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TDMS Study 56111-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 06/14/01       
EXPERIMENT: 56111 TEST: 04                                                                                     TIME: 09:30:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: MARIT, GARY                                                                                       CAS: 14371-10-9      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            Final#1/Mice                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 003    VEHICLE CONTROL                                                               
                                       INCLUDE 004    VEHICLE CONTROL                                                               
                                       INCLUDE 005    .312%                                                                         
                                       INCLUDE 006    .312%                                                                         
                                       INCLUDE 007    .625%                                                                         
                                       INCLUDE 008    .625%                                                                         
                                       INCLUDE 009    1.25%                                                                         
                                       INCLUDE 010    1.25%                                                                         
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 06/14/01       
EXPERIMENT: 56111 TEST: 04                                                                                     TIME: 09:30:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: MARIT, GARY                                                                                       CAS: 14371-10-9      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF               TRANS-CINNAMALDEHYDE                                                                               
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Heart                                  Mineralization                                                                               
Kidney                                 Infarct                                                                                      
                                       Infiltration Cellular Lymphocyte                                                             
                                       Mineralization                                                                               
                                       Nephropathy                                                                                  
Liver                                  Inflammation                                                                                 
Liver: Portal                          Infiltration Cellular Lymphocyte                                                             
Nose: Olfactory Epithelium             Pigmentation                                                                                 
Preputial Gland                        Inflammation                                                                                 
Preputial Gland: Duct                  Ectasia                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone                                   Myelofibrosis                                                                                
Kidney                                 Infiltration Cellular Lymphocyte                                                             
                                       Nephropathy                                                                                  
Liver                                  Clear Cell Focus                                                                             
Mesentery: Fat                         Mineralization                                                                               
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Ulcer                                                                                        
Thyroid Gland: Follicle                Cyst                                                                                         
Urinary Bladder                        Inflammation                                                                                 
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE   
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |2/50 (4%)    6/50 (12%)   2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      1/44.02      0/49.55     |2/46.06      6/45.42      2/47.80      2/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.3%         13.2%        4.2%         4.3%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    1/39 (3%)    0/49 (0%)   |2/41 (5%)    6/37 (16%)   2/44 (5%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          728 (T)      ---         |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.693      (e)          P=0.463      (e)         |P=0.301N     P=0.103      P=0.669N     P=0.678N     | 
|POLY 3             |     P=0.708      (e)          P=0.481      (e)         |P=0.334N     P=0.128      P=0.680N     P=0.690N     | 
|POLY 1.5           |     P=0.705      (e)          P=0.488      (e)         |P=0.340N     P=0.131      P=0.685N     P=0.693N     | 
|POLY 6             |     P=0.711      (e)          P=0.473      (e)         |P=0.328N     P=0.123      P=0.676N     P=0.686N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.463      (e)         |P=0.301N     P=0.103      P=0.669N     P=0.678N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.495      (e)         |P=0.343N     P=0.134      P=0.691N     P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  22/50 (44%)  24/49 (49%)  19/50 (38%) |4/50 (8%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     23/48.41     22/48.44     24/44.12     19/49.55    |4/46.06      2/45.42      2/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     47.5%        45.4%        54.4%        38.4%       |8.7%         4.4%         4.2%         2.2%         | 
|TERMINAL (d)       |     23/47 (49%)  21/46 (46%)  23/39 (59%)  19/49 (39%) |4/41 (10%)   2/37 (5%)    2/44 (5%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      644          702          728 (T)     |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207N     P=0.538N     P=0.178      P=0.214N    |P=0.117N     P=0.385N     P=0.305N     P=0.166N     | 
|POLY 3             |     P=0.222N     P=0.499N     P=0.325      P=0.239N    |P=0.132N     P=0.344N     P=0.320N     P=0.176N     | 
|POLY 1.5           |     P=0.223N     P=0.500N     P=0.389      P=0.242N    |P=0.135N     P=0.341N     P=0.327N     P=0.179N     | 
|POLY 6             |     P=0.221N     P=0.500N     P=0.258      P=0.236N    |P=0.128N     P=0.351N     P=0.314N     P=0.172N     | 
|LOGISTIC REGRESSION|     P=0.226N     P=0.516N     P=0.182      P=0.214N    |P=0.117N     P=0.385N     P=0.305N     P=0.166N     | 
|COCH-ARM / FISHERS |     P=0.254N     P=0.500N     P=0.462      P=0.272N    |P=0.137N     P=0.339N     P=0.339N     P=0.181N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |34/50 (68%)  26/50 (52%)  32/50 (64%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      0/44.02      0/49.55     |34/46.48     26/45.66     32/48.34     29/47.03     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |73.2%        56.9%        66.2%        61.7%        | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |33/41 (81%)  25/37 (68%)  31/44 (71%)  28/43 (65%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |609          668          568          587          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.124N     P=0.167N     P=0.218N     P=0.104N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.254N     P=0.071N     P=0.301N     P=0.162N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.292N     P=0.070N     P=0.344N     P=0.185N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.208N     P=0.080N     P=0.263N     P=0.138N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.215N     P=0.098N     P=0.272N     P=0.147N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.321N     P=0.076N     P=0.417N     P=0.204N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |34/50 (68%)  31/50 (62%)  37/50 (74%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      0/44.02      0/49.55     |34/46.19     31/46.33     37/47.80     33/47.51     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |73.6%        66.9%        77.4%        69.5%        | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |33/41 (81%)  30/37 (81%)  37/44 (84%)  32/43 (74%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |698          325          733 (T)      226          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.274N     P=0.577      P=0.553      P=0.352N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.473N     P=0.310N     P=0.423      P=0.412N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.518N     P=0.310N     P=0.385      P=0.448N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.413N     P=0.344N     P=0.458      P=0.379N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.486N     P=0.386N     P=0.518      P=0.462N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.510      P=0.338N     P=0.330      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/50 (92%)  43/50 (86%)  44/49 (90%)  42/50 (84%) |49/50 (98%)  50/50 (100%) 50/50 (100%) 49/50 (98%)  | 
|POLY-3 RATE (b)    |     46/50.00     43/48.89     44/48.47     42/50.00    |49/49.24     50/50.00     50/50.00     49/49.97     | 
|POLY-3 PERCENT (g) |     92.0%        88.0%        90.8%        84.0%       |99.5%        100.0%       100.0%       98.1%        | 
|TERMINAL (d)       |     43/47 (92%)  41/46 (89%)  35/39 (90%)  41/49 (84%) |41/41 (100%) 37/37 (100%) 44/44 (100%) 43/43 (100%) | 
|FIRST INCIDENCE    |     100          594          365          596         |463          325          425          226          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.146N     P=0.384N     P=0.141      P=0.105N    |P=0.165N     P=0.176      P=0.365N     P=0.387N     | 
|POLY 3             |     P=0.156N     P=0.369N     P=0.557N     P=0.179N    |P=0.304N     P=0.999      P=0.999      P=0.609N     | 
|POLY 1.5           |     P=0.158N     P=0.361N     P=0.528N     P=0.179N    |P=0.413N     P=0.848      P=0.848      P=0.679N     | 
|POLY 6             |     P=0.154N     P=0.379N     P=0.591N     P=0.179N    |P=0.234N     P=1.000      P=1.000      P=0.552N     | 
|LOGISTIC REGRESSION|     P=0.162N     P=0.265N     P=0.474N     (e)         |P=0.655N     P=0.396      P=0.597      P=0.726      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.262N     P=0.487N     P=0.178N    |P=0.595N     P=0.500      P=0.500      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.41      1/48.13      0/44.02      0/49.55     |1/46.06      3/45.42      2/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |2.2%         6.6%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    1/46 (2%)    0/39 (0%)    0/49 (0%)   |1/41 (2%)    3/37 (8%)    2/44 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      ---          ---         |733 (T)      733 (T)      733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560N     P=0.496      (e)          (e)         |P=0.218N     P=0.269      P=0.525      P=0.490N     | 
|POLY 3             |     P=0.571N     P=0.499      (e)          (e)         |P=0.236N     P=0.300      P=0.513      P=0.498N     | 
|POLY 1.5           |     P=0.569N     P=0.499      (e)          (e)         |P=0.240N     P=0.303      P=0.508      P=0.500N     | 
|POLY 6             |     P=0.573N     P=0.498      (e)          (e)         |P=0.232N     P=0.295      P=0.518      P=0.496N     | 
