Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4417

TDMS Study 88034-03 Pathology Tables

NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  I  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |          X     X     X        X  X  X                 X  X     X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                      X              X                 X        X     X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X              X                 X        X         |             
      Pheochromocytoma Benign              |                                  X                                       |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                X              X     X                          X     X   |             
      Pars Distalis, Adenoma               | X  X     X  X           X              X     X  X  X     X  X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |    X                                                              X      |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +     +  +  +  +  +  +  +  +  +  +  M     +  +  M  +  +  +  +  M  +  +|             
      Adenoma                              |          X           X  X                       X                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Arrhenoblastoma Malignant            |                      X                                                   |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                         X        X     X                    X        X   |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal, Multiple            |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                X     X        X     X                 X        X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +              +                       +              +  +|             
      Iliac, Histiocytic Sarcoma           |                                                                         X|             
      Lumbar, Leukemia Mononuclear         |                X                                                         |             
      Pancreatic, Histiocytic Sarcoma      |                                                                         X|             
      Pancreatic, Leukemia Mononuclear     |                               X                       X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M     +  +  +  +  M  +  +  +  +  +  M     M  +  +  M  +  +  M  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |          X     X                    X                                X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                      X        X     X                 X        X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |    X                                                                     |             
      Leukemia Mononuclear                 |                X     X        X                       X        X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  M  +  +  +  M  +  +  +  +  +     M  +  +  M  +  M  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                X     X        X     X                                X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |          X     X     X        X  X  X                 X  X     X     X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  M  +  +  +  +  +  +     +  M  +  M  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |                                                    X                     |             
      Fibroadenoma                         |    X     X           X                       X        X           X  X   |             
      Fibroadenoma, Multiple               |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                          X               |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |          X     X     X        X     X                 X        X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X     X        X     X                 X        X     X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |          X     X     X        X  X  X                 X  X     X     X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  I     I  +  I  +  I  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X  X     X        X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +           +                          +               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
      Squamous Cell Papilloma              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Carcinoma                            |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X                 X  X              X                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                 X                 X                        |             
      Pheochromocytoma Benign              | X        X                             X              X                  |             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
      Pars Distalis, Adenoma               | X  X  X     X  X  X     X  X  X  X  X  X     X  X  X     X  X  X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                 X                        |             
      C-Cell, Adenoma                      |             X                                                  X         |             
      Follicular Cell, Carcinoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Arrhenoblastoma Malignant            |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                       X                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Polyp Stromal                        | X              X                       X                                 |             
      Polyp Stromal, Multiple              |                                     X                       X            |             
      Sarcoma Stromal, Multiple            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X                 X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +     +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +     M  M  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X  X     X        X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            | X                                      X                                 |             
      Fibroadenoma                         | X  X     X              X        X  X           X     X     X     X      |             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Squamous Cell Carcinoma              |                                                       X                  |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X  X              X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X     X           X                 X                        |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X     X           X  X     X        X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  I  +        +                                                         |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +        +                                                         |  50        |
      Carcinoma                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         10 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Pheochromocytoma Benign              |                                                                          |          5 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +                                                         |  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +                                                         |  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |          7 |
      Pars Distalis, Adenoma               | X  X                                                                     |         34 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +                                                         |  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          4 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +        +                                                         |  43        |
      Adenoma                              |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +                                                         |  50        |
      Arrhenoblastoma Malignant            |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +                                                         |  50        |
      Polyp Stromal                        |                                                                          |          8 |
      Polyp Stromal, Multiple              |                                                                          |          2 |
      Sarcoma Stromal, Multiple            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Iliac, Histiocytic Sarcoma           |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Pancreatic, Histiocytic Sarcoma      |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +        +                                                         |  43        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +                                                         |  48        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +                                                         |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M        +                                                         |  39        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +                                                         |  45        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            | X                                                                        |          4 |
      Fibroadenoma                         |    X                                                                     |         18 |
      Fibroadenoma, Multiple               | X                                                                        |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +                                                         |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         | X                                                                        |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         14 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |         13 |
      Renal Tubule, Adenoma                | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |         17 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                  X                                       |             
      Leukemia Mononuclear                 |                X     X        X  X     X  X  X     X                    X|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                          +        +              +                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                            +                                             |             
      Pharyngeal, Squamous Cell Papilloma  |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Complex             |                                     X                                    |             
      Pheochromocytoma Benign              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +     +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X        X                              |             
      Pars Distalis, Adenoma               |    X     X  X     X  X     X  X        X     X  X     X     X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X        X     X         |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |             X                                                     X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Granulosa-Theca Tumor Malignant      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |          X                       X           X                          X|             
      Polyp Stromal, Multiple              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X        X        X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +  +  +  M     +  M  M  M  +  M  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                   X                     |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                X                 X        X        X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X     X                    X        X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                X                 X        X        X                     |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X        X  X     X  X  X     X                    X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  M  +  +  +     +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         | X                                            X  X        X              X|             
      Fibroadenoma, Multiple               |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |             
