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TDMS Study 56111-03 Pathology Tables

NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01
Route: DOSED FEED                                                                                                 Time: 10:35:47

                                                            FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  14371-10-9

       Lock Date:  06/01/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           10           13           10           10                        
    Natural Death                                      5            4            4            4            7                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           36           33           35           33                        
    Natural Death                                      1                                                                            
  Missing                                                                                     1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           49           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)         (50)                      
      Lipoma                                                                                               1 (2%)                   
   Intestine Large, Colon                             (50)         (50)         (50)         (49)         (50)                      
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)         (50)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)         (50)                      
      Carcinoma                                                                  1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)         (49)         (50)                      
   Liver                                              (50)         (50)         (50)         (49)         (50)                      
      Cholangiocarcinoma                                                         1 (2%)                                             
   Mesentery                                          (11)         (9)          (6)          (9)          (8)                       
   Pancreas                                           (50)         (50)         (50)         (49)         (50)                      
   Salivary Glands                                    (50)         (50)         (49)         (49)         (50)                      
   Stomach, Forestomach                               (50)         (50)         (50)         (49)         (50)                      
   Stomach, Glandular                                 (50)         (50)         (50)         (49)         (50)                      
   Tongue                                                                       (1)          (1)                                    
      Squamous Cell Papilloma                                                    1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)         (50)                      
      Hemangiosarcoma                                                                                      1 (2%)                   
      Schwannoma Malignant                                                                                 1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Lung        1 (2%)                                                                       
      Thymoma Malignant, Metastatic, Thymus            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)         (50)                      
      Adenoma                                          1 (2%)                                                                       
      Chondrosarcoma, Metastatic, Bone                                           1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (49)         (50)                      
      Chondrosarcoma, Metastatic, Bone                                           1 (2%)                                             
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)                                                          
      Pheochromocytoma Complex                                      1 (2%)                    1 (2%)                                
      Pheochromocytoma Benign                                                    2 (4%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)         (50)                      
      Adenoma                                                                    1 (2%)                    2 (4%)                   
      Carcinoma                                        2 (4%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (49)         (50)                      
      Pars Distalis, Adenoma                          19 (38%)     16 (32%)     17 (34%)     15 (31%)     17 (34%)                  
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (49)         (50)                      
      C-Cell, Adenoma                                  5 (10%)      6 (12%)      3 (6%)       4 (8%)       5 (10%)                  
      C-Cell, Carcinoma                                3 (6%)                                 3 (6%)                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (49)         (50)                      
      Adenoma                                          3 (6%)                    4 (8%)       1 (2%)       2 (4%)                   
      Carcinoma                                        3 (6%)       6 (12%)      1 (2%)       2 (4%)       2 (4%)                   
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (49)         (50)                      
      Cystadenoma                                                   1 (2%)                                                          
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (49)         (50)                      
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                    6 (12%)      7 (14%)      5 (10%)      8 (16%)     12 (24%)                  
      Polyp Stromal, Multiple                                                    3 (6%)                                             
      Bilateral, Polyp Stromal                         1 (2%)                                                                       
      Endometrium, Carcinoma                                                     1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)         (50)                      
   Lymph Node                                         (30)         (25)         (26)         (24)         (27)                      
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (3%)                                                                       
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                        2 (7%)                                                                       
   Lymph Node, Mandibular                             (1)          (2)                       (1)          (2)                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)         (50)                      
   Spleen                                             (50)         (50)         (49)         (49)         (50)                      
   Thymus                                             (43)         (49)         (47)         (48)         (47)                      
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)         (50)                      
      Adenolipoma                                                                             1 (2%)                                
      Adenoma, Multiple                                             1 (2%)                                                          
      Carcinoma                                        1 (2%)                                 3 (6%)                                
      Fibroadenoma                                    17 (34%)     22 (44%)     18 (36%)     16 (33%)     16 (32%)                  
      Fibroadenoma, Multiple                           8 (16%)      8 (16%)      9 (18%)      5 (10%)      5 (10%)                  
   Skin                                               (50)         (50)         (50)         (49)         (50)                      
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                                            2 (4%)                    1 (2%)                   
      Neural Crest Tumor                               1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)         (50)                      
      Chondrosarcoma                                                             1 (2%)                                             
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                                 (1)          (1)                       (1)                       
      Chondrosarcoma, Metastatic, Bone                                           1 (100%)                                           
      Lipoma                                                        1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)         (50)                      
      Astrocytoma Malignant                            1 (2%)                                                                       
   Spinal Cord                                                                               (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)         (50)                      
      Alveolar/Bronchiolar Adenoma                     2 (4%)       4 (8%)       2 (4%)       2 (4%)       2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Chondrosarcoma, Metastatic, Bone                                           1 (2%)                                             
      Pheochromocytoma Complex, Metastatic,                                                                                         
          Adrenal Medulla                                                                     1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Lung        1 (2%)                                                                       
      Thymoma Malignant, Metastatic, Thymus            1 (2%)                                                                       
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                             1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (49)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (2)                                                 
      Adenoma                                          1 (100%)                                                                     
      Carcinoma                                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)         (50)                      
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (49)         (50)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)        *(50)                      
      Adenolipoma                                                                             1 (2%)                                
      Leukemia Mononuclear                             9 (18%)     12 (24%)      8 (16%)      7 (14%)      9 (18%)                  
      Lymphoma Malignant                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          47          42          44          42                           
     Total Primary Neoplasms                           89          90          87          71          76                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          39          37          38          38                           
     Total Benign Neoplasms                            64          69          71          54          63                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          18          14          16          13                           
     Total Malignant Neoplasms                         24          21          16          17          13                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6                       1           1                                       
