TDMS Study 55323-03 Pathology Tables
NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 CORE STUDY Facility: Battelle Columbus Laboratory Chemical CAS #: 120-40-1 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 2| 6| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| DAY ON TEST | 7| 1| 2| 2| 3| 2| 4| 2| 2| 2| 1| 6| 2| 3| 2| 2| 3| 7| 2| 3| 3| 2| 3| 2| 2| | 5| 6| 9| 9| 0| 9| 0| 9| 9| 9| 9| 7| 2| 0| 9| 9| 0| 9| 7| 0| 0| 9| 0| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + A +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | A A + + + + + + + + + A + + + + + + + + + + + A +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + M M + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A A + + + + + + + + + A + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | | Hepatodiaphragmatic Nodule | X X X X X X X | Inflammation, Chronic Active | 1 1 1 1 1 1 1 | Vacuolization Cytoplasmic | | Hepatocyte, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + | Fat, Inflammation, Chronic Active | | __________________________________________________________________________| Oral Mucosa | +| Hyperplasia | 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Myocardium, Inflammation, Chronic | | Active | 1 1 2 1 2 1 1 1 1 2 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 1 | Angiectasis | 2 2 | Degeneration | 2 | Hemorrhage | 3 | Hyperplasia | | Necrosis | | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 2| 6| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| DAY ON TEST | 7| 1| 2| 2| 3| 2| 4| 2| 2| 2| 1| 6| 2| 3| 2| 2| 3| 7| 2| 3| 3| 2| 3| 2| 2| | 5| 6| 9| 9| 0| 9| 0| 9| 9| 9| 9| 7| 2| 0| 9| 9| 0| 9| 7| 0| 0| 9| 0| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + M M + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2| Hyperplasia | 2 2 1| Thrombosis | 2 | Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Cyst | 2 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 | Periovarian Tissue, Cyst | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Hydrometra | 3 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Pigmentation, Hemosiderin | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| Atrophy | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Necrosis | | Pigmentation, Hemosiderin | 3 | Thrombosis | 3 4 | __________________________________________________________________________| Thymus | + + + M + + + + + + + + M M + + + + + + M + + + +| Atrophy | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 1 1 2 1 1 2 1 2 1 1 2 2 1 1 1 2 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 2| 6| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| DAY ON TEST | 7| 1| 2| 2| 3| 2| 4| 2| 2| 2| 1| 6| 2| 3| 2| 2| 3| 7| 2| 3| 3| 2| 3| 2| 2| | 5| 6| 9| 9| 0| 9| 0| 9| 9| 9| 9| 7| 2| 0| 9| 9| 0| 9| 7| 0| 0| 9| 0| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibrosis | | Galactocele | | Hyperplasia, Cystic, Focal | | Hyperplasia, Focal | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Skin, Site of Application,| | Hyperplasia | 1 2 | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 2 | Skin, Site of Application, | | Inflammation, Chronic Active | 1 | Skin, Site of Application, | | Parakeratosis | 1 | Skin, Site of Application, Ulcer | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1| Interstitium, Fibrosis | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Mineralization | | Retina, Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Mineralization | 1 1 1 1 1 1 1 2 1 1 1 1 1 1| Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1| Pigmentation, Hemosiderin | 2 | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 2| 6| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| DAY ON TEST | 7| 1| 2| 2| 3| 2| 4| 2| 2| 2| 1| 6| 2| 3| 2| 2| 3| 7| 2| 3| 3| 2| 3| 2| 2| | 5| 6| 9| 9| 0| 9| 0| 9| 9| 9| 9| 7| 2| 0| 9| 9| 0| 9| 7| 0| 0| 9| 0| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 4| 3| | DAY ON TEST | 9| 3| 3| 6| 2| 8| 1| 2| 2| 8| 3| 2| 2| 6| 5| 0| 2| 9| 9| 6| 3| 2| 3| 7| 7| | | 4| 0| 0| 2| 9| 2| 7| 9| 9| 8| 0| 9| 9| 4| 4| 7| 9| 9| 1| 9| 0| 9| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + A + + + A + + + + + +| 45 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + A + + + A + + + + A +| 42 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + A + + + + + + + + A + + + A A + + + A +| 40 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + A + + + A + + + + A +| 42 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 | Clear Cell Focus | 3 | 1 3.0| Hepatodiaphragmatic Nodule | X X X X X| 12 | Inflammation, Chronic Active | 1 1 1 1 1 1 | 13 1.0| Vacuolization Cytoplasmic | 2 1 3 | 3 2.0| Hepatocyte, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + | 5 | Fat, Inflammation, Chronic Active | 2 2 3 3 | 4 2.5| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 | 3 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 3 | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myocardium, Inflammation, Chronic | | | Active | 2 1 1 2 1 2 2 1 2 3 2 1 1 2 1 | 27 1.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 2 1.0| Angiectasis | | 2 2.0| Degeneration | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 4| 3| | DAY ON TEST | 9| 3| 3| 6| 2| 8| 1| 2| 2| 8| 3| 2| 2| 6| 5| 0| 2| 9| 9| 6| 3| 2| 3| 7| 7| | | 4| 0| 0| 2| 9| 2| 7| 9| 9| 8| 0| 9| 9| 4| 4| 7| 9| 9| 1| 9| 0| 9| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Hemorrhage | 3 | 2 3.0| Hyperplasia | 3 | 1 3.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 1 3 2| 5 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 2 2 2 2 2 | 8 2.1| Hyperplasia | 1 | 4 1.5| Thrombosis | | 1 2.0| Pars Distalis, Angiectasis | 3 | 1 3.0| Pars Distalis, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 3 4 | 4 3.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 1 3 1 1 1 1 1 1 | 30 1.1| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 2 | 3 2.0| Periovarian Tissue, Cyst | 3 4 3 3 | 5 3.2| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Hydrometra | 2 | 4 2.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + | 3 | Pigmentation, Hemosiderin | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 4| 3| | DAY ON TEST | 9| 3| 3| 6| 2| 8| 1| 2| 2| 8| 3| 2| 2| 6| 5| 0| 2| 9| 9| 6| 3| 2| 3| 7| 7| | | 4| 0| 0| 2| 9| 2| 7| 9| 9| 8| 0| 9| 9| 4| 4| 7| 9| 9| 1| 9| 0| 9| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Congestion | | 1 2.0| Necrosis | 3 | 1 3.0| Pigmentation, Hemosiderin | | 1 3.0| Thrombosis | 3 | 3 3.