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TDMS Study 88031-06 Pathology Tables

NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01
Route: DOSED WATER                                                                                                Time: 09:37:34

                                                          Final#1/Mice




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  25265-71-8

       Lock Date:  04/20/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11           11            8            7                                     
    Moribund Sacrifice                                 2            1            4            6                                     
    Accidently Killed                                                                         4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           38           38           32                                     
    Natural Death                                                                             1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (49)                                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Adenomatous, Multiple                                                             1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Polyp Adenomatous                                             1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                                1 (2%)                                                          
      Sarcoma NOS                                                                1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                    1 (2%)       1 (2%)                                
      Hemangiosarcoma                                  2 (4%)                                                                       
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         6 (12%)      2 (4%)       1 (2%)       2 (4%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)                                             
      Hepatocellular Adenoma                           7 (14%)     11 (22%)     11 (22%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                 4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Mesentery                                1 (2%)       1 (2%)                                             
   Mesentery                                          (11)         (18)         (13)         (14)                                   
      Carcinoma NOS                                                              1 (8%)                                             
      Fibrosarcoma                                                               1 (8%)                                             
      Fibrosarcoma, Metastatic, Bone                                1 (6%)                                                          
      Liposarcoma                                                   1 (6%)                                                          
      Sarcoma                                                                    1 (8%)                                             
      Sarcoma NOS                                                   2 (11%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          2 (4%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Tissue NOS                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                                                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)                                 1 (2%)                                
   Pituitary Gland                                    (49)         (49)         (49)         (49)                                   
      Pars Distalis, Adenoma                           1 (2%)       3 (6%)       3 (6%)       3 (6%)                                
      Pars Intermedia, Carcinoma                                                              1 (2%)                                
   Thyroid Gland                                      (49)         (48)         (49)         (48)                                   
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicle, Adenoma                                             1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (49)         (50)                                   
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cystadenoma                                                   2 (4%)       2 (4%)       1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Deciduoma Benign                                                                        1 (2%)                                
      Polyp Stromal                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (5)          (3)          (1)          (2)                                    
      Mediastinal, Sarcoma, Metastatic, Mesentery                   1 (33%)                                                         
      Pancreatic, Sarcoma, Metastatic, Mesentery                    1 (33%)                                                         
   Lymph Node, Mandibular                             (48)         (45)         (48)         (48)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (48)         (49)         (49)                                   
      Hemangioma                                                                              1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Sarcoma NOS                                                                1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (49)         (49)         (48)         (50)                                   
      Carcinoma, Metastatic, Tissue NOS                1 (2%)                                                                       
      Hemangioma                                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma NOS                 2 (4%)       7 (14%)      2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (2)                                                                           
      Sarcoma                                          1 (50%)                                                                      
      Sarcoma NOS                                      1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    4 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Mesentery                                           1 (2%)                                             
      Carcinoma, Metastatic, Tissue NOS                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  2 (4%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)                                                          
      Mediastinum, Hemangiosarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (2)          (4)                                    
      Adenoma                                          1 (100%)     2 (67%)      2 (100%)     3 (75%)                               
      Carcinoma                                                     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)         (49)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Lymphoma Malignant                               5 (10%)      2 (4%)       2 (4%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          35          30          29                                       
     Total Primary Neoplasms                           49          46          44          42                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 22          24          22          21                                       
     Total Benign Neoplasms                            24          24          28          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          18          14          14                                       
     Total Malignant Neoplasms                         25          22          15          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6           4                                                   
     Total Metastatic Neoplasm                          5          10           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            8           10            6                                     
    Moribund Sacrifice                                 3            3            5            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           39           35           34                                     
    Natural Death                                      1                                                                            
  Missing                                                                                     1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Duodenum                          (50)         (49)         (50)         (49)                                   
      Hemangioma                                       1 (2%)                                                                       
      Polyp Adenomatous                                1 (2%)       2 (4%)                                                          
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)                                   
      Carcinoma                                        1 (2%)       2 (4%)       3 (6%)                                             
      Polyp Adenomatous                                1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hemangioma                                       1 (2%)       1 (2%)       2 (4%)                                             
      Hemangiosarcoma                                               3 (6%)       1 (2%)       2 (4%)                                
      Hepatoblastoma                                                             4 (8%)       1 (2%)                                
      Hepatocellular Carcinoma                        11 (22%)      7 (14%)      8 (16%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple               3 (6%)       3 (6%)       3 (6%)       7 (14%)                               
      Hepatocellular Adenoma                          10 (20%)     14 (28%)     14 (28%)      4 (8%)                                
      Hepatocellular Adenoma, Multiple                 7 (14%)      3 (6%)       6 (12%)      2 (4%)                                
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (8)          (10)         (1)                                                 
   Pancreas                                           (50)         (50)         (50)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
   Adrenal Medulla                                    (50)         (49)         (50)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (48)         (49)         (49)                                   
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Follicle, Adenoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
   Testes                                             (50)         (50)         (50)         (49)                                   
      Interstitial Cell, Adenoma                       3 (6%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (1)                                                                           
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (100%)                                                                     
   Lymph Node, Mesenteric                             (48)         (50)         (49)         (48)                                   
      Carcinoma, Metastatic, Intestine Large, Cecum                                           1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (46)         (45)         (47)         (44)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (49)                                   
      Pinna, Ear, Neural Crest Tumor                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (1)          (1)                                    
      Hepatoblastoma, Metastatic, Liver                                                       1 (100%)                              
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       9 (18%)      4 (8%)       4 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       3 (6%)       6 (12%)      4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)       2 (4%)       2 (4%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                                       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      6 (12%)      2 (4%)       4 (8%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (49)                                   
      Glands, Carcinoma                                                                       1 (2%)                                
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                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
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         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (4)          (1)                                    
      Adenoma                                          2 (67%)      3 (100%)     4 (100%)     1 (100%)                              
      Carcinoma                                        1 (33%)                                                                      
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                           1 (2%)                                                                       
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 05/15/01  
Route: DOSED WATER                                                                                                Time: 09:37:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          37          39          33                                       
     Total Primary Neoplasms                           54          57          62          38                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          23          26          11                                       
     Total Benign Neoplasms                            31          34          32          12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          19          26          25                                       
     Total Malignant Neoplasms                         22          22          30          26                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           6           3           6                                       
     Total Metastatic Neoplasm                          8           6           6           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1                                                               
     Total Uncertain Neoplasms                          1           1                                                               
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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