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TDMS Study 88031-06 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                 DIPROPYLENE GLYCOL                                           DATE: 06/18/01  
EXPERIMENT: 88031 TEST: 06                                                                                        TIME: 14:01:07    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C88031      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                DIPROPYLENE GLYCOL                                          DATE: 06/18/01    
EXPERIMENT: 88031 TEST: 06                                                                                        TIME: 14:16:38    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C88031      
CONT: N01-ES-55388                                                                                                CAS: 25265-71-8   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                            CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                         
==================================================================================================================================  
            0.0%                        1.0%                               2.0%                               4.0%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.4    23.7       3.4     24.1    1.00     1423      1.9     22.1    0.56     1743      1.1     18.2    0.32     2322       
  6     3.2    29.7       3.0     29.9    0.94      995      2.3     28.5    0.72     1638      2.0     25.6    0.63     3088       
 10     2.9    35.8       2.7     35.9    0.93      749      2.3     34.2    0.79     1344      1.9     30.5    0.66     2495       
 14     2.9    40.4       2.8     40.6    0.97      690      2.6     38.5    0.90     1342      2.2     34.3    0.76     2604       
 18     3.0    44.6       2.9     45.0    0.97      655      2.5     42.5    0.83     1175      2.3     37.9    0.77     2472       
 22     3.1    46.7       2.9     46.6    0.94      631      2.6     45.0    0.84     1162      2.5     41.0    0.81     2446       
 26     3.4    48.1       3.3     48.1    0.97      676      2.9     46.7    0.85     1230      2.5     42.0    0.74     2415       
 30     3.3    49.3       3.0     48.7    0.91      611      2.7     48.2    0.82     1110      2.4     43.5    0.73     2245       
 34     3.7    50.2       3.4     49.9    0.92      686      3.0     48.9    0.81     1227      2.5     43.5    0.68     2298       
 38     3.7    51.3       3.3     50.9    0.89      643      2.9     50.2    0.78     1139      2.4     44.3    0.65     2137       
 42     3.8    51.6       3.3     51.2    0.87      652      2.9     50.6    0.76     1127      2.3     43.9    0.61     2071       
 46     4.0    52.5       3.5     52.1    0.88      665      3.0     51.4    0.75     1160      2.5     44.0    0.63     2244       
 50     4.0    52.8       3.5     52.4    0.88      666      2.8     51.9    0.70     1089      2.3     44.6    0.58     2033       
 54     4.3    53.1       3.6     52.5    0.84      686      3.1     52.1    0.72     1188      2.6     45.7    0.60     2307       
 58     4.3    53.1       3.7     52.8    0.86      701      3.0     51.8    0.70     1155      2.6     45.6    0.60     2318       
 62     4.4    53.9       3.7     53.8    0.84      680      2.9     52.4    0.66     1122      2.7     47.3    0.61     2306       
 66     4.4    53.9       4.1     53.8    0.93      753      3.2     52.5    0.73     1208      3.0     48.1    0.68     2529       
 70     4.2    53.5       3.8     53.6    0.90      702      3.0     52.0    0.71     1150      3.0     47.8    0.71     2501       
 74     4.3    52.4       3.7     53.6    0.86      693      2.8     51.6    0.65     1099      3.0     46.6    0.70     2595       
 78     4.4    52.5       3.9     53.0    0.89      739      3.0     51.6    0.68     1149      2.9     47.2    0.66     2424       
 82     4.5    53.1       3.7     53.4    0.82      699      3.0     52.4    0.67     1142      3.0     46.2    0.67     2578       
 86     4.5    53.2       3.8     52.5    0.84      730      3.0     50.4    0.67     1180      2.4     43.4    0.53     2256       
 90     4.5    52.6       3.7     52.0    0.82      706      2.8     49.3    0.62     1156      2.0     41.4    0.44     1947       
 94     4.2    51.5       3.9     51.1    0.93      757      3.1     48.7    0.74     1254      2.6     40.0    0.62     2602       
 98     4.1    50.3       3.6     50.4    0.88      705      2.9     49.8    0.71     1161      2.5     39.6    0.61     2479       
102     4.3    48.6       3.6     49.1    0.84      729      3.1     48.4    0.72     1293      2.3     37.3    0.53     2464       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.2    29.7       3.0     30.0    0.96     1056      2.2     28.2    0.69     1575      1.6     24.8    0.53     2635       
