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TDMS Study 88031-05 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                 DIPROPYLENE GLYCOL                                           DATE: 12/07/00  
EXPERIMENT: 88031 TEST: 05                                                                                        TIME: 10:26:17    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C88031      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                DIPROPYLENE GLYCOL                                          DATE: 12/07/00    
EXPERIMENT: 88031 TEST: 05                                                                                        TIME: 10:41:50    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C88031      
CONT: N01-ES-55388                                                                                                CAS: 25265-71-8   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                        
                                            CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                         
==================================================================================================================================  
            0.0%                       0.25%                               1.0%                               4.0%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    16.2    99.8      16.3    100.4    1.01      406     15.9    100.2    0.98     1588      9.4    101.7    0.58     3680       
  2    16.4   132.7      16.5    132.6    1.01      311     16.8    132.5    1.02     1269     15.7    122.1    0.96     5155       
  6    19.8   251.7      19.1    248.1    0.96      192     20.4    247.1    1.03      824     21.2    230.5    1.07     3684       
 10    17.9   316.3      17.5    311.0    0.98      141     18.7    307.9    1.04      608     19.0    282.0    1.06     2696       
 14    17.5   360.1      17.4    350.2    0.99      124     17.4    344.4    0.99      506     17.5    309.1    1.00     2263       
 18    18.3   394.6      17.7    386.1    0.97      114     17.2    375.4    0.94      457     18.9    339.7    1.03     2227       
 22    19.1   420.1      18.6    412.2    0.97      113     18.6    400.2    0.97      466     21.2    362.9    1.11     2339       
 26    19.3   432.3      19.2    426.4    0.99      112     17.9    412.0    0.93      436     21.9    375.2    1.13     2338       
 30    18.6   449.9      18.6    442.6    1.00      105     18.7    426.2    1.01      439     21.8    388.0    1.17     2249       
 34    18.1   464.1      19.3    455.4    1.07      106     19.0    440.9    1.05      432     22.6    398.6    1.25     2267       
 38    17.0   471.4      17.1    468.1    1.01       91     16.4    451.3    0.96      363     20.9    406.4    1.23     2057       
 42    17.7   484.3      17.7    482.9    1.00       92     18.1    466.8    1.02      387     22.6    416.2    1.28     2177       
 46    16.5   489.1      17.2    488.5    1.04       88     17.4    470.8    1.05      370     21.9    418.0    1.33     2100       
 50    17.4   497.5      17.6    494.5    1.01       89     18.3    477.8    1.05      384     27.0    419.2    1.55     2576       
 54    17.9   503.6      17.7    502.2    0.99       88     18.2    485.2    1.02      376     28.7    426.5    1.60     2690       
 58    16.4   511.8      17.0    510.6    1.04       83     16.9    495.3    1.03      342     26.9    424.0    1.64     2537       
 62    17.6   518.3      17.8    517.4    1.01       86     18.0    501.4    1.02      359     30.1    424.6    1.71     2836       
 66    16.9   509.7      17.4    511.3    1.03       85     17.8    494.9    1.05      359     31.0    415.6    1.83     2980       
 70    17.2   513.5      16.8    514.7    0.98       82     17.1    499.9    0.99      342     29.3    408.0    1.70     2877       
 74    16.4   513.3      16.1    520.7    0.98       77     16.9    501.0    1.03      338     35.0    404.3    2.13     3465       
 78    16.5   510.9      16.1    514.1    0.98       79     16.1    493.4    0.98      327     36.3    395.4    2.20     3671       
 82    16.9   511.3      16.5    512.6    0.98       80     16.3    495.1    0.96      329     34.6    386.7    2.05     3583       
 86    16.7   514.4      16.9    512.9    1.01       83     17.2    489.9    1.03      352     37.7    370.9    2.26     4061       
 90    17.2   511.8      17.4    513.5    1.01       85     16.9    493.6    0.98      343     29.9    350.5    1.74     3409       
 94    16.0   509.2      16.7    516.6    1.04       81     16.8    495.9    1.05      339     43.0    367.1    2.69     4685       
 98    18.5   519.6      18.0    514.4    0.97       88     17.9    486.0    0.97      369     35.9    330.9    1.94     4340       
102    18.1   513.3      16.2    506.4    0.90       80     18.7    489.0    1.03      382                                          
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   17.6   200.1      17.3    198.0    0.99      263     18.0    196.9    1.02     1072     16.3    184.1    0.92     3804       
SD(D)   1.7               1.3             0.02      119      2.0             0.03      440      5.2             0.23     1014       
CV(E)   9.5               7.3             2.1      45.5     11.1             2.7      41.1     31.6            25.1      26.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   17.9   446.4      18.0    440.7    1.01      103     17.9    426.6    1.00      424     21.6    383.3    1.21     2259       
