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TDMS Study 61427-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:29:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:29:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:29:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                VANADIUM PENTOXIDE                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Harderian Gland                        Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma                                                               
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Spleen                                 Hemangiosarcoma                                                                              
Thyroid Gland: Follicular Cell         Adenoma                                                                                      
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma                                                               
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                 VANADIUM PENTOXIDE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/49 (2%)    1/50 (2%)   |2/49 (4%)    0/50 (0%)    0/48 (0%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/43.43      1/45.18      1/40.58     |2/45.22      0/41.52      0/39.39      3/42.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         2.5%        |4.4%         0.0%         0.0%         7.1%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/35 (0%)    0/27 (0%)   |2/38 (5%)    0/32 (0%)    0/30 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          639          667         |731 (T)      ---          ---          728          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.204      (e)          P=0.500      P=0.450     |P=0.206      P=0.277N     P=0.292N     P=0.414      | 
|POLY 3             |     P=0.203      (e)          P=0.493      P=0.472     |P=0.244      P=0.257N     P=0.269N     P=0.472      | 
|POLY 1.5           |     P=0.217      (e)          P=0.494      P=0.483     |P=0.247      P=0.249N     P=0.258N     P=0.488      | 
|POLY 6             |     P=0.185      (e)          P=0.491      P=0.457     |P=0.242      P=0.266N     P=0.278N     P=0.454      | 
|LOGISTIC REGRESSION|     P=0.285      (e)          P=0.530      P=0.533     |P=0.216      (e)          (e)          P=0.435      | 
|COCH-ARM / FISHERS |     P=0.237      (e)          P=0.495      P=0.500     |P=0.243      P=0.242N     P=0.253N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   4/50 (8%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     8/46.90      5/44.10      4/46.66      1/40.58     |2/45.55      1/41.52      1/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     17.1%        11.3%        8.6%         2.5%        |4.4%         2.4%         2.5%         0.0%         | 
|TERMINAL (d)       |     7/39 (18%)   5/33 (15%)   1/36 (3%)    0/27 (0%)   |2/38 (5%)    1/32 (3%)    1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     698          729 (T)      617          667         |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035N*    P=0.390N     P=0.220N     P=0.061N    |P=0.184N     P=0.560N     P=0.583N     P=0.277N     | 
|POLY 3             |     P=0.018N*    P=0.316N     P=0.179N     P=0.028N*   |P=0.157N     P=0.532N     P=0.545N     P=0.248N     | 
|POLY 1.5           |     P=0.015N*    P=0.300N     P=0.179N     P=0.022N*   |P=0.154N     P=0.523N     P=0.529N     P=0.241N     | 
|POLY 6             |     P=0.021N*    P=0.338N     P=0.179N     P=0.037N*   |P=0.161N     P=0.544N     P=0.559N     P=0.255N     | 
|LOGISTIC REGRESSION|     P=0.019N*    P=0.357N     P=0.179N     P=0.040N*   |P=0.184N     P=0.560N     P=0.583N     (e)          | 
|COCH-ARM / FISHERS |     P=0.012N*    P=0.277N     P=0.178N     P=0.015N*   |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   5/50 (10%)   2/50 (4%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     8/46.90      5/44.10      5/46.66      2/40.58     |2/45.55      1/41.52      1/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     17.1%        11.3%        10.7%        4.9%        |4.4%         2.4%         2.5%         0.0%         | 
|TERMINAL (d)       |     7/39 (18%)   5/33 (15%)   2/36 (6%)    1/27 (4%)   |2/38 (5%)    1/32 (3%)    1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     698          729 (T)      617          667         |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.103N     P=0.390N     P=0.328N     P=0.140N    |P=0.184N     P=0.560N     P=0.583N     P=0.277N     | 