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + M + + + + + + + + + +| 44 | Atrophy | 1 3 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 1 1 2 1 1 1 1 1 2 1 2 2 1 1 1 1 1 3 2 | 35 1.4| Fibrosis | 3 | 1 3.0| Galactocele | 4 | 1 4.0| Hyperplasia, Cystic, Focal | 3 | 1 3.0| Hyperplasia, Focal | 3 1 | 2 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 2 1 | 5 1.4| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 2 2 | 3 2.0| Skin, Site of Application, | | | Inflammation, Chronic Active | 3 1 | 3 1.7| Skin, Site of Application, | | | Parakeratosis | 2 | 2 1.5| Skin, Site of Application, Ulcer | 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | | 1 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 2 1.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1| 23 1.0| Interstitium, Fibrosis | 2 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 4| 3| | DAY ON TEST | 9| 3| 3| 6| 2| 8| 1| 2| 2| 8| 3| 2| 2| 6| 5| 0| 2| 9| 9| 6| 3| 2| 3| 7| 7| | | 4| 0| 0| 2| 9| 2| 7| 9| 9| 8| 0| 9| 9| 4| 4| 7| 9| 9| 1| 9| 0| 9| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 2 2 3| 4 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Lens, Mineralization | 2 | 1 2.0| Retina, Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 2 2.0| Mineralization | 1 1 1 1 1 1 1 1 1 1| 24 1.0| Nephropathy | 2 2 2 1 1 1 1 1 2 2 1 2 1 1 1 1 2 2 2 2 | 40 1.3| Pigmentation, Hemosiderin | 2 | 2 2.0| Renal Tubule, Regeneration | 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 7| 4| 7| 7| 5| 6| 7| 5| 7| 4| 7| 6| 4| 7| 7| 7| 6| 5| 7| 5| 7| DAY ON TEST | 3| 2| 8| 1| 2| 5| 2| 2| 8| 8| 3| 3| 2| 0| 3| 9| 8| 3| 3| 1| 0| 9| 2| 2| 2| | 4| 7| 2| 0| 9| 8| 8| 9| 8| 0| 0| 4| 9| 3| 0| 6| 9| 0| 0| 7| 5| 4| 9| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + A + + + + + + + + + + + + A + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + A + + + + + + + + + + + + A + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + A + A + A A + A + + + + A + + + + + + + A + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + A A + A + + + + A + + + + + + + + + + +| Mineralization | 1 | __________________________________________________________________________| Intestine Small, Ileum | + A + A + A A + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X 3 X | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X X X X X X| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | X | Necrosis | 2 2| Vacuolization Cytoplasmic | 2 1 | Bile Duct, Hyperplasia | 2 | Central Vein, Dilatation | | Hepatocyte, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + | Necrosis | | Fat, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | Acinus, Atrophy | 1 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | | Ulcer | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Myocardium, Inflammation, Chronic | | Active | 1 2 1 2 2 1 1 2 2 2 2 1 1 2 1 1 2| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 7| 4| 7| 7| 5| 6| 7| 5| 7| 4| 7| 6| 4| 7| 7| 7| 6| 5| 7| 5| 7| DAY ON TEST | 3| 2| 8| 1| 2| 5| 2| 2| 8| 8| 3| 3| 2| 0| 3| 9| 8| 3| 3| 1| 0| 9| 2| 2| 2| | 4| 7| 2| 0| 9| 8| 8| 9| 8| 0| 0| 4| 9| 3| 0| 6| 9| 0| 0| 7| 5| 4| 9| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | Hematopoietic Cell Proliferation | 1 | Hemorrhage | 3 | Hyperplasia | 2 | Hypertrophy | | Mineralization | 1 | Vacuolization Cytoplasmic | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + + + + + + + + + M + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 1 | Pars Distalis, Angiectasis | 3 | Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | | Periovarian Tissue, Cyst | 4 3 3 3 1| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + | Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 7| 4| 7| 7| 5| 6| 7| 5| 7| 4| 7| 6| 4| 7| 7| 7| 6| 5| 7| 5| 7| DAY ON TEST | 3| 2| 8| 1| 2| 5| 2| 2| 8| 8| 3| 3| 2| 0| 3| 9| 8| 3| 3| 1| 0| 9| 2| 2| 2| | 4| 7| 2| 0| 9| 8| 8| 9| 8| 0| 0| 4| 9| 3| 0| 6| 9| 0| 0| 7| 5| 4| 9| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 3 | Pigmentation, Lipofuscin | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hematopoietic Cell Proliferation | | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 1 1 1 1 2 1 2 1 2 1 2 1 1 1 1 2| Hyperplasia, Focal | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Parakeratosis | 2 | Epidermis, Skin, Site of Application,| | Hyperplasia | 1 1 2 1 1 1 1 1 1 2 1 2 1 1 2 1 2 | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 2 | Skin, Site of Application, | | Hyperkeratosis | 1 1 1 2 1 1 1 1 2 1 1 1 1 | Skin, Site of Application, | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | Skin, Site of Application, | | Parakeratosis | 1 1 1 2 2 | Skin, Site of Application, Ulcer | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 2 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Inflammation, Chronic Active | 3 | Mineralization | 1 1 1 1 1 1 1 1 1 1| Interstitium, Fibrosis | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 7| 4| 7| 7| 5| 6| 7| 5| 7| 4| 7| 6| 4| 7| 7| 7| 6| 5| 7| 5| 7| DAY ON TEST | 3| 2| 8| 1| 2| 5| 2| 2| 8| 8| 3| 3| 2| 0| 3| 9| 8| 3| 3| 1| 0| 9| 2| 2| 2| | 4| 7| 2| 0| 9| 8| 8| 9| 8| 0| 0| 4| 9| 3| 0| 6| 9| 0| 0| 7| 5| 4| 9| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Synechia | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 2 3 1 1 2 1 1 2 2 3 3 2 1 2 2 4 2 2| Pigmentation, Hemosiderin | 2 2 | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +| Inflammation, Chronic Active | 1 | Mineralization | 2 | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 3| 1| 3| 3| 2| 8| 9| 3| 2| 3| 2| 3| 2| 3| 7| 2| 2| 2| 2| 3| 4| 2| 2| 2| | | 9| 0| 8| 0| 0| 9| 2| 1| 0| 9| 0| 9| 8| 9| 0| 5| 7| 9| 9| 9| 0| 5| 9| 9| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + A + + + + + + + +| 45 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + A + + + + + + + +| 40 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + + A + + + + + + + + + + + +| 43 | Mineralization | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + + + + + +| 42 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | | 3 3.0| Eosinophilic Focus | X X | 3 | Hepatodiaphragmatic Nodule | X X X X X X X X X | 17 | Inflammation, Chronic Active | 1 1 1 1 1 | 15 1.0| Mixed Cell Focus | | 1 | Necrosis | 2 2 | 4 2.0| Vacuolization Cytoplasmic | 4 1 1 2| 6 1.8| Bile Duct, Hyperplasia | | 1 2.0| Central Vein, Dilatation | 2 | 1 2.0| Hepatocyte, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Necrosis | 2 | 1 2.0| Fat, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | | 1 2.0| Acinus, Atrophy | 1 1 | 5 1.2| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 2 1 | 2 1.5| Ulcer | 3 | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 3| 1| 3| 3| 2| 8| 9| 3| 2| 3| 2| 3| 2| 3| 7| 2| 2| 2| 2| 3| 4| 2| 2| 2| | | 9| 0| 8| 0| 0| 9| 2| 1| 0| 9| 0| 9| 8| 9| 0| 5| 7| 9| 9| 9| 0| 5| 9| 9| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Myocardium, Inflammation, Chronic | | | Active | 1 1 1 2 1 1 1 2 1 1 1 1 1 1 | 31 1.