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TDMS Study 88031-05 Pathology Tables

NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02
Route: DOSED WATER                                                                                                Time: 10:26:57

                                                            FINAL#3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  25265-71-8

       Lock Date:  11/09/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9           10            6            6                                     
    Moribund Sacrifice                                11            9            6           12                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           37           31                                     
    Natural Death                                                                1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (48)         (46)                                   
   Intestine Large, Rectum                            (48)         (47)         (49)         (46)                                   
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Intestine Large, Cecum                             (46)         (43)         (47)         (45)                                   
   Intestine Small, Duodenum                          (47)         (46)         (47)         (47)                                   
   Intestine Small, Jejunum                           (45)         (44)         (47)         (44)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (44)         (41)         (47)         (45)                                   
   Liver                                              (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Sarcoma, Metastatic, Skin                                     1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Heart                       1 (2%)                                                          
   Mesentery                                          (15)         (13)         (13)         (11)                                   
      Histiocytic Sarcoma                                                        1 (8%)                                             
      Sarcoma                                                                    1 (8%)       2 (18%)                               
      Sarcoma, Metastatic, Ovary                       1 (7%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                          1 (8%)                                                          
   Pancreas                                           (47)         (48)         (48)         (48)                                   
      Adenoma                                          1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Sarcoma, Metastatic, Ovary                       1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Forestomach                               (50)         (49)         (50)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (47)         (49)         (47)                                   
   Tongue                                             (1)                       (1)          (1)                                    
      Squamous Cell Carcinoma                          1 (100%)                               1 (100%)                              
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Schwannoma Benign                                             2 (4%)       4 (8%)       1 (2%)                                
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (47)         (47)         (47)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (49)         (47)         (46)         (47)                                   
      Pheochromocytoma Malignant                       2 (4%)                                                                       
      Pheochromocytoma Benign                                       3 (6%)       1 (2%)                                             
   Islets, Pancreatic                                 (47)         (48)         (48)         (48)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (48)         (45)         (50)         (47)                                   
      Pars Distalis, Adenoma                          20 (42%)     18 (40%)     20 (40%)     13 (28%)                               
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (45)         (45)         (46)         (46)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  5 (11%)      8 (18%)      3 (7%)       3 (7%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
      Sarcoma, Metastatic, Mesentery                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (44)         (48)         (48)                                   
      Adenoma                                          6 (13%)      8 (18%)      4 (8%)       4 (8%)                                
      Carcinoma                                        4 (8%)       5 (11%)      2 (4%)       1 (2%)                                
      Sarcoma                                                                    1 (2%)                                             
      Bilateral, Adenoma                                            1 (2%)                                                          
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Ovary                                              (50)         (50)         (49)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Uterus                                             (50)         (48)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
      Polyp Stromal                                    8 (16%)     10 (21%)      6 (12%)     11 (22%)                               
      Polyp Stromal, Multiple                                       2 (4%)                    1 (2%)                                
      Sarcoma, Metastatic, Ovary                       1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                    2 (4%)                                             
   Vagina                                                          (1)                                                              
      Sarcoma, Metastatic, Skeletal Muscle                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (47)         (48)         (47)                                   
   Lymph Node                                         (15)         (11)         (8)          (14)                                   
      Mediastinal, Histiocytic Sarcoma                                           1 (13%)                                            
   Lymph Node, Mandibular                             (18)         (12)         (14)         (14)                                   
   Lymph Node, Mesenteric                             (49)         (47)         (49)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Ovary                       1 (2%)                                                                       
   Spleen                                             (48)         (48)         (49)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Ovary                       1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (48)         (49)         (48)         (39)                                   
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)         (49)                                   
      Carcinoma                                        4 (8%)       4 (8%)       2 (4%)       2 (4%)                                
      Fibroadenoma                                    20 (40%)     24 (49%)     14 (28%)     19 (39%)                               
      Fibroadenoma, Multiple                          16 (32%)     11 (22%)     16 (32%)      3 (6%)                                
      Sarcoma                                                       1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  2 (4%)       2 (4%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Skeletal                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Muscle                                                    1 (2%)                                                          
      Mediastinum, Schwannoma Malignant,                                                                                            
          Metastatic, Heart                                         1 (2%)                                                          
   Nose                                               (48)         (48)         (46)         (49)                                   
   Pleura                                                                                    (1)                                    
      Sarcoma, Metastatic, Mesentery                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (49)         (47)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mesenchymal Tumor Malignant                                                             1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Urinary Bladder                                    (50)         (48)         (48)         (46)                                   
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Leukemia Mononuclear                            10 (20%)     10 (20%)      4 (8%)      13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          46          46                                       
     Total Primary Neoplasms                          111         121          93          80                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          45          40          36                                       
     Total Benign Neoplasms                            83          93          70          56                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          24          20          21                                       
     Total Malignant Neoplasms                         28          28          23          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           4           2                                       
     Total Metastatic Neoplasm                          5          15           5           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           14           18           31                                     
    Natural Death                                     15            9            5           19                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           27           27                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (41)         (49)         (48)         (43)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Cecum                             (38)         (46)         (47)         (35)                                   
   Intestine Small, Duodenum                          (39)         (49)         (49)         (42)                                   
   Intestine Small, Jejunum                           (37)         (45)         (48)         (39)                                   
      Carcinoma                                                                  1 (2%)                                             