|POLY 3             |     P=0.058N     P=0.316N     P=0.279N     P=0.074N    |P=0.157N     P=0.532N     P=0.545N     P=0.248N     | 
|POLY 1.5           |     P=0.050N     P=0.300N     P=0.279N     P=0.061N    |P=0.154N     P=0.523N     P=0.529N     P=0.241N     | 
|POLY 6             |     P=0.069N     P=0.338N     P=0.279N     P=0.094N    |P=0.161N     P=0.544N     P=0.559N     P=0.255N     | 
|LOGISTIC REGRESSION|     P=0.064N     P=0.357N     P=0.279N     P=0.103N    |P=0.184N     P=0.560N     P=0.583N     (e)          | 
|COCH-ARM / FISHERS |     P=0.040N*    P=0.277N     P=0.277N     P=0.046N*   |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  17/50 (34%)  10/50 (20%)  7/50 (14%)  |6/50 (12%)   7/50 (14%)   9/50 (18%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     15/46.92     17/45.91     10/46.26     7/41.42     |6/46.22      7/42.06      9/42.16      2/43.59      | 
|POLY-3 PERCENT (g) |     32.0%        37.0%        21.6%        16.9%       |13.0%        16.6%        21.4%        4.6%         | 
|TERMINAL (d)       |     14/39 (36%)  14/33 (42%)  8/36 (22%)   4/27 (15%)  |5/38 (13%)   6/32 (19%)   4/30 (13%)   1/32 (3%)    | 
|FIRST INCIDENCE    |     692          514          639          541         |505          564          416          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.084N     P=0.228      P=0.239N     P=0.216N    |P=0.179N     P=0.384      P=0.175      P=0.186N     | 
|POLY 3             |     P=0.028N*    P=0.384      P=0.185N     P=0.080N    |P=0.137N     P=0.427      P=0.223      P=0.152N     | 
|POLY 1.5           |     P=0.021N*    P=0.397      P=0.182N     P=0.063N    |P=0.123N     P=0.448      P=0.245      P=0.141N     | 
|POLY 6             |     P=0.040N*    P=0.366      P=0.189N     P=0.108N    |P=0.154N     P=0.403      P=0.212      P=0.165N     | 
|LOGISTIC REGRESSION|     P=0.027N*    P=0.362      P=0.205N     P=0.111N    |P=0.120N     P=0.462      P=0.294      P=0.136N     | 
|COCH-ARM / FISHERS |     P=0.014N*    P=0.415      P=0.178N     P=0.045N*   |P=0.120N     P=0.500      P=0.288      P=0.134N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  18/50 (36%)  14/50 (28%)  12/50 (24%) |6/50 (12%)   4/50 (8%)    4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     14/49.21     18/45.68     14/46.81     12/43.14    |6/45.73      4/41.80      4/40.29      6/43.66      | 
|POLY-3 PERCENT (g) |     28.5%        39.4%        29.9%        27.8%       |13.1%        9.6%         9.9%         13.7%        | 
|TERMINAL (d)       |     5/39 (13%)   13/33 (39%)  9/36 (25%)   5/27 (19%)  |5/38 (13%)   2/32 (6%)    3/30 (10%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     523          590          611          541         |686          660          639          695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.493      P=0.162      P=0.511      P=0.435     |P=0.414      P=0.480N     P=0.515N     P=0.514      | 
|POLY 3             |     P=0.391N     P=0.181      P=0.527      P=0.565N    |P=0.482      P=0.427N     P=0.451N     P=0.588      | 
|POLY 1.5           |     P=0.329N     P=0.211      P=0.552      P=0.502N    |P=0.499      P=0.410N     P=0.421N     P=0.608      | 
|POLY 6             |     P=0.477N     P=0.149      P=0.491      P=0.539     |P=0.464      P=0.448N     P=0.474N     P=0.565      | 
|LOGISTIC REGRESSION|     P=0.217N     P=0.299      P=0.560N     P=0.250N    |P=0.464      P=0.440N     P=0.462N     P=0.559      | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.260      P=0.588N     P=0.410N    |P=0.500      P=0.370N     P=0.370N     P=0.620N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  30/50 (60%)  22/50 (44%)  17/50 (34%) |12/50 (24%)  10/50 (20%)  13/50 (26%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     26/49.21     30/47.49     22/47.22     17/43.41    |12/46.40     10/42.34     13/42.49     8/43.76      | 
|POLY-3 PERCENT (g) |     52.8%        63.2%        46.6%        39.2%       |25.9%        23.6%        30.6%        18.3%        | 
|TERMINAL (d)       |     17/39 (44%)  22/33 (67%)  15/36 (42%)  9/27 (33%)  |10/38 (26%)  7/32 (22%)   7/30 (23%)   4/32 (13%)   | 
|FIRST INCIDENCE    |     523          514          611          541         |505          564          416          695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225N     P=0.119      P=0.406N     P=0.417N    |P=0.355N     P=0.571N     P=0.285      P=0.354N     | 
|POLY 3             |     P=0.045N*    P=0.204      P=0.341N     P=0.131N    |P=0.265N     P=0.501N     P=0.398      P=0.270N     | 
