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TDMS Study 88032-05 Pathology Tables

NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97
Route: GAVAGE                                                                                                     Time: 07:29:10

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  434-07-01

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All


































                                                              Page   1


NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|             
                                           | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                          X           X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  A  A  A  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X  X     X     X  X  X  X  X        X        X     X  X  X  X  X|             
      Clear Cell Focus                     |                                  X                          X            |             
      Eosinophilic Focus                   |             X  X                                               X  X  X   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X        X           X              X           X        X      |             
      Inflammation, Chronic Active         | 1     1     1     1     1        1           1     1           1        2|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                1                                                         |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |    3                 3                    3     4                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                            +|             
      Fat, Inflammation, Chronic Active    |                                                                         3|             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   2     1        1     1        2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2                                                                     |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Perforation                          |                                                 X                        |             
      Ulcer                                |    2                 3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration, Chronic    |             2        1        2  1           1     2  1     1  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|             
                                           | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  1                                       |             
      Angiectasis                          |                      2                                2  2  2        2  2|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                            2                                             |             
      Vacuolization Cytoplasmic            |    2                                      4     1  1                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                      3                       1           4  2     2     1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    3                                1                                    |             
      Pars Distalis, Angiectasis           |                                        4                                 |             
      Pars Distalis, Hyperplasia           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |    1                       1                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                                                  2  3      |             
      Inflammation, Chronic Active         |                                     1        1                       1  1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |             3                                   3  4                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Cervix, Cyst                         | 3                                                                        |             
      Endometrium, Cyst                    |                                  2                                       |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                       +                                            +|             
      Ectasia                              |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|             
                                           | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             1            |             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Hyperplasia, Focal                   |                                                                         3|             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                       2                    3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                       2     2  1        1  1  1     2  3  1      |             
      Galactocele                          |                                                                      3   |             
      Hyperplasia, Focal                   |                2                                                     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosclerosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   2                                         1     1      |             
      Mineralization                       |                1           1                                1        1   |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             1            |             
      Interstitium, Fibrosis               |    3                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                      +                        |             
      Lens, Mineralization                 |                                                 2                        |             
      Retina, Degeneration                 |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|             
                                           | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                                      |             
      Mineralization                       | 1              1  1  2  1     1  1  1  1  1        1     1  1        1  1|             
      Nephropathy                          |    1     1  1  1        1     1  1              3  3  1  1  1  2  1  1   |             
      Pigmentation, Hemosiderin            |    2                 2                    1                 1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7|            |
                                           | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|      L     |
                                           | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X|     37     |
      Clear Cell Focus                     |                X           X     X                                       |      5     |
      Eosinophilic Focus                   |                                                 X     X     X            |      8     |
      Fibrosis                             |                                                          2               |      1  2.0|
      Hematopoietic Cell Proliferation     |                            1              1                              |      2  1.0|
      Hepatodiaphragmatic Nodule           |                               X     X     X  X     X                    X|     12     |
      Inflammation, Chronic Active         |    1  1           1        1     1           1  1                        |     17  1.1|
      Mixed Cell Focus                     |                               X                             X            |      2     |
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                         4                                                |      1  4.0|
      Bile Duct, Hyperplasia               |                                                       2                  |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      | 3                                         2                    3         |      7  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                        +              +|   5        |
      Fat, Inflammation, Chronic Active    |                                                                         2|      2  2.5|
      Fat, Mineralization                  |                                                          3               |      1  3.0|
      Fat, Necrosis                        | 2                                                        3               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1                             1                                1      |      8  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Perforation                          |                                                                          |      1     |
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7|            |
                                           | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|      L     |
                                           | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Degeneration, Chronic    |    1        1  1  1  1  1  2  2  1        2  1  2  1     1  2     1  1   |     29  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Angiectasis                          |    2        2  2  2  2  2  2  3  2           2  2  2        2     2  2   |     21  2.0|
      Mineralization                       |                                           2                              |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3           1           3                          3         |      5  2.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              3                           |      1  3.0|
      Cyst                                 | 3  2                                                  3           2      |     10  2.3|
      Hemorrhage                           |                                                                2         |      1  2.0|
      Hyperplasia                          | 2                                                                        |      3  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             4                 4                 2                        |      6  3.0|
      Inflammation, Chronic Active         |       1                                                     1  1         |      7  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Periovarian Tissue, Cyst             |                                                                         1|      4  2.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           4                              |      1  4.0|
      Hydrometra                           |                2                       2  3                              |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7|            |
                                           | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|      L     |
                                           | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cervix, Cyst                         |                                                                          |      1  3.0|
      Endometrium, Cyst                    |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                +         |   4        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                               4  2                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                           2                              |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Lymphoid Follicle, Depletion Cellular|                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Atrophy                              |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          1  1  2  1  1  4  2  1  3  1  1  2        2     2        2  1  2|     27  1.7|
      Galactocele                          |                            2                                             |      2  2.5|
      Hyperplasia, Focal                   |                                           3                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosclerosis                       | 3                    3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7|            |
                                           | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|      L     |
                                           | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                1  1  1  1        1                                       |      8  1.1|
      Mineralization                       |                1        1     1        1  1     1  1  1  1        1  1   |     15  1.0|
      Pigmentation                         |       1                                                     2            |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                1                 4                                1      |      4  1.8|
      Interstitium, Fibrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Mineralization                 |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       | 1              1     1     1  1        1     1        1  1  1     1  1   |     27  1.0|
      Nephropathy                          |    1     1  1  1  1  1     2  1  1        3  1  1  1  2  1     1  1      |     32  1.3|
      Pigmentation, Hemosiderin            |                                                                1         |      5  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|             
                                           | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|             
                                           | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  A  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X  X     X  X        X  X  X  X  X     X  X  X  X     X|             
      Clear Cell Focus                     |                                                 X  X                     |             
      Cyst                                 |                                              3                           |             
      Eosinophilic Focus                   |    X           2     X     X                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                                X                                    |             
      Inflammation, Chronic Active         | 2  1        1              2                    1  1                     |             
      Mixed Cell Focus                     |                         X                    X              X            |             
      Necrosis                             |                         1  1                                             |             
      Regeneration                         |                   2                                                      |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |       2  3              2           2                    2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                          +            |             
      Fat, Inflammation, Chronic Active    |                                  2                          4            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinus, Atrophy                      |    2  1                                1              2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      Ulcer                                |             3                                                        3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration, Chronic    |    2  2  1        1     1  1  1     3  1  1  2  1  2  2  1  1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|             
                                           | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|             
                                           | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2           3     2                 2  2  2  2  2        2     2      |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hypertrophy                          |                               3                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Vacuolization Cytoplasmic            |       2                             2                                   2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     2        2                           |             
      Hyperplasia                          |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                         3|             
      Pars Distalis, Hyperplasia           |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            4                                             |             
      Hyperplasia                          |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2  3     2                        |             
      Inflammation, Chronic Active         | 1                                                  2           1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      DYSGENESIS                           |                            1                                             |             
      Corpus Luteum, Cyst                  |                                                          2               |             
      Follicle, Cyst                       |                                                 4                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   4                                                      |             
      Hydrometra                           |                                                                          |             
      Endometrium, Cyst                    | 2                                                                        |             
      Endometrium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|             
                                           | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|             
                                           | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                 X                        |             
      Congestion                           |                   2                                                      |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2                       3                       3|             
      Pigmentation, Hemosiderin            |                                                                2         |             