SD(D)   0.9               0.8             0.03       13      0.8             0.05       47      2.5             0.16      144       
CV(E)   5.1               4.5             2.9      12.4      4.6             4.7      11.0     11.6            13.2       6.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   17.1   512.4      17.0    512.9    0.99       83     17.3    493.9    1.01      350     33.2    392.0    1.96     3428       
SD(D)   0.8               0.6             0.04        3      0.8             0.03       17      4.7             0.32      680       
CV(E)   4.4               3.8             3.9       4.1      4.4             3.1       5.0     14.0            16.4      19.8       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                      
                                            CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                         
==================================================================================================================================  
            0.0%                       0.25%                               1.0%                               4.0%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    14.2    93.8      14.3     93.9     1.01     380     13.8     92.8     0.97    1490      8.3     92.5     0.58    3570       
  2    13.2   111.6      13.5    112.3     1.02     300     13.2    111.9     1.00    1182     12.2    105.0     0.92    4635       
  6    14.4   161.8      14.3    160.8     0.99     222     13.9    160.2     0.97     866     12.9    152.0     0.90    3392       
 10    13.2   184.0      14.0    180.5     1.06     194     12.9    180.3     0.98     718     11.6    165.2     0.88    2817       
 14    12.6   195.4      12.6    194.4     1.00     163     11.2    193.4     0.89     580     10.9    178.8     0.87    2431       
 18    12.9   208.9      12.6    206.0     0.98     153     11.7    204.0     0.91     575     11.1    187.2     0.86    2382       
 22    13.1   218.2      12.9    215.7     0.98     150     12.6    214.8     0.96     586     11.5    195.7     0.88    2343       
 26    13.1   222.1      12.7    219.4     0.97     145     11.9    219.3     0.91     542     11.2    198.5     0.85    2263       
 30    12.7   232.0      12.5    227.9     0.98     137     11.9    227.2     0.94     522     12.1    203.4     0.95    2383       
 34    13.1   240.7      13.6    235.2     1.04     145     13.3    236.2     1.02     564     13.3    208.4     1.02    2557       
 38    11.9   244.6      12.2    243.6     1.03     126     12.0    244.8     1.01     489     12.5    213.8     1.05    2339       
 42    12.2   253.6      12.3    252.0     1.01     122     12.0    254.5     0.98     472     12.5    218.4     1.02    2299       
 46    12.5   267.0      12.5    263.8     1.00     119     12.4    262.7     0.99     473     12.6    224.3     1.01    2238       
 50    13.6   279.4      13.7    274.9     1.01     125     12.9    274.9     0.95     469     13.1    230.5     0.96    2277       
 54    12.2   288.3      12.9    283.4     1.06     114     12.4    284.9     1.02     437     13.6    243.5     1.11    2231       
 58    12.0   298.5      12.4    292.8     1.03     106     12.0    294.6     1.00     406     13.2    251.0     1.10    2105       
 62    11.8   306.5      11.8    297.9     1.00      99     11.8    304.5     1.00     389     12.6    259.5     1.07    1938       
 66    12.4   312.7      12.7    303.0     1.02     105     12.6    310.0     1.02     405     13.1    262.7     1.06    1996       
 70    12.9   319.7      13.6    310.9     1.05     109     12.6    316.5     0.98     398     13.9    271.4     1.08    2043       
 74    11.8   327.6      12.8    319.7     1.08     100     12.2    324.3     1.03     375     13.3    277.6     1.13    1917       
 78    11.7   328.2      12.7    315.2     1.09     101     12.4    325.3     1.06     381     13.7    274.3     1.17    2002       
 82    12.5   337.4      12.5    321.1     1.00      98     13.1    328.3     1.05     398     13.1    285.0     1.05    1840       
 86    12.7   337.2      13.8    325.1     1.09     106     13.1    331.5     1.03     396     13.8    289.2     1.09    1916       
 90    13.2   342.0      12.9    328.3     0.98      99     13.4    335.6     1.02     400     14.5    288.2     1.10    2011       
 94    13.7   348.0      13.8    335.0     1.01     103     13.3    342.0     0.97     389     14.6    296.6     1.07    1963       
 98    13.8   350.8      14.5    338.7     1.05     107     14.1    347.8     1.02     406     15.1    295.2     1.09    2049       
102    14.4   350.5      14.8    346.6     1.03     107     13.7    352.1     0.95     390     14.3    301.3     0.99    1896       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   13.8   137.8      14.0    136.9     1.02     274     13.5    136.3     0.98    1064     11.2    128.7     0.82    3603       
SD(D)   0.6               0.4              0.03      83      0.5              0.02     343      2.1              0.16     759       
CV(E)   4.6               2.7              2.9     30.5      3.4              1.5     32.3     18.3             19.3     21.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   12.8   236.2      12.8    233.3     1.00     138     12.2    233.2     0.96     527     12.1    205.9     0.95    2351       
SD(D)   0.5               0.5              0.02      15      0.6              0.04      48      0.9              0.08      94       