      Leukemia Mononuclear                 |                X     X        X  X        X  X     X                    X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X        X                              |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  I     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X        X  X     X  X  X     X                    X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X  X|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X  X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X  X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                  X                                       |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                 X     X  X        X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X     X  X        X  X   |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                      X     X                             X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |             X                                                            |             
      Carcinoma                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                 X  X  X|             
      Pars Distalis, Adenoma               | X  X  X     X        X  X  X     X  X  X  X  X  X  X  X  X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                      X                                                   |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                         X                          X                     |             
      Carcinoma                            |                         X                                                |             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Granulosa Cell Tumor Malignant       | X                                                                        |             
      Granulosa-Theca Tumor Malignant      |                                              X                           |             
      Leukemia Mononuclear                 |                                                 X     X  X           X  X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
      Polyp Stromal                        |       X                                   X  X           X        X  X   |             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +        +              +                 +           +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
      Deep Cervical, Leukemia Mononuclear  |                                                                      X  X|             
      Pancreatic, Leukemia Mononuclear     |             X                                         X           X  X   |             
      Renal, Leukemia Mononuclear          |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +        +  +  +  +  M  +  M  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |             X                                   X     X           X  X  X|             
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +        +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  M     +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
      Leukemia Mononuclear                 |             X                                   X     X           X  X  X|             
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  M  +  +  +  +  +     M  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
      Leukemia Mononuclear                 |                                                 X     X  X           X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         | X  X  X                          X                 X     X               |             
      Fibroadenoma, Multiple               |                         X                 X  X              X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Keratoacanthoma                      |                                                    X                     |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Osteosarcoma                         |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X        X           X  X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |             X                                   X     X           X  X  X|             
      Renal Tubule, Adenoma                |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |             X                                   X     X  X        X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +  I                                                         |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +                                                         |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         18 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +                                                         |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  22                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X                                                               |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          6 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |             X                                                            |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |          X                                                               |          8 |
      Pars Distalis, Adenoma               | X     X     X                                                            |         36 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +                                                         |  50        |
      C-Cell, Adenoma                      | X           X                                                            |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +                                                         |  50        |
      Adenoma                              |                X                                                         |          3 |
      Carcinoma                            |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +                                                         |  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Granulosa-Theca Tumor Malignant      |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |       X                                                                  |         11 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   9        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          5 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     M  M  +  +                                                         |  39        |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +  +                                                         |  47        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +  +  +  +                                                         |  46        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |         11 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X  X                                                            |         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M  +  M  +                                                         |  43        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +                                                         |  49        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            | X                                                                        |          1 |
      Fibroadenoma                         |       X                                                                  |         12 |
      Fibroadenoma, Multiple               |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +                                                         |  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |       X                                                                  |          1 |
      Subcutaneous Tissue, Melanoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +                                                         |  50        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X                                                               |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +                                                         |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Adrenal Cortex| X                                                                        |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         17 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X  X                                                            |         10 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |          X                                                               |          4 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X  X                                                            |         18 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X  X     X  X              X     X  X           X  X  X              X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +        +           +  +                              |             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                   X                                                      |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                            X                    X                        |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 | X  X                                            X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                       X                  |             
      Leukemia Mononuclear                 |             X              X        X           X  X                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |             X              X        X           X  X                     |             
      Pheochromocytoma Benign              |                            X                                   X         |             
      Bilateral, Pheochromocytoma Benign   |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                     X           X  X                     |             
      Pars Distalis, Adenoma               | X        X     X  X     X  X  X  X  X     X  X  X     X  X  X  X     X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      C-Cell, Adenoma                      |                                  X  X                                   X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Carcinoma                    |                                                 X           X            |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  I     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                       X                  |             
      Carcinoma                            |                                           X                 X            |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Leukemia Mononuclear                 | X           X              X                    X  X                     |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Polyp Stromal                        |             X  X  X                                      X           X   |             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X           X              X        X           X  X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                          +                                             |             
      Iliac, Leukemia Mononuclear          |                            X                                             |             
      Pancreatic, Leukemia Mononuclear     | X                          X                                             |             
      Renal, Leukemia Mononuclear          |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +     +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +     +  M|             
      Leukemia Mononuclear                 |                            X     X  X           X  X  X                  |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M     +  +|             
      Leukemia Mononuclear                 | X  X     X  X              X        X           X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 | X           X              X        X           X  X  X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +     M  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X        X  X              X                    X  X  X                  |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 | X  X     X  X              X     X  X           X  X  X              X   |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +|             
      Leukemia Mononuclear                 |                                                 X  X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                    X                     |             
      Carcinoma                            |                               X                                          |             
      Fibroadenoma                         |                   X     X  X     X     X  X  X  X     X  X     X     X  X|             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                X         |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                     X              X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X  X     X  X              X     X  X           X  X  X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |             X                    X              X  X                     |             
