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TDMS Study 88034-06 Pathology Tables

NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  03/09/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|             
                             DAY ON TEST   | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|             
                                           | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                            2                                      4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Epithelium, Hyperplasia              |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Basophilic Focus                     |                                     X                                    |             
      Clear Cell Focus                     |                                                          X               |             
      Eosinophilic Focus                   |                                     X              X                     |             
      Hematopoietic Cell Proliferation     |       2     2                                      2                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |          2                                         1              2      |             
      Pigmentation                         |                         2                                                |             
      Vacuolization Cytoplasmic, Focal     |       2                                                                  |             
      Bile Duct, Cyst                      |                               3                                          |             
      Bile Duct, Hyperplasia               |                                                                   1      |             
      Centrilobular, Degeneration          |       2                                                                  |             
      Centrilobular, Necrosis              |    1                                                                     |             
      Hepatocyte, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +                    +                             +      |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |    3           4                    3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4                                                  1  4     4   |             
      Inflammation                         |          2                                                               |             
      Duct, Cyst                           |                                                                3     3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1        2                                          |             
      Necrosis                             |                                                                          |             
      Epithelium, Hyperplasia              |                      2        4                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|             
                             DAY ON TEST   | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|             
                                           | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  1  1     1     1  1     1  1  1     1     1     1        1  2  1|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Hyperplasia                          |                            2  2                                          |             
      Hypertrophy                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    1           4                                      1                  |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1           4        4  2        2  4     1  1     4  1        1  4   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Atrophy                              | 2  2  3                 4  2  3     2  4     3  3  4  2  3     4  4  3   |             
      Cyst                                 | 2        4     2  1  3     1  2                    2  2  2  3            |             
      Inflammation, Chronic                |                                                                          |             
      Germinal Epithelium, Hyperplasia     |                            2                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                  4                                      3|             
      Hydrometra                           |                                                       4                  |             
      Thrombosis                           |       4                                         3                        |             
      Endometrium, Hyperplasia             |                                                                          |             
      Myometrium, Hyperplasia              |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|             
                             DAY ON TEST   | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|             
                                           | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                            2                                             |             
      Hyperplasia                          |          3  2           2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +                 +                 +        +           +     +|             
      Hyperplasia                          |                                                       2                  |             
      Iliac, Angiectasis                   | 4                                                                 3      |             
      Iliac, Hyperplasia                   |                                                                          |             
      Lumbar, Congestion                   |                            3                                             |             
      Renal, Congestion                    |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  M|             
      Hyperplasia                          |                                                       2                  |             
      Infiltration Cellular, Plasma Cell   |                                           2                              |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                    2  2              3   |             
      Infiltration Cellular, Histiocyte    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     2     3     3     2        2           2     2           2  2     3|             
      Hyperplasia, Lymphoid                |                            2        4                 2  2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  M  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                3  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            1           2              2     3     1  1   |             
      Fracture                             |                                                                          |             
      Cranium, Fracture                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Meninges, Infiltration Cellular      |                            2                       2                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|             
                             DAY ON TEST   | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|             
                                           | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
      Degeneration                         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  1        1                                   1     1  3           1|             
      Inflammation, Chronic Active         |                                  1                 1           1  1      |             
      Inflammation, Suppurative            |    1  1                                                     1            |             
      Epiglottis, Metaplasia, Squamous     |                                           2                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
      Inflammation, Chronic, Focal         |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         2  3                    2  2                 2   |             
      Perivascular, Infiltration Cellular  |       2                    3           2                 2           2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lateral Wall, Fibrosis               |                                           1                              |             
      Lateral Wall, Hyperplasia            |                                                 1                        |             
      Lateral Wall, Inflammation,          |                                                                          |             
          Suppurative                      |                                           1  1  1                        |             
      Lateral Wall, Metaplasia, Squamous   |                                           1                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                 1                        |             
      Olfactory Epithelium, Atrophy        |    1           2        1           1           2  1                     |             
      Turbinate, Hyperplasia               |                                                                          |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +           +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                   2      |             
      Hydronephrosis                       |                                                                         2|             
      Metaplasia, Osseous                  |                         1     1     1                                    |             
      Nephropathy                          |       1        1     1  1     1        1           1              1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5|            |
                             DAY ON TEST   | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4|            |
                                           | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  A  +|  43        |
      Inflammation, Suppurative            |                                                             2            |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|  45        |
      Necrosis                             |                                                                   1      |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                         X                                                |      3     |
      Hematopoietic Cell Proliferation     |          1                                                               |      4  1.8|
      Inflammation, Chronic                |                                                             2     2      |      2  2.0|
      Necrosis                             |          1     2        1                                         2      |      7  1.6|
      Pigmentation                         |                                                                   2      |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Hepatocyte, Atrophy                  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +        +  +        +  +  +           +     +            |  13        |
      Artery, Inflammation                 |                                                       2                  |      1  2.0|
      Fat, Inflammation, Chronic           |                                                             2            |      1  2.0|
      Fat, Necrosis                        |       2                 3  2        2  2  2                              |      9  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                          2               |      5  3.0|
      Inflammation                         |                                                             2            |      2  2.0|
      Duct, Cyst                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|  48        |
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Necrosis                             |                                                             1            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5|            |
                             DAY ON TEST   | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4|            |
                                           | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                                             2            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|  48        |
      Necrosis                             |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1  2  1  1  1  1  1  1     1  1  1  1  1        1  1  1  1  1      |     37  1.1|
      Necrosis                             |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                         1|      3  1.7|
      Hypertrophy                          |          1              1  2     1     1                                 |      6  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |       1                 1                                2               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  +  +  M  +  +  +  +  M  +  +  +  M  M  +  M  +  +  +  M  M|  36        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |       1        2     1     4           1  2     3           1            |     11  1.9|
      Pars Intermedia, Hyperplasia         |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |       2     2  2     1  1  1                    1     1  3  2            |     22  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +|  45        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |             2                                   2                        |      3  2.0|
      Atrophy                              |    3              2     2        3  4  2  3  3  4     3     3     3      |     28  3.0|
      Cyst                                 |       2  3           1     3     3     1  3  4        3  3        2     2|     23  2.3|
