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TDMS Study 93021-05 Pathology Tables

NTP Experiment-Test: 93021-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97
Route: SKIN APPLICATION                                                                                           Time: 10:20:27

                                                       150 DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  538-75-0

       Lock Date:  03/26/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93021-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:27  
____________________________________________________________________________________________________________________________________

         TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0            .75          1.5          3            6            12              
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            2                         2            2                        
    Natural Death                                      1            1                         1                         1           
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            7           10            6            8            9           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (9)          (3)                       (3)          (2)          (7)          
      Inflammation                                                  1 (33%)                                             1 (14%)     
   Intestine Large, Rectum                            (9)          (3)                       (4)          (2)          (9)          
      Anus, Inflammation                                                                                   1 (50%)                  
   Liver                                              (10)         (6)          (6)          (7)          (10)         (10)         
      Fibrosis                                                      1 (17%)                                             1 (10%)     
      Hematopoietic Cell Proliferation                 1 (10%)      1 (17%)                                2 (20%)      1 (10%)     
      Inflammation, Chronic Active, Focal                           3 (50%)      3 (50%)      4 (57%)      6 (60%)      2 (20%)     
      Inflammation, Focal                              3 (30%)                                                          5 (50%)     
      Necrosis                                                      1 (17%)      1 (17%)      2 (29%)      1 (10%)                  
      Necrosis, Focal                                  1 (10%)                                                          1 (10%)     
   Stomach, Forestomach                               (10)         (4)          (2)          (5)          (4)          (10)         
      Inflammation                                                  1 (25%)                                                         
   Stomach, Glandular                                 (10)         (3)                       (4)          (2)          (10)         
      Inflammation                                     1 (10%)                                                          1 (10%)     
      Serosa, Fibrosis                                                                                                  1 (10%)     
   Tooth                                              (4)          (5)          (6)          (4)          (5)          (5)          
      Inflammation, Chronic Active                                                                                      1 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (3)                       (4)          (2)          (10)         
      Inflammation, Acute                                                                                               1 (10%)     
      Mineralization, Focal                                                                                             1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)         (2)                       (3)          (1)          (8)          
      Pars Distalis, Necrosis, Focal                                                                       1 (100%)                 
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 93021-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:27  
____________________________________________________________________________________________________________________________________

         TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0            .75          1.5          3            6            12              
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (8)          (1)                       (4)          (1)          (9)          
      Inflammation                                                                                                      1 (11%)     
   Uterus                                             (10)         (3)                       (4)          (2)          (10)         
      Cyst                                             1 (10%)                                                          1 (10%)     
      Bilateral, Cyst                                                                                                   1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (3)                       (4)          (2)          (10)         
      Hyperplasia                                      3 (30%)                                2 (50%)      1 (50%)      2 (20%)     
      Myeloid Cell, Hyperplasia                                     1 (33%)                                                         
   Lymph Node                                                      (1)                                    (1)                       
      Bronchial, Infiltration Cellular, Plasma Cell                 1 (100%)                                                        
   Lymph Node, Mandibular                             (10)         (3)          (1)          (4)          (3)          (10)         
      Hematopoietic Cell Proliferation                              1 (33%)                                                         
      Hemorrhage                                                                              1 (25%)                               
      Infiltration Cellular, Plasma Cell                                         1 (100%)                               1 (10%)     
      Infiltration Cellular, Histiocyte                2 (20%)                                                          1 (10%)     
   Lymph Node, Mesenteric                             (9)          (3)                       (4)          (2)          (9)          
      Hematopoietic Cell Proliferation                              1 (33%)                                                         
      Infiltration Cellular, Histiocyte                1 (11%)                                                                      
      Necrosis, Focal                                  1 (11%)                                1 (25%)                               
   Spleen                                             (10)         (5)          (5)          (4)          (4)          (10)         
      Fibrosis                                                                                                          1 (10%)     
      Hematopoietic Cell Proliferation                 8 (80%)      4 (80%)      4 (80%)      3 (75%)      3 (75%)      9 (90%)     
      Lymphoid Follicle, Depletion Cellular                                                                             1 (10%)     
   Thymus                                             (9)          (3)                       (3)          (2)          (10)         
      Atrophy                                          1 (11%)      2 (67%)                   1 (33%)      2 (100%)     1 (10%)     
      Hemorrhage                                                                                                        1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage                                                                              1 (10%)                               
      Hyperplasia                                                                                                       1 (10%)     
      Inflammation, Chronic Active                                               1 (10%)                                            
      Dermis, Inflammation                                                                                 1 (10%)                  
      Dermis, Inflammation, Chronic Active                                                    1 (10%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 93021-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:27  
____________________________________________________________________________________________________________________________________

         TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0            .75          1.5          3            6            12              
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                                           3 (30%)      5 (50%)      8 (80%)                  
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                                         6 (60%)      7 (70%)      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (10)         (3)                       (4)          (2)          (10)         
      Synovial Tissue, Inflammation                    1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)         (3)                       (4)          (2)          (10)         
      Hemorrhage, Acute                                                                       1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                                                                              (1)          
      Inflammation                                                                                                      1 (100%)    
   Lung                                               (10)         (3)                       (4)          (2)          (10)         
      Hemorrhage, Acute                                                                       1 (25%)                               
      Inflammation, Chronic Active                                                                                      4 (40%)     
   Nose                                               (10)         (3)                       (4)          (5)          (10)         
      Inflammation                                                                                         3 (60%)      1 (10%)     
      Respiratory Epithelium, Inflammation                                                                              1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (3)                       (4)          (2)          (10)         
      Inflammation, Chronic Active                                  1 (33%)                                                         
      Bilateral, Inflammation                                                                                           1 (10%)     
      Cortex, Cyst                                     1 (10%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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