      Lymphoid Follicle, Depletion Cellular|                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1     1  2  2  2     1     2  1        1           1  1  1  1  2  1  1  2|             
      Galactocele                          |                                                                          |             
      Lobular, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosclerosis                       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                 1     2  2  1                                   2   |             
      Mineralization                       | 1              1           1  1           1     1     1     1     1      |             
      Necrosis                             |                                                                      2   |             
      Pigmentation                         |                2                                                         |             
      Alveolar Epithelium, Hyperplasia     |             2                                1              1            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|             
                                           | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|             
                                           | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Mineralization                 |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                         2                                                |             
      Mineralization                       | 1           1  1        1        1     1  1     1           1     1  1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          |          1     1           1  1        1     1  1           1  1  1     1|             
      Pigmentation, Hemosiderin            |       1  1                    1                          3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3                                                |             
      Inflammation, Chronic Active         |                1                             1                           |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2|            |
                                           | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3 MG/KG                                | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |    X                                   X        X                 X      |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X     X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X      |     40     |
      Clear Cell Focus                     |          X        X  X  X     X        X  X           X        X         |     11     |
      Cyst                                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |             X        X                                                   |      6  2.0|
      Hematopoietic Cell Proliferation     |                               1                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           | X                 X        X                 X                           |      6     |
      Inflammation, Chronic Active         |             1  1     1                          1  1           1  1      |     13  1.2|
      Mixed Cell Focus                     |                   X     X        X              X                        |      7     |
      Necrosis                             |                                                                          |      2  1.0|
      Regeneration                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |       2                 1                                               2|      3  1.7|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |       4                                                              2  1|      8  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                   +      |   3        |
      Fat, Inflammation, Chronic Active    |                                                                   2      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             2                                                            |      1  2.0|
      Acinus, Atrophy                      |       1                       4     1                                    |      7  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                      2   |      1  2.0|
      Mineralization                       |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2|            |
                                           | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3 MG/KG                                | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Degeneration, Chronic    | 2        1  1  1     1  1        2  1  1  1  1     1     2  1  1  2      |     34  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2  1     2  2  2  2  2        2  1     2  3  3  3  2           2  2      |     26  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hypertrophy                          | 3              1                                   4              3      |      5  2.8|
      Metaplasia, Osseous                  |                                     3                                    |      1  3.0|
      Vacuolization Cytoplasmic            |       3                                               2                  |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             2           2                    2  2  2        2     3      |      9  2.1|
      Hyperplasia                          |       2                                                  2               |      2  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                                                   2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia                          |                         2                                                |      1  2.0|
      Ultimobranchial Cyst                 |                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Cyst                                 |             3     2                          4                           |      6  2.7|
      Inflammation, Chronic Active         |                1                       1              1        1  2      |      8  1.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      DYSGENESIS                           |                                                                          |      1  1.0|
      Corpus Luteum, Cyst                  |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                         2|      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                  4        4  2     2                     |      4  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2|            |
                                           | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3 MG/KG                                | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Cyst                    |                                                                          |      1  2.0|
      Endometrium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 4                        |      1  4.0|
      Myelofibrosis                        |       2                          4                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                                        3                                 |      1  3.0|
      Hemorrhage                           |                                                          2               |      1  2.0|
      Inflammation, Suppurative            |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                                                                          |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     |                                  2                       2           1   |      6  2.2|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|  47        |
      Atrophy                              |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 3  1  1        2  1  2     1     1  1     1        2  2     2  3  2  2  1|     34  1.5|
      Galactocele                          |                         2                                                |      1  2.0|
      Lobular, Hyperplasia                 |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosclerosis                       |                         4                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2|            |
                                           | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3 MG/KG                                | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |          1  1           2        1                                1     1|     12  1.4|
      Mineralization                       | 1  1           1  1     1     1        1     1  1     1  1  1  1  1      |     23  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          2  1        1                 1                 1        1     1|     10  1.2|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Squamous                        |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          2                          3                                    |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
      Lens, Mineralization                 |                                                                   3      |      1  3.0|
      Retina, Degeneration                 |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Mineralization                       | 1  1  1  1  1  1  1  1     1  1  1  2  1  1        1  1  1     1     1   |     31  1.0|
      Necrosis                             |                                                                         3|      1  3.0|
      Nephropathy                          | 2  2     1     1  1  1  2     1  1              1  2  1     1  1        1|     26  1.2|
      Pigmentation, Hemosiderin            |       1                 1                                            2   |      7  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                             1            |      3  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  17                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|             
                                           | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 MG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                   X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |             X              X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X     X  X  X  X  X     X  X  X  X  X  X           X  X  X   |             
      Clear Cell Focus                     |                         X           X              X                 X   |             
      Degeneration, Cystic                 |                               1                                          |             
      Eosinophilic Focus                   |                         X                 X                              |             
      Hepatodiaphragmatic Nodule           |                                     X                                X   |             
      Inflammation, Chronic Active         | 1        1              1     1           1     1                        |             
      Mixed Cell Focus                     |    X              X                          X           X               |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                                                       1                  |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |       2        2  1                    2              1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +           +        +  +            |             
      Mineralization                       |                                                                          |             
      Fat, Inflammation, Chronic Active    |             2                       2           2        2  1            |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1                                                                     |             
      Acinus, Atrophy                      |    2                 3                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |       2        2                       3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                        4                                 |             
      Myocardium, Degeneration, Chronic    |    1     2  1        2  2  1  2  1  1     3  2  1  2     2  1  2     2   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|             
                                           | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 MG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2     2  1     1           1     1     1              1               |             
      Pigmentation                         | 2                                                                        |             
      Vacuolization Cytoplasmic            |       1  1  1  2     1           3     2        1     2  1        1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Hyperplasia                          |             1                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2                                2  2   |             
      Hemorrhage                           |                            3                                             |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |             3           3                                                |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                                                |             
      Inflammation, Chronic Active         |          1           3        1           1  1           2  1        1   |             
      Inflammation                         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      DYSGENESIS                           | 1  1     2  2  2  3  3  3  3  2  3     3  3  3  3  3     4     4  3  3   |             
      Follicle, Cyst                       |             2                                                            |             
      Periovarian Tissue, Cyst             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Hydrometra                           |          1                 1                                   1         |             
      Endometrium, Cyst                    |                         1  2                       1                     |             
      Endometrium, Hyperplasia, Cystic     |          2     1  2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|             
                                           | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 MG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ectasia                              |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                3                                                         |             
      Ectasia                              |             2        3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal                   |                               3                                          |             
      Necrosis                             |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|       2                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              | 3     2                          3     3        3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2        1        2     1  1  2  2                                   2|             
      Galactocele                          |                      3                                                   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Cyst, Squamous                       |                   4                                                      |             
      Inflammation, Chronic Active         |             2                 2                 1  1              1      |             
      Mineralization                       |    1     1        1     1  1  1  1     1  1        1     1  1  1  1  1  1|             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|             
                                           | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 MG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Metaplasia, Osseous                  |             2                                                            |             
      Mineralization                       |    1  2  1  2  1  1  1  1     1  1        1  1  1  1        1  1  1  1  1|             
      Nephropathy                          | 1  2     1  2     1     1  1  1     1     1  1  1  1     1     1  2  1  1|             
      Pigmentation, Hemosiderin            |                                  1                    2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2|            |
                                           | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    30 MG/KG                               | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Parasite Metazoan                    |                                        X                                 |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Parasite Metazoan                    |                X                          X     X                        |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X     X  X  X  X     X  X  X  X  X  X  X  X  X  X        X  X  X  X|     37     |
      Clear Cell Focus                     |                X                                                  X      |      6     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |    X                                                                     |      3     |
      Hepatodiaphragmatic Nodule           |          X                                            X                  |      4     |
      Inflammation, Chronic Active         |                1  1              1                                1      |     10  1.0|
      Mixed Cell Focus                     |                   X              X     X     X  X                        |      9     |
      Vacuolization Cytoplasmic, Focal     |                                     2                                    |      1  2.0|
      Bile Duct, Hyperplasia               |    1        1           1                                1  1            |      6  1.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      | 1                                                                        |      6  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                 +                 +     +  +                 +|  12        |
