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TDMS Study 56348-03 Pathology Tables

NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01
Route: DOSED FEED                                                                                                 Time: 15:28:02




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  5392-40-5

       Lock Date:  03/25/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           10           11           11           12                        
    Natural Death                                      3                         3            3            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           40           36           36           36                        
    Natural Death                                      1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Polyp Adenomatous                                1 (2%)                                 1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)         (50)                      
      Sarcoma                                                       1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Mesentery                                          (10)         (5)          (1)          (5)          (7)                       
   Oral Mucosa                                                                  (1)                                                 
      Pharyngeal, Squamous Cell Papilloma                                        1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
   Salivary Glands                                    (50)         (50)         (50)         (50)         (50)                      
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
   Tongue                                                          (1)                                    (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Schwannoma Malignant                             1 (2%)                    1 (2%)       2 (4%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (50)         (50)         (50)                      
      Pheochromocytoma Benign                          2 (4%)       1 (2%)       1 (2%)       2 (4%)       1 (2%)                   
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (49)                      
      Adenoma                                                                                 2 (4%)       1 (2%)                   
   Parathyroid Gland                                  (43)         (43)         (40)         (43)         (47)                      
      Adenoma                                          2 (5%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (49)                      
      Pars Distalis, Adenoma                          12 (24%)     17 (34%)     11 (22%)     17 (34%)     13 (27%)                  
      Pars Distalis, Carcinoma                                                                1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (2%)                                
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  7 (14%)     13 (26%)      9 (18%)      9 (18%)     11 (22%)                  
      C-Cell, Carcinoma                                                          2 (4%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (49)         (49)         (50)         (49)                      
      Adenoma                                          9 (18%)      5 (10%)      2 (4%)       4 (8%)       1 (2%)                   
      Carcinoma                                                     1 (2%)                                                          
      Bilateral, Adenoma                                            1 (2%)       1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)         (50)                      
   Uterus                                             (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                       1 (2%)                                                          
      Fibroma                                                                                 1 (2%)                                
      Hemangioma                                                    1 (2%)                                                          
      Polyp Stromal                                   13 (26%)      4 (8%)       8 (16%)      8 (16%)     10 (20%)                  
      Polyp Stromal, Multiple                                       1 (2%)                                                          
      Schwannoma Malignant                                                                    1 (2%)                                
      Cervix, Leiomyosarcoma                                                                  1 (2%)                                
      Cervix, Polyp Stromal                            1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Vagina                                                          (2)          (1)          (2)                                    
      Schwannoma Malignant, Metastatic, Skin                                                  1 (50%)                               
      Schwannoma Malignant, Metastatic, Uterus                                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
   Lymph Node                                         (7)          (4)          (7)          (10)         (5)                       
      Mediastinal, Carcinoma, Metastatic, Mammary                                                                                   
          Gland                                                                               1 (10%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)         (50)                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)         (50)                      
   Spleen                                             (50)         (50)         (50)         (50)         (50)                      
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Thymus                                             (49)         (47)         (49)         (48)         (49)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Carcinoma                                                                  1 (2%)       3 (6%)                                
      Fibroadenoma                                    22 (44%)     21 (42%)     16 (32%)     18 (36%)     15 (30%)                  
      Fibroadenoma, Multiple                           4 (8%)       6 (12%)      6 (12%)                   1 (2%)                   
      Hemangioma                                                    1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                                                                      2 (4%)                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Subcutaneous Tissue, Lipoma                      2 (4%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                                                           (1)                                    
      Schwannoma Malignant, Metastatic, Skin                                                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
      Meningioma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)       1 (2%)       1 (2%)                   
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland                                                    1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       2 (4%)                                             
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
      Mediastinum, Carcinoma, Metastatic, Mammary                                                                                   
          Gland                                                                               1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (1)                       (2)                       
      Retrobulbar, Schwannoma Malignant                                                                    1 (50%)                  
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Renal Tubule, Adenoma                                         1 (2%)                                                          
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Leukemia Mononuclear                            14 (28%)     10 (20%)     22 (44%)     14 (28%)     15 (30%)                  
      Lymphoma Malignant                               1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          45          47          46          43                           
     Total Primary Neoplasms                           95          96          88          93          75                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          41          39          37          38                           
     Total Benign Neoplasms                            79          80          60          67          57                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          15          26          22          17                           
     Total Malignant Neoplasms                         16          16          28          26          18                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           2           6                                       
     Total Metastatic Neoplasm                                      1           2          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           22           15           11           10                        
    Natural Death                                      2            6            3            4            6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           22           32           35           34                        
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Carcinoma                                        1 (2%)                                                                       
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)         (50)                      
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                                                       1 (2%)                   
   Intestine Small, Ileum                             (50)         (50)         (49)         (50)         (50)                      
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Mesentery                                          (8)          (13)         (11)         (11)         (5)                       
