Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/3221

TDMS Study 88031-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 05/15/01       
EXPERIMENT: 88031 TEST: 06                                                                                     TIME: 09:44:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 25265-71-8      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            Final#1/Mice                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 05/15/01       
EXPERIMENT: 88031 TEST: 06                                                                                     TIME: 09:44:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 25265-71-8      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                DIPROPYLENE GLYCOL                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia Focal                                                                            
                                       Hypertrophy Focal                                                                            
Islets, Pancreatic                     Hyperplasia                                                                                  
Kidney                                 Metaplasia Osseous                                                                           
Liver                                  Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Mixed Cell Focus                                                                             
Preputial Gland                        Inflammation                                                                                 
Seminal Vesicle                        Atrophy                                                                                      
Stomach, Glandular                     Inflammation Chronic                                                                         
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Blood Vessel: Aorta                    Inflammation Chronic                                                                         
Brain                                  Hydrocephalus                                                                                
Liver                                  Infiltration Cellular Lymphocyte                                                             
Lung                                   Thrombosis                                                                                   
Lung: Bronchus                         Foreign Body                                                                                 
                                       Inflammation Acute                                                                           
Nose                                   Inflammation Acute                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   4/50 (8%)    1/50 (2%)    0/49 (0%)   |1/50 (2%)    1/50 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/45.94      4/44.10      1/45.14      0/41.99     |1/45.83      1/46.33      2/44.02      0/40.09      | 
|POLY-3 PERCENT (g) |     15.2%        9.1%         2.2%         0.0%        |2.2%         2.2%         4.5%         0.0%         | 
|TERMINAL (d)       |     7/40 (18%)   4/39 (10%)   1/35 (3%)    0/34 (0%)   |1/37 (3%)    1/38 (3%)    2/38 (5%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |728 (T)      728 (T)      728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004N**   P=0.274N     P=0.048N*    P=0.016N*   |P=0.398N     P=0.756N     P=0.509      P=0.523N     | 
|POLY 3             |     P=0.002N**   P=0.285N     P=0.032N*    P=0.011N*   |P=0.417N     P=0.758N     P=0.486      P=0.527N     | 
|POLY 1.5           |     P=0.002N**   P=0.280N     P=0.031N*    P=0.010N*   |P=0.402N     P=0.758N     P=0.490      P=0.518N     | 
|POLY 6             |     P=0.003N**   P=0.285N     P=0.034N*    P=0.012N*   |P=0.431N     P=0.759N     P=0.483      P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.004N**   P=0.274N     P=0.048N*    (e)         |P=0.398N     P=0.756N     P=0.509      (e)          | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.262N     P=0.030N*    P=0.007N**  |P=0.367N     P=0.753N     P=0.492      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  24/50 (48%)  23/50 (46%)  15/49 (31%) |3/50 (6%)    3/50 (6%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     28/45.94     24/44.49     23/46.38     15/42.07    |3/45.83      3/46.33      2/44.02      1/40.09      | 
|POLY-3 PERCENT (g) |     61.0%        54.0%        49.6%        35.7%       |6.6%         6.5%         4.5%         2.5%         | 
|TERMINAL (d)       |     28/40 (70%)  23/39 (59%)  20/35 (57%)  14/34 (41%) |3/37 (8%)    3/38 (8%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      619          518          710         |728 (T)      728 (T)      728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027N*    P=0.297N     P=0.431N     P=0.026N*   |P=0.226N     P=0.651N     P=0.488N     P=0.346N     | 
|POLY 3             |     P=0.009N**   P=0.320N     P=0.182N     P=0.012N*   |P=0.237N     P=0.657N     P=0.518N     P=0.355N     | 
|POLY 1.5           |     P=0.008N**   P=0.315N     P=0.191N     P=0.010N*   |P=0.224N     P=0.657N     P=0.513N     P=0.338N     | 
|POLY 6             |     P=0.010N*    P=0.306N     P=0.179N     P=0.014N*   |P=0.249N     P=0.659N     P=0.522N     P=0.370N     | 
|LOGISTIC REGRESSION|     P=0.014N*    P=0.327N     P=0.257N     P=0.026N*   |P=0.226N     P=0.651N     P=0.488N     P=0.346N     | 
|COCH-ARM / FISHERS |     P=0.007N**   P=0.274N     P=0.212N     P=0.009N**  |P=0.195N     P=0.661N     P=0.510N     P=0.309N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  46/50 (92%)  44/50 (88%)  42/49 (86%) |48/50 (96%)  49/50 (98%)  49/49 (100%) 48/50 (96%)  | 
|POLY-3 RATE (b)    |     47/49.12     46/48.55     44/49.09     42/47.13    |48/49.72     49/49.46     49/49.00     48/49.84     | 
|POLY-3 PERCENT (g) |     95.7%        94.7%        89.6%        89.1%       |96.6%        99.1%        100.0%       96.3%        | 
|TERMINAL (d)       |     40/40 (100%) 37/39 (95%)  31/35 (89%)  31/34 (91%) |36/37 (97%)  38/38 (100%) 38/38 (100%) 32/33 (97%)  | 
|FIRST INCIDENCE    |     416          405          518          416         |193          494          406          20           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.390      P=0.563      P=0.421      P=0.447     |P=0.121      P=0.576N     P=0.542      P=0.192      | 
|POLY 3             |     P=0.103N     P=0.609N     P=0.209N     P=0.182N    |P=0.531N     P=0.424      P=0.282      P=0.689N     | 
|POLY 1.5           |     P=0.093N     P=0.605N     P=0.226N     P=0.170N    |P=0.557N     P=0.455      P=0.261      P=0.691N     | 
|POLY 6             |     P=0.112N     P=0.574N     P=0.179N     P=0.188N    |P=0.496N     P=0.397      P=0.326      P=0.688N     | 
|LOGISTIC REGRESSION|     P=0.128N     P=0.663N     P=0.241N     P=0.224N    |P=0.621N     P=0.551      P=0.241      P=0.667N     | 
|COCH-ARM / FISHERS |     P=0.094N     P=0.500N     P=0.243N     P=0.151N    |P=0.590N     P=0.500      P=0.253      P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      2/44.00      0/45.14      0/41.99     |1/45.83      0/45.33      1/44.02      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |2.2%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    1/39 (3%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    0/37 (0%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          710          ---          ---         |728 (T)      ---          728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.440N     P=0.234      (e)          (e)         |P=0.426N     P=0.500N     P=0.756N     P=0.523N     | 
|POLY 3             |     P=0.422N     P=0.228      (e)          (e)         |P=0.426N     P=0.502N     P=0.752      P=0.527N     | 
|POLY 1.5           |     P=0.417N     P=0.228      (e)          (e)         |P=0.420N     P=0.502N     P=0.754      P=0.518N     | 
|POLY 6             |     P=0.427N     P=0.228      (e)          (e)         |P=0.431N     P=0.503N     P=0.750      P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.425N     P=0.228      (e)          (e)         |P=0.426N     (e)          P=0.756N     (e)          | 
|COCH-ARM / FISHERS |     P=0.408N     P=0.242      (e)          (e)         |P=0.405N     P=0.505N     P=0.747      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      0/46.33      0/44.12      2/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.505N     P=0.527N     P=0.532N    |P=0.037 *    (e)          (e)          P=0.213      | 
|POLY 3             |     P=0.298N     P=0.508N     P=0.504N     P=0.518N    |P=0.040 *    (e)          (e)          P=0.209      | 
|POLY 1.5           |     P=0.301N     P=0.506N     P=0.502N     P=0.513N    |P=0.042 *    (e)          (e)          P=0.218      | 
|POLY 6             |     P=0.296N     P=0.508N     P=0.507N     P=0.523N    |P=0.039 *    (e)          (e)          P=0.201      | 
|LOGISTIC REGRESSION|     P=0.327N     (e)          (e)          (e)         |(e)          (e)          (e)          P=0.213      | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.500N     P=0.500N     P=0.505N    |P=0.046 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta                                                                                                              | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |1/45.83      3/46.98      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         6.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |728 (T)      585          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.181N     P=0.318      P=0.495N     P=0.523N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.171N     P=0.314      P=0.508N     P=0.527N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.164N     P=0.312      P=0.504N     P=0.518N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.176N     P=0.317      P=0.510N     P=0.534N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.144N     P=0.288      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153N     P=0.309      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |4/50 (8%)    4/50 (8%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.94      0/44.10      0/45.14      0/41.99     |4/46.32      4/46.33      4/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |8.6%         8.6%         9.1%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |2/37 (5%)    4/38 (11%)   4/38 (11%)   0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |641          728 (T)      728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.129N     P=0.238N     P=0.262N     P=0.269N    |P=0.072N     P=0.629N     P=0.640N     P=0.088N     | 
|POLY 3             |     P=0.108N     P=0.241N     P=0.236N     P=0.253N    |P=0.083N     P=0.643N     P=0.616      P=0.081N     | 
|POLY 1.5           |     P=0.109N     P=0.240N     P=0.234N     P=0.247N    |P=0.072N     P=0.639N     P=0.628      P=0.074N     | 
|POLY 6             |     P=0.108N     P=0.241N     P=0.240N     P=0.258N    |P=0.094N     P=0.637      P=0.606      P=0.089N     | 