      Mineralization                       |                                                                         2|      1  2.0|
      Fat, Inflammation, Chronic Active    | 2                          2                 2        4                 2|     10  2.1|
      Fat, Mineralization                  | 2                                            1     1                     |      3  1.3|
      Fat, Necrosis                        |                                                    2                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                   1      |      2  1.0|
      Acinus, Atrophy                      |                   4                    2                 1               |      5  2.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                   1      |      1  1.0|
      Ulcer                                |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  22                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2|            |
                                           | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    30 MG/KG                               | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                          |      1  4.0|
      Myocardium, Degeneration, Chronic    | 1  2  2  1  2  2  2  2  1  3     2  2  2  2  2  2  1  2  2     2  2  2  2|     40  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                1  1                    2     1  1                 2  2   |     15  1.3|
      Pigmentation                         |                               1                                          |      2  1.5|
      Vacuolization Cytoplasmic            | 3  1     3        1     1  1                       1  1     1           1|     21  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                                               2           2            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  42        |
      Hyperplasia                          |                                              3                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                 2                        |      4  2.0|
      Hemorrhage                           |                         1                                                |      2  2.0|
      Hyperplasia                          |                                                                      2  2|      2  2.0|
      Mineralization                       |    2                                                                     |      1  2.0|
      Pars Distalis, Angiectasis           |                                        2                                 |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      2  3.0|
      Pars Nervosa, Developmental          |                                                                          |            |
          Malformation                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                              2  1                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  4        3           3                 2|      5  3.0|
      Inflammation, Chronic Active         |                   1           1        1                                 |     11  1.3|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      DYSGENESIS                           | 2  3  3  3  3  3  3     3  2     3  3  3  2  2  3  4  3  3  3  1  2  3  3|     43  2.7|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  23                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2|            |
                                           | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    30 MG/KG                               | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Periovarian Tissue, Cyst             |                               3                    3  3                  |      4  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      3                                                   |      2  2.5|
      Hydrometra                           |    2                                                           2         |      5  1.4|
      Endometrium, Cyst                    |                1  2     2                          1           2        2|      9  1.6|
      Endometrium, Hyperplasia, Cystic     |             1                                                            |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular                |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                          2           1   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                2                                                         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                         3  2                             3               |      3  2.7|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Necrosis                             | 2                                                                        |      1  2.0|
      Capsule, Fibrosis                    |                                           1                              |      1  1.0|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  44        |
      Atrophy                              |                               2                    2                     |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Dilatation                           |       2  2              1                          1           2         |     13  1.6|
      Galactocele                          |    2                                               2                     |      3  2.3|
      Hyperplasia, Focal                   |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Cyst                      |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  24                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2|            |
                                           | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    30 MG/KG                               | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst, Squamous                       |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                     1  1                                 |      7  1.3|
      Mineralization                       |    1  1     1  1  1        1  1  1  1  1  1     1  1     1  1     1     1|     33  1.0|
      Pigmentation                         |                                                                   1      |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                      2                 2                                3|      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                      2                                                   |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |    1        1  1  1     1     1  1  1  1  1  1  1     1     1     1     1|     35  1.1|
      Nephropathy                          | 1        2  1     1  1  1  1     1  1  1  1  2  2  1  1  2  1     2  1  2|     38  1.2|
      Pigmentation, Hemosiderin            | 3                                                        2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                             2            |      2  2.5|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  25                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|             
                                           | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|             
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                    X     X                    X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X  X  X  X        X  X  X     X  X  X  X  X  X     X  X  X  X|             
      Clear Cell Focus                     |    X                 X              X     X           X        X     X   |             
      Degeneration, Cystic                 |          1                                                               |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X  X                          X                             X  X  X   |             
      Inflammation, Chronic Active         |          1                                                               |             
      Mixed Cell Focus                     |       X              X                                   X               |             
      Necrosis                             |                                  1                                       |             
      Regeneration                         |                                  2                                       |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                      2                       1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +        +                       +           +  +  +      |             
      Fat, Inflammation, Chronic Active    |                2        3                       2           2  2  2      |             
      Fat, Mineralization                  |                1        2                       2                        |             
      Fat, Necrosis                        |                         2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       | 2                                                                        |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|             
                                           | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|             
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Degeneration, Chronic    |    2  1  2     2  3  2  3     2     2  2  1  2  2  1  1  2     2  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 2        1  1  1  1  1              1        1  1  1     1     1  1  1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1        4                          3  1     4              3  4   |             
      Vacuolization Cytoplasmic            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               4                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                  3                                       |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                               X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2                                       |             
      Ultimobranchial Cyst                 |                   3                    1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                                  |             
      Inflammation, Chronic Active         | 1                          2     1  1           2     1  1  1  1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      DYSGENESIS                           | 2  4  3  3  3  4  2  4  3  3  3  3  3  3  3  3  2  4  4  3  3  3  4  4  3|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                               2                                      3   |             
      Cervix, Angiectasis                  |                                                                2         |             
      Cervix, Cyst                         |                                                                2         |             
      Endometrium, Cyst                    |                                                    3     1               |             
      Endometrium, Hyperplasia, Cystic     |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|             
                                           | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|             
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                          2                              |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Angiectasis                          |                      4                                                   |             
      Hematopoietic Cell Proliferation     |                                  2                                2      |             
      Necrosis                             |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                    4     3                                 |             
      Inflammation                         |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1     1  1           1  2                          1        1        1   |             
      Galactocele                          |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Lobular, Hyperplasia                 |                            4                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parakeratosis                        |                                                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +                                                                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
      Hemorrhage                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2  1  1     1  1           1        1  2  3     2     3  1         |             
      Mineralization                       |    1     1     1     1        1  1  1     1  1     1  1  1        1     1|             
      Alveolar Epithelium, Hyperplasia     |                      3              1        1     2           2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|             
                                           | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|             
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                                                         |             
      Developmental Malformation           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 1  1     1     1     1           1     1  1  1  1  1        1  1  1  1  1|             
      Nephropathy                          | 2  2  2  1  1  2  1  2  1     2     2  1  1  2        3  2     2  1  2  1|             
      Pigmentation, Hemosiderin            |                                           1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7|            |
                             DAY ON TEST   | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2|            |
                                           | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    MG/KG                                  | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |    3                                                                     |      1  3.0|
      Ulcer                                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X     X        X     X  X                                   X            |     10     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  44        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X  X  X  X  X     X  X  X  X  X  X  X  X  X  X        X  X  X  X  X     X|     41     |
      Clear Cell Focus                     | X     X        X  X  X                                   X  X            |     14     |
      Degeneration, Cystic                 |       1                                      1                           |      3  1.0|
      Eosinophilic Focus                   |                      X                       X  X                        |      3     |
      Hepatodiaphragmatic Nodule           |                                                          X  X  X         |      9     |
      Inflammation, Chronic Active         | 1  1  1              1                                                   |      5  1.0|
      Mixed Cell Focus                     |       X           X     X        X                                       |      7     |
      Necrosis                             |                                                                          |      1  1.0|
      Regeneration                         |                                           2                              |      2  2.0|
      Centrilobular, Necrosis              |                                                                2         |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                          1               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +        +  +                       +               |  10        |
      Fat, Inflammation, Chronic Active    |                      2        2  2                       1               |     10  2.0|
      Fat, Mineralization                  |                      1                                   1               |      5  1.4|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |       1           1                                                      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
      Angiectasis                          |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  30                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7|            |
                             DAY ON TEST   | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2|            |
                                           | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    MG/KG                                  | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                 3                        |      2  2.5|
      Myocardium, Degeneration, Chronic    | 2  1  2  2  2  2  2  2  2  2  1  2  1  2  1  2  2  2  2  2  2  2  2  2  2|     45  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                            2     1                                      2|      3  1.7|
      Necrosis                             |                                                                3         |      1  3.0|
      Vacuolization Cytoplasmic            | 1  3  1  1  2  2     1  1  1  1  1  1  1     4  1  1  1  1  1  2  1     1|     36  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          3           1     1              1  2        1                  |     13  2.2|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  M  +  M  M  +  +  M  +  +  M  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia                          |                                           1                              |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
      Pars Nervosa, Developmental          |                                                                          |            |
          Malformation                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 3                        |      2  3.0|
      Inflammation, Chronic Active         |    1     1  1              1  1                    1  1     1     1      |     18  1.1|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      DYSGENESIS                           | 4     4  4  4  4  4  4  4  4  3  4  3  3  3  4  3  3  4  4  4  4  4  3  4|     49  3.4|
