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TDMS Study 56348-03 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                       CITRAL                                                 DATE: 07/05/01  
EXPERIMENT: 56348 TEST: 03                                                                                        TIME: 13:00:49    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56348      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS LABORATORY                     CITRAL                                                      DATE: 07/05/01    
EXPERIMENT: 56348 TEST: 03                                                                                        TIME: 13:23:06    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56348      
CONT: N01-ES-55384                                                                                                CAS: 5392-40-5    
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                                   CHRONIC DOSED FEED STUDY OF CITRAL                                               
==================================================================================================================================  
      UNTREAT CONTROL             VEHICLE CONTROL                        1000 PPM                           2000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    17.3   124.4      16.8    125.8    0.97        0     17.2    126.0    0.99      426     17.1    124.6    0.99      857       
  2    20.3   162.0      20.4    161.2    1.00        0     20.4    162.8    1.00      391     20.1    159.6    0.99      786       
  5    22.3   267.4      20.9    265.5    0.94        0     20.4    262.4    0.91      243     20.6    260.3    0.92      494       
  9    19.9   330.0      20.3    330.3    1.02        0     20.1    326.7    1.01      192     19.9    319.4    1.00      390       
 13    19.4   362.5      19.6    363.3    1.01        0     19.5    362.3    1.01      168     19.1    353.6    0.98      338       
 17    20.1   390.9      19.4    389.5    0.97        0     19.9    389.8    0.99      159     19.7    380.7    0.98      323       
 21    19.0   408.6      19.7    409.6    1.04        0     19.6    406.2    1.03      150     19.8    399.9    1.04      310       
 25    21.0   426.9      21.2    423.8    1.01        0     20.8    421.3    0.99      154     20.2    411.8    0.96      306       
 29    19.1   433.7      18.8    435.0    0.98        0     19.2    425.5    1.01      140     19.6    419.6    1.03      293       
 33    19.8   442.3      20.1    438.9    1.02        0     20.5    437.6    1.04      146     20.1    431.5    1.02      291       
 37    20.0   455.4      19.9    453.4    1.00        0     20.0    450.7    1.00      138     19.4    443.7    0.97      274       
 41    20.6   463.2      20.2    462.3    0.98        0     19.9    458.0    0.97      135     20.1    451.7    0.98      278       
 45    21.4   471.8      21.2    468.6    0.99        0     21.8    464.4    1.02      146     20.8    458.3    0.97      284       
 49    20.0   479.7      19.4    478.7    0.97        0     19.3    472.6    0.97      127     19.3    464.9    0.97      259       
 53    19.3   485.9      19.2    487.2    0.99        0     19.0    478.6    0.98      124     18.9    472.1    0.98      251       
 57    19.8   487.1      19.3    482.7    0.97        0     20.1    476.8    1.02      132     19.5    472.1    0.98      258       
 61    19.1   489.7      19.6    489.7    1.03        0     19.2    482.5    1.01      124     19.3    478.3    1.01      252       
 65    18.9   492.7      19.4    489.7    1.03        0     19.1    484.2    1.01      123     18.9    481.9    1.00      245       
 69    19.6   488.5      19.4    486.0    0.99        0     19.2    479.4    0.98      125     19.1    477.6    0.97      249       
 73    18.0   483.6      18.2    479.5    1.01        0     17.6    474.9    0.98      116     17.6    473.7    0.98      233       
 77    17.7   486.4      18.2    489.8    1.03        0     18.3    480.3    1.03      119     17.2    476.3    0.97      226       
 81    16.8   478.5      17.4    485.6    1.04        0     17.2    479.7    1.02      112     16.2    471.9    0.96      214       
 85    17.2   482.9      16.6    484.7    0.97        0     16.7    479.1    0.97      109     17.2    477.6    1.00      225       
 89    16.7   484.3      16.2    477.9    0.97        0     17.6    481.3    1.05      114     16.8    473.9    1.01      221       
 93    16.6   473.2      16.1    466.4    0.97        0     16.5    474.7    0.99      109     16.8    469.4    1.01      224       
 97    16.1   482.4      15.9    473.2    0.99        0     16.4    474.7    1.02      108     16.7    467.1    1.04      224       
101    16.9   475.8      17.0    478.7    1.01        0     16.2    470.1    0.96      108     16.3    461.2    0.96      221       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   19.8   249.3      19.6    249.2    0.99        0     19.5    248.0    0.99      284     19.4    243.5    0.98      573       
SD(D)   1.8               1.6             0.03        0      1.3             0.04      118      1.4             0.03      235       
