +     +  +  +  +  +                                             |  49        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +     +  +  +  +  +                                             |  47        |
      Adenoma                              |                                                                          |          3 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Cervix, Carcinoma                    |                                                                          |          1 |
      Cervix, Leiomyosarcoma               |                            X                                             |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +     +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          3 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Leukemia Mononuclear     |                                                                          |          4 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Axillary, Mediastinal,               |                                                                          |            |
          Adenocarcinoma, Metastatic, Skin |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                         X                                                |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +     +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +     +  +  +  +  +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          2 |
      Fibroadenoma                         |                X                                                         |          9 |
      Fibroadenoma, Multiple               |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +     +  +  +  +  +                                             |  50        |
      Sebaceous Gland, Adenocarcinoma      |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Benign                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +     +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +     +  +  +  +  +                                             |  50        |
      Glioma Benign                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +        +     +     +  +                                                |  33        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +     +  +  +  +  +                                             |  50        |
      Adenocarcinoma, Metastatic, Skin     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +     +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Squamous Cell Carcinoma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +        +     +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |         16 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +        +  +  +  +  +  +  +  +  +     +  +     +  +        +  +|             
      Leukemia Mononuclear                 |    X                                            X  X     X              X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Pheochromocytoma Malignant           | X                                                                        |             
      Pheochromocytoma Benign              |                                              X              X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +        M                             +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +        +  +  +  +  +  +  +  +  +  +        +  +           +  +|             
      Pars Distalis, Adenoma               |          X           X           X     X  X           X  X               |             
      Pars Distalis, Leukemia Mononuclear  |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +        +                             +  +|             
      C-Cell, Carcinoma                    |                                                                         X|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                             +        +                             +  +|             
      Adenoma                              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +                          +        +              +  +           +  +|             
      Leiomyosarcoma                       |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
      Cervix, Squamous Cell Carcinoma      |                                                                          |             
      Endometrium, Polyp Stromal           | X                                                        X               |             
      Endometrium, Sarcoma Stromal         |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +              +           +  +  +  +     +     +     +  +        +  +|             
      Axillary, Leukemia Mononuclear       |                                                                         X|             
      Iliac, Leukemia Mononuclear          |                                                          X               |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
      Renal, Leukemia Mononuclear          |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +        +                             +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +                 +  +     +        +     +           +           +  +|             
      Leukemia Mononuclear                 |    X                                         X           X              X|             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +           +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X  X              X                 X     X     X        X               |             
      Fibroadenoma, Multiple               |                            X                 X        X                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +        +                             +   |             
      Astrocytoma Benign                   |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +                    +     +  +  +  +  +  +  +              +   |             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Leukemia Mononuclear                 |                                              X     X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                             +                          +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Leukemia Mononuclear                 |    X                                         X  X  X     X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +           +  +  +  +  +  +  +  +  +  +     +     +     +     +  +   |             
      Leukemia Mononuclear                 |                   X  X  X        X     X              X           X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +                 +     +  +              +           +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +                 +     +  +              +           +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                 +     +  +              +           +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                      X                                                   |             
      Pheochromocytoma Malignant           |                            X                                             |             
      Pheochromocytoma Benign              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +     +  +           +  +  +  +  +     +  +  +     +     +  +   |             
      Pars Distalis, Adenoma               |          X        X              X  X              X  X     X     X  X   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +                       +  +                          +   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +           M  +                    +  +              +           +   |             
      Adenoma                              |    X              X                                      X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +     +  +  +     +  +        +  +        +  +              +   |             
      Leiomyosarcoma                       |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Cervix, Squamous Cell Carcinoma      |                            X                                             |             
      Endometrium, Polyp Stromal           |          X        X        X  X                    X  X                  |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +  +  +     +        +  +  +     +  +     +           +   |             
      Axillary, Leukemia Mononuclear       |                      X                                                   |             
      Iliac, Leukemia Mononuclear          |                      X                                                   |             
      Inguinal, Leukemia Mononuclear       |                   X                                                      |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +                       +        +                    +   |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +     +  +  +  +        +     +  +                          +   |             
      Leukemia Mononuclear                 |                   X  X  X        X     X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +           +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                   X      |             
      Fibroadenoma                         |    X           X  X                                   X  X        X      |             
      Fibroadenoma, Multiple               |                                           X                              |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                       +  +                          +   |             
      Astrocytoma Benign                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +  +     +  +  +        +  +     +  +  +     +     +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                   X                    X                          X      |             
                                            __________________________________________________________________________|             
   Nose                                    |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Carcinoma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                   X  X  X        X     X              X           X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +  +  +  +  +                                             |  42        |