|LOGISTIC REGRESSION|     (e)          P=0.496      (e)          (e)         |P=0.218N     P=0.269      P=0.525      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.242N     P=0.309      P=0.500      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |27/50 (54%)  23/50 (46%)  34/50 (68%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     1/48.41      1/48.13      0/44.90      1/49.55     |27/46.62     23/46.23     34/48.36     38/46.54     | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         2.0%        |57.9%        49.8%        70.3%        81.7%        | 
|TERMINAL (d)       |     1/47 (2%)    1/46 (2%)    0/39 (0%)    1/49 (2%)   |25/41 (61%)  21/37 (57%)  32/44 (73%)  38/43 (88%)  | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          728 (T)     |609          575          568          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605N     P=0.757      P=0.537N     P=0.752N    |P=0.009 **   P=0.450N     P=0.209      P=0.023 *    | 
|POLY 3             |     P=0.618N     P=0.759      P=0.515N     P=0.755N    |P<0.001 **   P=0.278N     P=0.144      P=0.008 **   | 
|POLY 1.5           |     P=0.616N     P=0.760      P=0.508N     P=0.756N    |P<0.001 **   P=0.274N     P=0.129      P=0.010 *    | 
|POLY 6             |     P=0.620N     P=0.758      P=0.523N     P=0.755N    |P<0.001 **   P=0.297N     P=0.157      P=0.008 **   | 
|LOGISTIC REGRESSION|     P=0.605N     P=0.757      (e)          P=0.752N    |P=0.003 **   P=0.304N     P=0.163      P=0.016 *    | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.753N     P=0.500N     P=0.753N    |P=0.003 **   P=0.274N     P=0.109      P=0.018 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  19/50 (38%)  20/50 (40%)  13/50 (26%) |10/50 (20%)  10/50 (20%)  12/50 (24%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     14/49.92     19/48.13     20/47.30     13/49.55    |10/46.92     10/47.53     12/48.93     12/47.97     | 
|POLY-3 PERCENT (g) |     28.0%        39.5%        42.3%        26.2%       |21.3%        21.0%        24.5%        25.0%        | 
|TERMINAL (d)       |     12/47 (26%)  19/46 (41%)  15/39 (39%)  13/49 (27%) |7/41 (17%)   4/37 (11%)   10/44 (23%)  9/43 (21%)   | 
|FIRST INCIDENCE    |     100          728 (T)      365          728 (T)     |609          325          425          379          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.329N     P=0.182      P=0.063      P=0.454N    |P=0.404      P=0.527      P=0.474      P=0.449      | 
|POLY 3             |     P=0.364N     P=0.163      P=0.103      P=0.509N    |P=0.345      P=0.586N     P=0.448      P=0.427      | 
|POLY 1.5           |     P=0.359N     P=0.170      P=0.119      P=0.505N    |P=0.333      P=0.587N     P=0.434      P=0.416      | 
|POLY 6             |     P=0.368N     P=0.154      P=0.087      P=0.513N    |P=0.358      P=0.593N     P=0.458      P=0.436      | 
|LOGISTIC REGRESSION|     P=0.380N     P=0.199      P=0.202      P=0.574N    |P=0.319      P=0.588N     P=0.374      P=0.407      | 
|COCH-ARM / FISHERS |     P=0.361N     P=0.198      P=0.146      P=0.500N    |P=0.322      P=0.598N     P=0.405      P=0.405      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |35/49 (71%)  30/50 (60%)  36/49 (73%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |                                                        |35/45.24     30/47.39     36/47.96     33/47.72     | 
|POLY-3 PERCENT (g) |                                                        |77.4%        63.3%        75.1%        69.2%        | 
|TERMINAL (d)       |                                                        |34/41 (83%)  23/37 (62%)  34/44 (77%)  31/43 (72%)  | 
|FIRST INCIDENCE    |                                                        |693          551          425          226          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.278N     P=0.423N     P=0.457N     P=0.272N     | 
|POLY 3             |                                                        |P=0.383N     P=0.098N     P=0.493N     P=0.249N     | 
|POLY 1.5           |                                                        |P=0.421N     P=0.121N     P=0.564N     P=0.291N     | 
|POLY 6             |                                                        |P=0.343N     P=0.080N     P=0.424N     P=0.209N     | 
|LOGISTIC REGRESSION|                                                        |P=0.440N     P=0.166N     P=0.534N     P=0.315N     | 
|COCH-ARM / FISHERS |                                                        |P=0.479N     P=0.162N     P=0.500      P=0.358N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     3/48.41      0/48.13      2/44.90      2/49.55     |                                                    | 
|POLY-3 PERCENT (g) |     6.2%         0.0%         4.5%         4.0%        |                                                    | 
|TERMINAL (d)       |     3/47 (6%)    0/46 (0%)    2/39 (5%)    2/49 (4%)   |                                                    | 
|FIRST INCIDENCE    |     728 (T)      ---          728 (T)      728 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.563N     P=0.125N     P=0.585N     P=0.481N    |                                                    | 
|POLY 3             |     P=0.573N     P=0.120N     P=0.534N     P=0.489N    |                                                    | 
|POLY 1.5           |     P=0.572N     P=0.120N     P=0.518N     P=0.490N    |                                                    | 
|POLY 6             |     P=0.572N     P=0.121N     P=0.553N     P=0.489N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.563N     (e)          P=0.585N     P=0.481N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.578N     P=0.121N     P=0.500N     P=0.500N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus                                                                                                                        | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/50 (8%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/48.92      2/48.69      4/47.54      0/49.55     |1/46.82      2/45.70      1/48.14      1/46.57      | 
|POLY-3 PERCENT (g) |     4.1%         4.1%         8.4%         0.0%        |2.1%         4.4%         2.1%         2.2%         | 
|TERMINAL (d)       |     1/47 (2%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     572          594          365          ---         |456          663          638          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.233N     P=0.690      P=0.313      P=0.233N    |P=0.517N     P=0.486      P=0.753N     P=0.760N     | 
|POLY 3             |     P=0.226N     P=0.692      P=0.324      P=0.235N    |P=0.529N     P=0.492      P=0.754N     P=0.759      | 
|POLY 1.5           |     P=0.225N     P=0.692      P=0.334      P=0.234N    |P=0.531N     P=0.495      P=0.757N     P=0.758      | 
|POLY 6             |     P=0.227N     P=0.691      P=0.312      P=0.235N    |P=0.526N     P=0.486      P=0.751N     P=0.760N     | 
|LOGISTIC REGRESSION|     P=0.354N     P=0.690N     P=0.414      P=0.277N    |P=0.494N     P=0.523      P=0.678      P=0.726N     | 
|COCH-ARM / FISHERS |     P=0.232N     P=0.691N     P=0.339      P=0.247N    |P=0.530N     P=0.500      P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/50 (4%)    4/49 (8%)   |6/50 (12%)   5/50 (10%)   5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     4/48.41      2/48.13      2/44.90      4/48.55     |6/46.06      5/45.42      5/47.80      3/46.54      | 
|POLY-3 PERCENT (g) |     8.3%         4.2%         4.5%         8.2%        |13.0%        11.0%        10.5%        6.5%         | 
|TERMINAL (d)       |     4/47 (9%)    2/46 (4%)    2/39 (5%)    4/48 (8%)   |6/41 (15%)   5/37 (14%)   5/44 (11%)   3/43 (7%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.505      P=0.347N     P=0.426N     P=0.632N    |P=0.156N     P=0.572N     P=0.450N     P=0.219N     | 
|POLY 3             |     P=0.496      P=0.340N     P=0.373N     P=0.641N    |P=0.187N     P=0.510N     P=0.474N     P=0.237N     | 
|POLY 1.5           |     P=0.497      P=0.339N     P=0.356N     P=0.642N    |P=0.194N     P=0.505N     P=0.484N     P=0.242N     | 
|POLY 6             |     P=0.496      P=0.343N     P=0.393N     P=0.640N    |P=0.179N     P=0.520N     P=0.465N     P=0.231N     | 
|LOGISTIC REGRESSION|     P=0.505      P=0.347N     P=0.426N     P=0.632N    |P=0.156N     P=0.572N     P=0.450N     P=0.219N     | 
|COCH-ARM / FISHERS |     P=0.489      P=0.339N     P=0.339N     P=0.631     |P=0.196N     P=0.500N     P=0.500N     P=0.243N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/4 (0%)     0/4 (0%)     0/1 (0%)     0/3 (0%)    |0/1 (0%)     1/4 (25%)    2/5 (40%)    0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/4.00       0/4.00       0/1.00       0/3.00      |0/1.00       1/3.63       2/5.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         27.6%        40.0%        0.0%         | 
|TERMINAL (d)       |     0/4 (0%)     0/4 (0%)     0/1 (0%)     0/3 (0%)    |0/1 (0%)     1/3 (33%)    2/5 (40%)    0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          733 (T)      733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.627      P=0.718      P=0.638      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          P=0.742      P=0.631      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          P=0.745      P=0.631      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          P=0.736      P=0.631      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.718      P=0.638      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.582      P=0.800      P=0.667      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/48.41      1/48.13      2/46.04      1/50.00     |1/46.19      1/45.46      0/47.80      2/47.08      | 
|POLY-3 PERCENT (g) |     4.1%         2.1%         4.3%         2.0%        |2.2%         2.2%         0.0%         4.3%         | 
|TERMINAL (d)       |     2/47 (4%)    1/46 (2%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      533          596         |698          723          ---          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.437N     P=0.508N     P=0.649      P=0.486N    |P=0.386      P=0.744      P=0.491N     P=0.511      | 
|POLY 3             |     P=0.434N     P=0.502N     P=0.676      P=0.489N    |P=0.374      P=0.757      P=0.493N     P=0.507      | 
|POLY 1.5           |     P=0.436N     P=0.501N     P=0.685      P=0.491N    |P=0.370      P=0.759      P=0.496N     P=0.502      | 
|POLY 6             |     P=0.432N     P=0.504N     P=0.665      P=0.486N    |P=0.379      P=0.753      P=0.491N     P=0.512      | 
|LOGISTIC REGRESSION|     P=0.508N     P=0.508N     P=0.694N     P=0.540N    |P=0.374      P=0.762      P=0.509N     P=0.514      | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.500N     P=0.691N     P=0.500N    |P=0.366      P=0.753N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/48.41      1/48.13      1/45.58      0/49.55     |1/46.80      2/45.42      1/47.80      2/47.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.2%         0.0%        |2.1%         4.4%         2.1%         4.2%         | 
|TERMINAL (d)       |     0/47 (0%)    1/46 (2%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    2/37 (5%)    1/44 (2%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      498          ---         |463          733 (T)      733 (T)      379          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.587N     P=0.496      P=0.500      (e)         |P=0.465      P=0.476      P=0.752N     P=0.501      | 
|POLY 3             |     P=0.589N     P=0.499      P=0.488      (e)         |P=0.453      P=0.490      P=0.756N     P=0.504      | 
|POLY 1.5           |     P=0.589N     P=0.499      P=0.494      (e)         |P=0.448      P=0.494      P=0.758N     P=0.501      | 
|POLY 6             |     P=0.590N     P=0.498      P=0.481      (e)         |P=0.459      P=0.483      P=0.754N     P=0.508      | 
|LOGISTIC REGRESSION|     P=0.663N     P=0.496      P=0.436      (e)         |P=0.494      P=0.515      P=0.701      P=0.627      | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.444      P=0.500      P=0.753N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    5/50 (10%)   0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      5/47.31      0/49.55     |1/46.82      0/45.42      1/48.14      1/46.57      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         10.6%        0.0%        |2.1%         0.0%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          365          ---         |456          ---          638          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.475      (e)          P=0.031 *    (e)         |P=0.546      P=0.504N     P=0.753N     P=0.760N     | 
