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TDMS Study 55312-04 Pathology Tables

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                                                                           TIME: 08:14:32

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  55312B

       CONTRACT NUMBER:  N01-ES-15314

       CAS NUMBER:  68603-42-9

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:14:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:    216         FIRST DOSE: 01/21/93
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:14:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 4                      ROOM/AREA:    216         FIRST DOSE: 01/21/93
            SEX: FEMALE                               TRT: 100     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:14:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 6                      ROOM/AREA:    216         FIRST DOSE: 01/21/93
            SEX: FEMALE                               TRT: 200     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

268         268  589 09/01/94   589 09/01/94   1/26  Irritation Site of Applic

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:14:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:    216         FIRST DOSE: 01/20/93
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:14:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 3                      ROOM/AREA:    216         FIRST DOSE: 01/20/93
            SEX: MALE                                 TRT: 100     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 55312-04                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 09/18/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:14:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 5                      ROOM/AREA:    216         FIRST DOSE: 01/20/93
            SEX: MALE                                 TRT: 200     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

102         102  281 10/27/93   701 12/21/94   3/26  Irritation Site of Applic

106         106  281 10/27/93   281 10/27/93   1/26  Irritation Site of Applic

109         109  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic

116         116  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic

118         118  253 09/29/93   617 09/28/94   3/23  Irritation Site of Applic

119         119  253 09/29/93   253 09/29/93   1/25  Irritation Site of Applic

120         120  253 09/29/93   253 09/29/93   1/24  Irritation Site of Applic

121         121  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic

129         129  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic

130         130  253 09/29/93   701 12/21/94   2/26  Irritation Site of Applic

131         131  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic

135         135  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic

138         138  589 08/31/94   589 08/31/94   1/26  Irritation Site of Applic

145         145  281 10/27/93   281 10/27/93   1/24  Irritation Site of Applic

148         148  253 09/29/93   589 08/31/94   2/26  Irritation Site of Applic

149         149  253 09/29/93   253 09/29/93   1/26  Irritation Site of Applic



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