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 | 2 1.0| Hematopoietic Cell Proliferation | | 1 1.0| Hemorrhage | 2 | 2 2.5| Hyperplasia | 1 | 2 1.5| Hypertrophy | 3 | 1 3.0| Mineralization | | 1 1.0| Vacuolization Cytoplasmic | 2 1 2 | 4 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + + + M + + + M + M + M + + +| 40 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 5 1.8| Pars Distalis, Angiectasis | 2 | 2 2.5| Pars Distalis, Hyperplasia | 4 | 2 3.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1| 5 1.0| Follicle, Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 | 1 2.0| Periovarian Tissue, Cyst | 4 2 4 | 8 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 3 | 4 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 3| 1| 3| 3| 2| 8| 9| 3| 2| 3| 2| 3| 2| 3| 7| 2| 2| 2| 2| 3| 4| 2| 2| 2| | | 9| 0| 8| 0| 0| 9| 2| 1| 0| 9| 0| 9| 8| 9| 0| 5| 7| 9| 9| 9| 0| 5| 9| 9| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 2 2.5| Myelofibrosis | | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + + | 3 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 3.0| Hemorrhage | | 1 3.0| Pigmentation, Lipofuscin | 2 2 | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 2 1 2 1 1 1 1 2 2 2 1 2 2 2 1 1 2 1 1 1 2 2| 40 1.5| Hyperplasia, Focal | 1 1| 3 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parakeratosis | | 1 2.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 | 33 1.2| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 41 1.1| Skin, Site of Application, | | | Hyperkeratosis | 1 1 2 1 1 1 1| 20 1.2| Skin, Site of Application, | | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| Skin, Site of Application, | | | Parakeratosis | 1 1 1 1 1 1 1 | 12 1.2| Skin, Site of Application, Ulcer | 2 | 2 1.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 3| 1| 3| 3| 2| 8| 9| 3| 2| 3| 2| 3| 2| 3| 7| 2| 2| 2| 2| 3| 4| 2| 2| 2| | | 9| 0| 8| 0| 0| 9| 2| 1| 0| 9| 0| 9| 8| 9| 0| 5| 7| 9| 9| 9| 0| 5| 9| 9| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 2 2.5| Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Inflammation, Chronic Active | 1 | 2 2.0| Mineralization | 1 1 1 1 1 1 1 1| 18 1.0| Interstitium, Fibrosis | 1 | 2 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Synechia | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 1 1 1 1 1 1 1| 23 1.0| Nephropathy | 2 3 1 3 3 2 1 2 2 1 2 2 3 2 3 3 2 3 1 3 2 3| 41 2.1| Pigmentation, Hemosiderin | | 2 2.0| Renal Tubule, Regeneration | 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 1 | 3 1.0| Mineralization | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 3| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 7| 7| 7| 3| 7| 5| 7| 3| 7| 7| 6| 4| 7| DAY ON TEST | 3| 9| 8| 2| 2| 0| 2| 6| 2| 6| 3| 2| 3| 2| 2| 6| 3| 2| 2| 4| 2| 3| 5| 2| 2| | 4| 8| 0| 9| 9| 3| 9| 1| 2| 5| 0| 9| 0| 9| 9| 4| 0| 5| 9| 7| 4| 0| 5| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + A + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + A +| Inflammation, Chronic Active | 1 | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + A + + M + + + A + + + + + + A + A + A A + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| Ulcer | 2| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + A A + + + + + A + A + A + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + M + + + A + + + + + + A + A + A + + + A +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | | Eosinophilic Focus | | Hepatodiaphragmatic Nodule | X X X X X X X X | Inflammation, Chronic Active | 1 1 1 1 | Vacuolization Cytoplasmic | 1 | Hepatocyte, Hyperplasia | 1 | __________________________________________________________________________| Mesentery | | Fat, Inflammation, Chronic Active | | Fat, Mineralization | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | 2 | Arteriole, Thrombosis | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2| Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Heart | + + + + M + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Myocardium, Inflammation, Chronic | | Active | 1 1 3 2 1 1 1 1 2 1 1 2 2 2 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 3| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 7| 7| 7| 3| 7| 5| 7| 3| 7| 7| 6| 4| 7| DAY ON TEST | 3| 9| 8| 2| 2| 0| 2| 6| 2| 6| 3| 2| 3| 2| 2| 6| 3| 2| 2| 4| 2| 3| 5| 2| 2| | 4| 8| 0| 9| 9| 3| 9| 1| 2| 5| 0| 9| 0| 9| 9| 4| 0| 5| 9| 7| 4| 0| 5| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hemorrhage | | Hyperplasia | 1 | Necrosis | | Vacuolization Cytoplasmic | 2 3 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + M + + + + + + + + + M M + + + + + +| Hyperplasia | 2 2| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hemorrhage | | Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + M + +| Cyst | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Necrosis | 1| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 3 | Periovarian Tissue, Cyst | 3 3 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Cyst | | Hydrometra | 3 3 2 3 | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | | Pigmentation, Lipofuscin | 2 2 2 2 | Arteriole, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 3| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 7| 7| 7| 3| 7| 5| 7| 3| 7| 7| 6| 4| 7| DAY ON TEST | 3| 9| 8| 2| 2| 0| 2| 6| 2| 6| 3| 2| 3| 2| 2| 6| 3| 2| 2| 4| 2| 3| 5| 2| 2| | 4| 8| 0| 9| 9| 3| 9| 1| 2| 5| 0| 9| 0| 9| 9| 4| 0| 5| 9| 7| 4| 0| 5| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | | Congestion | | Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 2 2 2 1 1 2 2 1 1 2 1 1 2 1| Hyperplasia, Focal | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Parakeratosis | 1 | Epidermis, Skin, Site of Application,| | Hyperplasia | 2 2 1 1 1 2 1 2 1 2 1 2 2 1 1 1 2 2 2 1 3| Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 3 2 1 2 1 2 2 1 2 2 2 1 1 1 1 1 2 1 1 1 2 2 1| Skin, Site of Application, | | Hyperkeratosis | 2 2 1 1 1 2 2 1 1 1 1 1| Skin, Site of Application, | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 