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (37)         (42)         (47)         (36)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (48)                                   
      Hepatocellular Adenoma                                                                  1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Mesentery                                          (14)         (11)         (6)          (4)                                    
   Oral Mucosa                                        (1)                                    (2)                                    
      Pharyngeal, Squamous Cell Papilloma                                                     1 (50%)                               
   Pancreas                                           (44)         (49)         (50)         (47)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Tissue NOS                          1 (2%)                                                          
      Mixed Tumor Benign                               2 (5%)                                                                       
   Salivary Glands                                    (49)         (49)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
      Sarcoma                                                       1 (2%)       3 (6%)                                             
      Schwannoma Malignant                                          2 (4%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (46)         (49)         (50)         (48)                                   
   Tongue                                                          (1)          (1)                                                 
      Squamous Cell Papilloma                                       1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                    1 (2%)                                             
      Schwannoma Benign                                2 (4%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (47)         (49)         (50)         (48)                                   
      Adenoma                                                       2 (4%)                                                          
      Carcinoma                                                                               1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Adrenal Medulla                                    (47)         (49)         (50)         (47)                                   
      Ganglioneuroma                                   1 (2%)                                                                       
      Pheochromocytoma Malignant                       5 (11%)                   2 (4%)                                             
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          4 (9%)       7 (14%)     11 (22%)      1 (2%)                                
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             
   Islets, Pancreatic                                 (44)         (48)         (50)         (47)                                   
      Adenoma                                          2 (5%)       3 (6%)                                                          
      Carcinoma                                                     4 (8%)                    2 (4%)                                
   Parathyroid Gland                                  (45)         (48)         (49)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)                                                          
   Pituitary Gland                                    (47)         (49)         (50)         (49)                                   
      Pars Distalis, Adenoma                          15 (32%)     21 (43%)     18 (36%)      7 (14%)                               
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (42)         (47)         (48)         (47)                                   
      C-Cell, Adenoma                                  4 (10%)      4 (9%)       6 (13%)                                            
      C-Cell, Carcinoma                                2 (5%)       3 (6%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)          (2)          (2)                                                 
   Tissue NOS                                                      (1)                       (1)                                    
      Fibrosarcoma                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
   Preputial Gland                                    (50)         (47)         (50)         (50)                                   
      Adenoma                                          3 (6%)       1 (2%)       3 (6%)       1 (2%)                                
      Carcinoma                                        3 (6%)       1 (2%)       1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Bilateral, Carcinoma                                                       1 (2%)                                             
   Prostate                                           (48)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       2 (4%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
   Seminal Vesicle                                    (43)         (48)         (49)         (46)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           39 (78%)     41 (82%)     41 (82%)     44 (88%)                               
      Interstitial Cell, Adenoma                       6 (12%)      4 (8%)       2 (4%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (46)         (48)         (50)         (48)                                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
   Lymph Node                                         (18)         (14)         (21)         (9)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (7%)                                                          
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                     1 (7%)                                                          
   Lymph Node, Mandibular                             (13)         (16)         (14)         (11)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (6%)                                                          
   Lymph Node, Mesenteric                             (44)         (48)         (49)         (47)                                   
   Spleen                                             (43)         (50)         (49)         (47)                                   
   Thymus                                             (39)         (48)         (43)         (41)                                   
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (41)         (47)         (44)                                   
      Fibroadenoma                                     1 (2%)       6 (15%)      1 (2%)                                             
      Fibroadenoma, Multiple                                        1 (2%)                                                          
   Skin                                               (48)         (48)         (49)         (49)                                   
      Keratoacanthoma                                  1 (2%)       2 (4%)       4 (8%)                                             
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Carcinoma                                       2 (4%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Sebaceous Gland, Adenoma                         1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     6 (13%)      5 (10%)      3 (6%)       1 (2%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     3 (6%)                    5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                               1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Granular Cell Tumor Benign                                    1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       
   Peripheral Nerve                                   (1)                                    (1)                                    
      Sarcoma                                          1 (100%)                                                                     
   Spinal Cord                                                                  (1)          (1)                                    
      Osteosarcoma, Metastatic, Bone                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       3 (6%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)       1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma, Metastatic, Salivary Glands                          1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                    1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)                                
   Nose                                               (46)         (50)         (50)         (49)                                   
   Trachea                                            (43)         (49)         (49)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (3)          (2)          (1)          (1)                                    
      Carcinoma                                        3 (100%)     2 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (50)         (50)         (48)                                   
      Lipoma                                                                     2 (4%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Stromal Nephroma                                 1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (46)         (50)         (49)         (49)                                   
      Sarcoma                                          1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            16 (32%)     20 (40%)     22 (44%)      5 (10%)                               
      Lymphoma Malignant                               1 (2%)                    1 (2%)                                             
      Mesothelioma Benign                              1 (2%)                                                                       
      Mesothelioma Malignant                           6 (12%)      2 (4%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02  
Route: DOSED WATER                                                                                                Time: 10:26:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          141         161         142          75                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          49          50          49                                       
     Total Benign Neoplasms                            95         117          97          62                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          34          35          12                                       
     Total Malignant Neoplasms                         46          44          45          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           4           2                                       
     Total Metastatic Neoplasm                          9           7           7           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
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