      Inflammation, Chronic                |                                                          4               |      1  4.0|
      Germinal Epithelium, Hyperplasia     |                         2                                                |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5|            |
                             DAY ON TEST   | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4|            |
                                           | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                     1                    2  4     4      |      4  2.8|
      Cyst                                 |                         2  2  3                             4            |      6  3.0|
      Hydrometra                           | 3                    3                                                   |      3  3.3|
      Thrombosis                           |                                                                          |      2  3.5|
      Endometrium, Hyperplasia             |                                                                   3      |      1  3.0|
      Myometrium, Hyperplasia              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                             2            |      2  2.0|
      Hyperplasia                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +     +        +                 +  +           +         |  15        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Iliac, Angiectasis                   |                                                                          |      2  3.5|
      Iliac, Hyperplasia                   |                                                                2         |      1  2.0|
      Lumbar, Congestion                   |                                                                          |      1  3.0|
      Renal, Congestion                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  M  M  +  +  +  +|  36        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  M  M  A  +  +  +  +  +  M  +|  38        |
      Hyperplasia                          | 2                                                              2         |      2  2.0|
      Necrosis                             |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|  45        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  43        |
      Hyperplasia                          |          2                                               3               |      5  2.4|
      Infiltration Cellular, Histiocyte    |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |          2                                2  2  2                        |     15  2.2|
      Hyperplasia, Lymphoid                | 2                          2                                             |      6  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +|  35        |
      Atrophy                              |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5|            |
                             DAY ON TEST   | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4|            |
                                           | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       1                 2  1           3  2              2  2  1  1      |     15  1.7|
      Fracture                             |          X                                                               |      1     |
      Cranium, Fracture                    |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                   2                                                      |      1  2.0|
      Meninges, Infiltration Cellular      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                 1                    1  1  2              1   |     13  1.2|
      Inflammation, Chronic Active         |                                                                          |      4  1.0|
      Inflammation, Suppurative            |                                                       1              1   |      5  1.0|
      Epiglottis, Metaplasia, Squamous     |                                                                         1|      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                         2                                2               |      3  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      5  2.2|
      Perivascular, Infiltration Cellular  |                                                          1               |      6  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lateral Wall, Fibrosis               |                                                                          |      1  1.0|
      Lateral Wall, Hyperplasia            |                                                                          |      1  1.0|
      Lateral Wall, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                          |      3  1.0|
      Lateral Wall, Metaplasia, Squamous   |                   1                                                      |      2  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5|            |
                             DAY ON TEST   | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4|            |
                                           | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |          2                                                               |      2  1.5|
      Olfactory Epithelium, Atrophy        |          2        2                                   1                  |      9  1.4|
      Turbinate, Hyperplasia               |                   2                                                      |      1  2.0|
      Turbinate, Inflammation, Suppurative |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                +                 +         |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |       1                                                                  |      4  1.0|
      Nephropathy                          | 1     1  1           1  1  1        2  1  1  1        1  1        1     2|     24  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|             
                                           | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  M  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                                              X           X               |             
      Inflammation, Chronic                |                      2                                         2         |             
      Necrosis                             |                            4  3                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Necrosis              |          1                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +                                      +               |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 1                       2|             
      Necrosis                             |                                                                          |             
      Epithelium, Hyperplasia              |    1                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1  1  1  2  1  2  1  1  2  1  1  1  2     1     1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                      1                           |             
      Hypertrophy                          |                            1        1                                    |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  M  M  M  +  M  +  M  M  +  +  +  +  +  +  M  I  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|             
                                           | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                1           4  3  1  2                    4  4  2         |             
      Pars Intermedia, Hyperplasia         |                                     2     2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1  4  2  3     2     3  3  2  2  1  3  1        2           3  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Atrophy                              |    2  2  2     4  3        2  3  2  2     3  2  2  3  3  2     3  2  2   |             
      Cyst                                 |       4           2  1  4  3  1  2              2  1        1  1         |             
      Necrosis                             |                                                                          |             
      Germinal Epithelium, Hyperplasia     |                                  2  2                          2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2              2                                    |             
      Cyst                                 |                                           3                              |             
      Hemorrhage                           |    4                                                                     |             
      Hydrometra                           | 2                       3                                4           2   |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                         +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  M  M  +  +  +  M  +  M  M  +  +  +  +  +  M  M  M  M|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                  2                             2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  +  +  +  +  +  +  M  +  M|             
      Hyperplasia                          | 2        2        2                                2                 2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2     2        2                             4  2     2        3  2   |             
      Hyperplasia, Histiocytic             |       2                                                                  |             
      Hyperplasia, Lymphoid                |                      2  2              2     4     2           2  3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|             
                                           | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  M  +  +|             
      Atrophy                              |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       1  2     2        3  3  2  1        3           2        1     1  1|             
      Cranium, Myelofibrosis               |                         X                                                |             
      Femur, Myelofibrosis                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                             1              1  1     2           2   |             
      Inflammation, Suppurative            |                                                          1               |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                                        2         |             
      Alveolar Epithelium, Hyperplasia     |          2                                                               |             
      Alveolar Epithelium, Metaplasia      | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1     1  1  1  2  1  1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1  1  1  1  1  1  1  1  1  1  1  2  1  1  1     1     1  1  1  2  1  1|             
      Mediastinum, Angiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
      Lateral Wall, Degeneration, Hyaline  | 3  2  2  2  2  2  1  2  2  3  2  2  2  2  2  2  3  2  1  2  2  2  2  2  2|             
      Lateral Wall, Fibrosis               | 2        1  2              1  1           1  1  1  1  1  1     1  1      |             
      Lateral Wall, Hyperplasia            |    2  2  2  2  2  1  2  2  3  2  2  2  2  2  2     2  1  2  2  1  2  2  1|             
      Lateral Wall, Inflammation,          |                                                                          |             
          Suppurative                      | 1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Lateral Wall, Metaplasia, Squamous   |                      1                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             1                                                            |             
      Olfactory Epithelium, Atrophy        |    2  3  1  3        1  2  2  2  2  2  2           3           2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|             
                                           | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +     +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                 4                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                2     1  1  1  1  1  1  1     1     1        1  1     1   |             
      Pelvis, Dilatation                   |                                                 3                        |             
      Renal Tubule, Hyperplasia            |    4        1                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8|            |
                             DAY ON TEST   | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5|            |
                                           | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  A  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  A  +  +  +  +  M  +  +  +  +  +  M  +  A  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                      2                                                   |      1  2.0|
      Eosinophilic Focus                   |             X                 X  X     X                                 |      6     |
      Inflammation, Chronic                |                                        2           1                     |      4  1.8|
      Necrosis                             |                                                       2                  |      3  3.0|
      Pigmentation                         |             2     2                                                      |      2  2.0|
      Bile Duct, Cyst                      |                                              3  2                        |      2  2.5|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                       +                                       |   5        |
      Fat, Necrosis                        |          3                       2                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Atrophy                              |                                           4                              |      1  4.0|