|LOGISTIC REGRESSION|     P=0.129N     (e)          (e)          (e)         |P=0.076N     P=0.639N     P=0.627      P=0.069N     | 
|COCH-ARM / FISHERS |     P=0.114N     P=0.242N     P=0.242N     P=0.247N    |P=0.054N     P=0.643N     P=0.643N     P=0.059N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      0/45.47      0/43.56      2/41.21      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.218      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.214      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.221      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.208      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.098      (e)          (e)          P=0.319      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain: Hypothalamus                                                                                                              | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      1/45.47      0/43.56      2/41.21      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    1/38 (3%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          728 (T)      ---          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.121      P=0.505      (e)          P=0.218      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.126      P=0.498      (e)          P=0.214      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.131      P=0.498      (e)          P=0.221      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.123      P=0.498      (e)          P=0.208      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.214      P=0.505      (e)          P=0.319      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.141      P=0.495      (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.50      1/44.10      0/45.14      1/42.07     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         2.3%         0.0%         2.4%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    1/39 (3%)    0/35 (0%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     556          729 (T)      ---          710         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.411N     P=0.513N     P=0.257N     P=0.552N    |                                                    | 
|POLY 3             |     P=0.374N     P=0.518N     P=0.244N     P=0.535N    |                                                    | 
|POLY 1.5           |     P=0.373N     P=0.514N     P=0.241N     P=0.525N    |                                                    | 
|POLY 6             |     P=0.378N     P=0.521N     P=0.250N     P=0.545N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.364N     P=0.478N     P=0.242N     P=0.472N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.500N     P=0.247N     P=0.508N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder: Epithelium                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    1/48 (2%)    0/49 (0%)    2/48 (4%)   |5/50 (10%)   1/50 (2%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.18      1/42.35      0/44.14      2/41.64     |5/45.97      1/46.33      1/43.56      1/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         4.8%        |10.9%        2.2%         2.3%         2.5%         | 
|TERMINAL (d)       |     0/39 (0%)    1/38 (3%)    0/34 (0%)    2/34 (6%)   |4/37 (11%)   1/38 (3%)    1/38 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |693          728 (T)      728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.119      P=0.495      (e)          P=0.209     |P=0.087N     P=0.101N     P=0.102N     P=0.137N     | 
|POLY 3             |     P=0.131      P=0.492      (e)          P=0.224     |P=0.082N     P=0.100N     P=0.114N     P=0.136N     | 
|POLY 1.5           |     P=0.134      P=0.493      (e)          P=0.229     |P=0.079N     P=0.099N     P=0.111N     P=0.124N     | 
|POLY 6             |     P=0.128      P=0.491      (e)          P=0.219     |P=0.084N     P=0.100N     P=0.116N     P=0.148N     | 
|LOGISTIC REGRESSION|     (e)          P=0.495      (e)          P=0.209     |P=0.097N     P=0.101N     P=0.115N     P=0.147N     | 
|COCH-ARM / FISHERS |     P=0.139      P=0.500      (e)          P=0.247     |P=0.072N     P=0.102N     P=0.107N     P=0.102N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder: Epithelium                                                                                                          | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/48 (2%)    0/49 (0%)    0/48 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.18      1/42.35      0/44.14      0/41.64     |1/45.83      0/46.33      0/43.56      0/40.09      | 
|POLY-3 PERCENT (g) |     4.5%         2.4%         0.0%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    1/38 (3%)    0/34 (0%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |728 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.117N     P=0.509N     P=0.269N     P=0.269N    |P=0.317N     P=0.495N     P=0.495N     P=0.523N     | 
|POLY 3             |     P=0.100N     P=0.515N     P=0.237N     P=0.250N    |P=0.294N     P=0.498N     P=0.510N     P=0.527N     | 
|POLY 1.5           |     P=0.100N     P=0.512N     P=0.235N     P=0.246N    |P=0.299N     P=0.498N     P=0.508N     P=0.518N     | 
|POLY 6             |     P=0.101N     P=0.515N     P=0.242N     P=0.255N    |P=0.289N     P=0.498N     P=0.511N     P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.117N     P=0.509N     (e)          (e)         |P=0.317N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.100N     P=0.500N     P=0.242N     P=0.247N    |P=0.306N     P=0.500N     P=0.505N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.94      0/44.10      1/45.14      0/41.99     |1/45.83      0/46.33      0/43.56      0/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         2.2%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    0/39 (0%)    1/35 (3%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |728 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.106N     P=0.126N     P=0.354N     P=0.151N    |P=0.317N     P=0.495N     P=0.495N     P=0.523N     | 
|POLY 3             |     P=0.087N     P=0.126N     P=0.312N     P=0.135N    |P=0.294N     P=0.498N     P=0.510N     P=0.527N     | 
|POLY 1.5           |     P=0.086N     P=0.125N     P=0.308N     P=0.131N    |P=0.299N     P=0.498N     P=0.508N     P=0.518N     | 
|POLY 6             |     P=0.088N     P=0.126N     P=0.318N     P=0.140N    |P=0.289N     P=0.498N     P=0.511N     P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.106N     (e)          P=0.354N     (e)         |P=0.317N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.088N     P=0.121N     P=0.309N     P=0.125N    |P=0.306N     P=0.500N     P=0.505N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    1/49 (2%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.94      1/44.10      1/45.14      1/41.99     |2/45.83      0/46.33      0/43.56      1/40.25      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         2.2%         2.4%        |4.4%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     2/40 (5%)    1/39 (3%)    1/35 (3%)    1/34 (3%)   |2/37 (5%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |728 (T)      ---          ---          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.466N     P=0.509N     P=0.547N     P=0.557N    |P=0.498N     P=0.232N     P=0.232N     P=0.547N     | 
|POLY 3             |     P=0.426N     P=0.514N     P=0.506N     P=0.531N    |P=0.460N     P=0.235N     P=0.249N     P=0.545N     | 
|POLY 1.5           |     P=0.422N     P=0.511N     P=0.503N     P=0.522N    |P=0.462N     P=0.235N     P=0.246N     P=0.531N     | 
|POLY 6             |     P=0.432N     P=0.515N     P=0.513N     P=0.540N    |P=0.457N     P=0.235N     P=0.250N     P=0.557N     | 
|LOGISTIC REGRESSION|     P=0.466N     P=0.509N     P=0.547N     P=0.557N    |P=0.500N     (e)          (e)          P=0.554N     | 
|COCH-ARM / FISHERS |     P=0.416N     P=0.500N     P=0.500N     P=0.508N    |P=0.462N     P=0.247N     P=0.253N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |2/50 (4%)    1/50 (2%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.96      0/44.10      1/45.45      0/41.99     |2/46.36      1/46.49      1/43.70      2/40.74      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         2.2%         0.0%        |4.3%         2.2%         2.3%         4.9%         | 
|TERMINAL (d)       |     1/40 (3%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     724          ---          645          ---         |570          687          693          565          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.213N     P=0.248N     P=0.528N     P=0.279N    |P=0.481      P=0.497N     P=0.513N     P=0.617      | 
|POLY 3             |     P=0.193N     P=0.247N     P=0.504N     P=0.258N    |P=0.510      P=0.499N     P=0.521N     P=0.646      | 
|POLY 1.5           |     P=0.191N     P=0.245N     P=0.502N     P=0.252N    |P=0.523      P=0.498N     P=0.515N     P=0.662      | 
|POLY 6             |     P=0.195N     P=0.247N     P=0.509N     P=0.264N    |P=0.499      P=0.501N     P=0.524N     P=0.633      | 
|LOGISTIC REGRESSION|     P=0.193N     P=0.246N     P=0.499N     P=0.268N    |P=0.611      P=0.536N     P=0.500N     P=0.660N     | 
|COCH-ARM / FISHERS |     P=0.191N     P=0.247N     P=0.500N     P=0.253N    |P=0.555      P=0.500N     P=0.508N     P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum: Peyer's Patch                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.94      1/44.10      3/45.14      0/41.99     |0/45.83      0/46.33      2/44.82      2/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         6.7%         0.0%        |0.0%         0.0%         4.5%         5.0%         | 
|TERMINAL (d)       |     1/40 (3%)    1/39 (3%)    3/35 (9%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    1/38 (3%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          484          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.466N     P=0.756      P=0.258      P=0.532N    |P=0.071      (e)          P=0.240      P=0.213      | 
|POLY 3             |     P=0.444N     P=0.751      P=0.299      P=0.518N    |P=0.064      (e)          P=0.232      P=0.209      | 
|POLY 1.5           |     P=0.433N     P=0.753      P=0.303      P=0.513N    |P=0.070      (e)          P=0.234      P=0.218      | 
|POLY 6             |     P=0.456N     P=0.751      P=0.292      P=0.523N    |P=0.058      (e)          P=0.231      P=0.201      | 
|LOGISTIC REGRESSION|     P=0.466N     P=0.756      P=0.258      (e)         |P=0.095      (e)          P=0.238      P=0.213      | 
|COCH-ARM / FISHERS |     P=0.416N     P=0.753N     P=0.309      P=0.505N    |P=0.086      (e)          P=0.247      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     40/50 (80%)  41/50 (82%)  39/50 (78%)  43/49 (88%) |31/50 (62%)  29/50 (58%)  29/50 (58%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     40/47.02     41/47.38     39/47.99     43/47.00    |31/46.78     29/47.87     29/45.99     33/45.82     | 
|POLY-3 PERCENT (g) |     85.1%        86.5%        81.3%        91.5%       |66.3%        60.6%        63.1%        72.0%        | 