|POLY 1.5           |     P=0.027N*    P=0.231      P=0.313N     P=0.092N    |P=0.238N     P=0.473N     P=0.433      P=0.244N     | 
|POLY 6             |     P=0.080N     P=0.172      P=0.380N     P=0.198N    |P=0.293N     P=0.533N     P=0.381      P=0.300N     | 
|LOGISTIC REGRESSION|     P=0.017N*    P=0.296      P=0.273N     P=0.056N    |P=0.240N     P=0.472N     P=0.461      P=0.255N     | 
|COCH-ARM / FISHERS |     P=0.013N*    P=0.273      P=0.274N     P=0.053N    |P=0.234N     P=0.405N     P=0.500      P=0.227N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  30/50 (60%)  22/50 (44%)  17/50 (34%) |12/50 (24%)  10/50 (20%)  13/50 (26%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     26/49.21     30/47.49     22/47.22     17/43.41    |12/46.40     10/42.34     13/42.49     8/43.76      | 
|POLY-3 PERCENT (g) |     52.8%        63.2%        46.6%        39.2%       |25.9%        23.6%        30.6%        18.3%        | 
|TERMINAL (d)       |     17/39 (44%)  22/33 (67%)  15/36 (42%)  9/27 (33%)  |10/38 (26%)  7/32 (22%)   7/30 (23%)   4/32 (13%)   | 
|FIRST INCIDENCE    |     523          514          611          541         |505          564          416          695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225N     P=0.119      P=0.406N     P=0.417N    |P=0.355N     P=0.571N     P=0.285      P=0.354N     | 
|POLY 3             |     P=0.045N*    P=0.204      P=0.341N     P=0.131N    |P=0.265N     P=0.501N     P=0.398      P=0.270N     | 
|POLY 1.5           |     P=0.027N*    P=0.231      P=0.313N     P=0.092N    |P=0.238N     P=0.473N     P=0.433      P=0.244N     | 
|POLY 6             |     P=0.080N     P=0.172      P=0.380N     P=0.198N    |P=0.293N     P=0.533N     P=0.381      P=0.300N     | 
|LOGISTIC REGRESSION|     P=0.017N*    P=0.296      P=0.273N     P=0.056N    |P=0.240N     P=0.472N     P=0.461      P=0.255N     | 
|COCH-ARM / FISHERS |     P=0.013N*    P=0.273      P=0.274N     P=0.053N    |P=0.234N     P=0.405N     P=0.500      P=0.227N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  16/50 (32%)  26/50 (52%)  15/50 (30%) |1/50 (2%)    17/50 (34%)  23/50 (46%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     13/48.11     16/45.97     26/46.55     15/42.34    |1/45.55      17/43.94     23/44.66     19/45.06     | 
|POLY-3 PERCENT (g) |     27.0%        34.8%        55.9%        35.4%       |2.2%         38.7%        51.5%        42.2%        | 
|TERMINAL (d)       |     6/39 (15%)   11/33 (33%)  24/36 (67%)  10/27 (37%) |1/38 (3%)    9/32 (28%)   13/30 (43%)  14/32 (44%)  | 
|FIRST INCIDENCE    |     620          405          611          562         |731 (T)      530          281          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.064      P=0.212      P=0.005 **   P=0.127     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.143      P=0.276      P=0.003 **   P=0.263     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.207      P=0.301      P=0.004 **   P=0.322     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.082      P=0.240      P=0.002 **   P=0.196     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.221      P=0.363      P=0.005 **   P=0.350     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.326      P=0.330      P=0.007 **   P=0.412     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  29/50 (58%)  30/50 (60%)  35/50 (70%) |0/50 (0%)    23/50 (46%)  18/50 (36%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     12/47.01     29/48.14     30/48.13     35/48.09    |0/45.55      23/44.00     18/40.29     22/45.95     | 
|POLY-3 PERCENT (g) |     25.5%        60.3%        62.3%        72.8%       |0.0%         52.3%        44.7%        47.9%        | 
|TERMINAL (d)       |     11/39 (28%)  17/33 (52%)  21/36 (58%)  15/27 (56%) |0/38 (0%)    15/32 (47%)  15/30 (50%)  12/32 (38%)  | 
|FIRST INCIDENCE    |     667          530          534          394         |---          522          695          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  42/50 (84%)  43/50 (86%)  43/50 (86%) |1/50 (2%)    32/50 (64%)  35/50 (70%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     22/48.11     42/49.67     43/48.82     43/48.57    |1/45.55      32/45.55     35/44.85     32/46.96     | 
|POLY-3 PERCENT (g) |     45.7%        84.6%        88.1%        88.5%       |2.2%         70.3%        78.0%        68.1%        | 
|TERMINAL (d)       |     15/39 (39%)  26/33 (79%)  32/36 (89%)  22/27 (82%) |1/38 (3%)    20/32 (63%)  23/30 (77%)  20/32 (63%)  | 