      Glands, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X        X                 X                    X  X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |    X                       X                    X                        |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X  X     X  X              X     X  X           X  X  X              X   |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  I     +  I  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     I  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                               +  +     +           +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                      X                                X                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                  X                    X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                                X         |             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
      Pheochromocytoma Benign              |                                                                         X|             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  M  +  +  +  +  +  M  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                      X                                X        X         |             
      Pars Distalis, Adenoma               | X  X     X  X  X  X     X  X  X     X           X     X  X           X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      C-Cell, Adenoma                      | X                                                           X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                  X                                       |             
      Follicular Cell, Carcinoma           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +  +  +  +  +  M  +  +  +        +  +  +  +  +  +     +  +|             
      Adenoma                              |    X                                                  X  X              X|             
      Carcinoma                            |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Bilateral, Adenoma                   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +     +  +|             
      Granulosa Cell Tumor Malignant       |    X                                                                     |             
      Leukemia Mononuclear                 |                      X                                X        X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Polyp Stromal                        |                                                                          |             
      Polyp Stromal, Multiple              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     M  +  +  +  M  +  +  M  M  +  +        +  +  +  +  +  +     +  M|             
      Leukemia Mononuclear                 |                                                       X        X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  M        +  +  +  +  +  +     M  +|             
      Leukemia Mononuclear                 |                      X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                      X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     M  M  M  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X           X                    X        X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                  X                             X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                X                    X                                    |             
      Fibroadenoma                         |    X                    X  X  X     X           X                        |             
      Fibroadenoma, Multiple               |                X                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |    X                                                  X                  |             
      Glands, Adenoma                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X           X                    X        X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X                 X           X                    X        X         |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  11        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |         10 |
      Pheochromocytoma Benign              |          X  X                                                            |          5 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  46        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Pars Distalis, Adenoma               | X  X  X  X  X  X                                                         |         38 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +                                                         |  47        |
      Adenoma                              |          X     X                                                         |          7 |
      Carcinoma                            |                                                                          |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  49        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |    X        X                                                            |          7 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   3        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  M  +                                                         |  36        |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  46        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  35                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +  +                                                         |  41        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         11 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |         16 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          3 |
      Fibroadenoma                         | X  X        X                                                            |         22 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |    X        X                                                            |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         15 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  36                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Glands, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         16 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  37                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  I  +  +  +  I  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                               X                                          |             
      Leukemia Mononuclear                 |    X  X  X        X  X        X     X                             X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                    +                                   +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |    X                 X              X                                   X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Ganglioneuroma                       | X                                                                        |             
      Leukemia Mononuclear                 |    X                 X                                                   |             
      Pheochromocytoma Benign              |             X     X                             X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X              X                             X     X|             
      Pars Distalis, Adenoma               | X     X  X  X  X  X     X     X  X           X  X     X  X  X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                         X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |    X                                                                     |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  I  +  +  +  +  +  +  +        +  +     +  +  +  +  +  M  +|             
      Adenoma                              |          X        X  X           X           X        X                  |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Deciduoma Benign                     |                                                                          |             
      Polyp Stromal                        |                      X                                                   |             
      Polyp Stromal, Multiple              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X                    X     X                                   X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             
      Iliac, Leukemia Mononuclear          |                               X                                          |             
      Renal, Leukemia Mononuclear          |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  M  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X           X        X     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X           X        X     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X           X        X                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X           X        X     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X        X  X        X     X                             X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X           X                                                   |             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                      X   |             
      Fibroadenoma                         |                X  X                                               X      |             
      Fibroadenoma, Multiple               | X                                                     X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +  +      |             
      Rhabdomyosarcoma                     |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Glioma Benign                        |                                                          X               |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                      X   |             
      Leukemia Mononuclear                 |    X     X           X        X     X                             X     X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X           X        X     X                                   X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                               X                                          |             
      Leukemia Mononuclear                 |    X  X  X        X  X        X     X                             X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X  X     X           X     X              X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +     +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Adenoma                              |       X                                                                  |             
      Leukemia Mononuclear                 |             X  X                 X     X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Ganglioneuroma                       |                                                                          |             
      Leukemia Mononuclear                 |             X                          X                                 |             
      Pheochromocytoma Benign              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                 X                                       |             
      Pars Distalis, Adenoma               | X     X  X        X  X  X           X  X  X  X  X     X        X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      Follicular Cell, Carcinoma           |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Adenoma                              |                   X                                                      |             
      Carcinoma                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Deciduoma Benign                     |                                                                          |             
      Polyp Stromal                        |             X                          X           X                     |             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                 X     X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Renal, Leukemia Mononuclear          |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +     M  +  +  +  M  +  +  +  +     M  +  M     +|             
      Leukemia Mononuclear                 |             X  X                 X     X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     M|             
      Leukemia Mononuclear                 |             X  X                       X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                 X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                 X     X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +     +|             
      Leukemia Mononuclear                 |             X  X     X           X     X              X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                X                 X                                       |             
      Thymoma Malignant                    |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                   X           X              X        X                  |             