      Duct, Cyst                           |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      2                                                   |      3  1.7|
      Necrosis                             |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia              |                                        1                                 |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Inflammation, Acute                  |                      1                                                   |      1  1.0|
      Necrosis                             |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1  2        1     1  1  1     1  1  1  1  1     1  1  1        2|     38  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Hypertrophy                          |    1     1                    1                                          |      5  1.0|
      Capsule, Hyperplasia                 |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8|            |
                             DAY ON TEST   | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5|            |
                                           | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia                          |                            3              1                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  M  +  +  M  M|  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |                               4              3  2  2           1  2      |     14  2.5|
      Pars Intermedia, Hyperplasia         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |    1  1  1  2           2  2  1              3                          1|     24  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +  +|  48        |
      Angiectasis                          |                                                          2               |      2  2.0|
      Atrophy                              |    2  2     3  2  3     2  2  1  2     3  2  2  4  3  1                  |     33  2.4|
      Cyst                                 |    1  2        2                       3     1     2           2         |     18  1.9|
      Necrosis                             |                                                                         4|      1  4.0|
      Germinal Epithelium, Hyperplasia     |                               1                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            2                                             |      3  2.0|
      Cyst                                 |                   2                                                      |      2  2.5|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                    4                     |      5  3.0|
      Inflammation, Suppurative            |                                                    2                     |      1  2.0|
      Endometrium, Hyperplasia             |          2                             1                                 |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +           +              +   |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  I  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +|  32        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  I  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +|  40        |
      Hematopoietic Cell Proliferation     |                                                       2                  |      1  2.0|
      Hyperplasia                          |                            2                                      2      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8|            |
                             DAY ON TEST   | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5|            |
                                           | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                    2                     |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                       2                  |      1  2.0|
      Hyperplasia                          |                                                                   4      |      1  4.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +  +  M  M  +  +  M  M  +  M  +  +  +  +  +  +  A  +  +  +  +|  36        |
      Hyperplasia                          |          2                 2                 2                    3      |      9  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2     2  2  2     2     2  2                 2     3  3                  |     19  2.3|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                               2        2                                 |      9  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  +  +  +  +  +  M  M  +  +  +  +  +  M  M  +  M  +  A  +  +  +  M|  35        |
      Atrophy                              |                      3                                   4               |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1                             2           3  2                 1  1      |     18  1.8|
      Cranium, Myelofibrosis               |                                                                          |      1     |
      Femur, Myelofibrosis                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Meninges, Infiltration Cellular      |          1                                         3                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia                          |                            1     1  1                                1  2|     11  1.3|
      Inflammation, Suppurative            |                                     1                    1              1|      4  1.0|
      Epiglottis, Metaplasia, Squamous     |                                                                   1     1|      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia      | 1  2  1  1  1     1  1  1  1  1  1     1  1  1  1  1     1     1  1     1|     43  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8|            |
                             DAY ON TEST   | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5|            |
                                           | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1  2  3           2  2  1  1     1  1  1  1  1     1     1        4|     39  1.3|
      Mediastinum, Angiectasis             |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Artery, Inflammation                 |                                                    2                     |      1  2.0|
      Lateral Wall, Degeneration, Hyaline  | 1  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2     2  2  2  3|     49  2.0|
      Lateral Wall, Fibrosis               |    1     1        1           1     1     1  1  1  1                    1|     23  1.1|
      Lateral Wall, Hyperplasia            | 1  2  2  2  2           1  2  2  2  2  1  2  2  2  2     2     1  2     3|     42  1.9|
      Lateral Wall, Inflammation,          |                                                                          |            |
          Suppurative                      | 1  1  1  1  1           1  1  1  2  1     1  1  1  1     1     1  1  1  1|     44  1.0|
      Lateral Wall, Metaplasia, Squamous   |             1                                                           1|      3  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |          2  2     1           2     2        2  2  2     1              1|     23  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                        +                                 |   1        |
      Inflammation, Granulomatous          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +     +     +                                                         |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Infarct                              |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                      1   |      1  1.0|
      Nephropathy                          |    1  1  1  1           1  1  1  1     1  1  1     1     1              1|     27  1.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|             
                             DAY ON TEST   | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|             
                                           | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +|             
      Necrosis                             |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X                    X                                          |             
      Eosinophilic Focus                   |                                                    X                     |             
      Hematopoietic Cell Proliferation     |    1              2                          1                           |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                   1                                2                     |             
      Pigmentation                         |                   1                                                      |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +  +  +              +                       +  +|             
      Fat, Necrosis                        |                            2                 4                       3   |             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                +                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4                                                                  |             
      Basophilic Focus                     |          X        X        X                                             |             
      Inflammation                         |                                              2                           |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     2                                    |             
      Necrosis                             |                                     3                                    |             
      Epithelium, Hyperplasia              |                                     4        1                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1  2  1  2  1     1  1  1  1     1  1  1  1        1  1|             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|             
                             DAY ON TEST   | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|             
                                           | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
      Hypertrophy                          |             1              1                                         1   |             
      Capsule, Hyperplasia                 |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  M  +  M  +  M  +  +  M  M  +  +  +  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          1           4                 1                 1  1        2   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Intermedia, Hypertrophy         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1  2        1  1     1     3     3  1     4           1     1     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  M  M|             
      Inflammation, Chronic Active         |                                                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Atrophy                              | 2  3        2  3     3              2     2  3  2     3  2  3           2|             
      Cyst                                 | 2              2  4                 1     1  2                 2  2     2|             
      Inflammation, Chronic                |                                           2                              |             
      Interstitial Cell, Hyperplasia       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                1         |             
      Cyst                                 |    3                                   2                                 |             
      Decidual Reaction                    |                                                                          |             
      Hydrometra                           |             3                                                            |             
      Inflammation, Chronic                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                    4                    3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +     +        +                                       |             
      Lumbar, Hyperplasia                  |                                                                          |             
      Renal, Hyperplasia                   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  M  M  +  M  +  +  +  M  M  +  +  M  M  +  +  +  M  M  M  M  +|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  +  +  +  M  +  M  +  +  +|             
      Hyperplasia                          |                2           3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|             
                             DAY ON TEST   | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|             
                                           | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|             
      Angiectasis                          | 3                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  M  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  4  2     2  2  4  2  2              3     2  2  2           2     2   |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  M  +  +  M  +  +  +  +  M  +  M  M  +  +  M  +  M  +  +  +  +|             
      Atrophy                              |                   2                                                      |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vulva, Inflammation, Suppurative     |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chondradysplasia                     |                                        X                                 |             
      Fibrous Osteodystrophy               |    2     1     1     2                          2                 1      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Meninges, Infiltration Cellular      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     1                 1  3  1  2           1     2  1        1        1|             