|TERMINAL (d)       |     37/40 (93%)  35/39 (90%)  30/35 (86%)  31/34 (91%) |27/37 (73%)  25/38 (66%)  25/38 (66%)  23/33 (70%)  | 
|FIRST INCIDENCE    |     556          224          494          416         |570          494          543          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026 *    P=0.393      P=0.274      P=0.035 *   |P=0.111      P=0.361N     P=0.377N     P=0.186      | 
|POLY 3             |     P=0.230      P=0.539      P=0.407N     P=0.241     |P=0.243      P=0.357N     P=0.457N     P=0.351      | 
|POLY 1.5           |     P=0.214      P=0.517      P=0.442N     P=0.223     |P=0.253      P=0.370N     P=0.441N     P=0.355      | 
|POLY 6             |     P=0.273      P=0.578      P=0.377N     P=0.298     |P=0.246      P=0.345N     P=0.457N     P=0.362      | 
|LOGISTIC REGRESSION|     P=0.121      P=0.345      P=0.538N     P=0.078     |P=0.154      P=0.392N     P=0.519N     P=0.258      | 
|COCH-ARM / FISHERS |     P=0.205      P=0.500      P=0.500N     P=0.220     |P=0.330      P=0.419N     P=0.419N     P=0.418      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      2/44.57      1/45.65      0/41.99     |0/45.83      0/46.33      2/45.02      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.2%         0.0%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    1/39 (3%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          588          575          ---         |---          ---          340          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.492N     P=0.232      P=0.500      (e)         |P=0.581      (e)          P=0.245      (e)          | 
|POLY 3             |     P=0.490N     P=0.230      P=0.499      (e)         |P=0.515      (e)          P=0.233      (e)          | 
|POLY 1.5           |     P=0.482N     P=0.231      P=0.500      (e)         |P=0.541      (e)          P=0.236      (e)          | 
|POLY 6             |     P=0.499N     P=0.231      P=0.496      (e)         |P=0.492      (e)          P=0.231      (e)          | 
|LOGISTIC REGRESSION|     P=0.440N     P=0.256      P=0.455      (e)         |P=0.636N     (e)          P=0.216      (e)          | 
|COCH-ARM / FISHERS |     P=0.466N     P=0.247      P=0.500      (e)         |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   14/50 (28%)  10/50 (20%)  9/49 (18%)  |4/50 (8%)    7/50 (14%)   9/50 (18%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     7/45.94      14/45.32     10/45.78     9/42.93     |4/45.83      7/46.64      9/44.84      8/40.09      | 
|POLY-3 PERCENT (g) |     15.2%        30.9%        21.8%        21.0%       |8.7%         15.0%        20.1%        20.0%        | 
|TERMINAL (d)       |     7/40 (18%)   11/39 (28%)  7/35 (20%)   6/34 (18%)  |4/37 (11%)   6/38 (16%)   7/38 (18%)   8/33 (24%)   | 
|FIRST INCIDENCE    |     729 (T)      501          645          533         |728 (T)      643          599          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385      P=0.064      P=0.216      P=0.274     |P=0.102      P=0.277      P=0.125      P=0.123      | 
|POLY 3             |     P=0.472      P=0.061      P=0.293      P=0.336     |P=0.092      P=0.271      P=0.106      P=0.118      | 
|POLY 1.5           |     P=0.492      P=0.061      P=0.296      P=0.349     |P=0.113      P=0.270      P=0.110      P=0.136      | 
|POLY 6             |     P=0.456      P=0.064      P=0.286      P=0.326     |P=0.077      P=0.272      P=0.105      P=0.103      | 
|LOGISTIC REGRESSION|     P=0.482      P=0.059      P=0.270      P=0.322     |P=0.085      P=0.265      P=0.104      P=0.123      | 
|COCH-ARM / FISHERS |     P=0.526      P=0.070      P=0.298      P=0.376     |P=0.167      P=0.262      P=0.117      P=0.178      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.94      0/44.10      0/45.14      0/41.99     |1/45.83      3/46.65      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         0.0%         0.0%        |2.2%         6.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    2/38 (5%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |728 (T)      641          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058N     P=0.126N     P=0.146N     P=0.151N    |P=0.174N     P=0.316      P=0.495N     P=0.523N     | 
|POLY 3             |     P=0.043N*    P=0.126N     P=0.122N     P=0.135N    |P=0.171N     P=0.312      P=0.508N     P=0.527N     | 
|POLY 1.5           |     P=0.044N*    P=0.125N     P=0.120N     P=0.131N    |P=0.164N     P=0.311      P=0.504N     P=0.518N     | 
|POLY 6             |     P=0.043N*    P=0.126N     P=0.125N     P=0.140N    |P=0.177N     P=0.312      P=0.510N     P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.058N     (e)          (e)          (e)         |P=0.167N     P=0.307      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.048N*    P=0.121N     P=0.121N     P=0.125N    |P=0.153N     P=0.309      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/50 (76%)  37/50 (74%)  34/50 (68%)  36/49 (73%) |12/50 (24%)  8/50 (16%)   15/50 (30%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     38/46.76     37/44.60     34/45.79     36/44.72    |12/46.00     8/46.33      15/45.81     12/40.84     | 
|POLY-3 PERCENT (g) |     81.3%        83.0%        74.3%        80.5%       |26.1%        17.3%        32.8%        29.4%        | 
|TERMINAL (d)       |     37/40 (93%)  34/39 (87%)  32/35 (91%)  29/34 (85%) |11/37 (30%)  8/38 (21%)   12/38 (32%)  10/33 (30%)  | 
|FIRST INCIDENCE    |     416          661          616          451         |683          728 (T)      406          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168      P=0.613N     P=0.556      P=0.243     |P=0.244      P=0.203N     P=0.347      P=0.458      | 
|POLY 3             |     P=0.435N     P=0.526      P=0.272N     P=0.573N    |P=0.241      P=0.219N     P=0.319      P=0.459      | 
|POLY 1.5           |     P=0.429N     P=0.560      P=0.262N     P=0.549N    |P=0.278      P=0.218N     P=0.324      P=0.502      | 
|POLY 6             |     P=0.421N     P=0.549      P=0.295N     P=0.558N    |P=0.213      P=0.222N     P=0.319      P=0.424      | 
|LOGISTIC REGRESSION|     P=0.416      P=0.550      P=0.302N     P=0.461     |P=0.239      P=0.215N     P=0.305      P=0.407      | 
|COCH-ARM / FISHERS |     P=0.410N     P=0.500N     P=0.252N     P=0.477N    |P=0.378      P=0.227N     P=0.326      P=0.592N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.45      0/44.10      0/45.14      0/41.99     |0/45.83      0/46.33      1/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     575          ---          ---          ---         |---          ---          728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.127N     P=0.250N     P=0.254N     P=0.270N    |P=0.683      (e)          P=0.505      (e)          | 
|POLY 3             |     P=0.109N     P=0.249N     P=0.244N     P=0.260N    |P=0.635      (e)          P=0.492      (e)          | 
|POLY 1.5           |     P=0.111N     P=0.246N     P=0.240N     P=0.253N    |P=0.654      (e)          P=0.496      (e)          | 
|POLY 6             |     P=0.109N     P=0.251N     P=0.249N     P=0.267N    |P=0.617      (e)          P=0.490      (e)          | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.205N     P=0.240N     P=0.204N    |(e)          (e)          P=0.505      (e)          | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.247N     P=0.253N    |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.94      1/44.10      2/45.14      0/41.99     |0/45.83      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    1/39 (3%)    2/35 (6%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.509N     P=0.646      P=0.275N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.218N     P=0.514N     P=0.688      P=0.258N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.212N     P=0.511N     P=0.691      P=0.252N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.225N     P=0.515N     P=0.681      P=0.263N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.240N     P=0.509N     P=0.646      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.204N     P=0.500N     P=0.691N     P=0.253N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    2/50 (4%)    2/49 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.94      4/44.10      2/45.14      2/42.90     |0/45.83      1/46.65      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         9.1%         4.4%         4.7%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    4/39 (10%)   2/35 (6%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      582         |---          641          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.529N     P=0.325      P=0.646      P=0.648     |P=0.600N     P=0.504      (e)          (e)          | 
|POLY 3             |     P=0.487N     P=0.318      P=0.688      P=0.669     |P=0.573N     P=0.504      (e)          (e)          | 
|POLY 1.5           |     P=0.480N     P=0.323      P=0.691      P=0.675     |P=0.570N     P=0.503      (e)          (e)          | 
|POLY 6             |     P=0.494N     P=0.317      P=0.681      P=0.665     |P=0.574N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.478N     P=0.325      P=0.646      P=0.666N    |P=0.535N     P=0.466      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.466N     P=0.339      P=0.691N     P=0.684     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/49 (2%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      2/45.36      1/41.99     |3/45.83      1/46.33      2/44.39      1/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         2.4%        |6.6%         2.2%         4.5%         2.5%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    1/35 (3%)    1/34 (3%)   |3/37 (8%)    1/38 (3%)    1/38 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          672          729 (T)     |728 (T)      728 (T)      654          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.214      (e)          P=0.220      P=0.468     |P=0.320N     P=0.295N     P=0.492N     P=0.346N     | 
|POLY 3             |     P=0.219      (e)          P=0.234      P=0.482     |P=0.319N     P=0.301N     P=0.514N     P=0.355N     | 
|POLY 1.5           |     P=0.227      (e)          P=0.236      P=0.487     |P=0.308N     P=0.301N     P=0.509N     P=0.338N     | 
|POLY 6             |     P=0.210      (e)          P=0.231      P=0.477     |P=0.329N     P=0.302N     P=0.517N     P=0.370N     | 
|LOGISTIC REGRESSION|     P=0.229      (e)          P=0.238      P=0.468     |P=0.334N     P=0.295N     P=0.516N     P=0.346N     | 
|COCH-ARM / FISHERS |     P=0.241      (e)          P=0.247      P=0.495     |P=0.279N     P=0.309N     P=0.500N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    3/49 (6%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.94      1/44.10      0/45.14      3/42.57     |2/45.83      0/46.33      1/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         0.0%         7.1%        |4.4%         0.0%         2.3%         2.5%         | 
|TERMINAL (d)       |     2/40 (5%)    1/39 (3%)    0/35 (0%)    1/34 (3%)   |2/37 (5%)    0/38 (0%)    1/38 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          610         |728 (T)      ---          728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.289      P=0.509N     P=0.268N     P=0.439     |P=0.536N     P=0.232N     P=0.491N     P=0.540N     | 