2| Skin, Site of Application, | | Parakeratosis | 1 2 1 1 2 1 1 1 2 3| Skin, Site of Application, Ulcer | 1 1 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 2 2 | Hemorrhage | 2 | Inflammation, Chronic Active | 1 1 1 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 3| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 7| 7| 7| 3| 7| 5| 7| 3| 7| 7| 6| 4| 7| DAY ON TEST | 3| 9| 8| 2| 2| 0| 2| 6| 2| 6| 3| 2| 3| 2| 2| 6| 3| 2| 2| 4| 2| 3| 5| 2| 2| | 4| 8| 0| 9| 9| 3| 9| 1| 2| 5| 0| 9| 0| 9| 9| 4| 0| 5| 9| 7| 4| 0| 5| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Cataract | | Lens, Mineralization | 2 2 | Posterior Chamber, Hemorrhage | | Retina, Degeneration | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 | Inflammation, Chronic Active | 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | Necrosis | | Nephropathy | 2 1 1 2 3 1 1 1 2 1 1 2 2 2 2 1 1 2 2 4| Pigmentation, Hemosiderin | 2 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + A A + + + +| Pigmentation, Hemosiderin | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 3| 5| 6| 5| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 7| 5| 0| 3| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 6| 9| 9| 0| 3| 4| 3| 3| 8| 0| 2| 0| 3| 2| 2| 9| 3| 2| 8| 2| 3| | | 9| 0| 9| 9| 3| 4| 3| 7| 0| 6| 0| 0| 8| 2| 9| 1| 5| 9| 9| 5| 6| 3| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + A + + + A + + + + + A + + + + +| 43 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A + + A + + + + + + A + A A + +| 43 | Inflammation, Chronic Active | | 1 1.0| Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + A + A A + A + + A A + + + + + A + A A A +| 31 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ulcer | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + M + + + + + + A + + A A + + + + + A + + + A +| 38 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + A + + A A + + + + + A + A + A +| 37 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X X | 2 | Hepatodiaphragmatic Nodule | X X X X | 12 | Inflammation, Chronic Active | | 4 1.0| Vacuolization Cytoplasmic | 1| 2 1.0| Hepatocyte, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + + | 4 | Fat, Inflammation, Chronic Active | 2 2 2 | 3 2.0| Fat, Mineralization | 1 1 | 2 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| Acinus, Atrophy | | 1 2.0| Arteriole, Thrombosis | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 2 2.0| Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 1 | 1 1.0| Myocardium, Inflammation, Chronic | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 3| 5| 6| 5| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 7| 5| 0| 3| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 6| 9| 9| 0| 3| 4| 3| 3| 8| 0| 2| 0| 3| 2| 2| 9| 3| 2| 8| 2| 3| | | 9| 0| 9| 9| 3| 4| 3| 7| 0| 6| 0| 0| 8| 2| 9| 1| 5| 9| 9| 5| 6| 3| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Active | 1 1 1 1 1 1 2 1 1 2 1 1 1 2 2| 35 1.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 2 | 3 1.3| Hemorrhage | 2 | 1 2.0| Hyperplasia | | 1 1.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 2 2 | 7 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 45 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Cyst | 2 2| 3 2.3| Hemorrhage | 3 | 1 3.0| Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 | 3 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Cyst | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 36 1.1| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | | 1 3.0| Periovarian Tissue, Cyst | 2 4 | 5 2.8| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Cyst | 2 | 1 2.0| Hydrometra | 3 2 1 2 | 8 2.4| __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 3| 5| 6| 5| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 7| 5| 0| 3| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 6| 9| 9| 0| 3| 4| 3| 3| 8| 0| 2| 0| 3| 2| 2| 9| 3| 2| 8| 2| 3| | | 9| 0| 9| 9| 3| 4| 3| 7| 0| 6| 0| 0| 8| 2| 9| 1| 5| 9| 9| 5| 6| 3| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 | 1 3.0| Hemorrhage | 2 | 1 2.0| Pigmentation, Lipofuscin | | 4 2.0| Arteriole, Inflammation, Chronic | | | Active | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Congestion | 2 | 1 2.0| Fibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 1 1 2 1 3 2 2 1 1 3 1 1 1 1 1 2 2 | 32 1.5| Hyperplasia, Focal | 3 4 | 2 3.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parakeratosis | | 1 1.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 2 1 2 2 1 2 2 2 1 2 2 1 2 1 2 1 2 2 2 1 1 2| 44 1.6| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 2 1 1 2 2 1 1 2 1 3 2 2 2 1 2 1 1 2 1 2 1 2| 45 1.6| Skin, Site of Application, | | | Hyperkeratosis | 1 1 1 1 1 1 1 1 2 2 2 1 1 1 1 1 2 | 29 1.3| Skin, Site of Application, | | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 1| 34 1.1| Skin, Site of Application, | | | Parakeratosis | 2 1 1 2 1 1 1 2 2 1 2 2 2 1 1 | 25 1.5| Skin, Site of Application, Ulcer | 1 1 2 2 2 2 2 | 11 1.6| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 3| 5| 6| 5| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 7| 5| 0| 3| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 6| 9| 9| 0| 3| 4| 3| 3| 8| 0| 2| 0| 3| 2| 2| 9| 3| 2| 8| 2| 3| | | 9| 0| 9| 9| 3| 4| 3| 7| 0| 6| 0| 0| 8| 2| 9| 1| 5| 9| 9| 5| 6| 3| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 3 2.3| Hemorrhage | 3 | 2 2.5| Inflammation, Chronic Active | 1 1 2| 8 1.1| Mineralization | 1 1 1 1 1 1 1 1| 19 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 2 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 6 | Cataract | 1 | 1 1.0| Lens, Mineralization | 1 | 3 1.7| Posterior Chamber, Hemorrhage | 2 | 1 2.0| Retina, Degeneration | 4 | 1 4.