|POLY 3             |     P=0.492      (e)          P=0.029 *    (e)         |P=0.542      P=0.506N     P=0.754N     P=0.759      | 
|POLY 1.5           |     P=0.488      (e)          P=0.030 *    (e)         |P=0.539      P=0.504N     P=0.757N     P=0.758      | 
|POLY 6             |     P=0.496      (e)          P=0.027 *    (e)         |P=0.548      P=0.510N     P=0.751N     P=0.760N     | 
|LOGISTIC REGRESSION|     P=0.309      (e)          P=0.023 *    (e)         |P=0.598      P=0.396N     P=0.678      P=0.726N     | 
|COCH-ARM / FISHERS |     P=0.469      (e)          P=0.028 *    (e)         |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      1/44.90      2/49.55     |1/46.80      0/45.42      0/47.80      2/47.08      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         4.0%        |2.1%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    1/39 (3%)    2/49 (4%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          728 (T)      728 (T)     |463          ---          ---          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079      (e)          P=0.463      P=0.248     |P=0.254      P=0.500N     P=0.500N     P=0.506      | 
|POLY 3             |     P=0.073      (e)          P=0.485      P=0.243     |P=0.251      P=0.506N     P=0.496N     P=0.502      | 
|POLY 1.5           |     P=0.073      (e)          P=0.492      P=0.242     |P=0.248      P=0.504N     P=0.497N     P=0.499      | 
|POLY 6             |     P=0.074      (e)          P=0.477      P=0.243     |P=0.255      P=0.510N     P=0.494N     P=0.506      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.463      P=0.248     |P=0.308      P=0.402N     P=0.603N     P=0.571      | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   3/50 (6%)    4/50 (8%)   |3/50 (6%)    4/50 (8%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/48.41      5/48.13      3/44.90      4/49.55     |3/46.06      4/45.42      0/47.80      2/46.54      | 
|POLY-3 PERCENT (g) |     8.3%         10.4%        6.7%         8.1%        |6.5%         8.8%         0.0%         4.3%         | 
|TERMINAL (d)       |     4/47 (9%)    5/46 (11%)   3/39 (8%)    4/49 (8%)   |3/41 (7%)    4/37 (11%)   0/44 (0%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      733 (T)      ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.480N     P=0.487      P=0.601N     P=0.620N    |P=0.231N     P=0.444      P=0.109N     P=0.478N     | 
|POLY 3             |     P=0.492N     P=0.496      P=0.541N     P=0.630N    |P=0.256N     P=0.492      P=0.112N     P=0.495N     | 
|POLY 1.5           |     P=0.491N     P=0.498      P=0.521N     P=0.631N    |P=0.260N     P=0.496      P=0.115N     P=0.499N     | 
|POLY 6             |     P=0.493N     P=0.493      P=0.563N     P=0.629N    |P=0.252N     P=0.484      P=0.110N     P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.480N     P=0.487      P=0.601N     P=0.620N    |P=0.231N     P=0.444      (e)          P=0.478N     | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.500N     P=0.643N    |P=0.263N     P=0.500      P=0.121N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/48.41      0/48.13      3/44.90      3/49.55     |0/46.06      0/45.42      0/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     6.2%         0.0%         6.7%         6.1%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     3/47 (6%)    0/46 (0%)    3/39 (8%)    3/49 (6%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      ---          728 (T)      728 (T)     |---          ---          ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403      P=0.125N     P=0.574      P=0.643N    |P=0.210      (e)          (e)          P=0.510      | 
|POLY 3             |     P=0.398      P=0.120N     P=0.627      P=0.651N    |P=0.201      (e)          (e)          P=0.502      | 
|POLY 1.5           |     P=0.397      P=0.120N     P=0.644      P=0.652N    |P=0.200      (e)          (e)          P=0.500      | 
|POLY 6             |     P=0.399      P=0.121N     P=0.607      P=0.650N    |P=0.204      (e)          (e)          P=0.504      | 
|LOGISTIC REGRESSION|     P=0.403      (e)          P=0.574      P=0.643N    |(e)          (e)          (e)          P=0.510      | 
|COCH-ARM / FISHERS |     P=0.386      P=0.121N     P=0.661N     P=0.661N    |P=0.198      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/48.41      2/48.13      2/44.90      0/49.55     |1/46.06      0/45.42      0/47.80      2/47.08      | 
|POLY-3 PERCENT (g) |     10.3%        4.2%         4.5%         0.0%        |2.2%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     5/47 (11%)   2/46 (4%)    2/39 (5%)    0/49 (0%)   |1/41 (2%)    0/37 (0%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      ---         |733 (T)      ---          ---          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023N*    P=0.226N     P=0.298N     P=0.030N*   |P=0.262      P=0.520N     P=0.486N     P=0.513      | 
|POLY 3             |     P=0.020N*    P=0.219N     P=0.248N     P=0.029N*   |P=0.251      P=0.503N     P=0.493N     P=0.508      | 
|POLY 1.5           |     P=0.020N*    P=0.218N     P=0.233N     P=0.029N*   |P=0.248      P=0.501N     P=0.495N     P=0.503      | 
|POLY 6             |     P=0.020N*    P=0.221N     P=0.267N     P=0.029N*   |P=0.256      P=0.506N     P=0.490N     P=0.514      | 
|LOGISTIC REGRESSION|     P=0.023N*    P=0.226N     P=0.298N     (e)         |P=0.253      (e)          (e)          P=0.508      | 
|COCH-ARM / FISHERS |     P=0.022N*    P=0.218N     P=0.218N     P=0.028N*   |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  42/50 (84%)  40/50 (80%)  44/50 (88%) |9/50 (18%)   0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     29/48.92     42/48.13     40/46.70     44/49.55    |9/49.41      0/48.13      0/44.90      0/49.55      | 
|POLY-3 PERCENT (g) |     59.3%        87.3%        85.7%        88.8%       |18.2%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     28/47 (60%)  42/46 (91%)  36/39 (92%)  44/49 (90%) |8/47 (17%)   0/46 (0%)    0/39 (0%)    0/49 (0%)    | 
|FIRST INCIDENCE    |     572          728 (T)      498          728 (T)     |100          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.002 **   P<0.001 **   P=0.002 **  |P<0.001N**   P=0.003N**   P=0.006N**   P=0.002N**   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P=0.003 **   P<0.001 **  |P<0.001N**   P=0.002N**   P=0.003N**   P=0.002N**   | 
|POLY 1.5           |     P<0.001 **   P=0.002 **   P=0.006 **   P<0.001 **  |P<0.001N**   P=0.002N**   P=0.002N**   P=0.002N**   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001N**   P=0.002N**   P=0.004N**   P=0.002N**   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.003 **   P=0.003 **   P<0.001 **  |P<0.001N**   P=0.002N**   P=0.002N**   P=0.004N**   | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.004 **   P=0.015 *    P<0.001 **  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      2/44.90      1/49.55     |1/46.06      1/45.52      1/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         2.0%        |2.2%         2.2%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    2/39 (5%)    1/49 (2%)   |1/41 (2%)    0/37 (0%)    1/44 (2%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          728 (T)      728 (T)     |733 (T)      708          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259      (e)          P=0.198      P=0.508     |P=0.608N     P=0.743      P=0.746N     P=0.751N     | 
|POLY 3             |     P=0.258      (e)          P=0.221      P=0.505     |P=0.627N     P=0.758      P=0.752N     P=0.758N     | 
|POLY 1.5           |     P=0.256      (e)          P=0.229      P=0.504     |P=0.630N     P=0.759      P=0.755N     P=0.760N     | 
|POLY 6             |     P=0.260      (e)          P=0.212      P=0.505     |P=0.623N     P=0.755      P=0.749N     P=0.756N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.198      P=0.508     |P=0.624N     P=0.759      P=0.746N     P=0.751N     | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.41      1/48.13      3/44.90      2/49.55     |1/46.48      1/45.42      3/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         6.7%         4.0%        |2.2%         2.2%         6.3%         2.2%         | 
|TERMINAL (d)       |     0/47 (0%)    1/46 (2%)    3/39 (8%)    2/49 (4%)   |0/41 (0%)    1/37 (3%)    3/44 (7%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      728 (T)      728 (T)     |609          733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.178      P=0.496      P=0.091      P=0.248     |P=0.583      P=0.747      P=0.330      P=0.755N     | 
|POLY 3             |     P=0.173      P=0.499      P=0.106      P=0.243     |P=0.560      P=0.755      P=0.316      P=0.760N     | 
|POLY 1.5           |     P=0.172      P=0.499      P=0.112      P=0.242     |P=0.555      P=0.758      P=0.312      P=0.760      | 
|POLY 6             |     P=0.175      P=0.498      P=0.099      P=0.243     |P=0.566      P=0.751      P=0.318      P=0.759N     | 
|LOGISTIC REGRESSION|     (e)          P=0.496      P=0.091      P=0.248     |P=0.556      P=0.758N     P=0.292      P=0.757N     | 
|COCH-ARM / FISHERS |     P=0.163      P=0.500      P=0.121      P=0.247     |P=0.556      P=0.753N     P=0.309      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     44/50 (88%)  49/50 (98%)  45/50 (90%)  46/50 (92%) |4/50 (8%)    1/50 (2%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     44/49.00     49/49.00     45/47.56     46/49.55    |4/47.00      1/45.42      2/47.83      6/46.54      | 
|POLY-3 PERCENT (g) |     89.8%        100.0%       94.6%        92.8%       |8.5%         2.2%         4.2%         12.9%        | 
|TERMINAL (d)       |     42/47 (89%)  46/46 (100%) 38/39 (97%)  46/49 (94%) |2/41 (5%)    1/37 (3%)    1/44 (2%)    6/43 (14%)   | 
|FIRST INCIDENCE    |     572          594          533          728 (T)     |570          733 (T)      726          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.431N     P=0.056      P=0.019 *    P=0.610     |P=0.186      P=0.202N     P=0.313N     P=0.397      | 
|POLY 3             |     P=0.574      P=0.031 *    P=0.299      P=0.428     |P=0.157      P=0.189N     P=0.329N     P=0.364      | 
|POLY 1.5           |     P=0.555N     P=0.030 *    P=0.411      P=0.448     |P=0.154      P=0.185N     P=0.332N     P=0.364      | 
|POLY 6             |     P=0.514      P=0.031 *    P=0.199      P=0.396     |P=0.162      P=0.198N     P=0.328N     P=0.364      | 
|LOGISTIC REGRESSION|     P=0.514N     P=0.034 *    P=0.226      P=0.505     |P=0.154      P=0.173N     P=0.375N     P=0.370      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.056      P=0.500      P=0.370     |P=0.154      P=0.181N     P=0.339N     P=0.370      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  46/50 (92%)  38/50 (76%)  42/50 (84%) |11/50 (22%)  4/50 (8%)    12/50 (24%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     47/49.92     46/48.44     38/45.45     42/49.55    |11/47.69     4/45.79      12/47.80     8/47.23      | 
|POLY-3 PERCENT (g) |     94.2%        95.0%        83.6%        84.8%       |23.1%        8.7%         25.1%        16.9%        | 
|TERMINAL (d)       |     45/47 (96%)  45/46 (98%)  37/39 (95%)  42/49 (86%) |8/41 (20%)   3/37 (8%)    12/44 (27%)  6/43 (14%)   | 
|FIRST INCIDENCE    |     100          644          561          728 (T)     |463          628          733 (T)      587          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006N**   P=0.656N     P=0.456N     P=0.034N*   |P=0.415N     P=0.071N     P=0.567      P=0.283N     | 
|POLY 3             |     P=0.032N*    P=0.608      P=0.073N     P=0.112N    |P=0.477N     P=0.052N     P=0.503      P=0.313N     | 
|POLY 1.5           |     P=0.034N*    P=0.640      P=0.032N*    P=0.106N    |P=0.488N     P=0.049N*    P=0.501      P=0.316N     | 
|POLY 6             |     P=0.032N*    P=0.564      P=0.183N     P=0.118N    |P=0.457N     P=0.057N     P=0.504      P=0.305N     | 