      Inflammation, Suppurative            |       1                 1  1                                             |             
      Necrosis                             |                                                                          |             
      Epiglottis, Hyperplasia              |                                                                          |             
      Epiglottis, Metaplasia, Squamous     | 1  1     1  1        1     1  2     1     1     1     1              1  1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Chronic                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |             
      Alveolar Epithelium, Metaplasia      | 3  2  1  3  2  2  3  1  1  3  2  2  1  3  2  2  2  2  3  3  3  2  1  2  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1  1  2  2  2  2  1     2  2  1  1  1  3     2  2  3  2  2  1  1  2  2|             
      Mediastinum, Necrosis                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|             
                             DAY ON TEST   | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|             
                                           | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Perivascular, Infiltration Cellular  |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lateral Wall, Degeneration, Hyaline  | 3  2  2  2  3  2  3  2  2  2  2  2  2  4  2  3  3  2  2  2  2  2  2  2  2|             
      Lateral Wall, Fibrosis               | 1  2  1  1  1  1  1  1  1  1  2  1  1  2  1     2  1  1  2  2  1  1  2  1|             
      Lateral Wall, Hyperplasia            | 2  2  2  2  3  2  2  2  2  2  2  2  2     2  1  3  2  2  2  2  2  2  2  2|             
      Lateral Wall, Inflammation,          |                                                                          |             
          Suppurative                      | 1  2  1  1  1  2  1  1  1  1  2  1  1  2  1  1  2  1  1  2  2  1  1  2  1|             
      Lateral Wall, Metaplasia, Squamous   |    1  1  2        1  1  1  1  2        3  1     1     2                 3|             
      Lateral Wall, Necrosis               |                   1                                                      |             
      Olfactory Epithelium, Atrophy        | 3  3  1  3     2  1  2  1  4     3  1     2  2  2     2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                        1                                 |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                  3                                       |             
      Hydronephrosis                       |       2                                                                  |             
      Karyomegaly                          |                                                                          |             
      Metaplasia, Osseous                  |       2                             1                                    |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1     1  1  1     1  1  1  1     1     1  1  2     1        1     1  2|             
      Cortex, Inflammation, Suppurative    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9|            |
                             DAY ON TEST   | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1|            |
                                           | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Necrosis                             |                            2                                             |      1  2.0|
      Peyer's Patch, Hyperplasia           |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Basophilic Focus                     |       X                                                                  |      3     |
      Eosinophilic Focus                   |                                           X        X                     |      3     |
      Hematopoietic Cell Proliferation     |                                                                   2      |      4  1.5|
      Inflammation, Chronic                |                         2                                                |      1  2.0|
      Necrosis                             |                                                                2         |      3  1.7|
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                 +  +                     |  10        |
      Fat, Necrosis                        |                               2                                          |      4  2.8|
      Lymphatic, Angiectasis               |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |    2                 3                                                   |      3  3.0|
      Basophilic Focus                     |             X                 X                                          |      5     |
      Inflammation                         |                                                                          |      1  2.0|
      Duct, Cyst                           |                      3                             2                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                              2                 1         |      3  1.7|
      Necrosis                             |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |    4                       2        1        1                           |      6  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                               2                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9|            |
                             DAY ON TEST   | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1|            |
                                           | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 1     1     1     1     1     2  2     1  1        1  1  1  1  3  1     2|     36  1.2|
      Inflammation, Suppurative            |    2                                                                     |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                                                           1   |      3  1.3|
      Hypertrophy                          |                                        1  1           1                  |      6  1.0|
      Capsule, Hyperplasia                 |                                           2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                    2                          1              1|      4  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  +  +  M  M  M  +  M  +  +  +  +  +  M  +  I  +  +  M  M  +|  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           | 2  2  1  4           2        1                       2  3  2        1   |     16  1.9|
      Pars Intermedia, Hyperplasia         | 2                                                                        |      1  2.0|
      Pars Intermedia, Hypertrophy         |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 2  1  1  2  1     4     3  4     1     2  2  1  1  1  3  3  2           2|     30  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  42        |
      Inflammation, Chronic Active         |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              | 3  2  2              2  3  4  2  2     2  3  2        3  2  3     3  2  2|     30  2.5|
      Cyst                                 | 3           2     3     2                          3     2           3   |     16  2.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                                          3               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1                                                                        |      2  1.0|
      Cyst                                 |                                  2        4  3  3        2  2           4|      9  2.8|
      Decidual Reaction                    |                                        2                                 |      1  2.0|
      Hydrometra                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9|            |
                             DAY ON TEST   | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1|            |
                                           | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         3                                                |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +           +           +                 +              +      |   9        |
      Lumbar, Hyperplasia                  |                                                                   2      |      1  2.0|
      Renal, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +|  33        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  41        |
      Hyperplasia                          |                                                                         2|      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  M  M  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2                 3  2              2                       3     2  2|     21  2.3|
      Hyperplasia, Lymphoid                | 2           2                             2                              |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  +  M  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  33        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                        2                    2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            4                    2                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vulva, Inflammation, Suppurative     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Chondradysplasia                     |                                                                          |      1     |
      Fibrous Osteodystrophy               | 1        2                    2  1        1           2  2              1|     14  1.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                         1|      1  1.0|
      Meninges, Infiltration Cellular      |                            1                             2               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9|            |
                             DAY ON TEST   | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1|            |
                                           | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1  1  1  2              1           1     1  1           1  1     2  1  1|     24  1.3|
      Inflammation, Suppurative            |       1  2              1     3           1  2                       1   |     10  1.4|
      Necrosis                             |                                           1                          1   |      2  1.0|
      Epiglottis, Hyperplasia              |                         1                    1              1  1         |      4  1.0|
      Epiglottis, Metaplasia, Squamous     | 1  1                                            1  1     1              1|     19  1.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Chronic                  |                                                                2     4   |      2  3.0|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    4                                                        4            |      3  3.0|
      Alveolar Epithelium, Metaplasia      | 3  1  2  2  1  3  2  2  2  2  3  2  3  3  3  3  1  2  3  2  2  1  2  1  2|     50  2.1|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  1  1  3  1     2  1  4  2  2  2     2  2  2  1  2  2  2  1     1  4  2|     45  1.8|
      Mediastinum, Necrosis                |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lateral Wall, Degeneration, Hyaline  | 2  3  2  2  2  4  2  2  2  2  3  3  4  2  2  3  3  3  3  2  2  4  2  2  2|     50  2.4|
      Lateral Wall, Fibrosis               | 1  1  1     1  2  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  2  1  1  1|     48  1.2|
      Lateral Wall, Hyperplasia            | 2  2  2  2  2     2  2  2  2  2  2  3  2  2  2  2  2  2  2  2     2  2  2|     47  2.0|
      Lateral Wall, Inflammation,          |                                                                          |            |
          Suppurative                      | 1  1  1  1  1  2  1  1  1  1  1  1  2  1  1  2  1  1  2  1  1  2  1  1  1|     50  1.3|
      Lateral Wall, Metaplasia, Squamous   | 1  1        1  2  1  1  1  1  1              1  1  1        2  3        1|     28  1.4|
      Lateral Wall, Necrosis               |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        | 3  2  1  3  2     3  1  2  3     2     2  2  2  2  2  1  3  3     3     3|     40  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mineralization                       |                               2                                          |      1  2.0|
      Necrosis                             |                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +     +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |          3                                                               |      2  3.0|
      Hydronephrosis                       |                                  2                                       |      2  2.0|
      Karyomegaly                          |       1                 2                                                |      2  1.5|
      Metaplasia, Osseous                  |                                              1     1           1         |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9|            |
                             DAY ON TEST   | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1|            |
                                           | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                               3                                          |      1  3.0|
      Nephropathy                          | 1     1     1     1        1  2        1  1  1        1  1           1  2|     30  1.1|
      Cortex, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|             
                             DAY ON TEST   | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|             