|FIRST INCIDENCE    |     620          405          534          394         |731 (T)      522          281          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/48 (2%)    0/50 (0%)    1/49 (2%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/43.92      0/41.52      1/39.90      2/40.59      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         0.0%         2.5%         4.9%         | 
|TERMINAL (d)       |                                                        |1/37 (3%)    0/32 (0%)    1/30 (3%)    1/29 (3%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      ---          731 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.207      P=0.529N     P=0.715      P=0.435      | 
|POLY 3             |                                                        |P=0.236      P=0.511N     P=0.739      P=0.472      | 
|POLY 1.5           |                                                        |P=0.241      P=0.505N     P=0.750      P=0.484      | 
|POLY 6             |                                                        |P=0.230      P=0.519N     P=0.729      P=0.459      | 
|LOGISTIC REGRESSION|                                                        |P=0.218      (e)          P=0.715      P=0.455      | 
|COCH-ARM / FISHERS |                                                        |P=0.237      P=0.490N     P=0.747N     P=0.492      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |8/49 (16%)   6/50 (12%)   7/50 (14%)   3/47 (6%)    | 
|POLY-3 RATE (b)    |     1/46.78      0/42.11      0/44.85      0/39.35     |8/45.76      6/42.22      7/40.06      3/41.63      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |17.5%        14.2%        17.5%        7.2%         | 
|TERMINAL (d)       |     1/39 (3%)    0/32 (0%)    0/35 (0%)    0/26 (0%)   |6/38 (16%)   2/32 (6%)    6/30 (20%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |695          654          705          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347N     P=0.539N     P=0.522N     P=0.581N    |P=0.168N     P=0.514N     P=0.537      P=0.177N     | 
|POLY 3             |     P=0.286N     P=0.521N     P=0.508N     P=0.534N    |P=0.117N     P=0.450N     P=0.611N     P=0.130N     | 
|POLY 1.5           |     P=0.295N     P=0.516N     P=0.507N     P=0.522N    |P=0.108N     P=0.431N     P=0.568N     P=0.121N     | 
|POLY 6             |     P=0.272N     P=0.527N     P=0.511N     P=0.550N    |P=0.127N     P=0.469N     P=0.579      P=0.141N     | 
|LOGISTIC REGRESSION|     P=0.347N     (e)          (e)          (e)         |P=0.124N     P=0.449N     P=0.569      P=0.122N     | 
|COCH-ARM / FISHERS |     P=0.307N     P=0.510N     P=0.505N     P=0.505N    |P=0.106N     P=0.371N     P=0.483N     P=0.113N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |8/49 (16%)   6/50 (12%)   7/50 (14%)   3/47 (6%)    | 
|POLY-3 RATE (b)    |     2/46.78      0/42.11      0/44.85      0/39.35     |8/45.76      6/42.22      7/40.06      3/41.63      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |17.5%        14.2%        17.5%        7.2%         | 
|TERMINAL (d)       |     2/39 (5%)    0/32 (0%)    0/35 (0%)    0/26 (0%)   |6/38 (16%)   2/32 (6%)    6/30 (20%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |695          654          705          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.145N     P=0.283N     P=0.262N     P=0.331N    |P=0.168N     P=0.514N     P=0.537      P=0.177N     | 
|POLY 3             |     P=0.106N     P=0.261N     P=0.247N     P=0.278N    |P=0.117N     P=0.450N     P=0.611N     P=0.130N     | 
|POLY 1.5           |     P=0.110N     P=0.255N     P=0.245N     P=0.262N    |P=0.108N     P=0.431N     P=0.568N     P=0.121N     | 
|POLY 6             |     P=0.100N     P=0.269N     P=0.250N     P=0.298N    |P=0.127N     P=0.469N     P=0.579      P=0.141N     | 