CV(E)   4.0               4.0              2.2     10.8      5.1              4.7      9.2      7.1              8.1      4.0       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   12.7   326.7      13.2    316.7     1.04     104     12.8    322.9     1.01     398     13.8    276.6     1.08    1993       
SD(D)   0.9               0.9              0.04       5      0.7              0.03      15      0.7              0.04     102       
CV(E)   6.9               6.5              3.5      4.6      5.5              3.1      3.8      5.2              3.9      5.1       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                   
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                    0.25%                     1.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               99.8  50                100.4  50                100.2  50                101.7  50                               
  1  16.2  3367   99.8  50    16.3  3367  100.4  50    15.9  3305  100.2  50     9.4  3366  101.7  50                               
  2  16.4  4880  132.7  50    16.5  4884  132.6  50    16.8  4929  132.5  50    15.7  4859  122.1  50                               
  5  19.1  3493               18.9  3558               20.4  3522               22.5   845                                          
  6  19.8  4739  251.7  50    19.1  4802  248.1  50    20.4  4787  247.1  50    21.2  2792  230.5  50                               
  9  18.9  3365               18.6  3390               19.0  3206               18.9  3494                                          
 10  17.9  4882  316.3  50    17.5  4606  311.0  50    18.7  4799  307.9  50    19.0  4739  282.0  50                               
 13  17.6  3513               17.4  3451               17.3  3535               17.4  3497                                          
 14  17.5  4869  360.1  50    17.4  4913  350.2  50    17.4  4931  344.4  50    17.5  5001  309.1  50                               
 17  16.6  3622               16.9  3588               16.8  3539               18.0  3135                                          
 18  18.3  4434  394.6  50    17.7  4836  386.1  50    17.2  4904  375.4  50    18.9  4894  339.7  50                               
 21  18.5  3371               17.7  3612               17.9  3596               20.3  3608                                          
 22  19.1  4823  420.1  50    18.6  4834  412.2  50    18.6  4842  400.2  50    21.2  3891  362.9  50                               
 25  20.3  3400               19.8  3609               18.0  3591               21.7  2979                                          
 26  19.3  4855  432.3  50    19.2  4859  426.4  50    17.9  4882  412.0  50    21.9  4826  375.2  50                               
 29  17.9  3518               17.5  3524               18.0  3524               21.3  3391                                          
 30  18.6  4710  449.9  50    18.6  4690  442.6  50    18.7  4701  426.2  50    21.8  4105  388.0  50                               
 33  17.5  3633               18.6  3639               18.3  3641               22.6  2551                                          
 34  18.1  4762  464.1  50    19.3  4795  455.4  50    19.0  4809  440.9  50    22.6  2204  398.6  50                               
 37  17.4  3616               17.4  3617               17.2  3612               21.6  2752                                          
 38  17.0  4901  471.4  50    17.1  4891  468.1  50    16.4  4921  451.3  50    20.9  3763  406.4  50                               
 41  17.2  3538               16.9  3631               17.2  3662               22.0  2939                                          
 42  17.7  4381  484.3  49    17.7  4753  482.9  50    18.1  4733  466.8  50    22.6  3077  416.2  50                               
 45  15.5  3527               15.3  3836               15.7  3845               21.8  3599                                          
 46  16.5  4550  489.1  49    17.2  4655  488.5  50    17.4  4477  470.8  50    21.9  3043  418.0  50                               
 49  16.7  3566               16.7  3734               17.1  3694               23.3  1472                                          
 50  17.4  4528  497.5  48    17.6  4708  494.5  50    18.3  4667  477.8  49    27.0  3785  419.2  50                               
 53  17.1  3274               17.4  3432               18.2  3368               27.9  2261                                          
 54  17.9  4649  503.6  48    17.7  4871  502.2  50    18.2  4771  485.2  49    28.7  4846  426.5  50                               
 57  16.9  3369               16.9  3593               17.6  3524               27.9  3589                                          
 58  16.4  4557  511.8  47    17.0  4811  510.6  50    16.9  4697  495.3  49    26.9  4787  424.0  49                               
 61  16.6  3391               17.4  3735               17.5  3541               30.5  5728                                          
 62  17.6  4247  518.3  47    17.8  4027  517.4  49    18.0  4205  501.4  49    30.1  2019  424.6  48                               
 65  16.9  3193               17.2  3223               17.1  3360               31.8  3115                                          
 66  16.9  4547  509.7  47    17.4  4770  511.3  48    17.8  4550  494.9  49    31.0  4331  415.6  45                               
 69  18.5  3169               19.0  3247               18.8  3332               34.6  3043                                          
 70  17.2  4213  513.5  47    16.8  4652  514.7  48    17.1  4750  499.9  49    29.3  4323  408.0  42                               