|LOGISTIC REGRESSION|     P=0.018N*    P=0.513N     P=0.023N*    P=0.094N    |P=0.488N     P=0.043N*    P=0.483      P=0.300N     | 
|COCH-ARM / FISHERS |     P=0.050N     P=0.500N     P=0.011N*    P=0.100N    |P=0.488N     P=0.045N*    P=0.500      P=0.306N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   8/50 (16%)   9/50 (18%)  |25/50 (50%)  30/50 (60%)  22/50 (44%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     7/48.41      5/48.13      8/44.90      9/49.55     |25/47.88     30/48.65     22/48.13     32/47.08     | 
|POLY-3 PERCENT (g) |     14.5%        10.4%        17.8%        18.2%       |52.2%        61.7%        45.7%        68.0%        | 
|TERMINAL (d)       |     7/47 (15%)   5/46 (11%)   8/39 (21%)   9/49 (18%)  |20/41 (49%)  22/37 (60%)  21/44 (48%)  31/43 (72%)  | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |456          325          642          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.265      P=0.394N     P=0.346      P=0.428     |P=0.316      P=0.132      P=0.250N     P=0.176      | 
|POLY 3             |     P=0.252      P=0.384N     P=0.437      P=0.413     |P=0.126      P=0.231      P=0.332N     P=0.084      | 
|POLY 1.5           |     P=0.252      P=0.382N     P=0.467      P=0.411     |P=0.131      P=0.224      P=0.338N     P=0.088      | 
|POLY 6             |     P=0.253      P=0.387N     P=0.403      P=0.414     |P=0.124      P=0.233      P=0.326N     P=0.083      | 
|LOGISTIC REGRESSION|     P=0.265      P=0.394N     P=0.346      P=0.428     |P=0.166      P=0.214      P=0.317N     P=0.112      | 
|COCH-ARM / FISHERS |     P=0.238      P=0.380N     P=0.500      P=0.393     |P=0.163      P=0.211      P=0.344N     P=0.113      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |4/49 (8%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/48.41      3/48.13      1/44.90      0/49.55     |4/45.21      2/45.42      1/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     6.2%         6.2%         2.2%         0.0%        |8.9%         4.4%         2.1%         0.0%         | 
|TERMINAL (d)       |     3/47 (6%)    3/46 (7%)    1/39 (3%)    0/49 (0%)   |4/41 (10%)   2/37 (5%)    1/44 (2%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      ---         |733 (T)      733 (T)      733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054N     P=0.653      P=0.374N     P=0.114N    |P=0.025N*    P=0.385N     P=0.159N     P=0.057N     | 
|POLY 3             |     P=0.051N     P=0.659      P=0.333N     P=0.115N    |P=0.027N*    P=0.335N     P=0.162N     P=0.057N     | 
|POLY 1.5           |     P=0.051N     P=0.660      P=0.320N     P=0.115N    |P=0.027N*    P=0.332N     P=0.166N     P=0.058N     | 
|POLY 6             |     P=0.051N     P=0.657      P=0.349N     P=0.115N    |P=0.026N*    P=0.343N     P=0.159N     P=0.055N     | 
|LOGISTIC REGRESSION|     P=0.054N     P=0.653      P=0.374N     (e)         |P=0.025N*    P=0.385N     P=0.159N     (e)          | 
|COCH-ARM / FISHERS |     P=0.052N     P=0.661N     P=0.309N     P=0.121N    |P=0.028N*    P=0.329N     P=0.175N     P=0.056N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.41      3/48.13      2/44.90      1/49.55     |1/45.21      2/45.64      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     2.1%         6.2%         4.5%         2.0%        |2.2%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/47 (2%)    3/46 (7%)    2/39 (5%)    1/49 (2%)   |1/41 (2%)    1/37 (3%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      673          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.462N     P=0.298      P=0.435      P=0.752N    |P=0.177N     P=0.468      P=0.486N     P=0.490N     | 
|POLY 3             |     P=0.466N     P=0.304      P=0.474      P=0.755N    |P=0.183N     P=0.503      P=0.489N     P=0.494N     | 
|POLY 1.5           |     P=0.466N     P=0.304      P=0.486      P=0.756N    |P=0.184N     P=0.505      P=0.491N     P=0.496N     | 
|POLY 6             |     P=0.467N     P=0.302      P=0.459      P=0.755N    |P=0.181N     P=0.499      P=0.487N     P=0.492N     | 
|LOGISTIC REGRESSION|     P=0.462N     P=0.298      P=0.435      P=0.752N    |P=0.184N     P=0.505      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.309      P=0.500      P=0.753N    |P=0.185N     P=0.508      P=0.495N     P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    4/50 (8%)    2/50 (4%)   |4/49 (8%)    8/50 (16%)   4/50 (8%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     3/48.41      4/48.59      4/44.90      2/49.55     |4/46.11      8/45.99      4/47.80      7/46.54      | 
|POLY-3 PERCENT (g) |     6.2%         8.2%         8.9%         4.0%        |8.7%         17.4%        8.4%         15.0%        | 
|TERMINAL (d)       |     3/47 (6%)    3/46 (7%)    4/39 (10%)   2/49 (4%)   |2/41 (5%)    7/37 (19%)   4/44 (9%)    7/43 (16%)   | 
|FIRST INCIDENCE    |     728 (T)      594          728 (T)      728 (T)     |456          551          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.355N     P=0.492      P=0.399      P=0.481N    |P=0.399      P=0.147      P=0.611N     P=0.286      | 
|POLY 3             |     P=0.358N     P=0.502      P=0.459      P=0.489N    |P=0.348      P=0.175      P=0.623N     P=0.267      | 
|POLY 1.5           |     P=0.358N     P=0.501      P=0.479      P=0.490N    |P=0.346      P=0.181      P=0.626N     P=0.266      | 
|POLY 6             |     P=0.358N     P=0.502      P=0.436      P=0.489N    |P=0.352      P=0.166      P=0.621N     P=0.267      | 
|LOGISTIC REGRESSION|     P=0.361N     P=0.500      P=0.399      P=0.481N    |P=0.352      P=0.191      P=0.625      P=0.273      | 
|COCH-ARM / FISHERS |     P=0.367N     P=0.500      P=0.500      P=0.500N    |P=0.351      P=0.188      P=0.631N     P=0.274      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |6/49 (12%)   3/50 (6%)    2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/48.41      1/48.24      1/45.19      0/49.55     |6/46.10      3/45.89      2/47.80      5/47.08      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.2%         0.0%        |13.0%        6.5%         4.2%         10.6%        | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |4/41 (10%)   1/37 (3%)    2/44 (5%)    4/43 (9%)    | 
|FIRST INCIDENCE    |     ---          701          652          ---         |463          628          733 (T)      568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.590N     P=0.496      P=0.478      (e)         |P=0.457N     P=0.283N     P=0.121N     P=0.475N     | 
|POLY 3             |     P=0.590N     P=0.499      P=0.486      (e)         |P=0.482N     P=0.244N     P=0.122N     P=0.485N     | 
|POLY 1.5           |     P=0.590N     P=0.500      P=0.493      (e)         |P=0.487N     P=0.240N     P=0.124N     P=0.489N     | 
|POLY 6             |     P=0.590N     P=0.499      P=0.479      (e)         |P=0.474N     P=0.252N     P=0.121N     P=0.480N     | 
|LOGISTIC REGRESSION|     P=0.616N     P=0.501      P=0.502      (e)         |P=0.488N     P=0.225N     P=0.143N     P=0.480N     | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.490N     P=0.233N     P=0.128N     P=0.486N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  34/50 (68%)  28/50 (56%)  27/50 (54%) |42/49 (86%)  36/50 (72%)  38/50 (76%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     33/48.92     34/48.13     28/45.58     27/49.55    |42/47.80     36/47.22     38/48.13     41/49.11     | 
|POLY-3 PERCENT (g) |     67.5%        70.6%        61.4%        54.5%       |87.9%        76.2%        79.0%        83.5%        | 
|TERMINAL (d)       |     32/47 (68%)  34/46 (74%)  27/39 (69%)  27/49 (55%) |37/41 (90%)  30/37 (81%)  37/44 (84%)  37/43 (86%)  | 
|FIRST INCIDENCE    |     572          728 (T)      498          728 (T)     |463          575          642          226          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047N*    P=0.438      P=0.540      P=0.101N    |P=0.289N     P=0.375N     P=0.075N     P=0.338N     | 
|POLY 3             |     P=0.060N     P=0.452      P=0.344N     P=0.133N    |P=0.468N     P=0.104N     P=0.177N     P=0.370N     | 
|POLY 1.5           |     P=0.059N     P=0.472      P=0.268N     P=0.131N    |P=0.491N     P=0.091N     P=0.170N     P=0.380N     | 
|POLY 6             |     P=0.061N     P=0.422      P=0.449N     P=0.137N    |P=0.452N     P=0.125N     P=0.191N     P=0.371N     | 
|LOGISTIC REGRESSION|     P=0.058N     P=0.483      P=0.393N     P=0.123N    |P=0.537N     P=0.075N     P=0.100N     P=0.414N     | 
|COCH-ARM / FISHERS |     P=0.078N     P=0.500      P=0.206N     P=0.154N    |P=0.541N     P=0.077N     P=0.166N     P=0.410N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    3/50 (6%)    6/50 (12%)  |1/49 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/48.41      3/48.13      3/44.90      6/49.55     |1/45.21      3/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     10.3%        6.2%         6.7%         12.1%       |2.2%         6.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/47 (11%)   3/46 (7%)    3/39 (8%)    6/49 (12%)  |1/41 (2%)    3/37 (8%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      733 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.373      P=0.368N     P=0.462N     P=0.529     |P=0.139N     P=0.269      P=0.486N     P=0.490N     | 
|POLY 3             |     P=0.359      P=0.360N     P=0.399N     P=0.516     |P=0.146N     P=0.307      P=0.489N     P=0.494N     | 
|POLY 1.5           |     P=0.359      P=0.359N     P=0.378N     P=0.515     |P=0.147N     P=0.310      P=0.491N     P=0.496N     | 
|POLY 6             |     P=0.359      P=0.363N     P=0.423N     P=0.517     |P=0.145N     P=0.300      P=0.487N     P=0.492N     | 
|LOGISTIC REGRESSION|     P=0.373      P=0.368N     P=0.462N     P=0.529     |P=0.139N     P=0.269      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.350      P=0.357N     P=0.357N     P=0.500     |P=0.150N     P=0.316      P=0.495N     P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    4/50 (8%)    3/50 (6%)   |2/49 (4%)    2/50 (4%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/48.92      4/48.44      4/45.29      3/49.55     |2/45.21      2/46.03      1/47.80      3/47.40      | 
|POLY-3 PERCENT (g) |     12.3%        8.3%         8.8%         6.1%        |4.4%         4.3%         2.1%         6.3%         | 
|TERMINAL (d)       |     5/47 (11%)   3/46 (7%)    2/39 (5%)    3/49 (6%)   |2/41 (5%)    0/37 (0%)    1/44 (2%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     572          644          652          728 (T)     |733 (T)      551          733 (T)      379          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.206N     P=0.383N     P=0.481N     P=0.226N    |P=0.433      P=0.671      P=0.475N     P=0.515      | 
|POLY 3             |     P=0.206N     P=0.376N     P=0.419N     P=0.237N    |P=0.423      P=0.687N     P=0.481N     P=0.522      | 
|POLY 1.5           |     P=0.204N     P=0.374N     P=0.396N     P=0.236N    |P=0.417      P=0.686N     P=0.485N     P=0.516      | 
|POLY 6             |     P=0.208N     P=0.380N     P=0.445N     P=0.239N    |P=0.430      P=0.691N     P=0.477N     P=0.527      | 
|LOGISTIC REGRESSION|     P=0.209N     P=0.368N     P=0.367N     P=0.253N    |P=0.431      P=0.684N     P=0.475N     P=0.529      | 
|COCH-ARM / FISHERS |     P=0.208N     P=0.370N     P=0.370N     P=0.243N    |P=0.410      P=0.684N     P=0.492N     P=0.510      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |3/49 (6%)    4/50 (8%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/48.41      1/48.13      1/44.90      1/49.55     |3/45.64      4/45.46      2/47.80      4/47.08      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.2%         2.0%        |6.6%         8.8%         4.2%         8.5%         | 
|TERMINAL (d)       |     0/47 (0%)    1/46 (2%)    1/39 (3%)    1/49 (2%)   |2/41 (5%)    3/37 (8%)    2/44 (5%)    3/43 (7%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      728 (T)      728 (T)     |609          723          733 (T)      568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.395      P=0.496      P=0.463      P=0.508     |P=0.524      P=0.453      P=0.471N     P=0.520      | 
|POLY 3             |     P=0.395      P=0.499      P=0.485      P=0.505     |P=0.501      P=0.498      P=0.479N     P=0.517      | 