      Follicle, Cyst                       |             4                                                            |      1  4.0|
      Periovarian Tissue, Cyst             |                            3        3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  31                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7|            |
                             DAY ON TEST   | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2|            |
                                           | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    MG/KG                                  | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrometra                           |       2  3              2  2                                             |      6  2.3|
      Cervix, Angiectasis                  |                                                                          |      1  2.0|
      Cervix, Cyst                         |                                                                          |      1  2.0|
      Endometrium, Cyst                    |                                           1                              |      3  1.7|
      Endometrium, Hyperplasia, Cystic     |                                                 2                 2      |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                                                       2           2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                       2                 2|      4  2.0|
      Inflammation, Granulomatous          |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                                                       X                  |      1     |
      Angiectasis                          |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                3         |      3  2.3|
      Necrosis                             |             1                                                            |      1  1.0|
      Lymphoid Follicle, Depletion Cellular|                                                 2                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Atrophy                              |                                                 2  4                 2   |      6  3.0|
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |             2     1  1     2           2     2        2     1           2|     17  1.4|
      Galactocele                          |                      2                                         1         |      2  1.5|
      Hyperplasia, Focal                   |                      2                                                   |      1  2.0|
      Lobular, Hyperplasia                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                2         |      1  2.0|
      Parakeratosis                        |                                                                2         |      1  2.0|
      Ulcer                                |                                                                2         |      1  2.0|
      Epidermis, Cyst                      |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  32                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7|            |
                             DAY ON TEST   | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2|            |
                                           | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    MG/KG                                  | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                                    |   2        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                1        1                             1  1     1         |     17  1.4|
      Mineralization                       | 1  1  1  1  1  1     1  1  1  1  1        1  1     1  1  1  1     1     1|     33  1.0|
      Alveolar Epithelium, Hyperplasia     |                   1     2                 2                    2         |      9  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  3.0|
      Developmental Malformation           |                            X                                             |      1     |
      Inflammation, Chronic Active         |          1                                                               |      1  1.0|
      Mineralization                       | 1  1     1  1  1  1  1  1     2  1     1  1     1  1  1  1  1  1  1     1|     36  1.0|
      Nephropathy                          | 2     1  2  2  2  2  2  2  2     2  2  2  1  3  1  1  2  2  1     2     1|     41  1.7|
      Pigmentation, Hemosiderin            |                                                    1           1         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |    3                                                                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  33                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|             
                                           | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|             
                                           | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Mineralization                       |                                  1                                       |             
      Parasite Metazoan                    |                         X                          X                 X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  A  +  +  M  +  A  +  +  A  A  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|             
      Mineralization                       |                                  1                             2         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      1   |             
      Basophilic Focus                     |          X  X  X        X  X     X  X  X           X           X     X  X|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |             X                          X           X                     |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                             X        X        X     X   |             
      Inflammation, Chronic Active         |                1  1           1                                1         |             
      Mixed Cell Focus                     |                         X              X                                 |             
      Necrosis                             |                                           1           1                  |             
      Bile Duct, Hyperplasia               |    1  2  2  1  1  1  1  2  2     1  3  1  1        2        3  1     1  2|             
      Centrilobular, Congestion            |                                                                          |             
      Centrilobular, Necrosis              |                                                 3                        |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      | 1  3                                      1     2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +     +     +     +  +  +        +              +|             
      Fat, Inflammation, Chronic Active    |             2                 2           2  3           3              3|             
      Fat, Mineralization                  |                                              2           2               |             
      Fat, Necrosis                        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +              +                                                  +   |             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |    1           3                       2           1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               2                                   2      |             
      Hyperkeratosis                       |                                                                   2      |             
      Inflammation, Chronic Active         |                               2        2                             2   |             
      Mineralization                       |                                                                1         |             
      Ulcer                                |                               2        2                          2  2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|             
                                           | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|             
                                           | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Mineralization                       |                                  4              1           2  4         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  4                             4         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  4                             4         |             
      Myocardium, Degeneration, Chronic    | 1  1  3  2  1  2  2     3  2  1  3  1  1  1  2  3  2  1  3     3     2  2|             
      Pericardium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            | 3  2                 1  1  1  1                       2        2  1     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                 3  3     3                          2   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |    3                       2     3     2           2        3  4     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                1                          1                              |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                       3        2         |             
      Necrosis                             |                                  3                                       |             
      Pars Distalis, Fibrosis              |                                                                          |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                   1      |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|             
                                           | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|             
                                           | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |       3                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2  1  2  2  1  2  1  1  1  1  2  1  1  1     2  1  1  1  1     3  1  1  1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    2  1        3  1  2   |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                  3                                       |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration                         | 2  1                                                           2     2   |             
      Mineralization                       | 2     2  2        1  1                 2              1  1  2  1     2   |             
      Necrosis                             |                                                                          |             
      Interstitial Cell, Hyperplasia       |    1                 1        1              1                    1  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +|             
      Myelofibrosis                        |                                        2                                 |             
      Necrosis                             | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                      +                        |             
      Ectasia                              |          2                                                               |             
      Pigmentation, Hemosiderin            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                     4                                    |             
      Ectasia                              |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          2                 2           2        1  1                 2   |             
      Hematopoietic Cell Proliferation     | 3                                                                    2   |             
      Necrosis                             |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                               1                                   2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Dilatation                           |    1     1  1     1  2  2  2  2  1  1  1     2           1  2  2  2      |             
      Galactocele                          |                         2                                                |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|             
                                           | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|             
                                           | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                2         |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |                                                                          |             
      Epidermis, Cyst                      |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                  2                             3         |             
      Osteosclerosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                             +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                   M                 +                          +        +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                   +                 +                          +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 3                                                                        |             
      Inflammation, Chronic Active         | 2  1        1                    2  2  2           2                     |             
      Mineralization                       |    1        1  1  1              2  1           1        1     2  1  1  1|             
      Necrosis                             | 3                                                                        |             
      Vacuolization Cytoplasmic            |    1                    1                                            1   |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
      Interstitium, Fibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                            2                          2           1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    1                     |             
      Mineralization                       |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                  3              1                    2   |             
      Nephropathy                          | 1  3     1     2  1  1  2  2  1  4  1  3  2  2     2     2  2  4  2  4  1|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|             
                                           | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|             
                                           | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                 2                        |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          | 3                                                                        |             
      Renal Tubule, Hyperplasia            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                     2                                    |             
      Mineralization                       |                                                                          |             
      Muscularis, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|             
                                           | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Granulomatous          |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                      X        X  X     X  X     X     X  X  X  X  X      |             
      Clear Cell Focus                     |                               X                                X         |             
      Eosinophilic Focus                   |                                  X                    X  X               |             
      Hemorrhage                           |                                                                2         |             
      Hepatodiaphragmatic Nodule           |                      X                                                  X|             
      Inflammation, Chronic Active         |                            2  1                    1        1  1         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                              1                           |             
      Bile Duct, Hyperplasia               |    1     1        2        2  1  1        1     2              1  1      |             
      Centrilobular, Congestion            |             3                                                            |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |       4  1  2                             1              2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +     +     +                 +                                 |             
      Fat, Inflammation, Chronic Active    |          2     3     3                 1                                 |             
      Fat, Mineralization                  |       2        1     2                                                   |             
      Fat, Necrosis                        |       4                                                                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1           1                     |             
      Acinus, Atrophy                      |    2  1     1     2                                         1     1     1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |       3                             3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|             
                                           | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |             1                                                            |             
      Mineralization                       |    1                                                                 1   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      1   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      1   |             
      Myocardium, Degeneration, Chronic    |    1  2  1  1  2     2     1  2  3  1  2  2  2  2  2  2  1  2  1  2  2   |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |       1  1  2  1  1  1     1        1  1  2        1                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  3                             3     3  1  2  3     3            |             