CV(E)   9.2               8.3             3.5                6.9             4.1      41.4      7.1             3.1      41.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   20.1   441.4      20.0    440.0    0.99        0     20.1    436.2    1.00      144     19.9    429.1    0.99      291       
SD(D)   0.8               0.8             0.02        0      0.8             0.03       10      0.5             0.03       20       
CV(E)   4.0               4.0             2.3                4.1             2.5       6.9      2.3             3.0       6.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   17.9   483.9      17.9    482.4    1.00        0     17.9    478.2    1.00      117     17.7    473.3    0.99      234       
SD(D)   1.3               1.4             0.03        0      1.3             0.03        8      1.2             0.02       15       
CV(E)   7.3               8.0             2.5                7.3             2.7       6.8      6.8             2.2       6.3       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                                                   
       CHRONIC DOSED FEED STUDY OF CITRAL                                                                                           
==========================================                                                                                          
                    4000 PPM                                                                                                        
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1    17.0    125.9     0.98    1691                                                                                               
  2    20.3    156.5     1.00    1625                                                                                               
  5    24.2    257.8     1.09    1174                                                                                               
  9    22.5    315.4     1.13     891                                                                                               
 13    21.8    349.0     1.12     781                                                                                               
 17    21.4    375.9     1.06     711                                                                                               
 21    20.1    392.0     1.06     641                                                                                               
 25    20.1    399.3     0.96     629                                                                                               
 29    20.1    412.7     1.05     608                                                                                               
 33    19.4    419.9     0.98     577                                                                                               
 37    19.7    430.3     0.99     573                                                                                               
 41    20.2    435.9     0.98     579                                                                                               
 45    22.4    445.4     1.05     627                                                                                               
 49    19.6    449.7     0.98     545                                                                                               
 53    18.7    455.8     0.97     513                                                                                               
 57    19.5    448.1     0.98     543                                                                                               
 61    20.3    458.1     1.06     554                                                                                               
 65    19.2    459.8     1.02     522                                                                                               
 69    19.3    456.1     0.98     529                                                                                               
 73    18.2    453.0     1.01     502                                                                                               
 77    18.7    456.0     1.06     512                                                                                               
 81    17.5    454.5     1.04     480                                                                                               
 85    17.1    453.2     0.99     472                                                                                               
 89    17.9    451.7     1.07     495                                                                                               
 93    17.3    447.7     1.04     483                                                                                               
 97    17.3    451.6     1.07     479                                                                                               
101    17.0    439.8     1.01     484                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   21.2    240.9     1.06    1232                                                                                               
SD(D)   2.7              0.07     415                                                                                               