|LOGISTIC REGRESSION|     P=0.145N     (e)          (e)          (e)         |P=0.124N     P=0.449N     P=0.569      P=0.122N     | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.258N     P=0.253N     P=0.253N    |P=0.106N     P=0.371N     P=0.483N     P=0.113N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      0/45.85      0/40.35     |2/46.00      0/41.52      2/41.28      2/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         4.9%         4.6%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |662          ---          416          728          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.416      P=0.291N     P=0.635      P=0.639      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.443      P=0.261N     P=0.654      P=0.674      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.451      P=0.253N     P=0.669      P=0.686      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.434      P=0.271N     P=0.642      P=0.659      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.434      P=0.235N     P=0.659N     P=0.692      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.444      P=0.247N     P=0.691N     P=0.691N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |2/50 (4%)    0/48 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      0/45.85      3/40.58     |2/45.92      0/41.52      1/39.90      2/43.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.4%        |4.4%         0.0%         2.5%         4.6%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    2/27 (7%)   |1/38 (3%)    0/32 (0%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          667         |626          ---          731 (T)      653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   (e)          (e)          P=0.072     |P=0.427      P=0.277N     P=0.576N     P=0.638      | 
|POLY 3             |     P=0.010 *    (e)          (e)          P=0.095     |P=0.468      P=0.260N     P=0.549N     P=0.677      | 
|POLY 1.5           |     P=0.010 *    (e)          (e)          P=0.105     |P=0.472      P=0.253N     P=0.532N     P=0.687      | 
|POLY 6             |     P=0.009 **   (e)          (e)          P=0.085     |P=0.464      P=0.269N     P=0.563N     P=0.665      | 
|LOGISTIC REGRESSION|     P=0.008 **   (e)          (e)          P=0.089     |P=0.471      P=0.245N     P=0.523N     P=0.695N     | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |P=0.474      P=0.258N     P=0.508N     P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.78      1/44.10      0/45.85      0/40.35     |2/45.69      0/41.52      1/40.21      0/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         2.3%         0.0%         0.0%        |4.4%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    1/33 (3%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |695          ---          662          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.558N     P=0.256N     P=0.322N    |P=0.212N     P=0.277N     P=0.568N     P=0.267N     | 
|POLY 3             |     P=0.102N     P=0.521N     P=0.242N     P=0.272N    |P=0.184N     P=0.259N     P=0.544N     P=0.248N     | 
|POLY 1.5           |     P=0.101N     P=0.512N     P=0.240N     P=0.257N    |P=0.183N     P=0.252N     P=0.528N     P=0.241N     | 
|POLY 6             |     P=0.102N     P=0.531N     P=0.244N     P=0.292N    |P=0.185N     P=0.268N     P=0.556N     P=0.257N     | 
|LOGISTIC REGRESSION|     P=0.132N     P=0.558N     (e)          (e)         |P=0.191N     P=0.255N     P=0.521N     P=0.245N     | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.188N     P=0.247N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.78      1/44.10      0/45.85      0/40.35     |2/45.69      0/41.52      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         2.3%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    1/33 (3%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |695          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.558N     P=0.256N     P=0.322N    |P=0.131N     P=0.277N     P=0.284N     P=0.267N     | 
|POLY 3             |     P=0.102N     P=0.521N     P=0.242N     P=0.272N    |P=0.109N     P=0.259N     P=0.268N     P=0.248N     | 
|POLY 1.5           |     P=0.101N     P=0.512N     P=0.240N     P=0.257N    |P=0.110N     P=0.252N     P=0.257N     P=0.241N     | 
|POLY 6             |     P=0.102N     P=0.531N     P=0.244N     P=0.292N    |P=0.108N     P=0.268N     P=0.278N     P=0.257N     | 
|LOGISTIC REGRESSION|     P=0.132N     P=0.558N     (e)          (e)         |P=0.122N     P=0.255N     P=0.263N     P=0.245N     | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/48 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.78      0/44.10      0/45.85      2/40.35     |0/45.55      1/41.80      0/39.85      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/33 (0%)    0/36 (0%)    2/27 (7%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          654          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    (e)          (e)          P=0.172     |P=0.584N     P=0.471      (e)          (e)          | 
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.215     |P=0.584N     P=0.483      (e)          (e)          | 
