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TDMS Study 55301-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97

EXPERIMENT: 55301 TEST: 04                                                                                     TIME: 09:11:52
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B
PATHOLOGIST: F. VOELKER                      STEDHAM, MICHAEL                                                  CAS: 110-86-1
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97     
EXPERIMENT: 55301 TEST: 04                                                                                     TIME: 09:11:52     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B     
PATHOLOGIST: F. VOELKER                      STEDHAM, MICHAEL                                                  CAS: 110-86-1      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                     PYRIDINE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Cytoplasmic Alteration
Adrenal Cortex: Capsule                Hyperplasia
Brain                                  Mineralization
Islets, Pancreatic                     Hyperplasia
Kidney                                 Infarct
Kidney: Renal Tubule                   Dilatation
                                       Pigmentation
Liver                                  Basophilic Focus
Liver: Centrilobular                   Vacuolization Cytoplasmic
Lung                                   Infiltration Cellular Lymphocyte
Nose: Olfactory Epithelium             Degeneration Hyaline
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
Spleen                                 Hematopoietic Cell Proliferation
Thymus                                 Atrophy
Thyroid Gland: Follicular Cell         Hyperplasia
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Bone                                   Fibrous Osteodystrophy
Clitoral Gland                         Cyst
Islets, Pancreatic                     Hyperplasia
Liver                                  Eosinophilic Focus
                                       Infiltration Cellular Lymphocyte
                                       Mixed Cell Focus
Lung: Alveolar Epithelium              Hyperplasia
Nose: Olfactory Epithelium             Degeneration Hyaline
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
Salivary Glands                        Infiltration Cellular Lymphocyte
Spleen                                 Hematopoietic Cell Proliferation
Thyroid Gland: Follicle                Cyst
Thyroid Gland: Follicular Cell         Hyperplasia
Urinary Bladder                        Infiltration Cellular Lymphocyte
Uterus                                 Hyperplasia Cystic
===============================================================
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Cytoplasmic Alteration                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/49 (37%)  13/49 (27%)  9/49 (18%)   11/49 (22%) |2/49 (4%)    0/50 (0%)    0/48 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     40.5%        30.9%        21.3%        26.1%       |4.8%         0.0%         0.0%         5.2%         |
|TERMINAL (d)       |     16/35 (46%)  9/27 (33%)   9/34 (27%)   11/34 (32%) |2/32 (6%)    0/30 (0%)    0/22 (0%)    2/29 (7%)    |
|FIRST INCIDENCE    |     598          522          722 (T)      722 (T)     |729 (T)      ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054N     P=0.461N     P=0.037N*    P=0.098N    |P=0.464      P=0.252N     P=0.324N     P=0.660      |
|POLY 3             |     P=0.079N     P=0.236N     P=0.041N*    P=0.114N    |P=0.495      P=0.244N     P=0.256N     P=0.666      |
|POLY 1.5           |     P=0.083N     P=0.222N     P=0.039N*    P=0.116N    |P=0.498      P=0.243N     P=0.254N     P=0.672      |
|POLY 6             |     P=0.073N     P=0.257N     P=0.043N*    P=0.108N    |P=0.492      P=0.245N     P=0.262N     P=0.660      |
|LOGISTIC REGRESSION|     P=0.067N     P=0.258N     P=0.039N*    P=0.090N    |P=0.464      (e)          (e)          P=0.660      |
|COCH-ARM / FISHERS |     P=0.072N     P=0.193N     P=0.035N*    P=0.092N    |P=0.503      P=0.242N     P=0.253N     P=0.684N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)   |1/49 (2%)    0/50 (0%)    0/48 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.4%         0.0%         0.0%         5.1%         |
|TERMINAL (d)       |     0/35 (0%)    0/27 (0%)    0/34 (0%)    0/34 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |476          ---          ---          690          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.228      P=0.513N     P=0.509N     P=0.463      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.240      P=0.510N     P=0.521N     P=0.469      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.242      P=0.508N     P=0.517N     P=0.476      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.238      P=0.512N     P=0.526N     P=0.464      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.253      P=0.447N     P=0.455N     P=0.521      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.249      P=0.495N     P=0.505N     P=0.508      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    1/49 (2%)    2/49 (4%)    0/49 (0%)   |1/49 (2%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         2.5%         4.7%         0.0%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    1/27 (4%)    2/34 (6%)    0/34 (0%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.193N     P=0.591N     P=0.685      P=0.245N    |P=0.327N     P=0.513N     P=0.575N     P=0.520N     |
|POLY 3             |     P=0.202N     P=0.526N     P=0.683      P=0.245N    |P=0.294N     P=0.506N     P=0.517N     P=0.516N     |
|POLY 1.5           |     P=0.206N     P=0.517N     P=0.685      P=0.247N    |P=0.296N     P=0.506N     P=0.515N     P=0.512N     |
|POLY 6             |     P=0.194N     P=0.538N     P=0.682      P=0.241N    |P=0.294N     P=0.507N     P=0.522N     P=0.519N     |
|LOGISTIC REGRESSION|     P=0.193N     P=0.591N     P=0.685      (e)         |P=0.327N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.200N     P=0.500N     P=0.691N     P=0.247N    |P=0.305N     P=0.495N     P=0.505N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    0/49 (0%)    1/49 (2%)   |0/49 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/27 (0%)    0/34 (0%)    0/34 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     663          ---          ---          709         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.446N     P=0.280N     P=0.252N     P=0.497N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.449N     P=0.255N     P=0.245N     P=0.513N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.453N     P=0.249N     P=0.243N     P=0.515N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.444N     P=0.264N     P=0.247N     P=0.509N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.465N     P=0.247N     P=0.241N     P=0.511N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.461N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Capsule                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/49 (86%)  29/49 (59%)  30/49 (61%)  29/49 (59%) |41/49 (84%)  35/50 (70%)  39/48 (81%)  37/50 (74%)  |
|POLY-3 ADJUSTED (b)|     89.3%        65.7%        67.7%        67.2%       |90.7%        81.3%        92.7%        87.8%        |
|TERMINAL (d)       |     32/35 (91%)  19/27 (70%)  24/34 (71%)  25/34 (74%) |30/32 (94%)  27/30 (90%)  22/22 (100%) 27/29 (93%)  |
|FIRST INCIDENCE    |     520          522          513          624         |554          573          417          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.013N*    P=0.201N     P=0.028N*    P=0.012N*   |P=0.346      P=0.299N     P=0.059      P=0.574      |
|POLY 3             |     P=0.021N*    P=0.004N**   P=0.007N**   P=0.007N**  |P=0.554      P=0.152N     P=0.520      P=0.458N     |
|POLY 1.5           |     P=0.022N*    P=0.003N**   P=0.006N**   P=0.006N**  |P=0.508N     P=0.137N     P=0.554      P=0.383N     |
|POLY 6             |     P=0.020N*    P=0.005N**   P=0.009N**   P=0.007N**  |P=0.500      P=0.183N     P=0.447      P=0.531N     |
|LOGISTIC REGRESSION|     P=0.015N*    P=0.006N**   P=0.007N**   P=0.004N**  |P=0.492      P=0.127N     P=0.539      P=0.470N     |
|COCH-ARM / FISHERS |     P=0.014N*    P=0.003N**   P=0.006N**   P=0.003N**  |P=0.285N     P=0.084N     P=0.481N     P=0.176N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |1/49 (2%)    2/49 (4%)    0/45 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.4%         5.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/27 (0%)    0/34 (0%)    0/34 (0%)   |1/32 (3%)    2/30 (7%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.217N     P=0.477      P=0.575N     P=0.520N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.208N     P=0.482      P=0.531N     P=0.520N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.206N     P=0.483      P=0.529N     P=0.517N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.211N     P=0.481      P=0.534N     P=0.523N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.217N     P=0.477      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.192N     P=0.500      P=0.521N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    5/50 (10%)   2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         12.3%        5.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    4/30 (13%)   1/22 (5%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          680          696          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.325N     P=0.028 *    P=0.187      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.334N     P=0.026 *    P=0.221      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.324N     P=0.027 *    P=0.225      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.344N     P=0.026 *    P=0.215      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.318N     P=0.028 *    P=0.215      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.279N     P=0.028 *    P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         0.0%         0.0%        |2.4%         2.5%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |1/32 (3%)    1/30 (3%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          ---         |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.113N     P=0.288N     P=0.245N     P=0.238N    |P=0.263N     P=0.748      P=0.575N     P=0.520N     |
|POLY 3             |     P=0.107N     P=0.248N     P=0.244N     P=0.239N    |P=0.241N     P=0.754      P=0.511N     P=0.516N     |
|POLY 1.5           |     P=0.108N     P=0.243N     P=0.243N     P=0.242N    |P=0.239N     P=0.754      P=0.509N     P=0.512N     |
|POLY 6             |     P=0.105N     P=0.256N     P=0.244N     P=0.236N    |P=0.243N     P=0.753      P=0.517N     P=0.519N     |
|LOGISTIC REGRESSION|     P=0.113N     (e)          (e)          (e)         |P=0.263N     P=0.748      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.114N     P=0.242N     P=0.247N     P=0.242N    |P=0.234N     P=0.747N     P=0.500N     P=0.495N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow: Myeloid Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.3%         2.4%         0.0%         2.3%        |2.4%         0.0%         0.0%         5.1%         |
|TERMINAL (d)       |     1/35 (3%)    1/28 (4%)    0/34 (0%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      ---          722 (T)     |568          ---          ---          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.597N     P=0.712      P=0.506N     P=0.762     |P=0.232      P=0.505N     P=0.509N     P=0.472      |
|POLY 3             |     P=0.613N     P=0.750      P=0.506N     P=0.758     |P=0.243      P=0.509N     P=0.514N     P=0.476      |
|POLY 1.5           |     P=0.614N     P=0.755      P=0.505N     P=0.756     |P=0.244      P=0.507N     P=0.510N     P=0.481      |
|POLY 6             |     P=0.611N     P=0.742      P=0.507N     P=0.760N    |P=0.241      P=0.511N     P=0.521N     P=0.472      |
|LOGISTIC REGRESSION|     P=0.597N     P=0.712      (e)          P=0.762     |P=0.262      P=0.474N     P=0.479N     P=0.542      |
|COCH-ARM / FISHERS |     P=0.612N     P=0.747N     P=0.500N     P=0.747N    |P=0.249      P=0.495N     P=0.500N     P=0.508      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  27/50 (54%)  30/49 (61%)  35/50 (70%) |25/50 (50%)  27/50 (54%)  18/50 (36%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     84.7%        58.5%        65.8%        77.8%       |55.2%        62.5%        41.9%        45.1%        |
|TERMINAL (d)       |     30/35 (86%)  16/28 (57%)  20/34 (59%)  27/35 (77%) |17/32 (53%)  18/30 (60%)  7/22 (32%)   11/29 (38%)  |
|FIRST INCIDENCE    |     520          237          514          594         |476          372          417          366          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.239N     P=0.119N     P=0.067N     P=0.182N    |P=0.204N     P=0.321      P=0.467N     P=0.311N     |
|POLY 3             |     P=0.469N     P=0.003N**   P=0.025N*    P=0.273N    |P=0.094N     P=0.313      P=0.147N     P=0.232N     |
|POLY 1.5           |     P=0.464N     P=0.002N**   P=0.023N*    P=0.250N    |P=0.089N     P=0.322      P=0.142N     P=0.219N     |