      Fibroadenoma, Multiple               |                                           X                             X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Basal Cell Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Glioma Benign                        |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Leukemia Mononuclear                 |             X  X                 X     X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |             X  X                 X     X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X  X     X           X     X              X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Ganglioneuroma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Benign              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  44                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Pars Distalis, Adenoma               |    X     X  X  X                                                         |         33 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  47        |
      Adenoma                              |             X                                                            |          8 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  50        |
      Deciduoma Benign                     |             X                                                            |          1 |
      Polyp Stromal                        | X           X                                                            |          6 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  43        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +                                                         |  46        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 | X     X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +                                                         |  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  45                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  50        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |             X                                                            |          8 |
      Fibroadenoma, Multiple               |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Glioma Benign                        |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
      Carcinoma                            |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |         10 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  46                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         17 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                  X                                       |             
      Leukemia Mononuclear                 |          X  X        X     X  X  X     X     X     X        X        X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +  +  +     +                     |             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
      Pharyngeal, Squamous Cell Papilloma  |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X           X     X                                 |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |             X        X     X  X  X           X     X                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X        X  X           X     X                     |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X        X     X              X        X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  48                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                        X           X        X        X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X     X     X     X     X                     |             
      Pars Distalis, Adenoma               | X  X  X  X  X           X  X  X  X  X     X  X  X  X     X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                                                   |             
      C-Cell, Carcinoma                    |                                                                X         |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                         X                                                |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
      Carcinoma                            |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                         X                                                |             
      Bilateral, Interstitial Cell, Adenoma|                      X  X                       X  X              X      |             
      Interstitial Cell, Adenoma           | X                          X     X     X  X                          X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X     X     X     X     X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                 +     +     +  +  +                 +     +     +   |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                            X                                         X   |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                            X           X                                 |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |                      X     X     X     X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  M  M        +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X     X     X     X                           |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  M|             
      Leukemia Mononuclear                 |             X        X     X     X     X     X     X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X     X     X     X     X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +        +  +  +  +  +  +  +  +  +  +  +     M  +  M  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X     X     X     X                           |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X        X     X  X  X     X     X     X        X        X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +        +  +  +  +  M  M  +  +  +  +  +     +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                 X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +        M  M  M  +  +  +  +  +  +  M  +     M  +  +  M  +  +|             
      Fibroadenoma                         |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                    X                     |             
      Keratoacanthoma, Multiple            |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                    X                     |             
      Squamous Cell Papilloma              |                                                    X                     |             
      Subcutaneous Tissue, Fibroma         |             X                                                            |             
      Subcutaneous Tissue, Lipoma          | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Chondrosarcoma                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Glioma Malignant                     |                                                                          |             
      Leukemia Mononuclear                 |             X                    X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |             X        X     X  X  X     X     X     X                 X   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Squamous Cell Carcinoma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X     X           X     X                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X        X     X     X     X     X     X                 X   |             
      Lipoma                               |                            X                                             |             
      Renal Tubule, Adenoma                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X        X     X  X  X     X     X     X        X        X   |             
      Mesothelioma Malignant               |                         X              X                                 |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hepatocellular Adenoma               |             X                                                            |             
      Leukemia Mononuclear                 |    X  X  X  X        X  X  X  X  X  X     X     X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                    +     +        +                        |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Adenoma                              |                         X                                                |             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +           +                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |    X  X  X                 X  X     X           X                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X                    X  X     X           X                        |             
      Pheochromocytoma Malignant           |                                     X                                    |             
      Pheochromocytoma Benign              |          X                       X  X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |    X              X     X              X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Adenoma                              |                               X                 X                 X      |             
      Carcinoma                            |                                  X        X                    X         |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X                    X        X                                    |             
      Pars Distalis, Adenoma               | X  X        X        X  X  X  X  X     X  X  X  X        X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +     +|             
      Adenoma                              |    X                                                                     |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|       X           X                 X                                    |             
      Interstitial Cell, Adenoma           | X  X        X        X  X     X  X                                X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X  X  X        X     X  X     X           X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +              +           +        +                        |             
      Deep Cervical, Leukemia Mononuclear  |                            X                                             |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                            X                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  53                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |    X  X     X                                   X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +     M|             
      Leukemia Mononuclear                 |    X  X              X     X        X     X                              |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X  X                 X  X           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X  X  X        X     X  X  X  X     X     X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X  X           X     X  X     X     X                              |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Fibroma                              |             X                                                            |             
      Leukemia Mononuclear                 |    X  X  X  X        X  X  X  X  X  X     X     X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X                       X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M     +  +  +  M  M  +  +  +  +  M  +     M  M  +  M  M     +|             
      Fibroadenoma                         |                                     X                                    |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Keratoacanthoma                      |       X                                                                  |             
      Keratoacanthoma, Multiple            |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                                             |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Chondrosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Glioma Malignant                     |                                                       X                  |             
      Leukemia Mononuclear                 |       X                    X                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  54                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Leukemia Mononuclear                 |    X  X  X  X        X     X  X  X  X     X     X                        |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                           X                              |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                    X  X  X        X                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X  X  X           X  X  X  X  X     X     X                        |             
      Lipoma                               |                                                                          |             