SD(D)   0.3               0.4             0.04      341      0.2             0.12      207      0.5             0.18      402       
CV(E)   8.8              12.2             4.0      32.3     10.4            17.3      13.1     31.1            34.3      15.2       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.5    48.7       3.2     48.6    0.92      657      2.8     47.4    0.80     1176      2.4     41.9    0.69     2296       
SD(D)   0.4               0.3             0.04       25      0.2             0.06       74      0.1             0.08      186       
CV(E)  11.4               7.9             4.4       3.8      6.2             7.1       6.3      4.7            11.2       8.1       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.3    52.4       3.7     52.4    0.87      714      3.0     51.0    0.69     1174      2.7     44.3    0.61     2408       
SD(D)   0.1               0.1             0.04       25      0.1             0.04       53      0.3             0.08      182       
CV(E)   3.1               3.9             4.3       3.5      3.4             5.1       4.5     11.7            12.3       7.6       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                            CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                         
==================================================================================================================================  
            0.0%                        1.0%                               2.0%                               4.0%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.0    18.2       2.8     18.3     0.93    1549      2.0     18.3     0.67    2139      1.1     18.3     0.37    2316       
  2     2.8    19.2       2.7     19.1     0.96    1432      2.0     18.6     0.71    2140      1.3     17.0     0.46    2968       
  6     2.6    22.7       2.7     23.5     1.04    1152      2.3     22.2     0.88    2039      1.9     22.0     0.73    3479       
 10     2.6    27.4       2.5     27.8     0.96     904      2.2     26.4     0.85    1669      2.0     26.4     0.77    3058       
 14     3.0    32.7       2.5     33.3     0.83     756      2.4     32.3     0.80    1467      2.2     32.4     0.73    2766       
 18     2.5    38.0       2.5     38.4     1.00     651      2.3     36.8     0.92    1231      2.3     36.6     0.92    2468       
 22     2.5    43.0       2.9     43.2     1.16     683      2.8     41.1     1.12    1377      2.3     41.1     0.92    2191       
 26     2.5    45.7       2.4     46.3     0.96     518      2.2     43.7     0.88    1015      2.4     44.3     0.96    2143       
 30     2.5    48.1       2.5     47.7     1.00     520      2.4     46.1     0.96    1025      2.5     46.5     1.00    2118       
 34     2.5    51.5       2.4     51.1     0.96     476      2.3     49.2     0.92     935      2.6     49.9     1.04    2086       
 38     2.4    54.3       2.4     53.8     1.00     446      2.3     52.6     0.96     886      2.4     52.2     1.00    1811       
 42     2.4    56.3       2.4     55.9     1.00     430      2.7     54.7     1.13     972      2.5     54.5     1.04    1822       
 46     2.2    57.7       2.7     57.2     1.23     472      2.1     55.8     0.95     747      2.0     55.4     0.91    1479       
 50     2.3    59.6       2.2     58.5     0.96     369      2.1     58.2     0.91     710      2.1     57.2     0.91    1490       
 54     2.5    60.6       2.2     59.6     0.88     378      2.2     59.2     0.88     748      2.2     57.8     0.88    1531       
 58     2.7    60.5       2.5     60.4     0.93     410      2.3     58.8     0.85     774      2.3     57.0     0.85    1629       
 62     2.5    61.3       2.6     59.4     1.04     431      2.2     59.5     0.88     731      2.2     57.7     0.88    1496       
 66     2.5    61.4       2.4     60.0     0.96     397      2.3     59.0     0.92     776      2.3     57.7     0.92    1586       
 70     2.5    60.4       2.3     59.7     0.92     389      2.1     57.8     0.84     735      2.0     56.7     0.80    1445       
 74     4.2    60.7       2.8     59.2     0.67     472      2.5     58.5     0.60     867      3.1     56.4     0.74    2163       
 78     2.5    61.3       2.1     58.0     0.84     369      1.9     58.8     0.76     653      1.9     55.5     0.76    1370       
 82     2.5    61.1       2.3     60.2     0.92     390      2.6     59.6     1.04     859      2.7     56.6     1.08    1930       
 86     2.8    59.7       2.6     56.6     0.93     464      2.2     56.9     0.79     779      2.3     54.4     0.82    1684       
