Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5012

TDMS Study 55301-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/26/97

EXPERIMENT: 55301 TEST: 04                                                                                     TIME: 13:39:39
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B
PATHOLOGIST: F. VOELKER                      STEDHAM, MICHAEL                                                  CAS: 110-86-1
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/26/97     
EXPERIMENT: 55301 TEST: 04                                                                                     TIME: 13:39:39     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B     
PATHOLOGIST: F. VOELKER                      STEDHAM, MICHAEL                                                  CAS: 110-86-1      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                     PYRIDINE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Harderian Gland                        Carcinoma or Adenoma
Liver                                  Hepatoblastoma
                                       Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung                                   Alveolar/Bronchiolar Adenoma
All Organs                             Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Liver                                  Hepatoblastoma
                                       Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Ovary                                  Cystadenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
All Organs                             Hemangioma
                                       Hemangiosarcoma or Hemangioma
                                       Mesothelioma: Benign, Malignant, NOS
                                       Benign Tumors
                                       Malignant Tumors
===============================================================
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    0/49 (0%)    0/49 (0%)    1/49 (2%)   |1/49 (2%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.8%         0.0%         0.0%         2.4%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    0/27 (0%)    0/34 (0%)    1/34 (3%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     598          ---          ---          722 (T)     |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.244N     P=0.164N     P=0.129N     P=0.318N    |P=0.327N     P=0.513N     P=0.575N     P=0.520N     |
|POLY 3             |     P=0.234N     P=0.134N     P=0.126N     P=0.321N    |P=0.294N     P=0.506N     P=0.517N     P=0.516N     |
|POLY 1.5           |     P=0.239N     P=0.128N     P=0.124N     P=0.322N    |P=0.296N     P=0.506N     P=0.515N     P=0.512N     |
|POLY 6             |     P=0.229N     P=0.142N     P=0.127N     P=0.318N    |P=0.294N     P=0.507N     P=0.522N     P=0.519N     |
|LOGISTIC REGRESSION|     P=0.252N     P=0.123N     P=0.121N     P=0.314N    |P=0.327N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.247N     P=0.121N     P=0.121N     P=0.309N    |P=0.305N     P=0.495N     P=0.505N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.7%         0.0%         0.0%         2.3%        |0.0%         2.5%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/28 (0%)    0/35 (0%)    1/35 (3%)   |0/32 (0%)    1/30 (3%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     633          ---          ---          722 (T)     |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.242N     P=0.159N     P=0.129N     P=0.312N    |P=0.583N     P=0.487      (e)          (e)          |
|POLY 3             |     P=0.235N     P=0.133N     P=0.125N     P=0.320N    |P=0.582N     P=0.489      (e)          (e)          |
|POLY 1.5           |     P=0.239N     P=0.128N     P=0.124N     P=0.322N    |P=0.579N     P=0.490      (e)          (e)          |
|POLY 6             |     P=0.229N     P=0.141N     P=0.127N     P=0.316N    |P=0.586N     P=0.488      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.252N     P=0.126N     P=0.123N     P=0.316N    |(e)          P=0.487      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.247N     P=0.121N     P=0.121N     P=0.309N    |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         0.0%         0.0%        |2.3%         0.0%         0.0%         2.6%         |
|TERMINAL (d)       |     2/35 (6%)    0/28 (0%)    0/35 (0%)    0/35 (0%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          ---         |729 (T)      ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.112N     P=0.288N     P=0.238N     P=0.238N    |P=0.567      P=0.513N     P=0.575N     P=0.740      |
|POLY 3             |     P=0.108N     P=0.253N     P=0.244N     P=0.244N    |P=0.585      P=0.511N     P=0.515N     P=0.738      |