CV(E)  12.8              6.5     33.7                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   20.3    417.9     1.01     610                                                                                               
SD(D)   0.9              0.04      49                                                                                               
CV(E)   4.7              4.2      8.1                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   18.3    452.7     1.02     505                                                                                               
SD(D)   1.1              0.04      26                                                                                               
CV(E)   5.8              3.5      5.2                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                                   CHRONIC DOSED FEED STUDY OF CITRAL                                               
==================================================================================================================================  
      UNTREAT CONTROL             VEHICLE CONTROL                        1000 PPM                           2000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    13.3   106.7      13.3    106.2     1.00       0     13.1    106.9     0.98     382     12.9    107.4     0.97     748       
  2    12.3   125.4      12.4    125.0     1.01       0     12.2    123.7     0.99     309     12.2    124.4     0.99     612       
  5    13.5   165.7      13.4    166.0     0.99       0     12.6    162.0     0.93     243     12.5    161.9     0.93     483       
  9    12.3   186.9      12.6    186.9     1.02       0     12.5    185.8     1.02     210     12.4    184.5     1.01     420       
 13    12.0   197.5      12.3    200.5     1.03       0     11.7    196.4     0.98     186     12.0    197.5     1.00     379       
 17    12.3   207.0      12.2    208.4     0.99       0     11.4    203.4     0.93     175     11.6    204.0     0.94     354       
 21    11.4   212.7      11.2    213.4     0.98       0     11.2    209.7     0.98     167     11.4    211.6     1.00     337       
 25    12.6   218.6      12.5    219.0     0.99       0     11.8    213.9     0.94     172     11.6    215.3     0.92     338       
 29    14.2   231.3      12.8    226.2     0.90       0     12.2    222.9     0.86     170     12.1    223.8     0.85     339       
 33    11.9   229.7      12.4    230.2     1.04       0     11.9    225.8     1.00     164     11.6    226.1     0.97     322       
 37    12.5   236.4      12.4    238.2     0.99       0     11.8    232.3     0.94     159     11.8    232.2     0.94     318       
 41    12.7   240.4      12.8    241.9     1.01       0     12.1    236.5     0.95     160     12.0    235.4     0.94     320       
 45    13.0   249.8      13.4    252.9     1.03       0     12.9    245.1     0.99     164     12.7    244.0     0.98     325       
 49    12.9   257.4      13.0    258.8     1.01       0     12.8    251.9     0.99     158     12.7    251.5     0.98     317       
 53    13.0   267.7      13.6    269.6     1.05       0     12.7    259.5     0.98     153     12.5    257.4     0.96     303       
 57    13.1   274.1      12.8    275.9     0.98       0     12.0    267.5     0.92     141     12.3    264.4     0.94     290       
 61    13.8   280.7      14.2    286.3     1.03       0     13.4    275.1     0.97     152     13.4    273.5     0.97     306       
 65    13.4   286.4      13.5    290.0     1.01       0     13.5    282.6     1.01     149     13.0    281.5     0.97     289       
 69    13.5   298.3      13.8    301.6     1.02       0     13.1    291.0     0.97     141     13.3    290.8     0.99     286       
 73    12.7   306.6      13.2    309.3     1.04       0     12.3    298.0     0.97     129     12.1    295.8     0.95     256       
 77    12.4   313.8      13.0    317.7     1.05       0     13.2    306.8     1.06     134     12.8    305.3     1.03     262       
 81    12.6   320.1      13.1    326.8     1.04       0     12.3    313.3     0.98     122     12.5    311.1     0.99     251       
 85    13.0   327.2      13.0    332.4     1.00       0     12.1    319.4     0.93     118     12.6    317.6     0.97     249       
 89    12.2   325.2      13.0    334.0     1.07       0     12.8    324.0     1.05     123     12.8    321.6     1.05     249       
 93    13.3   329.1      12.8    331.7     0.96       0     12.5    324.2     0.94     120     12.6    322.2     0.95     245       
 97    13.2   333.5      12.8    331.0     0.97       0     12.0    322.1     0.91     116     12.4    322.5     0.94     240       
101    12.9   334.8      13.1    335.2     1.02       0     12.9    326.1     1.00     123     12.6    322.6     0.98     244       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   12.7   156.4      12.8    156.9     1.01       0     12.4    154.9     0.98     266     12.4    155.1     0.98     529       
SD(D)   0.6               0.5              0.01       0      0.5              0.03      80      0.3              0.03     151       