|POLY 6             |     P=0.453N     P=0.004N**   P=0.027N*    P=0.286N    |P=0.102N     P=0.300      P=0.161N     P=0.248N     |
|LOGISTIC REGRESSION|     P=0.394N     P=0.004N**   P=0.024N*    P=0.195N    |P=0.100N     P=0.327      P=0.147N     P=0.222N     |
|COCH-ARM / FISHERS |     P=0.321N     P=0.002N**   P=0.019N*    P=0.121N    |P=0.065N     P=0.421      P=0.113N     P=0.157N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |45/47 (96%)  43/48 (90%)  45/48 (94%)  43/45 (96%)  |
|POLY-3 ADJUSTED (b)|                                                        |97.5%        97.7%        100.0%       99.7%        |
|TERMINAL (d)       |                                                        |29/30 (97%)  28/29 (97%)  21/21 (100%) 27/27 (100%) |
|FIRST INCIDENCE    |                                                        |64           372          417          188          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.253      P=0.562N     P=0.053      P=0.385      |
|POLY 3             |                                                        |P=0.253      P=0.743      P=0.457      P=0.513      |
|POLY 1.5           |                                                        |P=0.277      P=0.711      P=0.419      P=0.517      |
|POLY 6             |                                                        |P=0.245      P=0.754N     P=0.497      P=0.513      |
|LOGISTIC REGRESSION|                                                        |P=0.401      P=0.413N     P=0.677N     P=0.661      |
|COCH-ARM / FISHERS |                                                        |P=0.445      P=0.226N     P=0.510N     P=0.675N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/47 (6%)    0/48 (0%)    0/48 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |7.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |3/30 (10%)   0/29 (0%)    0/21 (0%)    0/27 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.061N     P=0.126N     P=0.189N     P=0.139N     |
|POLY 3             |                                                        |P=0.044N*    P=0.122N     P=0.123N     P=0.137N     |
|POLY 1.5           |                                                        |P=0.044N*    P=0.122N     P=0.121N     P=0.134N     |
|POLY 6             |                                                        |P=0.045N*    P=0.121N     P=0.129N     P=0.139N     |
|LOGISTIC REGRESSION|                                                        |P=0.061N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.048N*    P=0.117N     P=0.117N     P=0.129N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/47 (9%)    2/48 (4%)    4/48 (8%)    4/45 (9%)    |
|POLY-3 ADJUSTED (b)|                                                        |10.0%        5.1%         10.0%        11.1%        |
|TERMINAL (d)       |                                                        |4/30 (13%)   2/29 (7%)    1/21 (5%)    4/27 (15%)   |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      417          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.388      P=0.351N     P=0.500      P=0.587      |
|POLY 3             |                                                        |P=0.410      P=0.346N     P=0.643N     P=0.587      |
|POLY 1.5           |                                                        |P=0.421      P=0.347N     P=0.640N     P=0.596      |
|POLY 6             |                                                        |P=0.402      P=0.345N     P=0.638      P=0.580      |
|LOGISTIC REGRESSION|                                                        |P=0.412      P=0.351N     P=0.641N     P=0.587      |
|COCH-ARM / FISHERS |                                                        |P=0.434      P=0.329N     P=0.631N     P=0.618      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/47 (4%)    0/48 (0%)    1/48 (2%)    3/45 (7%)    |
|POLY-3 ADJUSTED (b)|                                                        |5.0%         0.0%         2.6%         8.2%         |
|TERMINAL (d)       |                                                        |2/30 (7%)    0/29 (0%)    1/21 (5%)    2/27 (7%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      615          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.209      P=0.245N     P=0.624N     P=0.450      |
|POLY 3             |                                                        |P=0.219      P=0.241N     P=0.510N     P=0.458      |
|POLY 1.5           |                                                        |P=0.223      P=0.242N     P=0.505N     P=0.464      |
|POLY 6             |                                                        |P=0.217      P=0.241N     P=0.522N     P=0.457      |
|LOGISTIC REGRESSION|                                                        |P=0.209      (e)          P=0.624N     P=0.454      |
|COCH-ARM / FISHERS |                                                        |P=0.225      P=0.242N     P=0.492N     P=0.479      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    4/49 (8%)    4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.2%         9.6%         9.5%         9.1%        |                                                    |
|TERMINAL (d)       |     1/35 (3%)    3/28 (11%)   4/34 (12%)   2/35 (6%)   |                                                    |
|FIRST INCIDENCE    |     722 (T)      692          722 (T)      624         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.238      P=0.124      P=0.170      P=0.186     |                                                    |
|POLY 3             |     P=0.198      P=0.158      P=0.163      P=0.172     |                                                    |
|POLY 1.5           |     P=0.190      P=0.165      P=0.165      P=0.169     |                                                    |
|POLY 6             |     P=0.213      P=0.149      P=0.161      P=0.180     |                                                    |
|LOGISTIC REGRESSION|     P=0.207      P=0.136      P=0.170      P=0.171     |                                                    |
|COCH-ARM / FISHERS |     P=0.205      P=0.181      P=0.175      P=0.181     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.2%         2.4%         0.0%         7.0%        |                                                    |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    0/34 (0%)    3/35 (9%)   |                                                    |
|FIRST INCIDENCE    |     706          722 (T)      ---          722 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.179      P=0.708      P=0.505N     P=0.304     |                                                    |
|POLY 3             |     P=0.158      P=0.744      P=0.511N     P=0.293     |                                                    |
|POLY 1.5           |     P=0.156      P=0.750      P=0.509N     P=0.291     |                                                    |
|POLY 6             |     P=0.161      P=0.736      P=0.512N     P=0.297     |                                                    |
|LOGISTIC REGRESSION|     P=0.174      P=0.733      P=0.510N     P=0.304     |                                                    |
|COCH-ARM / FISHERS |     P=0.160      P=0.753N     P=0.505N     P=0.309     |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.0%         0.0%         0.0%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          546          ---          ---         |---          ---          692          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.316N     P=0.110      (e)          (e)         |P=0.677      (e)          P=0.483      (e)          |
|POLY 3             |     P=0.325N     P=0.111      (e)          (e)         |P=0.659      (e)          P=0.486      (e)          |
|POLY 1.5           |     P=0.325N     P=0.113      (e)          (e)         |P=0.666      (e)          P=0.489      (e)          |
|POLY 6             |     P=0.324N     P=0.109      (e)          (e)         |P=0.656      (e)          P=0.480      (e)          |
|LOGISTIC REGRESSION|     P=0.283N     P=0.138      (e)          (e)         |P=0.686      (e)          P=0.490      (e)          |
|COCH-ARM / FISHERS |     P=0.312N     P=0.121      (e)          (e)         |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     598          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117N     P=0.280N     P=0.248N     P=0.245N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.108N     P=0.256N     P=0.251N     P=0.247N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.110N     P=0.249N     P=0.249N     P=0.248N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.106N     P=0.265N     P=0.253N     P=0.244N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.114N     P=0.231N     P=0.236N     P=0.232N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.253N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum: Lymphoid Tissue                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/44 (0%)    2/42 (5%)    1/45 (2%)   |0/44 (0%)    0/49 (0%)    0/40 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.3%         2.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    2/34 (6%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          722 (T)      722 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265      (e)          P=0.232      P=0.500     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.244      (e)          P=0.212      P=0.490     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.234      (e)          P=0.210      P=0.486     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.258      (e)          P=0.216      P=0.496     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.232      P=0.500     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.241      (e)          P=0.220      P=0.489     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Jejunum: Peyer's Patch                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/40 (3%)    1/46 (2%)    3/42 (7%)    1/44 (2%)   |1/42 (2%)    0/47 (0%)    0/38 (0%)    0/43 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         2.6%         8.0%         2.5%        |2.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    1/28 (4%)    3/33 (9%)    1/35 (3%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      722 (T)     |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.578      P=0.712      P=0.284      P=0.762     |P=0.327N     P=0.513N     P=0.575N     P=0.520N     |
|POLY 3             |     P=0.580      P=0.757N     P=0.304      P=0.746N    |P=0.289N     P=0.497N     P=0.527N     P=0.522N     |
|POLY 1.5           |     P=0.570      P=0.748N     P=0.306      P=0.747N    |P=0.294N     P=0.493N     P=0.524N     P=0.514N     |
|POLY 6             |     P=0.589      P=0.753      P=0.301      P=0.746N    |P=0.285N     P=0.503N     P=0.534N     P=0.528N     |
|LOGISTIC REGRESSION|     P=0.578      P=0.712      P=0.284      P=0.762     |P=0.327N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.575      P=0.717N     P=0.327      P=0.729N    |P=0.310N     P=0.472N     P=0.525N     P=0.494N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    5/50 (10%)   2/48 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    2/47 (4%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         11.7%        4.8%         0.0%        |0.0%         0.0%         5.2%         7.8%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    2/34 (6%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    2/22 (9%)    1/29 (3%)    |
|FIRST INCIDENCE    |     ---          561          722 (T)      ---         |---          ---          729 (T)      595          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.272N     P=0.027 *    P=0.232      (e)         |P=0.025 *    (e)          P=0.160      P=0.106      |
|POLY 3             |     P=0.292N     P=0.028 *    P=0.227      (e)         |P=0.022 *    (e)          P=0.217      P=0.103      |
|POLY 1.5           |     P=0.295N     P=0.030 *    P=0.227      (e)         |P=0.023 *    (e)          P=0.220      P=0.105      |
|POLY 6             |     P=0.285N     P=0.027 *    P=0.227      (e)         |P=0.022 *    (e)          P=0.211      P=0.103      |
|LOGISTIC REGRESSION|     P=0.277N     P=0.037 *    P=0.232      (e)         |P=0.023 *    (e)          P=0.160      P=0.112      |
|COCH-ARM / FISHERS |     P=0.276N     P=0.030 *    P=0.242      (e)         |P=0.028 *    (e)          P=0.237      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    2/50 (4%)    4/48 (8%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     9.1%         4.8%         9.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/35 (9%)    2/28 (7%)    4/34 (12%)   0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     542          722 (T)      722 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.071N     P=0.429N     P=0.625      P=0.067N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.077N     P=0.366N     P=0.610      P=0.063N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.080N     P=0.353N     P=0.615      P=0.064N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.072N     P=0.385N     P=0.607      P=0.062N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.077N     P=0.347N     P=0.621      P=0.061N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.076N     P=0.329N     P=0.631      P=0.056N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    2/48 (4%)    6/50 (12%)  |1/49 (2%)    2/50 (4%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         2.4%         4.8%         13.9%       |2.4%         4.9%         2.6%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    1/28 (4%)    2/34 (6%)    5/35 (14%)  |1/32 (3%)    2/30 (7%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      699         |729 (T)      729 (T)      699          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043 *    P=0.578N     P=0.685      P=0.135     |P=0.283N     P=0.477      P=0.701      P=0.520N     |