 90     2.9    57.7       2.4     53.9     0.83     449      2.5     55.9     0.86     884      2.0     50.5     0.69    1596       
 94     3.4    55.4       2.5     51.4     0.74     487      2.5     53.7     0.74     916      1.8     47.2     0.53    1506       
 98     3.5    53.4       2.4     51.0     0.69     467      2.4     54.4     0.69     882      1.7     45.7     0.49    1517       
102     3.7    52.4       2.6     51.0     0.70     518      2.5     53.2     0.68     957      2.0     45.2     0.54    1746       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    2.8    21.9       2.7     22.2     0.97    1259      2.1     21.4     0.78    1997      1.6     20.9     0.58    2955       
SD(D)   0.2               0.1              0.04     290      0.2              0.10     224      0.5              0.20     481       
CV(E)   6.9               5.1              4.6     23.0      7.1             13.4     11.2     30.4             33.9     16.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    2.5    48.7       2.5     48.5     1.01     532      2.3     47.1     0.96    1037      2.3     47.0     0.94    2037       
SD(D)   0.2               0.2              0.11     124      0.2              0.10     251      0.2              0.09     404       
CV(E)   8.4               8.4             10.9     23.3     10.1             10.5     24.2      7.3              9.5     19.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    2.9    58.9       2.5     57.0     0.85     432      2.3     57.3     0.81     812      2.2     53.7     0.77    1631       
SD(D)   0.6               0.2              0.12      47      0.2              0.12      88      0.4              0.17     214       
CV(E)  19.0               7.2             13.9     10.9      8.3             14.7     10.8     16.8             22.3     13.2       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                   
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                     1.0%                     2.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               22.5  50                 22.6  50                 22.5  50                 22.6  50                               
  1               22.5  50                 22.6  50                 22.5  50                 22.6  50                               
  2   3.4  8302   23.7  50     3.4  8295   24.1  50     1.9  8090   22.1  50     1.1  8256   18.2  50                               
  6   3.2  8346   29.7  50     3.0  8315   29.9  50     2.3  8273   28.5  50     2.0  8106   25.6  50                               
 10   2.9  8379   35.8  50     2.7  8408   35.9  50     2.3  8196   34.2  50     1.9  8374   30.5  50                               
 14   2.9  8247   40.4  50     2.8  8458   40.6  50     2.6  8201   38.5  50     2.2  8445   34.3  50                               
 18   3.0  8467   44.6  50     2.9  8301   45.0  50     2.5  8487   42.5  50     2.3  7956   37.9  50                               
 22   3.1  8218   46.7  50     2.9  7951   46.6  50     2.6  8119   45.0  50     2.5  7718   41.0  50                               
 26   3.4  8421   48.1  50     3.3  8367   48.1  50     2.9  7761   46.7  50     2.5  7240   42.0  50                               
 30   3.3  8411   49.3  50     3.0  8360   48.7  50     2.7  8425   48.2  50     2.4  8057   43.5  50                               
 34   3.7  8169   50.2  50     3.4  8132   49.9  49     3.0  8408   48.9  50     2.5  8174   43.5  50                               
 38   3.7  7700   51.3  50     3.3  8123   50.9  49     2.9  8277   50.2  50     2.4  8222   44.3  50                               
 42   3.8  8589   51.6  50     3.3  8389   51.2  49     2.9  8258   50.6  50     2.3  8397   43.9  50                               
 46   4.0  8271   52.5  50     3.5  8292   52.1  49     3.0  8245   51.4  50     2.5  7941   44.0  50                               
 50   4.0  7966   52.8  50     3.5  8305   52.4  49     2.8  8393   51.9  50     2.3  7381   44.6  50                               
 54   4.3  8256   53.1  50     3.6  8250   52.5  49     3.1  8424   52.1  50     2.6  8256   45.7  49                               
 58   4.3  8169   53.1  50     3.7  8130   52.8  49     3.0  8359   51.8  50     2.6  8173   45.6  49                               
 62   4.4  8192   53.9  49     3.7  7669   53.8  47     2.9  8240   52.4  50     2.7  7681   47.3  47                               
 66   4.4  7569   53.9  49     4.1  7735   53.8  47     3.2  8252   52.5  50     3.0  7400   48.1  46                               
 70   4.2  7773   53.5  49     3.8  7854   53.6  47     3.0  8295   52.0  50     3.0  7330   47.8  45                               
 74   4.3  7837   52.4  49     3.7  7575   53.6  45     2.8  8093   51.6  49     3.0  7258   46.6  45                               