      Necrosis                             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |                      1                                               3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                         1                                2               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    3                                                                     |             
      Pars Distalis, Fibrosis              |                                                                3         |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                   1      |             
      C-Cell, Hyperplasia                  |       1                                                                  |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Granulomatous          |                                                             2            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|             
                                           | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                          3              4|             
      Hyperplasia                          |                                                          3               |             
      Inflammation, Chronic Active         | 2  1  1  1  1  1        1  1  1     1  1  2  2  1  1  1  2  3  1  1  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1        2     2                 1                 3   |             
      Inflammation, Granulomatous          |                                                             3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
      Inflammation, Granulomatous          |                                                             2            |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             2            |             
      Degeneration                         | 2     3  2  2                             2                              |             
      Mineralization                       | 2        2                                   2  2     2  2               |             
      Necrosis                             |                                        4                                 |             
      Interstitial Cell, Hyperplasia       |          3  2  1     2  3           2     4        1                 2  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Myelofibrosis                        |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                                            |             
      Ectasia                              |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                        2        2        2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          3               |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Necrosis                             |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Atrophy                              |                   2                 3     2                          3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |    2  3        2  2  1     1     2  1  2  2        1  1        1  1  2   |             
      Galactocele                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|             
                                           | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                      1   |             
      Pigmentation, Hemosiderin            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |                                              4                           |             
      Epidermis, Cyst                      |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteosclerosis                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             | 2                                                  2                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                  2        4  3                    1     2|             
      Mineralization                       |          1              1                 1           1        1  1      |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                      1                                         1  1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Fibrosis               |                                     1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 2  3                     |             
      Inflammation, Suppurative            |                                              3                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Retina, Degeneration                 |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   2      |             
      Degeneration                         |                2                                                         |             
      Mineralization                       |                                              1     1                 2   |             
      Nephropathy                          | 2     2  1     1  2  2     1  3  2  1  2  4  1  2  2  4  2  3  1  1  2   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|             
                                           | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Hemosiderin            | 3        1                                               1               |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                             3            |             
      Renal Tubule, Hyperplasia            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                      1   |             
      Muscularis, Inflammation, Suppurative|                                                                      3   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 0|                                                                       |      A     |
    0 MG/KG                                | 8|                                                                       |      L     |
                                           | 8|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  48        |
      Mineralization                       |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  43        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  48        |
      Mineralization                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |     23     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      6     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Inflammation, Chronic Active         |                                                                          |      9  1.1|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                                                                          |      3  1.0|
      Bile Duct, Hyperplasia               | 1                                                                        |     29  1.4|
      Centrilobular, Congestion            |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      9  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  14        |
      Fat, Inflammation, Chronic Active    |                                                                          |     10  2.4|
      Fat, Mineralization                  |                                                                          |      5  1.8|
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   3        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  49        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Acinus, Atrophy                      |                                                                          |     11  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Edema                                |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  44                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 0|                                                                       |      A     |
    0 MG/KG                                | 8|                                                                       |      L     |
                                           | 8|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Erosion                              | 2                                                                        |      2  1.5|
      Mineralization                       |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
      Mineralization                       |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Mineralization                       |                                                                          |      3  3.0|
      Myocardium, Degeneration, Chronic    |                                                                          |     43  1.8|
      Pericardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Vacuolization Cytoplasmic            | 2                                                                        |     22  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          | 3                                                                        |     15  2.7|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  46        |
      Hyperplasia                          |                                                                          |     10  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Cyst                                 |                                                                          |      2  1.0|
      Hyperplasia                          |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      2  3.0|
      Pars Distalis, Fibrosis              |                                                                          |      1  3.0|
      Pars Nervosa, Developmental          |                                                                          |            |
          Malformation                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  45                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 0|                                                                       |      A     |
    0 MG/KG                                | 8|                                                                       |      L     |
                                           | 8|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  51        |
      Degeneration                         |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |  51        |
      Cyst                                 |                                                                          |      3  3.3|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |     45  1.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |     10  1.8|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      9  2.0|
      Mineralization                       |                                                                          |     17  1.7|
      Necrosis                             |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |     16  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  48        |
      Myelofibrosis                        |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   4        |
      Ectasia                              |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Ectasia                              | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  46                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 0|                                                                       |      A     |
    0 MG/KG                                | 8|                                                                       |      L     |
                                           | 8|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Fibrosis                             |                                                                          |      7  1.9|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Necrosis                             | 3                                                                        |      1  3.0|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  42        |
      Atrophy                              |                                                                          |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |     31  1.5|
      Galactocele                          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Parakeratosis                        |                                                                          |      1  4.0|
      Epidermis, Cyst                      |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.5|
      Osteosclerosis                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |     12  2.0|
      Mineralization                       | 1                                                                        |     19  1.1|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  47                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 0|                                                                       |      A     |
    0 MG/KG                                | 8|                                                                       |      L     |
                                           | 8|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                                          |      6  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Interstitium, Fibrosis               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  50        |
      Inflammation, Chronic Active         | 3                                                                        |      3  2.7|
      Inflammation, Suppurative            |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      6  1.7|
      Nephropathy                          | 2                                                                        |     43  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      4  1.8|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  3.0|
      Renal Tubule, Hyperplasia            | 3                                                                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Muscularis, Inflammation, Suppurative|                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  48                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|             
                                           | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 MG/KG                                | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                                            1                        |             
      Basophilic Focus                     |    X     X  X        X  X           X  X  X  X     X  X  X     X  X  X  X|             
      Clear Cell Focus                     |                                                                X         |             
      Degeneration, Cystic                 | 3        1                    3                                          |             
      Eosinophilic Focus                   |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |                         1           1     1                              |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 1     1  1        1     1  1  1     1  1  1     1  1  1  1     1  2  1   |             
      Centrilobular, Necrosis              |       2                                                                  |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |             1        1        3                                      1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +              +        +            |             
      Fat, Inflammation, Chronic Active    |                                     3              2                     |             
      Fat, Mineralization                  |                                     3                                    |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2           1     2                          1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1                                                                  |             
      Inflammation, Chronic Active         |       1                                                                  |             
      Mineralization                       | 1                                3                                       |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Mineralization                       | 4  3     3                                3                              |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|             
                                           | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 MG/KG                                | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 4        3                                3                              |             
      Thrombosis                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2        3                                3                              |             
      Thrombosis                           |                               3                                          |             
      Myocardium, Degeneration, Chronic    | 3  2  2  1  2        1     2  2     2  2  3  2  2  2  1     1  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                    2                                          |             
      Vacuolization Cytoplasmic            | 2              1                 1     2  2  1  2     3           1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            4        3  2  3  3  2        3        2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          | 3  3     3                                3                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   2      |             
      Hyperplasia                          | 1  1                                                                     |             
      Mineralization                       |                                           1                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1                                                               |             
      Ultimobranchial Cyst                 |                1  1  2  2                                                |             
      Follicle, Cyst                       |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                2  1                                                      |             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             2            |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Chronic Active         | 2     1  1        1        1  1  1  1     1  1  2  1  1  2     1  1  1   |             