                                           | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  A  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Necrosis                             |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                 X                                       |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                                              2                           |             
      Eosinophilic Focus                   |                            X     X  X                          X         |             
      Hematopoietic Cell Proliferation     |             3                                                            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |                                                 1                    3   |             
      Necrosis                             |             1                 1                                      3   |             
      Bile Duct, Cyst                      |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                                    |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2                 3                  |             
      Basophilic Focus                     |                   X                                                      |             
      Vacuolization Cytoplasmic            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                               2                                          |             
      Necrosis                             |                                              1                           |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  1        1  1  2        1  2  1  1  2  2     1  1  1  1  1  1  3|             
      Inflammation, Suppurative            |                               2                                          |             
      Necrosis                             |                                                                          |             
      Atrium, Thrombosis                   |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  I  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                1           2                           |             
      Hypertrophy                          | 1        1              2  1              1  1           3  1        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|             
                             DAY ON TEST   | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|             
                                           | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Hyperplasia                 |                                              2  2              2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2  4|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1                                         1  1  1     1     1     1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                         +               |             
      Inflammation, Suppurative            |                2                                         3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                3        4                             3|             
      Inflammation, Chronic Active         |                      3  4                 4     4           3           4|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +|             
      Hyperplasia                          | 1                                                                        |             
      Inflammation, Suppurative            |                3                       2                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1        1     3        3           1           3                       1|             
      Interstitial Cell, Hyperplasia       |                      2              2                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                  2         |             
      Necrosis                             |                            4                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                 +                                 |             
      Iliac, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                        4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  M  +  +  +  M  M  +  +  +  +  M  M  +  A  +  M  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  +  +  +  +  +  I  +  +  +  M  +  +  +  M  +  +  +  +  M  +  M|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|             
                             DAY ON TEST   | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|             
                                           | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                         2                                            1  3|             
      Congestion                           |                                     4                                    |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  A  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Hematopoietic Cell Proliferation     |    2        3           3  2  2     2  2                             2  2|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Pigmentation, Melanin                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  M  +  M  +  +  M  +  +  M  M  +  A  +  M  +  +  +  M  M|             
      Atrophy                              |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                4                       4                       4  4      |             
      Subcutaneous Tissue, Hemorrhage      |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +        +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                              X                           |             
      Hemorrhage                           |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1              1                                      1     1            |             
      Inflammation, Acute                  |                   1                                                      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                         1                                                |             
      Inflammation, Suppurative            |                                                                         2|             
      Epiglottis, Hyperplasia              |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                                           1                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis                          |                               1                                          |             
      Hemorrhage                           |                                                          1               |             
      Alveolar Epithelium, Hyperplasia     |          4                                      4     1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|             
                             DAY ON TEST   | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|             
                                           | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lateral Wall, Degeneration, Hyaline  |                                                                          |             
      Lateral Wall, Hyperplasia            |                                                                          |             
      Lateral Wall, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Lateral Wall, Metaplasia, Squamous   |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2              2                                       |             
      Olfactory Epithelium, Atrophy        |                                              2              1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Inflammation                         |                   4                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +        +              +     +                    +            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             2            |             
      Infarct                              |                               4                                          |             
      Nephropathy                          | 2  2  1  1  1  1  1              1        2  1  1     1  1  1     1  2  3|             
      Papilla, Inflammation, Suppurative   |                2              2        3                                 |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                3                       3                                 |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                4                       4                                 |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9|            |
                             DAY ON TEST   | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0|            |
                                           | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                            X                                             |      1     |
      Degeneration, Fatty                  |                                  2                                       |      2  2.0|
      Eosinophilic Focus                   |       X     X  X  X     X     X                                          |     10     |
      Hematopoietic Cell Proliferation     |                                                                2         |      2  2.5|
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      3  1.7|
      Bile Duct, Cyst                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   3        |
      Fat, Necrosis                        |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                   2      |      3  2.3|
      Basophilic Focus                     |                                                                          |      1     |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia              |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis                             |                                        1                                 |      2  1.0|
      Epithelium, Hyperplasia              |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1     1  1  1  1  1  2  1  1     2  2  1  1  1  1  2  1  1     2  1|     40  1.3|
      Inflammation, Suppurative            |                                                                   1      |      2  1.5|
      Necrosis                             |                                                                   3      |      1  3.0|
      Atrium, Thrombosis                   |                                           4                              |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9|            |
                             DAY ON TEST   | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0|            |
                                           | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |       2                    2  2                       2  1           2   |      9  1.7|
      Hypertrophy                          |                   1  1  1  2  1  1     1     1  1        3           1   |     20  1.3|
      Capsule, Hyperplasia                 |             2  2  2                          2                       3   |      9  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             4                 1              2           3               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |                               1                                          |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |       2     3     1           4        1  1  2  1     1              1   |     18  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granuloma Sperm                      |                                                          3               |      1  3.0|
      Inflammation                         |                      2              2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +                                +               |   4        |
      Inflammation, Suppurative            |                                                          2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                3  4           2  3  2        4           3               |     11  3.0|
      Inflammation, Chronic Active         |       3     2     3              1  3              3  2              3  2|     15  2.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                         1                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            4  3                       4                 2|     11  2.4|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9|            |
                             DAY ON TEST   | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0|            |
                                           | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                             3            |      3  2.3|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Iliac, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  M  M  +  +  +  +  M  M  +  M  M  +  +  M  M  M  +  +  M  M|  26        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +  +  M  +  M  +  M  +  +|  34        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      3  2.0|
      Congestion                           |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                4         |      2  3.0|
      Hyperplasia                          |       2                       2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  M  +  M|  37        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2                    2                             2        2  2         |     14  2.1|
      Hyperplasia, Lymphoid                |                               4                                          |      2  3.0|
      Pigmentation, Melanin                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  M  +  M  +  M  +  +  +  I  +  M  M  +  +  M  +  +  M|  29        |
      Atrophy                              |                         3           2     3                              |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                         2|      1  2.0|