|POLY 3             |     P=0.034 *    P=0.517N     P=0.677      P=0.129     |P=0.271N     P=0.489      P=0.745      P=0.516N     |
|POLY 1.5           |     P=0.032 *    P=0.509N     P=0.678      P=0.127     |P=0.266N     P=0.490      P=0.748      P=0.512N     |
|POLY 6             |     P=0.036 *    P=0.529N     P=0.678      P=0.134     |P=0.276N     P=0.487      P=0.738      P=0.519N     |
|LOGISTIC REGRESSION|     P=0.042 *    P=0.578N     P=0.685      P=0.139     |P=0.274N     P=0.477      P=0.740      (e)          |
|COCH-ARM / FISHERS |     P=0.035 *    P=0.492N     P=0.684      P=0.141     |P=0.249N     P=0.508      P=0.753N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    1/50 (2%)    2/48 (4%)    6/50 (12%)  |4/49 (8%)    2/50 (4%)    5/49 (10%)   2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     6.9%         2.4%         4.8%         13.6%       |9.5%         4.9%         12.6%        5.2%         |
|TERMINAL (d)       |     3/35 (9%)    1/28 (4%)    2/34 (6%)    5/35 (14%)  |3/32 (9%)    1/30 (3%)    4/22 (18%)   1/29 (3%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      406         |670          642          417          703          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.095      P=0.387N     P=0.513N     P=0.240     |P=0.434N     P=0.369N     P=0.315      P=0.388N     |
|POLY 3             |     P=0.085      P=0.323N     P=0.521N     P=0.245     |P=0.408N     P=0.350N     P=0.463      P=0.375N     |
|POLY 1.5           |     P=0.080      P=0.314N     P=0.520N     P=0.239     |P=0.397N     P=0.349N     P=0.471      P=0.366N     |
|POLY 6             |     P=0.091      P=0.335N     P=0.521N     P=0.255     |P=0.418N     P=0.351N     P=0.443      P=0.383N     |
|LOGISTIC REGRESSION|     P=0.079      P=0.387N     P=0.513N     P=0.241     |P=0.396N     P=0.349N     P=0.471      P=0.378N     |
|COCH-ARM / FISHERS |     P=0.082      P=0.301N     P=0.510N     P=0.254     |P=0.370N     P=0.329N     P=0.500      P=0.339N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     633          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.116N     P=0.259N     P=0.251N     P=0.237N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.107N     P=0.251N     P=0.250N     P=0.242N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.109N     P=0.244N     P=0.248N     P=0.243N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.104N     P=0.261N     P=0.252N     P=0.241N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.112N     P=0.224N     P=0.235N     P=0.225N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.115N     P=0.242N     P=0.253N     P=0.242N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    3/50 (6%)    0/48 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         7.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     542          546          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.077N     P=0.449      P=0.256N     P=0.244N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.076N     P=0.476      P=0.252N     P=0.243N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.076N     P=0.488      P=0.249N     P=0.244N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.076N     P=0.461      P=0.254N     P=0.242N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.066N     P=0.536      P=0.220N     P=0.204N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.072N     P=0.510      P=0.253N     P=0.242N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     34/49 (69%)  27/50 (54%)  25/48 (52%)  32/50 (64%) |5/49 (10%)   10/50 (20%)  7/49 (14%)   8/49 (16%)   |
|POLY-3 ADJUSTED (b)|     73.8%        61.7%        59.5%        73.2%       |11.9%        24.6%        17.8%        20.5%        |
|TERMINAL (d)       |     28/35 (80%)  20/28 (71%)  23/34 (68%)  29/35 (83%) |4/32 (13%)   9/30 (30%)   4/22 (18%)   7/29 (24%)   |
|FIRST INCIDENCE    |     520          532          630          594         |691          680          659          626          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.323N     P=0.496N     P=0.063N     P=0.418N    |P=0.277      P=0.101      P=0.196      P=0.210      |
|POLY 3             |     P=0.493      P=0.149N     P=0.107N     P=0.570N    |P=0.295      P=0.112      P=0.331      P=0.227      |
|POLY 1.5           |     P=0.504      P=0.122N     P=0.089N     P=0.539N    |P=0.311      P=0.115      P=0.341      P=0.237      |
|POLY 6             |     P=0.486      P=0.190N     P=0.131N     P=0.603N    |P=0.282      P=0.108      P=0.314      P=0.219      |
|LOGISTIC REGRESSION|     P=0.432N     P=0.154N     P=0.070N     P=0.432N    |P=0.284      P=0.107      P=0.299      P=0.214      |
|COCH-ARM / FISHERS |     P=0.451N     P=0.086N     P=0.062N     P=0.361N    |P=0.363      P=0.140      P=0.380      P=0.276      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Artery                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.113N     P=0.288N     P=0.245N     P=0.238N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.107N     P=0.248N     P=0.248N     P=0.239N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.109N     P=0.243N     P=0.247N     P=0.242N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.105N     P=0.256N     P=0.247N     P=0.236N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.113N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.115N     P=0.242N     P=0.253N     P=0.242N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    2/48 (4%)    5/50 (10%)  |0/49 (0%)    1/50 (2%)    2/49 (4%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         4.7%         10.8%       |0.0%         2.4%         4.9%         5.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          645          3            3           |---          4            3            15           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009 **   P=0.485      P=0.240      P=0.036 *   |P=0.158      P=0.500      P=0.237      P=0.228      |
|POLY 3             |     P=0.009 **   P=0.491      P=0.234      P=0.036 *   |P=0.150      P=0.499      P=0.231      P=0.229      |
|POLY 1.5           |     P=0.008 **   P=0.496      P=0.233      P=0.035 *   |P=0.153      P=0.499      P=0.234      P=0.232      |
|POLY 6             |     P=0.010 *    P=0.486      P=0.235      P=0.038 *   |P=0.148      P=0.498      P=0.225      P=0.228      |
|LOGISTIC REGRESSION|     P=0.020 *    P=0.513      P=0.314      P=0.082     |P=0.168      (e)          P=0.452      P=0.345      |
|COCH-ARM / FISHERS |     P=0.008 **   P=0.505      P=0.242      P=0.030 *   |P=0.158      P=0.505      P=0.247      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    0/50 (0%)    1/48 (2%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     6.9%         0.0%         2.4%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/35 (9%)    0/28 (0%)    0/34 (0%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          657          722 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.282N     P=0.162N     P=0.317N     P=0.305N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.284N     P=0.128N     P=0.320N     P=0.309N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.290N     P=0.123N     P=0.320N     P=0.312N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.275N     P=0.134N     P=0.317N     P=0.303N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.291N     (e)          P=0.321N     P=0.305N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.293N     P=0.117N     P=0.316N     P=0.301N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    5/50 (10%)   3/48 (6%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    3/49 (6%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         12.0%        7.1%         4.6%        |0.0%         0.0%         7.6%         5.2%         |
|TERMINAL (d)       |     0/35 (0%)    4/28 (14%)   1/34 (3%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    1/22 (5%)    1/29 (3%)    |
|FIRST INCIDENCE    |     ---          692          526          624         |---          ---          583          680          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.482      P=0.019 *    P=0.117      P=0.243     |P=0.086      (e)          P=0.097      P=0.220      |
|POLY 3             |     P=0.445      P=0.026 *    P=0.113      P=0.237     |P=0.081      (e)          P=0.109      P=0.221      |
|POLY 1.5           |     P=0.436      P=0.028 *    P=0.113      P=0.234     |P=0.084      (e)          P=0.110      P=0.224      |
|POLY 6             |     P=0.461      P=0.024 *    P=0.115      P=0.242     |P=0.079      (e)          P=0.106      P=0.218      |
|LOGISTIC REGRESSION|     P=0.455      P=0.023 *    P=0.123      P=0.242     |P=0.091      (e)          P=0.120      P=0.221      |
|COCH-ARM / FISHERS |     P=0.462      P=0.030 *    P=0.117      P=0.253     |P=0.095      (e)          P=0.121      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.7%         2.4%         0.0%         0.0%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/35 (6%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     663          680          ---          ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.044N*    P=0.368N     P=0.131N     P=0.122N    |P=0.327N     P=0.513N     P=0.575N     P=0.520N     |
|POLY 3             |     P=0.042N*    P=0.332N     P=0.129N     P=0.125N    |P=0.293N     P=0.506N     P=0.510N     P=0.516N     |
|POLY 1.5           |     P=0.043N*    P=0.322N     P=0.128N     P=0.127N    |P=0.294N     P=0.506N     P=0.507N     P=0.512N     |
|POLY 6             |     P=0.041N*    P=0.344N     P=0.130N     P=0.123N    |P=0.293N     P=0.507N     P=0.517N     P=0.519N     |
|LOGISTIC REGRESSION|     P=0.046N*    P=0.325N     P=0.129N     P=0.126N    |P=0.327N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.044N*    P=0.309N     P=0.125N     P=0.121N    |P=0.303N     P=0.495N     P=0.495N     P=0.495N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/49 (2%)    2/50 (4%)   |1/49 (2%)    5/50 (10%)   1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         7.1%         2.4%         4.6%        |2.4%         12.4%        2.5%         5.2%         |
|TERMINAL (d)       |     1/35 (3%)    1/28 (4%)    1/34 (3%)    2/35 (6%)   |1/32 (3%)    5/30 (17%)   1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     722 (T)      587          722 (T)      722 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.544      P=0.256      P=0.755      P=0.500     |P=0.578N     P=0.087      P=0.676      P=0.465      |
|POLY 3             |     P=0.510      P=0.287      P=0.749      P=0.489     |P=0.567N     P=0.093      P=0.749      P=0.472      |
|POLY 1.5           |     P=0.506      P=0.293      P=0.750      P=0.486     |P=0.557N     P=0.094      P=0.753      P=0.479      |
|POLY 6             |     P=0.518      P=0.280      P=0.748      P=0.494     |P=0.578N     P=0.091      P=0.742      P=0.467      |
|LOGISTIC REGRESSION|     P=0.518      P=0.314      P=0.755      P=0.500     |P=0.578N     P=0.087      P=0.676      P=0.465      |
|COCH-ARM / FISHERS |     P=0.525      P=0.309      P=0.747      P=0.500     |P=0.516N     P=0.107      P=0.747N     P=0.508      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     19/50 (38%)  22/50 (44%)  18/49 (37%)  15/50 (30%) |17/49 (35%)  12/50 (24%)  14/50 (28%)  9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     41.7%        49.1%        40.3%        34.5%       |38.4%        29.0%        34.6%        22.0%        |
|TERMINAL (d)       |     15/35 (43%)  12/28 (43%)  13/34 (38%)  13/35 (37%) |12/32 (38%)  9/30 (30%)   8/22 (36%)   5/29 (17%)   |
|FIRST INCIDENCE    |     633          522          513          649         |375          599          678          479          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.147      P=0.545N     P=0.266N    |P=0.139N     P=0.256N     P=0.471      P=0.109N     |
|POLY 3             |     P=0.185N     P=0.309      P=0.531N     P=0.313N    |P=0.082N     P=0.244N     P=0.445N     P=0.076N     |
|POLY 1.5           |     P=0.192N     P=0.313      P=0.541N     P=0.318N    |P=0.077N     P=0.231N     P=0.407N     P=0.071N     |
|POLY 6             |     P=0.174N     P=0.309      P=0.517N     P=0.304N    |P=0.084N     P=0.254N     P=0.494N     P=0.078N     |
|LOGISTIC REGRESSION|     P=0.170N     P=0.273      P=0.566N     P=0.277N    |P=0.079N     P=0.201N     P=0.369N     P=0.056N     |