|POLY 3             |     P=0.323      P=0.514N     P=0.241N     P=0.465     |P=0.522N     P=0.235N     P=0.513N     P=0.546N     | 
|POLY 1.5           |     P=0.326      P=0.511N     P=0.239N     P=0.474     |P=0.516N     P=0.235N     P=0.508N     P=0.531N     | 
|POLY 6             |     P=0.319      P=0.515N     P=0.245N     P=0.459     |P=0.526N     P=0.235N     P=0.517N     P=0.560N     | 
|LOGISTIC REGRESSION|     P=0.320      P=0.509N     (e)          P=0.483     |P=0.536N     (e)          P=0.491N     P=0.540N     | 
|COCH-ARM / FISHERS |     P=0.330      P=0.500N     P=0.247N     P=0.490     |P=0.500N     P=0.247N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  24/50 (48%)  31/50 (62%)  12/49 (24%) |5/50 (10%)   5/50 (10%)   2/50 (4%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |     26/46.76     24/45.34     31/46.76     12/42.07    |5/45.83      5/46.33      2/44.12      8/42.20      | 
|POLY-3 PERCENT (g) |     55.6%        52.9%        66.3%        28.5%       |10.9%        10.8%        4.5%         19.0%        | 
|TERMINAL (d)       |     25/40 (63%)  22/39 (56%)  27/35 (77%)  11/34 (32%) |5/37 (14%)   5/38 (13%)   2/38 (5%)    5/33 (15%)   | 
|FIRST INCIDENCE    |     416          491          494          710         |728 (T)      728 (T)      728 (T)      452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.024N*    P=0.472N     P=0.052      P=0.014N*   |P=0.156      P=0.615N     P=0.205N     P=0.218      | 
|POLY 3             |     P=0.009N**   P=0.481N     P=0.192      P=0.007N**  |P=0.175      P=0.623N     P=0.232N     P=0.223      | 
|POLY 1.5           |     P=0.007N**   P=0.474N     P=0.200      P=0.005N**  |P=0.185      P=0.622N     P=0.226N     P=0.238      | 
|POLY 6             |     P=0.013N*    P=0.467N     P=0.176      P=0.008N**  |P=0.168      P=0.625N     P=0.236N     P=0.211      | 
|LOGISTIC REGRESSION|     P=0.009N**   P=0.499N     P=0.177      P=0.009N**  |P=0.194      P=0.615N     P=0.205N     P=0.279      | 
|COCH-ARM / FISHERS |     P=0.005N**   P=0.421N     P=0.210      P=0.004N**  |P=0.213      P=0.630N     P=0.218N     P=0.277      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  28/50 (56%)  18/50 (36%)  11/49 (22%) |21/50 (42%)  13/50 (26%)  16/50 (32%)  17/50 (34%)  | 
|POLY-3 RATE (b)    |     15/46.03     28/46.05     18/46.69     11/43.50    |21/46.37     13/46.49     16/45.32     17/42.13     | 
|POLY-3 PERCENT (g) |     32.6%        60.8%        38.6%        25.3%       |45.3%        28.0%        35.3%        40.4%        | 
|TERMINAL (d)       |     14/40 (35%)  23/39 (59%)  15/35 (43%)  9/34 (27%)  |19/37 (51%)  12/38 (32%)  12/38 (32%)  13/33 (39%)  | 
|FIRST INCIDENCE    |     708          491          518          451         |599          689          484          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.145N     P=0.007 **   P=0.198      P=0.409N    |P=0.525      P=0.055N     P=0.192N     P=0.442N     | 
|POLY 3             |     P=0.059N     P=0.004 **   P=0.351      P=0.298N    |P=0.502N     P=0.062N     P=0.222N     P=0.399N     | 
|POLY 1.5           |     P=0.054N     P=0.004 **   P=0.347      P=0.286N    |P=0.467N     P=0.062N     P=0.213N     P=0.359N     | 
|POLY 6             |     P=0.067N     P=0.005 **   P=0.345      P=0.313N    |P=0.524N     P=0.063N     P=0.223N     P=0.429N     | 
|LOGISTIC REGRESSION|     P=0.067N     P=0.004 **   P=0.312      P=0.315N    |P=0.518      P=0.061N     P=0.243N     P=0.441N     | 
|COCH-ARM / FISHERS |     P=0.053N     P=0.007 **   P=0.335      P=0.266N    |P=0.371N     P=0.069N     P=0.204N     P=0.268N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |30/50 (60%)  39/50 (78%)  35/50 (70%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |30/46.26     39/48.30     35/45.82     30/41.72     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |64.9%        80.7%        76.4%        71.9%        | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |27/37 (73%)  34/38 (90%)  31/38 (82%)  27/33 (82%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |683          494          484          452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.381      P=0.053      P=0.227      P=0.275      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.380      P=0.058      P=0.153      P=0.308      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.507      P=0.053      P=0.172      P=0.397      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.269      P=0.060      P=0.143      P=0.229      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.260      P=0.038 *    P=0.096      P=0.159      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.324N     P=0.041 *    P=0.201      P=0.581N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  21/50 (42%)  20/50 (40%)  20/49 (41%) |36/50 (72%)  33/50 (66%)  35/50 (70%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     23/45.96     21/44.17     20/45.40     20/43.97    |36/45.83     33/47.06     35/45.21     34/43.06     | 
|POLY-3 PERCENT (g) |     50.0%        47.5%        44.1%        45.5%       |78.6%        70.1%        77.4%        79.0%        | 
|TERMINAL (d)       |     22/40 (55%)  20/39 (51%)  19/35 (54%)  16/34 (47%) |36/37 (97%)  31/38 (82%)  33/38 (87%)  29/33 (88%)  | 
|FIRST INCIDENCE    |     724          710          661          416         |728 (T)      543          543          452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.474      P=0.463N     P=0.571N     P=0.557     |P=0.212      P=0.171N     P=0.375N     P=0.383      | 
|POLY 3             |     P=0.360N     P=0.489N     P=0.356N     P=0.412N    |P=0.397      P=0.233N     P=0.552N     P=0.591      | 
|POLY 1.5           |     P=0.353N     P=0.475N     P=0.347N     P=0.401N    |P=0.463      P=0.261N     P=0.530N     P=0.568N     | 
|POLY 6             |     P=0.367N     P=0.489N     P=0.379N     P=0.416N    |P=0.354      P=0.198N     P=0.548N     P=0.572      | 
|LOGISTIC REGRESSION|     P=0.486N     P=0.491N     P=0.493N     P=0.496N    |P=0.112      P=0.275N     P=0.494      P=0.243      | 
|COCH-ARM / FISHERS |     P=0.347N     P=0.420N     P=0.343N     P=0.376N    |P=0.438N     P=0.333N     P=0.500N     P=0.414N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  20/50 (40%)  21/50 (42%)  7/49 (14%)  |14/50 (28%)  19/50 (38%)  21/50 (42%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     15/46.88     20/44.79     21/45.91     7/41.99     |14/46.24     19/46.64     21/44.12     15/42.53     | 
|POLY-3 PERCENT (g) |     32.0%        44.7%        45.7%        16.7%       |30.3%        40.7%        47.6%        35.3%        | 
|TERMINAL (d)       |     13/40 (33%)  19/39 (49%)  18/35 (51%)  7/34 (21%)  |11/37 (30%)  18/38 (47%)  21/38 (55%)  11/33 (33%)  | 
|FIRST INCIDENCE    |     546          491          575          729 (T)     |683          643          728 (T)      501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075N     P=0.171      P=0.070      P=0.099N    |P=0.342      P=0.221      P=0.112      P=0.355      | 
|POLY 3             |     P=0.049N*    P=0.149      P=0.123      P=0.075N    |P=0.369      P=0.200      P=0.067      P=0.392      | 
|POLY 1.5           |     P=0.038N*    P=0.162      P=0.135      P=0.064N    |P=0.412      P=0.205      P=0.081      P=0.422      | 
|POLY 6             |     P=0.066N     P=0.141      P=0.105      P=0.089N    |P=0.334      P=0.192      P=0.055      P=0.367      | 
|LOGISTIC REGRESSION|     P=0.043N*    P=0.160      P=0.129      P=0.073N    |P=0.298      P=0.199      P=0.066      P=0.399      | 
|COCH-ARM / FISHERS |     P=0.028N*    P=0.201      P=0.149      P=0.050N    |P=0.530      P=0.198      P=0.104      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   5/50 (10%)   5/49 (10%)  |2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/46.63      5/44.35      5/45.86      5/42.95     |2/46.13      2/46.40      2/44.12      1/40.77      | 
|POLY-3 PERCENT (g) |     15.0%        11.3%        10.9%        11.6%       |4.3%         4.3%         4.5%         2.5%         | 
|TERMINAL (d)       |     4/40 (10%)   4/39 (10%)   3/35 (9%)    1/34 (3%)   |0/37 (0%)    1/38 (3%)    2/38 (5%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     603          661          616          582         |651          711          728 (T)      501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.404N     P=0.441N     P=0.482N    |P=0.423N     P=0.685N     P=0.691N     P=0.544N     | 
|POLY 3             |     P=0.392N     P=0.415N     P=0.391N     P=0.438N    |P=0.421N     P=0.692N     P=0.678      P=0.543N     | 
|POLY 1.5           |     P=0.381N     P=0.406N     P=0.385N     P=0.422N    |P=0.406N     P=0.690N     P=0.684      P=0.529N     | 
|POLY 6             |     P=0.403N     P=0.420N     P=0.404N     P=0.451N    |P=0.435N     P=0.694      P=0.672      P=0.556N     | 
|LOGISTIC REGRESSION|     P=0.370N     P=0.398N     P=0.376N     P=0.387N    |P=0.361N     P=0.695N     P=0.687      P=0.448N     | 
|COCH-ARM / FISHERS |     P=0.365N     P=0.380N     P=0.380N     P=0.394N    |P=0.373N     P=0.691N     P=0.691N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/50 (8%)    2/49 (4%)   |4/50 (8%)    10/50 (20%)  9/50 (18%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     3/45.94      3/44.10      4/45.14      2/42.41     |4/45.94      10/46.93     9/45.08      10/43.28     | 
|POLY-3 PERCENT (g) |     6.5%         6.8%         8.9%         4.7%        |8.7%         21.3%        20.0%        23.1%        | 
|TERMINAL (d)       |     3/40 (8%)    3/39 (8%)    4/35 (11%)   1/34 (3%)   |3/37 (8%)    8/38 (21%)   7/38 (18%)   5/33 (15%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      610         |699          543          406          501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.506N     P=0.652      P=0.427      P=0.565N    |P=0.072      P=0.086      P=0.127      P=0.056      | 
|POLY 3             |     P=0.459N     P=0.643      P=0.490      P=0.536N    |P=0.083      P=0.078      P=0.107      P=0.055      | 
|POLY 1.5           |     P=0.448N     P=0.647      P=0.496      P=0.527N    |P=0.090      P=0.078      P=0.111      P=0.059      | 
|POLY 6             |     P=0.470N     P=0.643      P=0.480      P=0.544N    |P=0.078      P=0.078      P=0.104      P=0.053      | 
|LOGISTIC REGRESSION|     P=0.472N     P=0.652      P=0.427      P=0.529N    |P=0.131      P=0.077      P=0.114      P=0.093      | 
|COCH-ARM / FISHERS |     P=0.431N     P=0.661N     P=0.500      P=0.510N    |P=0.117      P=0.074      P=0.117      P=0.074      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/49 (2%)   |3/50 (6%)    2/50 (4%)    4/49 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.94      1/44.10      1/45.23      1/42.15     |3/46.35      2/46.33      4/43.84      2/40.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.2%         2.4%        |6.5%         4.3%         9.1%         4.9%         | 
|TERMINAL (d)       |     0/40 (0%)    1/39 (3%)    0/35 (0%)    0/34 (0%)   |2/37 (5%)    2/38 (5%)    3/38 (8%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      708          688         |570          728 (T)      654          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      P=0.495      P=0.475      P=0.475     |P=0.545N     P=0.492N     P=0.503      P=0.556N     | 