|POLY 1.5           |     P=0.109N     P=0.248N     P=0.243N     P=0.246N    |P=0.587      P=0.510N     P=0.511N     P=0.742      |
|POLY 6             |     P=0.106N     P=0.261N     P=0.244N     P=0.241N    |P=0.582      P=0.512N     P=0.521N     P=0.735      |
|LOGISTIC REGRESSION|     P=0.112N     (e)          (e)          (e)         |P=0.567      (e)          (e)          P=0.740      |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.595      P=0.500N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     11.1%        0.0%         0.0%         2.3%        |2.3%         2.5%         0.0%         2.6%         |
|TERMINAL (d)       |     3/35 (9%)    0/28 (0%)    0/35 (0%)    1/35 (3%)   |1/32 (3%)    1/30 (3%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     633          ---          ---          722 (T)     |729 (T)      729 (T)      ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.060N     P=0.056N     P=0.037N*    P=0.109N    |P=0.643N     P=0.748      P=0.575N     P=0.740      |
|POLY 3             |     P=0.052N     P=0.038N*    P=0.034N*    P=0.111N    |P=0.625N     P=0.749      P=0.515N     P=0.738      |
|POLY 1.5           |     P=0.055N     P=0.035N*    P=0.033N*    P=0.112N    |P=0.623N     P=0.750      P=0.511N     P=0.742      |
|POLY 6             |     P=0.050N     P=0.041N*    P=0.034N*    P=0.108N    |P=0.629N     P=0.748      P=0.521N     P=0.735      |
|LOGISTIC REGRESSION|     P=0.063N     P=0.040N*    P=0.035N*    P=0.110N    |P=0.643N     P=0.748      (e)          P=0.740      |
|COCH-ARM / FISHERS |     P=0.062N     P=0.028N*    P=0.028N*    P=0.102N    |P=0.616N     P=0.753N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    2/48 (4%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    0/47 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         4.7%         2.3%        |2.4%         4.9%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    0/34 (0%)    1/35 (3%)   |0/32 (0%)    1/30 (3%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          722 (T)      513          722 (T)     |554          696          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.376      P=0.455      P=0.235      P=0.500     |P=0.215N     P=0.481      P=0.509N     P=0.528N     |
|POLY 3             |     P=0.361      P=0.490      P=0.231      P=0.498     |P=0.208N     P=0.485      P=0.521N     P=0.523N     |
|POLY 1.5           |     P=0.354      P=0.495      P=0.230      P=0.496     |P=0.204N     P=0.488      P=0.517N     P=0.518N     |
|POLY 6             |     P=0.371      P=0.484      P=0.234      P=0.501     |P=0.213N     P=0.482      P=0.528N     P=0.527N     |
|LOGISTIC REGRESSION|     P=0.377      P=0.455      P=0.256      P=0.500     |P=0.193N     P=0.505      P=0.489N     P=0.469N     |
|COCH-ARM / FISHERS |     P=0.370      P=0.505      P=0.242      P=0.505     |P=0.191N     P=0.508      P=0.510N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.7%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     706          532          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.192N     P=0.458      P=0.505N     P=0.505N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.196N     P=0.482      P=0.511N     P=0.507N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.196N     P=0.487      P=0.509N     P=0.508N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.195N     P=0.474      P=0.512N     P=0.504N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.177N     P=0.526      P=0.510N     P=0.506N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.189N     P=0.500      P=0.505N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    18/50 (36%)  22/49 (45%)  15/50 (30%) |1/49 (2%)    2/50 (4%)    9/50 (18%)   16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     4.5%         41.2%        49.8%        34.4%       |2.4%         4.9%         21.6%        39.6%        |
|TERMINAL (d)       |     2/35 (6%)    11/28 (39%)  17/34 (50%)  13/35 (37%) |1/32 (3%)    1/30 (3%)    3/22 (14%)   12/29 (41%)  |
|FIRST INCIDENCE    |     722 (T)      549          514          624         |729 (T)      599          564          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.025 *    P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.482      P=0.005 **   P<0.001 **   |
|POLY 3             |     P=0.005 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.493      P=0.007 **   P<0.001 **   |
|POLY 1.5           |     P=0.005 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.492      P=0.007 **   P<0.001 **   |