|POLY 1.5           |     P=0.394      P=0.499      P=0.492      P=0.504     |P=0.494      P=0.504      P=0.483N     P=0.512      | 
|POLY 6             |     P=0.396      P=0.498      P=0.477      P=0.505     |P=0.509      P=0.486      P=0.477N     P=0.522      | 
|LOGISTIC REGRESSION|     (e)          P=0.496      P=0.463      P=0.508     |P=0.490      P=0.507      P=0.497N     P=0.515      | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.490      P=0.511      P=0.490N     P=0.511      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      0/44.90      1/49.55     |1/45.21      2/45.52      0/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.0%        |2.2%         4.4%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    1/49 (2%)   |1/41 (2%)    1/37 (3%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          728 (T)     |733 (T)      708          ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      (e)          (e)          P=0.508     |P=0.474N     P=0.471      P=0.486N     P=0.751N     | 
|POLY 3             |     P=0.202      (e)          (e)          P=0.505     |P=0.491N     P=0.502      P=0.489N     P=0.754N     | 
|POLY 1.5           |     P=0.202      (e)          (e)          P=0.504     |P=0.493N     P=0.505      P=0.491N     P=0.756N     | 
|POLY 6             |     P=0.203      (e)          (e)          P=0.505     |P=0.489N     P=0.497      P=0.487N     P=0.752N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.508     |P=0.486N     P=0.497      (e)          P=0.751N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.495N     P=0.508      P=0.495N     P=0.747N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   8/50 (16%)   3/50 (6%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.41      6/48.13      8/44.90      3/49.55     |2/48.41      0/48.13      0/44.90      0/49.55      | 
|POLY-3 PERCENT (g) |     2.1%         12.5%        17.8%        6.1%        |4.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/47 (2%)    6/46 (13%)   8/39 (21%)   3/49 (6%)   |2/47 (4%)    0/46 (0%)    0/39 (0%)    0/49 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |728 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424      P=0.056      P=0.008 **   P=0.321     |P=0.119N     P=0.243N     P=0.280N     P=0.229N     | 
|POLY 3             |     P=0.424      P=0.055      P=0.011 *    P=0.314     |P=0.116N     P=0.239N     P=0.254N     P=0.232N     | 
|POLY 1.5           |     P=0.422      P=0.056      P=0.013 *    P=0.313     |P=0.115N     P=0.238N     P=0.246N     P=0.233N     | 
|POLY 6             |     P=0.427      P=0.055      P=0.009 **   P=0.315     |P=0.117N     P=0.240N     P=0.264N     P=0.232N     | 
|LOGISTIC REGRESSION|     P=0.424      P=0.056      P=0.008 **   P=0.321     |P=0.119N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.401      P=0.056      P=0.015 *    P=0.309     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.41      1/48.13      3/44.90      1/50.00     |1/46.19      0/45.42      3/48.34      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         6.7%         2.0%        |2.2%         0.0%         6.2%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    1/46 (2%)    3/39 (8%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    2/44 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      728 (T)      596         |698          ---          568          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.365      P=0.496      P=0.091      P=0.508     |P=0.481N     P=0.514N     P=0.328      P=0.495N     | 
|POLY 3             |     P=0.373      P=0.499      P=0.106      P=0.506     |P=0.494N     P=0.503N     P=0.322      P=0.498N     | 
|POLY 1.5           |     P=0.368      P=0.499      P=0.112      P=0.505     |P=0.499N     P=0.502N     P=0.316      P=0.500N     | 
|POLY 6             |     P=0.379      P=0.498      P=0.099      P=0.508     |P=0.486N     P=0.507N     P=0.328      P=0.497N     | 
|LOGISTIC REGRESSION|     P=0.343      P=0.496      P=0.091      P=0.412     |P=0.494N     P=0.499N     P=0.271      P=0.499N     | 
|COCH-ARM / FISHERS |     P=0.351      P=0.500      P=0.121      P=0.500     |P=0.500N     P=0.500N     P=0.309      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   0/50 (0%)    5/50 (10%)  |1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/48.41      7/48.13      0/44.90      5/49.55     |1/46.06      0/45.42      2/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     4.1%         14.5%        0.0%         10.1%       |2.2%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     2/47 (4%)    7/46 (15%)   0/39 (0%)    5/49 (10%)  |1/41 (2%)    0/37 (0%)    2/44 (5%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          728 (T)     |733 (T)      ---          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.410      P=0.076      P=0.280N     P=0.234     |P=0.527      P=0.520N     P=0.525      P=0.751N     | 
|POLY 3             |     P=0.392      P=0.078      P=0.254N     P=0.227     |P=0.507      P=0.503N     P=0.513      P=0.758N     | 
|POLY 1.5           |     P=0.394      P=0.079      P=0.246N     P=0.226     |P=0.502      P=0.501N     P=0.508      P=0.760N     | 
|POLY 6             |     P=0.389      P=0.077      P=0.264N     P=0.227     |P=0.515      P=0.506N     P=0.518      P=0.756N     | 
|LOGISTIC REGRESSION|     P=0.410      P=0.076      (e)          P=0.234     |P=0.527      (e)          P=0.525      P=0.751N     | 
|COCH-ARM / FISHERS |     P=0.390      P=0.080      P=0.247N     P=0.218     |P=0.500      P=0.500N     P=0.500      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/46 (0%)    2/46 (4%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.92      0/45.59      2/41.91      0/49.55     |1/45.59      0/45.42      0/46.80      0/46.54      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.8%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/47 (2%)    0/44 (0%)    1/37 (3%)    0/49 (0%)   |1/41 (2%)    0/37 (0%)    0/43 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      ---          652          ---         |733 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454N     P=0.513N     P=0.430      P=0.492N    |P=0.297N     P=0.520N     P=0.490N     P=0.490N     | 
|POLY 3             |     P=0.450N     P=0.510N     P=0.453      P=0.493N    |P=0.301N     P=0.501N     P=0.495N     P=0.496N     | 
|POLY 1.5           |     P=0.450N     P=0.510N     P=0.465      P=0.493N    |P=0.302N     P=0.499N     P=0.497N     P=0.497N     | 
|POLY 6             |     P=0.450N     P=0.511N     P=0.441      P=0.494N    |P=0.299N     P=0.505N     P=0.493N     P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.460N     (e)          P=0.480      (e)         |P=0.297N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.453N     P=0.516N     P=0.476      P=0.495N    |P=0.304N     P=0.495N     P=0.500N     P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/46 (0%)    1/46 (2%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.92      0/45.59      1/41.63      1/49.55     |0/45.59      0/45.42      0/46.80      0/46.54      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.4%         2.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/47 (4%)    0/44 (0%)    1/37 (3%)    1/49 (2%)   |0/41 (0%)    0/37 (0%)    0/43 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      ---          728 (T)      728 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488N     P=0.253N     P=0.583N     P=0.485N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.493N     P=0.249N     P=0.549N     P=0.488N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.492N     P=0.248N     P=0.536N     P=0.488N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.494N     P=0.250N     P=0.563N     P=0.490N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.488N     (e)          P=0.583N     P=0.485N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.490N     P=0.263N     P=0.524N     P=0.492N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)    |0/4 (0%)     2/5 (40%)    0/4 (0%)     1/1 (100%)   | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/0.90       0/0.00      |0/3.59       2/4.40       0/3.48       1/1.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         45.5%        0.0%         100.0%       | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/3 (0%)     2/3 (67%)    0/1 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          733 (T)      ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.191      P=0.215      (e)          P=0.282      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.162      P=0.251      (e)          P<0.001 **   | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.164      P=0.255      (e)          P<0.001 **   | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.161      P=0.248      (e)          P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.215      (e)          P=0.282      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.207      P=0.278      (e)          P=0.200      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)    |3/4 (75%)    2/5 (40%)    1/4 (25%)    1/1 (100%)   | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/0.90       0/0.00      |3/3.59       2/4.40       1/3.48       1/1.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |83.6%        45.5%        28.7%        100.0%       | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |3/3 (100%)   2/3 (67%)    1/1 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.755      P=0.500N     P=1.000      P=1.000      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.642N     P=0.352N     P=0.215N     P=0.903      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.618N     P=0.358N     P=0.225N     P=0.827      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.684N     P=0.337N     P=0.208N     P=0.991      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.755      P=0.500N     P=1.000      P=1.000      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.598N     P=0.357N     P=0.243N     P=0.800      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    3/48 (6%)    0/48 (0%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.92      3/46.69      0/44.04      3/50.00     |1/46.06      0/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     2.1%         6.4%         0.0%         6.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/46 (2%)    3/46 (7%)    0/39 (0%)    2/49 (4%)   |1/41 (2%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          596         |733 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      P=0.306      P=0.533N     P=0.328     |P=0.296N     P=0.520N     P=0.486N     P=0.490N     | 
|POLY 3             |     P=0.345      P=0.304      P=0.513N     P=0.329     |P=0.304N     P=0.503N     P=0.493N     P=0.498N     | 
|POLY 1.5           |     P=0.346      P=0.304      P=0.506N     P=0.328     |P=0.304N     P=0.501N     P=0.495N     P=0.500N     | 
|POLY 6             |     P=0.344      P=0.303      P=0.520N     P=0.329     |P=0.303N     P=0.506N     P=0.490N     P=0.496N     | 
|LOGISTIC REGRESSION|     P=0.337      P=0.306      (e)          P=0.289     |P=0.296N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.341      P=0.308      P=0.500N     P=0.324     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    6/48 (13%)   0/48 (0%)    4/50 (8%)   |5/50 (10%)   3/50 (6%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.92      6/46.69      0/44.04      4/49.55     |5/46.06      3/45.42      4/48.34      2/46.54      | 
|POLY-3 PERCENT (g) |     4.3%         12.9%        0.0%         8.1%        |10.9%        6.6%         8.3%         4.3%         | 
|TERMINAL (d)       |     2/46 (4%)    6/46 (13%)   0/39 (0%)    4/49 (8%)   |5/41 (12%)   3/37 (8%)    3/44 (7%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          728 (T)     |733 (T)      733 (T)      568          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.526      P=0.135      P=0.276N     P=0.367     |P=0.169N     P=0.413N     P=0.458N     P=0.198N     | 
|POLY 3             |     P=0.524      P=0.132      P=0.252N     P=0.363     |P=0.192N     P=0.364N     P=0.470N     P=0.212N     | 