|COCH-ARM / FISHERS |     P=0.152N     P=0.342      P=0.531N     P=0.263N    |P=0.057N     P=0.172N     P=0.308N     P=0.048N*    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/49 (2%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         2.4%         0.0%        |4.7%         2.5%         2.5%         2.6%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    1/34 (3%)    0/35 (0%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     ---          722 (T)      722 (T)      ---         |568          680          708          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.579N     P=0.455      P=0.494      (e)         |P=0.451N     P=0.520N     P=0.578N     P=0.534N     |
|POLY 3             |     P=0.605N     P=0.486      P=0.490      (e)         |P=0.425N     P=0.514N     P=0.522N     P=0.532N     |
|POLY 1.5           |     P=0.606N     P=0.491      P=0.491      (e)         |P=0.420N     P=0.511N     P=0.514N     P=0.524N     |
|POLY 6             |     P=0.601N     P=0.479      P=0.489      (e)         |P=0.432N     P=0.517N     P=0.534N     P=0.539N     |
|LOGISTIC REGRESSION|     (e)          P=0.455      P=0.494      (e)         |P=0.421N     P=0.495N     P=0.499N     P=0.509N     |
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.495      (e)         |P=0.404N     P=0.492N     P=0.492N     P=0.492N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |4/49 (8%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |9.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |2/32 (6%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |375          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.027N*    P=0.074N     P=0.098N     P=0.078N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.016N*    P=0.067N     P=0.070N     P=0.074N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.016N*    P=0.066N     P=0.067N     P=0.071N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.016N*    P=0.069N     P=0.076N     P=0.078N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.018N*    P=0.055N     P=0.055N     P=0.054N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.020N*    P=0.056N     P=0.056N     P=0.056N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    1/49 (2%)    1/50 (2%)   |5/49 (10%)   4/50 (8%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.0%         4.8%         2.4%         2.3%        |11.8%        9.9%         7.5%         0.0%         |
|TERMINAL (d)       |     4/35 (11%)   1/28 (4%)    1/34 (3%)    1/35 (3%)   |3/32 (9%)    4/30 (13%)   2/22 (9%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      587          722 (T)      722 (T)     |644          729 (T)      700          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.104N     P=0.431N     P=0.187N     P=0.178N    |P=0.036N*    P=0.546N     P=0.522N     P=0.047N*    |
|POLY 3             |     P=0.112N     P=0.365N     P=0.194N     P=0.188N    |P=0.027N*    P=0.527N     P=0.389N     P=0.038N*    |
|POLY 1.5           |     P=0.115N     P=0.356N     P=0.193N     P=0.191N    |P=0.025N*    P=0.521N     P=0.378N     P=0.036N*    |
|POLY 6             |     P=0.108N     P=0.377N     P=0.195N     P=0.183N    |P=0.029N*    P=0.536N     P=0.410N     P=0.041N*    |
|LOGISTIC REGRESSION|     P=0.114N     P=0.368N     P=0.187N     P=0.178N    |P=0.028N*    P=0.522N     P=0.391N     P=0.039N*    |
|COCH-ARM / FISHERS |     P=0.112N     P=0.339N     P=0.187N     P=0.181N    |P=0.021N*    P=0.487N     P=0.346N     P=0.027N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   7/49 (14%)   6/50 (12%)  |5/49 (10%)   2/50 (4%)    5/50 (10%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     6.6%         11.6%        15.8%        13.4%       |11.7%        4.9%         12.3%        17.3%        |
|TERMINAL (d)       |     1/35 (3%)    1/28 (4%)    2/34 (6%)    2/35 (6%)   |2/32 (6%)    2/30 (7%)    1/22 (5%)    4/29 (14%)   |
|FIRST INCIDENCE    |     574          532          514          432         |568          729 (T)      632          366          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.233      P=0.305      P=0.157      P=0.245     |P=0.139      P=0.251N     P=0.512      P=0.317      |
|POLY 3             |     P=0.201      P=0.327      P=0.146      P=0.232     |P=0.158      P=0.238N     P=0.601      P=0.337      |
|POLY 1.5           |     P=0.191      P=0.336      P=0.145      P=0.227     |P=0.162      P=0.233N     P=0.609      P=0.347      |
|POLY 6             |     P=0.216      P=0.315      P=0.150      P=0.241     |P=0.153      P=0.247N     P=0.585      P=0.326      |
|LOGISTIC REGRESSION|     P=0.231      P=0.397      P=0.169      P=0.266     |P=0.168      P=0.221N     P=0.631N     P=0.389      |
|COCH-ARM / FISHERS |     P=0.206      P=0.357      P=0.151      P=0.243     |P=0.181      P=0.210N     P=0.617N     P=0.394      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/49 (0%)    6/50 (12%)  |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.7%         0.0%         13.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    6/35 (17%)  |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     118          591          ---          722 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.021 *    P=0.478      P=0.504N     P=0.058     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.014 *    P=0.473      P=0.515N     P=0.047 *   |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.014 *    P=0.480      P=0.513N     P=0.047 *   |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.014 *    P=0.466      P=0.516N     P=0.049 *   |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.019 *    P=0.616      P=0.305N     P=0.065     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.017 *    P=0.500      P=0.505N     P=0.056     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Periportal                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/49 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         4.5%        |0.0%         4.7%         2.5%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    1/35 (3%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     520          ---          ---          59          |---          372          175          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.245      P=0.504N     P=0.513N     P=0.485     |P=0.474N     P=0.230      P=0.496      (e)          |
|POLY 3             |     P=0.251      P=0.517N     P=0.513N     P=0.492     |P=0.492N     P=0.239      P=0.495      (e)          |
|POLY 1.5           |     P=0.248      P=0.511N     P=0.511N     P=0.490     |P=0.486N     P=0.237      P=0.497      (e)          |
|POLY 6             |     P=0.257      P=0.525N     P=0.515N     P=0.495     |P=0.498N     P=0.240      P=0.489      (e)          |
|LOGISTIC REGRESSION|     P=0.349      P=0.453N     P=0.461N     P=0.674     |P=0.361N     P=0.314      P=0.664      (e)          |
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.505N     P=0.500     |P=0.457N     P=0.253      P=0.505      (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.3%         2.4%         2.3%         4.4%        |0.0%         4.7%         9.2%         7.2%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     598          8            3            9           |---          4            3            12           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.348      P=0.745      P=0.755      P=0.488     |P=0.115      P=0.237      P=0.064      P=0.122      |
|POLY 3             |     P=0.364      P=0.753      P=0.757      P=0.509     |P=0.103      P=0.236      P=0.063      P=0.113      |
|POLY 1.5           |     P=0.359      P=0.759      P=0.759      P=0.506     |P=0.108      P=0.236      P=0.064      P=0.116      |
|POLY 6             |     P=0.372      P=0.744      P=0.755      P=0.513     |P=0.100      P=0.235      P=0.059      P=0.112      |
|LOGISTIC REGRESSION|     P=0.490N     P=0.673N     P=0.680N     P=0.701N    |P=0.189      P=0.468      P=0.096      P=0.299      |
|COCH-ARM / FISHERS |     P=0.355      P=0.747N     P=0.753N     P=0.508     |P=0.113      P=0.247      P=0.059      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    4/50 (8%)    2/49 (4%)    0/50 (0%)   |4/50 (8%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         9.6%         4.7%         0.0%        |9.3%         4.9%         0.0%         2.6%         |
|TERMINAL (d)       |     0/35 (0%)    4/28 (14%)   2/34 (6%)    0/35 (0%)   |3/32 (9%)    1/30 (3%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     ---          722 (T)      722 (T)      ---         |670          599          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.317N     P=0.038 *    P=0.232      (e)         |P=0.112N     P=0.365N     P=0.110N     P=0.210N     |
|POLY 3             |     P=0.352N     P=0.054      P=0.230      (e)         |P=0.092N     P=0.359N     P=0.070N     P=0.212N     |
|POLY 1.5           |     P=0.354N     P=0.057      P=0.232      (e)         |P=0.090N     P=0.359N     P=0.068N     P=0.205N     |
|POLY 6             |     P=0.347N     P=0.050      P=0.229      (e)         |P=0.095N     P=0.360N     P=0.075N     P=0.218N     |
|LOGISTIC REGRESSION|     (e)          P=0.038 *    P=0.232      (e)         |P=0.099N     P=0.357N     P=0.076N     P=0.214N     |
|COCH-ARM / FISHERS |     P=0.333N     P=0.061      P=0.247      (e)         |P=0.086N     P=0.339N     P=0.059N     P=0.181N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    8/50 (16%)   1/49 (2%)    2/50 (4%)   |5/50 (10%)   3/50 (6%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.2%         18.7%        2.4%         4.6%        |11.3%        7.4%         2.5%         0.0%         |
|TERMINAL (d)       |     4/35 (11%)   5/28 (18%)   1/34 (3%)    2/35 (6%)   |2/32 (6%)    3/30 (10%)   0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      522          722 (T)      722 (T)     |554          729 (T)      648          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.087N     P=0.104      P=0.187N     P=0.336N    |P=0.020N*    P=0.394N     P=0.154N     P=0.048N*    |
|POLY 3             |     P=0.095N     P=0.165      P=0.187N     P=0.342N    |P=0.015N*    P=0.405N     P=0.125N     P=0.043N*    |
|POLY 1.5           |     P=0.097N     P=0.172      P=0.186N     P=0.346N    |P=0.014N*    P=0.394N     P=0.118N     P=0.040N*    |
|POLY 6             |     P=0.090N     P=0.156      P=0.188N     P=0.334N    |P=0.016N*    P=0.418N     P=0.137N     P=0.047N*    |
|LOGISTIC REGRESSION|     P=0.095N     P=0.168      P=0.187N     P=0.336N    |P=0.013N*    P=0.368N     P=0.099N     P=0.031N*    |
|COCH-ARM / FISHERS |     P=0.091N     P=0.188      P=0.181N     P=0.329N    |P=0.012N*    P=0.357N     P=0.102N     P=0.028N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    4/49 (8%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.3%         4.8%         9.5%         2.3%        |4.7%         0.0%         0.0%         5.1%         |
|TERMINAL (d)       |     1/35 (3%)    2/28 (7%)    4/34 (12%)   1/35 (3%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      722 (T)     |691          ---          ---          626          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.566N     P=0.422      P=0.170      P=0.762     |P=0.462      P=0.256N     P=0.294N     P=0.647      |
|POLY 3             |     P=0.591      P=0.483      P=0.169      P=0.758     |P=0.492      P=0.250N     P=0.255N     P=0.659      |
|POLY 1.5           |     P=0.582      P=0.491      P=0.171      P=0.756     |P=0.495      P=0.249N     P=0.250N     P=0.665      |
|POLY 6             |     P=0.587N     P=0.471      P=0.167      P=0.760N    |P=0.490      P=0.252N     P=0.263N     P=0.656      |
|LOGISTIC REGRESSION|     P=0.566N     P=0.422      P=0.170      P=0.762     |P=0.479      P=0.249N     P=0.256N     P=0.668      |
|COCH-ARM / FISHERS |     P=0.591N     P=0.508      P=0.181      P=0.747N    |P=0.500      P=0.247N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/48 (0%)    0/50 (0%)   |3/48 (6%)    0/50 (0%)    1/49 (2%)    1/47 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |7.2%         0.0%         2.5%         2.8%         |
|TERMINAL (d)       |     0/35 (0%)    0/27 (0%)    0/33 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    1/27 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |565          ---          556          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.346N     P=0.135N     P=0.353N     P=0.368N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.306N     P=0.124N     P=0.318N     P=0.358N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.305N     P=0.122N     P=0.311N     P=0.348N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.309N     P=0.128N     P=0.333N     P=0.369N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.305N     P=0.113N     P=0.288N     P=0.327N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.304N     P=0.114N     P=0.301N     P=0.316N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    0/47 (0%)    0/48 (0%)    0/50 (0%)   |0/48 (0%)    0/50 (0%)    0/49 (0%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     4.7%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/27 (0%)    0/33 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/27 (0%)    |
