TDMS Study 93021-05 Pathology Tables
NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
150 DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 538-75-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
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TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 2 2 2 2
Natural Death 1 1 1 1
Accidently Killed 1
Survivors
Terminal Sacrifice 7 7 10 6 8 9
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Gallbladder (9) (3) (3) (2) (7)
Inflammation 1 (33%) 1 (14%)
Intestine Large, Rectum (9) (3) (4) (2) (9)
Anus, Inflammation 1 (50%)
Liver (10) (6) (6) (7) (10) (10)
Fibrosis 1 (17%) 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (17%) 2 (20%) 1 (10%)
Inflammation, Chronic Active, Focal 3 (50%) 3 (50%) 4 (57%) 6 (60%) 2 (20%)
Inflammation, Focal 3 (30%) 5 (50%)
Necrosis 1 (17%) 1 (17%) 2 (29%) 1 (10%)
Necrosis, Focal 1 (10%) 1 (10%)
Stomach, Forestomach (10) (4) (2) (5) (4) (10)
Inflammation 1 (25%)
Stomach, Glandular (10) (3) (4) (2) (10)
Inflammation 1 (10%) 1 (10%)
Serosa, Fibrosis 1 (10%)
Tooth (4) (5) (6) (4) (5) (5)
Inflammation, Chronic Active 1 (20%)
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CARDIOVASCULAR SYSTEM
Heart (10) (3) (4) (2) (10)
Inflammation, Acute 1 (10%)
Mineralization, Focal 1 (10%)
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ENDOCRINE SYSTEM
Pituitary Gland (10) (2) (3) (1) (8)
Pars Distalis, Necrosis, Focal 1 (100%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (8) (1) (4) (1) (9)
Inflammation 1 (11%)
Uterus (10) (3) (4) (2) (10)
Cyst 1 (10%) 1 (10%)
Bilateral, Cyst 1 (10%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (10) (3) (4) (2) (10)
Hyperplasia 3 (30%) 2 (50%) 1 (50%) 2 (20%)
Myeloid Cell, Hyperplasia 1 (33%)
Lymph Node (1) (1)
Bronchial, Infiltration Cellular, Plasma Cell 1 (100%)
Lymph Node, Mandibular (10) (3) (1) (4) (3) (10)
Hematopoietic Cell Proliferation 1 (33%)
Hemorrhage 1 (25%)
Infiltration Cellular, Plasma Cell 1 (100%) 1 (10%)
Infiltration Cellular, Histiocyte 2 (20%) 1 (10%)
Lymph Node, Mesenteric (9) (3) (4) (2) (9)
Hematopoietic Cell Proliferation 1 (33%)
Infiltration Cellular, Histiocyte 1 (11%)
Necrosis, Focal 1 (11%) 1 (25%)
Spleen (10) (5) (5) (4) (4) (10)
Fibrosis 1 (10%)
Hematopoietic Cell Proliferation 8 (80%) 4 (80%) 4 (80%) 3 (75%) 3 (75%) 9 (90%)
Lymphoid Follicle, Depletion Cellular 1 (10%)
Thymus (9) (3) (3) (2) (10)
Atrophy 1 (11%) 2 (67%) 1 (33%) 2 (100%) 1 (10%)
Hemorrhage 1 (10%)
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INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Hemorrhage 1 (10%)
Hyperplasia 1 (10%)
Inflammation, Chronic Active 1 (10%)
Dermis, Inflammation 1 (10%)
Dermis, Inflammation, Chronic Active 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 3 (30%) 5 (50%) 8 (80%)
Epidermis, Skin, Site of Application,
Hyperplasia 6 (60%) 7 (70%) 1 (10%)
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MUSCULOSKELETAL SYSTEM
Bone (10) (3) (4) (2) (10)
Synovial Tissue, Inflammation 1 (10%)
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NERVOUS SYSTEM
Brain (10) (3) (4) (2) (10)
Hemorrhage, Acute 1 (25%)
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RESPIRATORY SYSTEM
Larynx (1)
Inflammation 1 (100%)
Lung (10) (3) (4) (2) (10)
Hemorrhage, Acute 1 (25%)
Inflammation, Chronic Active 4 (40%)
Nose (10) (3) (4) (5) (10)
Inflammation 3 (60%) 1 (10%)
Respiratory Epithelium, Inflammation 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (3) (4) (2) (10)
Inflammation, Chronic Active 1 (33%)
Bilateral, Inflammation 1 (10%)
Cortex, Cyst 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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