|POLY 6             |     P=0.006 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.494      P=0.007 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.010 *    P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.496      P=0.009 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.012 *    P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.508      P=0.009 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     29/50 (58%)  40/50 (80%)  34/49 (69%)  39/50 (78%) |37/49 (76%)  39/50 (78%)  43/50 (86%)  34/50 (68%)  |
|POLY-3 ADJUSTED (b)|     63.2%        88.0%        75.7%        84.9%       |82.5%        87.9%        97.3%        79.1%        |
|TERMINAL (d)       |     24/35 (69%)  27/28 (96%)  27/34 (79%)  31/35 (89%) |27/32 (84%)  27/30 (90%)  22/22 (100%) 23/29 (79%)  |
|FIRST INCIDENCE    |     520          522          513          406         |554          419          509          430          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.179      P<0.001 **   P=0.165      P=0.035 *   |P=0.417      P=0.267      P=0.003 **   P=0.520      |
|POLY 3             |     P=0.031 *    P=0.003 **   P=0.134      P=0.011 *   |P=0.372N     P=0.336      P=0.015 *    P=0.442N     |
|POLY 1.5           |     P=0.025 *    P=0.005 **   P=0.133      P=0.009 **  |P=0.350N     P=0.326      P=0.022 *    P=0.428N     |
|POLY 6             |     P=0.044 *    P=0.002 **   P=0.143      P=0.016 *   |P=0.380N     P=0.344      P=0.011 *    P=0.448N     |
|LOGISTIC REGRESSION|     P=0.025 *    P=0.002 **   P=0.105      P=0.009 **  |P=0.450N     P=0.288      P=0.023 *    P=0.512N     |
|COCH-ARM / FISHERS |     P=0.060      P=0.015 *    P=0.166      P=0.026 *   |P=0.210N     P=0.478      P=0.142      P=0.272N     |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  35/50 (70%)  41/49 (84%)  40/50 (80%) |13/49 (27%)  23/50 (46%)  33/50 (66%)  41/50 (82%)  |
|POLY-3 ADJUSTED (b)|     32.3%        78.7%        89.9%        85.1%       |29.8%        55.0%        78.1%        97.1%        |
|TERMINAL (d)       |     9/35 (26%)   23/28 (82%)  32/34 (94%)  28/35 (80%) |8/32 (25%)   18/30 (60%)  20/22 (91%)  29/29 (100%) |
|FIRST INCIDENCE    |     574          522          513          406         |476          573          556          479          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/50 (34%)  42/50 (84%)  45/49 (92%)  42/50 (84%) |13/49 (27%)  23/50 (46%)  36/50 (72%)  43/50 (86%)  |
|POLY-3 ADJUSTED (b)|     36.7%        91.3%        96.8%        89.4%       |29.8%        55.0%        82.8%        99.0%        |
|TERMINAL (d)       |     11/35 (31%)  26/28 (93%)  34/34 (100%) 30/35 (86%) |8/32 (25%)   18/30 (60%)  20/22 (91%)  29/29 (100%) |
|FIRST INCIDENCE    |     574          522          513          406         |476          573          556          479          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     37/50 (74%)  45/50 (90%)  45/49 (92%)  47/50 (94%) |41/49 (84%)  42/50 (84%)  44/50 (88%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|     78.0%        96.5%        96.8%        100.0%      |89.9%        94.6%        98.4%        99.5%        |
|TERMINAL (d)       |     28/35 (80%)  28/28 (100%) 34/34 (100%) 35/35 (100%)|29/32 (91%)  29/30 (97%)  22/22 (100%) 29/29 (100%) |
|FIRST INCIDENCE    |     520          522          513          406         |476          419          509          430          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.138      P=0.005 **   P=0.055      P=0.042 *   |P=0.077      P=0.317      P=0.012 *    P=0.120      |
|POLY 3             |     P<0.001 **   P=0.004 **   P=0.004 **   P<0.001 **  |P=0.011 *    P=0.323      P=0.081      P=0.045 *    |
|POLY 1.5           |     P<0.001 **   P=0.008 **   P=0.005 **   P<0.001 **  |P=0.020 *    P=0.347      P=0.101      P=0.057      |
|POLY 6             |     P<0.001 **   P=0.003 **   P=0.004 **   P<0.001 **  |P=0.011 *    P=0.297      P=0.070      P=0.050      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.006 **   P=0.005 **   P<0.001 **  |P=0.012 *    P=0.349      P=0.120      P=0.038 *    |
|COCH-ARM / FISHERS |     P=0.005 **   P=0.033 *    P=0.017 *    P=0.006 **  |P=0.279      P=0.590      P=0.371      P=0.371      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     38/50 (76%)  47/50 (94%)  46/49 (94%)  47/50 (94%) |41/49 (84%)  42/50 (84%)  45/50 (90%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|     80.1%        98.9%        98.5%        100.0%      |89.9%        94.6%        99.6%        99.5%        |
|TERMINAL (d)       |     29/35 (83%)  28/28 (100%) 34/34 (100%) 35/35 (100%)|29/32 (91%)  29/30 (97%)  22/22 (100%) 29/29 (100%) |
|FIRST INCIDENCE    |     520          522          513          406         |476          419          509          430          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.213      P=0.003 **   P=0.055      P=0.059     |P=0.075      P=0.317      P=0.008 **   P=0.120      |