|FIRST INCIDENCE    |     706          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.115N     P=0.297N     P=0.249N     P=0.243N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.105N     P=0.256N     P=0.245N     P=0.236N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.107N     P=0.251N     P=0.243N     P=0.237N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.104N     P=0.263N     P=0.247N     P=0.233N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.113N     P=0.267N     P=0.247N     P=0.232N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.112N     P=0.253N     P=0.247N     P=0.237N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/48 (6%)    0/47 (0%)    1/48 (2%)    1/50 (2%)   |2/48 (4%)    2/50 (4%)    0/49 (0%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     7.0%         0.0%         2.4%         2.3%        |4.8%         4.9%         0.0%         0.0%         |
|TERMINAL (d)       |     3/35 (9%)    0/27 (0%)    1/33 (3%)    1/35 (3%)   |1/32 (3%)    2/30 (7%)    0/22 (0%)    0/27 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          722 (T)      722 (T)     |644          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.279N     P=0.170N     P=0.326N     P=0.305N    |P=0.114N     P=0.667      P=0.296N     P=0.276N     |
|POLY 3             |     P=0.277N     P=0.134N     P=0.318N     P=0.302N    |P=0.095N     P=0.687      P=0.246N     P=0.267N     |
|POLY 1.5           |     P=0.282N     P=0.130N     P=0.315N     P=0.305N    |P=0.093N     P=0.690      P=0.241N     P=0.262N     |
|POLY 6             |     P=0.270N     P=0.139N     P=0.320N     P=0.297N    |P=0.098N     P=0.682      P=0.255N     P=0.273N     |
|LOGISTIC REGRESSION|     P=0.279N     (e)          P=0.326N     P=0.305N    |P=0.098N     P=0.691      P=0.238N     P=0.256N     |
|COCH-ARM / FISHERS |     P=0.283N     P=0.125N     P=0.308N     P=0.293N    |P=0.088N     P=0.676N     P=0.242N     P=0.253N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/43 (0%)    2/47 (4%)    0/44 (0%)    0/50 (0%)   |0/48 (0%)    0/47 (0%)    1/43 (2%)    2/45 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |0.0%         0.0%         2.8%         5.5%         |
|TERMINAL (d)       |     0/33 (0%)    1/27 (4%)    0/31 (0%)    0/35 (0%)   |0/32 (0%)    0/28 (0%)    1/21 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     ---          680          ---          ---         |---          ---          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.387N     P=0.206      (e)          (e)         |P=0.069      (e)          P=0.416      P=0.216      |
|POLY 3             |     P=0.395N     P=0.244      (e)          (e)         |P=0.060      (e)          P=0.472      P=0.209      |
|POLY 1.5           |     P=0.393N     P=0.249      (e)          (e)         |P=0.062      (e)          P=0.475      P=0.213      |
|POLY 6             |     P=0.398N     P=0.237      (e)          (e)         |P=0.059      (e)          P=0.467      P=0.206      |
|LOGISTIC REGRESSION|     P=0.385N     P=0.243      (e)          (e)         |(e)          (e)          P=0.416      P=0.216      |
|COCH-ARM / FISHERS |     P=0.380N     P=0.270      (e)          (e)         |P=0.065      (e)          P=0.473      P=0.231      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/43 (5%)    3/47 (6%)    6/44 (14%)   1/50 (2%)   |1/48 (2%)    0/47 (0%)    0/43 (0%)    1/45 (2%)    |
|POLY-3 ADJUSTED (b)|     5.2%         7.5%         15.7%        2.3%        |2.4%         0.0%         0.0%         2.8%         |
|TERMINAL (d)       |     2/33 (6%)    2/27 (7%)    6/31 (19%)   1/35 (3%)   |0/32 (0%)    0/28 (0%)    0/21 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     722 (T)      561          722 (T)      722 (T)     |375          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.367N     P=0.421      P=0.111      P=0.479N    |P=0.575      P=0.513N     P=0.508N     P=0.740      |
|POLY 3             |     P=0.374N     P=0.520      P=0.128      P=0.460N    |P=0.576      P=0.521N     P=0.532N     P=0.727      |
|POLY 1.5           |     P=0.380N     P=0.527      P=0.130      P=0.462N    |P=0.579      P=0.518N     P=0.528N     P=0.733      |
|POLY 6             |     P=0.364N     P=0.508      P=0.124      P=0.458N    |P=0.574      P=0.524N     P=0.538N     P=0.723      |
|LOGISTIC REGRESSION|     P=0.361N     P=0.528      P=0.111      P=0.479N    |P=0.585      P=0.418N     P=0.509N     P=0.759N     |
|COCH-ARM / FISHERS |     P=0.356N     P=0.543      P=0.140      P=0.443N    |P=0.580      P=0.505N     P=0.527N     P=0.736      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/43 (30%)  10/47 (21%)  10/44 (23%)  12/50 (24%) |4/48 (8%)    2/47 (4%)    3/43 (7%)    2/45 (4%)    |
|POLY-3 ADJUSTED (b)|     33.1%        24.3%        25.6%        27.4%       |9.6%         5.3%         8.3%         5.5%         |
|TERMINAL (d)       |     10/33 (30%)  5/27 (19%)   6/31 (19%)   8/35 (23%)  |1/32 (3%)    1/28 (4%)    0/21 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     637          561          642          649         |568          649          692          626          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.408N     P=0.489N     P=0.376N     P=0.444N    |P=0.384N     P=0.380N     P=0.606N     P=0.403N     |
|POLY 3             |     P=0.393N     P=0.267N     P=0.316N     P=0.371N    |P=0.370N     P=0.382N     P=0.582N     P=0.400N     |
|POLY 1.5           |     P=0.402N     P=0.256N     P=0.312N     P=0.375N    |P=0.362N     P=0.376N     P=0.572N     P=0.390N     |
|POLY 6             |     P=0.378N     P=0.287N     P=0.320N     P=0.366N    |P=0.376N     P=0.389N     P=0.598N     P=0.407N     |
|LOGISTIC REGRESSION|     P=0.393N     P=0.266N     P=0.316N     P=0.367N    |P=0.361N     P=0.360N     P=0.566N     P=0.372N     |
|COCH-ARM / FISHERS |     P=0.369N     P=0.232N     P=0.291N     P=0.329N    |P=0.352N     P=0.349N     P=0.562N     P=0.370N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/43 (7%)    1/47 (2%)    1/44 (2%)    0/50 (0%)   |0/48 (0%)    0/47 (0%)    0/43 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     7.7%         2.5%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/33 (6%)    1/27 (4%)    1/31 (3%)    0/35 (0%)   |0/32 (0%)    0/28 (0%)    0/21 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     598          722 (T)      722 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.068N     P=0.374N     P=0.327N     P=0.119N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.060N     P=0.298N     P=0.311N     P=0.100N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.062N     P=0.289N     P=0.308N     P=0.100N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.058N     P=0.312N     P=0.316N     P=0.100N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.064N     P=0.283N     P=0.301N     P=0.097N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.061N     P=0.275N     P=0.299N     P=0.095N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/43 (2%)    5/47 (11%)   3/44 (7%)    4/50 (8%)   |1/48 (2%)    1/47 (2%)    0/43 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         12.3%        7.8%         9.2%        |2.4%         2.7%         0.0%         0.0%         |
|TERMINAL (d)       |     1/33 (3%)    3/27 (11%)   3/31 (10%)   3/35 (9%)   |1/32 (3%)    1/28 (4%)    0/21 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      532          722 (T)      672         |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.315      P=0.074      P=0.282      P=0.199     |P=0.262N     P=0.732      P=0.584N     P=0.520N     |
|POLY 3             |     P=0.308      P=0.113      P=0.302      P=0.215     |P=0.253N     P=0.742      P=0.528N     P=0.526N     |
|POLY 1.5           |     P=0.304      P=0.116      P=0.304      P=0.213     |P=0.251N     P=0.743      P=0.525N     P=0.522N     |
|POLY 6             |     P=0.314      P=0.107      P=0.299      P=0.218     |P=0.255N     P=0.740      P=0.533N     P=0.528N     |
|LOGISTIC REGRESSION|     P=0.316      P=0.124      P=0.282      P=0.215     |P=0.262N     P=0.732      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.327      P=0.123      P=0.317      P=0.231     |P=0.248N     P=0.747      P=0.527N     P=0.516N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/2 (50%)    0/4 (0%)     0/4 (0%)     0/2 (0%)    |3/10 (30%)   0/10 (0%)    2/7 (29%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     59.1%        0.0%         0.0%         0.0%        |36.7%        0.0%         37.5%        0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/2 (0%)     0/1 (0%)    |2/4 (50%)    0/4 (0%)     2/2 (100%)   0/5 (0%)     |
|FIRST INCIDENCE    |     542          ---          ---          ---         |644          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.313N     P=0.517N     P=0.513N     P=0.513N    |P=0.099N     P=0.115N     P=0.653      P=0.093N     |
|POLY 3             |     P=0.253N     P=0.370N     P=0.329N     P=0.482N    |P=0.166N     P=0.081N     P=0.702      P=0.147N     |
|POLY 1.5           |     P=0.261N     P=0.356N     P=0.335N     P=0.491N    |P=0.173N     P=0.085N     P=0.694N     P=0.155N     |
|POLY 6             |     P=0.241N     P=0.392N     P=0.319N     P=0.468N    |P=0.150N     P=0.079N     P=0.661      P=0.135N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.150N     P=0.088N     P=0.630      P=0.144N     |
|COCH-ARM / FISHERS |     P=0.288N     P=0.333N     P=0.333N     P=0.500N    |P=0.187N     P=0.105N     P=0.686N     P=0.176N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/4 (0%)     2/4 (50%)    1/2 (50%)   |0/10 (0%)    0/10 (0%)    1/7 (14%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         54.2%        54.5%       |0.0%         0.0%         17.5%        0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     1/2 (50%)    1/1 (100%)  |0/4 (0%)     0/4 (0%)     0/2 (0%)     0/5 (0%)     |
|FIRST INCIDENCE    |     ---          ---          657          722 (T)     |---          ---          624          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.361      (e)          P=0.500      P=1.000     |P=0.679      (e)          P=0.490      (e)          |
|POLY 3             |     P=0.261      (e)          P=0.525      P=0.599     |P=0.672      (e)          P=0.434      (e)          |
|POLY 1.5           |     P=0.197      (e)          P=0.459      P=0.551     |P=0.658      (e)          P=0.432      (e)          |
|POLY 6             |     P=0.386      (e)          P=0.628      P=0.676     |P=0.702      (e)          P=0.432      (e)          |
|LOGISTIC REGRESSION|     P=0.358      (e)          P=0.751      P=1.000     |P=0.633      (e)          P=0.408      (e)          |
|COCH-ARM / FISHERS |     P=0.143      (e)          P=0.400      P=0.500     |P=0.646      (e)          P=0.412      (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/5 (0%)     0/3 (0%)     0/0 (0%)     0/0 (0%)    |2/47 (4%)    1/50 (2%)    0/49 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |5.0%         2.5%         0.0%         0.0%         |
|TERMINAL (d)       |     0/5 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |1/31 (3%)    0/30 (0%)    0/22 (0%)    0/28 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |714          674          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.120N     P=0.517N     P=0.314N     P=0.269N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.101N     P=0.496N     P=0.244N     P=0.258N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.100N     P=0.494N     P=0.240N     P=0.252N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.103N     P=0.498N     P=0.251N     P=0.262N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.108N     P=0.496N     P=0.260N     P=0.263N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.098N     P=0.477N     P=0.237N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/7 (0%)     0/6 (0%)     0/4 (0%)    |2/17 (12%)   0/18 (0%)    0/13 (0%)    0/13 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |12.9%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/2 (0%)     0/3 (0%)     0/4 (0%)     0/1 (0%)    |1/9 (11%)    0/10 (0%)    0/7 (0%)     0/8 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |568          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.130N     P=0.231N     P=0.273N     P=0.266N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.136N     P=0.229N     P=0.305N     P=0.301N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.137N     P=0.225N     P=0.301N     P=0.299N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.135N     P=0.235N     P=0.312N     P=0.304N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.137N     P=0.201N     P=0.294N     P=0.282N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.142N     P=0.229N     P=0.313N     P=0.313N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/2 (100%)   3/7 (43%)    1/6 (17%)    2/4 (50%)   |12/17 (71%)  13/18 (72%)  11/13 (85%)  9/13 (69%)   |
|POLY-3 ADJUSTED (b)|     100.0%       56.2%        19.2%        53.4%       |73.7%        76.8%        89.6%        73.7%        |
|TERMINAL (d)       |     2/2 (100%)   2/3 (67%)    1/4 (25%)    1/1 (100%)  |7/9 (78%)    8/10 (80%)   7/7 (100%)   7/8 (88%)    |
|FIRST INCIDENCE    |     722 (T)      522          722 (T)      639         |565          555          583          526          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.577      P=0.711      P=0.215N     P=0.516     |P=0.348N     P=0.557      P=0.453      P=0.409N     |