      Renal Tubule, Adenoma                |                                        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X  X  X  X        X  X  X  X  X  X     X     X                        |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X                                                               |          4 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |       X  X     X                                                         |         26 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +     +                                                               |  12        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X        X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |          7 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  56                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X  X     X                                                         |         17 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         15 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X                                                                        |          9 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          4 |
      Carcinoma                            |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         13 |
      Pars Distalis, Adenoma               | X  X     X     X                                                         |         41 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +                                                         |  49        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  49        |
      Adenoma                              |    X                                                                     |          3 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X     X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X                                                                        |          9 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  57                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Adenoma           |    X  X        X                                                         |         18 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         19 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                                                               |  18        |
      Deep Cervical, Leukemia Mononuclear  |          X                                                               |          2 |
      Iliac, Leukemia Mononuclear          |          X                                                               |          3 |
      Lumbar, Leukemia Mononuclear         |          X                                                               |          1 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          4 |
      Renal, Leukemia Mononuclear          |          X                                                               |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +                                                         |  43        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         14 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         16 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         21 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         17 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibroma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X                                                         |         27 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  44        |
      Leukemia Mononuclear                 |       X  X     X                                                         |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  M                                                         |  33        |
      Fibroadenoma                         |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Keratoacanthoma                      |                                                                          |          2 |
      Keratoacanthoma, Multiple            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  58                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Chondrosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Glioma Malignant                     |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          5 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X                                                         |         23 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X                                                               |         12 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         23 |
      Lipoma                               |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  59                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X  X     X                                                         |         27 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  60                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X        X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X     X  X  X  X     X  X     X     X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +           +                                               +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
      Pharyngeal, Squamous Cell Papilloma  |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X  X           X  X        X     X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X              X        X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                    X              X            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +                                         +                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X  X           X  X     X                 X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X  X  X     X  X  X  X     X  X              X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X  X     X  X  X  X     X  X              X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                X        X                                                |             
      Bilateral, Pheochromocytoma Benign   | X     X                                         X     X        X  X     X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                       X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  61                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X  X           X        X  X     X        X   |             
      Pars Distalis, Adenoma               | X     X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                         X  X                          X              X  X|             
      C-Cell, Carcinoma                    |             X                                                            |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Tunica Vaginalis, Mesothelioma Benign|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 +     +                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X        X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X     X           X           X        X                          X|             
      Interstitial Cell, Adenoma           |          X                    X           X     X  X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X  X  X  X        X  X  X     X        X        X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +              +        +  +                 +            |             
      Pancreatic, Leukemia Mononuclear     |                               X        X                    X            |             
      Renal, Leukemia Mononuclear          |                               X           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     M  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                   X  X  X  X  X           X  X     X        X        X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X  X           X  X     X  X     X        X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  62                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                   X  X  X  X  X           X  X     X        X        X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X  X  X  X        X  X  X     X        X        X  X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X     X  X  X  X     X  X     X     X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X                    X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M  +  +  +  +  M  +  M  +  +  +  M  +  M  M  +  M  +  M  +  M  M  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                   X      |             
      Keratoacanthoma                      |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                   X      |             
      Subcutaneous Tissue, Fibroma         |                X        X                                                |             
      Subcutaneous Tissue, Fibrosarcoma    |                   X  X                                                   |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                               X              X                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X     X                        |             
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |             
      Leukemia Mononuclear                 |                   X  X  X  X  X     X  X  X  X     X  X     X        X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X              X  X        X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  63                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X  X  X  X        X  X  X     X  X     X        X   |             
      Renal Tubule, Adenoma                |                                                 X                        |             
      Renal Tubule, Adenoma, Multiple      |                                                                   X      |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X     X  X  X  X     X  X     X     X  X  X|             
      Mesothelioma Benign                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  64                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X     X  X                       X  X           X  X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X                                   X           X  X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                 X           X  X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                 X              X         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                      X                       X  X           X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X     X                                         X  X  X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X                                               X            |             
      Pheochromocytoma Malignant           |                   X                                                      |             
      Pheochromocytoma Benign              |                      X        X           X     X                        |             
      Bilateral, Pheochromocytoma Benign   |                                              X                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  65                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +     M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X                       X  X           X            |             
      Pars Distalis, Adenoma               |    X     X  X     X  X  X     X  X  X  X  X  X  X  X  X     X     X  X   |             
      Pars Distalis, Carcinoma             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                        X                                 |             
      C-Cell, Carcinoma                    |                   X           X                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |       +                                                                  |             
      Tunica Vaginalis, Mesothelioma Benign|       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X                          X           X            |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Bilateral, Interstitial Cell, Adenoma|                      X  X                 X     X  X                     |             
      Interstitial Cell, Adenoma           |                               X  X                                X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X     X  X                       X  X           X  X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                            +           +            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                 X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    M  +  +  +     +  +  M     +  +  +  M  +  +  +  +  +  +  +  +  +  M   |             
      Leukemia Mononuclear                 |             X     X  X                       X  X           X  X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +     +  +  M     +  +  +  +  M  +  +  +  +  +  +  +  +  M   |             
      Leukemia Mononuclear                 |             X     X  X                          X           X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  66                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |             X     X  X                       X  X           X  X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +  +  +     +  +  +     +  M  +  +  +  +  +  +  +  M  +  +  +  +   |             