     Total Metastatic Neoplasm                         10                       4           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           13           11           11            6                        
    Natural Death                                      7            6            3           12            3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           31           36           27           41                        
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (50)                      
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma                                                                                       1 (2%)                   
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Cholangiocarcinoma                               1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Skin                                     2 (4%)       1 (2%)       1 (2%)                   
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
   Mesentery                                          (14)         (5)          (8)          (9)          (12)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (13%)                                            
      Lipoma                                                        1 (20%)                                1 (8%)                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (20%)                                                         
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (13%)                                            
   Oral Mucosa                                        (13)         (13)         (14)         (12)         (24)                      
      Gingival, Squamous Cell Carcinoma                             1 (8%)                    1 (8%)                                
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Mixed Tumor Benign                                            1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
      Acinus, Adenoma                                  1 (2%)                    1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (50)         (50)         (50)         (50)         (50)                      
      Carcinoma                                                                                            1 (2%)                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (50)                      
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
   Tongue                                             (1)                                    (1)                                    
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Schwannoma Malignant                                          2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Ganglioneuroma                                   1 (2%)                                                                       
      Pheochromocytoma Benign                          5 (10%)                   3 (6%)       4 (8%)                                
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)       1 (2%)                    1 (2%)                                
      Carcinoma                                                                                            1 (2%)                   
   Parathyroid Gland                                  (47)         (45)         (48)         (46)         (42)                      
      Adenoma                                                                    2 (4%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Salivary Glands                                                               1 (2%)                   
      Pars Distalis, Adenoma                          13 (26%)      8 (16%)     10 (20%)     10 (20%)      8 (16%)                  
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)                                             
      Bilateral, C-Cell, Carcinoma                                                                         1 (2%)                   
      C-Cell, Adenoma                                  4 (8%)       7 (14%)      9 (18%)      3 (6%)      10 (20%)                  
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)          (1)                       (1)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
   Preputial Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Adenoma                                          2 (4%)       5 (10%)      1 (2%)       2 (4%)                                
      Carcinoma                                        3 (6%)       1 (2%)       2 (4%)       3 (6%)       1 (2%)                   
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
   Prostate                                           (50)         (50)         (49)         (49)         (50)                      
      Adenoma                                                       4 (8%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (49)         (50)                      
   Testes                                             (50)         (50)         (49)         (50)         (50)                      
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     39 (78%)     44 (90%)     35 (70%)     47 (94%)                  
      Interstitial Cell, Adenoma                      11 (22%)      7 (14%)      3 (6%)       7 (14%)      3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
   Lymph Node                                         (24)         (20)         (28)         (28)         (20)                      
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                                       1 (4%)       1 (5%)                   
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                                                            1 (5%)                   
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skin                                                       1 (4%)                                             
      Pancreatic, Fibrous Histiocytoma, Metastatic,                                                                                 
           Skin                                                                  1 (4%)                                             
   Lymph Node, Mandibular                             (2)                       (4)                                                 
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (43)         (44)         (45)         (46)         (43)                      
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Fibroadenoma                                     2 (4%)       1 (2%)       2 (4%)       2 (4%)       1 (2%)                   
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                             1 (2%)                    1 (2%)                                             
      Keratoacanthoma                                  2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
      Keratoacanthoma, Multiple                        1 (2%)                    1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Trichoepithelioma                                             1 (2%)       3 (6%)                                             
      Sebaceous Gland, Adenoma                                                                1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)       5 (10%)                   2 (4%)       4 (8%)                   
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                4 (8%)       2 (4%)       1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma                                  2 (4%)       1 (2%)       1 (2%)                   
      Subcutaneous Tissue, Sarcoma                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma                                                                            1 (2%)                                
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
   Skeletal Muscle                                    (2)          (1)          (3)          (1)          (1)                       
      Fibrous Histiocytoma, Metastatic, Skin                                     2 (67%)                   1 (100%)                 
      Rhabdomyosarcoma                                                           1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)       6 (12%)      6 (12%)      1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    2 (4%)       1 (2%)                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Salivary Glands                                                               1 (2%)                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)       1 (2%)       1 (2%)                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                    1 (2%)                                                          
      Mediastinum, Fibrosarcoma, Metastatic, Skin      1 (2%)                                                                       
      Mediastinum, Osteosarcoma, Metastatic,                                                                                        
          Uncertain Primary Site                                    1 (2%)                                                          
      Mediastinum, Rhabdomyosarcoma, Metastatic,                                                                                    
           Skeletal Muscle                                                       1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Fibroma                                                                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                    1 (2%)                                                          
   Trachea                                            (50)         (50)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)                       (2)                       
      Adenoma                                                                                              1 (50%)                  
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)       1 (2%)                                
      Renal Tubule, Adenoma, Multiple                                                         1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (49)         (50)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Leukemia Mononuclear                            22 (44%)     18 (36%)     15 (30%)     21 (42%)      9 (18%)                  
      Mesothelioma Malignant                           3 (6%)       2 (4%)       5 (10%)                   1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01  
Route: DOSED FEED                                                                                                 Time: 10:35:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          49          48          50                           
     Total Primary Neoplasms                          119         121         122         112          95                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          49          48          48          50                           
     Total Benign Neoplasms                            83          90          90          80          76                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          27          27          27          19                           
     Total Malignant Neoplasms                         36          31          32          32          19                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           4           4           3                           
     Total Metastatic Neoplasm                          4           9          26           9           7                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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