      Leukemia Mononuclear                 |                         X                                                |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                                                                        |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |             X                                                            |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +        +  +  +                                             |  37        |
      Pars Distalis, Adenoma               | X        X              X  X                                             |         20 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              +                                                         |  10        |
      C-Cell, Carcinoma                    |                X                                                         |          2 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                 +                                                      |  13        |
      Adenoma                              |                   X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                    +     +                                             |  22        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Cervix, Squamous Cell Carcinoma      |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          8 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                 +                                                      |  27        |
      Axillary, Leukemia Mononuclear       |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   8        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                       +                                                |  22        |
      Leukemia Mononuclear                 |                         X                                                |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +  +  +  +  +                                             |  47        |
      Adenocarcinoma                       | X           X                                                            |          2 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |             X     X     X  X                                             |         17 |
      Fibroadenoma, Multiple               |                                                                          |          4 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |   8        |
      Astrocytoma Benign                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +     +                                                      |  29        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +              +                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                    X        X           X           X|             
      Neoplastic Nodule                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +        +         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Pheochromocytoma Benign              |                            X                             X        X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                          X  X  X                                    |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  M     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Carcinoma                    |                         X                                            X  X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +     M  +  M  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                      X               |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                      X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Endometrium, Polyp Stromal           |    X     X              X                 X              X     X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         +        +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |          X                                                               |             
      Mandibular, Leukemia Mononuclear     |                                                 X                        |             
      Pancreatic, Leukemia Mononuclear     |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                    X        X           X           X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Thymoma Benign                       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X     X  X  X  X        X                          X  X        X|             
      Fibroadenoma, Multiple               |       X                             X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                             X            |             
      Subcutaneous Tissue, Fibrosarcoma    |                   X                                                      |             
      Subcutaneous Tissue, Lipoma          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Glioma Benign                        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +        +  +  +  +  +  +        +  +     +     +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
      Leukemia Mononuclear                 |          X        X                    X        X                        |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Adenoma                |                                           X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                      X                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                    X        X           X           X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X        X        X                    X  X                        |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Adenoma                              |                            X                                             |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Leukemia Mononuclear                 |                         X              X     X  X                        |             
      Pheochromocytoma Benign              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Pars Distalis, Adenoma               | X     X              X                    X                              |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Adenoma                      |    X                                                                 X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Carcinoma                    |                                  X        X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +        +     +  +  +     +     +  M  +  +  +  +  +  M     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Granulosa Cell Tumor Benign          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Endometrium, Polyp Stromal           |                X                       X  X        X        X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X        X        X              X     X  X  X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  M  +  +     +  +  +|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma                       | X     X                                                     X            |             
      Adenoma                              |                                                                         X|             
      Fibroadenoma                         |                                  X        X        X  X  X           X   |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Glioma Benign                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +        +     +     +     +     +  +        +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                         X                    X  X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X        X        X              X     X  X  X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |         12 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                X                                                         |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Pheochromocytoma Benign              |                      X                                                   |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               | X           X     X     X  X                                             |         13 |
      Pars Distalis, Adenoma, Multiple     |       X                                                                  |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      C-Cell, Adenoma                      |                         X                                                |          3 |
      C-Cell, Carcinoma                    |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Adenoma                              |          X           X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Granulosa Cell Tumor Benign          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Endometrium, Polyp Stromal           |                                                                          |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |             X        X                                                   |         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          3 |
      Adenoma                              | X                                                                        |          2 |
      Fibroadenoma                         |    X           X     X  X                                                |         19 |
      Fibroadenoma, Multiple               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                   X                                                      |          2 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Glioma Benign                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +  +     +  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |             X        X                                                   |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Adenoma, Papillary                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X                 X                       X     X  X   |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                     +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Mesothelioma Malignant               |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X        X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X                                                     X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Pheochromocytoma Malignant           |                                              X                           |             
