Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/13064

TDMS Study 61427-07 Pathology Tables

NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59

                                                          FINAL#2/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  1314-62-1

       Lock Date:  08/18/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           20           17           15                                     
    Natural Death                                      3            6            4            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           24           29           30                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (48)         (49)                                   
   Intestine Small, Duodenum                          (48)         (47)         (48)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (9)          (20)         (22)         (15)                                   
      Histiocytic Sarcoma                                                        1 (5%)                                             
   Oral Mucosa                                                     (1)          (1)                                                 
      Pharyngeal, Squamous Cell Carcinoma                                        1 (100%)                                           
      Pharyngeal, Squamous Cell Papilloma                           1 (100%)                                                        
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Tongue                                                          (2)          (4)          (2)                                    
      Squamous Cell Carcinoma                                       1 (50%)                                                         
      Squamous Cell Papilloma                                       1 (50%)      1 (25%)                                            
   Tooth                                              (3)          (2)          (2)          (1)                                    
      Odontoma                                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                    1 (2%)                    1 (2%)                                
      Pheochromocytoma Benign                          2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (49)         (50)                                   
      Pars Distalis, Adenoma                          31 (63%)     29 (58%)     24 (49%)     30 (60%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  2 (4%)       4 (8%)       3 (6%)       3 (6%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                                          
      Follicular Cell, Carcinoma                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (49)         (50)                                   
      Adenoma                                          2 (4%)                    3 (6%)                                             
      Carcinoma                                                     1 (2%)       2 (4%)       3 (6%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   1 (2%)                    1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Polyp Stromal                                    6 (12%)      3 (6%)       7 (14%)     13 (26%)                               
      Sarcoma Stromal                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (3)          (3)          (3)          (2)                                    
      Carcinoma, Metastatic, Mammary Gland             1 (33%)                                                                      
      Pancreatic, Histiocytic Sarcoma                  1 (33%)                                                                      
   Lymph Node, Bronchial                              (42)         (45)         (44)         (44)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mandibular                             (42)         (41)         (45)         (46)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mediastinal                            (48)         (50)         (50)         (48)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (49)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Carcinoma, Multiple                              1 (2%)                                                                       
      Fibroadenoma                                    12 (24%)      9 (18%)     18 (36%)     18 (36%)                               
      Fibroadenoma, Multiple                           4 (8%)       4 (8%)       2 (4%)       3 (6%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                  1 (2%)                                                          
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Schwannoma Malignant                                                       1 (2%)                                             
      Pinna, Neural Crest Tumor, Benign                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (2)                       (2)                                    
      Rhabdomyosarcoma                                                                        1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                         2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lung                                               (49)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  3 (6%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Carcinoma, Metastatic, Clitoral Gland                                                   1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Mediastinum, Histiocytic Sarcoma                                           1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Chondroma                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Papilloma                                                                               1 (2%)                                
      Sarcoma Stromal, Metastatic, Uterus                                                     1 (2%)                                
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Leukemia Mononuclear                            21 (42%)     23 (46%)     22 (44%)     15 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          47          46          45                                       
     Total Primary Neoplasms                           93          93          96          96                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          39          41          39                                       
     Total Benign Neoplasms                            64          59          64          71                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          29          27          22                                       
     Total Malignant Neoplasms                         29          34          32          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                       2                                       
     Total Metastatic Neoplasm                          3           1                       2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           17           18           13                                     
    Natural Death                                      5            4            6           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           29           26           27                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)                                   
   Intestine Large, Cecum                             (46)         (48)         (45)         (46)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (45)         (47)         (45)         (43)                                   
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (50)         (50)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Mesentery                                          (8)          (18)         (12)         (9)                                    
      Fibrous Histiocytoma, Metastatic, Skin           1 (13%)                                                                      
   Oral Mucosa                                                     (3)                       (4)                                    
      Squamous Cell Carcinoma                                                                 1 (25%)                               
      Squamous Cell Papilloma                                       1 (33%)                                                         
      Pharyngeal, Squamous Cell Papilloma                           1 (33%)                                                         