      Mineralization                       | 1                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|             
                                           | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 MG/KG                                | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    2                          3           3                       3      |             
      Mineralization                       | 2        2        1                                         1  1         |             
      Interstitial Cell, Hyperplasia       |       1     2  2  4     1                    2  2  3  2           3  2  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
      Ectasia                              |                                                          2               |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                         3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                               3  3                                       |             
      Fibrosis                             |                               3        1                                2|             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Pigmentation, Hemosiderin            |                                                 3                        |             
      Lymphoid Follicle, Depletion Cellular|             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Atrophy                              |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             1  1              2  1           1           1     2  2     2|             
      Galactocele                          |                                                                3         |             
      Hyperplasia                          |                                                 3                        |             
      Mineralization                       | 2  1     2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |       4                                                                  |             
      Ulcer                                |       4                                                                  |             
      Epidermis, Cyst                      |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 4  2     4                                4     2                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|             
                                           | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 MG/KG                                | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                      +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                 3                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                1     1                    2  2  3                    1  1|             
      Mineralization                       | 2  1  1  1              1     1  1     1  1                    1     1  1|             
      Proteinosis                          |                                                                          |             
      Vacuolization Cytoplasmic            |    1                                   1     2              2  1  2      |             
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |             
      Interstitium, Fibrosis               |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3  2                                                     3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Degeneration                         |                                                                          |             
      Lens, Mineralization                 |                                              3                           |             
      Retina, Degeneration                 |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3     4                                   2           2               |             
      Hyperplasia, Oncocytic               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 2     2                                   2                              |             
      Nephropathy                          | 4  4  2  4  2  2  2  1  1     2  2  3  3  4  3  3  1  3  3  2  3  3  1  3|             
      Pigmentation, Hemosiderin            |                               3                                   3      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2|            |
                                           | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    3 MG/KG                                | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
      Mineralization                       |                            1              1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                      X                             X                 X   |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  A  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
      Mineralization                       |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |          X     X     X  X  X        X     X     X  X  X  X     X        X|     29     |
      Clear Cell Focus                     |                                                                X         |      2     |
      Degeneration, Cystic                 |                                           2                              |      4  2.3|
      Eosinophilic Focus                   | X                                                           X        X   |      4     |
      Hematopoietic Cell Proliferation     |                                                                1         |      2  1.5|
      Hepatodiaphragmatic Nodule           | X                    X                                X                  |      3     |
      Inflammation, Chronic Active         |                1                                                         |      4  1.0|
      Mixed Cell Focus                     |                                                                         X|      1     |
      Necrosis                             |                               1                                          |      1  1.0|
      Bile Duct, Hyperplasia               |       1  1  2     1     1           1           1        2        1  2   |     27  1.1|
      Centrilobular, Necrosis              |                   2              3                                       |      3  2.3|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                  2  2                                    |      6  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                               +        +               |   6        |
      Fat, Inflammation, Chronic Active    | 3                                               2                        |      4  2.5|
      Fat, Mineralization                  |                                                          2               |      2  2.5|
      Fat, Necrosis                        | 3                                                        2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy                      |                   1  2              1                                    |      7  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                               3                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 4                             2                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  53                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2|            |
                                           | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    3 MG/KG                                | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      2  2.0|
      Ulcer                                | 4                                               1                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                            3              3                              |      6  3.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                            3              4                              |      5  3.4|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                            3              4                              |      5  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Myocardium, Degeneration, Chronic    | 1     2  2  2  2  1  2  2  3  1  2  2  1  3     2  2  1  2  1  2  2  1  2|     43  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            | 1              1  1     1     4  1  1     1  2  1        2        2      |     23  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1     1     1        4  4     3  1     1           3         |     17  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|  44        |
      Hyperplasia                          | 2              2     2     3     2        3        2  3  2              3|     14  2.6|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                           3                              |      2  2.5|
      Hyperplasia                          |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                2              1                                          |      6  1.5|
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  54                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2|            |
                                           | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    3 MG/KG                                | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Degeneration                         |                                              3                           |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                              1                           |      2  1.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1     1  2  1  2  1  2  1  1  2        1  2     1  1  2  1  2  1  1  1   |     37  1.3|
      Mineralization                       |                                           1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                              2                           |      1  2.0|
      Inflammation, Chronic Active         |                      2     2              1                 2            |      5  1.8|
      Mineralization                       |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                           2        2     2  2        3   |      9  2.4|
      Mineralization                       |                      1     1              1           1              2   |     10  1.3|
      Interstitial Cell, Hyperplasia       | 1     1  2  2                             4     2        2  1  2  1      |     22  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |             1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +              +                    +      |   4        |
      Ectasia                              |                                                                   2      |      2  2.0|
      Hemorrhage                           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia                              |                                                    2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                           2                              |      1  2.0|
      Ectasia                              |                                                             2  2  2     2|      5  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                          2               |      1  2.0|
      Congestion                           |                                                                          |      2  3.0|
      Fibrosis                             |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |                   2                                         2            |      3  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  42        |
      Atrophy                              |          2                                3                              |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  55                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2|            |
                                           | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    3 MG/KG                                | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           | 2        2  2     2  2  1  1  1     1     2     1     2     1     2     1|     24  1.5|
      Galactocele                          | 2                    2                                            2      |      4  2.3|
      Hyperplasia                          |                                                                          |      1  3.0|
      Mineralization                       |                                           1                              |      4  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parakeratosis                        |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
      Epidermis, Cyst                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                            3              4                             2|      8  3.1|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |          1           2              1  2           1  2                  |     13  1.5|
      Mineralization                       | 1                    2  1  1  1     1  1  3              1  1  1  1  1   |     25  1.2|
      Proteinosis                          |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic            |                                                 1                        |      7  1.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Interstitium, Fibrosis               |                            1                                             |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                  2                 2                    2|      6  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   2        |
      Degeneration                         |                                                       4                  |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  56                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2|            |
                                           | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    3 MG/KG                                | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|      L     |
                                           | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lens, Mineralization                 |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        2              2                 2|      7  2.4|
      Hyperplasia, Oncocytic               |                   4                                                      |      1  4.0|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
      Mineralization                       |                   1        1              3                              |      6  1.8|
      Nephropathy                          | 3     2  2  2  4  2  4  3  4  3  2  1     4  1  3  3  3  2  1  2  3  2  4|     47  2.6|
      Pigmentation, Hemosiderin            |          2  1                                                            |      4  2.3|
      Renal Tubule, Hyperplasia            |                                           4                             4|      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2                           |      1  2.0|
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  57                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|             
                                           | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                            X                 X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X  X     X  X     X  X     X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                   X                          X  X     X                  |             
      Eosinophilic Focus                   |                                                       X                  |             
      Fatty Change                         |                                        2                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                             X                     |             
      Inflammation, Chronic Active         |                                                       1                  |             
      Mixed Cell Focus                     |          X                                               X               |             
      Necrosis                             |                                           2                              |             
      Bile Duct, Hyperplasia               | 1  1     1  2     1  1     1     1                    1                  |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |                                  3                                       |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                               1        2                    2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1                       1           1           1  1  1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         | 3              2                       2           2     3  1  2         |             
      Mineralization                       |                                                 4                    2   |             
      Perforation                          |                                                          X     2         |             
      Ulcer                                | 4              4                          2                              |             
      Epithelium, Hyperplasia              |       3                                                        2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  2                                       |             
      Mineralization                       |          2                          3           3                 3  3   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|             
                                           | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                     3           4                 2  4   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          3                 2        2           4                 2  4   |             