|POLY 3             |     P=0.314N     P=0.393N     P=0.063N     P=0.419N    |P=0.540      P=0.581      P=0.270      P=0.668N     |
|POLY 1.5           |     P=0.332N     P=0.343N     P=0.056N     P=0.402N    |P=0.555      P=0.593      P=0.297      P=0.644N     |
|POLY 6             |     P=0.307N     P=0.454N     P=0.081N     P=0.458N    |P=0.498      P=0.560      P=0.226      P=0.647      |
|LOGISTIC REGRESSION|     P=0.348N     P=0.429N     P=0.215N     P=0.471N    |P=0.576      P=0.592      P=0.310      P=0.626N     |
|COCH-ARM / FISHERS |     P=0.394N     P=0.278N     P=0.107N     P=0.400N    |P=0.566      P=0.604      P=0.326      P=0.623N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  31/49 (63%)  35/49 (71%)  7/50 (14%)  |19/50 (38%)  27/50 (54%)  35/47 (74%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     32.1%        70.9%        79.0%        16.2%       |42.5%        64.6%        85.1%        87.7%        |
|TERMINAL (d)       |     10/35 (29%)  20/28 (71%)  28/34 (82%)  7/35 (20%)  |13/32 (41%)  20/30 (67%)  20/22 (91%)  27/29 (93%)  |
|FIRST INCIDENCE    |     520          522          623          722 (T)     |476          573          556          526          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009N**   P<0.001 **   P<0.001 **   P=0.052N    |P<0.001 **   P=0.057      P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.012N*    P<0.001 **   P<0.001 **   P=0.064N    |P<0.001 **   P=0.028 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.011N*    P<0.001 **   P<0.001 **   P=0.061N    |P<0.001 **   P=0.034 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.014N*    P<0.001 **   P<0.001 **   P=0.068N    |P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.011N*    P<0.001 **   P<0.001 **   P=0.053N    |P<0.001 **   P=0.042 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.010N*    P<0.001 **   P<0.001 **   P=0.045N*   |P<0.001 **   P=0.080      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     20/50 (40%)  10/49 (20%)  15/49 (31%)  2/50 (4%)   |26/50 (52%)  16/50 (32%)  12/47 (26%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     43.0%        23.8%        34.2%        4.6%        |57.2%        38.4%        30.4%        32.5%        |
|TERMINAL (d)       |     13/35 (37%)  6/28 (21%)   10/34 (29%)  1/35 (3%)   |18/32 (56%)  12/30 (40%)  7/22 (32%)   9/29 (31%)   |
|FIRST INCIDENCE    |     542          532          513          672         |476          605          632          595          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.102N     P=0.254N     P<0.001N**  |P=0.030N*    P=0.074N     P=0.071N     P=0.028N*    |
|POLY 3             |     P<0.001N**   P=0.044N*    P=0.259N     P<0.001N**  |P=0.012N*    P=0.058N     P=0.009N**   P=0.016N*    |
|POLY 1.5           |     P<0.001N**   P=0.037N*    P=0.251N     P<0.001N**  |P=0.010N*    P=0.052N     P=0.008N**   P=0.013N*    |
|POLY 6             |     P<0.001N**   P=0.056N     P=0.266N     P<0.001N**  |P=0.014N*    P=0.066N     P=0.013N*    P=0.020N*    |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.037N*    P=0.241N     P<0.001N**  |P=0.014N*    P=0.047N*    P=0.008N**   P=0.014N*    |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.028N*    P=0.222N     P<0.001N**  |P=0.008N**   P=0.034N*    P=0.007N**   P=0.007N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     20/50 (40%)  22/49 (45%)  11/49 (22%)  15/50 (30%) |12/50 (24%)  8/50 (16%)   12/47 (26%)  4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     43.1%        51.1%        26.0%        34.6%       |27.8%        19.6%        29.7%        10.4%        |
|TERMINAL (d)       |     14/35 (40%)  15/28 (54%)  11/34 (32%)  14/35 (40%) |10/32 (31%)  6/30 (20%)   6/22 (27%)   4/29 (14%)   |
|FIRST INCIDENCE    |     542          532          722 (T)      680         |644          680          556          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.057N     P=0.184      P=0.056N     P=0.208N    |P=0.082N     P=0.281N     P=0.293      P=0.043N*    |
|POLY 3             |     P=0.103N     P=0.289      P=0.069N     P=0.273N    |P=0.065N     P=0.266N     P=0.518      P=0.042N*    |
|POLY 1.5           |     P=0.101N     P=0.319      P=0.060N     P=0.265N    |P=0.059N     P=0.263N     P=0.511      P=0.038N*    |
|POLY 6             |     P=0.106N     P=0.254      P=0.081N     P=0.281N    |P=0.071N     P=0.269N     P=0.522      P=0.045N*    |
|LOGISTIC REGRESSION|     P=0.079N     P=0.312      P=0.056N     P=0.232N    |P=0.064N     P=0.269N     P=0.485      P=0.045N*    |
|COCH-ARM / FISHERS |     P=0.077N     P=0.386      P=0.047N*    P=0.201N    |P=0.043N*    P=0.227N     P=0.524      P=0.027N*    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    0/49 (0%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    0/47 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.5%         2.4%         0.0%         2.3%        |6.9%         0.0%         0.0%         2.6%         |
|TERMINAL (d)       |     1/35 (3%)    0/28 (0%)    0/34 (0%)    1/35 (3%)   |1/32 (3%)    0/30 (0%)    0/22 (0%)    1/29 (3%)    |
|FIRST INCIDENCE    |     653          645          ---          722 (T)     |644          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.355N     P=0.549N     P=0.248N     P=0.500N    |P=0.282N     P=0.139N     P=0.165N     P=0.349N     |
|POLY 3             |     P=0.365N     P=0.532N     P=0.250N     P=0.513N    |P=0.241N     P=0.131N     P=0.140N     P=0.347N     |
|POLY 1.5           |     P=0.367N     P=0.524N     P=0.248N     P=0.515N    |P=0.242N     P=0.129N     P=0.137N     P=0.338N     |
|POLY 6             |     P=0.362N     P=0.543N     P=0.252N     P=0.510N    |P=0.242N     P=0.134N     P=0.146N     P=0.356N     |
|LOGISTIC REGRESSION|     P=0.371N     P=0.508N     P=0.244N     P=0.511N    |P=0.264N     P=0.124N     P=0.134N     P=0.330N     |
|COCH-ARM / FISHERS |     P=0.366N     P=0.508N     P=0.253N     P=0.500N    |P=0.250N     P=0.121N     P=0.133N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |14/47 (30%)  9/49 (18%)   11/46 (24%)  11/49 (22%)  |
|POLY-3 ADJUSTED (b)|                                                        |34.0%        22.1%        29.1%        28.8%        |
|TERMINAL (d)       |                                                        |12/32 (38%)  7/29 (24%)   6/21 (29%)   9/29 (31%)   |
|FIRST INCIDENCE    |                                                        |565          372          509          626          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.507N     P=0.238N     P=0.478      P=0.432N     |
|POLY 3             |                                                        |P=0.452N     P=0.171N     P=0.414N     P=0.399N     |
|POLY 1.5           |                                                        |P=0.427N     P=0.168N     P=0.401N     P=0.371N     |
|POLY 6             |                                                        |P=0.472N     P=0.180N     P=0.440N     P=0.423N     |
|LOGISTIC REGRESSION|                                                        |P=0.451N     P=0.176N     P=0.428N     P=0.413N     |
|COCH-ARM / FISHERS |                                                        |P=0.348N     P=0.142N     P=0.343N     P=0.279N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |1/49 (2%)    0/49 (0%)    0/47 (0%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.4%         0.0%         0.0%         5.4%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    2/29 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |568          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.228      P=0.505N     P=0.509N     P=0.466      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.231      P=0.512N     P=0.521N     P=0.452      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.234      P=0.511N     P=0.517N     P=0.460      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.228      P=0.513N     P=0.527N     P=0.445      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.231      P=0.478N     P=0.492N     P=0.476      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.241      P=0.500N     P=0.510N     P=0.492      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    2/50 (4%)    1/48 (2%)    1/50 (2%)   |0/49 (0%)    2/49 (4%)    1/47 (2%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     6.8%         4.8%         2.4%         2.3%        |0.0%         5.0%         2.6%         5.4%         |
|TERMINAL (d)       |     1/35 (3%)    0/28 (0%)    1/34 (3%)    0/35 (0%)   |0/32 (0%)    1/30 (3%)    1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     574          638          722 (T)      709         |---          680          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.193N     P=0.558N     P=0.322N     P=0.305N    |P=0.223      P=0.224      P=0.425      P=0.216      |
|POLY 3             |     P=0.201N     P=0.526N     P=0.328N     P=0.314N    |P=0.205      P=0.228      P=0.482      P=0.210      |
|POLY 1.5           |     P=0.204N     P=0.513N     P=0.324N     P=0.315N    |P=0.211      P=0.227      P=0.484      P=0.214      |
|POLY 6             |     P=0.197N     P=0.542N     P=0.331N     P=0.312N    |P=0.200      P=0.229      P=0.476      P=0.207      |
|LOGISTIC REGRESSION|     P=0.199N     P=0.482N     P=0.310N     P=0.296N    |P=0.208      P=0.228      P=0.425      P=0.216      |
|COCH-ARM / FISHERS |     P=0.197N     P=0.490N     P=0.316N     P=0.301N    |P=0.239      P=0.247      P=0.490      P=0.242      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Duct                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/48 (2%)    1/50 (2%)   |0/49 (0%)    1/49 (2%)    2/47 (4%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         2.3%        |0.0%         2.5%         5.2%         5.4%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/34 (3%)    1/35 (3%)   |0/32 (0%)    1/30 (3%)    1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |     ---          ---          722 (T)      722 (T)     |---          729 (T)      678          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.252      (e)          P=0.494      P=0.500     |P=0.144      P=0.487      P=0.191      P=0.216      |
|POLY 3             |     P=0.237      (e)          P=0.491      P=0.498     |P=0.128      P=0.491      P=0.218      P=0.210      |
|POLY 1.5           |     P=0.232      (e)          P=0.491      P=0.496     |P=0.133      P=0.491      P=0.220      P=0.214      |
|POLY 6             |     P=0.245      (e)          P=0.491      P=0.501     |P=0.125      P=0.491      P=0.213      P=0.207      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.494      P=0.500     |P=0.131      P=0.487      P=0.217      P=0.216      |
|COCH-ARM / FISHERS |     P=0.238      (e)          P=0.495      P=0.505     |P=0.155      P=0.500      P=0.237      P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/47 (0%)    1/45 (2%)    0/49 (0%)   |5/47 (11%)   4/44 (9%)    6/42 (14%)   8/46 (17%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         0.0%        |12.3%        11.2%        16.8%        22.8%        |
|TERMINAL (d)       |     0/34 (0%)    0/26 (0%)    1/32 (3%)    0/34 (0%)   |3/31 (10%)   3/26 (12%)   3/21 (14%)   8/27 (30%)   |
|FIRST INCIDENCE    |     ---          ---          722 (T)      ---         |687          605          583          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.699      (e)          P=0.488      (e)         |P=0.111      P=0.587N     P=0.315      P=0.192      |
|POLY 3             |     P=0.694      (e)          P=0.490      (e)         |P=0.104      P=0.583N     P=0.406      P=0.182      |
|POLY 1.5           |     P=0.688      (e)          P=0.491      (e)         |P=0.115      P=0.579N     P=0.413      P=0.199      |
|POLY 6             |     P=0.703      (e)          P=0.490      (e)         |P=0.094      P=0.589N     P=0.395      P=0.168      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.488      (e)         |P=0.101      P=0.587N     P=0.398      P=0.166      |
|COCH-ARM / FISHERS |     P=0.700      (e)          P=0.495      (e)         |P=0.152      P=0.542N     P=0.420      P=0.262      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     47/50 (94%)  45/50 (90%)  47/49 (96%)  42/49 (86%) |                                                    |
|POLY-3 ADJUSTED (b)|     95.9%        93.4%        97.9%        91.3%       |                                                    |
|TERMINAL (d)       |     33/35 (94%)  26/28 (93%)  33/34 (97%)  31/35 (89%) |                                                    |
|FIRST INCIDENCE    |     520          237          226          406         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126N     P=0.195      P=0.468      P=0.239N    |                                                    |
|POLY 3             |     P=0.279N     P=0.456N     P=0.506      P=0.310N    |                                                    |
|POLY 1.5           |     P=0.302N     P=0.414N     P=0.493      P=0.314N    |                                                    |
|POLY 6             |     P=0.256N     P=0.523N     P=0.507      P=0.309N    |                                                    |