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.228     |P=0.578N     P=0.488      (e)          (e)          | 
|POLY 6             |     P=0.041 *    (e)          (e)          P=0.199     |P=0.591N     P=0.477      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.172     |P=0.570N     P=0.506      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.048 *    (e)          (e)          P=0.258     |P=0.568N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.74      2/41.52      3/39.96      1/43.48      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         4.8%         7.5%         2.3%         | 
|TERMINAL (d)       |                                                        |1/38 (3%)    2/32 (6%)    3/30 (10%)   1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |683          731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.463N     P=0.627      P=0.396      P=0.551N     | 
|POLY 3             |                                                        |P=0.420N     P=0.659      P=0.439      P=0.518N     | 
|POLY 1.5           |                                                        |P=0.407N     P=0.669      P=0.461      P=0.507N     | 
|POLY 6             |                                                        |P=0.435N     P=0.645      P=0.420      P=0.530N     | 
|LOGISTIC REGRESSION|                                                        |P=0.436N     P=0.656      P=0.424      P=0.516N     | 
|COCH-ARM / FISHERS |                                                        |P=0.404N     P=0.691N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    2/50 (4%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.74      2/41.52      4/40.77      1/43.48      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         4.8%         9.8%         2.3%         | 
|TERMINAL (d)       |                                                        |1/38 (3%)    2/32 (6%)    3/30 (10%)   1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |683          731 (T)      416          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.487N     P=0.627      P=0.252      P=0.551N     | 
|POLY 3             |                                                        |P=0.448N     P=0.659      P=0.286      P=0.518N     | 
|POLY 1.5           |                                                        |P=0.433N     P=0.669      P=0.305      P=0.507N     | 
|POLY 6             |                                                        |P=0.465N     P=0.645      P=0.270      P=0.530N     | 
|LOGISTIC REGRESSION|                                                        |P=0.433N     P=0.656      P=0.337      P=0.516N     | 
|COCH-ARM / FISHERS |                                                        |P=0.431N     P=0.691N     P=0.339      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/44.10      1/45.90      0/40.35     |0/45.55      0/41.52      2/40.21      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.2%         0.0%        |0.0%         0.0%         5.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/33 (3%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      718          ---         |---          ---          662          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.666N     P=0.467      P=0.490      (e)         |P=0.567      (e)          P=0.194      (e)          | 
|POLY 3             |     P=0.632N     P=0.488      P=0.496      (e)         |P=0.591      (e)          P=0.210      (e)          | 
|POLY 1.5           |     P=0.617N     P=0.493      P=0.498      (e)         |P=0.600      (e)          P=0.220      (e)          | 
|POLY 6             |     P=0.651N     P=0.483      P=0.494      (e)         |P=0.579      (e)          P=0.204      (e)          | 
|LOGISTIC REGRESSION|     P=0.655N     P=0.467      P=0.495      (e)         |P=0.593      (e)          P=0.221      (e)          | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/46.78      1/44.10      1/45.85      3/40.58     |2/45.92      0/41.52      1/39.96      3/44.19      | 
|POLY-3 PERCENT (g) |     2.1%         2.3%         2.2%         7.4%        |4.4%         0.0%         2.5%         6.8%         | 
|TERMINAL (d)       |     1/39 (3%)    1/33 (3%)    1/36 (3%)    2/27 (7%)   |1/38 (3%)    0/32 (0%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      667         |626          ---          731 (T)      611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.097      P=0.724      P=0.744      P=0.196     |P=0.215      P=0.277N     P=0.576N     P=0.439      | 
