Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4629

TDMS Study 05706-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


NTP Experiment-Test: 05706-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 23:48:57




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           14           16                                                  
    Dead                                               5            3            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           32           33                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (8)          (50)                                                
   Intestine Large, Colon                             (49)         (8)          (50)                                                
   Intestine Large, Rectum                            (49)         (8)          (50)                                                
   Intestine Small, Ileum                             (49)         (8)          (50)                                                
   Intestine Small, Jejunum                           (49)         (8)          (50)                                                
   Liver                                              (50)         (42)         (50)                                                
      Neoplastic Nodule                                3 (6%)                    1 (2%)                                             
   Mesentery                                          (2)          (2)          (3)                                                 
   Pancreas                                           (49)         (8)          (50)                                                
   Salivary Glands                                    (49)         (8)          (50)                                                
   Stomach, Forestomach                               (50)         (10)         (50)                                                
   Stomach, Glandular                                 (49)         (10)         (50)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (8)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)                                                
      Adenoma                                                                    2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Pheochromocytoma Malignant                                    2 (4%)                                                          
      Pheochromocytoma Benign                          2 (4%)       4 (8%)       5 (10%)                                            
   Islets, Pancreatic                                 (49)         (8)          (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (37)         (49)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          15 (30%)     20 (54%)     13 (27%)                                            
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
   Thyroid Gland                                      (49)         (10)         (49)                                                
      C-Cell, Adenoma                                  2 (4%)                    3 (6%)                                             
      C-Cell, Carcinoma                                2 (4%)       2 (20%)      5 (10%)                                            
      Follicular Cell, Adenoma                                      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (13)         (46)                                                
      Adenoma                                          3 (6%)       5 (38%)      4 (9%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (8)          (50)                                                
      Granulosa Cell Tumor Benign                                                2 (4%)                                             
   Uterus                                             (50)         (22)         (50)                                                
      Leiomyosarcoma                                                1 (5%)                                                          
      Cervix, Carcinoma                                1 (2%)                                                                       
      Cervix, Leiomyosarcoma                           1 (2%)                                                                       
      Cervix, Squamous Cell Carcinoma                               1 (5%)                                                          
      Endometrium, Polyp Stromal                       9 (18%)      8 (36%)     11 (22%)                                            
      Endometrium, Sarcoma Stromal                                  1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (8)          (50)                                                
   Lymph Node                                         (50)         (27)         (49)                                                
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (8)          (49)                                                
      Axillary, Mediastinal, Adenocarcinoma,                                                                                        
          Metastatic, Skin                             1 (2%)                                                                       
   Spleen                                             (49)         (22)         (50)                                                
   Thymus                                             (48)         (8)          (49)                                                
      Thymoma Benign                                   1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (47)         (50)                                                
      Adenocarcinoma                                   1 (2%)       2 (4%)       3 (6%)                                             
      Adenoma                                          2 (4%)       1 (2%)       2 (4%)                                             
      Fibroadenoma                                     9 (18%)     17 (36%)     19 (38%)                                            
      Fibroadenoma, Multiple                           2 (4%)       4 (9%)       2 (4%)                                             
   Skin                                               (50)         (8)          (50)                                                
      Sebaceous Gland, Adenocarcinoma                  1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (8)          (50)                                                
      Astrocytoma Benign                                            1 (13%)                                                         
      Glioma Benign                                    1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (33)                      (38)                                                
   Lung                                               (50)         (29)         (50)                                                
      Adenocarcinoma, Metastatic, Skin                 1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                                  1 (3%)       1 (2%)                                             
   Nose                                               (49)         (8)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (5)          (2)                                                 
   Zymbal's Gland                                     (2)          (1)                                                              
      Squamous Cell Carcinoma                          2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (9)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            16 (32%)     14 (28%)     15 (30%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      12500PPM     25000PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          44          50                                                   
     Total Primary Neoplasms                           77          86          97                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          36          44                                                   
     Total Benign Neoplasms                            52          62          72                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          21          22                                                   
     Total Malignant Neoplasms                         25          24          25                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          3                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          21           24           20                                                  
    Dead                                               7            6            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           20           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (14)         (49)                                                
   Intestine Large, Rectum                            (47)         (14)         (48)                                                
   Intestine Small, Duodenum                          (48)         (12)         (49)                                                
   Intestine Small, Ileum                             (48)         (12)         (48)                                                
      Adenoma, Papillary                               1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (11)         (48)                                                
   Liver                                              (50)         (49)         (50)                                                
      Neoplastic Nodule                                1 (2%)       1 (2%)       4 (8%)                                             
      Neoplastic Nodule, Multiple                                                1 (2%)                                             
      Neuroblastoma Malignant, Metastatic, Adrenal                                                                                  
          Gland                                                                  1 (2%)                                             
   Mesentery                                          (5)          (2)          (5)                                                 
      Fibrous Histiocytoma                                                       1 (20%)                                            