|POLY 3             |     P=0.355      P=0.492      P=0.497      P=0.483     |P=0.549N     P=0.500N     P=0.470      P=0.556N     | 
|POLY 1.5           |     P=0.364      P=0.494      P=0.499      P=0.488     |P=0.527N     P=0.498N     P=0.477      P=0.538N     | 
|POLY 6             |     P=0.347      P=0.492      P=0.493      P=0.479     |P=0.567N     P=0.504N     P=0.466      P=0.574N     | 
|LOGISTIC REGRESSION|     P=0.367      P=0.495      P=0.498      P=0.499     |P=0.454N     P=0.505N     P=0.489      P=0.437N     | 
|COCH-ARM / FISHERS |     P=0.379      P=0.500      P=0.500      P=0.495     |P=0.480N     P=0.500N     P=0.489      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/49 (2%)   |1/50 (2%)    3/50 (6%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.94      1/44.10      1/45.14      1/41.99     |1/45.83      3/46.65      0/43.56      2/41.06      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.2%         2.4%        |2.2%         6.4%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/40 (0%)    1/39 (3%)    1/35 (3%)    1/34 (3%)   |1/37 (3%)    2/38 (5%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |728 (T)      641          ---          228          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341      P=0.495      P=0.473      P=0.468     |P=0.514      P=0.316      P=0.495N     P=0.474      | 
|POLY 3             |     P=0.354      P=0.492      P=0.496      P=0.482     |P=0.515      P=0.312      P=0.510N     P=0.462      | 
|POLY 1.5           |     P=0.363      P=0.494      P=0.498      P=0.487     |P=0.529      P=0.311      P=0.508N     P=0.475      | 
|POLY 6             |     P=0.344      P=0.492      P=0.493      P=0.477     |P=0.503      P=0.312      P=0.511N     P=0.449      | 
|LOGISTIC REGRESSION|     (e)          P=0.495      P=0.473      P=0.468     |P=0.567N     P=0.307      (e)          P=0.612      | 
|COCH-ARM / FISHERS |     P=0.379      P=0.500      P=0.500      P=0.495     |P=0.555      P=0.309      P=0.505N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Focal Osseous                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      2/45.54      1/41.99     |0/45.83      0/46.33      0/43.56      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    1/35 (3%)    1/34 (3%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          616          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.216      (e)          P=0.230      P=0.468     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.218      (e)          P=0.235      P=0.482     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.227      (e)          P=0.237      P=0.487     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.210      (e)          P=0.232      P=0.477     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.241      (e)          P=0.237      P=0.468     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.241      (e)          P=0.247      P=0.495     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |3/50 (6%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.41      0/44.10      1/45.14      0/41.99     |3/46.91      0/46.33      0/43.56      0/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         0.0%        |6.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    1/35 (3%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     592          ---          729 (T)      ---         |193          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.432N     P=0.513N     P=0.746      P=0.523N    |P=0.053N     P=0.123N     P=0.124N     P=0.144N     | 
|POLY 3             |     P=0.415N     P=0.510N     P=0.754      P=0.520N    |P=0.044N*    P=0.121N     P=0.132N     P=0.150N     | 
|POLY 1.5           |     P=0.412N     P=0.508N     P=0.757      P=0.514N    |P=0.045N*    P=0.120N     P=0.130N     P=0.140N     | 
|POLY 6             |     P=0.419N     P=0.512N     P=0.749      P=0.526N    |P=0.044N*    P=0.122N     P=0.134N     P=0.159N     | 
|LOGISTIC REGRESSION|     P=0.396N     P=0.429N     P=0.762      P=0.424N    |P=0.016N*    P=0.187N     P=0.110N     P=0.056N     | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.500N     P=0.753N     P=0.505N    |P=0.048N*    P=0.121N     P=0.125N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/50 (8%)    3/49 (6%)   |3/50 (6%)    1/50 (2%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.52      3/44.10      4/45.14      3/42.25     |3/46.15      1/46.33      1/43.56      1/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         6.8%         8.9%         7.1%        |6.5%         2.2%         2.3%         2.5%         | 
|TERMINAL (d)       |     2/40 (5%)    3/39 (8%)    4/35 (11%)   2/34 (6%)   |2/37 (5%)    1/38 (3%)    1/38 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     546          729 (T)      729 (T)      661         |641          728 (T)      728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.469      P=0.645      P=0.435      P=0.592     |P=0.277N     P=0.298N     P=0.306N     P=0.356N     | 
|POLY 3             |     P=0.506      P=0.637      P=0.484      P=0.617     |P=0.269N     P=0.304N     P=0.326N     P=0.357N     | 
|POLY 1.5           |     P=0.522      P=0.644      P=0.492      P=0.630     |P=0.261N     P=0.303N     P=0.321N     P=0.340N     | 
|POLY 6             |     P=0.490      P=0.634      P=0.470      P=0.605     |P=0.274N     P=0.306N     P=0.330N     P=0.374N     | 
|LOGISTIC REGRESSION|     P=0.520      P=0.660      P=0.499      P=0.664     |P=0.282N     P=0.303N     P=0.318N     P=0.346N     | 
|COCH-ARM / FISHERS |     P=0.547      P=0.661N     P=0.500      P=0.651     |P=0.243N     P=0.309N     P=0.316N     P=0.309N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchus                                                                                                                   | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      0/46.33      0/43.56      4/42.44      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         9.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.002 **   (e)          (e)          P=0.051      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.002 **   (e)          (e)          P=0.051      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.002 **   (e)          (e)          P=0.053      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.002 **   (e)          (e)          P=0.050      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.012 *    (e)          (e)          P=0.103      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.003 **   (e)          (e)          P=0.059      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchus                                                                                                                   | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |1/45.93      0/46.33      0/43.56      4/42.44      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         0.0%         9.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |704          ---          ---          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.020 *    P=0.500N     P=0.505N     P=0.146      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.024 *    P=0.498N     P=0.511N     P=0.156      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.024 *    P=0.498N     P=0.508N     P=0.161      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.023 *    P=0.499N     P=0.512N     P=0.152      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.068      P=0.500N     P=0.507N     P=0.262      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.028 *    P=0.500N     P=0.505N     P=0.181      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/49 (2%)    0/48 (0%)   |0/48 (0%)    1/48 (2%)    0/49 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/44.61      0/44.10      1/44.38      0/41.60     |0/43.86      1/44.33      0/43.82      2/39.79      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |0.0%         2.3%         0.0%         5.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    1/35 (3%)    0/34 (0%)   |0/36 (0%)    1/36 (3%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          728 (T)      ---          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.673      (e)          P=0.473      (e)         |P=0.119      P=0.500      (e)          P=0.211      | 
|POLY 3             |     P=0.670      (e)          P=0.499      (e)         |P=0.127      P=0.502      (e)          P=0.216      | 
|POLY 1.5           |     P=0.679      (e)          P=0.502      (e)         |P=0.132      P=0.502      (e)          P=0.224      | 
|POLY 6             |     P=0.660      (e)          P=0.494      (e)         |P=0.124      P=0.501      (e)          P=0.210      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.473      (e)         |P=0.119      P=0.500      (e)          P=0.216      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.505      (e)         |P=0.143      P=0.500      (e)          P=0.253      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/49 (2%)    0/48 (0%)   |2/48 (4%)    0/48 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/44.61      0/44.10      1/44.38      0/41.60     |2/43.86      0/44.33      1/44.47      0/39.63      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.6%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    1/35 (3%)    0/34 (0%)   |2/36 (6%)    0/36 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |728 (T)      ---          515          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.673      (e)          P=0.473      (e)         |P=0.201N     P=0.238N     P=0.490N     P=0.258N     | 
|POLY 3             |     P=0.670      (e)          P=0.499      (e)         |P=0.197N     P=0.235N     P=0.495N     P=0.260N     | 
|POLY 1.5           |     P=0.679      (e)          P=0.502      (e)         |P=0.194N     P=0.235N     P=0.494N     P=0.252N     | 
|POLY 6             |     P=0.660      (e)          P=0.494      (e)         |P=0.199N     P=0.235N     P=0.495N     P=0.268N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.473      (e)         |P=0.158N     (e)          P=0.491N     (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.505      (e)         |P=0.184N     P=0.247N     P=0.492N     P=0.242N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |2/5 (40%)    0/3 (0%)     0/1 (0%)     0/2 (0%)     | 
|POLY-3 RATE (b)    |     0/0.98       0/0.00       0/0.00       0/0.00      |2/4.99       0/2.47       0/0.29       0/2.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |40.1%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |1/3 (33%)    0/1 (0%)     0/0 (0%)     0/2 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |704          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.175N     P=0.353N     P=0.505N     P=0.304N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.320N     P=0.396N     P=0.772N     P=0.451N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.369N     P=0.725N     P=0.451N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.336N     P=0.442N     P=0.807N     P=0.450N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.258N     P=0.447N     (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.234N     P=0.357N     P=0.667N     P=0.476N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/8 (88%)    9/10 (90%)   1/1 (100%)   0/0 (0%)    |11/11 (100%) 13/18 (72%)  11/13 (85%)  13/14 (93%)  | 