 78   4.4  7951   52.5  49     3.9  7615   53.0  45     3.0  8107   51.6  48     2.9  7107   47.2  42                               
 82   4.5  7713   53.1  47     3.7  7031   53.4  44     3.0  7865   52.4  47     3.0  7003   46.2  42                               
 86   4.5  7370   53.2  45     3.8  6987   52.5  43     3.0  7183   50.4  46     2.4  6143   43.4  41                               
 90   4.5  7368   52.6  44     3.7  7026   52.0  42     2.8  7534   49.3  45     2.0  6711   41.4  40                               
 94   4.2  6477   51.5  43     3.9  6667   51.1  42     3.1  6417   48.7  42     2.6  5557   40.0  40                               
 98   4.1  6509   50.3  42     3.6  6868   50.4  41     2.9  6352   49.8  38     2.5  6181   39.6  37                               
102   4.3  6692   48.6  42     3.6  6713   49.1  40     3.1  6064   48.4  37     2.3  6038   37.3  36                               
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                 
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                     1.0%                     2.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.2  50                 18.3  50                 18.3  50                 18.3  50                               
  1   3.0  3434   18.2  50     2.8  3440   18.3  50     2.0  3334   18.3  50     1.1  3429   18.3  50                               
  2   2.8  4792   19.2  50     2.7  4735   19.1  50     2.0  4305   18.6  50     1.3  4845   17.0  50                               
  5   2.7  3448                2.6  3585                2.3  3234                1.9  3526                                          
  6   2.6  4887   22.7  50     2.7  4135   23.5  50     2.3  4914   22.2  50     1.9  4829   22.0  49                               
  9   2.8  3483                2.8  3493                2.4  3510                2.2  3464                                          
 10   2.6  4906   27.4  50     2.5  4931   27.8  50     2.2  4452   26.4  50     2.0  4632   26.4  49                               
 13   2.9  3634                2.8  3648                2.7  2907                2.5  2770                                          
 14   3.0  4802   32.7  50     2.5  4832   33.3  50     2.4  4761   32.3  50     2.2  3504   32.4  49                               
 17   2.7  3354                2.8  3146                2.5  3006                3.1  3285                                          
 18   2.5  4562   38.0  50     2.5  4388   38.4  50     2.3  4357   36.8  50     2.3  4833   36.6  49                               
 21   2.5  3648                2.3  3280                2.7  3305                2.4  3626                                          
 22   2.5  4727   43.0  50     2.9  4810   43.2  50     2.8  4760   41.1  50     2.3  4143   41.1  49                               
 25   2.4  3520                2.3  3550                2.2  3554                2.3  3473                                          
 26   2.5  4825   45.7  50     2.4  4810   46.3  50     2.2  4751   43.7  50     2.4  4289   44.3  49                               
 29   2.7  3453                2.6  3282                2.5  3519                2.6  3106                                          
 30   2.5  4756   48.1  49     2.5  4862   47.7  50     2.4  4841   46.1  50     2.5  4484   46.5  49                               
 33   2.7  3431                2.7  3495                2.7  3495                2.6  3410                                          
 34   2.5  4777   51.5  49     2.4  4850   51.1  50     2.3  4805   49.2  50     2.6  4601   49.9  48                               
 37   2.6  3493                2.6  3574                2.4  3589                2.5  3411                                          
 38   2.4  4655   54.3  49     2.4  4731   53.8  50     2.3  4700   52.6  50     2.4  4539   52.2  48                               
 41   2.3  3564                2.3  3632                2.4  3595                2.3  3443                                          
 42   2.4  4168   56.3  49     2.4  4676   55.9  50     2.7  4247   54.7  50     2.5  4574   54.5  48                               
 45   2.6  3394                2.4  3546                2.5  3540                2.6  3358                                          
 46   2.2  4854   57.7  49     2.7  4840   57.2  50     2.1  4537   55.8  50     2.0  4085   55.4  48                               
 49   2.4  3471                2.4  3512                2.2  3514                2.4  3385                                          
 50   2.3  4831   59.6  49     2.2  4998   58.5  50     2.1  4767   58.2  49     2.1  4716   57.2  48                               
 53   2.6  3433                2.5  3535                2.6  3474                2.5  3388                                          