|LOGISTIC REGRESSION|     P=0.272N     P=0.478N     P=0.376      P=0.315N    |                                                    |
|COCH-ARM / FISHERS |     P=0.134N     P=0.357N     P=0.510      P=0.151N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     29/50 (58%)  25/50 (50%)  32/49 (65%)  28/49 (57%) |                                                    |
|POLY-3 ADJUSTED (b)|     61.7%        57.8%        71.1%        65.4%       |                                                    |
|TERMINAL (d)       |     22/35 (63%)  17/28 (61%)  25/34 (74%)  26/35 (74%) |                                                    |
|FIRST INCIDENCE    |     520          561          513          639         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.459N     P=0.482      P=0.293      P=0.506N    |                                                    |
|POLY 3             |     P=0.288      P=0.436N     P=0.227      P=0.440     |                                                    |
|POLY 1.5           |     P=0.294      P=0.374N     P=0.238      P=0.463     |                                                    |
|POLY 6             |     P=0.292      P=0.515N     P=0.219      P=0.424     |                                                    |
|LOGISTIC REGRESSION|     P=0.376      P=0.399N     P=0.239      P=0.537     |                                                    |
|COCH-ARM / FISHERS |     P=0.425      P=0.274N     P=0.295      P=0.547N    |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  24/50 (48%)  16/49 (33%)  18/49 (37%) |                                                    |
|POLY-3 ADJUSTED (b)|     47.7%        53.5%        37.0%        40.9%       |                                                    |
|TERMINAL (d)       |     19/35 (54%)  12/28 (43%)  13/34 (38%)  14/35 (40%) |                                                    |
|FIRST INCIDENCE    |     520          546          630          406         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.114N     P=0.173      P=0.179N     P=0.278N    |                                                    |
|POLY 3             |     P=0.180N     P=0.364      P=0.207N     P=0.332N    |                                                    |
|POLY 1.5           |     P=0.194N     P=0.373      P=0.200N     P=0.349N    |                                                    |
|POLY 6             |     P=0.156N     P=0.368      P=0.208N     P=0.300N    |                                                    |
|LOGISTIC REGRESSION|     P=0.187N     P=0.350      P=0.197N     P=0.344N    |                                                    |
|COCH-ARM / FISHERS |     P=0.164N     P=0.421      P=0.170N     P=0.298N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   3/48 (6%)    10/48 (21%)  9/49 (18%)  |                                                    |
|POLY-3 ADJUSTED (b)|     17.5%        7.6%         24.2%        21.0%       |                                                    |
|TERMINAL (d)       |     4/35 (11%)   3/27 (11%)   10/33 (30%)  7/35 (20%)  |                                                    |
|FIRST INCIDENCE    |     520          722 (T)      722 (T)      594         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.283      P=0.185N     P=0.351      P=0.497     |                                                    |
|POLY 3             |     P=0.217      P=0.151N     P=0.305      P=0.442     |                                                    |
|POLY 1.5           |     P=0.205      P=0.136N     P=0.322      P=0.438     |                                                    |
|POLY 6             |     P=0.239      P=0.173N     P=0.285      P=0.452     |                                                    |
|LOGISTIC REGRESSION|     P=0.219      P=0.127N     P=0.332      P=0.458     |                                                    |
|COCH-ARM / FISHERS |     P=0.224      P=0.113N     P=0.361      P=0.482     |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     31/48 (65%)  33/50 (66%)  26/49 (53%)  34/50 (68%) |33/50 (66%)  35/50 (70%)  36/49 (73%)  29/50 (58%)  |
|POLY-3 ADJUSTED (b)|     68.1%        72.8%        58.2%        74.7%       |72.3%        80.6%        82.8%        68.9%        |
|TERMINAL (d)       |     25/35 (71%)  22/28 (79%)  19/34 (56%)  26/35 (74%) |24/32 (75%)  26/30 (87%)  20/22 (91%)  21/29 (72%)  |
|FIRST INCIDENCE    |     520          522          514          406         |476          419          556          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.528      P=0.096      P=0.282N     P=0.351     |P=0.509N     P=0.277      P=0.020 *    P=0.514N     |
|POLY 3             |     P=0.368      P=0.391      P=0.220N     P=0.317     |P=0.342N     P=0.244      P=0.168      P=0.450N     |
|POLY 1.5           |     P=0.355      P=0.433      P=0.210N     P=0.313     |P=0.305N     P=0.262      P=0.184      P=0.412N     |
|POLY 6             |     P=0.402      P=0.341      P=0.224N     P=0.339     |P=0.374N     P=0.218      P=0.152      P=0.485N     |
|LOGISTIC REGRESSION|     P=0.385      P=0.419      P=0.202N     P=0.336     |P=0.357N     P=0.265      P=0.177      P=0.446N     |
|COCH-ARM / FISHERS |     P=0.462      P=0.526      P=0.172N     P=0.443     |P=0.192N     P=0.415      P=0.278      P=0.268N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    3/47 (6%)    0/49 (0%)   |0/49 (0%)    1/50 (2%)    1/48 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.7%         7.2%         0.0%        |0.0%         2.5%         2.6%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/34 (3%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          549          657          ---         |---          696          722          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.515N     P=0.226      P=0.118      (e)         |P=0.621N     P=0.489      P=0.451      (e)          |
|POLY 3             |     P=0.548N     P=0.230      P=0.110      (e)         |P=0.620N     P=0.493      P=0.481      (e)          |
|POLY 1.5           |     P=0.555N     P=0.234      P=0.109      (e)         |P=0.615N     P=0.494      P=0.484      (e)          |
|POLY 6             |     P=0.535N     P=0.225      P=0.113      (e)         |P=0.626N     P=0.492      P=0.475      (e)          |
|LOGISTIC REGRESSION|     P=0.528N     P=0.260      P=0.113      (e)         |P=0.613N     P=0.495      P=0.465      (e)          |
|COCH-ARM / FISHERS |     P=0.534N     P=0.253      P=0.113      (e)         |P=0.597N     P=0.505      P=0.495      (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/49 (27%)  30/50 (60%)  26/47 (55%)  23/49 (47%) |29/49 (59%)  27/50 (54%)  32/48 (67%)  39/49 (80%)  |
|POLY-3 ADJUSTED (b)|     28.1%        64.5%        61.5%        52.9%       |62.4%        63.1%        76.3%        90.2%        |
|TERMINAL (d)       |     5/35 (14%)   16/28 (57%)  22/34 (65%)  17/35 (49%) |18/32 (56%)  18/30 (60%)  19/22 (86%)  26/29 (90%)  |
|FIRST INCIDENCE    |     520          237          623          624         |375          573          417          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.224      P<0.001 **   P=0.009 **   P=0.048 *   |P=0.005 **   P=0.550N     P=0.042 *    P=0.019 *    |
|POLY 3             |     P=0.042 *    P<0.001 **   P<0.001 **   P=0.013 *   |P<0.001 **   P=0.561      P=0.115      P<0.001 **   |
|POLY 1.5           |     P=0.046 *    P<0.001 **   P<0.001 **   P=0.014 *   |P<0.001 **   P=0.562N     P=0.146      P=0.003 **   |
|POLY 6             |     P=0.040 *    P<0.001 **   P<0.001 **   P=0.012 *   |P<0.001 **   P=0.519      P=0.078      P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.091      P<0.001 **   P=0.003 **   P=0.022 *   |P=0.002 **   P=0.462N     P=0.202      P=0.008 **   |
|COCH-ARM / FISHERS |     P=0.112      P<0.001 **   P=0.004 **   P=0.029 *   |P=0.007 **   P=0.376N     P=0.290      P=0.024 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/47 (2%)    1/49 (2%)   |2/49 (4%)    5/50 (10%)   4/48 (8%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         2.4%         2.4%        |4.8%         12.4%        10.4%        5.2%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    0/34 (0%)    1/35 (3%)   |2/32 (6%)    5/30 (17%)   3/22 (14%)   2/29 (7%)    |
|FIRST INCIDENCE    |     ---          722 (T)      664          722 (T)     |729 (T)      729 (T)      642          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.404      P=0.455      P=0.489      P=0.500     |P=0.512N     P=0.188      P=0.199      P=0.660      |
|POLY 3             |     P=0.375      P=0.490      P=0.490      P=0.495     |P=0.502N     P=0.200      P=0.296      P=0.664      |
|POLY 1.5           |     P=0.369      P=0.495      P=0.489      P=0.492     |P=0.488N     P=0.203      P=0.302      P=0.671      |
|POLY 6             |     P=0.384      P=0.484      P=0.492      P=0.499     |P=0.515N     P=0.196      P=0.286      P=0.657      |
|LOGISTIC REGRESSION|     P=0.381      P=0.455      P=0.494      P=0.500     |P=0.508N     P=0.188      P=0.279      P=0.660      |
|COCH-ARM / FISHERS |     P=0.381      P=0.505      P=0.490      P=0.500     |P=0.447N     P=0.226      P=0.329      P=0.691N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    2/48 (4%)    3/49 (6%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         2.4%         4.7%         6.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/34 (3%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     706          546          226          624         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.180      P=0.731      P=0.494      P=0.313     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.168      P=0.752      P=0.491      P=0.304     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.161      P=0.756      P=0.491      P=0.297     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.180      P=0.746      P=0.492      P=0.315     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.187      P=0.744N     P=0.549      P=0.304     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.162      P=0.747N     P=0.492      P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    2/48 (4%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         4.7%         4.6%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/34 (3%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          680          226          594         |644          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.173      P=0.477      P=0.237      P=0.237     |P=0.325N     P=0.520N     P=0.531N     P=0.531N     |
|POLY 3             |     P=0.164      P=0.491      P=0.232      P=0.238     |P=0.296N     P=0.508N     P=0.515N     P=0.522N     |
|POLY 1.5           |     P=0.155      P=0.495      P=0.232      P=0.233     |P=0.298N     P=0.506N     P=0.512N     P=0.517N     |
|POLY 6             |     P=0.176      P=0.485      P=0.232      P=0.245     |P=0.295N     P=0.510N     P=0.522N     P=0.526N     |
|LOGISTIC REGRESSION|     P=0.190      P=0.501      P=0.282      P=0.255     |P=0.304N     P=0.497N     P=0.498N     P=0.499N     |
|COCH-ARM / FISHERS |     P=0.158      P=0.505      P=0.242      P=0.247     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    4/48 (8%)    1/47 (2%)   |3/48 (6%)    3/49 (6%)    4/48 (8%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     4.5%         4.7%         9.3%         2.4%        |7.0%         7.2%         9.8%         7.7%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     574          549          514          59          |64           172          417          430          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.432N     P=0.664      P=0.328      P=0.512N    |P=0.501      P=0.635      P=0.463      P=0.609      |
|POLY 3             |     P=0.444N     P=0.676      P=0.322      P=0.515N    |P=0.501      P=0.649      P=0.474      P=0.620      |
|POLY 1.5           |     P=0.455N     P=0.684      P=0.321      P=0.519N    |P=0.509      P=0.654      P=0.478      P=0.628      |
|POLY 6             |     P=0.429N     P=0.664      P=0.325      P=0.510N    |P=0.494      P=0.643      P=0.463      P=0.614      |
|LOGISTIC REGRESSION|     P=0.363N     P=0.653N     P=0.361      P=0.336N    |P=0.488N     P=0.587N     P=0.569      P=0.540N     |
|COCH-ARM / FISHERS |     P=0.454N     P=0.684N     P=0.329      P=0.516N    |P=0.565      P=0.651N     P=0.500      P=0.651N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Glands                                                                                                       |
|     Dysplasia                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    2/48 (4%)    0/47 (0%)   |0/48 (0%)    0/49 (0%)    0/48 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/35 (0%)    0/28 (0%)    1/34 (3%)    0/35 (0%)   |0/32 (0%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     ---          ---          514          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.592      (e)          P=0.232      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.592      (e)          P=0.230      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.577      (e)          P=0.229      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.612      (e)          P=0.231      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.600      (e)          P=0.246      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.585      (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/49 (2%)    1/50 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.5%         2.4%         2.3%         2.3%        |                                                    |