 73  17.3  3238               17.0  3256               17.0  3446               37.2  2706                                          
 74  16.4  4514  513.3  46    16.1  4561  520.7  47    16.9  4731  501.0  49    35.0  2859  404.3  39                               
 77  16.4  3456               15.3  3262               16.7  3703               38.1  3634                                          
 78  16.5  4525  510.9  46    16.1  4478  514.1  46    16.1  4788  493.4  49    36.3  2617  395.4  36                               
 81  16.1  3335               16.8  3106               16.3  3367               34.0  2411                                          
 82  16.9  2865  511.3  42    16.5  4013  512.6  42    16.3  4390  495.1  46    34.6  2749  386.7  29                               
 85  17.2  2862               16.9  2974               17.4  3128               40.6  1740                                          
 86  16.7  3687  514.4  39    16.9  3862  512.9  41    17.2  4041  489.9  43    37.7  2266  370.9  23                               
 89  16.5  2612               17.7  2741               16.4  2938               33.8   980                                          
 90  17.2  3730  511.8  39    17.4  3796  513.5  40    16.9  3838  493.6  39    29.9  1232  350.5  12                               
 93  16.5  2608               17.1  2756               16.8  2610               43.6   288                                          
 94  16.0  3487  509.2  37    16.7  3675  516.6  38    16.8  3280  495.9  34    43.0   380  367.1   4                               
 97  17.6  2235               18.1  2605               18.8  2193               42.7   141                                          
=========================================================================================================                           
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                   
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                    0.25%                     1.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS                             
==========================================================================================================                          
 98  18.5  2909  519.6  30    18.0  3594  514.4  36    17.9  3217  486.0  33    35.9   196  330.9   2                               
101  18.6  1728               17.7  2365               20.0  2159                                                                   
102  18.1  2421  513.3  25    16.2  3013  506.4  34    18.7  3027  489.0  31                                                        
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          200.1                    198.0                    196.9                    184.1                                   
14 TO 52         446.4                    440.7                    426.6                    383.3                                   
 > 52            512.4                    512.9                    493.9                    392.0                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                 
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                    0.25%                     1.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               93.8  50                 93.9  50                 92.8  50                 92.5  50                               
  1  14.2  3380   93.8  50    14.3  3390   93.9  50    13.8  3390   92.8  50     8.3  3380   92.5  50                               
  2  13.2  4799  111.6  50    13.5  4824  112.3  50    13.2  4839  111.9  50    12.2  4827  105.0  50                               
  5  14.0  2910               14.0  3273               13.6  3156               12.4  3580                                          
  6  14.4  2867  161.8  50    14.3  4346  160.8  50    13.9  4858  160.2  50    12.9  4814  152.0  50                               
  9  14.2  3246               13.1  3240               13.0  3605               12.9  3610                                          
 10  13.2  4865  184.0  50    14.0  4359  180.5  50    12.9  4541  180.3  50    11.6  4380  165.2  50                               
 13  12.9  3520               12.7  3168               11.8  3541               10.6  3480                                          
 14  12.6  4864  195.4  50    12.6  4881  194.4  50    11.2  4868  193.4  50    10.9  4946  178.8  50                               
 17  12.9  3591               13.4  2852               11.5  3522               11.0  3540                                          
 18  12.9  4894  208.9  50    12.6  4931  206.0  50    11.7  4985  204.0  50    11.1  4980  187.2  50                               
 21  12.9  3591               12.5  3590               12.1  3590               11.3  3600                                          
 22  13.1  4804  218.2  50    12.9  4826  215.7  50    12.6  4844  214.8  50    11.5  4806  195.7  50                               
 25  13.1  3576               12.7  3571               11.7  3570               11.4  3571                                          
 26  13.1  4817  222.1  50    12.7  4826  219.4  50    11.9  4850  219.3  50    11.2  4831  198.5  50                               
 29  12.6  3518               11.5  3561               10.6  3600               11.7  3561                                          
 30  12.7  4778  232.0  50    12.5  4310  227.9  50    11.9  4793  227.2  50    12.1  4794  203.4  50                               
 33  13.0  3640               12.9  3276               12.8  3640               12.8  3640                                          