      Myocardium, Degeneration, Chronic    | 2  2  2  3  1  2  1  2  3  1  1  3  3  2  2  2  3  2  2  2  1  1  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Vacuolization Cytoplasmic            | 3  1  2     1  3  1  3        1  3  2     2     2     1  3  3  2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3           1     1           4  3     4     3     1  1     2     3   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2  3                 3        3           3  1     1        3  3  1|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |    1           1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1  1  2  1  1     1     3  1  1  2  1     2  3  2        2  1  2  2  1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         | 2  3  3  2  2  3           3  1           2  3  3  1  2  2  3  2  2  2  3|             
      Mineralization                       | 1  2  2  1  1  1  1  1              1  2     2  2  1  1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2  2                                                   |             
      Inflammation, Chronic Active         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  59                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|             
                                           | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Ectasia                              |       2                                                                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              3                           |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Thrombosis                           |                                           3                              |             
      Lymphoid Follicle, Depletion Cellular|                            3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  M  +  +  M  +  +  +  +|             
      Atrophy                              |             3        4     4                                      3     4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Dilatation                           |       2        1     2  3     1                    3  2  1  3  1        2|             
      Galactocele                          |                                                                          |             
      Hyperplasia, Focal                   |       1                                                                  |             
      Mineralization                       |                                     2                                2   |             
      Lobular, Hyperplasia                 |          1  1  1                    1                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 3        3     3           3        1        2  4        1        3  2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
      Demyelination                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               4                                          |             
      Inflammation, Chronic Active         |          2           2                       2  2           1            |             
      Mineralization                       |       1     1     1  1     1     1  2           3  1        1     1  2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |          1              1              1              1  1               |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   3                                                      |             
      Inflammation, Suppurative            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  60                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|             
                                           | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                       +                        |             
      Cornea, Inflammation, Suppurative    |                                                 2                        |             
      Cornea, Mineralization               |                                                 1                        |             
      Cornea, Necrosis                     |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                             2                                   2|             
      Mineralization                       |          1                          3     2     3                 2  3   |             
      Nephropathy                          | 4  1  3  4  2  4  2  2  4  4  2  1  4  3  3  4  4  3  2  3  3  4  4  4  3|             
      Pigmentation, Hemosiderin            |                      1                                                   |             
      Renal Tubule, Hyperplasia            |                                                    3  1     1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  61                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3|            |
                             DAY ON TEST   | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5|            |
                                           | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    30 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X        X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X      |     41     |
      Clear Cell Focus                     |                                                       X     X            |      6     |
      Eosinophilic Focus                   |                      X                             X     X               |      4     |
      Fatty Change                         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                      1  1|      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Chronic Active         |                      1                 1                                 |      3  1.0|
      Mixed Cell Focus                     |                                           X           X                  |      4     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    1  1  1           1  3           1  1  1     2  1  1  1  1  1  1      |     24  1.2|
      Centrilobular, Degeneration          |                   2                                                      |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      | 1  1              2                 1        2     1     2               |     10  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +     +                                +  +                     |   5        |
      Fat, Inflammation, Chronic Active    |       2  2     2                                2  2                     |      5  2.0|
      Fat, Mineralization                  |       3  2     2                                                         |      3  2.3|
      Fat, Necrosis                        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |          2     2        2                    1              1            |     11  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                1         |      1  1.0|
      Inflammation, Chronic Active         |    1                          3                                          |      9  2.1|
      Mineralization                       |                                                                          |      2  3.0|
      Perforation                          |                                                                          |      2  2.0|
      Ulcer                                |                               3                                          |      4  3.3|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  62                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3|            |
                             DAY ON TEST   | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5|            |
                                           | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    30 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |             3     4                                                      |      7  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |             +                                                            |   1        |
      Vacuolization Cytoplasmic            |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             3     3                                                      |      6  3.2|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             3     4                                                      |      8  3.0|
      Myocardium, Degeneration, Chronic    | 1  2  2  1  3  1  3  3  2     1  2  1  1  1  2  1  2  2  2  2  1  1  1   |     48  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                         3|      1  3.0|
      Vacuolization Cytoplasmic            | 3  3  2  2  1  1  2  1  2  2  3  1  1  1     2  1  1  1     2     1     3|     40  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1  2     3           1     3           3                 3           4|     20  2.5|
      Inflammation, Chronic Active         |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin            |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 2           3     3           2                    2        1            |     17  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                1                                2                        |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                              2                           |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |                            2                                             |      1  2.0|
      Degeneration                         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1  1  1     3  1  2  1  2  1  1     1  1  1  1  1  1  2  1  1  1  1     1|     42  1.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  63                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3|            |
                             DAY ON TEST   | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5|            |
                                           | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    30 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         | 1  2     2  3     3  1        2  2  2     1  1  2  2  2  2  2     1     1|     37  2.1|
      Mineralization                       | 1  2           1  2  1  1  1  2  2  2     1  1  1  1     1  1            |     33  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                            2                                             |      1  2.0|
      Ectasia                              | 3                                                     2                  |      3  2.3|
      Necrosis                             |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                           2                              |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                         3|      2  2.5|
      Thrombosis                           |                                                                          |      1  3.0|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  +  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +|  38        |
      Atrophy                              |             4                          3                                 |      7  3.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           | 1  1  1           2        2  3           2  2     1  1  1           1   |     23  1.7|
      Galactocele                          |                                           3                              |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Mineralization                       |                   1                                                      |      3  1.7|
      Lobular, Hyperplasia                 |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1           2     2                                                      |     13  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                 2                        |      2  2.5|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  64                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3|            |
                             DAY ON TEST   | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5|            |
                                           | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    30 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                        +           +                 +   |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                        +           +                 +   |   4        |
      Demyelination                        |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                      1           3           3              1     1     1|     11  1.7|
      Mineralization                       | 1  1  1  1  1     3        1        1     1     1  1  1     1  1        1|     27  1.2|
      Necrosis                             |                                              3                           |      1  3.0|
      Vacuolization Cytoplasmic            |    1                             1                                       |      7  1.0|
      Alveolar Epithelium, Hyperplasia     |    1                 2                                                   |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                   3      |      2  3.0|
      Inflammation, Suppurative            |                               1  2                                       |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Cornea, Mineralization               |                                                                          |      1  1.0|
      Cornea, Necrosis                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  2                                       |      4  2.0|
      Mineralization                       |             2     3        1                                             |      9  2.2|
      Nephropathy                          | 4  3  1  3  4  2  4  2  2  1  3  4  2  1  3  2  3  2  2  1  3  1  2  1  1|     50  2.7|
      Pigmentation, Hemosiderin            |                         2                                                |      2  1.5|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  65                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|             
                                           | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    150                                    | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Periesophageal Tissue, Hemorrhage    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                               X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  M  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Basophilic Focus                     | X           X  X  X  X  X  X  X  X  X  X     X  X  X  X           X  X  X|             
      Clear Cell Focus                     |                   X     X     X                 X                       X|             
      Eosinophilic Focus                   |                                                 X                        |             
      Hepatodiaphragmatic Nodule           |          X        X                          X                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |             X                                                        X   |             
      Necrosis                             |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Centrilobular, Congestion            |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                   1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Fat, Inflammation, Chronic Active    |                                                             2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                       2              2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                      2     4                 2                           |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                      2     3     2           2                           |             
      Epithelium, Hyperplasia              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Mineralization                       | 3                                                              3         |             
      Ulcer                                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Mineralization                       | 4                                                              2         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Mineralization                       | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  66                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|             
                                           | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    150                                    | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                      3   |             
      Myocardium, Degeneration, Chronic    | 3  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  3  2           3  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Vacuolization Cytoplasmic            | 3  1  1  1     3     3  1  3  1  3  1  1     2              2  2     1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          | 3  2              3  3  3     4              3                           |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
      Hyperplasia                          | 2           3        2     2     2           2                 2  3  2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |             1                                                            |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                            2                                             |             
      Pars Distalis, Hyperplasia           |                                                    1                     |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2        1  1        1  1  1     1     1     1  1  1  1     1  2  2  1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Degeneration                         | 1  2  1  1     2     1  2        2     1           1  1     1  1  1  1  1|             
      Mineralization                       | 1        2     1  1  1  1              1           1        1        1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  67                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|             
                                           | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    150                                    | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       2                                                                  |             