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 2.5| Inflammation, Chronic Active | | 2 1.0| Mineralization | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1| 27 1.1| Necrosis | 3 | 1 3.0| Nephropathy | 2 3 1 2 1 2 2 2 2 2 2 1 3 1 3 2 1 2 1 2| 41 1.8| Pigmentation, Hemosiderin | 2 | 2 2.0| Renal Tubule, Regeneration | 1 1| 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Pigmentation, Hemosiderin | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 6| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 5| DAY ON TEST | 7| 8| 0| 3| 7| 9| 0| 3| 3| 3| 2| 1| 2| 3| 2| 2| 3| 2| 6| 6| 5| 8| 0| 0| 0| | 0| 0| 9| 0| 4| 1| 3| 0| 5| 4| 9| 5| 6| 0| 9| 9| 0| 6| 5| 3| 4| 9| 2| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + A A + + A + + + + + + + + + + + + + + +| Ulcer | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + A + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic Active | 1 1 1 | Necrosis | 3 1 | Vacuolization Cytoplasmic | 3 3 2 2 2 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + + + + | Fat, Inflammation, Chronic Active | 1 1 2 2 | Fat, Mineralization | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Acinus, Atrophy | 1 1 1 2 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 2 | Hyperplasia | | Inflammation, Chronic Active | 2 1 3 2 | Mineralization | | Ulcer | 2 2 3 4 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Mineralization | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Myocardium, Inflammation, Chronic | | Active | 1 2 2 2 2 1 2 2 2 1 3 2 2 1 1 1 3 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 6| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 5| DAY ON TEST | 7| 8| 0| 3| 7| 9| 0| 3| 3| 3| 2| 1| 2| 3| 2| 2| 3| 2| 6| 6| 5| 8| 0| 0| 0| | 0| 0| 9| 0| 4| 1| 3| 0| 5| 4| 9| 5| 6| 0| 9| 9| 0| 6| 5| 3| 4| 9| 2| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Mineralization | 3 | Pigmentation, Lipofuscin | 2 | Thrombosis | 2 | Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 2 1 1 2 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 3 1 2 2 2 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | C-Cell, Hyperplasia | 1 1 | Follicle, Cyst | 2 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 2 2 3 3 2 4 4 1 1 | Inflammation, Chronic Active | 1 1 | Mineralization | 1 2 | Necrosis | | Interstitial Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | 3 | Necrosis | 3 | __________________________________________________________________________| Lymph Node | + | Angiectasis | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 6| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 5| DAY ON TEST | 7| 8| 0| 3| 7| 9| 0| 3| 3| 3| 2| 1| 2| 3| 2| 2| 3| 2| 6| 6| 5| 8| 0| 0| 0| | 0| 0| 9| 0| 4| 1| 3| 0| 5| 4| 9| 5| 6| 0| 9| 9| 0| 6| 5| 3| 4| 9| 2| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Atrophy | 2 | Ectasia | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2 2 2 3 2 3 | Fibrosis | 2| Hematopoietic Cell Proliferation | 2 | Pigmentation, Hemosiderin | 2 | Lymphoid Follicle, Depletion Cellular| | Red Pulp, Hyperplasia | 4 | __________________________________________________________________________| Thymus | + M + + + + + + M + + M + + + + + + + + + + + + M| Atrophy | 3 2 3 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 2 2 2 1 2 2 1 2 2 1 1 1 1 | Galactocele | 3 3 3 4 4 4 | Hyperplasia, Focal | 1 2 1 1 | Hyperplasia | 3 2 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperkeratosis | 2 | Parakeratosis | 3 | Subcutaneous Tissue, Fibrosis | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | Osteosclerosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 6| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 5| DAY ON TEST | 7| 8| 0| 3| 7| 9| 0| 3| 3| 3| 2| 1| 2| 3| 2| 2| 3| 2| 6| 6| 5| 8| 0| 0| 0| | 0| 0| 9| 0| 4| 1| 3| 0| 5| 4| 9| 5| 6| 0| 9| 9| 0| 6| 5| 3| 4| 9| 2| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 4 3 | Inflammation, Chronic Active | | Mineralization | | Nephropathy | 4 1 1 3 3 2 4 3 3 3 2 4 4 3 3 2 4 4 2 2 3 4 1 3 | Pigmentation, Hemosiderin | 2 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 5| 6| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 5| | DAY ON TEST | 6| 1| 0| 2| 2| 0| 6| 2| 1| 6| 4| 8| 2| 8| 1| 4| 3| 8| 1| 2| 0| 8| 4| 1| 6| | | 8| 0| 9| 9| 9| 6| 9| 4| 0| 5| 6| 4| 9| 3| 5| 5| 0| 9| 8| 9| 7| 9| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + A + + A + + + + A + + + + + + + + A A| 41 | Ulcer | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + A +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + A + + + + + + + + + + + + + + + + A +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | X X X | 5 | Inflammation, Chronic Active | 1 1 1 | 6 1.0| Necrosis | | 2 2.0| Vacuolization Cytoplasmic | 1 2 1 1 4| 11 2.1| Bile Duct, Hyperplasia | 2 2 | 7 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + +| 12 | Fat, Inflammation, Chronic Active | 2 2 2 3 2 2 3 2| 12 2.0| Fat, Mineralization | 1 2 2 2 2 | 6 1.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| Acinus, Atrophy | | 5 1.4| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | | 1 2.0| Hyperplasia | 3 | 1 3.0| Inflammation, Chronic Active | 2 2 1 3 3 3| 10 2.2| Mineralization | 2 | 1 2.0| Ulcer | 2 2 2 3 3| 11 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | | 1 2.0| Mineralization | 3 | 1 3.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 5| 6| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 5| | DAY ON TEST | 6| 1| 0| 2| 2| 0| 6| 2| 1| 6| 4| 8| 2| 8| 1| 4| 3| 8| 1| 2| 0| 8| 4| 1| 6| | | 8| 0| 9| 9| 9| 6| 9| 4| 0| 5| 6| 4| 9| 3| 5| 5| 0| 9| 8| 9| 7| 9| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Mineralization | 1 2 | 2 1.5| Myocardium, Inflammation, Chronic | | | Active | 2 2 2 2 1 2 2 1 2 2 2 1 2 2 2 1 1 2| 36 1.7| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Mineralization | | 1 3.0| Pigmentation, Lipofuscin | | 1 2.0| Thrombosis | | 1 2.0| Vacuolization Cytoplasmic | 1 2 2 1 2 2 1 | 19 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 4 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + M + + + + + M + + + + + + + + +| 47 | Hyperplasia | 2 2 3 2 2 2 1| 16 1.9| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | 1 | 1 1.0| C-Cell, Hyperplasia | 2 | 3 1.3| Follicle, Cyst | 3 | 4 2.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 50 1.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 2 2 3 3 3 | 7 2.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration | 3 1 3 1 2 1| 15 2.2| Inflammation, Chronic Active | | 2 1.0| Mineralization | 1 2 | 4 1.5| Necrosis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 5| 6| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 5| | DAY ON TEST | 6| 1| 0| 2| 2| 0| 6| 2| 1| 6| 4| 8| 2| 8| 1| 4| 3| 8| 1| 2| 0| 8| 4| 1| 6| | | 8| 0| 9| 9| 9| 6| 9| 4| 0| 5| 6| 4| 9| 3| 5| 5| 0| 9| 8| 9| 7| 9| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Hyperplasia | 2 | 3 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myelofibrosis | | 1 3.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + | 2 | Angiectasis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 2 2.0| Ectasia | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 8 2.3| Fibrosis | 1 2 | 3 1.7| Hematopoietic Cell Proliferation | | 1 2.0| Pigmentation, Hemosiderin | | 1 2.0| Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| Red Pulp, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + M + + + + + +| 44 | Atrophy | 2 2 | 7 2.