|POLY 1.5           |     P=0.527      P=0.132      P=0.244N     P=0.364     |P=0.197N     P=0.361N     P=0.481N     P=0.216N     | 
|POLY 6             |     P=0.519      P=0.131      P=0.260N     P=0.361     |P=0.184N     P=0.372N     P=0.458N     P=0.207N     | 
|LOGISTIC REGRESSION|     P=0.526      P=0.135      (e)          P=0.367     |P=0.192N     P=0.413N     P=0.496N     P=0.198N     | 
|COCH-ARM / FISHERS |     P=0.523      P=0.134      P=0.247N     P=0.359     |P=0.200N     P=0.357N     P=0.500N     P=0.218N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/48 (4%)    1/48 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.92      2/46.69      1/44.04      0/49.55     |0/46.06      0/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/46 (0%)    2/46 (4%)    1/39 (3%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      728 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.449N     P=0.239      P=0.467      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.448N     P=0.236      P=0.487      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.446N     P=0.237      P=0.494      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.450N     P=0.236      P=0.480      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.239      P=0.467      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.450N     P=0.247      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    2/48 (4%)    1/48 (2%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.92      2/46.69      1/44.04      3/49.55     |1/46.06      0/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         2.3%         6.1%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/46 (4%)    2/46 (4%)    1/39 (3%)    3/49 (6%)   |1/41 (2%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.427      P=0.694      P=0.558N     P=0.529     |P=0.296N     P=0.520N     P=0.486N     P=0.490N     | 
|POLY 3             |     P=0.425      P=0.692      P=0.522N     P=0.525     |P=0.304N     P=0.503N     P=0.493N     P=0.498N     | 
|POLY 1.5           |     P=0.427      P=0.692      P=0.511N     P=0.526     |P=0.304N     P=0.501N     P=0.495N     P=0.500N     | 
|POLY 6             |     P=0.423      P=0.691      P=0.535N     P=0.523     |P=0.303N     P=0.506N     P=0.490N     P=0.496N     | 
|LOGISTIC REGRESSION|     P=0.427      P=0.694      P=0.558N     P=0.529     |P=0.296N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.422      P=0.692N     P=0.500N     P=0.520     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/48 (2%)    0/48 (0%)    0/50 (0%)   |23/50 (46%)  25/50 (50%)  22/50 (44%)  0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.92      1/46.69      0/44.04      0/49.55     |23/47.64     25/47.38     22/49.64     0/46.54      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         0.0%         0.0%        |48.3%        52.8%        44.3%        0.0%         | 
|TERMINAL (d)       |     2/46 (4%)    1/46 (2%)    0/39 (0%)    0/49 (0%)   |20/41 (49%)  19/37 (51%)  18/44 (41%)  0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          ---         |463          325          425          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.102N     P=0.500N     P=0.276N     P=0.225N    |P<0.001N**   P=0.279      P=0.390N     P<0.001N**   | 
|POLY 3             |     P=0.098N     P=0.502N     P=0.252N     P=0.225N    |P<0.001N**   P=0.408      P=0.426N     P<0.001N**   | 
|POLY 1.5           |     P=0.098N     P=0.501N     P=0.244N     P=0.225N    |P<0.001N**   P=0.418      P=0.453N     P<0.001N**   | 
|POLY 6             |     P=0.099N     P=0.503N     P=0.260N     P=0.226N    |P<0.001N**   P=0.385      P=0.400N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.500N     (e)          (e)         |P<0.001N**   P=0.417      P=0.527N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.097N     P=0.500N     P=0.247N     P=0.237N    |P<0.001N**   P=0.421      P=0.500N     P<0.001N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    3/48 (6%)    26/50 (52%) |0/50 (0%)    0/50 (0%)    8/50 (16%)   46/50 (92%)  | 
|POLY-3 RATE (b)    |     0/46.92      0/46.69      3/44.04      26/49.55    |0/46.06      0/45.42      8/47.80      46/48.54     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.8%         52.5%       |0.0%         0.0%         16.7%        94.8%        | 
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    3/39 (8%)    26/49 (53%) |0/41 (0%)    0/37 (0%)    8/44 (18%)   41/43 (95%)  | 
|FIRST INCIDENCE    |     ---          ---          728 (T)      728 (T)     |---          ---          733 (T)      379          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.094      P<0.001 **  |P<0.001 **   (e)          P=0.007 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   (e)          P=0.108      P<0.001 **  |P<0.001 **   (e)          P=0.004 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.113      P<0.001 **  |P<0.001 **   (e)          P=0.004 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   (e)          P=0.102      P<0.001 **  |P<0.001 **   (e)          P=0.005 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.094      P<0.001 **  |P<0.001 **   (e)          P=0.007 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.121      P<0.001 **  |P<0.001 **   (e)          P=0.003 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  8/50 (16%)   11/49 (22%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |                                                        |10/46.19     8/46.50      11/47.36     11/47.28     | 
|POLY-3 PERCENT (g) |                                                        |21.7%        17.2%        23.2%        23.3%        | 
|TERMINAL (d)       |                                                        |9/41 (22%)   5/37 (14%)   10/44 (23%)  9/43 (21%)   | 
|FIRST INCIDENCE    |                                                        |698          575          568          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.444      P=0.477N     P=0.569      P=0.544      | 
|POLY 3             |                                                        |P=0.383      P=0.391N     P=0.526      P=0.524      | 
|POLY 1.5           |                                                        |P=0.368      P=0.393N     P=0.508      P=0.509      | 
|POLY 6             |                                                        |P=0.405      P=0.394N     P=0.543      P=0.542      | 
|LOGISTIC REGRESSION|                                                        |P=0.361      P=0.403N     P=0.514      P=0.507      | 
|COCH-ARM / FISHERS |                                                        |P=0.358      P=0.398N     P=0.479      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    1/49 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |2/46.06      1/45.42      1/46.83      3/47.08      | 
|POLY-3 PERCENT (g) |                                                        |4.3%         2.2%         2.1%         6.4%         | 
|TERMINAL (d)       |                                                        |2/41 (5%)    1/37 (3%)    1/44 (2%)    2/43 (5%)    | 
|FIRST INCIDENCE    |                                                        |733 (T)      733 (T)      733 (T)      568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.356      P=0.536N     P=0.475N     P=0.519      | 
|POLY 3             |                                                        |P=0.335      P=0.505N     P=0.494N     P=0.510      | 
|POLY 1.5           |                                                        |P=0.329      P=0.502N     P=0.499N     P=0.504      | 
|POLY 6             |                                                        |P=0.344      P=0.510N     P=0.490N     P=0.518      | 
|LOGISTIC REGRESSION|                                                        |P=0.324      P=0.536N     P=0.475N     P=0.501      | 
|COCH-ARM / FISHERS |                                                        |P=0.324      P=0.500N     P=0.508N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  8/50 (16%)   14/50 (28%)  10/50 (20%) |25/50 (50%)  16/50 (32%)  24/50 (48%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     10/48.41     8/48.13      14/45.01     10/49.55    |25/46.80     16/45.75     24/47.80     18/46.54     | 
|POLY-3 PERCENT (g) |     20.7%        16.6%        31.1%        20.2%       |53.4%        35.0%        50.2%        38.7%        | 
|TERMINAL (d)       |     10/47 (21%)  8/46 (17%)   13/39 (33%)  10/49 (20%) |24/41 (59%)  14/37 (38%)  24/44 (55%)  18/43 (42%)  | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      702          728 (T)     |463          652          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.465      P=0.417N     P=0.108      P=0.558N    |P=0.108N     P=0.103N     P=0.359N     P=0.069N     | 
|POLY 3             |     P=0.457      P=0.403N     P=0.179      P=0.576N    |P=0.195N     P=0.054N     P=0.458N     P=0.108N     | 
|POLY 1.5           |     P=0.455      P=0.401N     P=0.208      P=0.578N    |P=0.208N     P=0.052N     P=0.474N     P=0.114N     | 
|POLY 6             |     P=0.460      P=0.407N     P=0.150      P=0.574N    |P=0.176N     P=0.058N     P=0.440N     P=0.100N     | 
|LOGISTIC REGRESSION|     P=0.452      P=0.417N     P=0.118      P=0.558N    |P=0.154N     P=0.057N     P=0.406N     P=0.093N     | 
|COCH-ARM / FISHERS |     P=0.430      P=0.398N     P=0.241      P=0.598N    |P=0.212N     P=0.052N     P=0.500N     P=0.113N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    1/50 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.41      3/47.13      0/44.90      0/48.55     |0/45.09      1/45.42      2/46.80      0/46.54      | 
|POLY-3 PERCENT (g) |     2.1%         6.4%         0.0%         0.0%        |0.0%         2.2%         4.3%         0.0%         | 
|TERMINAL (d)       |     1/47 (2%)    3/45 (7%)    0/39 (0%)    0/48 (0%)   |0/41 (0%)    1/37 (3%)    2/43 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          ---         |---          733 (T)      733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157N     P=0.290      P=0.537N     P=0.496N    |P=0.593N     P=0.480      P=0.249      (e)          | 
|POLY 3             |     P=0.154N     P=0.296      P=0.515N     P=0.499N    |P=0.607N     P=0.501      P=0.246      (e)          | 
|POLY 1.5           |     P=0.152N     P=0.297      P=0.508N     P=0.500N    |P=0.611N     P=0.503      P=0.243      (e)          | 
|POLY 6             |     P=0.155N     P=0.294      P=0.523N     P=0.499N    |P=0.601N     P=0.498      P=0.249      (e)          | 
|LOGISTIC REGRESSION|     P=0.157N     P=0.290      (e)          (e)         |(e)          P=0.480      P=0.249      (e)          | 
|COCH-ARM / FISHERS |     P=0.155N     P=0.301      P=0.500N     P=0.505N    |P=0.612N     P=0.505      P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/49 (12%)   4/50 (8%)    5/49 (10%)  |5/49 (10%)   6/50 (12%)   2/49 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/48.41      6/47.13      4/44.90      5/48.55     |5/45.09      6/45.94      2/46.80      4/46.54      | 
|POLY-3 PERCENT (g) |     10.3%        12.7%        8.9%         10.3%       |11.1%        13.1%        4.3%         8.6%         | 
|TERMINAL (d)       |     5/47 (11%)   6/45 (13%)   4/39 (10%)   5/48 (10%)  |5/41 (12%)   5/37 (14%)   2/43 (5%)    4/43 (9%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      575          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488N     P=0.470      P=0.616N     P=0.617N    |P=0.273N     P=0.436      P=0.198N     P=0.470N     | 
|POLY 3             |     P=0.500N     P=0.481      P=0.547N     P=0.628N    |P=0.302N     P=0.513      P=0.201N     P=0.480N     | 
|POLY 1.5           |     P=0.499N     P=0.483      P=0.524N     P=0.629N    |P=0.308N     P=0.514      P=0.207N     P=0.486N     | 
|POLY 6             |     P=0.501N     P=0.478      P=0.573N     P=0.627N    |P=0.294N     P=0.507      P=0.196N     P=0.473N     | 
|LOGISTIC REGRESSION|     P=0.488N     P=0.470      P=0.616N     P=0.617N    |P=0.297N     P=0.506      P=0.198N     P=0.470N     | 
|COCH-ARM / FISHERS |     P=0.510N     P=0.486      P=0.500N     P=0.617     |P=0.311N     P=0.514      P=0.218N     P=0.487N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  31/50 (62%)  27/50 (54%)  22/50 (44%) |                                                    | 