|POLY-3 RATE (b)    |     7/8.00       9/9.03       1/1.00       0/0.00      |11/11.00     13/17.55     11/12.56     13/14.00     | 
|POLY-3 PERCENT (g) |     87.5%        99.7%        100.0%       0.0%        |100.0%       74.1%        87.6%        92.9%        | 
|TERMINAL (d)       |     7/8 (88%)    8/8 (100%)   0/0 (0%)     0/0 (0%)    |9/9 (100%)   10/13 (77%)  7/8 (88%)    9/10 (90%)   | 
|FIRST INCIDENCE    |     729 (T)      710          727          ---         |570          494          515          452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.649      P=0.240      P=0.479      P=1.000     |P=0.250      P=0.433N     P=0.499      P=0.427      | 
|POLY 3             |     (e)          P=0.487      P=0.878      (e)         |P=0.499      P=0.080N     P=0.342N     P=0.548N     | 
|POLY 1.5           |     (e)          P=0.536      P=0.878      (e)         |P=0.484      P=0.075N     P=0.304N     P=0.548N     | 
|POLY 6             |     (e)          P=0.477      P=0.878      (e)         |P=0.525      P=0.090N     P=0.409N     P=0.548N     | 
|LOGISTIC REGRESSION|     P=0.747      P=0.469      (e)          (e)         |P=0.478      P=0.071N     P=0.317N     (e)          | 
|COCH-ARM / FISHERS |     P=0.828      P=0.706      P=0.889      P=1.000     |P=0.470      P=0.072N     P=0.283N     P=0.560N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      0/45.47      0/44.12      3/41.94      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         7.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.010 *    (e)          (e)          P=0.108      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.010 *    (e)          (e)          P=0.103      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.010 *    (e)          (e)          P=0.108      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.010 *    (e)          (e)          P=0.101      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.035 *    (e)          (e)          P=0.183      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.012 *    (e)          (e)          P=0.121      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    0/50 (0%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |3/46.00      0/46.33      5/44.12      2/40.09      | 
|POLY-3 PERCENT (g) |                                                        |6.5%         0.0%         11.3%        5.0%         | 
|TERMINAL (d)       |                                                        |2/37 (5%)    0/38 (0%)    5/38 (13%)   2/33 (6%)    | 
|FIRST INCIDENCE    |                                                        |683          ---          728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.482      P=0.120N     P=0.365      P=0.560N     | 
|POLY 3             |                                                        |P=0.453      P=0.117N     P=0.334      P=0.562N     | 
|POLY 1.5           |                                                        |P=0.481      P=0.117N     P=0.343      P=0.542N     | 
|POLY 6             |                                                        |P=0.428      P=0.118N     P=0.326      P=0.581N     | 
|LOGISTIC REGRESSION|                                                        |P=0.452      P=0.119N     P=0.330      P=0.579N     | 
|COCH-ARM / FISHERS |                                                        |P=0.544      P=0.121N     P=0.357      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  11/50 (22%)  15/50 (30%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |                                                        |12/45.83     11/46.92     15/45.21     14/41.04     | 
|POLY-3 PERCENT (g) |                                                        |26.2%        23.5%        33.2%        34.1%        | 
|TERMINAL (d)       |                                                        |12/37 (32%)  10/38 (26%)  13/38 (34%)  12/33 (36%)  | 
|FIRST INCIDENCE    |                                                        |728 (T)      543          543          501          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.164      P=0.470N     P=0.347      P=0.279      | 
|POLY 3             |                                                        |P=0.169      P=0.474N     P=0.308      P=0.284      | 
|POLY 1.5           |                                                        |P=0.202      P=0.479N     P=0.315      P=0.321      | 
|POLY 6             |                                                        |P=0.146      P=0.470N     P=0.309      P=0.255      | 
|LOGISTIC REGRESSION|                                                        |P=0.153      P=0.491N     P=0.280      P=0.231      | 
|COCH-ARM / FISHERS |                                                        |P=0.293      P=0.500N     P=0.326      P=0.410      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/46.56      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |                                                        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |                                                        |599          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.133N     P=0.242N     P=0.255N     P=0.289N     | 
|POLY 3             |                                                        |P=0.110N     P=0.238N     P=0.249N     P=0.272N     | 
|POLY 1.5           |                                                        |P=0.111N     P=0.237N     P=0.244N     P=0.260N     | 
|POLY 6             |                                                        |P=0.107N     P=0.241N     P=0.254N     P=0.284N     | 
|LOGISTIC REGRESSION|                                                        |P=0.085N     P=0.276N     P=0.231N     P=0.199N     | 
|COCH-ARM / FISHERS |                                                        |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/48 (6%)    2/49 (4%)    1/49 (2%)   |6/49 (12%)   8/49 (16%)   6/49 (12%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     3/45.41      3/42.52      2/44.14      1/41.99     |6/46.13      8/45.47      6/43.56      5/40.44      | 
|POLY-3 PERCENT (g) |     6.6%         7.1%         4.5%         2.4%        |13.0%        17.6%        13.8%        12.4%        | 
|TERMINAL (d)       |     3/40 (8%)    3/39 (8%)    2/34 (6%)    1/34 (3%)   |5/37 (14%)   8/38 (21%)   6/38 (16%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |641          728 (T)      728 (T)      452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.251N     P=0.652      P=0.574N     P=0.365N    |P=0.455N     P=0.407      P=0.608N     P=0.594N     | 
|POLY 3             |     P=0.213N     P=0.632      P=0.513N     P=0.334N    |P=0.450N     P=0.375      P=0.580      P=0.591N     | 
|POLY 1.5           |     P=0.205N     P=0.636      P=0.506N     P=0.323N    |P=0.420N     P=0.380      P=0.593      P=0.565N     | 
|POLY 6             |     P=0.224N     P=0.632      P=0.525N     P=0.345N    |P=0.475N     P=0.370      P=0.572      P=0.614N     | 
|LOGISTIC REGRESSION|     P=0.251N     P=0.652      P=0.574N     P=0.365N    |P=0.433N     P=0.380      P=0.583      P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.192N     P=0.651      P=0.500N     P=0.309N    |P=0.345N     P=0.387      P=0.620N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  32/50 (64%)  34/50 (68%)  34/49 (69%) |                                                    | 
|POLY-3 RATE (b)    |     31/47.25     32/45.40     34/49.31     34/44.74    |                                                    | 
|POLY-3 PERCENT (g) |     65.6%        70.5%        69.0%        76.0%       |                                                    | 
|TERMINAL (d)       |     27/40 (68%)  28/39 (72%)  22/35 (63%)  28/34 (82%) |                                                    | 
|FIRST INCIDENCE    |     556          501          494          416         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061      P=0.431      P=0.170      P=0.078     |                                                    | 
|POLY 3             |     P=0.176      P=0.388      P=0.446      P=0.186     |                                                    | 
|POLY 1.5           |     P=0.197      P=0.414      P=0.405      P=0.220     |                                                    | 
|POLY 6             |     P=0.157      P=0.378      P=0.487      P=0.159     |                                                    | 
|LOGISTIC REGRESSION|     P=0.150      P=0.383      P=0.333      P=0.154     |                                                    | 
|COCH-ARM / FISHERS |     P=0.232      P=0.500      P=0.338      P=0.287     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    0/50 (0%)    0/49 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     5/46.76      3/44.10      0/45.14      0/41.99     |                                                    | 
|POLY-3 PERCENT (g) |     10.7%        6.8%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     4/40 (10%)   3/39 (8%)    0/35 (0%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     416          729 (T)      ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.011N*    P=0.374N     P=0.045N*    P=0.047N*   |                                                    | 
|POLY 3             |     P=0.008N**   P=0.389N     P=0.034N*    P=0.041N*   |                                                    | 
|POLY 1.5           |     P=0.007N**   P=0.381N     P=0.032N*    P=0.038N*   |                                                    | 
|POLY 6             |     P=0.008N**   P=0.392N     P=0.036N*    P=0.044N*   |                                                    | 
|LOGISTIC REGRESSION|     P=0.007N**   P=0.349N     P=0.032N*    P=0.025N*   |                                                    | 
|COCH-ARM / FISHERS |     P=0.008N**   P=0.357N     P=0.028N*    P=0.030N*   |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/49 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/46.03      0/44.10      0/45.14      2/41.99     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         4.8%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    2/34 (6%)   |                                                    | 
|FIRST INCIDENCE    |     708          ---          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.212      P=0.510N     P=0.525N     P=0.445     |                                                    | 
|POLY 3             |     P=0.237      P=0.509N     P=0.504N     P=0.468     |                                                    | 
|POLY 1.5           |     P=0.239      P=0.507N     P=0.502N     P=0.477     |                                                    | 
|POLY 6             |     P=0.233      P=0.509N     P=0.508N     P=0.459     |                                                    | 
|LOGISTIC REGRESSION|     P=0.220      P=0.506N     P=0.502N     P=0.458     |                                                    | 