      Prepuce, Inflammation, Chronic Active| 3                 4     4              3  2     4           4            |     11  3.6|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9|            |
                             DAY ON TEST   | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0|            |
                                           | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      4  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                1         |      1  1.0|
      Inflammation, Chronic Active         |       1     1     1                    1                                1|      6  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Epiglottis, Hyperplasia              |       1                                                                  |      1  1.0|
      Epiglottis, Metaplasia, Squamous     |                                                                      1   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |             3  3        3        1                       4           3  2|     10  2.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   2                          4                       3   |      3  3.0|
      Perivascular, Infiltration Cellular  |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lateral Wall, Degeneration, Hyaline  |                                                       1        2         |      2  1.5|
      Lateral Wall, Hyperplasia            |                                                       1     1            |      2  1.0|
      Lateral Wall, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                             1            |      1  1.0|
      Lateral Wall, Metaplasia, Squamous   |                                                                      1   |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Olfactory Epithelium, Atrophy        |                                  2                                   2   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                +                           |   3        |
      Inflammation                         |                                              3                           |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                +                           |   7        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |       2     2                    2                                       |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9|            |
                             DAY ON TEST   | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0|            |
                                           | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy                          | 1     2     1  1  2  1  2  1  1  1  3  1  2  1  1  1  1  2  1  1  2  1  2|     40  1.4|
      Papilla, Inflammation, Suppurative   |                                                                          |      3  2.3|
      Papilla, Necrosis                    |                         2                                                |      1  2.0|
      Pelvis, Dilatation                   |                                                                          |      2  3.0|
      Renal Tubule, Hyperplasia            |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|             
                             DAY ON TEST   | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|             
                                           | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                                                             1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Degeneration, Fatty                  |                               3                                          |             
      Eosinophilic Focus                   | X                 X                    X  X                 X            |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                  3        1        2                    1|             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Necrosis              |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                          +                          +|             
      Fat, Necrosis                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |                   1                 4                                    |             
      Duct, Cyst                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                           1                              |             
      Epithelium, Hyperplasia              |                                           1                       1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
      Inflammation, Acute                  |                               3                                          |             
      Mineralization                       |                      2                                                   |             
      Necrosis                             |    2                          3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1     1  1        1     1  2  1     1     1  2  1  1  1     2|             
      Mineralization                       |                                                 1                        |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |       2              1     2     2                 2        2     2     1|             
      Hypertrophy                          | 1     2     1           1     1              1     1        2  1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|             
                             DAY ON TEST   | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|             
                                           | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Hyperplasia                 |          2        2  2     2        3                 2     2           2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                                   2      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |       1                    2                                2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Follicular Cell, Hyperplasia         | 1  1        1              3     1     1                 2  4           1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |                                                                          |             
      Granuloma Sperm                      | 4                                                                        |             
      Inflammation, Chronic                |                                              4                           |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                         +                     |             
      Inflammation, Suppurative            |          3                                         2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst                                 | 2                                3  3                       3     3     2|             
      Inflammation, Chronic Active         |                            4  1        4        1              3  3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                   1                                2     3     1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |             3     1                                         4  1         |             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                      3                                         3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
      Iliac, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  M  M  M  +  +  M  +  M  +  +  M  +  +  +  +  M  M  M  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  +  +  M  I  +  M  +  M  +  +  M  +  M  +  M  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|             
                             DAY ON TEST   | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|             
                                           | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  M  +  +  I  +  +  M  +  M  +  +  M  +  +  +  +  A  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hematopoietic Cell Proliferation     |          2        2                       2     2  2  2        2         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  +  +  +  +  +  +  +  M  M  M  +  +  M  M  +  +  M  M  A  +|             
      Atrophy                              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             4            |             
      Epidermis, Hyperplasia               |       1                    2                                             |             
      Prepuce, Inflammation, Chronic Active|       4  4        4  4                 3     4                 4         |             
      Subcutaneous Tissue, Edema           |                                           3                              |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Mast Cell              |                                  2                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                          1        2      |             
      Inflammation, Chronic Active         |             1              1        1                          1         |             
      Inflammation, Suppurative            |                                                          1        1      |             
      Epiglottis, Hyperplasia              |                                                          1               |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2     4  3                          4                                   1|             
      Alveolar Epithelium, Metaplasia      | 1  1     2  1  1  2  2  2  2  2  1  2  1  3  1  2  2  1  1  1  1  2     2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1     4  2     1  1     1  1     2  1     1  2  1  1  1  1  1  1     1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lateral Wall, Degeneration, Hyaline  | 1  1  1  1  1  2  2  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|             
                             DAY ON TEST   | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|             
                                           | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lateral Wall, Fibrosis               |       1  1  1     1        1                       1                     |             
      Lateral Wall, Hyperplasia            | 1     1  1  1     1  2     1  1  1  1     1  1     1  1  1  1  1  1     1|             
      Lateral Wall, Inflammation,          |                                                                          |             
          Suppurative                      | 1     1  1  1     1  1     1  1  1  1  1  1  1     1  1  1  1  1        1|             
      Lateral Wall, Metaplasia, Squamous   |             1                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        |             1                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                    +                                   +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst                                 |                            2                                             |             
      Hydronephrosis                       |                                                    2                     |             
      Mineralization                       |                                        2                       2         |             
      Nephropathy                          | 2  2  1  1  2  1  1  1  1  1  1  1  1     2  1        1     1  1  1     1|             
      Cortex, Inflammation, Suppurative    |                                        2                 3               |             
      Papilla, Inflammation, Suppurative   |                                        2           2     3     1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Calculus Gross Observation           |                                                    X     X     X         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                        4           3     4     4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6|            |
                             DAY ON TEST   | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1|            |
                                           | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |
      Inflammation, Suppurative            |                      1                                                   |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                         X                                                |      1     |
      Degeneration, Fatty                  |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                X  X                    X                 X               |      9     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Necrosis                             |    2                             1                 1                 1   |      8  1.5|
      Bile Duct, Cyst                      |                      3                                                   |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                    4                     |      3  3.0|
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    3                                                                     |      2  2.0|
      Epithelium, Hyperplasia              |                3                                         4               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |             1                                                            |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     1  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1  2  2  1  1|     40  1.2|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6|            |
                             DAY ON TEST   | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1|            |
                                           | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2                                2        2        2     1|     13  1.8|
      Hypertrophy                          |                         2     1           1        1        2     2      |     16  1.3|