|POLY-3 RATE (b)    |     29/48.41     31/49.00     27/48.26     22/49.55    |                                                    | 
|POLY-3 PERCENT (g) |     59.9%        63.3%        56.0%        44.4%       |                                                    | 
|TERMINAL (d)       |     29/47 (62%)  28/46 (61%)  20/39 (51%)  22/49 (45%) |                                                    | 
|FIRST INCIDENCE    |     728 (T)      594          498          728 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049N*    P=0.374      P=0.367      P=0.075N    |                                                    | 
|POLY 3             |     P=0.039N*    P=0.448      P=0.426N     P=0.090N    |                                                    | 
|POLY 1.5           |     P=0.040N*    P=0.434      P=0.412N     P=0.093N    |                                                    | 
|POLY 6             |     P=0.039N*    P=0.464      P=0.441N     P=0.088N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.046N*    P=0.409      P=0.453N     P=0.075N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.054N     P=0.419      P=0.420N     P=0.115N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Duct                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  27/50 (54%)  17/50 (34%)  13/50 (26%) |                                                    | 
|POLY-3 RATE (b)    |     20/48.49     27/49.00     17/47.65     13/50.00    |                                                    | 
|POLY-3 PERCENT (g) |     41.3%        55.1%        35.7%        26.0%       |                                                    | 
|TERMINAL (d)       |     19/47 (40%)  24/46 (52%)  11/39 (28%)  12/49 (25%) |                                                    | 
|FIRST INCIDENCE    |     708          594          498          596         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023N*    P=0.108      P=0.567      P=0.083N    |                                                    | 
|POLY 3             |     P=0.014N*    P=0.122      P=0.363N     P=0.082N    |                                                    | 
|POLY 1.5           |     P=0.014N*    P=0.117      P=0.346N     P=0.085N    |                                                    | 
|POLY 6             |     P=0.013N*    P=0.127      P=0.383N     P=0.079N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.020N*    P=0.110      P=0.342N     P=0.091N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.021N*    P=0.115      P=0.339N     P=0.101N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/48.49      0/48.13      1/44.51      0/49.55     |0/46.06      0/44.01      0/47.61      1/47.08      | 
|POLY-3 PERCENT (g) |     6.2%         0.0%         2.3%         0.0%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     2/47 (4%)    0/46 (0%)    1/39 (3%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     708          ---          728 (T)      ---         |---          ---          ---          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.091N     P=0.128N     P=0.377N     P=0.117N    |P=0.201      (e)          (e)          P=0.504      | 
|POLY 3             |     P=0.085N     P=0.120N     P=0.337N     P=0.115N    |P=0.205      (e)          (e)          P=0.504      | 
|POLY 1.5           |     P=0.085N     P=0.120N     P=0.325N     P=0.116N    |P=0.203      (e)          (e)          P=0.502      | 
|POLY 6             |     P=0.084N     P=0.122N     P=0.351N     P=0.115N    |P=0.208      (e)          (e)          P=0.508      | 
|LOGISTIC REGRESSION|     P=0.087N     P=0.121N     P=0.343N     P=0.118N    |P=0.255      (e)          (e)          P=0.560      | 
|COCH-ARM / FISHERS |     P=0.087N     P=0.121N     P=0.316N     P=0.121N    |P=0.201      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  33/50 (66%)  26/49 (53%)  29/50 (58%) |32/50 (64%)  27/48 (56%)  27/49 (55%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     31/48.41     33/48.44     26/44.62     29/49.55    |32/47.52     27/45.60     27/47.77     27/47.28     | 
|POLY-3 PERCENT (g) |     64.0%        68.1%        58.3%        58.5%       |67.3%        59.2%        56.5%        57.1%        | 
|TERMINAL (d)       |     31/47 (66%)  32/46 (70%)  25/39 (64%)  29/49 (59%) |28/41 (68%)  22/37 (60%)  26/44 (59%)  25/43 (58%)  | 
|FIRST INCIDENCE    |     728 (T)      644          702          728 (T)     |463          558          691          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203N     P=0.359      P=0.561      P=0.318N    |P=0.111N     P=0.405N     P=0.115N     P=0.148N     | 
|POLY 3             |     P=0.233N     P=0.417      P=0.359N     P=0.363N    |P=0.200N     P=0.272N     P=0.188N     P=0.205N     | 
|POLY 1.5           |     P=0.234N     P=0.415      P=0.296N     P=0.369N    |P=0.211N     P=0.277N     P=0.206N     P=0.215N     | 
|POLY 6             |     P=0.234N     P=0.415      P=0.441N     P=0.358N    |P=0.183N     P=0.273N     P=0.175N     P=0.190N     | 
|LOGISTIC REGRESSION|     P=0.228N     P=0.384      P=0.588N     P=0.318N    |P=0.180N     P=0.280N     P=0.154N     P=0.193N     | 
|COCH-ARM / FISHERS |     P=0.276N     P=0.418      P=0.243N     P=0.419N    |P=0.206N     P=0.282N     P=0.243N     P=0.208N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      2/44.99      0/49.55     |0/46.06      0/44.01      0/47.61      1/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    1/39 (3%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          588          ---         |---          ---          ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.598      (e)          P=0.210      (e)         |P=0.210      (e)          (e)          P=0.510      | 
|POLY 3             |     P=0.612      (e)          P=0.221      (e)         |P=0.203      (e)          (e)          P=0.502      | 
|POLY 1.5           |     P=0.609      (e)          P=0.227      (e)         |P=0.202      (e)          (e)          P=0.500      | 
|POLY 6             |     P=0.616      (e)          P=0.215      (e)         |P=0.206      (e)          (e)          P=0.504      | 
|LOGISTIC REGRESSION|     P=0.567      (e)          P=0.232      (e)         |(e)          (e)          (e)          P=0.510      | 
|COCH-ARM / FISHERS |     P=0.594      (e)          P=0.242      (e)         |P=0.201      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.41      1/48.24      2/45.73      0/49.55     |0/46.06      0/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          701          561          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.610N     P=0.496      P=0.221      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.606N     P=0.499      P=0.225      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.607N     P=0.500      P=0.231      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.605N     P=0.499      P=0.218      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.651      P=0.501      P=0.222      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.500      P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   10/50 (20%)  8/49 (16%)   5/50 (10%)  |16/49 (33%)  15/50 (30%)  9/50 (18%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     8/48.92      10/48.89     8/46.45      5/49.55     |16/47.49     15/47.80     9/48.13      11/48.91     | 
|POLY-3 PERCENT (g) |     16.4%        20.5%        17.2%        10.1%       |33.7%        31.4%        18.7%        22.5%        | 
|TERMINAL (d)       |     7/47 (15%)   8/46 (17%)   4/39 (10%)   5/49 (10%)  |10/41 (24%)  9/37 (24%)   8/44 (18%)   8/43 (19%)   | 
|FIRST INCIDENCE    |     572          594          365          728 (T)     |463          325          642          226          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167N     P=0.386      P=0.478      P=0.254N    |P=0.090N     P=0.568      P=0.071N     P=0.179N     | 
|POLY 3             |     P=0.165N     P=0.397      P=0.563      P=0.269N    |P=0.091N     P=0.491N     P=0.074N     P=0.159N     | 
|POLY 1.5           |     P=0.163N     P=0.397      P=0.581      P=0.268N    |P=0.094N     P=0.479N     P=0.073N     P=0.161N     | 
|POLY 6             |     P=0.168N     P=0.397      P=0.540      P=0.271N    |P=0.091N     P=0.516N     P=0.078N     P=0.164N     | 
|LOGISTIC REGRESSION|     P=0.192N     P=0.398      P=0.594N     P=0.280N    |P=0.101N     P=0.459N     P=0.090N     P=0.167N     | 
|COCH-ARM / FISHERS |     P=0.171N     P=0.398      P=0.590      P=0.277N    |P=0.099N     P=0.473N     P=0.074N     P=0.168N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/49 (2%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.49      1/49.13      1/44.99      1/50.00     |0/45.09      2/45.98      2/48.36      0/46.54      | 
|POLY-3 PERCENT (g) |     2.1%         2.0%         2.2%         2.0%        |0.0%         4.4%         4.1%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     708          50           588          596         |---          596          568          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.625N     P=0.756      P=0.727      P=0.753N    |P=0.484N     P=0.234      P=0.255      (e)          | 
|POLY 3             |     P=0.629N     P=0.757N     P=0.744      P=0.753N    |P=0.489N     P=0.242      P=0.253      (e)          | 
|POLY 1.5           |     P=0.630N     P=0.757N     P=0.750      P=0.755N    |P=0.493N     P=0.242      P=0.249      (e)          | 
|POLY 6             |     P=0.628N     P=0.759N     P=0.736      P=0.752N    |P=0.483N     P=0.240      P=0.258      (e)          | 
|LOGISTIC REGRESSION|     P=0.417      P=0.775N     P=0.759      P=0.724     |P=0.468N     P=0.248      P=0.195      (e)          | 
|COCH-ARM / FISHERS |     P=0.633      P=0.753N     P=0.747      P=0.753N    |P=0.495N     P=0.253      P=0.253      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |4/49 (8%)    1/50 (2%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      0/44.51      0/49.55     |4/45.09      1/45.42      0/47.80      4/47.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |8.9%         2.2%         0.0%         8.4%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |4/41 (10%)   1/37 (3%)    0/44 (0%)    3/43 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |733 (T)      733 (T)      ---          379          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.513      P=0.211N     P=0.055N     P=0.621N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.497      P=0.176N     P=0.053N     P=0.615N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.491      P=0.175N     P=0.055N     P=0.623N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.505      P=0.181N     P=0.052N     P=0.607N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.486      P=0.211N     (e)          P=0.629N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.484      P=0.175N     P=0.056N     P=0.631N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    3/48 (6%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.41      2/49.24      3/45.17      0/49.55     |1/46.82      1/45.44      2/48.30      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         6.6%         0.0%        |2.1%         2.2%         4.1%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          50           533          ---         |456          728          638          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.525N     P=0.237      P=0.113      (e)         |P=0.360N     P=0.750      P=0.513      P=0.508N     | 
|POLY 3             |     P=0.519N     P=0.241      P=0.107      (e)         |P=0.365N     P=0.754      P=0.511      P=0.501N     | 
|POLY 1.5           |     P=0.521N     P=0.241      P=0.110      (e)         |P=0.368N     P=0.757      P=0.506      P=0.502N     | 
|POLY 6             |     P=0.518N     P=0.241      P=0.104      (e)         |P=0.361N     P=0.750      P=0.517      P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.490      P=0.224      P=0.084      (e)         |P=0.324N     P=0.747N     P=0.375      P=0.344N     | 