      Pheochromocytoma Benign              |       X                       X        X     X     X                     |             
      Pheochromocytoma Benign, Multiple    |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X        X              X     X              X        X  X               |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                X                                            X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |          X  X                 X                       X                  |             
      Carcinoma                            | X                                                                        |             
      Leukemia Mononuclear                 |                X                                                         |             
      Bilateral, Carcinoma                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |             X                                                            |             
      Interstitial Cell, Adenoma           |                               X                          X               |             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X  X  X     X        X  X  X     X  X  X           X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Iliac, Leukemia Mononuclear          |                X                                                         |             
      Mandibular, Leukemia Mononuclear     |                X                                                         |             
      Mediastinal, Leukemia Mononuclear    |                X                    X                                    |             
      Pancreatic, Leukemia Mononuclear     |                X                    X                                    |             
      Renal, Leukemia Mononuclear          |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X                 X                             X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X     X  X                 X                       X     X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Fibroadenoma                         |                                                    X                     |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X                                                     X   |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +        +                    +  +                        |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X                 X                       X     X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
      External Ear, Squamous Cell Carcinoma|       X                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X                                                  X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X     X  X                 X                       X     X  X   |             
      Mesothelioma Malignant               |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
      Adenoma, Papillary                   |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X  X     X     X  X  X           X      |             
      Neoplastic Nodule                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                      +  +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                             +            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                X                 X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                X     X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     M  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                 X      |             
      Pheochromocytoma Malignant           |       X                                                                  |             
      Pheochromocytoma Benign              |          X        X                 X                 X              X   |             
      Pheochromocytoma Benign, Multiple    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Carcinoma                            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |       X        X  X  X                    X     X        X               |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      C-Cell, Adenoma                      |                                                 X                        |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Adenoma                              |    X     X                                X                              |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Bilateral, Carcinoma                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant               |                   X                                                      |             
      Interstitial Cell, Adenoma           |                X                                X                        |             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X     X  X  X  X     X  X  X           X  X           X  X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                   X      |             
      Mediastinal, Leukemia Mononuclear    |                                                                   X      |             
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X     X                          X                 X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X  X     X     X  X  X           X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X     X                                            X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  M  +|             
      Fibroadenoma                         |                                  X                          X            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +     +  +  +|             
      Keratoacanthoma                      |                                        X                             X   |             
      Squamous Cell Carcinoma              |                                           X                              |             
      Squamous Cell Papilloma              |                                                                         X|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X   |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                X                        |             
      Sarcoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +     +  +  +        +  +  +  +        +              +     +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |       X        X           X     X  X           X  X  X           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      External Ear, Squamous Cell Carcinoma|                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                                  X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                X                                                  X      |             
      Transitional Epithelium, Papilloma   |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X  X     X     X  X  X           X      |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +           +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +           +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +           +  +  +     +                                             |  48        |
      Adenoma, Papillary                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |    X           X  X        X                                             |         22 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +  +  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +           +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +           +  +  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A           +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                            X                                             |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +  +  +     +                                             |  48        |
      Leukemia Mononuclear                 |                   X                                                      |          4 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |    X                 X                                                   |         12 |
      Pheochromocytoma Benign, Multiple    | X                                                                        |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +     +                                             |  49        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +  +  +     +                                             |  49        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +  +  +     +                                             |  50        |
      Pars Distalis, Adenoma               |                X  X                                                      |         16 |
      Pars Distalis, Adenoma, Multiple     | X                                                                        |          1 |
      Pars Distalis, Leukemia Mononuclear  |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +  +     +                                             |  49        |
      C-Cell, Adenoma                      |                      X                                                   |          2 |
      C-Cell, Carcinoma                    | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +  +  +     +                                             |  50        |
      Mesothelioma Malignant               |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +           +  +  +     +                                             |  50        |
      Adenoma                              |                      X                                                   |          8 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Bilateral, Carcinoma                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +           +  +  +     +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                   X                                                      |          3 |