      Capsule, Hyperplasia                 |                               2              2                    2  2   |     12  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                       1                  |      2  1.5|
      Thrombosis                           |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  M  M  +  M  +  M  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |                                                       2                  |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |       1           1  1  1              1  1              3  1  1  1  1   |     20  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                          4               |      1  4.0|
      Granuloma Sperm                      |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                               3                 4        3  3     3      |     11  2.9|
      Inflammation, Chronic Active         |                   1           3                 4  2  2  4  1            |     13  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                                                                      2   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                3        2  2              2              1           2   |     10  2.1|
      Mineralization                       |                                           2                              |      1  2.0|
      Interstitial Cell, Hyperplasia       |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6|            |
                             DAY ON TEST   | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1|            |
                                           | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                   3                                   2              2   |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                           +         |   3        |
      Iliac, Pigmentation                  |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  +  M  M  M  +  M  +  M  +  M  +  +  M  +  +  +  M  +  M  +|  27        |
      Hyperplasia                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  M  +  +  +  M  +  M  M  M  +  M  M  +  +  +  +|  31        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Congestion                           |                                                             3     2      |      2  2.5|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Hyperplasia                          |                      2                                   2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +|  39        |
      Hyperplasia                          | 3           2     3  2                             2                     |      5  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |             2  2  2        2     2                    2              2   |     14  2.0|
      Hyperplasia, Lymphoid                |                      2                                   3               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  M  M  M  +  M  M  +  M  +  M  +  M  M  +  +  +  +  M  M  +|  26        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Epidermis, Hyperplasia               |                                                                          |      2  1.5|
      Prepuce, Inflammation, Chronic Active|                   4  4     4                          4              4  4|     13  3.9|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Mast Cell              |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                    2     2               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6|            |
                             DAY ON TEST   | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1|            |
                                           | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2                    1        1              1  1         |      7  1.3|
      Inflammation, Chronic Active         |                            1           2              1                  |      7  1.1|
      Inflammation, Suppurative            |                                     1                       2  2         |      5  1.4|
      Epiglottis, Hyperplasia              |                                           1                              |      2  1.0|
      Epiglottis, Metaplasia, Squamous     |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic, Focal         |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                      4        4                       4                  |      8  3.3|
      Alveolar Epithelium, Metaplasia      | 1  1  1  2  1  2  1  1  2  2  1  1  1  1  2  3  1  1  1  2  2  1  1  1  2|     48  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 3     1  1  3  4  4  3  1  1  1     3  1  4  3  2  3  1  1  1     4  1   |     40  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Lateral Wall, Degeneration, Hyaline  | 1  1  1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  1  1  1  1     1  1  1|     48  1.1|
      Lateral Wall, Fibrosis               |    1                                                                    1|      8  1.0|
      Lateral Wall, Hyperplasia            |       1  1     1  2  1        2        1  1  1  1     1  1        1  1   |     33  1.1|
      Lateral Wall, Inflammation,          |                                                                          |            |
          Suppurative                      |    1           1  1  1  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1|     38  1.0|
      Lateral Wall, Metaplasia, Squamous   |                               2                                          |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                               2        2                                 |      2  2.0|
      Olfactory Epithelium, Atrophy        |                   3           3           2                              |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                         +|   1        |
      Inflammation                         |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                       +     +                 +        +|   8        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Nephropathy                          | 1     1  2  3  1  1  1  1  1  1  1  2  1  1  1  2  1  1  2  1     1  1  1|     43  1.2|
      Cortex, Inflammation, Suppurative    |                                                                          |      2  2.5|
      Papilla, Inflammation, Suppurative   |                            2                                         2   |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6|            |
                             DAY ON TEST   | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1|            |
                                           | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Gross Observation           |                                                                          |      3     |
      Inflammation, Chronic Active         |                                                                      4   |      1  4.0|
      Inflammation, Suppurative            |                            4                                             |      5  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|             
                             DAY ON TEST   | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|             
                                           | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                  1                                       |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  A  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             
      Basophilic Focus                     |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                                                                      X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Infiltration Cellular, Mast Cell     |                                                                2         |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |       4           1                                                      |             
      Bile Duct, Cyst                      |                                  2  2                                    |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                +                       +        +      |             
      Artery, Inflammation, Chronic Active |                                                                   4      |             
      Fat, Necrosis                        |                                  3                       2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |    1                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             
      Infiltration Cellular, Mast Cell     |                                                                1         |             
      Necrosis                             |       1                                1                                 |             
      Epithelium, Hyperplasia              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                        2                                 |             
      Epithelium, Hyperplasia              |                                              3                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|             
                             DAY ON TEST   | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|             
                                           | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  1  1  1  1     1  1  1  1     1  1     1  1     1  1  1  1  1  1     1|             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
      Atrium, Thrombosis                   |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                  3           2        2|             
      Hypertrophy                          |                                  2  1           1        1               |             
      Capsule, Hyperplasia                 |                                  3                 4                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                    2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  M  +  M  M  +  M  M  +  +  +  +  M  +  I  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                      3                                                   |             
      Pars Intermedia, Hyperplasia         |                                  1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 2  2     3  4  2  1     2     3  2  1     1  1  2  1  2  1     1        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Penis                                   |    +     +        +                                   +  +     +         |             
      Inflammation, Suppurative            |    2     1                                            3  1               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                      3                    2         |             
      Hyperplasia                          |                         4                                                |             
      Inflammation, Chronic Active         |                               3                             4            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2     2                                   2            |             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                                        |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|             
                             DAY ON TEST   | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|             
                                           | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                          4               |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia                          |                   2                                         3            |             
      Infiltration Cellular, Mast Cell     |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                   +           +|             
      Congestion                           |                                                                          |             
      Iliac, Hyperplasia                   |                         2                                   2            |             
      Renal, Hyperplasia                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  +  +  M  +  +  M  +  +  +  +  M  +  M  +  M  +  M  M  +  M  M|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  +  +  M  +  M  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
      Infiltration Cellular, Mast Cell     |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  I  +  +|             
      Angiectasis                          |                                                             2            |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |          2                 2                    2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2     2           1                    2  2     2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  M  M  +  M  +  M  +  M  +  M  M  M  +  M  M  M  +  M  I  +|             
      Atrophy                              |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  I|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Inflammation, Chronic Active|    4     4        4  3  4           4                 4  4  4  3  4  4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1  1  1     1     1              1                 1  1     1  1   |             
      Inflammation, Chronic Active         | 1  1                       1                                            1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|             
                             DAY ON TEST   | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|             
                                           | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |       2                                1                                 |             
      Epiglottis, Hyperplasia              |                                                                   1  1   |             