CV(E)   5.1               4.1              1.4               4.1              3.1     30.0      2.7              3.4     28.6       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   12.6   231.5      12.5    232.1     0.99       0     12.0    226.8     0.95     166     12.0    227.1     0.95     330       
SD(D)   0.8               0.6              0.04       0      0.5              0.04       6      0.5              0.04      13       
CV(E)   6.1               4.9              4.0               4.5              4.7      3.7      4.1              4.6      3.9       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   13.0   307.5      13.2    310.9     1.02       0     12.7    300.7     0.98     132     12.7    298.9     0.98     267       
SD(D)   0.5               0.4              0.03       0      0.5              0.05      13      0.4              0.03      24       
CV(E)   3.5               3.2              3.2               4.1              4.8     10.0      3.0              3.4      9.1       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                                                 
       CHRONIC DOSED FEED STUDY OF CITRAL                                                                                           
==========================================                                                                                          
                    4000 PPM                                                                                                        
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1    13.2    108.2     0.99    1522                                                                                               
  2    12.7    122.4     1.03    1293                                                                                               
  5    13.3    159.0     0.99    1043                                                                                               
  9    12.8    177.9     1.04     901                                                                                               
 13    11.8    190.1     0.98     779                                                                                               
 17    11.8    198.2     0.96     746                                                                                               
 21    11.4    202.7     1.00     705                                                                                               
 25    11.7    206.8     0.93     710                                                                                               
 29    11.8    211.1     0.83     701                                                                                               
 33    11.7    215.9     0.98     680                                                                                               
 37    11.6    220.5     0.93     659                                                                                               
 41    11.8    221.8     0.93     665                                                                                               
 45    13.1    229.1     1.01     713                                                                                               
 49    12.3    234.8     0.95     655                                                                                               
 53    11.8    235.5     0.91     625                                                                                               
 57    12.4    240.3     0.95     646                                                                                               
 61    12.3    246.4     0.89     623                                                                                               
 65    12.5    253.4     0.93     615                                                                                               
 69    14.1    262.5     1.04     670                                                                                               
 73    12.5    265.8     0.98     587                                                                                               
 77    13.3    274.7     1.07     603                                                                                               
 81    12.1    281.8     0.96     535                                                                                               
 85    12.4    285.8     0.95     542                                                                                               
 89    13.0    290.7     1.07     558                                                                                               
 93    12.9    291.4     0.97     554                                                                                               
 97    12.3    289.3     0.93     529                                                                                               
101    13.5    298.2     1.05     565                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   12.8    151.5     1.01    1108                                                                                               
SD(D)   0.6              0.03     300                                                                                               