      Interstitial Cell, Adenoma           |                                                                          |          4 |
      Interstitial Cell, Adenoma, Multiple | X  X              X  X                                                   |         38 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +  +     +                                             |  49        |
      Leukemia Mononuclear                 |    X           X           X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +           +  +  +     +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                            X                                             |          1 |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Thyroid Gland                   | X                                                                        |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |    X                       X                                             |          4 |
      Mediastinal, Leukemia Mononuclear    |                            X                                             |          4 |
      Pancreatic, Leukemia Mononuclear     |                            X                                             |          4 |
      Renal, Leukemia Mononuclear          |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |    X                       X                                             |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +  +  +     +                                             |  49        |
      Leukemia Mononuclear                 |    X           X  X        X                                             |         23 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                            X                                             |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +           +  +  +     +                                             |  48        |
      Fibroadenoma                         |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +  +  +     +                                             |  49        |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Benign                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +                 +  +                                                   |  26        |
      Carcinoma, Metastatic, Thyroid Gland | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +  +     +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |          1 |
      Carcinoma, Metastatic, Thyroid Gland | X                                                                        |          1 |
      Leukemia Mononuclear                 |    X           X           X                                             |         19 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +  +  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +  +     +                                             |  50        |
      Carcinoma, Metastatic, Thyroid Gland | X                                                                        |          1 |
      Leukemia Mononuclear                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      External Ear, Squamous Cell Carcinoma|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +           +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |    X           X  X        X                                             |         23 |
      Mesothelioma Malignant               |                   X                                                      |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +              +     +        +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +              A              +              +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X  X                 X        X     X           X      |             
      Neoplastic Nodule                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +              +  +  +        +              +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Tissue NOS      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +     +              +     +        +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +     +              +     +        +  +           +        +   |             
      Sarcoma, Metastatic, Tissue NOS      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +     +              +     +        +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +     +     +  +     +              +              +        +   |             
      Leukemia Mononuclear                 |                      X                                                   |             
      Sarcoma, Metastatic, Skin            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Malignant           |                                                 X              X         |             
      Pheochromocytoma Malignant, Multiple |                                                                          |             
      Pheochromocytoma Benign              |       X              X        X        X        X     X  X               |             
      Pheochromocytoma Benign, Multiple    |    X        X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +              +  +  +        +              +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +              +              M              +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +        +  +  +  +  +   |             
      Pars Distalis, Adenoma               |                X  X     X     X     X        X                           |             
      Pars Distalis, Leukemia Mononuclear  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  +              +              +           +  +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |             X                                                            |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
      Sarcoma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +              +              +              +        +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +  +     +        +     +              +  +  +  +   |             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            |                      X                 X                                 |             
      Bilateral, Carcinoma                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Prostate                                |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +           +  +     +     +  +  +  +     +  +        +  +     +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Mesothelioma Benign                  |                                                                          |             
      Interstitial Cell, Adenoma           |                   X           X                       X                  |             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X        X  X        X  X  X        X        X        X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +              +              +              +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +  +     +  +     +     +        +  +  +        +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                      X                                                   |             
      Mediastinal, Leukemia Mononuclear    |                                        X              X                  |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +              +              +              +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X  X                 X        X     X  X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +              +              +              +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +     +     +              +              +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    |       +        +  +  +        +              +              +        +   |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Sebaceous Gland, Adenoma             |       X                                                                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Tissue NOS                       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                             +              +        +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +     +  +           +           +  +     +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                      X                                                   |             
      Leukemia Mononuclear                 |                X     X                                                   |             
      Sarcoma, Metastatic, Skin            |                                                                      X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Zymbal's Gland                  |                                                                          |             
      Mediastinum, Hemangiosarcoma         |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +              +              +              +        +   |             
      Sarcoma, Metastatic, Skin            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +     +  +  +        +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +              +              +              +        +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X  X                 X        X     X  X        X      |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +           +  +     +  +        +              +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +  +     +  +        +              +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +  +           +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X  X     X     X        X  X     X  X                 X  X     X  X  X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +           +  +     +  +        +              +                    +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +        +  +     +  +        +              +  +                 +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +  +     +  +        +              +  +                 +|             