      Leukemia Mononuclear                 |             X        X                       X  X           X  X  X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X     X  X  X                    X  X           X  X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  M     +  +  +  +  +  +  M  +  M  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X        X                                      X  X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  +  M     M  +  M     +  +  +  +  M  M  +  +  M  M  +  +  +  +   |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                X         |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |       X                                                                  |             
      Leukemia Mononuclear                 |                                                             X  X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |             X     X  X                       X  X           X  X  X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                      X                       X                 X         |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  67                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X     X  X                       X  X           X  X     X   |             
      Renal Tubule, Adenoma                |                                                                      X   |             
      Renal Tubule, Adenoma, Multiple      |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X     X                             X           X  X         |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |             X     X  X  X                    X  X           X  X  X  X   |             
      Mesothelioma Benign                  |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  68                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Hepatocellular Adenoma               |       X                                                                  |          1 |
      Leukemia Mononuclear                 | X  X  X     X                                                            |         30 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   6        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |         11 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          7 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          6 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |         13 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         18 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         13 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  69                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |    X     X                                                               |          8 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  49        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         15 |
      Pars Distalis, Adenoma               |    X        X                                                            |         43 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      C-Cell, Adenoma                      |    X     X                                                               |          8 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Adenoma             |    X                                                                     |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
      Tunica Vaginalis, Mesothelioma Benign|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  50        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  50        |
      Bilateral, Interstitial Cell, Adenoma|       X  X                                                               |         14 |
      Interstitial Cell, Adenoma           |                                                                          |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  70                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         24 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  10        |
      Pancreatic, Leukemia Mononuclear     | X     X                                                                  |          5 |
      Renal, Leukemia Mononuclear          | X     X                                                                  |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M                                                            |  38        |
      Leukemia Mononuclear                 |       X                                                                  |         20 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  46        |
      Leukemia Mononuclear                 | X     X                                                                  |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  49        |
      Leukemia Mononuclear                 | X     X                                                                  |         22 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  47        |
      Leukemia Mononuclear                 | X     X                                                                  |         21 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X  X  X     X                                                            |         31 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M                                                            |  43        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M                                                            |  29        |
      Fibroadenoma                         |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          2 |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Squamous Cell Carcinoma              |             X                                                            |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |       X                                                                  |          4 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  71                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         25 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         23 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
      Renal Tubule, Adenoma, Multiple      |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          7 |
      Transitional Epithelium, Carcinoma   |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X  X  X     X                                                            |         31 |
      Mesothelioma Benign                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  72                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +  A  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  A  +     +  +  +  A  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  A  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leiomyoma                            |                                                    X                     |             
      Leukemia Mononuclear                 |                      X                             X                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X           X     X              X  X  X  X  X  X  X        X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                          +     +        +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Fat, Lipoma                          |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X                          X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                             X            |             
      Leukemia Mononuclear                 |       X  X           X                    X  X  X     X     X        X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  73                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X  X           X                    X  X  X     X     X        X   |             
      Pheochromocytoma Malignant           |                               X                                          |             
      Pheochromocytoma Benign              |             X              X              X        X        X           X|             
      Bilateral, Pheochromocytoma Benign   |                                              X        X              X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |             X                             X                 X            |             
      Carcinoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  M  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  I     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X                                X  X  X                        |             
      Pars Distalis, Adenoma               | X        X  X        X  X  X  X  X  X     X  X  X  X  X  X  X  X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |             X                                                            |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                            X                                             |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|       X                       X           X     X  X  X     X            |             
      Interstitial Cell, Adenoma           | X        X  X           X           X                    X     X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X           X                    X  X  X  X  X  X  X        X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +     +  +        +           +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |       X  X                                                               |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Leukemia Mononuclear          |                      X                       X                           |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  74                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +  +  +  +     +  +  M  +  +  +     +  +  +  +  +  M  +  +     M  M|             
      Leukemia Mononuclear                 |       X  X           X                    X  X  X     X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     M  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X                                X  X  X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X           X                    X  X  X  X  X  X           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +     +  +  +  +     +  +  +  M  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X                                X  X  X     X     X        X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X           X     X              X  X  X  X  X  X  X        X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +  +  M  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                   X  X                           |             
      Thymoma Malignant                    |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     +  M  +  M     M  M  M  M  M  +     +  M  +  +  M  M  M  +     +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Keratoacanthoma                      |                                                    X                     |             
      Subcutaneous Tissue, Fibroma         |                               X                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                              X  X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X           X                    X  X  X  X  X  X  X        X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                      X  X           X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  75                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                             +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
      Carcinoma                            |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X  X           X     X              X  X  X  X  X                  |             
      Renal Tubule, Adenoma                |                                                                      X   |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X           X     X              X  X  X  X  X  X  X        X   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  76                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
      Leukemia Mononuclear                 |                               X                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                   X      |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia Mononuclear                 | X     X           X  X  X  X  X  X     X  X  X  X     X  X  X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +                                         +              +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Fat, Lipoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia Mononuclear                 | X                 X           X        X              X     X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                         X        X   |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                         X        X   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia Mononuclear                 | X     X           X                    X                    X        X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X     X           X        X  X        X  X  X  X     X     X        X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  77                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X     X           X        X  X        X        X     X              X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X     X     X           X              X           X                    X|             