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 1 1 2 1 1 1 3 2 2 2 2 1 2| 28 1.6| Galactocele | | 6 3.5| Hyperplasia, Focal | 2 | 5 1.4| Hyperplasia | 3 2 2 2 | 8 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4 | 1 4.0| Hyperkeratosis | | 1 2.0| Parakeratosis | | 1 3.0| Subcutaneous Tissue, Fibrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 2.0| Osteosclerosis | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 5| 6| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 5| | DAY ON TEST | 6| 1| 0| 2| 2| 0| 6| 2| 1| 6| 4| 8| 2| 8| 1| 4| 3| 8| 1| 2| 0| 8| 4| 1| 6| | | 8| 0| 9| 9| 9| 6| 9| 4| 0| 5| 6| 4| 9| 3| 5| 5| 0| 9| 8| 9| 7| 9| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 1 1 1 1 1 1 | 21 1.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 2 2 1 2 3 | 11 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 3 2 2 | 7 2.6| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 | 1 1.0| Nephropathy | 3 3 3 2 1 2 2 3 3 3 3 1 4 3 2 3 1 3| 42 2.7| Pigmentation, Hemosiderin | 2 | 2 2.0| Renal Tubule, Regeneration | 2 2 | 2 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 5| 7| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 6| 7| 4| 6| 6| 5| 7| DAY ON TEST | 5| 2| 2| 1| 2| 2| 8| 2| 2| 2| 6| 3| 2| 0| 9| 2| 6| 4| 7| 2| 3| 2| 8| 0| 3| | 7| 6| 5| 9| 6| 9| 5| 9| 9| 7| 2| 0| 9| 5| 6| 9| 3| 6| 4| 9| 0| 6| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X X | Hypertrophy | 1 | Inflammation, Chronic Active | 1 | Vacuolization Cytoplasmic | 3 1 1 2 1 2| Bile Duct, Hyperplasia | 2 4 | Periportal, Fibrosis | | __________________________________________________________________________| Mesentery | + + + + + + | Arteriole, Inflammation, Chronic | | Active | 1 | Fat, Inflammation, Chronic Active | 3 2 2 2 | Fat, Mineralization | 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | 1 1 1| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperkeratosis | 2 | Hyperplasia | 2 | Inflammation, Chronic Active | 1 2 | Ulcer | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | | Myocardium, Inflammation, Chronic | | Active | 2 1 1 2 1 1 3 2 2 3 2 2 2 2 2 1 1 2 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 5| 7| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 6| 7| 4| 6| 6| 5| 7| DAY ON TEST | 5| 2| 2| 1| 2| 2| 8| 2| 2| 2| 6| 3| 2| 0| 9| 2| 6| 4| 7| 2| 3| 2| 8| 0| 3| | 7| 6| 5| 9| 6| 9| 5| 9| 9| 7| 2| 0| 9| 5| 6| 9| 3| 6| 4| 9| 0| 6| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Accessory Adrenal Cortical Nodule | | Degeneration | | Vacuolization Cytoplasmic | 1 2 1 2 2 1 1 1 2 2 2 3| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + M + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 1 2 1 1 2 2 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | Congestion | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Suppurative | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Inflammation, Chronic Active | 4 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 3 3 1 2 3 2 2 3 2| Inflammation, Chronic Active | 1 | Mineralization | 1 2 1 | Interstitial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Congestion | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Congestion | 3 | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 5| 7| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 6| 7| 4| 6| 6| 5| 7| DAY ON TEST | 5| 2| 2| 1| 2| 2| 8| 2| 2| 2| 6| 3| 2| 0| 9| 2| 6| 4| 7| 2| 3| 2| 8| 0| 3| | 7| 6| 5| 9| 6| 9| 5| 9| 9| 7| 2| 0| 9| 5| 6| 9| 3| 6| 4| 9| 0| 6| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Ectasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 2 3 3 | Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 2 2 2 1 2 2 1 1 3 2 2 1 1| Galactocele | 4 3 4 3 | Hyperplasia, Focal | 1 3 1 1 2 | Hyperplasia | 2 2 2 2 | Pigmentation, Hemosiderin | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Skin, Site of Application,| | Hyperplasia | 1 1 1 1 1 1 1 2 3 1 2 1 1 1 1| Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 1 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1| Skin, Site of Application, | | Hyperkeratosis | 2 2 2 1 1 1 1 1 1 1 2 2 2 1 2| Skin, Site of Application, | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 | Skin, Site of Application, | | Parakeratosis | 1 1 2 1 1 3 1 2 1 2 1 1 2| Skin, Site of Application, Ulcer | 1 2 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Vacuolization Cytoplasmic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Interstitium, Fibrosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 5| 7| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 6| 7| 4| 6| 6| 5| 7| DAY ON TEST | 5| 2| 2| 1| 2| 2| 8| 2| 2| 2| 6| 3| 2| 0| 9| 2| 6| 4| 7| 2| 3| 2| 8| 0| 3| | 7| 6| 5| 9| 6| 9| 5| 9| 9| 7| 2| 0| 9| 5| 6| 9| 3| 6| 4| 9| 0| 6| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | | Lens, Mineralization | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Fibrosis | | Mineralization | 1 | Nephropathy | 2 4 2 2 2 4 4 1 1 4 3 2 3 3 3 2 4 1 3 2| Pigmentation, Hemosiderin | 3 | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 1| 3| 2| 3| 3| 4| 3| 2| 2| 7| 2| 8| 1| 3| 2| 8| 2| 5| 5| 8| 2| 9| 2| 1| | | 7| 3| 0| 9| 0| 4| 4| 0| 9| 9| 8| 9| 4| 4| 0| 0| 2| 6| 8| 3| 9| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A A + + A + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 2.0| Hepatodiaphragmatic Nodule | X X X X X | 8 | Hypertrophy | | 1 1.0| Inflammation, Chronic Active | 1 1 1 | 4 1.0| Vacuolization Cytoplasmic | 3 2 4 2 1 1 1 3 | 14 1.9| Bile Duct, Hyperplasia | 2 3 1 2 | 6 2.3| Periportal, Fibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + | 8 | Arteriole, Inflammation, Chronic | | | Active | | 1 1.0| Fat, Inflammation, Chronic Active | 2 2 | 6 2.2| Fat, Mineralization | 2 2 | 4 2.