      Ectasia                              |                                                    3  2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   2  2   |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  +  M|             
      Atrophy                              | 3  3  2  2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  2              1  1        1  2  2  2  1              2  1     1  1   |             
      Galactocele                          |          3                       2     2              2                  |             
      Hyperplasia, Focal                   |                                        2                                 |             
      Mineralization                       |                                                                3         |             
      Lobular, Hyperplasia                 | 1           1  1  3  1  1  1     1  1        1     2  1     2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parakeratosis                        |                                                                          |             
      Hair Follicle, Cyst                  |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 3           2        2     2                       2           3  1  1   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Congestion                           |                                           2                              |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                     1     1  3  1                 1  2   |             
      Mineralization                       | 3              1  1  1  1        1  1  1     1  1                 1  1  1|             
      Vacuolization Cytoplasmic            |                   1                    1     2                           |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                2           1                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  68                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|             
                                           | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    150                                    | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens, Mineralization                 |                         2                                                |             
      Retina, Degeneration                 |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |             2              2           2                                 |             
      Mineralization                       | 3           1              1  2     1     1  1              1           1|             
      Nephropathy                          | 4  1  2  2  3  4  2  3  2  3  2  3  2  3  1  3  1  4  3     2  4  4  3  2|             
      Pigmentation, Hemosiderin            |    2  2              1                                      2            |             
      Renal Tubule, Hyperplasia            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                                      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  69                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|             
                                           | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Hemorrhage    |                                        1                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  A  +  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X     X  X  X  X  X     X           X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                X  X  X                          X                    X  X|             
      Eosinophilic Focus                   |                                                                      X   |             
      Hepatodiaphragmatic Nodule           |                                              X  X     X                  |             
      Inflammation, Chronic Active         |                                                                         1|             
      Mixed Cell Focus                     |    X                                                                 X   |             
      Necrosis                             |    2                                                                     |             
      Bile Duct, Fibrosis                  |                                              1                           |             
      Centrilobular, Congestion            |                                                          2               |             
      Centrilobular, Necrosis              |                                                    3                     |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +                                                |             
      Fat, Inflammation, Chronic Active    |    2                    2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       2                                                           2      |             
      Inflammation, Chronic Active         |          2                                                               |             
      Mineralization                       |                                  1                 3                     |             
      Ulcer                                |                                                       3                  |             
      Epithelium, Hyperplasia              |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  3           3     4        3     3      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  3           3     3        3     2      |             
                                            __________________________________________________________________________|             
   Heart                                   | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  4           2     4        3            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  70                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|             
                                           | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |             2                                                            |             
      Myocardium, Degeneration, Chronic    |       3  1  1  2  2  2  2     1  3           3  1  3  2  2  3  1  3  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |       2  3           1     1     1        2  2     2  2  1  3  1  2  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3        1              1                 3  2     2        3  3|             
      Mineralization                       |                                                    1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  M  +  +     M  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                       3           3     3        3     3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                1  2                                                      |             
      Hyperplasia                          |                                                             1            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2  1  1     2  1  1  1  1     2     1  1  2  1  2        2  1  3  1  1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                              2     2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                   3      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                2  2  1  1        2           2  1           1  1  2  1  1|             
      Mineralization                       |    1     1     1     1                          2  2           1  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  71                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|             
                                           | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                              1                 2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |    X                                                                     |             
      Hematopoietic Cell Proliferation     |                                              3                           |             
      Lymphoid Follicle, Depletion Cellular|             2                 2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  +  +  M  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                          3           2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             2                 2  2     1  1  2  1  1  3     2            |             
      Galactocele                          |                         3                    3        2                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Mineralization                       |                                                    2                     |             
      Lobular, Hyperplasia                 |    2  2  1  1        1        1  1        1  1  2  2  1  1  2  3  2  1  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 1                        |             
      Parakeratosis                        |                                                 3                        |             
      Hair Follicle, Cyst                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       2  1                       2           3     3        2     3      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                           3                              |             
      Hemorrhage                           |                                                                   3      |             
      Inflammation, Chronic Active         |       1                       2  1        3     1  2                 1  1|             
      Mineralization                       |          1  1  1  1  1     1     1           3  1  1  1     2  1        1|             
      Vacuolization Cytoplasmic            |       1                                                                  |             
      Alveolar Epithelium, Hyperplasia     |                         2                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          3               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                   +                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  72                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|             
                                           | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens, Mineralization                 |                                                 2                        |             
      Retina, Degeneration                 |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          1           3                                   3               |             
      Mineralization                       | 1              2  1        1  1  3     1  1  3  1  3        3  1     2  1|             
      Nephropathy                          |    2  4  4  1  3  2  2  3  1  1  4     1  1  4  3  4  3  3  4  3  4  2  3|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                                            |             
      Transitional Epithelium, Hyperplasia |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  73                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    150                                    | 6|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  49        |
      Periesophageal Tissue, Hemorrhage    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  47        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  46        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  49        |
      Basophilic Focus                     | X                                                                        |     38     |
      Clear Cell Focus                     | X                                                                        |     12     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      4     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Centrilobular, Congestion            |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Inflammation, Chronic Active    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  48        |
      Acinus, Atrophy                      | 1                                                                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  48        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  2.5|
      Mineralization                       |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      5  2.4|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  48        |
      Mineralization                       |                                                                          |      7  3.1|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  74                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    150                                    | 6|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  48        |
      Mineralization                       |                                                                          |      7  2.9|
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  47        |
      Mineralization                       |                                                                          |      5  3.4|
      Thrombosis                           |                                                                          |      2  2.5|
      Myocardium, Degeneration, Chronic    | 2                                                                        |     42  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  49        |
      Vacuolization Cytoplasmic            | 2                                                                        |     33  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  49        |
      Hyperplasia                          |                                                                          |     15  2.6|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  43        |
      Hyperplasia                          |                                                                          |     15  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  49        |
      Angiectasis                          | 4                                                                        |      1  4.0|
      Cyst                                 |                                                                          |      3  1.3|
      Hyperplasia                          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
      Pars Nervosa, Developmental          |                                                                          |            |
          Malformation                     | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |  49        |
      Inflammation, Chronic Active         | 2                                                                        |     36  1.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  49        |
      Mineralization                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  48        |
      Mineralization                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  75                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    150                                    | 6|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  49        |
      Degeneration                         |                                                                          |     28  1.3|
      Mineralization                       | 1                                                                        |     19  1.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              | 2                                                                        |      5  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  48        |
      Accessory Spleen                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  39        |
      Atrophy                              |                                                                          |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  50        |
      Dilatation                           |                                                                          |     23  1.6|
      Galactocele                          |                                                                          |      7  2.4|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.5|
      Lobular, Hyperplasia                 |                                                                          |     35  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Parakeratosis                        |                                                                          |      1  3.0|
      Hair Follicle, Cyst                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  50        |
      Fibrous Osteodystrophy               |                                                                          |     15  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  76                                                               
NTP Experiment-Test: 88032-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:29:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    150                                    | 6|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  47        |
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |     14  1.5|
      Mineralization                       | 1                                                                        |     28  1.2|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.3|
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Lens, Mineralization                 |                                                                          |      2  2.0|
      Retina, Degeneration                 |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  49        |
      Cyst                                 |                                                                          |      6  2.2|
      Mineralization                       | 1                                                                        |     25  1.5|
      Nephropathy                          | 3                                                                        |     48  2.7|
      Pigmentation, Hemosiderin            |                                                                          |      4  1.8|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  49        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  77                                                               
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