|POLY 3             |     P<0.001 **   P=0.002 **   P=0.003 **   P<0.001 **  |P=0.009 **   P=0.323      P=0.042 *    P=0.045 *    |
|POLY 1.5           |     P<0.001 **   P=0.002 **   P=0.003 **   P<0.001 **  |P=0.015 *    P=0.347      P=0.045 *    P=0.057      |
|POLY 6             |     P<0.001 **   P=0.002 **   P=0.003 **   P<0.001 **  |P=0.009 **   P=0.297      P=0.049 *    P=0.050      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.002 **   P=0.003 **   P<0.001 **  |P=0.010 *    P=0.349      P=0.051      P=0.038 *    |
|COCH-ARM / FISHERS |     P=0.011 *    P=0.011 *    P=0.013 *    P=0.011 *   |P=0.265      P=0.590      P=0.264      P=0.371      |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/49 (24%)  5/50 (10%)   8/49 (16%)   8/50 (16%)  |2/50 (4%)    3/50 (6%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     27.0%        11.9%        18.5%        18.3%       |4.7%         7.2%         0.0%         7.8%         |
|TERMINAL (d)       |     9/35 (26%)   4/28 (14%)   6/34 (18%)   6/35 (17%)  |2/32 (6%)    1/30 (3%)    0/22 (0%)    2/29 (7%)    |
|FIRST INCIDENCE    |     520          546          526          639         |729 (T)      555          ---          703          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.278N     P=0.124N     P=0.258N     P=0.235N    |P=0.447      P=0.476      P=0.324N     P=0.450      |
|POLY 3             |     P=0.303N     P=0.065N     P=0.245N     P=0.239N    |P=0.463      P=0.486      P=0.254N     P=0.455      |
|POLY 1.5           |     P=0.317N     P=0.059N     P=0.243N     P=0.244N    |P=0.471      P=0.483      P=0.250N     P=0.463      |
|POLY 6             |     P=0.279N     P=0.075N     P=0.245N     P=0.227N    |P=0.455      P=0.491      P=0.261N     P=0.450      |
|LOGISTIC REGRESSION|     P=0.317N     P=0.062N     P=0.241N     P=0.233N    |P=0.473      P=0.493      (e)          P=0.444      |
|COCH-ARM / FISHERS |     P=0.303N     P=0.049N*    P=0.226N     P=0.212N    |P=0.500      P=0.500      P=0.247N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    1/49 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.3%         4.8%         2.4%         2.3%        |4.7%         2.5%         5.0%         7.6%         |
|TERMINAL (d)       |     0/35 (0%)    2/28 (7%)    1/34 (3%)    1/35 (3%)   |1/32 (3%)    1/30 (3%)    1/22 (5%)    0/29 (0%)    |
|FIRST INCIDENCE    |     672          722 (T)      722 (T)      722 (T)     |662          729 (T)      727          595          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.507N     P=0.442      P=0.751      P=0.755N    |P=0.278      P=0.524N     P=0.580      P=0.455      |
|POLY 3             |     P=0.535N     P=0.481      P=0.753      P=0.757     |P=0.287      P=0.521N     P=0.665      P=0.460      |
|POLY 1.5           |     P=0.538N     P=0.490      P=0.755      P=0.756     |P=0.291      P=0.518N     P=0.672      P=0.466      |
|POLY 6             |     P=0.531N     P=0.468      P=0.752      P=0.760     |P=0.285      P=0.524N     P=0.652      P=0.458      |
|LOGISTIC REGRESSION|     P=0.518N     P=0.475      P=0.758      P=0.761     |P=0.285      P=0.518N     P=0.661      P=0.481      |
|COCH-ARM / FISHERS |     P=0.526N     P=0.508      P=0.753N     P=0.747N    |P=0.313      P=0.500N     P=0.691N     P=0.500      |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/49 (27%)  7/50 (14%)   9/49 (18%)   8/50 (16%)  |4/50 (8%)    4/50 (8%)    2/50 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     29.1%        16.6%        20.8%        18.3%       |9.3%         9.6%         5.0%         12.7%        |
|TERMINAL (d)       |     9/35 (26%)   6/28 (21%)   7/34 (21%)   6/35 (17%)  |3/32 (9%)    2/30 (7%)    1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     520          546          526          639         |662          555          727          595          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.175N     P=0.221N     P=0.270N     P=0.172N    |P=0.382      P=0.609      P=0.495N     P=0.439      |
|POLY 3             |     P=0.197N     P=0.130N     P=0.258N     P=0.174N    |P=0.399      P=0.624      P=0.374N     P=0.445      |
|POLY 1.5           |     P=0.208N     P=0.116N     P=0.254N     P=0.178N    |P=0.408      P=0.622      P=0.365N     P=0.453      |
|POLY 6             |     P=0.179N     P=0.151N     P=0.262N     P=0.167N    |P=0.392      P=0.627      P=0.391N     P=0.442      |
|LOGISTIC REGRESSION|     P=0.204N     P=0.121N     P=0.250N     P=0.168N    |P=0.407      P=0.627      P=0.395N     P=0.448      |
|COCH-ARM / FISHERS |     P=0.193N     P=0.096N     P=0.234N     P=0.150N    |P=0.446      P=0.643N     P=0.339N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         2.3%         0.0%        |0.0%         4.9%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/35 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          561          637          ---         |---          599          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.593N     P=0.487      P=0.495      (e)         |P=0.423N     P=0.231      (e)          (e)          |