      Fibrosarcoma                                                                                         1 (20%)                  
      Fibrous Histiocytoma, Metastatic, Skin                        1 (8%)                                                          
   Oral Mucosa                                                     (1)          (2)                                                 
      Squamous Cell Carcinoma                                       1 (100%)     1 (50%)                                            
      Pharyngeal, Squamous Cell Papilloma                                        1 (50%)                                            
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Fibroma                                                       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)         (50)                      
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma                                                1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
   Tongue                                             (1)                       (1)          (1)                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Schwannoma Malignant                                                       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Pheochromocytoma Complex                         1 (2%)                                              1 (2%)                   
      Pheochromocytoma Benign                          5 (10%)      3 (6%)       2 (4%)       2 (4%)       8 (16%)                  
      Bilateral, Pheochromocytoma Benign               1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (49)                      
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Pars Distalis, Adenoma                           8 (16%)      9 (18%)      7 (14%)      9 (18%)      6 (12%)                  
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                    2 (4%)                   
      Pars Nervosa, Adenoma                                                                   1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  7 (14%)      4 (8%)       9 (18%)     10 (20%)     10 (20%)                  
      C-Cell, Carcinoma                                2 (4%)       2 (4%)                    2 (4%)       1 (2%)                   
      Follicular Cell, Adenoma                         3 (6%)                                 2 (4%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                              2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (1)          (1)          (1)                       
      Adenoma                                                                                              1 (100%)                 
   Epididymis                                         (50)         (50)         (50)         (50)         (50)                      
   Preputial Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Adenoma                                          4 (8%)       3 (6%)       5 (10%)      4 (8%)       3 (6%)                   
      Carcinoma                                        1 (2%)                                 1 (2%)       1 (2%)                   
   Prostate                                           (50)         (50)         (50)         (50)         (50)                      
   Seminal Vesicle                                    (50)         (50)         (50)         (50)         (50)                      
   Testes                                             (50)         (50)         (50)         (50)         (50)                      
      Hemangiosarcoma                                                            1 (2%)                                             
      Bilateral, Interstitial Cell, Adenoma           46 (92%)     42 (84%)     46 (92%)     41 (82%)     44 (88%)                  
      Interstitial Cell, Adenoma                       3 (6%)       5 (10%)      3 (6%)       4 (8%)       3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Lymph Node                                         (15)         (20)         (10)         (10)         (12)                      
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skin                                          1 (5%)                                                          
   Lymph Node, Mandibular                             (50)         (49)         (50)         (50)         (50)                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)         (49)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Thymus                                             (50)         (47)         (49)         (47)         (49)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)         (50)                      
      Adenocarcinoma                                                1 (2%)                                                          
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
      Fibroadenoma                                     3 (6%)       2 (4%)                    3 (6%)       2 (4%)                   
      Fibroadenoma, Multiple                                        3 (6%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Adenoma                                            1 (2%)       2 (4%)       1 (2%)                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  4 (8%)       3 (6%)       2 (4%)       5 (10%)      4 (8%)                   
      Keratoacanthoma, Multiple                        1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
      Trichoepithelioma                                1 (2%)                    1 (2%)                                             
      Dermis, Schwannoma Malignant                                                            1 (2%)                                
      Epidermis, Melanoma Malignant                    1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)       3 (6%)       2 (4%)       2 (4%)                   
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                    1 (2%)       1 (2%)       1 (2%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma,                                                                                    
           Metastatic, Skin                                         1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Myxoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Myxosarcoma                                           1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)       1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Schwannoma Malignant                     2 (4%)                                                          
      Subcutaneous Tissue, Pinna, Melanoma                                                                                          
          Malignant                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma                                                                            1 (2%)                                
      Rib, Carcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
   Skeletal Muscle                                                                                        (2)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)       1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Pheochromocytoma Complex, Metastatic,                                                                                         
          Adrenal Medulla                                                                                  1 (2%)                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
      Bronchiole, Carcinoma                            1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                                                 1 (2%)                                
   Trachea                                            (50)         (50)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (3)          (2)          (3)                       
      Melanoma Malignant                                                                      1 (50%)                               
   Zymbal's Gland                                                  (1)                                    (1)                       
      Carcinoma                                                     1 (100%)                               1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Lipoma                                                                                               1 (2%)                   
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (50)                      
      Lipoma                                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Leukemia Mononuclear                            33 (66%)     35 (70%)     39 (78%)     32 (64%)     29 (58%)                  
      Lymphoma Malignant                                                                                   1 (2%)                   
      Mesothelioma Malignant                           2 (4%)       2 (4%)       4 (8%)       4 (8%)       2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 15:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREAT      VEHICLE      1000 PPM     2000 PPM     4000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          50          49          50                           
     Total Primary Neoplasms                          143         134         143         138         129                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          47          50          48          48                           
     Total Benign Neoplasms                            97          86          91          92          87                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          41          41          37          33                           
     Total Malignant Neoplasms                         46          48          52          46          42                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4                       1           1                           
     Total Metastatic Neoplasm                          1          17                       1           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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