 54   2.5  4891   60.6  49     2.2  4182   59.6  50     2.2  4876   59.2  49     2.2  4767   57.8  48                               
 57   2.9  3381                2.4  3455                2.4  3373                2.5  3282                                          
 58   2.7  4353   60.5  49     2.5  4744   60.4  50     2.3  4072   58.8  49     2.3  4685   57.0  47                               
 61   2.6  3641                2.4  3732                2.1  3575                2.3  3117                                          
 62   2.5  4485   61.3  49     2.6  4501   59.4  50     2.2  4432   59.5  48     2.2  3439   57.7  47                               
 65   2.7  3454                2.5  3557                2.4  2693                2.3  2620                                          
 66   2.5  4260   61.4  49     2.4  4836   60.0  50     2.3  4175   59.0  48     2.3  4495   57.7  46                               
 69   2.5  3281                2.4  3371                2.5  2765                2.2  2761                                          
 70   2.5  4789   60.4  49     2.3  4395   59.7  50     2.1  3975   57.8  47     2.0  3165   56.7  46                               
 73   2.6  3380                2.5  3472                2.2  3308                2.3  2843                                          
 74   4.2  4126   60.7  48     2.8  2688   59.2  49     2.5  2448   58.5  47     3.1  2362   56.4  43                               
 77   2.5  3451                2.4  3494                2.5  3302                2.6  2457                                          
 78   2.5  4641   61.3  48     2.1  4300   58.0  49     1.9  4446   58.8  46     1.9  3162   55.5  43                               
 81   2.8  3465                2.4  3371                2.4  3249                2.3  2749                                          
 82   2.5  4628   61.1  48     2.3  4088   60.2  47     2.6  4336   59.6  45     2.7  3094   56.6  37                               
 85   2.9  3431                2.5  3377                2.1  3138                2.4  2322                                          
 86   2.8  4507   59.7  47     2.6  4095   56.6  46     2.2  3757   56.9  43     2.3  2676   54.4  37                               
 89   2.9  3095                2.9  2925                2.3  2099                2.6  2493                                          
 90   2.9  4334   57.7  45     2.4  4076   53.9  46     2.5  3559   55.9  42     2.0  2664   50.5  37                               
 93   3.4  3051                3.0  3037                2.7  2631                2.0  2552                                          
 94   3.4  4232   55.4  43     2.5  3652   51.4  44     2.5  3320   53.7  42     1.8  2333   47.2  36                               
 97   3.1  2880                2.5  3078                2.5  2876                2.2  1666                                          
=========================================================================================================                           
                                                                                                                                   
                               DIAGNOSTIC TRAILER REPORT                                                                            
                               WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                 
                               CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL                                                      
=========================================================================================================                           
            0.0%                     1.0%                     2.0%                     4.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS  WATER HOURS  WGT   WGTS                             
==========================================================================================================                          
 98   3.5  3747   53.4  43     2.4  3664   51.0  43     2.4  3827   54.4  40     1.7  3326   45.7  35                               
101   3.9  2437                3.0  2653                3.1  2595                2.6  2202                                          
102   3.7  3742   52.4  39     2.6  3360   51.0  40     2.5  3752   53.2  38     2.0  3181   45.2  33                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.9                     22.2                     21.4                     20.9                                   
14 TO 52          48.7                     48.5                     47.1                     47.0                                   
 > 52             58.9                     57.0                     57.3                     53.7                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.