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +  +     +  +        +              +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +  +     +  +        +              +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X  X                    X  X                          X        X     X|             
      Pheochromocytoma Malignant           |                                                                   X      |             
      Pheochromocytoma Malignant, Multiple |                                           X                              |             
      Pheochromocytoma Benign              |                                                       X     X            |             
      Pheochromocytoma Benign, Multiple    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +  +     M  +        +     +        +                    +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |                X                                      X                  |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +  +     +  +        +              +     +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +  +        +        +              +                    +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +  +     +  +        +              +                    +|             
      Adenoma                              |                   X     X                                                |             
      Carcinoma                            |                                                                          |             
      Bilateral, Carcinoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     A  +     +  +  +     +  +  +        +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Mesothelioma Benign                  |                   X                                                      |             
      Interstitial Cell, Adenoma           |       X        X                    X                                    |             
      Interstitial Cell, Adenoma, Multiple | X        X  X                 X        X  X        X  X  X  X        X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +  +     +  +        +              +                    +|             
      Leukemia Mononuclear                 |    X                                                                    X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +  +     +  +  +     +     +        +  +     +           +|             
      Leukemia Mononuclear                 |                                                                          |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |    X                                                                     |             
      Mandibular, Leukemia Mononuclear     |    X                                                                     |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X                                                        X            |             
      Pancreatic, Leukemia Mononuclear     |    X                                                        X           X|             
      Renal, Leukemia Mononuclear          |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +     +  +        +     +        +  +                 +|             
      Leukemia Mononuclear                 |                            X                                            X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +     +  +           +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Leukemia Mononuclear                 |    X  X     X     X        X  X     X  X                 X  X     X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +  M     +  +        +              +                    M|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +  +     +  +        +              +                    +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +  +     +  +  +     +     +        +                    +|             
      Keratoacanthoma                      |                                           X                              |             
      Squamous Cell Carcinoma              |                               X                                          |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Tissue NOS                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +  +     +  +        +              +                    +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +  +     +  +  +     +              +     +  +     +     +|             
      Alveolar/Bronchiolar Adenoma         |             X                                                            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |    X  X                    X        X                       X     X     X|             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Zymbal's Gland                  |                                                    X                     |             
      Mediastinum, Hemangiosarcoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +  +     +  +        +              +                    +|             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
      Squamous Cell Carcinoma              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X                                                     X           X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +  +     +  +        +              +                    +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Leukemia Mononuclear                 |    X  X     X     X        X  X     X  X                 X  X     X  X  X|             
      Mesothelioma Benign                  |                   X                                                      |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +                                                            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +                                                            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +                                                            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +                                                            |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 | X  X  X     X        X  X  X                                             |         27 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                                                            |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +        +                                                   |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +        +                                                   |  21        |
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +        +                                                   |  21        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +                                                            |  20        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X              X  X                                                |         11 |
      Pheochromocytoma Malignant           |                                                                          |          3 |
      Pheochromocytoma Malignant, Multiple |                                                                          |          1 |
      Pheochromocytoma Benign              | X           X     X  X     X                                             |         14 |
      Pheochromocytoma Benign, Multiple    |                         X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +                                                            |  16        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +                                             |  49        |
      Pars Distalis, Adenoma               |                                                                          |          8 |
      Pars Distalis, Leukemia Mononuclear  |                      X  X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +                                                            |  18        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +                                                            |  13        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +           +                                                            |  20        |
      Adenoma                              | X                                                                        |          4 |
      Carcinoma                            |                                                                          |          2 |
      Bilateral, Carcinoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +     A  +     +                                             |  37        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Mesothelioma Benign                  |                                                                          |          1 |
      Interstitial Cell, Adenoma           |    X        X        X                                                   |          9 |
      Interstitial Cell, Adenoma, Multiple | X     X  X        X     X  X                                             |         31 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                                                            |  14        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +           +  +                                             |  33        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Axillary, Leukemia Mononuclear       |                         X                                                |          1 |
      Iliac, Leukemia Mononuclear          |                         X                                                |          2 |
      Mandibular, Leukemia Mononuclear     |                         X                                                |          2 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |             X           X  X                                             |          7 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          4 |