|POLY 3             |     P=0.140      P=0.747      P=0.756      P=0.256     |P=0.245      P=0.260N     P=0.548N     P=0.482      | 
|POLY 1.5           |     P=0.150      P=0.753      P=0.758      P=0.276     |P=0.248      P=0.253N     P=0.530N     P=0.494      | 
|POLY 6             |     P=0.129      P=0.741      P=0.754      P=0.233     |P=0.243      P=0.270N     P=0.563N     P=0.470      | 
|LOGISTIC REGRESSION|     P=0.110      P=0.724      P=0.744      P=0.230     |P=0.243      P=0.238N     P=0.521N     P=0.499      | 
|COCH-ARM / FISHERS |     P=0.163      P=0.753N     P=0.753N     P=0.309     |P=0.242      P=0.247N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |2/50 (4%)    0/50 (0%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/46.78      2/44.10      2/45.90      3/40.58     |2/45.92      0/41.52      3/40.21      3/44.19      | 
|POLY-3 PERCENT (g) |     2.1%         4.5%         4.4%         7.4%        |4.4%         0.0%         7.5%         6.8%         | 
|TERMINAL (d)       |     1/39 (3%)    2/33 (6%)    1/36 (3%)    2/27 (7%)   |1/38 (3%)    0/32 (0%)    2/30 (7%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          667         |626          ---          662          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.137      P=0.442      P=0.476      P=0.196     |P=0.201      P=0.277N     P=0.403      P=0.439      | 
|POLY 3             |     P=0.188      P=0.479      P=0.493      P=0.256     |P=0.235      P=0.260N     P=0.440      P=0.482      | 
|POLY 1.5           |     P=0.206      P=0.488      P=0.496      P=0.276     |P=0.240      P=0.253N     P=0.462      P=0.494      | 
|POLY 6             |     P=0.168      P=0.469      P=0.489      P=0.233     |P=0.231      P=0.270N     P=0.423      P=0.470      | 
|LOGISTIC REGRESSION|     P=0.155      P=0.442      P=0.482      P=0.230     |P=0.233      P=0.238N     P=0.472      P=0.499      | 
|COCH-ARM / FISHERS |     P=0.232      P=0.500      P=0.500      P=0.309     |P=0.232      P=0.247N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/44.43      0/45.85      0/40.35     |3/45.76      1/42.13      1/39.98      1/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |6.6%         2.4%         2.5%         2.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          639          ---          ---         |695          530          725          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.590N     P=0.486      (e)          (e)         |P=0.272N     P=0.354N     P=0.384N     P=0.356N     | 
|POLY 3             |     P=0.577N     P=0.490      (e)          (e)         |P=0.247N     P=0.335N     P=0.355N     P=0.324N     | 
|POLY 1.5           |     P=0.574N     P=0.494      (e)          (e)         |P=0.242N     P=0.327N     P=0.336N     P=0.312N     | 
|POLY 6             |     P=0.580N     P=0.485      (e)          (e)         |P=0.253N     P=0.347N     P=0.371N     P=0.337N     | 
|LOGISTIC REGRESSION|     P=0.511N     P=0.559      (e)          (e)         |P=0.243N     P=0.301N     P=0.355N     P=0.325N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.242N     P=0.309N     P=0.309N     P=0.309N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |7/50 (14%)   4/50 (8%)    12/50 (24%)  5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/46.78      2/44.10      1/45.90      1/40.83     |7/45.55      4/42.19      12/42.05     5/44.20      | 
|POLY-3 PERCENT (g) |     4.3%         4.5%         2.2%         2.5%        |15.4%        9.5%         28.5%        11.3%        | 
|TERMINAL (d)       |     2/39 (5%)    2/33 (6%)    0/36 (0%)    0/27 (0%)   |7/38 (18%)   2/32 (6%)    7/30 (23%)   2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          586         |731 (T)      603          270          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.437N     P=0.634      P=0.524N     P=0.602N    |P=0.504      P=0.367N     P=0.068      P=0.493N     | 
|POLY 3             |     P=0.367N     P=0.673      P=0.507N     P=0.547N    |P=0.505N     P=0.306N     P=0.107      P=0.400N     | 
|POLY 1.5           |     P=0.356N     P=0.681      P=0.504N     P=0.528N    |P=0.488N     P=0.295N     P=0.123      P=0.385N     | 
|POLY 6             |     P=0.382N     P=0.662      P=0.511N     P=0.572N    |P=0.520N     P=0.319N     P=0.099      P=0.415N     | 
|LOGISTIC REGRESSION|     P=0.360N     P=0.634      P=0.518N     P=0.480N    |P=0.501N     P=0.311N     P=0.128      P=0.408N     | 