   Pancreas                                           (49)         (16)         (49)                                                
      Sarcoma, Metastatic, Tissue NOS                               1 (6%)                                                          
   Salivary Glands                                    (50)         (14)         (50)                                                
   Stomach, Forestomach                               (49)         (21)         (49)                                                
      Sarcoma, Metastatic, Tissue NOS                               1 (5%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (48)         (21)         (50)                                                
   Tongue                                                                       (3)                                                 
      Squamous Cell Papilloma                                                    1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (20)         (50)                                                
      Sarcoma, Metastatic, Skin                                     1 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
   Adrenal Gland, Medulla                             (48)         (50)         (50)                                                
      Pheochromocytoma Malignant                       2 (4%)       3 (6%)       4 (8%)                                             
      Pheochromocytoma Malignant, Multiple                          1 (2%)       4 (8%)                                             
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                         12 (25%)     14 (28%)     14 (28%)                                            
      Pheochromocytoma Benign, Multiple                4 (8%)       4 (8%)       5 (10%)                                            
   Islets, Pancreatic                                 (49)         (16)         (49)                                                
      Adenoma                                                                    2 (4%)                                             
      Carcinoma                                        1 (2%)                    2 (4%)                                             
   Parathyroid Gland                                  (49)         (15)         (45)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Adenoma                          16 (32%)      8 (16%)     10 (20%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
   Thyroid Gland                                      (49)         (18)         (50)                                                
      C-Cell, Adenoma                                  2 (4%)       1 (6%)                                                          
      C-Cell, Carcinoma                                2 (4%)       1 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (13)         (50)                                                
   Preputial Gland                                    (50)         (20)         (49)                                                
      Adenoma                                          8 (16%)      4 (20%)      4 (8%)                                             
      Carcinoma                                        1 (2%)       2 (10%)      1 (2%)                                             
      Fibrosarcoma                                                               1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Bilateral, Carcinoma                             2 (4%)       1 (5%)       3 (6%)                                             
   Prostate                                           (50)         (14)         (49)                                                
   Seminal Vesicle                                    (48)         (37)         (47)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                       4 (8%)       9 (18%)      3 (6%)                                             
      Interstitial Cell, Adenoma, Multiple            38 (76%)     31 (62%)     43 (86%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (14)         (50)                                                
      Neuroblastoma Malignant, Metastatic, Adrenal                                                                                  
          Gland                                                                  1 (2%)                                             
   Lymph Node                                         (50)         (33)         (50)                                                
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (2%)                                                                       
      Inguinal, Renal, Iliac, Bronchial,                                                                                            
          Mediastinal, Sarcoma, Metastatic, Skin                                 1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (3%)                                                          
   Lymph Node, Mesenteric                             (50)         (18)         (50)                                                
   Spleen                                             (49)         (49)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Neuroblastoma Malignant, Metastatic, Adrenal                                                                                  
          Gland                                                                  1 (2%)                                             
   Thymus                                             (50)         (14)         (46)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (18)         (50)                                                
      Adenocarcinoma                                                1 (6%)                                                          
      Fibroadenoma                                     3 (6%)       2 (11%)      4 (8%)                                             
   Skin                                               (49)         (21)         (50)                                                
      Keratoacanthoma                                  2 (4%)       2 (10%)      2 (4%)                                             
      Squamous Cell Carcinoma                          1 (2%)       1 (5%)                                                          
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Trichoepithelioma                                                          2 (4%)                                             
      Sebaceous Gland, Adenoma                                      1 (5%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (5%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    2 (4%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  2 (10%)      1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Diaphragm, Sarcoma, Metastatic, Tissue NOS                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (26)                      (27)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (4%)                                                                       
   Lung                                               (50)         (30)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (3%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (3%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Carcinoma, Metastatic, Preputial Gland                        1 (3%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Neuroblastoma Malignant, Metastatic, Adrenal                                                                                  
          Gland                                                                  1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (3%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Zymbal's Gland                                            1 (3%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma                                1 (2%)                                             
      Mediastinum, Hemangiosarcoma                                  1 (3%)                                                          
   Nose                                               (49)         (14)         (50)                                                
   Trachea                                            (50)         (14)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                     1 (7%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      External Ear, Squamous Cell Carcinoma            1 (100%)                                                                     
   Zymbal's Gland                                                  (1)          (1)                                                 
      Adenoma                                                                    1 (100%)                                           
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (45)         (50)                                                
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (14)         (49)                                                
                                                             Page  10                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            23 (46%)     29 (58%)     28 (56%)                                            
      Mesothelioma Benign                                           1 (2%)                                                          
      Mesothelioma Malignant                           3 (6%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05706-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 23:48:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      12500PPM     25000PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50                                                   
     Total Primary Neoplasms                          136         127         161                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          44          48                                                   
     Total Benign Neoplasms                            97          80         104                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          38          42                                                   
     Total Malignant Neoplasms                         39          47          57                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           2                                                   
     Total Metastatic Neoplasm                          4           9           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------