|POLY 3             |     P=0.604N     P=0.488      P=0.496      (e)         |P=0.431N     P=0.228      (e)          (e)          |
|POLY 1.5           |     P=0.606N     P=0.492      P=0.496      (e)         |P=0.427N     P=0.228      (e)          (e)          |
|POLY 6             |     P=0.601N     P=0.483      P=0.496      (e)         |P=0.436N     P=0.230      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.571N     P=0.535      P=0.510      (e)         |P=0.403N     P=0.241      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/47 (9%)    3/49 (6%)    1/46 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |9.9%         7.6%         2.7%         0.0%         |
|TERMINAL (d)       |                                                        |4/32 (13%)   2/29 (7%)    1/21 (5%)    0/29 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      696          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.038N*    P=0.551N     P=0.324N     P=0.075N     |
|POLY 3             |                                                        |P=0.029N*    P=0.513N     P=0.210N     P=0.069N     |
|POLY 1.5           |                                                        |P=0.028N*    P=0.508N     P=0.204N     P=0.066N     |
|POLY 6             |                                                        |P=0.030N*    P=0.520N     P=0.220N     P=0.072N     |
|LOGISTIC REGRESSION|                                                        |P=0.034N*    P=0.535N     P=0.324N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.024N*    P=0.476N     P=0.187N     P=0.054N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/47 (0%)    0/45 (0%)    0/49 (0%)   |8/47 (17%)   9/44 (20%)   6/42 (14%)   2/46 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |19.7%        25.0%        17.1%        5.7%         |
|TERMINAL (d)       |     0/34 (0%)    0/26 (0%)    0/32 (0%)    0/34 (0%)   |8/31 (26%)   6/26 (23%)   5/21 (24%)   2/27 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      608          700          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.044N*    P=0.362      P=0.545      P=0.068N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.391      P=0.502N     P=0.071N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.037N*    P=0.391      P=0.490N     P=0.066N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.045N*    P=0.395      P=0.520N     P=0.075N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.364      P=0.608N     P=0.068N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.026N*    P=0.440      P=0.477N     P=0.049N*    |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.7%         4.9%         7.4%         9.9%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/35 (0%)    0/35 (0%)   |2/32 (6%)    1/30 (3%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      573          556          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.185      P=0.676      P=0.402      P=0.302      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.197      P=0.679      P=0.477      P=0.311      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.200      P=0.679      P=0.480      P=0.313      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.196      P=0.681      P=0.470      P=0.310      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.224      P=0.682      P=0.488      P=0.364      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.216      P=0.691N     P=0.500      P=0.339      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    3/50 (6%)    1/47 (2%)    1/49 (2%)   |0/49 (0%)    0/50 (0%)    0/48 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         7.1%         2.4%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    2/28 (7%)    1/34 (3%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      532          722 (T)      722 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.429N     P=0.247      P=0.755      P=0.762     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.459N     P=0.292      P=0.748      P=0.755     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.463N     P=0.299      P=0.748      P=0.752     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.451N     P=0.283      P=0.750      P=0.759     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.454N     P=0.309      P=0.755      P=0.762     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.449N     P=0.316      P=0.742      P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    2/49 (4%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     4.6%         4.8%         4.7%         4.6%        |7.0%         4.9%         7.6%         7.8%         |