      Renal, Leukemia Mononuclear          |                         X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +                                                            |  18        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +                                             |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X     X        X  X  X                                             |         29 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +           +                                                |  14        |
      Leukemia Mononuclear                 |       X                 X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +                                                            |  18        |
      Adenocarcinoma                       |       X                                                                  |          1 |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +     +     +                                                |  21        |
      Keratoacanthoma                      |                   X                                                      |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                   X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |            |
          Tissue NOS                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                                                            |  13        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +           +  +                                             |  30        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Preputial     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                    X  X                                             |         12 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Zymbal's Gland                  |                                                                          |          1 |
      Mediastinum, Hemangiosarcoma         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                                                            |  14        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +        +     +                                             |  45        |
      Leukemia Mononuclear                 |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +                                                            |  14        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X     X        X  X  X                                             |         29 |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X  X  X     X           X        X              X  X  X  X|             
      Mesothelioma Malignant               |                                                             X            |             
      Neoplastic Nodule                    |                                                          X               |             
      Neoplastic Nodule, Multiple          |                                                                X         |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                         +            |             
      Fibrous Histiocytoma                 |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                       X                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                                                                          |             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                             X                                 |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +  +         |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                             X                             X   |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                       X        X                        |             
      Pheochromocytoma Malignant           |       X                                                                  |             
      Pheochromocytoma Malignant, Multiple |                                                                      X   |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              | X           X        X  X  X                       X  X                  |             
      Pheochromocytoma Benign, Multiple    |                                                                X        X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                    X     X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +     +     M        +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X           X        X                             X                     |             
      Pars Distalis, Leukemia Mononuclear  |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      C-Cell, Carcinoma                    |                X     X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
      Carcinoma                            |                                                                X         |             
      Fibrosarcoma                         |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Bilateral, Carcinoma                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |                      X                                                   |             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X  X  X     X  X     X     X        X     X  X  X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                               X     X   |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Inguinal, Renal, Iliac, Bronchial,   |                                                                          |             
           Mediastinal, Sarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                X                                               X         |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X        X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X  X  X     X           X        X              X  X  X  X|             
      Mesothelioma Malignant               |                                                             X            |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  M  M  +  +  +  +|             
      Leukemia Mononuclear                 |                X                       X        X                 X  X   |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                             X            |             
      Trichoepithelioma                    |                                                       X                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                                       |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Mesothelioma Malignant    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |          X                                                        X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +        +  +  +  +  +                             +  +  +        +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                   X                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                          X               |             
      Leukemia Mononuclear                 |          X  X  X     X     X           X        X              X  X  X   |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                         +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
      Adenoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                       X        X                 X      |             
      Mesothelioma Malignant               |                                                             X            |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X  X  X     X           X        X              X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X  X        X              X        X           X           X  X  X     X|             
      Mesothelioma Malignant               |                                                                          |             
      Neoplastic Nodule                    |          X                             X                          X      |             
      Neoplastic Nodule, Multiple          |                                                                          |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fibrous Histiocytoma                 |                               X                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X           X                                   X              X        X|             
      Sarcoma, Metastatic, Skin            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X  X                                            X              X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                    X              X        X|             
      Pheochromocytoma Malignant           |          X                                            X                  |             
      Pheochromocytoma Malignant, Multiple |    X                                X                             X      |             
      Pheochromocytoma Complex             |                                                                         X|             
      Pheochromocytoma Benign              |       X  X        X                                         X           X|             
      Pheochromocytoma Benign, Multiple    |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +     +     +  +  +     +  +     +  +     +  M  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Pars Distalis, Adenoma               | X                 X           X                                   X      |             
      Pars Distalis, Leukemia Mononuclear  | X           X                                   X              X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      C-Cell, Carcinoma                    |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +     +  +  +     +  +     M  +     +  +  +  +  +     +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 |             X                                                  X         |             
      Squamous Cell Papilloma              |       X                                                                  |             
      Bilateral, Carcinoma                 |                               X                                   X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  M  +     +|             
      Leukemia Mononuclear                 | X           X                                                            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |    X                                                                    X|             