|COCH-ARM / FISHERS |     P=0.337N     P=0.691N     P=0.500N     P=0.500N    |P=0.500N     P=0.262N     P=0.154      P=0.380N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  31/50 (62%)  36/50 (72%)  21/50 (42%) |19/50 (38%)  23/50 (46%)  35/50 (70%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     31/48.94     31/47.26     36/47.85     21/43.65    |19/46.63     23/44.48     35/45.58     27/45.84     | 
|POLY-3 PERCENT (g) |     63.4%        65.6%        75.2%        48.1%       |40.7%        51.7%        76.8%        58.9%        | 
|TERMINAL (d)       |     22/39 (56%)  23/33 (70%)  28/36 (78%)  12/27 (44%) |15/38 (40%)  14/32 (44%)  23/30 (77%)  19/32 (59%)  | 
|FIRST INCIDENCE    |     499          405          611          541         |505          530          281          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.273      P=0.136      P=0.464N    |P=0.021 *    P=0.125      P<0.001 **   P=0.029 *    | 
|POLY 3             |     P=0.090N     P=0.493      P=0.144      P=0.098N    |P=0.027 *    P=0.199      P<0.001 **   P=0.058      | 
|POLY 1.5           |     P=0.054N     P=0.535      P=0.163      P=0.065N    |P=0.037 *    P=0.210      P<0.001 **   P=0.072      | 
|POLY 6             |     P=0.154N     P=0.425      P=0.125      P=0.155N    |P=0.018 *    P=0.193      P<0.001 **   P=0.046 *    | 
|LOGISTIC REGRESSION|     P=0.055N     P=0.571      P=0.178      P=0.067N    |P=0.041 *    P=0.201      P<0.001 **   P=0.066      | 
|COCH-ARM / FISHERS |     P=0.024N*    P=0.582N     P=0.198      P=0.036N*   |P=0.042 *    P=0.272      P<0.001 **   P=0.080      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 VANADIUM PENTOXIDE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  40/50 (80%)  38/50 (76%)  41/50 (82%) |17/50 (34%)  29/50 (58%)  32/50 (64%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     27/49.21     40/49.35     38/49.19     41/49.15    |17/46.75     29/45.63     32/43.73     33/48.50     | 
|POLY-3 PERCENT (g) |     54.9%        81.1%        77.3%        83.4%       |36.4%        63.6%        73.2%        68.0%        | 
|TERMINAL (d)       |     18/39 (46%)  25/33 (76%)  25/36 (69%)  19/27 (70%) |11/38 (29%)  17/32 (53%)  21/30 (70%)  17/32 (53%)  | 
|FIRST INCIDENCE    |     523          405          534          394         |626          522          270          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.005 **   P=0.029 *    P<0.001 **  |P=0.003 **   P=0.006 **   P<0.001 **   P=0.002 **   | 
|POLY 3             |     P=0.004 **   P=0.004 **   P=0.015 *    P<0.001 **  |P=0.002 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.004 **   P=0.004 **   P=0.015 *    P<0.001 **  |P=0.002 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.004 **   P=0.004 **   P=0.015 *    P=0.002 **  |P=0.002 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.013 *    P=0.009 **   P=0.020 *    P=0.010 *   |P=0.002 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.006 **   P=0.005 **   P=0.018 *    P=0.002 **  |P=0.002 **   P=0.013 *    P=0.002 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     42/50 (84%)  49/50 (98%)  47/50 (94%)  47/50 (94%) |32/50 (64%)  37/50 (74%)  44/50 (88%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     42/50.00     49/50.00     47/49.19     47/49.15    |32/47.69     37/46.23     44/47.37     40/48.50     | 
|POLY-3 PERCENT (g) |     84.0%        98.0%        95.5%        95.6%       |67.1%        80.0%        92.9%        82.5%        | 
|TERMINAL (d)       |     31/39 (80%)  32/33 (97%)  34/36 (94%)  25/27 (93%) |23/38 (61%)  23/32 (72%)  28/30 (93%)  24/32 (75%)  | 
|FIRST INCIDENCE    |     499          405          534          394         |505          522          270          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.019 *    P=0.110      P=0.003 **  |P=0.026 *    P=0.063      P<0.001 **   P=0.030 *    | 
|POLY 3             |     P=0.052      P=0.016 *    P=0.056      P=0.055     |P=0.038 *    P=0.116      P<0.001 **   P=0.064      | 
|POLY 1.5           |     P=0.067      P=0.016 *    P=0.067      P=0.065     |P=0.044 *    P=0.118      P=0.002 **   P=0.068      | 
|POLY 6             |     P=0.045 *    P=0.016 *    P=0.051      P=0.050     |P=0.035 *    P=0.117      P<0.001 **   P=0.061      | 
|LOGISTIC REGRESSION|     P=0.107      (e)          P=0.097      P=0.115     |P=0.033 *    P=0.105      P=0.002 **   P=0.055      | 
|COCH-ARM / FISHERS |     P=0.128      P=0.015 *    P=0.100      P=0.100     |P=0.033 *    P=0.194      P=0.005 **   P=0.059      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).