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (49)         (50)                                   
   Tongue                                                                       (1)          (2)                                    
      Squamous Cell Papilloma                                                                 1 (50%)                               
   Tooth                                              (7)          (1)          (2)          (5)                                    
      Odontoma                                                                                1 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Pericardium, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Ganglioneuroma                                                                          1 (2%)                                
      Pheochromocytoma Malignant                       1 (2%)       2 (4%)                                                          
      Pheochromocytoma Complex                                                   2 (4%)                                             
      Pheochromocytoma Benign                          4 (8%)      10 (20%)      6 (12%)      6 (12%)                               
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Carcinoma                                        1 (2%)       4 (8%)       3 (6%)                                             
   Parathyroid Gland                                  (49)         (49)         (48)         (48)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          35 (70%)     35 (70%)     39 (78%)     32 (64%)                               
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
      C-Cell, Adenoma                                  1 (2%)       4 (8%)       4 (8%)       2 (4%)                                
      C-Cell, Carcinoma                                                          1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                   (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
   Preputial Gland                                    (50)         (50)         (49)         (50)                                   
      Carcinoma                                                     2 (4%)       2 (4%)       2 (4%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           21 (42%)     21 (42%)     18 (36%)     23 (46%)                               
      Interstitial Cell, Adenoma                      15 (30%)     11 (22%)     16 (32%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Lymph Node                                         (2)          (3)          (2)          (5)                                    
   Lymph Node, Bronchial                              (39)         (44)         (47)         (44)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Skin           1 (3%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (3%)                                                                       
   Lymph Node, Mandibular                             (44)         (48)         (46)         (45)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
   Lymph Node, Mediastinal                            (45)         (47)         (46)         (44)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (50)         (50)         (48)         (50)                                   
   Thymus                                             (49)         (49)         (49)         (50)                                   
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (49)         (50)                                   
      Carcinoma, Multiple                                           1 (2%)                                                          
      Fibroadenoma                                     2 (4%)       2 (4%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)       1 (2%)                                             
      Basal Cell Adenoma, Multiple                                  1 (2%)                                                          
      Basal Cell Carcinoma                                                       1 (2%)       1 (2%)                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrous Histiocytoma                             1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  3 (6%)       6 (12%)      2 (4%)       2 (4%)                                
      Keratoacanthoma, Multiple                        1 (2%)                                                                       
      Neural Crest Tumor, Benign                                                 1 (2%)                                             
      Schwannoma Benign                                                          1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
      Trichoepithelioma                                                                       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     2 (4%)                    4 (8%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      2 (4%)                    3 (6%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Cranium, Sarcoma, Metastatic, Skin               1 (2%)                                                                       
      Femur, Osteosarcoma                                           1 (2%)                                                          
      Mandible, Osteosarcoma                           1 (2%)                                                                       
   Skeletal Muscle                                                 (2)          (2)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (50%)                                            
      Carcinoma, Metastatic, Mammary Gland                          1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Glioma Malignant                                              1 (2%)                                                          
      Meningioma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
   Lung                                               (50)         (49)         (48)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       6 (12%)      5 (10%)      6 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                                2 (4%)       1 (2%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin           2 (4%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)                                
   Pleura                                                                       (2)          (1)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (50%)                                            
   Trachea                                            (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Lacrimal Gland                                     (1)                                                                           
      Fibrosarcoma, Metastatic, Skin                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)         (48)         (50)                                   
      Papilloma                                                     1 (2%)                    1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            22 (44%)     21 (42%)     19 (38%)     17 (34%)                               
      Lymphoma Malignant                                            1 (2%)                                                          
      Mesothelioma Malignant                           1 (2%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 61427-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:03:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          1.0          2.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          49          49                                       
     Total Primary Neoplasms                          124         147         138         120                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          47          49          46                                       
     Total Benign Neoplasms                            93         108         103          93                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          31          30          24                                       
     Total Malignant Neoplasms                         31          39          35          27                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           4           2           1                                       
     Total Metastatic Neoplasm                         19           6           7           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------