      Bilateral, Pheochromocytoma Benign   |                            X     X              X                 X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X        X  X           X                 X        X   |             
      Pars Distalis, Adenoma               | X  X  X     X  X  X     X  X     X  X     X  X  X  X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                           X                              |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               | X                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                    X   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               | X                                                                        |             
      Bilateral, Interstitial Cell, Adenoma| X                          X  X     X  X     X              X            |             
      Interstitial Cell, Adenoma           |    X        X  X                          X     X                 X     X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X     X  X  X     X  X     X     X     X        X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +     +  +     +     +  +  +  +        +  +     +      |             
      Leukemia Mononuclear                 |                                                             X            |             
      Iliac, Leukemia Mononuclear          |                   X                       X                 X            |             
      Pancreatic, Leukemia Mononuclear     | X     X                                X     X  X                        |             
      Renal, Histiocytic Sarcoma           |                                                          X               |             
      Renal, Leukemia Mononuclear          | X     X           X        X     X              X           X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  78                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X        X  X     X  X     X           X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +     +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X              X           X                          X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X     X  X  X     X  X  X        X     X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 | X     X           X  X     X  X  X     X  X  X  X           X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X  X  X  X  X     X  X  X  X     X  X  X     X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X                                X                    X            |             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  M  +  +  +  M  M  M  M  +  +  +  +  +  M  M  +  M  M|             
      Carcinoma                            |                            X                                             |             
      Fibroadenoma                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                X                                                         |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +        +                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                           X                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                           X                              |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia Mononuclear                 | X     X           X  X     X  X  X     X  X  X  X     X  X  X     X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X                       X        X              X     X        X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  79                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X     X  X  X     X  X     X     X     X     X  X   |             
      Renal Tubule, Adenoma                |                            X                                             |             
      Transitional Epithelium, Carcinoma   |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                           X        X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia Mononuclear                 | X     X           X  X  X  X  X  X     X  X  X  X     X  X  X     X  X   |             
      Mesothelioma Malignant               | X                                                                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  80                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  49        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  48        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  49        |
      Leiomyoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          5 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         31 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                                                               |  12        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Fat, Lipoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |          8 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X                                                                        |          5 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  81                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         23 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         20 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |    X  X  X                                                               |         16 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          8 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
      Adenoma                              |       X                                                                  |          5 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  49        |
      Leukemia Mononuclear                 | X     X                                                                  |         15 |
      Pars Distalis, Adenoma               | X     X  X  X                                                            |         42 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                                                     |          2 |
      C-Cell, Carcinoma                    |       X                                                                  |          2 |
      Follicular Cell, Adenoma             | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  50        |
      Adenoma                              | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  50        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X        X                                                               |         16 |
      Interstitial Cell, Adenoma           |    X                                                                     |         15 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  82                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         26 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          | X                                                                        |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          7 |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
      Renal, Leukemia Mononuclear          | X                                                                        |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +                                                            |  44        |
      Leukemia Mononuclear                 | X     X                                                                  |         21 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  46        |
      Leukemia Mononuclear                 | X     X                                                                  |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         25 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  48        |
      Leukemia Mononuclear                 | X     X                                                                  |         23 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         31 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +                                                            |  45        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M                                                            |  28        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Keratoacanthoma                      |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  83                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         29 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         13 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         25 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |          5 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         31 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  84                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                       X                  |             
      Leukemia Mononuclear                 |          X     X     X  X        X  X  X           X  X  X              X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +  +  +              +  +                    +|             
      Mesothelioma Malignant               |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                             X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X           X  X           X  X                 X|             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X              X  X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  85                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                         X                                                |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                               X                                          |             
      Bilateral, Pheochromocytoma Benign   |                X     X              X        X  X                 X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X     X  X              X                        |             
      Adenoma, Multiple                    |                                                                          |             
      Carcinoma                            |       X     X                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X           X                 X                 X|             
      Pars Distalis, Adenoma               | X     X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                         X|             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                    +                     |             
      Tunica Vaginalis, Mesothelioma       |                                                                          |             
          Malignant                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Benign                  |                         X                                                |             
      Mesothelioma Malignant               |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                         X|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Benign                  |                         X                                                |             
      Mesothelioma Malignant               |                                                    X                    X|             
      Bilateral, Interstitial Cell, Adenoma|          X     X  X  X        X     X        X                           |             
      Interstitial Cell, Adenoma           |                         X  X           X           X  X                 X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  86                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X           X  X        X  X  X           X  X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
      Pancreatic, Leukemia Mononuclear     |                         X                                                |             
      Renal, Leukemia Mononuclear          |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M     +  M  M  +  M  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +|             
      Leukemia Mononuclear                 |                      X  X        X  X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |          X           X  X           X                 X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X        X  X  X              X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |          X           X  X        X  X  X              X                 X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X     X  X        X  X  X           X  X  X              X|             
      Mesothelioma Malignant               |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  M  +  +  +  +  +  M  M  M  +  M  +  +  +  +  M  +  +  +  M  M  +|             