CV(E)   4.4              2.7     27.1                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   11.9    215.6     0.95     693                                                                                               
SD(D)   0.5              0.05      30                                                                                               
CV(E)   4.1              5.6      4.4                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   12.7    270.5     0.98     589                                                                                               
SD(D)   0.6              0.06      45                                                                                               
CV(E)   5.0              6.2      7.7                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                                  DIAGNOSTIC TRAILER REPORT                                                         
                                                  FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                 
                                                  CHRONIC DOSED FEED STUDY OF CITRAL                                                
==================================================================================================================================  
      UNTREAT CONTROL          VEHICLE CONTROL              1000 PPM                 2000 PPM                 4000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B              124.4  50                125.8  50                126.0  50                124.6  50                125.9  50      
  1  17.3  4800  124.4  50    16.8  4783  125.8  50    17.2  4784  126.0  50    17.1  4788  124.6  50    17.0  4784  125.9  50      
  2  20.3  3350  162.0  50    20.4  3364  161.2  50    20.4  3380  162.8  50    20.1  3395  159.6  50    20.3  3567  156.5  50      
  5  22.3  8273  267.4  50    20.9  8386  265.5  50    20.4  8410  262.4  50    20.6  8430  260.3  50    24.2  8460  257.8  50      
  9  19.9  8449  330.0  50    20.3  8485  330.3  50    20.1  8535  326.7  50    19.9  8521  319.4  50    22.5  8438  315.4  50      
 13  19.4  8623  362.5  50    19.6  8588  363.3  50    19.5  8603  362.3  50    19.1  8496  353.6  50    21.8  8309  349.0  50      
 17  20.1  8309  390.9  50    19.4  8244  389.5  50    19.9  8250  389.8  50    19.7  8209  380.7  50    21.4  8200  375.9  50      
 21  19.0  8419  408.6  50    19.7  8382  409.6  50    19.6  8367  406.2  50    19.8  8360  399.9  50    20.1  8314  392.0  50      
 25  21.0  8449  426.9  50    21.2  8491  423.8  50    20.8  8508  421.3  50    20.2  8568  411.8  50    20.1  8608  399.3  50      
 29  19.1  8383  433.7  50    18.8  8435  435.0  50    19.2  8257  425.5  50    19.6  8485  419.6  50    20.1  8500  412.7  50      
 33  19.8  8335  442.3  50    20.1  8347  438.9  50    20.5  8363  437.6  50    20.1  8376  431.5  50    19.4  8413  419.9  50      
 37  20.0  8322  455.4  50    19.9  7747  453.4  50    20.0  8137  450.7  50    19.4  8313  443.7  50    19.7  7871  430.3  50      
 41  20.6  7880  463.2  50    20.2  8174  462.3  50    19.9  8465  458.0  50    20.1  8274  451.7  50    20.2  8256  435.9  50      
 45  21.4  8436  471.8  50    21.2  8130  468.6  50    21.8  8140  464.4  50    20.8  8233  458.3  50    22.4  6350  445.4  50      
 49  20.0  7743  479.7  50    19.4  8059  478.7  50    19.3  8369  472.6  50    19.3  7880  464.9  50    19.6  7962  449.7  50      
 53  19.3  8266  485.9  50    19.2  8332  487.2  49    19.0  8480  478.6  50    18.9  8517  472.1  50    18.7  8323  455.8  50      
 57  19.8  8423  487.1  50    19.3  8052  482.7  49    20.1  8498  476.8  50    19.5  8463  472.1  50    19.5  7861  448.1  50      
 61  19.1  8365  489.7  50    19.6  7999  489.7  49    19.2  8397  482.5  50    19.3  8385  478.3  50    20.3  7998  458.1  49      
 65  18.9  8327  492.7  49    19.4  8066  489.7  48    19.1  8422  484.2  50    18.9  8449  481.9  50    19.2  8302  459.8  49      
 69  19.6  8141  488.5  49    19.4  7991  486.0  48    19.2  8059  479.4  49    19.1  8362  477.6  50    19.3  8213  456.1  49      
 73  18.0  8243  483.6  48    18.2  8205  479.5  48    17.6  8242  474.9  48    17.6  8544  473.7  50    18.2  8395  453.0  49      
 77  17.7  8040  486.4  48    18.2  7641  489.8  46    18.3  7960  480.3  47    17.2  8489  476.3  50    18.7  8180  456.0  48      
 81  16.8  7419  478.5  47    17.4  7452  485.6  46    17.2  7995  479.7  47    16.2  8545  471.9  50    17.5  8060  454.5  47      
 85  17.2  7565  482.9  46    16.6  7783  484.7  46    16.7  7988  479.1  47    17.2  8342  477.6  49    17.1  7882  453.2  47      
 89  16.7  7194  484.3  42    16.2  7232  477.9  44    17.6  7996  481.3  47    16.8  8184  473.9  48    17.9  7635  451.7  46      
 93  16.6  6789  473.2  40    16.1  6460  466.4  38    16.5  7657  474.7  45    16.8  7848  469.4  46    17.3  6989  447.7  43      
 97  16.1  5923  482.4  34    15.9  5345  473.2  31    16.4  7105  474.7  42    16.7  7432  467.1  44    17.3  6338  451.6  41      
101  16.9  5193  475.8  31    17.0  4193  478.7  25    16.2  6218  470.1  37    16.3  7136  461.2  42    17.0  6047  439.8  38      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          249.3                    249.2                    248.0                    243.5                    240.9          