      Epiglottis, Metaplasia, Squamous     |          1                       1     1     1  1        1     2        1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                    4                     |             
      Alveolar Epithelium, Metaplasia      | 2  3     4  2  2     3  3  2  2  3  2  2  2  3  1  3  2  2  2  2  3  2  3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1     3  1  1     2  2  4  1  2  1     1  1  4  2  2  1     2  1     1|             
      Bronchiole, Metaplasia               |          1                                                               |             
      Bronchiole, Necrosis                 |                                                                   1      |             
      Perivascular, Infiltration Cellular  |                               2                 3                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lateral Wall, Degeneration, Hyaline  | 3  3  2  1  2  2  2  3  2  2  3  3  2  2  3  2  2  3  2  3  2  2  3  3  3|             
      Lateral Wall, Fibrosis               | 1  1     1  2  1  1  2        1  2  1  1  1  1  1  1  1  2  2  1  2  2  1|             
      Lateral Wall, Hyperplasia            | 1  2     2  2  1  1  3  2     2  2  1  2  2  2  2  2  2  2  1  1  1  2  2|             
      Lateral Wall, Inflammation,          |                                                                          |             
          Suppurative                      | 1  1     2  2  1  1  1  1  1     1  1  1  1  1  2  1  1  2  1  1  2  1  2|             
      Lateral Wall, Metaplasia, Squamous   | 1  1     2     2        1        1  1  1        1        1               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        |       2  3  2  1           2     1  2     2     3  2  1  1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                               +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                               1                     |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1  1        1  1     1     2     1  1     2  1  1  2  1  1     1        1|             
      Cortex, Inflammation, Suppurative    |                   2     2                                   2            |             
      Papilla, Inflammation, Suppurative   |                   1     2                                2  1        1   |             
      Pelvis, Dilatation                   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             4            |             
      Inflammation, Suppurative            |                   2     4                                4           1   |             
      Transitional Epithelium, Hyperplasia |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7|            |
                             DAY ON TEST   | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1|            |
                                           | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  A  +  A|  40        |
      Inflammation, Suppurative            |                                           1                              |      2  1.0|
      Mineralization                       |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  A|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  A|  41        |
      Peyer's Patch, Hyperplasia           |                                                 2  2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                X                                   X                     |      2     |
      Degeneration, Fatty                  |    2                          2                                          |      2  2.0|
      Eosinophilic Focus                   |                                  X                                   X   |      3     |
      Hematopoietic Cell Proliferation     |                                                                   1      |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                            1                                             |      1  1.0|
      Necrosis                             |                                        1                                 |      3  2.0|
      Bile Duct, Cyst                      |                                                                          |      2  2.0|
      Centrilobular, Necrosis              |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Atrophy                              | 1                                                                        |      1  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
      Necrosis                             |       1                                                                  |      3  1.0|
      Epithelium, Hyperplasia              |       2     1                                                            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Necrosis                             |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                      +   |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7|            |
                             DAY ON TEST   | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1|            |
                                           | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +                                                                  |   1        |
      Mineralization                       |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     1  1  2  1     1  1  1     1  1     1  1  1  1  1  1  1  1     1  1|     40  1.1|
      Necrosis                             |       1                                                                  |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                              4                           |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Hyperplasia                          |                                        2  1  2                       2   |      8  2.1|
      Hypertrophy                          |             1  1        1  1     1           2        2     2  1         |     13  1.3|
      Capsule, Hyperplasia                 |                3           2     2  3           2                        |      7  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  M  M  M  +  +  M  M  M  M  M  M  +  +  M  +  M  M  M|  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |                1           1                                             |      3  1.7|
      Pars Intermedia, Hyperplasia         |                                              1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |       1  1  3  2           1     1  1     1  2  1  2  1        2     2   |     32  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                     +                                    |   7        |
      Inflammation, Suppurative            |                                     3                                    |      5  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | 4     2              2                    2     2                        |      8  2.5|
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |       2     3           2  3                 3                 3     2   |      9  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Inflammation, Suppurative            |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7|            |
                             DAY ON TEST   | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1|            |
                                           | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
      Inflammation, Suppurative            |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                3                          1        2           4         |      5  2.4|
      Mineralization                       |                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Hyperplasia, Megakaryocyte           |                                                          2               |      1  2.0|
      Hyperplasia                          |                                           2                              |      3  2.3|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +     +                                +                  |   7        |
      Congestion                           |                                                       2                  |      1  2.0|
      Iliac, Hyperplasia                   |                                                                          |      2  2.0|
      Renal, Hyperplasia                   |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  M|  32        |
      Hyperplasia                          |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  M  M  +  +  I  M  M  +  M  M  M  +  +  +  +  M  +|  32        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  A  +  +|  44        |
      Angiectasis                          |                            2     2           2                           |      4  2.0|
      Hyperplasia                          |                3                                      2                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  43        |
      Hyperplasia                          |          2                                                     2         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     1                                    |      1  1.0|
      Hematopoietic Cell Proliferation     | 2     2              3  2           2              2  2  2        4      |     15  2.1|
      Hyperplasia, Lymphoid                |                2                                                         |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  +  +  I  +  +  +  +  M  M  +  M  +  M  M  +  I  +  +|  25        |
      Atrophy                              | 4     3                                                        3        2|      5  3.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Inflammation, Chronic Active|          4                 4                                      3     4|     16  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7|            |
                             DAY ON TEST   | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1|            |
                                           | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                      2                                                   |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1           2              2  1                 1               |     15  1.1|
      Inflammation, Chronic Active         |                2                 1                                   1   |      7  1.1|
      Inflammation, Suppurative            |                      1              2                                    |      4  1.5|
      Epiglottis, Hyperplasia              |                                                                          |      2  1.0|
      Epiglottis, Metaplasia, Squamous     |                                                 1     1                  |     10  1.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  4.0|
      Alveolar Epithelium, Metaplasia      | 2  2  2  2  2  2  2  2  2  3  2  3  1  2  2  2  2  1  3  2  1  2     2  2|     47  2.2|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 3        1  2  2  1  1  1  2     1  4  1  1  2  2  3  1  1  1  3     2  1|     41  1.7|
      Bronchiole, Metaplasia               |                                                                          |      1  1.0|
      Bronchiole, Necrosis                 |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular  |                                                    2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lateral Wall, Degeneration, Hyaline  | 2  3  3  3  3  2     2  2  2  3  2  2  3  2  2  2  3  2  4  3  3  4  2  2|     49  2.5|
      Lateral Wall, Fibrosis               | 1  2  1  2  1  1        1  1  2  1  1  1  1  2  1  1     2  1  1  1  1   |     43  1.3|
      Lateral Wall, Hyperplasia            | 2  1  2     2  2     2  1  2  1  2  2  2  2  2  2  2  2  1  2  3     2  2|     45  1.8|
      Lateral Wall, Inflammation,          |                                                                          |            |
          Suppurative                      | 1  2  1  2  2        1  1  1  2  1  1  1  1  2  1  1  1  1  1  1  2  2  1|     46  1.3|
      Lateral Wall, Metaplasia, Squamous   | 1     1     1  1     1           1  2        2        1           1      |     20  1.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       2                             2                                    |      2  2.0|
      Olfactory Epithelium, Atrophy        |                1                    1     1  1  2     2                  |     18  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Metaplasia, Squamous                 |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 88034-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7|            |
                             DAY ON TEST   | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1|            |
                                           | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   1        |
      Inflammation                         |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                +        +                  |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                2                                                         |      3  1.7|
      Infarct                              |                                                                   4      |      1  4.0|
      Nephropathy                          | 2     1  1  2  2     1  1  1  1  1  1  1  1  1  1  2  1  3  1  3     1   |     37  1.3|
      Cortex, Inflammation, Suppurative    |                                                                          |      3  2.0|
      Papilla, Inflammation, Suppurative   |                                                                   4      |      6  1.8|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                   3      |      2  3.5|
      Inflammation, Suppurative            |                                                                         4|      5  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
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