|TERMINAL (d)       |     2/35 (6%)    1/28 (4%)    2/34 (6%)    2/35 (6%)   |3/32 (9%)    1/30 (3%)    3/22 (14%)   3/29 (10%)   |
|FIRST INCIDENCE    |     722 (T)      677          722 (T)      722 (T)     |729 (T)      674          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.565N     P=0.625      P=0.685      P=0.695     |P=0.462      P=0.526N     P=0.481      P=0.618      |
|POLY 3             |     P=0.595N     P=0.678      P=0.683      P=0.690     |P=0.472      P=0.522N     P=0.628      P=0.615      |
|POLY 1.5           |     P=0.588      P=0.686      P=0.685      P=0.687     |P=0.483      P=0.522N     P=0.636      P=0.624      |
|POLY 6             |     P=0.586N     P=0.667      P=0.682      P=0.693N    |P=0.463      P=0.522N     P=0.614      P=0.609      |
|LOGISTIC REGRESSION|     P=0.572N     P=0.662      P=0.685      P=0.695     |P=0.456      P=0.527N     P=0.481      P=0.618      |
|COCH-ARM / FISHERS |     P=0.591N     P=0.684N     P=0.691N     P=0.684N    |P=0.521      P=0.500N     P=0.661N     P=0.661N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         2.5%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |0/32 (0%)    1/30 (3%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |                                                        |151          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.118N     P=0.519N     P=0.275N     P=0.259N     |
|POLY 3             |                                                        |P=0.105N     P=0.527N     P=0.259N     P=0.266N     |
|POLY 1.5           |                                                        |P=0.103N     P=0.524N     P=0.255N     P=0.261N     |
|POLY 6             |                                                        |P=0.106N     P=0.530N     P=0.267N     P=0.270N     |
|LOGISTIC REGRESSION|                                                        |P=0.084N     P=0.443N     P=0.165N     P=0.154N     |
|COCH-ARM / FISHERS |                                                        |P=0.101N     P=0.500N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.2%         4.6%         2.3%        |0.0%         0.0%         2.5%         7.7%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    2/35 (6%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     ---          680          722 (T)      722 (T)     |---          ---          729 (T)      615          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.580      P=0.095      P=0.238      P=0.500     |P=0.018 *    (e)          P=0.425      P=0.105      |
|POLY 3             |     P=0.536      P=0.107      P=0.231      P=0.493     |P=0.017 *    (e)          P=0.485      P=0.103      |
|POLY 1.5           |     P=0.531      P=0.111      P=0.232      P=0.492     |P=0.017 *    (e)          P=0.489      P=0.105      |
|POLY 6             |     P=0.545      P=0.102      P=0.230      P=0.497     |P=0.016 *    (e)          P=0.479      P=0.101      |
|LOGISTIC REGRESSION|     P=0.566      P=0.103      P=0.238      P=0.500     |P=0.017 *    (e)          P=0.425      P=0.107      |
|COCH-ARM / FISHERS |     P=0.556      P=0.121      P=0.247      P=0.500     |P=0.020 *    (e)          P=0.500      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         9.4%         4.6%         2.3%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    2/28 (7%)    1/35 (3%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     706          532          630          722 (T)     |---          ---          723          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.254N     P=0.265      P=0.688      P=0.503N    |P=0.674      (e)          P=0.443      (e)          |
|POLY 3             |     P=0.276N     P=0.313      P=0.686      P=0.512N    |P=0.659      (e)          P=0.485      (e)          |
|POLY 1.5           |     P=0.279N     P=0.321      P=0.686      P=0.514N    |P=0.666      (e)          P=0.489      (e)          |
|POLY 6             |     P=0.269N     P=0.303      P=0.687      P=0.507N    |P=0.656      (e)          P=0.479      (e)          |
|LOGISTIC REGRESSION|     P=0.268N     P=0.333      P=0.688      P=0.501N    |P=0.677      (e)          P=0.464      (e)          |
|COCH-ARM / FISHERS |     P=0.263N     P=0.339      P=0.691N     P=0.500N    |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   4/50 (8%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     4.5%         16.4%        9.2%         2.3%        |0.0%         0.0%         5.0%         7.7%         |