|COCH-ARM / FISHERS |     P=0.532N     P=0.247      P=0.114      (e)         |P=0.366N     P=0.753N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      0/43.55      0/49.55     |0/46.06      0/45.42      0/47.80      2/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/41 (0%)    0/37 (0%)    0/44 (0%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.053      (e)          (e)          P=0.249      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.240      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.238      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.242      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/48.41      0/48.13      0/44.90      1/49.55     |2/46.06      1/45.42      1/47.80      3/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.0%        |4.3%         2.2%         2.1%         6.5%         | 
|TERMINAL (d)       |     0/47 (0%)    0/46 (0%)    0/39 (0%)    1/49 (2%)   |2/41 (5%)    1/37 (3%)    1/44 (2%)    3/43 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          728 (T)     |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      (e)          (e)          P=0.508     |P=0.359      P=0.536N     P=0.475N     P=0.522      | 
|POLY 3             |     P=0.202      (e)          (e)          P=0.505     |P=0.332      P=0.505N     P=0.487N     P=0.505      | 
|POLY 1.5           |     P=0.202      (e)          (e)          P=0.504     |P=0.328      P=0.502N     P=0.492N     P=0.501      | 
|POLY 6             |     P=0.203      (e)          (e)          P=0.505     |P=0.339      P=0.510N     P=0.482N     P=0.510      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.508     |P=0.359      P=0.536N     P=0.475N     P=0.522      | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.324      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/48.41      3/48.13      3/44.90      1/49.55     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         6.2%         6.7%         2.0%        |                                                    | 
|TERMINAL (d)       |     0/47 (0%)    3/46 (7%)    3/39 (8%)    1/49 (2%)   |                                                    | 
|FIRST INCIDENCE    |     ---          728 (T)      728 (T)      728 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.538      P=0.118      P=0.091      P=0.508     |                                                    | 
|POLY 3             |     P=0.543      P=0.118      P=0.106      P=0.505     |                                                    | 
|POLY 1.5           |     P=0.541      P=0.118      P=0.112      P=0.504     |                                                    | 
|POLY 6             |     P=0.544      P=0.117      P=0.099      P=0.505     |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.118      P=0.091      P=0.508     |                                                    | 
|COCH-ARM / FISHERS |     P=0.526      P=0.121      P=0.121      P=0.500     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/43 (5%)    3/44 (7%)    3/44 (7%)    1/49 (2%)   |2/47 (4%)    3/46 (7%)    2/47 (4%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     2/41.92      3/44.00      3/42.53      1/48.55     |2/44.05      3/42.28      2/45.16      1/43.74      | 
|POLY-3 PERCENT (g) |     4.8%         6.8%         7.1%         2.1%        |4.5%         7.1%         4.4%         2.3%         | 
|TERMINAL (d)       |     2/41 (5%)    0/41 (0%)    0/37 (0%)    1/48 (2%)   |0/39 (0%)    1/35 (3%)    0/41 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      50           498          728 (T)     |609          668          642          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.323N     P=0.500      P=0.470      P=0.445N    |P=0.296N     P=0.471      P=0.672N     P=0.492N     | 
|POLY 3             |     P=0.289N     P=0.522      P=0.507      P=0.449N    |P=0.311N     P=0.481      P=0.685N     P=0.502N     | 
|POLY 1.5           |     P=0.288N     P=0.521      P=0.512      P=0.448N    |P=0.313N     P=0.485      P=0.688N     P=0.503N     | 
|POLY 6             |     P=0.291N     P=0.523      P=0.499      P=0.450N    |P=0.309N     P=0.474      P=0.683N     P=0.502N     | 
|LOGISTIC REGRESSION|     P=0.474N     P=0.530      P=0.466      P=0.445N    |P=0.303N     P=0.501      P=0.655      P=0.491N     | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.511      P=0.511      P=0.451N    |P=0.310N     P=0.490      P=0.692N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.49      1/48.13      1/44.90      0/49.55     |2/46.19      0/44.99      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.2%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/47 (0%)    1/46 (2%)    1/39 (3%)    0/49 (0%)   |1/41 (2%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      728 (T)      ---         |698          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.585N     P=0.496      P=0.463      (e)         |P=0.110N     P=0.259N     P=0.227N     P=0.232N     | 
|POLY 3             |     P=0.587N     P=0.503      P=0.489      (e)         |P=0.112N     P=0.243N     P=0.230N     P=0.236N     | 
|POLY 1.5           |     P=0.586N     P=0.503      P=0.496      (e)         |P=0.112N     P=0.242N     P=0.233N     P=0.237N     | 
|POLY 6             |     P=0.587N     P=0.501      P=0.480      (e)         |P=0.111N     P=0.246N     P=0.227N     P=0.234N     | 
|LOGISTIC REGRESSION|     (e)          P=0.496      P=0.463      (e)         |P=0.114N     P=0.242N     P=0.235N     P=0.237N     | 
|COCH-ARM / FISHERS |     P=0.592N     P=0.505      P=0.505      (e)         |P=0.115N     P=0.253N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    4/50 (8%)    5/50 (10%)   5/50 (10%)  |3/50 (6%)    4/49 (8%)    10/50 (20%)  4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/47.49      4/48.13      5/45.01      5/49.55     |3/46.06      4/44.99      10/47.80     4/46.54      | 
|POLY-3 PERCENT (g) |     8.4%         8.3%         11.1%        10.1%       |6.5%         8.9%         20.9%        8.6%         | 
|TERMINAL (d)       |     4/47 (9%)    4/46 (9%)    4/39 (10%)   5/49 (10%)  |3/41 (7%)    4/37 (11%)   10/44 (23%)  4/43 (9%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      702          728 (T)     |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.632      P=0.387      P=0.526     |P=0.426      P=0.444      P=0.048 *    P=0.526      | 
|POLY 3             |     P=0.426      P=0.635N     P=0.467      P=0.526     |P=0.378      P=0.487      P=0.041 *    P=0.506      | 
|POLY 1.5           |     P=0.426      P=0.634N     P=0.489      P=0.525     |P=0.368      P=0.489      P=0.039 *    P=0.501      | 
|POLY 6             |     P=0.426      P=0.639N     P=0.441      P=0.527     |P=0.392      P=0.482      P=0.043 *    P=0.512      | 
|LOGISTIC REGRESSION|     P=0.422      P=0.632      P=0.427      P=0.526     |P=0.426      P=0.444      P=0.048 *    P=0.526      | 
|COCH-ARM / FISHERS |     P=0.411      P=0.631N     P=0.513      P=0.513     |P=0.368      P=0.489      P=0.036 *    P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   0/0 (0%)     1/1 (100%)   2/2 (100%)  |1/2 (50%)    0/0 (0%)     1/1 (100%)   1/1 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       0/0.00       1/1.00       2/2.00      |1/2.00       0/0.00       1/1.00       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       100.0%      |50.0%        0.0%         100.0%       100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     0/0 (0%)     2/2 (100%)  |1/2 (50%)    0/0 (0%)     1/1 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     728 (T)      ---          365          728 (T)     |733 (T)      ---          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.382      P=1.000      P=0.638      P=0.638      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.614      P=0.614      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.614      P=0.614      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.614      P=0.614      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.382      (e)          P=0.638      P=0.638      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.364      P=1.000      P=0.667      P=0.667      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  20/50 (40%)  18/50 (36%)  21/50 (42%) |33/50 (66%)  39/50 (78%)  33/50 (66%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     16/48.41     20/48.13     18/46.06     21/50.00    |33/47.37     39/47.39     33/48.83     33/47.65     | 
|POLY-3 PERCENT (g) |     33.1%        41.6%        39.1%        42.0%       |69.7%        82.3%        67.6%        69.3%        | 
|TERMINAL (d)       |     16/47 (34%)  20/46 (44%)  16/39 (41%)  20/49 (41%) |30/41 (73%)  32/37 (87%)  30/44 (68%)  30/43 (70%)  | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      365          596         |463          551          568          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268      P=0.237      P=0.196      P=0.254     |P=0.167N     P=0.041 *    P=0.400N     P=0.461N     | 
|POLY 3             |     P=0.260      P=0.258      P=0.347      P=0.241     |P=0.319N     P=0.107      P=0.500N     P=0.571N     | 
|POLY 1.5           |     P=0.255      P=0.261      P=0.385      P=0.234     |P=0.351N     P=0.114      P=0.535N     P=0.581      | 
|POLY 6             |     P=0.268      P=0.251      P=0.301      P=0.249     |P=0.272N     P=0.099      P=0.461N     P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.243      P=0.237      P=0.355      P=0.223     |P=0.319N     P=0.111      P=0.504N     P=0.571N     | 
|COCH-ARM / FISHERS |     P=0.222      P=0.266      P=0.417      P=0.204     |P=0.358N     P=0.133      P=0.583N     P=0.583N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |7/50 (14%)   3/50 (6%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |7/46.47      3/45.64      2/47.80      6/46.54      | 
|POLY-3 PERCENT (g) |                                                        |15.1%        6.6%         4.2%         12.9%        | 
|TERMINAL (d)       |                                                        |6/41 (15%)   2/37 (5%)    2/44 (5%)    6/43 (14%)   | 
|FIRST INCIDENCE    |                                                        |614          673          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.477N     P=0.201N     P=0.067N     P=0.465N     | 
|POLY 3             |                                                        |P=0.524N     P=0.165N     P=0.072N     P=0.499N     | 
|POLY 1.5           |                                                        |P=0.530N     P=0.162N     P=0.075N     P=0.503N     | 
|POLY 6             |                                                        |P=0.516N     P=0.171N     P=0.071N     P=0.494N     | 
|LOGISTIC REGRESSION|                                                        |P=0.520N     P=0.162N     P=0.075N     P=0.491N     | 
|COCH-ARM / FISHERS |                                                        |P=0.533N     P=0.159N     P=0.080N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |42/50 (84%)  46/50 (92%)  41/50 (82%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |                                                        |42/48.12     46/48.70     41/48.36     48/49.80     | 
|POLY-3 PERCENT (g) |                                                        |87.3%        94.5%        84.8%        96.4%        | 
|TERMINAL (d)       |                                                        |38/41 (93%)  37/37 (100%) 39/44 (89%)  42/43 (98%)  | 
|FIRST INCIDENCE    |                                                        |463          325          568          226          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.446      P=0.040 *    P=0.220N     P=0.206      | 
|POLY 3             |                                                        |P=0.133      P=0.171      P=0.474N     P=0.086      | 
|POLY 1.5           |                                                        |P=0.107      P=0.176      P=0.486N     P=0.065      | 
|POLY 6             |                                                        |P=0.175      P=0.160      P=0.461N     P=0.117      | 
|LOGISTIC REGRESSION|                                                        |P=0.073      P=0.160      P=0.357N     P=0.041 *    | 
|COCH-ARM / FISHERS |                                                        |P=0.083      P=0.178      P=0.500N     P=0.046 *    | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).