Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4986

TDMS Study 05706-02 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/18/94   
EXP: 05706         4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID     TIME: 23:59:13   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C60162   
CONT:                                                          CAS: 81-11-8     
PATHOLOGIST: W. HALL                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/18/94  
EXP: 05706         4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID     TIME: 23:59:13  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C60162  
CONT:                                                          CAS: 81-11-8    
PATHOLOGIST: W. HALL                         S. EUSTIS                         

                      4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 28     CENSORED DEATHS 10   TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      67    379   443   446   540   561   562   571   579   580                 |
 |      606   620   624   624   628   630   640   641   648   662                 |
 |      687   692   692   696   704   704   708   713                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 12500PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 30     CENSORED DEATHS 10   TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      134   327   510   521   521   571   580   583   595   609                 |
 |      615   618   621   623   644   653   658   663   663   663                 |
 |      676   683   683   687   697   697   719   725   725   725                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25000PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 26     CENSORED DEATHS 10   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      491   508   520   538   551   555   561   563   565   588                 |
 |      588   613   624   635   644   644   658   663   676   676                 |
 |      683   697   700   704   718   720                                         |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                      4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.3  98.3  98.3  98.3  96.7  93.3  91.3  81.2  60.9  44.6      |
 |           |                                                                    |
 |           |                                                                    |
 |12500PPM   |   100.0  98.3  98.3  96.7  96.7  96.7  90.6  82.6  60.4  40.3      |
 |           |                                                                    |
 |           |                                                                    |
 |25000PPM   |   100.0 100.0 100.0 100.0 100.0 100.0  92.0  78.0  64.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          12500PPM         25000PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       44.6%            40.3%            48.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.729N         P=0.945          P=0.785N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       594.5            613.0            618.6         |
 |NATURAL DEATHS (C)      |       (25.2)           (22.4)           (13.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       620.8            625.5            635.7         |
 |(STANDARD ERROR)        |       (17.1)           (16.3)           (13.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                      4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      99    528   559   578   578   603   638   644   653   664                 |
 |      664   682   684   686   686   687   700   713   713   728                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 12500PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      118   558   565   583   583   588   621   630   643   643                 |
 |      663   671   698   706   708   718   722                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25000PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      351   638   638   664   671   672   681   686   692   700                 |
 |      700   706   718   719   719   719   722                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                      4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.3  98.3  98.3  98.3  98.3  96.3  88.3  78.3  60.2      |
 |           |                                                                    |
 |           |                                                                    |
 |12500PPM   |   100.0  98.3  98.3  98.3  98.3  98.3  98.3  88.3  78.3  66.2      |
 |           |                                                                    |
 |           |                                                                    |
 |25000PPM   |   100.0 100.0 100.0  98.3  98.3  98.3  98.3  98.3  92.3  66.2      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          12500PPM         25000PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       60.2%            66.2%            66.2%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.440N         P=0.701N         P=0.480N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       624.4            612.8            670.4         |
 |NATURAL DEATHS (C)      |       (30.3)           (33.7)           (21.0)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       648.6            650.6            666.9         |
 |(STANDARD ERROR)        |       (16.2)           (16.1)           (14.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        12500PPM         = 2
                                                        25000PPM         = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1          1          2                                                       3
      |            1          2                             2        1        1       3 2
      |                                                                                 2  2 3
      |                                                                       1              313 1
P  90 +                                                                                    2   33 2
E     |                                                                                         31122
R     |                                                                                           112 2
C     |                                                                                          3  3 2 2
E  80 +                                                                                            1    121
N     |                                                                                             3    211
T     |                                                                                                  3 33
      |                                                                                                   2 32
S  70 +                                                                                                    1 1 2
U     |                                                                                                      3 2 2
R     |                                                                                                      113 3 3
V     |                                                                                                       1  1
I  60 +                                                                                                          1 231
V     |                                                                                                            22 3
A     |                                                                                                             2113
L     |                                                                                                              211 3
   50 +
      |                                                                                                               21122 3
      |                                                                                                                 1   1
      |
   40 +                                                                                                                   2 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 30 obs hidden.

                                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        12500PPM         = 2
                                                        25000PPM         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                1 2                                    3
      |                  1 2                                    3                           1   2            3
      |
      |                                                                                     1   12
   95 +
      |                                                                                         12 12        3   3
      |                                                                                                          33
      |
P  90 +                                                                                            1    1
E     |                                                                                             2   1 2  1    3 3
R     |
C     |                                                                                                   22
E  85 +
N     |                                                                                                    2 1 1    33
T     |                                                                                                        1 1   33
      |
S  80 +                                                                                                      2   2
U     |                                                                                                          12 1 33
R     |
V     |                                                                                                           2   23 3
I  75 +
V     |                                                                                                               22
A     |                                                                                                                22
L     |
   70 +                                                                                                             11  22
      |                                                                                                              11  22
      |
      |                                                                                                               1 1 2 2
   65 +
      |
      |                                                                                                                 1 1
      |
   60 +                                                                                                                   1 1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.