|COCH-ARM / FISHERS |     P=0.241      P=0.500N     P=0.500N     P=0.492     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      2/42.07     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.8%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    1/34 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          710         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.038 *    (e)          (e)          P=0.205     |                                                    | 
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.218     |                                                    | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.223     |                                                    | 
|POLY 6             |     P=0.041 *    (e)          (e)          P=0.213     |                                                    | 
|LOGISTIC REGRESSION|     P=0.039 *    (e)          (e)          P=0.213     |                                                    | 
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.242     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    0/50 (0%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.94      4/44.57      0/45.14      1/41.99     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         9.0%         0.0%         2.4%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    3/39 (8%)    0/35 (0%)    1/34 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          588          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.583N     P=0.061      (e)          P=0.468     |                                                    | 
|POLY 3             |     P=0.564N     P=0.056      (e)          P=0.482     |                                                    | 
|POLY 1.5           |     P=0.555N     P=0.057      (e)          P=0.487     |                                                    | 
|POLY 6             |     P=0.572N     P=0.057      (e)          P=0.477     |                                                    | 
|LOGISTIC REGRESSION|     P=0.545N     P=0.062      (e)          P=0.468     |                                                    | 
|COCH-ARM / FISHERS |     P=0.538N     P=0.059      (e)          P=0.495     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/49 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.94      1/44.10      2/45.45      0/41.99     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         4.4%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    1/39 (3%)    1/35 (3%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      645          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.756      P=0.472      P=0.532N    |                                                    | 
|POLY 3             |     P=0.393N     P=0.751      P=0.496      P=0.518N    |                                                    | 
|POLY 1.5           |     P=0.385N     P=0.753      P=0.499      P=0.513N    |                                                    | 
|POLY 6             |     P=0.402N     P=0.751      P=0.491      P=0.523N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.383N     P=0.756      P=0.500      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.753N     P=0.500      P=0.505N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  17/50 (34%)  14/50 (28%)  12/49 (24%) |29/50 (58%)  24/50 (48%)  25/50 (50%)  24/50 (48%)  | 
|POLY-3 RATE (b)    |     15/47.45     17/46.24     14/46.14     12/43.97    |29/46.21     24/47.19     25/46.76     24/44.38     | 
|POLY-3 PERCENT (g) |     31.6%        36.8%        30.3%        27.3%       |62.8%        50.9%        53.5%        54.1%        | 
|TERMINAL (d)       |     11/40 (28%)  12/39 (31%)  12/35 (34%)  7/34 (21%)  |28/37 (76%)  19/38 (50%)  20/38 (53%)  17/33 (52%)  | 
|FIRST INCIDENCE    |     416          224          494          451         |621          641          484          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391N     P=0.386      P=0.535      P=0.492N    |P=0.477N     P=0.168N     P=0.234N     P=0.416N     | 
|POLY 3             |     P=0.289N     P=0.379      P=0.536N     P=0.412N    |P=0.307N     P=0.166N     P=0.239N     P=0.262N     | 
|POLY 1.5           |     P=0.269N     P=0.388      P=0.519N     P=0.391N    |P=0.295N     P=0.177N     P=0.252N     P=0.253N     | 
|POLY 6             |     P=0.308N     P=0.380      P=0.566N     P=0.428N    |P=0.312N     P=0.151N     P=0.213N     P=0.263N     | 
|LOGISTIC REGRESSION|     P=0.225N     P=0.442      P=0.499N     P=0.325N    |P=0.392N     P=0.187N     P=0.327N     P=0.348N     | 
|COCH-ARM / FISHERS |     P=0.234N     P=0.415      P=0.500N     P=0.349N    |P=0.237N     P=0.212N     P=0.274N     P=0.212N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  12/50 (24%)  11/50 (22%)  13/49 (27%) |12/50 (24%)  10/50 (20%)  10/50 (20%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     11/47.71     12/46.96     11/48.72     13/45.05    |12/47.34     10/48.76     10/47.08     12/46.58     | 
|POLY-3 PERCENT (g) |     23.1%        25.6%        22.6%        28.9%       |25.4%        20.5%        21.2%        25.8%        | 
|TERMINAL (d)       |     5/40 (13%)   6/39 (15%)   2/35 (6%)    6/34 (18%)  |8/37 (22%)   3/38 (8%)    5/38 (13%)   1/33 (3%)    | 
|FIRST INCIDENCE    |     556          224          494          464         |497          494          406          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266      P=0.467      P=0.526      P=0.287     |P=0.361      P=0.399N     P=0.411N     P=0.461      | 
|POLY 3             |     P=0.324      P=0.483      P=0.573N     P=0.345     |P=0.469      P=0.375N     P=0.410N     P=0.575      | 
|POLY 1.5           |     P=0.335      P=0.487      P=0.579N     P=0.359     |P=0.470      P=0.382N     P=0.406N     P=0.572      | 
|POLY 6             |     P=0.312      P=0.482      P=0.575N     P=0.333     |P=0.475      P=0.365N     P=0.412N     P=0.585      | 
|LOGISTIC REGRESSION|     P=0.476      P=0.596N     P=0.563N     P=0.485     |P=0.256N     P=0.448N     P=0.357N     P=0.387N     | 
|COCH-ARM / FISHERS |     P=0.355      P=0.500      P=0.595N     P=0.385     |P=0.500      P=0.405N     P=0.405N     P=0.592N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    3/50 (6%)    1/49 (2%)   |7/50 (14%)   8/50 (16%)   6/50 (12%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/45.94      1/44.10      3/45.14      1/41.99     |7/45.83      8/46.33      6/44.70      7/40.85      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         6.7%         2.4%        |15.3%        17.3%        13.4%        17.1%        | 
|TERMINAL (d)       |     2/40 (5%)    1/39 (3%)    3/35 (9%)    1/34 (3%)   |7/37 (19%)   8/38 (21%)   5/38 (13%)   6/33 (18%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |728 (T)      728 (T)      543          452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.543N     P=0.509N     P=0.439      P=0.557N    |P=0.508      P=0.523      P=0.483N     P=0.528      | 
|POLY 3             |     P=0.506N     P=0.514N     P=0.492      P=0.531N    |P=0.509      P=0.509      P=0.519N     P=0.523      | 
|POLY 1.5           |     P=0.496N     P=0.511N     P=0.496      P=0.522N    |P=0.539      P=0.510      P=0.511N     P=0.552      | 
|POLY 6             |     P=0.517N     P=0.515N     P=0.483      P=0.540N    |P=0.483      P=0.507      P=0.522N     P=0.496      | 
|LOGISTIC REGRESSION|     P=0.543N     P=0.509N     P=0.439      P=0.557N    |P=0.493      P=0.523      P=0.528N     P=0.514      | 
|COCH-ARM / FISHERS |     P=0.482N     P=0.500N     P=0.500      P=0.508N    |P=0.500N     P=0.500      P=0.500N     P=0.613N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    3/49 (6%)   |4/50 (8%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.94      0/44.10      1/45.45      3/41.99     |4/47.52      1/46.33      1/44.12      2/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         2.2%         7.1%        |8.4%         2.2%         2.3%         5.0%         | 
|TERMINAL (d)       |     2/40 (5%)    0/39 (0%)    0/35 (0%)    3/34 (9%)   |1/37 (3%)    1/38 (3%)    1/38 (3%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          645          729 (T)     |193          728 (T)      728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198      P=0.244N     P=0.528N     P=0.426     |P=0.353N     P=0.182N     P=0.186N     P=0.386N     | 
|POLY 3             |     P=0.227      P=0.246N     P=0.504N     P=0.459     |P=0.344N     P=0.187N     P=0.202N     P=0.418N     | 
|POLY 1.5           |     P=0.231      P=0.245N     P=0.501N     P=0.471     |P=0.335N     P=0.184N     P=0.195N     P=0.393N     | 
|POLY 6             |     P=0.221      P=0.247N     P=0.509N     P=0.448     |P=0.351N     P=0.189N     P=0.208N     P=0.441N     | 
|LOGISTIC REGRESSION|     P=0.215      (e)          P=0.500N     P=0.426     |P=0.215N     P=0.258N     P=0.147N     P=0.234N     | 
|COCH-ARM / FISHERS |     P=0.235      P=0.247N     P=0.500N     P=0.490     |P=0.313N     P=0.181N     P=0.181N     P=0.339N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.03      0/44.10      0/45.14      0/41.99     |0/45.83      0/46.33      0/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/40 (3%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     708          ---          ---          ---         |---          ---          ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.248N     P=0.269N     P=0.275N    |P=0.181      (e)          (e)          P=0.477      | 
|POLY 3             |     P=0.110N     P=0.247N     P=0.241N     P=0.258N    |P=0.181      (e)          (e)          P=0.473      | 
|POLY 1.5           |     P=0.111N     P=0.245N     P=0.239N     P=0.252N    |P=0.187      (e)          (e)          P=0.482      | 
|POLY 6             |     P=0.109N     P=0.247N     P=0.246N     P=0.264N    |P=0.177      (e)          (e)          P=0.466      | 
|LOGISTIC REGRESSION|     P=0.122N     P=0.246N     P=0.244N     P=0.261N    |(e)          (e)          (e)          P=0.477      | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.247N     P=0.253N    |P=0.198      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/49 (4%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      2/45.97      2/42.49     |3/46.84      0/46.33      1/44.26      1/40.25      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         4.7%        |6.4%         0.0%         2.3%         2.5%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          575          610         |193          ---          693          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075      (e)          P=0.245      P=0.215     |P=0.337N     P=0.123N     P=0.313N     P=0.352N     | 
|POLY 3             |     P=0.075      (e)          P=0.237      P=0.220     |P=0.314N     P=0.121N     P=0.326N     P=0.362N     | 
|POLY 1.5           |     P=0.078      (e)          P=0.238      P=0.224     |P=0.309N     P=0.120N     P=0.320N     P=0.345N     | 
|POLY 6             |     P=0.072      (e)          P=0.236      P=0.217     |P=0.317N     P=0.121N     P=0.329N     P=0.376N     | 