      Interstitial Cell, Adenoma, Multiple | X     X  X  X     X     X  X  X     X  X        X     X  X  X     X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                  X         |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Axillary, Leukemia Mononuclear       | X           X                                                            |             
      Iliac, Leukemia Mononuclear          | X           X                                                            |             
      Inguinal, Leukemia Mononuclear       |                                                                X         |             
      Inguinal, Renal, Iliac, Bronchial,   |                                                                          |             
           Mediastinal, Sarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                              X                           |             
      Lumbar, Leukemia Mononuclear         | X                                                                        |             
      Mandibular, Leukemia Mononuclear     | X  X        X                       X                          X         |             
      Mediastinal, Leukemia Mononuclear    |             X                       X                          X         |             
      Pancreatic, Leukemia Mononuclear     |                                                                         X|             
      Renal, Leukemia Mononuclear          | X           X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                   X           X              X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X  X        X           X  X        X           X           X  X  X     X|             
      Mesothelioma Malignant               |                                                                          |             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X  X        X                                   X              X         |             
      Sarcoma, Metastatic, Skin            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Fibroadenoma                         |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Keratoacanthoma                      |                                                 X                        |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                                          X               |             
      Subcutaneous Tissue, Fibroma         |                               X                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                             X            |             
      Subcutaneous Tissue, Sarcoma         |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Mesothelioma Malignant    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Astrocytoma Malignant                |                                                       X                  |             
      Leukemia Mononuclear                 | X                                               X                       X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +        +     +           +  +                    +     +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia Mononuclear                 | X  X        X              X        X           X              X  X     X|             
      Neuroblastoma Malignant, Metastatic, |                                                                          |             
           Adrenal Gland                   |                                     X                                    |             
      Sarcoma, Metastatic, Skin            |                                              X                           |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X  X        X                                   X              X         |             
      Mesothelioma Malignant               |                                                                          |             
      Renal Tubule, Adenoma                |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X  X        X           X  X        X           X           X  X  X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X     X  X     X                                                   |         27 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Neoplastic Nodule                    |                                                                          |          4 |
      Neoplastic Nodule, Multiple          |                                                                          |          1 |
      Neuroblastoma Malignant, Metastatic, |                                                                          |            |
           Adrenal Gland                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                                                                     |   5        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Mesothelioma Malignant               | X  X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | M  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Mesothelioma Malignant               | X                                                                        |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
      Mesothelioma Malignant               | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   3        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  66                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |             X                                                            |          8 |
      Pheochromocytoma Malignant           |             X                                                            |          4 |
      Pheochromocytoma Malignant, Multiple |                                                                          |          4 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |    X                    X                                                |         14 |
      Pheochromocytoma Benign, Multiple    |       X                    X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                X           X                                             |          2 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Adenoma               |             X  X                                                         |         10 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Carcinoma                    |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               | X  X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |    X                    X                                                |          4 |
      Carcinoma                            |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Bilateral, Carcinoma                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  M                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
      Mesothelioma Malignant               | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               | X  X                                                                     |          3 |
      Interstitial Cell, Adenoma           |                                                                          |          3 |
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X  X  X     X  X                                             |         43 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          6 |
      Neuroblastoma Malignant, Metastatic, |                                                                          |            |
           Adrenal Gland                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Inguinal, Renal, Iliac, Bronchial,   |                                                                          |            |
           Mediastinal, Sarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                                                                          |          7 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          3 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X     X  X     X                                                   |         28 |
      Mesothelioma Malignant               | X  X                                                                     |          3 |
      Neuroblastoma Malignant, Metastatic, |                                                                          |            |
           Adrenal Gland                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +                                             |  46        |
      Leukemia Mononuclear                 |                      X                                                   |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibroadenoma                         | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Keratoacanthoma                      |                            X                                             |          2 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Trichoepithelioma                    |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |          2 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
      Diaphragm, Mesothelioma Malignant    |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |             X                                                            |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +     +  +  +  +     +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X  X     X                                                   |         23 |
      Neuroblastoma Malignant, Metastatic, |                                                                          |            |
           Adrenal Gland                   |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05706-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:53:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |         11 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
      Mesothelioma Malignant               | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X     X  X     X                                                   |         28 |
      Mesothelioma Malignant               | X  X                                                                     |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------