|TERMINAL (d)       |     1/35 (3%)    3/28 (11%)   3/35 (9%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     706          532          630          722 (T)     |---          ---          723          615          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188N     P=0.053      P=0.336      P=0.503N    |P=0.025 *    (e)          P=0.171      P=0.105      |
|POLY 3             |     P=0.215N     P=0.067      P=0.327      P=0.512N    |P=0.022 *    (e)          P=0.221      P=0.103      |
|POLY 1.5           |     P=0.219N     P=0.071      P=0.328      P=0.514N    |P=0.023 *    (e)          P=0.225      P=0.105      |
|POLY 6             |     P=0.206N     P=0.062      P=0.327      P=0.507N    |P=0.022 *    (e)          P=0.214      P=0.101      |
|LOGISTIC REGRESSION|     P=0.207N     P=0.073      P=0.324      P=0.501N    |P=0.023 *    (e)          P=0.187      P=0.107      |
|COCH-ARM / FISHERS |     P=0.200N     P=0.080      P=0.339      P=0.500N    |P=0.028 *    (e)          P=0.247      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.7%         2.3%         0.0%        |4.5%         4.9%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/35 (3%)    0/35 (0%)   |0/32 (0%)    2/30 (7%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     653          237          722 (T)      ---         |375          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.245N     P=0.477      P=0.755      P=0.500N    |P=0.105N     P=0.666      P=0.252N     P=0.266N     |
|POLY 3             |     P=0.258N     P=0.483      P=0.753      P=0.508N    |P=0.096N     P=0.664      P=0.260N     P=0.267N     |
|POLY 1.5           |     P=0.259N     P=0.490      P=0.755      P=0.509N    |P=0.094N     P=0.669      P=0.254N     P=0.260N     |
|POLY 6             |     P=0.255N     P=0.473      P=0.752      P=0.506N    |P=0.100N     P=0.659      P=0.270N     P=0.273N     |
|LOGISTIC REGRESSION|     P=0.200N     P=0.588      P=0.760      P=0.495N    |P=0.081N     P=0.679N     P=0.187N     P=0.179N     |
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |P=0.086N     P=0.691N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   4/50 (8%)    1/50 (2%)   |8/50 (16%)   9/50 (18%)   4/50 (8%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     8.8%         11.5%        9.0%         2.3%        |18.0%        22.0%        9.8%         15.3%        |
|TERMINAL (d)       |     2/35 (6%)    0/28 (0%)    3/35 (9%)    1/35 (3%)   |2/32 (6%)    7/30 (23%)   0/22 (0%)    5/29 (17%)   |
|FIRST INCIDENCE    |     542          237          226          722 (T)     |375          599          624          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.111N     P=0.437      P=0.633      P=0.187N    |P=0.328N     P=0.441      P=0.285N     P=0.481N     |
|POLY 3             |     P=0.125N     P=0.474      P=0.629      P=0.194N    |P=0.298N     P=0.428      P=0.221N     P=0.483N     |
|POLY 1.5           |     P=0.126N     P=0.484      P=0.634      P=0.195N    |P=0.282N     P=0.440      P=0.211N     P=0.462N     |
|POLY 6             |     P=0.122N     P=0.461      P=0.623      P=0.193N    |P=0.316N     P=0.413      P=0.237N     P=0.505N     |
|LOGISTIC REGRESSION|     P=0.086N     P=0.568      P=0.613N     P=0.179N    |P=0.267N     P=0.469      P=0.181N     P=0.418N     |
|COCH-ARM / FISHERS |     P=0.112N     P=0.500      P=0.643N     P=0.181N    |P=0.231N     P=0.500      P=0.178N     P=0.387N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |6/50 (12%)   7/50 (14%)   4/50 (8%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     6.6%         7.1%         6.8%         2.3%        |13.9%        17.1%        9.8%         15.3%        |
|TERMINAL (d)       |     2/35 (6%)    0/28 (0%)    2/35 (6%)    1/35 (3%)   |2/32 (6%)    5/30 (17%)   0/22 (0%)    5/29 (17%)   |
|FIRST INCIDENCE    |     542          595          226          722 (T)     |687          599          624          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.215N     P=0.602      P=0.656      P=0.312N    |P=0.535      P=0.450      P=0.499N     P=0.535      |
|POLY 3             |     P=0.233N     P=0.632      P=0.653      P=0.322N    |P=0.546N     P=0.460      P=0.407N     P=0.554      |
|POLY 1.5           |     P=0.236N     P=0.642      P=0.656      P=0.323N    |P=0.533N     P=0.463      P=0.401N     P=0.566      |
|POLY 6             |     P=0.227N     P=0.621      P=0.651      P=0.318N    |P=0.557      P=0.455      P=0.420N     P=0.542      |
|LOGISTIC REGRESSION|     P=0.201N     P=0.650N     P=0.627N     P=0.308N    |P=0.543N     P=0.458      P=0.401N     P=0.557      |
