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TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:41:08

                                                       51 WEEK SSAC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/23/97

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     11/01/95 - 11/01/95

       Treatment Groups:       Include 002    0 PPM
                               Include 010    3750 PPM
                               Include 001    0 PPM
                               Include 009    3750 PPM































Note:  Animals arranged according to days on test

                                                              Page   1



NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 3| 3|                                                           |     A      |
    0 PPM                                  | 8| 8| 9| 1| 2|                                                           |     L      |
                                           | 4| 8| 9| 7| 2|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 3| 3|                                                           |     A      |
    0 PPM                                  | 8| 8| 9| 1| 2|                                                           |     L      |
                                           | 4| 8| 9| 7| 2|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 5| 5| 5| 5|                                                           |     A      |
    3750 PPM                               | 8| 0| 1| 3| 3|                                                           |     L      |
                                           | 2| 0| 3| 4| 8|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 5| 5| 5| 5|                                                           |     A      |
    3750 PPM                               | 8| 0| 1| 3| 3|                                                           |     L      |
                                           | 2| 0| 3| 4| 8|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 3| 3| 3| 3| 3|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |     A      |
    0 PPM                                  | 3| 3| 3| 4| 5|                                                           |     L      |
                                           | 3| 6| 7| 0| 8|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
      Interstitial Cell, Adenoma, Multiple | X                                                                        |          1 |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 3| 3| 3| 3| 3|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |     A      |
    0 PPM                                  | 3| 3| 3| 4| 5|                                                           |     L      |
                                           | 3| 6| 7| 0| 8|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 3| 3| 3| 3| 3|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    3750 PPM                               | 2| 4| 4| 5| 6|                                                           |     L      |
                                           | 8| 6| 7| 2| 9|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
      Interstitial Cell, Adenoma, Multiple | X                                                                        |          1 |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 88036-03          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:41:08  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 3| 3| 3| 3| 3|                                                           |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    3750 PPM                               | 2| 4| 4| 5| 6|                                                           |     L      |
                                           | 8| 6| 7| 2| 9|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------