|TERMINAL (d)       |     2/35 (6%)    1/28 (4%)    0/34 (0%)    0/35 (0%)   |                                                    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      637          709         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.392N     P=0.578N     P=0.509N     P=0.500N    |                                                    |
|POLY 3             |     P=0.410N     P=0.525N     P=0.516N     P=0.511N    |                                                    |
|POLY 1.5           |     P=0.415N     P=0.516N     P=0.515N     P=0.514N    |                                                    |
|POLY 6             |     P=0.402N     P=0.537N     P=0.515N     P=0.505N    |                                                    |
|LOGISTIC REGRESSION|     P=0.414N     P=0.578N     P=0.514N     P=0.501N    |                                                    |
|COCH-ARM / FISHERS |     P=0.410N     P=0.500N     P=0.508N     P=0.500N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/46 (57%)  21/46 (46%)  16/39 (41%)  16/47 (34%) |11/45 (24%)  11/44 (25%)  13/46 (28%)  10/39 (26%)  |
|POLY-3 ADJUSTED (b)|     57.9%        49.0%        44.4%        38.5%       |27.2%        29.1%        32.1%        28.9%        |
|TERMINAL (d)       |     16/34 (47%)  8/27 (30%)   10/28 (36%)  12/34 (35%) |5/30 (17%)   3/28 (11%)   1/22 (5%)    3/26 (12%)   |
|FIRST INCIDENCE    |     118          237          514          624         |476          555          417          12           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.033N*    P=0.486N     P=0.136N     P=0.052N    |P=0.489      P=0.529      P=0.261      P=0.574      |
|POLY 3             |     P=0.044N*    P=0.267N     P=0.164N     P=0.055N    |P=0.475      P=0.527      P=0.406      P=0.539      |
|POLY 1.5           |     P=0.041N*    P=0.252N     P=0.159N     P=0.050N    |P=0.470      P=0.521      P=0.411      P=0.532      |
|POLY 6             |     P=0.047N*    P=0.288N     P=0.167N     P=0.060N    |P=0.475      P=0.539      P=0.389      P=0.544      |
|LOGISTIC REGRESSION|     P=0.022N*    P=0.169N     P=0.108N     P=0.029N*   |P=0.504      P=0.552      P=0.429      P=0.554N     |
|COCH-ARM / FISHERS |     P=0.021N*    P=0.202N     P=0.114N     P=0.024N*   |P=0.477      P=0.573      P=0.431      P=0.549      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Ectopic Parathyroid Gland                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/46 (0%)    0/39 (0%)    0/47 (0%)   |1/45 (2%)    0/44 (0%)    2/46 (4%)    0/39 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.6%         0.0%         5.3%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/27 (0%)    0/28 (0%)    0/34 (0%)   |1/30 (3%)    0/28 (0%)    0/22 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          659          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.493N     P=0.514N     P=0.419      P=0.529N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.516N     P=0.492      P=0.552N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.519N     P=0.515N     P=0.496      P=0.549N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.524N     P=0.516N     P=0.483      P=0.553N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.520N     (e)          P=0.490      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.494N     P=0.506N     P=0.508      P=0.536N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/46 (0%)    1/39 (3%)    1/47 (2%)   |2/45 (4%)    4/44 (9%)    3/46 (7%)    3/39 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.9%         2.4%        |5.0%         10.2%        7.6%         9.3%         |
|TERMINAL (d)       |     0/34 (0%)    0/27 (0%)    0/28 (0%)    0/34 (0%)   |0/30 (0%)    0/28 (0%)    0/22 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          514          9           |64           4            40           14           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.228      (e)          P=0.492      P=0.496     |P=0.478      P=0.328      P=0.481      P=0.479      |
|POLY 3             |     P=0.247      (e)          P=0.463      P=0.503     |P=0.380      P=0.323      P=0.490      P=0.398      |
|POLY 1.5           |     P=0.242      (e)          P=0.463      P=0.501     |P=0.386      P=0.321      P=0.496      P=0.402      |
|POLY 6             |     P=0.255      (e)          P=0.465      P=0.506     |P=0.381      P=0.326      P=0.479      P=0.401      |
|LOGISTIC REGRESSION|     P=0.401      (e)          P=0.518      (e)         |P=0.371N     P=0.756      P=0.711      P=0.544N     |
|COCH-ARM / FISHERS |     P=0.241      (e)          P=0.459      P=0.505     |P=0.429      P=0.328      P=0.511      P=0.432      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    3/50 (6%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         0.0%         0.0%        |0.0%         7.4%         0.0%         7.8%         |
|TERMINAL (d)       |     0/35 (0%)    1/28 (4%)    0/34 (0%)    0/35 (0%)   |0/32 (0%)    3/30 (10%)   0/22 (0%)    3/29 (10%)   |
|FIRST INCIDENCE    |     ---          722 (T)      ---          ---         |---          729 (T)      ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.556N     P=0.455      (e)          (e)         |P=0.142      P=0.109      (e)          P=0.103      |
|POLY 3             |     P=0.576N     P=0.490      (e)          (e)         |P=0.136      P=0.109      (e)          P=0.101      |
|POLY 1.5           |     P=0.573N     P=0.495      (e)          (e)         |P=0.141      P=0.110      (e)          P=0.104      |
|POLY 6             |     P=0.579N     P=0.484      (e)          (e)         |P=0.131      P=0.108      (e)          P=0.099      |
|LOGISTIC REGRESSION|     (e)          P=0.455      (e)          (e)         |(e)          P=0.109      (e)          P=0.103      |
|COCH-ARM / FISHERS |     P=0.565N     P=0.505      (e)          (e)         |P=0.163      P=0.121      (e)          P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         0.0%         0.0%        |9.3%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     1/35 (3%)    0/28 (0%)    0/34 (0%)    0/35 (0%)   |3/32 (9%)    0/30 (0%)    0/22 (0%)    0/29 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          ---         |711          ---          692          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.301N     P=0.545N     P=0.506N     P=0.500N    |P=0.055N     P=0.073N     P=0.283N     P=0.081N     |
|POLY 3             |     P=0.296N     P=0.510N     P=0.506N     P=0.502N    |P=0.038N*    P=0.067N     P=0.200N     P=0.074N     |
|POLY 1.5           |     P=0.297N     P=0.505N     P=0.505N     P=0.504N    |P=0.037N*    P=0.067N     P=0.196N     P=0.071N     |
|POLY 6             |     P=0.295N     P=0.516N     P=0.507N     P=0.499N    |P=0.038N*    P=0.068N     P=0.210N     P=0.076N     |
|LOGISTIC REGRESSION|     P=0.301N     (e)          (e)          (e)         |P=0.048N*    P=0.070N     P=0.218N     P=0.078N     |
|COCH-ARM / FISHERS |     P=0.304N     P=0.495N     P=0.500N     P=0.495N    |P=0.039N*    P=0.059N     P=0.181N     P=0.059N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/49 (16%)   14/50 (28%)  20/49 (41%)  12/50 (24%) |14/50 (28%)  21/50 (42%)  22/50 (44%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     18.3%        33.6%        47.0%        27.8%       |32.6%        51.5%        54.1%        59.1%        |
|TERMINAL (d)       |     8/35 (23%)   13/28 (46%)  19/34 (56%)  12/35 (34%) |13/32 (41%)  19/30 (63%)  16/22 (73%)  21/29 (72%)  |
|FIRST INCIDENCE    |     722 (T)      692          664          722 (T)     |670          674          659          680          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.306      P=0.028 *    P=0.003 **   P=0.215     |P=0.011 *    P=0.050      P=0.002 **   P=0.011 *    |
|POLY 3             |     P=0.221      P=0.083      P=0.003 **   P=0.213     |P=0.012 *    P=0.057      P=0.034 *    P=0.011 *    |
|POLY 1.5           |     P=0.207      P=0.096      P=0.004 **   P=0.209     |P=0.019 *    P=0.063      P=0.040 *    P=0.016 *    |
|POLY 6             |     P=0.247      P=0.067      P=0.003 **   P=0.223     |P=0.008 **   P=0.051      P=0.026 *    P=0.008 **   |
|LOGISTIC REGRESSION|     P=0.308      P=0.038 *    P=0.003 **   P=0.215     |P=0.008 **   P=0.048 *    P=0.015 *    P=0.007 **   |
|COCH-ARM / FISHERS |     P=0.256      P=0.124      P=0.007 **   P=0.242     |P=0.059      P=0.104      P=0.072      P=0.048 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Developmental Malformation                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/42 (100%) 10/10 (100%) 1/1 (100%)   3/3 (100%)  |2/2 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       100.0%       100.0%      |100.0%       0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     30/30 (100%) 7/7 (100%)   1/1 (100%)   3/3 (100%)  |2/2 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     520          522          722 (T)      722 (T)     |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/48 (17%)   7/49 (14%)   9/44 (20%)   8/50 (16%)  |16/45 (36%)  16/49 (33%)  17/44 (39%)  22/43 (51%)  |
|POLY-3 ADJUSTED (b)|     18.6%        17.2%        23.0%        18.5%       |40.6%        37.4%        45.7%        61.1%        |
|TERMINAL (d)       |     8/35 (23%)   6/27 (22%)   9/33 (27%)   7/35 (20%)  |14/32 (44%)  9/30 (30%)   14/22 (64%)  16/29 (55%)  |
|FIRST INCIDENCE    |     722 (T)      676          722 (T)      699         |644          555          633          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.534N     P=0.519      P=0.445      P=0.609     |P=0.044 *    P=0.505      P=0.095      P=0.078      |
|POLY 3             |     P=0.514      P=0.546N     P=0.417      P=0.602N    |P=0.024 *    P=0.470N     P=0.411      P=0.057      |
|POLY 1.5           |     P=0.497      P=0.523N     P=0.411      P=0.608N    |P=0.025 *    P=0.481N     P=0.428      P=0.056      |
|POLY 6             |     P=0.541      P=0.576N     P=0.426      P=0.591N    |P=0.025 *    P=0.458N     P=0.371      P=0.065      |
|LOGISTIC REGRESSION|     P=0.533N     P=0.582      P=0.445      P=0.592N    |P=0.017 *    P=0.523N     P=0.313      P=0.041 *    |
|COCH-ARM / FISHERS |     P=0.524      P=0.482N     P=0.421      P=0.572N    |P=0.050      P=0.468N     P=0.468      P=0.103      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/48 (6%)    3/50 (6%)    5/47 (11%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |7.3%         7.4%         13.0%        5.2%         |
|TERMINAL (d)       |                                                        |3/32 (9%)    1/30 (3%)    1/22 (5%)    2/29 (7%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      674          642          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.511N     P=0.637      P=0.209      P=0.545N     |
|POLY 3             |                                                        |P=0.488N     P=0.659      P=0.321      P=0.528N     |
|POLY 1.5           |                                                        |P=0.474N     P=0.660      P=0.327      P=0.519N     |
|POLY 6             |                                                        |P=0.500N     P=0.658      P=0.309      P=0.536N     |
|LOGISTIC REGRESSION|                                                        |P=0.489N     P=0.653      P=0.298      P=0.545N     |
|COCH-ARM / FISHERS |                                                        |P=0.428N     P=0.641N     P=0.345      P=0.480N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 04                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        125 PPM      250 PPM      500 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |44/48 (92%)  43/50 (86%)  38/47 (81%)  39/50 (78%)  |
|POLY-3 ADJUSTED (b)|                                                        |98.6%        95.5%        90.6%        86.7%        |
|TERMINAL (d)       |                                                        |32/32 (100%) 29/30 (97%)  22/22 (100%) 26/29 (90%)  |
|FIRST INCIDENCE    |                                                        |476          372          556          299          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.495N     P=0.442      P=0.181      P=0.518N     |
|POLY 3             |                                                        |P=0.009N**   P=0.387N     P=0.084N     P=0.027N*    |
|POLY 1.5           |                                                        |P=0.015N*    P=0.416N     P=0.088N     P=0.038N*    |
|POLY 6             |                                                        |P=0.006N**   P=0.407N     P=0.098N     P=0.023N*    |
|LOGISTIC REGRESSION|                                                        |P=0.091N     P=0.541N     P=0.089N     P=0.142N     |
|COCH-ARM / FISHERS |                                                        |P=0.040N*    P=0.286N     P=0.108N     P=0.054N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).