14 TO 52         441.4                    440.0                    436.2                    429.1                    417.9          
 > 52            483.9                    482.4                    478.2                    473.3                    452.7          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                                  DIAGNOSTIC TRAILER REPORT                                                         
                                                  FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                               
                                                  CHRONIC DOSED FEED STUDY OF CITRAL                                                
==================================================================================================================================  
      UNTREAT CONTROL          VEHICLE CONTROL              1000 PPM                 2000 PPM                 4000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B              106.7  50                106.2  50                106.9  50                107.4  50                108.2  50      
  1  13.3  4519  106.7  50    13.3  4513  106.2  50    13.1  4520  106.9  50    12.9  4525  107.4  50    13.2  4531  108.2  50      
  2  12.3  3617  125.4  50    12.4  3632  125.0  50    12.2  3641  123.7  50    12.2  3647  124.4  50    12.7  3696  122.4  50      
  5  13.5  8399  165.7  50    13.4  8429  166.0  50    12.6  8427  162.0  50    12.5  8527  161.9  50    13.3  8550  159.0  50      
  9  12.3  8283  186.9  50    12.6  8316  186.9  50    12.5  8386  185.8  50    12.4  8488  184.5  50    12.8  8485  177.9  50      
 13  12.0  8456  197.5  50    12.3  8298  200.5  49    11.7  8522  196.4  50    12.0  8536  197.5  50    11.8  8624  190.1  50      
 17  12.3  8368  207.0  50    12.2  8220  208.4  49    11.4  8459  203.4  50    11.6  8520  204.0  50    11.8  8530  198.2  50      
 21  11.4  8360  212.7  50    11.2  8222  213.4  49    11.2  8431  209.7  50    11.4  8479  211.6  50    11.4  8490  202.7  50      
 25  12.6  8531  218.6  50    12.5  8411  219.0  49    11.8  8630  213.9  50    11.6  8635  215.3  50    11.7  8648  206.8  50      
 29  14.2  7366  231.3  50    12.8  8106  226.2  49    12.2  8282  222.9  50    12.1  8296  223.8  50    11.8  8311  211.1  50      
 33  11.9  8482  229.7  50    12.4  8228  230.2  49    11.9  8414  225.8  50    11.6  8425  226.1  50    11.7  8441  215.9  50      
 37  12.5  8516  236.4  50    12.4  8314  238.2  49    11.8  8490  232.3  50    11.8  8486  232.2  50    11.6  8395  220.5  50      
 41  12.7  8497  240.4  50    12.8  8368  241.9  49    12.1  8527  236.5  50    12.0  8534  235.4  50    11.8  8170  221.8  50      
 45  13.0  8472  249.8  50    13.4  8287  252.9  49    12.9  8480  245.1  50    12.7  8463  244.0  50    13.1  8420  229.1  50      
 49  12.9  8467  257.4  50    13.0  8270  258.8  49    12.8  8410  251.9  50    12.7  8407  251.5  50    12.3  8333  234.8  50      
 53  13.0  8413  267.7  50    13.6  8255  269.6  49    12.7  8441  259.5  50    12.5  8615  257.4  50    11.8  8618  235.5  50      
 57  13.1  8332  274.1  50    12.8  8183  275.9  49    12.0  8411  267.5  50    12.3  8428  264.4  50    12.4  8276  240.3  49      
 61  13.8  7863  280.7  50    14.2  8184  286.3  49    13.4  8209  275.1  49    13.4  8390  273.5  50    12.3  8241  246.4  49      
 65  13.4  8145  286.4  50    13.5  7603  290.0  49    13.5  8372  282.6  49    13.0  8363  281.5  48    12.5  8152  253.4  48      
 69  13.5  8308  298.3  50    13.8  8165  301.6  49    13.1  8177  291.0  49    13.3  8025  290.8  48    14.1  7873  262.5  47      
 73  12.7  8478  306.6  49    13.2  8167  309.3  48    12.3  8350  298.0  49    12.1  8076  295.8  47    12.5  7861  265.8  46      
 77  12.4  8187  313.8  48    13.0  8208  317.7  48    13.2  8151  306.8  48    12.8  7827  305.3  46    13.3  7667  274.7  45      
 81  12.6  8067  320.1  48    13.1  8075  326.8  48    12.3  8101  313.3  48    12.5  7696  311.1  46    12.1  7509  281.8  45      
 85  13.0  7958  327.2  47    13.0  8095  332.4  48    12.1  7939  319.4  47    12.6  7767  317.6  46    12.4  7478  285.8  44      
 89  12.2  7566  325.2  45    13.0  8089  334.0  48    12.8  7594  324.0  45    12.8  7601  321.6  45    13.0  7252  290.7  42      
 93  13.3  6891  329.1  41    12.8  7241  331.7  48    12.5  7501  324.2  44    12.6  7435  322.2  43    12.9  7110  291.4  42      
 97  13.2  6692  333.5  40    12.8  7890  331.0  47    12.0  7066  322.1  42    12.4  7147  322.5  42    12.3  7100  289.3  42      
101  12.9  6542  334.8  39    13.1  7227  335.2  43    12.9  6734  326.1  40    12.6  6578  322.6  39    13.5  6205  298.2  38      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          156.4                    156.9                    154.9                    155.1                    151.5          
14 TO 52         231.5                    232.1                    226.8                    227.1                    215.6          
 > 52            307.5                    310.9                    300.7                    298.9                    270.5          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.