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| Acinus, Atrophy | 1 1 | 5 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 1 3.0| Hyperkeratosis | 2 | 2 2.0| Hyperplasia | 3 | 2 2.5| Inflammation, Chronic Active | 2 2 3 2 | 6 2.0| Ulcer | 3 3 2 2| 5 2.4| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Thrombosis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 1| 3| 2| 3| 3| 4| 3| 2| 2| 7| 2| 8| 1| 3| 2| 8| 2| 5| 5| 8| 2| 9| 2| 1| | | 7| 3| 0| 9| 0| 4| 4| 0| 9| 9| 8| 9| 4| 4| 0| 0| 2| 6| 8| 3| 9| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Myocardium, Inflammation, Chronic | | | Active | 1 2 3 2 2 1 1 2 1 1 2 3 2 2 2 2 2 2 1 2| 39 1.8| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 2 1 1 1 1 1| 7 1.1| Degeneration | 3 | 1 3.0| Vacuolization Cytoplasmic | 2 1 1 1 3 1 1 2 1 | 21 1.6| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + + + + M +| 45 | Hyperplasia | 2 3 2 2 2 3 2 | 17 1.9| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2| 1 2.0| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | + | 1 | Congestion | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 2 1 1 1 3 1 1| 46 1.1| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| Inflammation, Chronic Active | 2 3 3 | 5 2.6| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration | 3 1 3 2 2 3 3 | 16 2.4| Inflammation, Chronic Active | 1 2 2 | 4 1.5| Mineralization | 2 2 2 | 6 1.7| Interstitial Cell, Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 1| 3| 2| 3| 3| 4| 3| 2| 2| 7| 2| 8| 1| 3| 2| 8| 2| 5| 5| 8| 2| 9| 2| 1| | | 7| 3| 0| 9| 0| 4| 4| 0| 9| 9| 8| 9| 4| 4| 0| 0| 2| 6| 8| 3| 9| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Congestion | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 | 1 2.0| Congestion | | 1 3.0| Ectasia | 4 3 | 2 3.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 5 2.8| Fibrosis | 2 2 | 3 2.0| Hematopoietic Cell Proliferation | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 1 1 2 1 1 1 2 1 1 1 2 3 1 1 2 4 2 1 3 1 | 34 1.7| Galactocele | 3 2 2 | 7 3.0| Hyperplasia, Focal | 2 1 1 | 8 1.5| Hyperplasia | 2 2 2 1 1 | 9 1.8| Pigmentation, Hemosiderin | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 | 29 1.2| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1| Skin, Site of Application, | | | Hyperkeratosis | 1 1 1 1 2 2 1 1 | 23 1.4| Skin, Site of Application, | | | Inflammation, Chronic Active | 1 1 2 | 10 1.1| Skin, Site of Application, | | | Parakeratosis | 1 1 2 1 1 1 1 1 | 21 1.3| Skin, Site of Application, Ulcer | 1 | 4 1.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 1| 3| 2| 3| 3| 4| 3| 2| 2| 7| 2| 8| 1| 3| 2| 8| 2| 5| 5| 8| 2| 9| 2| 1| | | 7| 3| 0| 9| 0| 4| 4| 0| 9| 9| 8| 9| 4| 4| 0| 0| 2| 6| 8| 3| 9| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vacuolization Cytoplasmic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Inflammation, Chronic Active | 1 | 3 1.0| Mineralization | 1 1 1 1 1 1 1 1 | 22 1.0| Interstitium, Fibrosis | 2 3 | 2 2.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 5 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Lens, Mineralization | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 1 2 | 4 2.0| Fibrosis | 3 | 1 3.0| Mineralization | | 1 1.0| Nephropathy | 4 4 3 3 2 3 2 3 4 3 4 2 2 1 3 2 3 4 1 2 | 40 2.7| Pigmentation, Hemosiderin | 1 | 2 2.0| Renal Tubule, Regeneration | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 1| 5| 6| 6| 2| 7| DAY ON TEST | 5| 8| 1| 7| 0| 1| 3| 4| 5| 3| 2| 2| 2| 9| 3| 9| 2| 2| 8| 0| 8| 3| 4| 6| 0| | 7| 3| 9| 0| 6| 9| 0| 5| 4| 0| 9| 9| 9| 6| 0| 5| 7| 9| 4| 6| 9| 2| 2| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + A A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + + + + A + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + + + + A + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A A + + + + + + + +| Inflammation, Chronic | 1 | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + + + + A + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic Active | 1 1 | Necrosis | 1 | Vacuolization Cytoplasmic | 1 1 1 1 2 1 2 1| Bile Duct, Hyperplasia | 3 2 | __________________________________________________________________________| Mesentery | + + | Fat, Inflammation, Chronic Active | | Fat, Mineralization | | Fat, Necrosis | | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 2 1 1 1 | Arteriole, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2| Hyperkeratosis | 2| Inflammation, Chronic Active | 1 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Thrombosis | 2 | Myocardium, Inflammation, Chronic | | Active | 2 2 3 2 2 1 1 3 2 2 2 2 2 3 2 2 1 1 1 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 1| 5| 6| 6| 2| 7| DAY ON TEST | 5| 8| 1| 7| 0| 1| 3| 4| 5| 3| 2| 2| 2| 9| 3| 9| 2| 2| 8| 0| 8| 3| 4| 6| 0| | 7| 3| 9| 0| 6| 9| 0| 5| 4| 0| 9| 9| 9| 6| 0| 5| 7| 9| 4| 6| 9| 2| 2| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 2 | Degeneration | | Hyperplasia | 2 1 | Vacuolization Cytoplasmic | 1 2 1 1 1 2 2 1 1 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Mineralization | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 2 2 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Mineralization | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | | Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Suppurative | | __________________________________________________________________________| Prostate | + A + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Fibrosis | | Inflammation, Chronic Active | 3 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + A + + + + + + + + +| Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 3 2 1 2 2 2 2| Inflammation, Chronic Active | 1 | Mineralization | 1 1 1 1 | Interstitial Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 1| 5| 6| 6| 2| 7| DAY ON TEST | 5| 8| 1| 7| 0| 1| 3| 4| 5| 3| 2| 2| 2| 9| 3| 9| 2| 2| 8| 0| 8| 3| 4| 6| 0| | 7| 3| 9| 0| 6| 9| 0| 5| 4| 0| 9| 9| 9| 6| 0| 5| 7| 9| 4| 6| 9| 2| 2| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Ectasia | | Necrosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2 2 | Fibrosis | 1 2 2 | Hematopoietic Cell Proliferation | | Hemorrhage | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 1 1 1 1 2 1 1 3 1 1 2 2 2 2 2| Galactocele | 1 3 2 4 | Hyperplasia, Cystic, Focal | | Hyperplasia, Focal | 1 2 2 3 | Hyperplasia | 1 1| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Pinna, Hyperplasia | | Epidermis, Skin, Site of Application,| | Hyperplasia | 2 1 2 2 1 2 2 1 2 2 1 1 2 2 2 1 1 2 1 1 2 2 2 2| Pinna, Parakeratosis | | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 1 2 2 1 2 2 2 2 2 1 2 2 1 2 1 1 2 2 1 2 1 2 2| Skin, Site of Application, Edema | | Skin, Site of Application, | | Hyperkeratosis | 1 1 1 1 1 1 1 2 1 1 1 1| Skin, Site of Application, | | Inflammation, Chronic Active | 3 1 2 1 1 1 1 1 1 3 2 1 1 1 1 1 2| Skin, Site of Application, | | Parakeratosis | 1 2 3 2 3 1 2 2 2 2 2 2 1 1 2 3 2 3| Skin, Site of Application, Ulcer | 3 2 2 2 1 2 3 2 1 1 1 3 2 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 | __________________________________________________________________________| Skeletal Muscle | + | Hemorrhage | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 3 | Mineralization | 2 | Vacuolization Cytoplasmic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 1| 5| 6| 6| 2| 7| DAY ON TEST | 5| 8| 1| 7| 0| 1| 3| 4| 5| 3| 2| 2| 2| 9| 3| 9| 2| 2| 8| 0| 8| 3| 4| 6| 0| | 7| 3| 9| 0| 6| 9| 0| 5| 4| 0| 9| 9| 9| 6| 0| 5| 7| 9| 4| 6| 9| 2| 2| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | 2 1| Mineralization | 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Inflammation, Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Mineralization | | Lens, Mineralization | 2 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 2 | Mineralization | 1 | Nephropathy | 2 3 4 4 1 3 2 1 3 2 2 3 2 2 3 3 2 2 1 3 3| Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Necrosis | 2 | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 7| 5| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 1| 8| 2| 8| 5| 2| 0| 2| 8| 8| 3| 3| 1| 2| 8| 5| 2| 0| 0| 2| 2| 3| | | 9| 3| 9| 7| 9| 9| 3| 5| 2| 3| 7| 9| 3| 0| 0| 3| 6| 9| 8| 9| 3| 3| 9| 9| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 | Parasite Metazoan | X X X| 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + A + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + A + + + + + + + +| 46 | Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + A + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatodiaphragmatic Nodule | X X X X | 6 | Inflammation, Chronic Active | 1 | 3 1.0| Necrosis | 1 | 2 1.0| Vacuolization Cytoplasmic | 1 3 2 1 3 1 1 | 15 1.5| Bile Duct, Hyperplasia | 1 1 3 2 | 6 2.0| __________________________________________________________________________|____________| Mesentery | + + + +| 6 | Fat, Inflammation, Chronic Active | 1 2 | 2 1.5| Fat, Mineralization | 1 | 1 1.0| Fat, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 1 1 2 | 11 1.4| Arteriole, Inflammation, Chronic | | | Active | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 2 2.0| Hyperkeratosis | | 1 2.0| Inflammation, Chronic Active | 3 3 2 2 1 2| 7 2.0| Ulcer | 3 3 3 | 3 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 3 | 3 2.7| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 2 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 7| 5| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 1| 8| 2| 8| 5| 2| 0| 2| 8| 8| 3| 3| 1| 2| 8| 5| 2| 0| 0| 2| 2| 3| | | 9| 3| 9| 7| 9| 9| 3| 5| 2| 3| 7| 9| 3| 0| 0| 3| 6| 9| 8| 9| 3| 3| 9| 9| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Thrombosis | | 1 2.0| Myocardium, Inflammation, Chronic | | | Active | 2 2 2 2 2 1 1 2 1 2 2 3 2 1 2 1 2 2 2 2 2 | 41 1.9| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 2 1 2 | 6 1.5| Degeneration | 2 | 1 2.0| Hyperplasia | 2 | 3 1.7| Vacuolization Cytoplasmic | 2 2 2 2 1 1 1 1 1 2 2| 22 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M M + + + + + + + + + + M + + + + + +| 47 | Hyperplasia | 3 2 2 2 2 2 2 | 13 2.1| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 2 1 | 3 1.7| Follicle, Cyst | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| Inflammation, Suppurative | 3 | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 2.0| Fibrosis | 2 | 1 2.0| Inflammation, Chronic Active | | 3 1.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 2 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 7| 5| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 1| 8| 2| 8| 5| 2| 0| 2| 8| 8| 3| 3| 1| 2| 8| 5| 2| 0| 0| 2| 2| 3| | | 9| 3| 9| 7| 9| 9| 3| 5| 2| 3| 7| 9| 3| 0| 0| 3| 6| 9| 8| 9| 3| 3| 9| 9| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Degeneration | 2 3 2 3 1 3 2 2 3 2| 17 2.2| Inflammation, Chronic Active | 1 2 2 1 | 5 1.4| Mineralization | 1 2 2| 7 1.3| Interstitial Cell, Hyperplasia | 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Ectasia | 3 | 1 3.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 2| 5 2.2| Fibrosis | | 3 1.7| Hematopoietic Cell Proliferation | 3 | 1 3.0| Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Dilatation | 1 3 3 3 2 2 2 3 2 2 1 3 2 2 2| 31 1.9| Galactocele | 1 1 1 3 3 | 9 2.1| Hyperplasia, Cystic, Focal | 3 | 1 3.0| Hyperplasia, Focal | 2 | 5 2.0| Hyperplasia | 1 1 2 | 5 1.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Pinna, Hyperplasia | 3 | 1 3.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 2 1 1 2 2 2 2 2 1 2 2 3 1 1 2 2 2 3 1| 44 1.7| Pinna, Parakeratosis | 1 | 1 1.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 3 2 2 1 3 3 2 2 1 1 2 1 1 1 2 2 1 1 1 2 1| 44 1.7| Skin, Site of Application, Edema | 2 | 1 2.0| Skin, Site of Application, | | | Hyperkeratosis | 1 1 1 1 1 1 2 1 1 2 2 2 1| 25 1.2| Skin, Site of Application, | | | Inflammation, Chronic Active | 2 2 2 2 1 3 2 1 1 1 1| 28 1.5| Skin, Site of Application, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 7| 5| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 1| 8| 2| 8| 5| 2| 0| 2| 8| 8| 3| 3| 1| 2| 8| 5| 2| 0| 0| 2| 2| 3| | | 9| 3| 9| 7| 9| 9| 3| 5| 2| 3| 7| 9| 3| 0| 0| 3| 6| 9| 8| 9| 3| 3| 9| 9| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Parakeratosis | 1 2 3 1 2 2 1 1 1 2 1 3 2 2 2| 33 1.9| Skin, Site of Application, Ulcer | 2 2 2 2 3 2 1 1 1 2 2| 25 1.9| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | | 1 3.0| Mineralization | | 1 2.0| Vacuolization Cytoplasmic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 2 1 | 4 1.5| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.1| Alveolar Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| Inflammation, Suppurative | 2 2 | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | Mineralization | 2 | 1 2.0| Lens, Mineralization | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 4 2 | 6 2.5| Mineralization | 2 1 | 3 1.3| Nephropathy | 3 4 3 3 2 2 2 4 2 2 2 3 2 2 2 1 1 4 1| 40 2.4| Renal Tubule, Regeneration | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 55323-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:30:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 7| 5| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 1| 8| 2| 8| 5| 2| 0| 2| 8| 8| 3| 3| 1| 2| 8| 5| 2| 0| 0| 2| 2| 3| | | 9| 3| 9| 7| 9| 9| 3| 5| 2| 3| 7| 9| 3| 0| 0| 3| 6| 9| 8| 9| 3| 3| 9| 9| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Hemorrhage | | 1 3.0| Necrosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------