|COCH-ARM / FISHERS |     P=0.221N     P=0.661N     P=0.661N     P=0.309N    |P=0.485N     P=0.500      P=0.370N     P=0.620N     |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.3%         2.3%        |0.0%         0.0%         0.0%         5.1%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/35 (3%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          722 (T)      699         |---          ---          ---          615          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.252      (e)          P=0.500      P=0.500     |P=0.043 *    (e)          (e)          P=0.220      |
|POLY 3             |     P=0.234      (e)          P=0.494      P=0.494     |P=0.042 *    (e)          (e)          P=0.218      |
|POLY 1.5           |     P=0.230      (e)          P=0.495      P=0.492     |P=0.043 *    (e)          (e)          P=0.221      |
|POLY 6             |     P=0.243      (e)          P=0.494      P=0.497     |P=0.042 *    (e)          (e)          P=0.218      |
|LOGISTIC REGRESSION|     P=0.240      (e)          P=0.500      P=0.494     |P=0.046 *    (e)          (e)          P=0.236      |
|COCH-ARM / FISHERS |     P=0.236      (e)          P=0.500      P=0.500     |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     35/50 (70%)  42/50 (84%)  36/50 (72%)  39/50 (78%) |40/50 (80%)  41/50 (82%)  43/50 (86%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     74.7%        91.2%        77.4%        84.9%       |85.5%        91.5%        97.3%        83.7%        |
|TERMINAL (d)       |     27/35 (77%)  27/28 (96%)  28/35 (80%)  31/35 (89%) |28/32 (88%)  28/30 (93%)  22/22 (100%) 25/29 (86%)  |
|FIRST INCIDENCE    |     520          522          513          406         |151          419          509          430          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.504N     P=0.009 **   P=0.479      P=0.276     |P=0.476      P=0.325      P=0.013 *    P=0.569N     |
|POLY 3             |     P=0.275      P=0.023 *    P=0.476      P=0.157     |P=0.445N     P=0.275      P=0.035 *    P=0.527N     |
|POLY 1.5           |     P=0.248      P=0.033 *    P=0.465      P=0.145     |P=0.397N     P=0.259      P=0.052      P=0.495N     |
|POLY 6             |     P=0.313      P=0.016 *    P=0.492      P=0.175     |P=0.473N     P=0.307      P=0.026 *    P=0.540N     |
|LOGISTIC REGRESSION|     P=0.240      P=0.018 *    P=0.418      P=0.131     |P=0.385N     P=0.303      P=0.105      P=0.467N     |
|COCH-ARM / FISHERS |     P=0.368      P=0.077      P=0.500      P=0.247     |P=0.169N     P=0.500      P=0.298      P=0.241N     |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55301 TEST: 04                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  46/50 (92%)  47/50 (94%)  42/50 (84%) |26/50 (52%)  30/50 (60%)  40/50 (80%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|     46.5%        94.8%        96.4%        89.4%       |56.0%        69.7%        90.1%        99.2%        |
|TERMINAL (d)       |     13/35 (37%)  26/28 (93%)  34/35 (97%)  30/35 (86%) |14/32 (44%)  20/30 (67%)  20/22 (91%)  29/29 (100%) |
|FIRST INCIDENCE    |     542          237          226          406         |375          573          556          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.018 *    P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.217      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.128      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.145      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.117      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.190      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.273      P=0.003 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     43/50 (86%)  49/50 (98%)  48/50 (96%)  47/50 (94%) |47/50 (94%)  45/50 (90%)  45/50 (90%)  45/50 (90%)  |
|POLY-3 ADJUSTED (b)|     88.7%        100.0%       98.0%        100.0%      |96.5%        99.7%        99.6%        99.7%        |
|TERMINAL (d)       |     31/35 (89%)  28/28 (100%) 34/35 (97%)  35/35 (100%)|31/32 (97%)  30/30 (100%) 22/22 (100%) 29/29 (100%) |
|FIRST INCIDENCE    |     520          237          226          406         |151          419          509          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.531      P=0.015 *    P=0.212      P=0.280     |P=0.273      P=0.509      P=0.069      P=0.382      |
|POLY 3             |     P=0.009 **   P=0.018 *    P=0.069      P=0.021 *   |P=0.174      P=0.348      P=0.366      P=0.347      |
|POLY 1.5           |     P=0.008 **   P=0.015 *    P=0.060      P=0.018 *   |P=0.270      P=0.416      P=0.442      P=0.418      |
|POLY 6             |     P=0.012 *    P=0.022 *    P=0.084      P=0.025 *   |P=0.164      P=0.358      P=0.364      P=0.357      |
|LOGISTIC REGRESSION|     P=0.023 *    P=0.010 *    P=0.043 *    P=0.022 *   |P=0.427      P=0.691N     P=0.657N     P=0.637      |
|COCH-ARM / FISHERS |     P=0.178      P=0.030 *    P=0.080      P=0.159     |P=0.338N     P=0.357N     P=0.357N     P=0.357N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).