 34  13.1  4755  240.7  50    13.6  4770  235.2  50    13.3  4783  236.2  50    13.3  4769  208.4  50                               
 37  11.2  3138               13.0  3569               12.6  3574               13.7  3197                                          
 38  11.9  4706  244.6  49    12.2  4845  243.6  50    12.0  4858  244.8  50    12.5  4900  213.8  50                               
 41  12.9  3288               12.8  3363               12.8  3370               13.1  3348                                          
 42  12.2  4316  253.6  49    12.3  4911  252.0  50    12.0  4925  254.5  50    12.5  4905  218.4  50                               
 45  12.2  3689               11.8  3756               12.3  3675               12.6  3771                                          
 46  12.5  4251  267.0  49    12.5  4607  263.8  50    12.4  4668  262.7  49    12.6  4733  224.3  50                               
 49  12.2  3688               12.4  3749               11.8  3670               12.6  3740                                          
 50  13.6  4463  279.4  49    13.7  4575  274.9  50    12.9  4608  274.9  49    13.1  4796  230.5  50                               
 53  13.6  3406               13.7  3474               13.2  3410               14.1  3501                                          
 54  12.2  4694  288.3  49    12.9  4811  283.4  50    12.4  4721  284.9  49    13.6  4781  243.5  50                               
 57  11.8  3705               12.0  3774               11.7  3696               12.9  3780                                          
 58  12.0  4108  298.5  49    12.4  4702  292.8  50    12.0  4630  294.6  49    13.2  4699  251.0  50                               
 61  12.2  3537               12.3  3606               12.0  3602               13.2  3695                                          
 62  11.8  4664  306.5  48    11.8  4697  297.9  48    11.8  4786  304.5  49    12.6  4897  259.5  50                               
 65  12.8  3301               13.1  3209               12.8  3327               13.3  3064                                          
 66  12.4  4716  312.7  48    12.7  4680  303.0  47    12.6  4920  310.0  49    13.1  4966  262.7  50                               
 69  12.6  3221               14.3  3168               13.2  3292               14.8  3360                                          
 70  12.9  4677  319.7  48    13.6  4589  310.9  47    12.6  4803  316.5  49    13.9  4960  271.4  50                               
 73  13.3  3253               14.3  3170               13.6  3305               14.4  3370                                          
 74  11.8  4738  327.6  48    12.8  4634  319.7  47    12.2  4864  324.3  49    13.3  4895  277.6  50                               
 77  11.9  3433               13.0  3421               13.0  3254               13.9  3179                                          
 78  11.7  4493  328.2  46    12.7  4532  315.2  47    12.4  4232  325.3  49    13.7  4615  274.3  48                               
 81  13.7  3022               13.6  3132               14.0  3322               14.1  3209                                          
 82  12.5  4359  337.4  44    12.5  4598  321.1  46    13.1  4925  328.3  49    13.1  4591  285.0  46                               
 85  13.2  3153               13.8  3086               12.3  3522               13.5  3155                                          
 86  12.7  3774  337.2  44    13.8  4078  325.1  43    13.1  4687  331.5  49    13.8  4131  289.2  44                               
 89  13.7  3139               13.5  3126               13.0  3255               13.8  3055                                          
 90  13.2  4050  342.0  42    12.9  4073  328.3  41    13.4  4313  335.6  45    14.5  4043  288.2  42                               
 93  13.5  2851               14.3  2709               13.4  3067               14.6  2497                                          
 94  13.7  3817  348.0  40    13.8  3647  335.0  38    13.3  4151  342.0  43    14.6  3823  296.6  39                               
 97  13.9  2225               14.9  2672               13.8  2971               15.3  2670                                          
=========================================================================================================                           
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                 
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                    0.25%                     1.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS                             
==========================================================================================================                          
 98  13.8  2934  350.8  39    14.5  3233  338.7  36    14.1  3938  347.8  41    15.1  3594  295.2  37                               
101  14.6  2127               15.1  2471               14.3  2833               14.0  1834                                          
102  14.4  2873  350.5  33    14.8  3365  346.6  35    13.7  3854  352.1  40    14.3  2882  301.3  34                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          137.8                    136.9                    136.3                    128.7                                   
14 TO 52         236.2                    233.3                    233.2                    205.9                                   
 > 52            326.7                    316.7                    322.9                    276.6                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.