      Fibroadenoma                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                         X                    X                           |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                X                                                         |             
      Subcutaneous Tissue, Fibroma         |                                              X                           |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
      Mesothelioma Malignant               |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                 X                                                |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  87                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                              X                           |             
      Leukemia Mononuclear                 |          X           X  X        X  X  X           X  X  X              X|             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                         X                                                |             
      Serosa, Mesothelioma Benign          |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X                             X  X                 X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X        X  X  X           X  X  X              X|             
      Mesothelioma Malignant               |                                                                         X|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                    X                    X|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                               X                                          |             
      Leukemia Mononuclear                 |          X     X     X  X        X  X  X           X  X  X              X|             
      Mesothelioma Benign                  |                         X                                      X         |             
      Mesothelioma Malignant               |                                                    X                    X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  88                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                                                                X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                                        X                       X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 | X     X     X  X           X        X  X  X  X  X  X           X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |       X                    X           X  X                              |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                            X           X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                                        X                       X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Odontoma                             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X                                X                             X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X        X                    X  X     X  X              X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |       X                                X        X              X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  89                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Complex             |             X                                                            |             
      Pheochromocytoma Benign              |                            X  X     X     X                              |             
      Bilateral, Pheochromocytoma Benign   |                      X                             X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Adenoma                              |                                        X                                 |             
      Adenoma, Multiple                    |       X                                                                  |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +     +  +     +  +  M  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +     +  +  I  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X                             X  X     X  X              X     X   |             
      Pars Distalis, Adenoma               | X  X  X     X        X  X     X     X  X  X  X  X  X  X  X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |       X                                                                  |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Tunica Vaginalis, Mesothelioma       |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                     X                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +     +  +  +  +     +  +  M  +  +  +  +  +     +  +  +   |             
      Adenoma                              |                            X                                      X      |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Adenoma                              |                                           X                              |             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X           X     X                 X  X  X  X  X     X     X  X      |             
      Interstitial Cell, Adenoma           | X                             X     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  90                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X     X        X           X        X  X  X  X  X  X           X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +        +  +              +     +                    +   |             
      Pancreatic, Leukemia Mononuclear     |       X        X           X                    X                    X   |             
      Renal, Leukemia Mononuclear          |       X                    X              X                          X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  M  +  +     +  +  +   |             
      Leukemia Mononuclear                 |       X        X           X        X  X  X  X  X              X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     M  +     +  +  +  M     +  +  M  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X        X           X        X  X     X  X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X        X           X        X  X  X     X              X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  M     +  +  +   |             
      Leukemia Mononuclear                 |       X        X           X        X  X  X  X  X              X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X     X  X           X        X  X  X  X  X  X           X     X   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M     M  +     +  M  +  +     +  +  +  +  +  M  +  +     +  +  +   |             
      Leukemia Mononuclear                 |                            X           X     X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +     +  M     +  +  +  M     +  M  +  +  M  M  +  +     +  M  M   |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Keratoacanthoma                      |                            X           X  X                          X   |             
      Squamous Cell Papilloma              |                               X                                          |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X                                                                  |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X                                X        X              X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  91                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 | X     X        X           X        X  X  X  X  X  X           X     X   |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                                                                          |             
      Serosa, Mesothelioma Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X                             X  X  X     X              X         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
      Carcinoma                            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Leukemia Mononuclear                 | X     X        X           X        X  X  X  X  X  X           X     X   |             
      Mesothelioma Malignant               |                                                                          |             
      Renal Tubule, Adenoma                |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X     X  X           X        X  X  X  X  X  X           X     X   |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  92                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  48        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 |    X        X  X                                                         |         27 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Odontoma                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  93                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |             X  X                                                         |         18 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |             X                                                            |          9 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |    X  X                                                                  |          7 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          5 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |    X                                                                     |         15 |
      Pars Distalis, Adenoma               | X  X     X     X                                                         |         40 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
      Tunica Vaginalis, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  49        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  94                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|    X  X     X  X                                                         |         22 |
      Interstitial Cell, Adenoma           |          X                                                               |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X        X  X                                                         |         24 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +                                                            |  10        |
      Pancreatic, Leukemia Mononuclear     |             X                                                            |          7 |
      Renal, Leukemia Mononuclear          |             X                                                            |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M                                                         |  38        |
      Leukemia Mononuclear                 |             X                                                            |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +                                                         |  42        |
      Leukemia Mononuclear                 |             X                                                            |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |             X  X                                                         |         20 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |             X  X                                                         |         19 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X        X  X                                                         |         27 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  41        |
      Leukemia Mononuclear                 |             X                                                            |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M  M                                                         |  30        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Keratoacanthoma                      |    X                                                                     |          7 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |    X                                                                     |          3 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  95                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |    X        X  X                                                         |         25 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Medulla      |                                                                          |          1 |
      Serosa, Mesothelioma Benign          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         13 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X        X  X                                                         |         25 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X        X  X                                                         |         27 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  96                                                               
NTP Experiment-Test: 88034-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:21:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Benign                  |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  97                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------