|LOGISTIC REGRESSION|     P=0.095      (e)          P=0.207      P=0.256     |P=0.189N     P=0.185N     P=0.286N     P=0.208N     | 
|COCH-ARM / FISHERS |     P=0.083      (e)          P=0.247      P=0.242     |P=0.296N     P=0.121N     P=0.309N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.94      0/44.10      0/45.14      0/41.99     |1/45.83      1/46.33      1/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         0.0%         0.0%        |2.2%         2.2%         2.3%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    1/38 (3%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |728 (T)      728 (T)      728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058N     P=0.126N     P=0.146N     P=0.151N    |P=0.335N     P=0.756N     P=0.756N     P=0.523N     | 
|POLY 3             |     P=0.043N*    P=0.126N     P=0.122N     P=0.135N    |P=0.343N     P=0.758N     P=0.752      P=0.527N     | 
|POLY 1.5           |     P=0.044N*    P=0.125N     P=0.120N     P=0.131N    |P=0.333N     P=0.758N     P=0.756      P=0.518N     | 
|POLY 6             |     P=0.043N*    P=0.126N     P=0.125N     P=0.140N    |P=0.351N     P=0.759N     P=0.750      P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.058N     (e)          (e)          (e)         |P=0.335N     P=0.756N     P=0.756N     (e)          | 
|COCH-ARM / FISHERS |     P=0.048N*    P=0.121N     P=0.121N     P=0.125N    |P=0.311N     P=0.753N     P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    2/49 (4%)   |4/50 (8%)    2/50 (4%)    5/50 (10%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      3/44.10      0/45.14      2/41.99     |4/45.83      2/46.33      5/44.90      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         6.8%         0.0%         4.8%        |8.7%         4.3%         11.1%        0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    3/39 (8%)    0/35 (0%)    2/34 (6%)   |4/37 (11%)   2/38 (5%)    3/38 (8%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |728 (T)      728 (T)      576          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.297      P=0.117      (e)          P=0.203     |P=0.122N     P=0.324N     P=0.508      P=0.078N     | 
|POLY 3             |     P=0.317      P=0.111      (e)          P=0.218     |P=0.135N     P=0.332N     P=0.487      P=0.079N     | 
|POLY 1.5           |     P=0.327      P=0.113      (e)          P=0.223     |P=0.121N     P=0.332N     P=0.492      P=0.073N     | 
|POLY 6             |     P=0.308      P=0.111      (e)          P=0.212     |P=0.148N     P=0.333N     P=0.488      P=0.085N     | 
|LOGISTIC REGRESSION|     (e)          P=0.117      (e)          P=0.203     |P=0.116N     P=0.324N     P=0.491      (e)          | 
|COCH-ARM / FISHERS |     P=0.344      P=0.121      (e)          P=0.242     |P=0.095N     P=0.339N     P=0.500      P=0.059N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      1/47.02      0/44.12      2/41.06      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.1%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          494          ---          504          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.122      P=0.504      (e)          P=0.212      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.124      P=0.505      (e)          P=0.213      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.129      P=0.504      (e)          P=0.221      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.121      P=0.506      (e)          P=0.208      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.251      P=0.337      (e)          P=0.291      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.140      P=0.500      (e)          P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Epithelium                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      2/45.14      0/41.99     |0/45.83      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    2/35 (6%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560      (e)          P=0.209      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.557      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.571      (e)          P=0.236      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.545      (e)          P=0.229      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.209      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.591      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.94      2/44.10      0/45.14      0/41.99     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    2/39 (5%)    0/35 (0%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.218N     P=0.491      P=0.527N     P=0.532N    |                                                    | 
|POLY 3             |     P=0.200N     P=0.486      P=0.504N     P=0.518N    |                                                    | 
|POLY 1.5           |     P=0.196N     P=0.489      P=0.502N     P=0.513N    |                                                    | 
|POLY 6             |     P=0.203N     P=0.485      P=0.507N     P=0.523N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.218N     P=0.491      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.191N     P=0.500      P=0.500N     P=0.505N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    1/45 (2%)    0/47 (0%)    0/44 (0%)   |5/49 (10%)   1/49 (2%)    4/48 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.38      1/39.10      0/42.70      0/37.65     |5/45.35      1/45.88      4/44.04      1/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         0.0%         0.0%        |11.0%        2.2%         9.1%         2.5%         | 
|TERMINAL (d)       |     0/37 (0%)    1/34 (3%)    0/34 (0%)    0/30 (0%)   |5/37 (14%)   1/38 (3%)    3/38 (8%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |728 (T)      728 (T)      543          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.597N     P=0.483      (e)          (e)         |P=0.168N     P=0.096N     P=0.488N     P=0.130N     | 
|POLY 3             |     P=0.581N     P=0.484      (e)          (e)         |P=0.173N     P=0.099N     P=0.518N     P=0.132N     | 
|POLY 1.5           |     P=0.579N     P=0.487      (e)          (e)         |P=0.159N     P=0.099N     P=0.514N     P=0.120N     | 
|POLY 6             |     P=0.584N     P=0.482      (e)          (e)         |P=0.185N     P=0.099N     P=0.520N     P=0.145N     | 
|LOGISTIC REGRESSION|     (e)          P=0.483      (e)          (e)         |P=0.164N     P=0.096N     P=0.518N     P=0.130N     | 
|COCH-ARM / FISHERS |     P=0.573N     P=0.495      (e)          (e)         |P=0.132N     P=0.102N     P=0.513N     P=0.098N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)   |1/49 (2%)    1/48 (2%)    0/49 (0%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/45.94      1/44.10      0/45.14      0/41.99     |1/45.27      1/45.01      0/43.56      2/40.06      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |2.2%         2.2%         0.0%         5.0%         | 
|TERMINAL (d)       |     0/40 (0%)    1/39 (3%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    1/38 (3%)    0/38 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |728 (T)      728 (T)      ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.593N     P=0.495      (e)          (e)         |P=0.329      P=0.756N     P=0.495N     P=0.460      | 
|POLY 3             |     P=0.578N     P=0.492      (e)          (e)         |P=0.339      P=0.759      P=0.508N     P=0.457      | 
|POLY 1.5           |     P=0.576N     P=0.494      (e)          (e)         |P=0.348      P=0.759      P=0.505N     P=0.473      | 
|POLY 6             |     P=0.580N     P=0.492      (e)          (e)         |P=0.330      P=0.759      P=0.510N     P=0.443      | 
|LOGISTIC REGRESSION|     (e)          P=0.495      (e)          (e)         |P=0.329      P=0.756N     (e)          P=0.460      | 
|COCH-ARM / FISHERS |     P=0.571N     P=0.500      (e)          (e)         |P=0.362      P=0.747      P=0.500N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/26 (100%) 22/22 (100%) 20/20 (100%) 7/7 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)   | 
|POLY-3 RATE (b)    |     26/26.00     22/22.00     20/20.00     7/7.00      |0/0.00       0/0.00       0/0.00       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |0.0%         0.0%         0.0%         100.0%       | 
|TERMINAL (d)       |     24/24 (100%) 19/19 (100%) 13/13 (100%) 6/6 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     556          491          575          668         |---          ---          ---          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/45.83      1/46.33      2/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.2%         4.5%         2.5%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    1/38 (3%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |                                                        |---          728 (T)      728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.329      P=0.505      P=0.244      P=0.477      | 
|POLY 3             |                                                        |P=0.302      P=0.502      P=0.229      P=0.473      | 
|POLY 1.5           |                                                        |P=0.322      P=0.502      P=0.232      P=0.482      | 
|POLY 6             |                                                        |P=0.284      P=0.502      P=0.226      P=0.466      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.505      P=0.244      P=0.477      | 
|COCH-ARM / FISHERS |                                                        |P=0.366      P=0.500      P=0.247      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/15/01                           EXPERIMENT: 88031 TEST: 06                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIPROPYLENE GLYCOL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |38/50 (76%)  38/50 (76%)  39/50 (78%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |                                                        |38/47.63     38/48.38     39/46.06     39/44.91     | 
|POLY-3 PERCENT (g) |                                                        |79.8%        78.6%        84.7%        86.8%        | 
|TERMINAL (d)       |                                                        |31/37 (84%)  32/38 (84%)  36/38 (95%)  30/33 (91%)  | 
|FIRST INCIDENCE    |                                                        |570          494          484          452          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.093      P=0.511N     P=0.561      P=0.167      | 
|POLY 3             |                                                        |P=0.156      P=0.542N     P=0.356      P=0.254      | 
|POLY 1.5           |                                                        |P=0.223      P=0.539N     P=0.429      P=0.321      | 
|POLY 6             |                                                        |P=0.101      P=0.566N     P=0.266      P=0.191      | 
|LOGISTIC REGRESSION|                                                        |P=0.089      P=0.553N     P=0.339      P=0.180      | 
|COCH-ARM / FISHERS |                                                        |P=0.432      P=0.592N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).