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TDMS Study 88007-06 Pathology Tables

NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99
Route: DOSED WATER                                                                                                Time: 09:40:38

                                                      2 YEAR CHRONIC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7632-00-0

       Lock Date:  03/20/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            7            2            4                                     
    Natural Death                                      9            9           11            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           34           37           41                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (50)         (50)         (49)                                   
   Intestine Large, Rectum                            (49)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
   Intestine Small, Ileum                             (49)         (49)         (50)         (50)                                   
      Leiomyosarcoma, Metastatic, Uterus                                         1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                         2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
      Hepatocellular Adenoma                           9 (18%)      6 (12%)      2 (4%)       5 (10%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)       1 (2%)       1 (2%)                                
      Hepatocholangiocarcinoma                         1 (2%)       1 (2%)                                                          
   Mesentery                                          (14)         (19)         (17)         (13)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (5%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (5%)       1 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (7%)       1 (5%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (6%)                                             
      Sarcoma                                                                    1 (6%)                                             
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (49)         (49)         (48)         (50)                                   
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 2 (4%)                                
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)       3 (6%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (48)         (49)                                   
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    3 (6%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (48)         (47)         (43)         (48)                                   
      Pars Distalis, Adenoma                           1 (2%)       3 (6%)                    1 (2%)                                
   Thyroid Gland                                      (49)         (49)         (48)         (49)                                   
      Bilateral, Follicular Cell, Adenoma                           1 (2%)                                                          
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                       (1)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (50)         (48)                                   
   Ovary                                              (47)         (49)         (50)         (49)                                   
      Cystadenoma                                                   2 (4%)       1 (2%)       3 (6%)                                
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
      Hemangioma                                                    2 (4%)       1 (2%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Luteoma                                                                                 1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Teratoma Benign                                               1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                                 3 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (7)          (7)          (8)          (4)                                    
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (14%)      1 (14%)                                                         
      Mediastinal, Sarcoma, Metastatic, Skin           1 (14%)                                                                      
   Lymph Node, Mandibular                             (47)         (46)         (48)         (48)                                   
   Lymph Node, Mesenteric                             (50)         (49)         (47)         (49)                                   
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)       2 (4%)                                             
   Thymus                                             (46)         (47)         (44)         (46)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             5 (10%)      1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                               2 (4%)                                
      Subcutaneous Tissue, Pinna, Fibroma                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Femur, Osteosarcoma                                                        1 (2%)                                             
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
   Skeletal Muscle                                    (3)          (2)          (1)          (3)                                    
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (50%)                                                         
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (33%)                                                                      
      Osteosarcoma, Metastatic, Bone                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
   Spinal Cord                                                                               (2)                                    
      Meninges, Meningioma Malignant                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       4 (8%)       2 (4%)       5 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                3 (6%)       2 (4%)       1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                2 (4%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Skin                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (1)          (2)                                    
      Adenoma                                                       1 (100%)                  2 (100%)                              
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant                               7 (14%)     10 (20%)      8 (16%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            21          32          31          32                                       
     Total Primary Neoplasms                           25          49          36          41                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          22          14          20                                       
     Total Benign Neoplasms                            13          25          14          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              12          20          19          17                                       
     Total Malignant Neoplasms                         12          24          22          17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6           4           3                                       
     Total Metastatic Neoplasm                         11          15          13           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            2            3            1                                     
    Natural Death                                      8            3            5           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           45           42           39                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (50)         (48)         (49)                                   
      Carcinoma                                                     1 (2%)                                                          
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                1 (2%)                                             
      Polyp Adenomatous                                2 (4%)       4 (8%)       3 (6%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                        5 (10%)      1 (2%)       1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Adenomatous                                                                       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Cholangiocarcinoma                                                                      1 (2%)                                
      Hemangiosarcoma                                  2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Hemangiosarcoma, Metastatic, Spleen              2 (4%)                                                                       
      Hepatoblastoma                                   5 (10%)      1 (2%)       2 (4%)                                             
      Hepatocellular Carcinoma                         9 (18%)     10 (20%)      6 (12%)      6 (12%)                               
      Hepatocellular Carcinoma, Multiple                                                      3 (6%)                                
      Hepatocellular Adenoma                          10 (20%)     15 (30%)      8 (16%)     13 (26%)                               
      Hepatocellular Adenoma, Multiple                 9 (18%)      2 (4%)       5 (10%)      5 (10%)                               
      Sarcoma                                                                    1 (2%)                                             
   Mesentery                                          (7)          (6)          (7)          (5)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (20%)                               
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (20%)                               
      Hepatoblastoma, Metastatic, Liver                                          1 (14%)                                            
      Sarcoma, Metastatic, Liver                                                 1 (14%)                                            
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Liver                                                 1 (2%)                                             
   Tooth                                              (5)          (5)          (4)          (1)                                    
      Odontoma                                                      2 (40%)      1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       2 (4%)       2 (4%)                                             
      Carcinoma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Prostate                                           (50)         (50)         (49)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Interstitial Cell, Adenoma                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  2 (4%)                                                                       
   Lymph Node                                         (1)          (1)          (3)          (5)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (20%)                               
      Pancreatic, Cholangiocarcinoma, Metastatic,                                                                                   
           Liver                                                                              1 (20%)                               
      Renal, Cholangiocarcinoma, Metastatic, Liver                                            1 (20%)                               
   Lymph Node, Mandibular                             (47)         (50)         (47)         (48)                                   
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (49)         (48)         (49)                                   
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  3 (6%)                    2 (4%)                                             
      Hemangiosarcoma, Metastatic, Bone Marrow         1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Liver                                         1 (2%)       1 (2%)                                
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
   Thymus                                             (37)         (39)         (38)         (42)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Brain                                       1 (2%)                                                                       
      Subcutaneous Tissue, Pinna, Melanoma                                                                                          
          Malignant                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    10 (20%)      5 (10%)      8 (16%)     10 (20%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       1 (2%)       3 (6%)       7 (14%)                               
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                      1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                2 (4%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Sarcoma, Metastatic, Brain                       1 (2%)                                                                       
      Sarcoma, Metastatic, Liver                                                 1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                 2 (4%)                                
      Mediastinum, Fibrosarcoma, Metastatic,                                                                                        
          Uncertain Primary Site                                    1 (2%)                                                          
      Mediastinum, Hemangiosarcoma, Metastatic,                                                                                     
           Bone Marrow                                 1 (2%)                                                                       
      Mediastinum, Sarcoma, Metastatic, Brain          1 (2%)                                                                       
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (4)          (6)          (1)                                    
      Adenoma                                          4 (80%)      3 (75%)      4 (67%)      1 (100%)                              
      Carcinoma                                                                  2 (33%)                                            
      Sarcoma, Metastatic, Brain                       1 (20%)                                                                      
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               2 (4%)                                
      Renal Tubule, Adenoma                                         1 (2%)                                                          
                                                                                                                                    
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant                               1 (2%)       1 (2%)       4 (8%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  11                                                               
NTP Experiment-Test: 88007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:40:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          35          36          38                                       
     Total Primary Neoplasms                           72          55          55          52                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          28          26          29                                       
     Total Benign Neoplasms                            39          37          32          31                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          15          20          20                                       
     Total Malignant Neoplasms                         33          18          23          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             13           4           7           7                                       
     Total Metastatic Neoplasm                         18           7          11          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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